Ensembl_Gene_ID,evidence_pass,evidence_status,failure_reasons,positive_evidence_inside,positive_evidence_reproductive,selectivity_gate_applied,selectivity_exclusions,manageable_worst_selectivity_margin,protected_worst_selectivity_margin,vital_worst_selectivity_margin,rna_routine_missing,ihc_routine_missing,ihc_coverage,vital_rna_max_ntpm,protected_rna_max_ntpm,manageable_rna_max_ntpm,rna_exclusions,ihc_exclusions,ihc_forbidden_contexts_observed,absence_evidence,tissue_review_status,tissue_review_flags,tissue_review_contexts,historical_nomination_review_eligible,historical_nomination_review_reason,nomination_review_eligible,nomination_review_reason,screen_review_superseded_holdback,screen_review_warning,screen_review_reference,Symbol,scenario,family_eligible,screen_review_applied,retained,previous_retained,source_dois,source_publications,admission_only_retained,selectivity_revised_retained,grid_revised_retained,current_adaptive_retained,current_fixed_retained,change,gain_stage
ENSG00000000460,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 52.9101% (minimum 75%, Missing); lymph node: 61.7284% (minimum 70%, Missing); parathyroid gland: 43.4783% (minimum 70%, Missing); retina: 65.3595% (minimum 75%, Missing); thymus: 46.9484% (minimum 65%, Missing)",-0.180516,-0.265217,-0.220899,0,0,routine_complete,8.9,13,11.3,"parathyroid gland: 13 nTPM (protected, limit 3); thymus: 11.3 nTPM (manageable, limit 5); bone marrow: 8.9 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 3); retina: 5.3 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 3); cerebellum: 3 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FIRRM,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000001631,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.8235% (minimum 65%, Supported); amygdala: 68.9655% (minimum 75%, Missing); basal ganglia: 65.9341% (minimum 75%, Missing); cerebellum: 53.5714% (minimum 65%, Supported); cerebral cortex: 63.4921% (minimum 65%, Supported); choroid plexus: 67.0391% (minimum 75%, Missing); colon: 58.5366% (minimum 70%, Missing); duodenum: 66.2983% (minimum 75%, Missing); heart muscle: 50.0000% (minimum 65%, Supported); hippocampal formation: 68.5714% (minimum 75%, Missing); hypothalamus: 65.9341% (minimum 75%, Missing); kidney: 56.8720% (minimum 65%, Supported); liver: 59.7015% (minimum 65%, Supported); midbrain: 67.7966% (minimum 75%, Missing); pancreas: 60.3015% (minimum 65%, Supported); parathyroid gland: 43.1655% (minimum 60%, Supported); pituitary gland: 56.6038% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 74.5342% (minimum 75%, Missing); salivary gland: 59.7015% (minimum 60%, Supported); skeletal muscle: 49.1803% (minimum 65%, Supported); small intestine: 62.8272% (minimum 75%, Missing); smooth muscle: 61.2245% (minimum 65%, Supported); spinal cord: 65.5738% (minimum 75%, Missing); thymus: 52.8634% (minimum 65%, Missing); thyroid gland: 48.7805% (minimum 55%, Supported); tongue: 48.0000% (minimum 70%, Missing); urinary bladder: 58.8235% (minimum 60%, Supported)",-0.121366,-0.22,-0.183962,0,6,partial,12.4,15.8,12.6,"parathyroid gland: 15.8 nTPM (protected, limit 6); tongue: 13 nTPM (protected, limit 3); skeletal muscle: 12.4 nTPM (vital, limit 3); heart muscle: 12 nTPM (vital, limit 3); thymus: 10.7 nTPM (manageable, limit 5); cerebellum: 10.4 nTPM (vital, limit 3); pituitary gland: 9.2 nTPM (vital, limit 1); kidney: 9.1 nTPM (vital, limit 3); colon: 8.5 nTPM (protected, limit 3); adrenal gland: 8.4 nTPM (vital, limit 3); urinary bladder: 8.4 nTPM (protected, limit 6); liver: 8.1 nTPM (vital, limit 3); salivary gland: 8.1 nTPM (protected, limit 6); stomach: 7.9 nTPM (protected, limit 6); pancreas: 7.9 nTPM (vital, limit 3); esophagus: 7.7 nTPM (protected, limit 6); smooth muscle: 7.6 nTPM (vital, limit 3); small intestine: 7.1 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 3); lung: 6.3 nTPM (vital, limit 3); spinal cord: 6.3 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); choroid plexus: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1)",colon / enterocytes: Low (Supported); colon / goblet cells: Low (Supported); duodenum / enterocytes: Low (Supported); rectum / endothelial cells: Low (Supported),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KRIT1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000004809,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 50.7317% (minimum 75%, Missing)",0.295455,0.14898,-0.242683,0,1,partial,20.2,3.7,1.2,"bone marrow: 20.2 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 3); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC22A16,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000004838,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342888,0.285877,0.00284602,0,80,unavailable,82.5,3.6,1.8,"choroid plexus: 82.5 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); lung: 10.8 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); retina: 3.1 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZMYND10,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000005175,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.7736% (minimum 65%, Missing); adrenal gland: 62.1324% (minimum 75%, Missing); amygdala: 72.2222% (minimum 75%, Missing); basal ganglia: 71.9149% (minimum 75%, Missing); bone marrow: 57.2881% (minimum 75%, Missing); cerebellum: 65.5039% (minimum 75%, Missing); cerebral cortex: 58.0756% (minimum 75%, Missing); choroid plexus: 66.0156% (minimum 75%, Missing); colon: 58.2759% (minimum 70%, Missing); duodenum: 55.7756% (minimum 75%, Missing); esophagus: 56.3333% (minimum 70%, Missing); heart muscle: 52.0000% (minimum 75%, Missing); hippocampal formation: 73.1602% (minimum 75%, Missing); hypothalamus: 66.5354% (minimum 75%, Missing); kidney: 57.4830% (minimum 75%, Missing); liver: 52.9781% (minimum 75%, Missing); lung: 63.0597% (minimum 75%, Missing); lymph node: 36.8996% (minimum 70%, Missing); midbrain: 71.9149% (minimum 75%, Missing); pancreas: 67.0635% (minimum 75%, Missing); parathyroid gland: 50.2976% (minimum 70%, Missing); pituitary gland: 67.8715% (minimum 75%, Missing); rectum: 57.6792% (minimum 70%, Missing); retina: 61.0108% (minimum 75%, Missing); salivary gland: 64.0152% (minimum 70%, Missing); skeletal muscle: 43.4447% (minimum 75%, Missing); skin: 60.7914% (minimum 65%, Missing); small intestine: 57.8767% (minimum 75%, Missing); smooth muscle: 53.3123% (minimum 75%, Missing); spinal cord: 68.6992% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 61.0108% (minimum 70%, Missing); thymus: 42.4623% (minimum 65%, Missing); thyroid gland: 55.7756% (minimum 65%, Missing); tongue: 42.6768% (minimum 70%, Missing); urinary bladder: 50.9036% (minimum 70%, Missing)",-0.225377,-0.331004,-0.315553,0,3,partial,22,28.9,22.9,"lymph node: 28.9 nTPM (protected, limit 3); thymus: 22.9 nTPM (manageable, limit 5); tongue: 22.7 nTPM (protected, limit 3); skeletal muscle: 22 nTPM (vital, limit 1); spleen: 16.9 nTPM (manageable, limit 5); parathyroid gland: 16.7 nTPM (protected, limit 3); urinary bladder: 16.3 nTPM (protected, limit 3); heart muscle: 15.6 nTPM (vital, limit 1); liver: 15 nTPM (vital, limit 1); smooth muscle: 14.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (manageable, limit 5); duodenum: 13.4 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 3); bone marrow: 12.6 nTPM (vital, limit 1); kidney: 12.5 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 3); small intestine: 12.3 nTPM (vital, limit 1); cerebral cortex: 12.2 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 3); skin: 10.9 nTPM (manageable, limit 5); stomach: 10.8 nTPM (protected, limit 3); retina: 10.8 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); lung: 9.9 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); salivary gland: 9.5 nTPM (protected, limit 3); cerebellum: 8.9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); pancreas: 8.3 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RPAP3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000005189,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.328892,0.246376,0.23787,0,2,partial,11.4,38.6,7.2,"parathyroid gland: 38.6 nTPM (protected, limit 4); bone marrow: 11.4 nTPM (vital, limit 2); thymus: 7.2 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 3); retina: 4.1 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 2); duodenum: 2.9 nTPM (vital, limit 2); smooth muscle: 2.6 nTPM (vital, limit 2); cerebellum: 2.5 nTPM (vital, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 2); basal ganglia: 1.8 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,REXO5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000005889,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 54.3165% (minimum 65%, Missing); adrenal gland: 69.5853% (minimum 75%, Missing); bone marrow: 34.0858% (minimum 75%, Missing); cerebellum: 68.6364% (minimum 75%, Missing); cerebral cortex: 69.2661% (minimum 75%, Missing); colon: 61.3821% (minimum 70%, Missing); duodenum: 69.5853% (minimum 75%, Missing); esophagus: 68.6364% (minimum 70%, Missing); heart muscle: 63.9831% (minimum 75%, Missing); kidney: 66.2281% (minimum 75%, Missing); liver: 60.6426% (minimum 75%, Missing); lung: 64.5299% (minimum 75%, Missing); lymph node: 57.1970% (minimum 70%, Missing); pancreas: 61.1336% (minimum 75%, Missing); parathyroid gland: 50.3333% (minimum 70%, Missing); pituitary gland: 71.9048% (minimum 75%, Missing); retina: 60.4000% (minimum 75%, Missing); salivary gland: 67.7130% (minimum 70%, Missing); skeletal muscle: 50.8418% (minimum 75%, Missing); small intestine: 65.6522% (minimum 75%, Missing); smooth muscle: 51.8900% (minimum 75%, Missing); spinal cord: 73.6585% (minimum 75%, Missing); spleen: 55.7196% (minimum 65%, Missing); stomach: 66.2281% (minimum 70%, Missing); thymus: 47.3354% (minimum 65%, Missing); thyroid gland: 59.2157% (minimum 65%, Missing); tongue: 55.7196% (minimum 70%, Missing); urinary bladder: 63.1799% (minimum 70%, Missing)",-0.176646,-0.196667,-0.409142,0,4,partial,29.2,14.9,16.8,"bone marrow: 29.2 nTPM (vital, limit 1); thymus: 16.8 nTPM (manageable, limit 5); parathyroid gland: 14.9 nTPM (protected, limit 3); skeletal muscle: 14.6 nTPM (vital, limit 1); smooth muscle: 14 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (manageable, limit 5); tongue: 12 nTPM (protected, limit 3); spleen: 12 nTPM (manageable, limit 5); lymph node: 11.3 nTPM (protected, limit 3); thyroid gland: 10.4 nTPM (manageable, limit 5); retina: 9.9 nTPM (vital, limit 1); liver: 9.8 nTPM (vital, limit 1); pancreas: 9.6 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 3); urinary bladder: 8.8 nTPM (protected, limit 3); heart muscle: 8.5 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); skin: 7.8 nTPM (manageable, limit 5); kidney: 7.7 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 3); salivary gland: 7.2 nTPM (protected, limit 3); cerebellum: 6.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 3); cerebral cortex: 6.7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 3); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZFX,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000006047,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.299813,0.246466,0,1,partial,3.9,7,2.9,"hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,YBX2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000006059,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 4.9587% (minimum 65%, Missing)",-0.600413,0.127273,0.25,0,6,partial,0,0.9,46,"skin: 46 nTPM (manageable, limit 5)",,67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,hair / cells in cortex/medulla; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KRT33A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000006459,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.3548% (minimum 65%, Missing); bone marrow: 36.2205% (minimum 75%, Missing); cerebral cortex: 73.0159% (minimum 75%, Missing); colon: 53.1792% (minimum 70%, Missing); duodenum: 53.4884% (minimum 75%, Missing); esophagus: 57.8616% (minimum 70%, Missing); heart muscle: 70.2290% (minimum 75%, Uncertain); kidney: 72.4409% (minimum 75%, Missing); liver: 58.5987% (minimum 75%, Missing); lung: 66.6667% (minimum 75%, Missing); lymph node: 57.5000% (minimum 70%, Missing); pancreas: 67.6471% (minimum 75%, Missing); parathyroid gland: 69.6970% (minimum 70%, Missing); rectum: 50.5495% (minimum 70%, Missing); retina: 61.7450% (minimum 75%, Missing); salivary gland: 65.2482% (minimum 70%, Missing); skeletal muscle: 42.9907% (minimum 75%, Missing); skin: 55.7576% (minimum 65%, Missing); small intestine: 53.1792% (minimum 75%, Missing); smooth muscle: 68.6567% (minimum 75%, Missing); spleen: 63.0137% (minimum 65%, Missing); stomach: 50.2732% (minimum 70%, Missing); thymus: 58.5987% (minimum 65%, Missing); tongue: 42.0091% (minimum 70%, Missing); urinary bladder: 62.5850% (minimum 70%, Missing)",-0.0924242,-0.279909,-0.387795,0,1,partial,16.2,12.7,7.3,"bone marrow: 16.2 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 3); skeletal muscle: 12.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 3); rectum: 9 nTPM (protected, limit 3); small intestine: 8.1 nTPM (vital, limit 1); colon: 8.1 nTPM (protected, limit 3); duodenum: 8 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); lymph node: 6.8 nTPM (protected, limit 3); esophagus: 6.7 nTPM (protected, limit 3); thymus: 6.5 nTPM (manageable, limit 5); liver: 6.5 nTPM (vital, limit 1); adipose tissue: 6.3 nTPM (manageable, limit 5); retina: 5.7 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 3); spleen: 5.4 nTPM (manageable, limit 5); salivary gland: 4.9 nTPM (protected, limit 3); lung: 4.6 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 3); heart muscle: 3.9 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KDM7A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000006634,True,compatible,,True,True,True,,0.310784,0.267105,0.210784,0,80,unavailable,0.6,0.5,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DBF4,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000006659,True,compatible,,True,True,True,,0.336025,0.29374,0.242188,0,80,unavailable,0.5,0.4,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LGALS14,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",True,True,True,True,True,unchanged,
ENSG00000006837,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.278105,0.120809,0.0217391,0,80,unavailable,4.2,3.1,1.1,"retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CDKL3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000007038,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.336811,0.255284,0.221665,0,5,partial,7.7,19.9,1.7,"salivary gland: 19.9 nTPM (protected, limit 12); bone marrow: 7.7 nTPM (vital, limit 6); lung: 2.4 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRSS21,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000007174,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 73.6501% (minimum 75%, Missing); hippocampal formation: 72.3992% (minimum 75%, Missing); hypothalamus: 74.7807% (minimum 75%, Missing)",0.347076,0.297076,-0.0260085,0,4,partial,13,3.5,2,"hippocampal formation: 13 nTPM (vital, limit 1); choroid plexus: 12.2 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); amygdala: 8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAH9,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000007350,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346769,0.295964,0.233267,0,2,partial,3.7,0.5,0.7,"retina: 2.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TKTL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000008256,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.3891% (minimum 65%, Missing); amygdala: 68.2222% (minimum 75%, Missing); basal ganglia: 61.4000% (minimum 75%, Missing); cerebellum: 62.0202% (minimum 75%, Missing); cerebral cortex: 57.8154% (minimum 75%, Missing); colon: 63.5611% (minimum 70%, Missing); duodenum: 65.7388% (minimum 75%, Uncertain); esophagus: 69.3002% (minimum 70%, Uncertain); heart muscle: 52.6587% (minimum 75%, Missing); hippocampal formation: 65.4584% (minimum 75%, Missing); kidney: 68.9888% (minimum 75%, Missing); lung: 61.6466% (minimum 75%, Missing); midbrain: 70.0913% (minimum 75%, Missing); skeletal muscle: 67.7704% (minimum 75%, Missing); skin: 59.4961% (minimum 65%, Missing); small intestine: 65.4584% (minimum 75%, Uncertain); smooth muscle: 72.5768% (minimum 75%, Missing); stomach: 69.4570% (minimum 70%, Missing); thyroid gland: 53.2986% (minimum 65%, Missing); tongue: 61.7706% (minimum 70%, Missing); urinary bladder: 69.6145% (minimum 70%, Uncertain)",-0.126109,-0.0822938,-0.223413,0,5,partial,27.6,19,27.9,"adipose tissue: 27.9 nTPM (manageable, limit 5); heart muscle: 27.6 nTPM (vital, limit 1); thyroid gland: 26.9 nTPM (manageable, limit 5); cerebral cortex: 22.4 nTPM (vital, limit 1); skin: 20.9 nTPM (manageable, limit 5); basal ganglia: 19.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); tongue: 19 nTPM (protected, limit 3); cerebellum: 18.8 nTPM (vital, limit 1); colon: 17.6 nTPM (protected, limit 3); hippocampal formation: 16.2 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); duodenum: 16 nTPM (vital, limit 1); skeletal muscle: 14.6 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); kidney: 13.8 nTPM (vital, limit 1); esophagus: 13.6 nTPM (protected, limit 3); stomach: 13.5 nTPM (protected, limit 3); urinary bladder: 13.4 nTPM (protected, limit 3); midbrain: 13.1 nTPM (vital, limit 1); smooth muscle: 11.6 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 3); parathyroid gland: 11.1 nTPM (protected, limit 3); spleen: 10.7 nTPM (manageable, limit 5); hypothalamus: 10.2 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 7.3 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); thymus: 5.6 nTPM (manageable, limit 5); retina: 5.5 nTPM (vital, limit 1); lymph node: 5.2 nTPM (protected, limit 3); choroid plexus: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CYTH3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000008294,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.2308% (minimum 75%, Missing); amygdala: 55.0612% (minimum 75%, Missing); basal ganglia: 59.7105% (minimum 75%, Missing); cerebellum: 67.5307% (minimum 75%, Missing); cerebral cortex: 45.2055% (minimum 75%, Missing); choroid plexus: 71.7391% (minimum 75%, Missing); colon: 68.9415% (minimum 70%, Missing); duodenum: 71.2230% (minimum 75%, Missing); esophagus: 63.7066% (minimum 70%, Missing); hippocampal formation: 55.3073% (minimum 75%, Missing); hypothalamus: 61.7207% (minimum 75%, Missing); kidney: 60.8108% (minimum 75%, Missing); lung: 63.0573% (minimum 75%, Missing); midbrain: 51.2953% (minimum 75%, Missing); pancreas: 62.5000% (minimum 75%, Missing); parathyroid gland: 65.1316% (minimum 70%, Missing); retina: 58.0986% (minimum 75%, Missing); skeletal muscle: 51.8325% (minimum 60%, Enhanced); small intestine: 70.8155% (minimum 75%, Missing); spinal cord: 42.7461% (minimum 75%, Missing); thyroid gland: 55.9322% (minimum 65%, Missing); tongue: 55.8061% (minimum 70%, Missing); urinary bladder: 63.3803% (minimum 70%, Missing)",-0.090678,-0.141939,-0.322539,0,4,partial,66.3,39.2,39,"spinal cord: 66.3 nTPM (vital, limit 1); cerebral cortex: 60 nTPM (vital, limit 1); midbrain: 47 nTPM (vital, limit 1); skeletal muscle: 46 nTPM (vital, limit 6); amygdala: 40.4 nTPM (vital, limit 1); hippocampal formation: 40 nTPM (vital, limit 1); tongue: 39.2 nTPM (protected, limit 3); thyroid gland: 39 nTPM (manageable, limit 5); retina: 35.7 nTPM (vital, limit 1); basal ganglia: 33.4 nTPM (vital, limit 1); liver: 32 nTPM (vital, limit 6); kidney: 31.9 nTPM (vital, limit 1); adipose tissue: 31.2 nTPM (manageable, limit 30); hypothalamus: 30.7 nTPM (vital, limit 1); pancreas: 29.7 nTPM (vital, limit 1); lung: 29 nTPM (vital, limit 1); urinary bladder: 28.6 nTPM (protected, limit 3); esophagus: 28.2 nTPM (protected, limit 3); bone marrow: 26.6 nTPM (vital, limit 6); parathyroid gland: 26.5 nTPM (protected, limit 3); smooth muscle: 26.2 nTPM (vital, limit 6); cerebellum: 23.8 nTPM (vital, limit 1); colon: 22.3 nTPM (protected, limit 3); adrenal gland: 22 nTPM (vital, limit 1); heart muscle: 21.7 nTPM (vital, limit 6); small intestine: 20.4 nTPM (vital, limit 1); duodenum: 20 nTPM (vital, limit 1); choroid plexus: 19.5 nTPM (vital, limit 1); rectum: 19.1 nTPM (protected, limit 3); skin: 18.9 nTPM (manageable, limit 5); thymus: 18.8 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 3); lymph node: 13.4 nTPM (protected, limit 12); pituitary gland: 11.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Primary cancer-associated SPAG9 nomination; current expression gates apply,True,Primary cancer-associated SPAG9 nomination; current expression gates apply,False,,,SPAG9,current_adaptive,True,False,False,False,10.1158/1078-0432.CCR-06-2340,"Garg et al., Clinical Cancer Research (2007)",False,False,False,False,False,unchanged,
ENSG00000009335,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.6958% (minimum 65%, Missing); adrenal gland: 60.2837% (minimum 75%, Missing); amygdala: 70.8333% (minimum 75%, Missing); basal ganglia: 66.2338% (minimum 75%, Missing); bone marrow: 61.4458% (minimum 75%, Missing); cerebellum: 57.0470% (minimum 75%, Missing); cerebral cortex: 61.0048% (minimum 75%, Missing); choroid plexus: 65.7216% (minimum 75%, Missing); colon: 54.1401% (minimum 70%, Missing); duodenum: 56.7929% (minimum 75%, Missing); esophagus: 48.2955% (minimum 70%, Missing); heart muscle: 48.1132% (minimum 75%, Missing); hippocampal formation: 70.0549% (minimum 75%, Missing); hypothalamus: 71.2291% (minimum 75%, Missing); kidney: 56.5410% (minimum 75%, Missing); liver: 53.3473% (minimum 75%, Missing); lung: 58.0866% (minimum 75%, Missing); lymph node: 55.4348% (minimum 65%, Approved); midbrain: 70.0549% (minimum 75%, Missing); pancreas: 54.0254% (minimum 75%, Missing); parathyroid gland: 42.1488% (minimum 70%, Missing); pituitary gland: 70.2479% (minimum 75%, Missing); rectum: 53.1250% (minimum 70%, Missing); retina: 56.5410% (minimum 75%, Missing); salivary gland: 53.5714% (minimum 70%, Missing); skeletal muscle: 28.7162% (minimum 75%, Missing); skin: 55.7987% (minimum 65%, Missing); small intestine: 55.6769% (minimum 75%, Missing); smooth muscle: 47.5746% (minimum 70%, Approved); spinal cord: 66.7539% (minimum 75%, Missing); spleen: 59.3023% (minimum 65%, Missing); stomach: 55.5556% (minimum 70%, Missing); thymus: 58.4862% (minimum 65%, Missing); thyroid gland: 60.2837% (minimum 65%, Missing); tongue: 31.1736% (minimum 70%, Missing); urinary bladder: 48.4791% (minimum 70%, Missing)",-0.143042,-0.388264,-0.462838,0,7,partial,63.3,56.3,24.8,"skeletal muscle: 63.3 nTPM (vital, limit 1); tongue: 56.3 nTPM (protected, limit 3); parathyroid gland: 35 nTPM (protected, limit 3); smooth muscle: 28.1 nTPM (vital, limit 2); heart muscle: 27.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 3); urinary bladder: 27.1 nTPM (protected, limit 3); adipose tissue: 24.8 nTPM (manageable, limit 5); rectum: 22.5 nTPM (protected, limit 3); liver: 22.3 nTPM (vital, limit 1); salivary gland: 22.1 nTPM (protected, limit 3); pancreas: 21.7 nTPM (vital, limit 1); colon: 21.6 nTPM (protected, limit 3); lymph node: 20.5 nTPM (protected, limit 4); stomach: 20.4 nTPM (protected, limit 3); small intestine: 20.3 nTPM (vital, limit 1); skin: 20.2 nTPM (manageable, limit 5); retina: 19.6 nTPM (vital, limit 1); kidney: 19.6 nTPM (vital, limit 1); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 1); lung: 18.4 nTPM (vital, limit 1); thymus: 18.1 nTPM (manageable, limit 5); spleen: 17.5 nTPM (manageable, limit 5); adrenal gland: 16.8 nTPM (vital, limit 1); thyroid gland: 16.8 nTPM (manageable, limit 5); cerebral cortex: 16.3 nTPM (vital, limit 1); bone marrow: 16 nTPM (vital, limit 1); choroid plexus: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); spinal cord: 12.7 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,UBE3C,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000010072,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 54.6512% (minimum 75%, Missing); liver: 73.8220% (minimum 75%, Uncertain); lymph node: 69.4581% (minimum 70%, Missing); skeletal muscle: 63.2287% (minimum 75%, Uncertain)",0.0182464,-0.00541872,-0.203488,0,0,routine_complete,11.7,6.2,7,"bone marrow: 11.7 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); thymus: 7 nTPM (manageable, limit 5); lymph node: 6.2 nTPM (protected, limit 3); skin: 5.7 nTPM (manageable, limit 5); esophagus: 5.5 nTPM (protected, limit 3); tongue: 5.1 nTPM (protected, limit 3); liver: 5 nTPM (vital, limit 1); smooth muscle: 4.7 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 3); urinary bladder: 4.6 nTPM (protected, limit 3); kidney: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 3); spinal cord: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); rectum: 3.7 nTPM (protected, limit 3); lung: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); small intestine: 3.5 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 3); midbrain: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPRTN,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000010318,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347635,0.299239,0.24772,0,2,partial,4.6,5.5,4.9,"choroid plexus: 2.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PHF7,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000011590,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.29831,0.235294,0.237578,0,6,partial,1.6,3.3,2.6,"lymph node: 3.3 nTPM (protected, limit 3)",bone marrow / hematopoietic cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); skin 1 / Langerhans: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZBTB32,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000013573,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 63.3136% (minimum 75%, Missing); bone marrow: 27.0886% (minimum 75%, Missing); cerebellum: 54.8718% (minimum 75%, Missing); cerebral cortex: 73.2877% (minimum 75%, Missing); choroid plexus: 69.4805% (minimum 75%, Missing); colon: 53.5000% (minimum 70%, Missing); duodenum: 58.1522% (minimum 75%, Missing); esophagus: 53.5000% (minimum 70%, Missing); heart muscle: 67.7215% (minimum 75%, Missing); kidney: 54.3147% (minimum 75%, Missing); liver: 54.0404% (minimum 65%, Supported); lung: 64.4578% (minimum 75%, Missing); lymph node: 45.3390% (minimum 70%, Missing); pancreas: 38.6282% (minimum 75%, Missing); pituitary gland: 53.7688% (minimum 75%, Missing); rectum: 52.4510% (minimum 70%, Missing); retina: 62.5731% (minimum 75%, Missing); salivary gland: 56.3158% (minimum 70%, Missing); skeletal muscle: 50.9524% (minimum 75%, Missing); skin: 39.6296% (minimum 65%, Missing); small intestine: 45.1477% (minimum 75%, Missing); spleen: 44.2149% (minimum 65%, Missing); stomach: 53.5000% (minimum 70%, Missing); thymus: 31.3783% (minimum 65%, Missing); thyroid gland: 57.8378% (minimum 65%, Missing); tongue: 63.3136% (minimum 70%, Missing); urinary bladder: 61.4943% (minimum 70%, Missing)",-0.336217,-0.24661,-0.479114,0,7,partial,28.8,12.9,23.4,"bone marrow: 28.8 nTPM (vital, limit 1); thymus: 23.4 nTPM (manageable, limit 5); pancreas: 17 nTPM (vital, limit 1); skin: 16.3 nTPM (manageable, limit 5); spleen: 13.5 nTPM (manageable, limit 5); small intestine: 13 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 3); skeletal muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 3); stomach: 9.3 nTPM (protected, limit 3); colon: 9.3 nTPM (protected, limit 3); esophagus: 9.3 nTPM (protected, limit 3); pituitary gland: 9.2 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 3); kidney: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); salivary gland: 8.3 nTPM (protected, limit 3); thyroid gland: 7.8 nTPM (manageable, limit 5); duodenum: 7.7 nTPM (vital, limit 1); urinary bladder: 6.7 nTPM (protected, limit 3); retina: 6.4 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 3); lung: 5.9 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); heart muscle: 5.1 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DDX11,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000013810,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 46.9407% (minimum 75%, Missing); lymph node: 55.7321% (minimum 70%, Missing); thymus: 49.4461% (minimum 65%, Missing)",-0.155539,-0.142679,-0.280593,0,6,partial,55.5,39,50.2,"bone marrow: 55.5 nTPM (vital, limit 1); thymus: 50.2 nTPM (manageable, limit 5); lymph node: 39 nTPM (protected, limit 3); spleen: 21.5 nTPM (manageable, limit 5); esophagus: 14.4 nTPM (protected, limit 3); small intestine: 12.5 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 3); colon: 9.6 nTPM (protected, limit 3); lung: 6.3 nTPM (vital, limit 6); duodenum: 5.9 nTPM (vital, limit 1); skin: 5.4 nTPM (manageable, limit 5); stomach: 5 nTPM (protected, limit 3); urinary bladder: 4.3 nTPM (protected, limit 3); choroid plexus: 4 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); tongue: 3.2 nTPM (protected, limit 3); kidney: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / extracellular matrix: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 2 / glandular cells: Low (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / extracellular matrix; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TACC3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000020256,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.7168% (minimum 65%, Missing); adrenal gland: 60.5042% (minimum 75%, Missing); amygdala: 64.8649% (minimum 75%, Missing); basal ganglia: 62.6087% (minimum 75%, Missing); bone marrow: 59.0164% (minimum 75%, Missing); cerebellum: 61.0169% (minimum 75%, Missing); cerebral cortex: 54.5455% (minimum 75%, Missing); choroid plexus: 67.9245% (minimum 75%, Missing); colon: 54.5455% (minimum 70%, Missing); duodenum: 53.3333% (minimum 75%, Missing); esophagus: 51.4286% (minimum 70%, Missing); heart muscle: 61.0169% (minimum 75%, Missing); hippocampal formation: 64.8649% (minimum 75%, Missing); hypothalamus: 64.8649% (minimum 75%, Missing); kidney: 61.0169% (minimum 75%, Missing); liver: 58.5366% (minimum 75%, Missing); lung: 62.6087% (minimum 75%, Missing); lymph node: 52.9412% (minimum 70%, Missing); midbrain: 65.4545% (minimum 75%, Missing); pancreas: 56.6929% (minimum 75%, Missing); parathyroid gland: 51.0638% (minimum 70%, Missing); pituitary gland: 61.5385% (minimum 75%, Missing); rectum: 57.1429% (minimum 70%, Missing); retina: 60.5042% (minimum 75%, Missing); salivary gland: 56.2500% (minimum 70%, Missing); skeletal muscle: 59.0164% (minimum 75%, Missing); skin: 40.2235% (minimum 65%, Missing); small intestine: 56.2500% (minimum 75%, Missing); smooth muscle: 57.6000% (minimum 75%, Missing); spinal cord: 66.0550% (minimum 75%, Missing); spleen: 57.1429% (minimum 65%, Missing); stomach: 55.8140% (minimum 70%, Missing); thymus: 50.3497% (minimum 65%, Missing); thyroid gland: 52.1739% (minimum 65%, Missing); tongue: 62.6087% (minimum 70%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",-0.247765,-0.189362,-0.216667,0,80,unavailable,6.3,6.9,10.7,"skin: 10.7 nTPM (manageable, limit 5); thymus: 7.1 nTPM (manageable, limit 5); parathyroid gland: 6.9 nTPM (protected, limit 3); esophagus: 6.8 nTPM (protected, limit 3); thyroid gland: 6.6 nTPM (manageable, limit 5); lymph node: 6.4 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 3); stomach: 5.7 nTPM (protected, limit 3); salivary gland: 5.6 nTPM (protected, limit 3); small intestine: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 3); spleen: 5.4 nTPM (manageable, limit 5); rectum: 5.4 nTPM (protected, limit 3); smooth muscle: 5.3 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 3); amygdala: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZFP64,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000021574,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.2258% (minimum 65%, Missing); adrenal gland: 62.8205% (minimum 75%, Missing); amygdala: 55.3672% (minimum 75%, Missing); basal ganglia: 57.9882% (minimum 75%, Missing); bone marrow: 49.2462% (minimum 75%, Missing); cerebellum: 55.3672% (minimum 75%, Missing); cerebral cortex: 42.9825% (minimum 75%, Missing); colon: 58.6826% (minimum 70%, Missing); duodenum: 57.3099% (minimum 75%, Missing); esophagus: 58.6826% (minimum 70%, Missing); heart muscle: 71.5328% (minimum 75%, Missing); hippocampal formation: 52.6882% (minimum 75%, Missing); hypothalamus: 54.7486% (minimum 75%, Missing); kidney: 63.2258% (minimum 75%, Missing); liver: 51.3089% (minimum 75%, Missing); lung: 61.6352% (minimum 75%, Missing); lymph node: 50.2564% (minimum 70%, Missing); midbrain: 51.3089% (minimum 75%, Missing); pancreas: 64.9007% (minimum 75%, Missing); parathyroid gland: 62.0253% (minimum 70%, Missing); pituitary gland: 70.0000% (minimum 75%, Missing); rectum: 57.3099% (minimum 70%, Missing); retina: 57.9882% (minimum 75%, Missing); skeletal muscle: 56.3218% (minimum 75%, Missing); skin: 57.6471% (minimum 65%, Missing); small intestine: 55.3672% (minimum 75%, Missing); smooth muscle: 57.9882% (minimum 75%, Missing); spinal cord: 43.7500% (minimum 75%, Missing); spleen: 58.6826% (minimum 65%, Missing); stomach: 60.8696% (minimum 70%, Missing); thymus: 41.7021% (minimum 65%, Missing); thyroid gland: 53.5519% (minimum 65%, Missing); tongue: 50.5155% (minimum 70%, Missing); urinary bladder: 57.6471% (minimum 70%, Missing)",-0.232979,-0.197436,-0.320175,0,3,partial,13,9.7,13.7,"thymus: 13.7 nTPM (manageable, limit 5); cerebral cortex: 13 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 9.7 nTPM (protected, limit 3); tongue: 9.6 nTPM (protected, limit 3); liver: 9.3 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); hypothalamus: 8.1 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 3); duodenum: 7.3 nTPM (vital, limit 1); skin: 7.2 nTPM (manageable, limit 5); urinary bladder: 7.2 nTPM (protected, limit 3); basal ganglia: 7.1 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); smooth muscle: 7.1 nTPM (vital, limit 1); colon: 6.9 nTPM (protected, limit 3); esophagus: 6.9 nTPM (protected, limit 3); spleen: 6.9 nTPM (manageable, limit 5); stomach: 6.3 nTPM (protected, limit 3); lung: 6.1 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 3); adrenal gland: 5.8 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); kidney: 5.7 nTPM (vital, limit 1); pancreas: 5.3 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 3); pituitary gland: 4.2 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPAST,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000024526,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 61.4173% (minimum 70%, Approved); lymph node: 62.4000% (minimum 65%, Approved); rectum: 69.6429% (minimum 70%, Missing); thymus: 49.6815% (minimum 65%, Missing)",-0.153185,-0.026,-0.0858268,0,6,partial,4.9,4.7,7.9,"thymus: 7.9 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 2); lymph node: 4.7 nTPM (protected, limit 4); rectum: 3.4 nTPM (protected, limit 3); duodenum: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DEPDC1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000025156,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 55.7576% (minimum 70%, Approved); cerebellum: 67.2761% (minimum 70%, Approved); choroid plexus: 69.5652% (minimum 75%, Missing); heart muscle: 62.1622% (minimum 70%, Approved); retina: 46.0576% (minimum 75%, Missing); skeletal muscle: 44.0191% (minimum 70%, Approved); tongue: 37.3604% (minimum 70%, Missing)",0.0289668,-0.326396,-0.289424,0,5,partial,46.8,61.7,17.4,"tongue: 61.7 nTPM (protected, limit 3); skeletal muscle: 46.8 nTPM (vital, limit 2); retina: 43.1 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 2); heart muscle: 22.4 nTPM (vital, limit 2); cerebellum: 17.9 nTPM (vital, limit 2); thymus: 17.4 nTPM (manageable, limit 5); choroid plexus: 16.1 nTPM (vital, limit 1); adrenal gland: 14.7 nTPM (vital, limit 2); parathyroid gland: 13.6 nTPM (protected, limit 4); smooth muscle: 13.5 nTPM (vital, limit 2); skin: 12.4 nTPM (manageable, limit 10); lymph node: 12.4 nTPM (protected, limit 4); cerebral cortex: 11.5 nTPM (vital, limit 2); colon: 11.2 nTPM (protected, limit 4); hypothalamus: 11.1 nTPM (vital, limit 1); pituitary gland: 10.3 nTPM (vital, limit 1); urinary bladder: 9.3 nTPM (protected, limit 4); stomach: 9.1 nTPM (protected, limit 4); hippocampal formation: 8.9 nTPM (vital, limit 1); small intestine: 8.8 nTPM (vital, limit 2); basal ganglia: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 2); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 8.4 nTPM (vital, limit 1); salivary gland: 8.2 nTPM (protected, limit 4); esophagus: 8 nTPM (protected, limit 4); duodenum: 6.7 nTPM (vital, limit 2); rectum: 6.7 nTPM (protected, limit 4); kidney: 6.5 nTPM (vital, limit 2); pancreas: 6.2 nTPM (vital, limit 2); liver: 5.3 nTPM (vital, limit 2)",,64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HSF2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000027644,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 59.3750% (minimum 75%, Missing); cerebellum: 73.0769% (minimum 75%, Missing); kidney: 33.9286% (minimum 75%, Missing); stomach: 52.7778% (minimum 70%, Missing)",0.141667,-0.172222,-0.410714,0,80,unavailable,3.7,1.7,0.5,"kidney: 3.7 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,INSRR,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000035499,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 52.7897% (minimum 75%, Missing); duodenum: 67.5824% (minimum 75%, Missing); lymph node: 58.2938% (minimum 70%, Missing); rectum: 69.4915% (minimum 70%, Missing); small intestine: 66.4865% (minimum 75%, Missing); thymus: 37.8462% (minimum 65%, Missing)",-0.271538,-0.117062,-0.222103,0,2,partial,11,8.8,20.2,"thymus: 20.2 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 3); small intestine: 6.2 nTPM (vital, limit 1); duodenum: 5.9 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 3); colon: 3.9 nTPM (protected, limit 3); kidney: 2.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DEPDC1B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,"Bradley et al., Nature Communications (2020);Bruggeman 2018;Jamin 2021",False,False,False,False,False,unchanged,
ENSG00000035720,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 31.7647% (minimum 75%, Missing); colon: 54.0000% (minimum 70%, Missing); duodenum: 61.3636% (minimum 75%, Missing); kidney: 23.2759% (minimum 75%, Missing); lymph node: 6.3529% (minimum 70%, Missing); rectum: 55.1020% (minimum 70%, Missing); small intestine: 25.4717% (minimum 75%, Missing); spleen: 14.6739% (minimum 65%, Missing); thymus: 30.0000% (minimum 65%, Missing)",-0.503261,-0.636471,-0.517241,0,11,partial,8.9,39.8,15.7,"lymph node: 39.8 nTPM (protected, limit 3); spleen: 15.7 nTPM (manageable, limit 5); kidney: 8.9 nTPM (vital, limit 1); small intestine: 7.9 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); bone marrow: 5.8 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / endocrine cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); duodenum / glands of Brunner: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); small intestine / paneth cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,STAP1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000039139,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 54.8387% (minimum 75%, Missing); lung: 68.0000% (minimum 75%, Missing); pituitary gland: 62.9630% (minimum 75%, Missing)",0.290698,0.279268,-0.201613,0,5,partial,2.8,0.7,0.9,"choroid plexus: 2.8 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAH5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000039600,True,compatible,,True,True,True,,0.34115,0.3,0.248726,0,1,partial,0.7,0.3,0.7,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SOX30,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000041353,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 57.5581% (minimum 75%, Missing); esophagus: 59.4595% (minimum 70%, Missing); lung: 74.1573% (minimum 75%, Missing); salivary gland: 59.2814% (minimum 70%, Missing); skin: 56.5714% (minimum 65%, Missing); stomach: 31.5287% (minimum 70%, Missing)",-0.0842857,-0.384713,-0.174419,0,3,partial,14.6,43,15.2,"stomach: 43 nTPM (protected, limit 3); skin: 15.2 nTPM (manageable, limit 5); cerebral cortex: 14.6 nTPM (vital, limit 1); salivary gland: 13.6 nTPM (protected, limit 3); esophagus: 13.5 nTPM (protected, limit 3); lung: 6.9 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 3); rectum: 5.1 nTPM (protected, limit 3); duodenum: 4.9 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 3); small intestine: 4.7 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RAB27B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000041515,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 41.6667% (minimum 65%, Missing); adrenal gland: 62.5000% (minimum 75%, Missing); amygdala: 58.8235% (minimum 75%, Missing); cerebellum: 71.4286% (minimum 75%, Missing); cerebral cortex: 28.5714% (minimum 75%, Missing); heart muscle: 55.5556% (minimum 75%, Missing); hippocampal formation: 52.6316% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); liver: 35.7143% (minimum 75%, Missing); pituitary gland: 37.0370% (minimum 75%, Missing); retina: 71.4286% (minimum 75%, Missing); smooth muscle: 71.4286% (minimum 75%, Missing)",-0.233333,0.133333,-0.464286,0,80,unavailable,2.5,0.2,1.4,"cerebral cortex: 2.5 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MYO16,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000042781,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.4286% (minimum 75%, Missing); heart muscle: 71.4286% (minimum 75%, Missing); liver: 6.9444% (minimum 75%, Missing); retina: 2.6178% (minimum 75%, Missing)",0.183333,0.3,-0.723822,0,80,unavailable,18.6,0,0.1,"retina: 18.6 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,USH2A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000042813,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.218619,0,1,partial,4.5,0,0.3,"retina: 4.5 nTPM (vital, limit 1)",,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZPBP,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000043355,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 16.9014% (minimum 75%, Missing); basal ganglia: 23.0769% (minimum 75%, Missing); cerebellum: 0.7678% (minimum 75%, Missing); cerebral cortex: 10.8108% (minimum 75%, Missing); choroid plexus: 5.7971% (minimum 75%, Missing); hippocampal formation: 13.1868% (minimum 75%, Missing); hypothalamus: 17.6471% (minimum 75%, Missing); midbrain: 24.4898% (minimum 75%, Missing); pituitary gland: 52.1739% (minimum 75%, Missing); retina: 33.3333% (minimum 75%, Missing); spinal cord: 17.3913% (minimum 75%, Missing)",0.273077,0.223077,-0.742322,0,80,unavailable,155.1,0.1,0.1,"cerebellum: 155.1 nTPM (vital, limit 1); choroid plexus: 19.5 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZIC2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000044459,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.2479% (minimum 65%, Uncertain); bone marrow: 50.6849% (minimum 75%, Missing); cerebellum: 67.8899% (minimum 75%, Missing); colon: 63.2479% (minimum 70%, Missing); liver: 42.0455% (minimum 75%, Missing); lung: 73.2673% (minimum 75%, Missing); parathyroid gland: 63.7931% (minimum 70%, Missing); smooth muscle: 63.2479% (minimum 75%, Missing); urinary bladder: 69.1589% (minimum 70%, Missing)",-0.0175214,-0.0675214,-0.329545,0,3,partial,10.2,4.3,4.3,"liver: 10.2 nTPM (vital, limit 1); bone marrow: 7.2 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 3); parathyroid gland: 4.2 nTPM (protected, limit 3); cerebellum: 3.5 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); lung: 2.7 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CNTLN,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000046774,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEC2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000047617,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 74.1667% (minimum 75%, Missing); retina: 4.2686% (minimum 75%, Missing)",0.122378,0.0416667,-0.707314,0,3,partial,199.6,3.1,5.4,"retina: 199.6 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); retina / outer plexiform layer: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ANO2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000047932,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 62.2951% (minimum 75%, Missing); amygdala: 66.4723% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 53.1469% (minimum 75%, Missing); cerebral cortex: 56.1576% (minimum 75%, Missing); colon: 55.7457% (minimum 70%, Missing); duodenum: 65.7061% (minimum 75%, Missing); esophagus: 66.0870% (minimum 70%, Missing); heart muscle: 51.7007% (minimum 75%, Missing); hippocampal formation: 63.6872% (minimum 75%, Missing); hypothalamus: 64.9573% (minimum 75%, Missing); kidney: 61.9565% (minimum 75%, Missing); liver: 58.9147% (minimum 75%, Missing); lung: 63.5097% (minimum 75%, Missing); lymph node: 53.9007% (minimum 70%, Missing); midbrain: 65.8960% (minimum 75%, Missing); pancreas: 64.9573% (minimum 75%, Missing); parathyroid gland: 51.5837% (minimum 65%, Approved); pituitary gland: 59.2208% (minimum 75%, Missing); rectum: 53.6471% (minimum 70%, Missing); retina: 63.5097% (minimum 75%, Missing); salivary gland: 62.1253% (minimum 70%, Missing); skeletal muscle: 60.0000% (minimum 75%, Missing); skin: 55.6098% (minimum 65%, Missing); small intestine: 60.9626% (minimum 75%, Missing); smooth muscle: 56.2963% (minimum 70%, Approved); spinal cord: 63.1579% (minimum 75%, Missing); spleen: 58.0153% (minimum 60%, Approved); stomach: 61.1260% (minimum 70%, Missing); thymus: 52.7778% (minimum 65%, Missing); thyroid gland: 49.5652% (minimum 65%, Missing); tongue: 57.7215% (minimum 70%, Missing); urinary bladder: 60.9626% (minimum 70%, Missing)",-0.154348,-0.163529,-0.232993,0,4,partial,21.3,21.4,23.2,"thyroid gland: 23.2 nTPM (manageable, limit 5); parathyroid gland: 21.4 nTPM (protected, limit 4); heart muscle: 21.3 nTPM (vital, limit 1); thymus: 20.4 nTPM (manageable, limit 5); cerebellum: 20.1 nTPM (vital, limit 1); rectum: 19.7 nTPM (protected, limit 3); lymph node: 19.5 nTPM (protected, limit 3); skin: 18.2 nTPM (manageable, limit 5); colon: 18.1 nTPM (protected, limit 3); cerebral cortex: 17.8 nTPM (vital, limit 1); smooth muscle: 17.7 nTPM (vital, limit 2); tongue: 16.7 nTPM (protected, limit 3); spleen: 16.5 nTPM (manageable, limit 10); liver: 15.9 nTPM (vital, limit 1); pituitary gland: 15.7 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (manageable, limit 10); small intestine: 14.6 nTPM (vital, limit 1); urinary bladder: 14.6 nTPM (protected, limit 3); stomach: 14.5 nTPM (protected, limit 3); kidney: 14 nTPM (vital, limit 1); salivary gland: 13.9 nTPM (protected, limit 3); adrenal gland: 13.8 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); lung: 13.1 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pancreas: 12.3 nTPM (vital, limit 1); hypothalamus: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 3); amygdala: 11.5 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GOPC,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000048545,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 1.1312% (minimum 75%, Missing)",0.35,0.3,-0.738688,0,0,routine_complete,734.2,0.1,0.1,"retina: 734.2 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GUCA1A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000049167,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.9481% (minimum 65%, Missing); adrenal gland: 57.1429% (minimum 75%, Missing); amygdala: 54.0541% (minimum 75%, Missing); basal ganglia: 54.7945% (minimum 75%, Missing); bone marrow: 60.6061% (minimum 75%, Missing); cerebellum: 72.7273% (minimum 75%, Missing); cerebral cortex: 58.8235% (minimum 75%, Missing); choroid plexus: 70.1754% (minimum 75%, Missing); colon: 55.5556% (minimum 70%, Missing); duodenum: 61.5385% (minimum 75%, Missing); esophagus: 59.7015% (minimum 70%, Missing); heart muscle: 54.0541% (minimum 75%, Missing); hippocampal formation: 57.1429% (minimum 75%, Missing); hypothalamus: 55.5556% (minimum 75%, Missing); kidney: 50.0000% (minimum 75%, Missing); liver: 54.0541% (minimum 75%, Missing); lung: 65.5738% (minimum 75%, Missing); lymph node: 62.5000% (minimum 70%, Missing); midbrain: 51.9481% (minimum 75%, Missing); pancreas: 60.6061% (minimum 75%, Missing); parathyroid gland: 53.3333% (minimum 70%, Missing); pituitary gland: 62.5000% (minimum 75%, Missing); rectum: 54.0541% (minimum 70%, Missing); retina: 52.6316% (minimum 75%, Missing); salivary gland: 60.6061% (minimum 70%, Missing); skeletal muscle: 57.9710% (minimum 75%, Missing); skin: 63.4921% (minimum 65%, Missing); small intestine: 64.5161% (minimum 75%, Missing); smooth muscle: 54.7945% (minimum 75%, Missing); spinal cord: 50.0000% (minimum 75%, Missing); spleen: 57.1429% (minimum 65%, Missing); stomach: 61.5385% (minimum 70%, Missing); thymus: 50.0000% (minimum 65%, Missing); thyroid gland: 57.9710% (minimum 65%, Missing); tongue: 50.0000% (minimum 70%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",-0.15,-0.2,-0.25,0,80,unavailable,4,4,4,"tongue: 4 nTPM (protected, limit 3); spinal cord: 4 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 3); heart muscle: 3.4 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); amygdala: 3.4 nTPM (vital, limit 1); liver: 3.4 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); hippocampal formation: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ERCC8,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000049192,True,compatible,,True,True,True,,0.25,0.17,0.0326087,0,2,partial,0.6,0.7,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ADAMTS6,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,True,True,True,True,gained,selectivity_revised
ENSG00000049768,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lymph node: 47.1698% (minimum 70%, Missing); thymus: 43.1034% (minimum 65%, Missing)",-0.218966,-0.228302,0.0849315,0,2,partial,2.3,5.6,6.6,"thymus: 6.6 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 3)",lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FOXP3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000050030,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 50.0000% (minimum 75%, Missing); amygdala: 45.0000% (minimum 75%, Missing); basal ganglia: 37.5000% (minimum 75%, Missing); cerebellum: 33.3333% (minimum 75%, Missing); cerebral cortex: 23.0769% (minimum 75%, Missing); choroid plexus: 69.2308% (minimum 75%, Missing); colon: 52.9412% (minimum 70%, Missing); hippocampal formation: 47.3684% (minimum 75%, Missing); hypothalamus: 30.0000% (minimum 75%, Missing); kidney: 56.2500% (minimum 75%, Missing); midbrain: 64.2857% (minimum 75%, Missing); pancreas: 39.1304% (minimum 75%, Missing); parathyroid gland: 33.3333% (minimum 70%, Missing); pituitary gland: 34.6154% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 69.2308% (minimum 70%, Missing); small intestine: 69.2308% (minimum 75%, Missing); smooth muscle: 56.2500% (minimum 75%, Missing); stomach: 60.0000% (minimum 70%, Missing)",0.0423077,-0.366667,-0.519231,0,80,unavailable,3,1.8,0.4,"cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NEXMIF,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000051180,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 69.5266% (minimum 75%, Missing); lymph node: 68.7135% (minimum 70%, Missing); thymus: 60.7235% (minimum 65%, Missing)",-0.0427649,-0.0128655,-0.0547337,0,6,partial,10.3,10.7,15.2,"thymus: 15.2 nTPM (manageable, limit 5); lymph node: 10.7 nTPM (protected, limit 3); bone marrow: 10.3 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 3); colon: 8 nTPM (protected, limit 3); esophagus: 4 nTPM (protected, limit 3); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / sebaceous glands: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thymus / cortical cells: High (Enhanced); thymus / medullary cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / langerhans cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / hair follicles; skin 2 / langerhans cells; skin 2 / sebaceous glands; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RAD51,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000051341,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 26.2500% (minimum 75%, Missing); colon: 63.6364% (minimum 70%, Missing); duodenum: 65.6250% (minimum 75%, Missing); esophagus: 52.5000% (minimum 70%, Missing); lymph node: 43.7500% (minimum 70%, Missing); rectum: 52.5000% (minimum 70%, Missing); skin: 60.0000% (minimum 65%, Missing); small intestine: 70.0000% (minimum 75%, Missing); thymus: 32.8125% (minimum 65%, Missing)",-0.321875,-0.2625,-0.4875,0,80,unavailable,5.9,2.7,4.3,"bone marrow: 5.9 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,POLQ,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000054796,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPO11,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000055955,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 18.6364% (minimum 60%, Enhanced); amygdala: 68.3333% (minimum 75%, Missing); basal ganglia: 60.2941% (minimum 75%, Missing); bone marrow: 29.2857% (minimum 60%, Enhanced); cerebellum: 53.9474% (minimum 60%, Enhanced); cerebral cortex: 56.1644% (minimum 60%, Enhanced); choroid plexus: 60.2941% (minimum 75%, Missing); colon: 53.9474% (minimum 55%, Enhanced); heart muscle: 56.9444% (minimum 60%, Enhanced); hippocampal formation: 69.4915% (minimum 75%, Missing); hypothalamus: 70.6897% (minimum 75%, Missing); kidney: 44.0860% (minimum 60%, Enhanced); liver: 0.2263% (minimum 60%, Enhanced); lung: 46.5909% (minimum 60%, Enhanced); midbrain: 67.2131% (minimum 75%, Missing); pancreas: 7.9457% (minimum 60%, Enhanced); pituitary gland: 49.3976% (minimum 75%, Missing); retina: 56.1644% (minimum 75%, Missing); skeletal muscle: 9.5571% (minimum 60%, Enhanced); small intestine: 55.4054% (minimum 60%, Enhanced); spinal cord: 74.5455% (minimum 75%, Missing); spleen: 36.2832% (minimum 50%, Enhanced); stomach: 52.5641% (minimum 55%, Enhanced); thyroid gland: 44.5652% (minimum 50%, Enhanced); tongue: 60.2941% (minimum 70%, Missing); urinary bladder: 44.5652% (minimum 55%, Enhanced)",-0.137168,-0.104348,-0.597737,0,1,partial,1807.4,5.1,7.2,"liver: 1807.4 nTPM (vital, limit 6); pancreas: 47.5 nTPM (vital, limit 6); skeletal muscle: 38.8 nTPM (vital, limit 6); adrenal gland: 17.9 nTPM (vital, limit 6); bone marrow: 9.9 nTPM (vital, limit 6); pituitary gland: 4.2 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ITIH4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000056277,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.1625,0.10531,0.0277778,0,2,partial,2.6,2.2,2.1,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF280C,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000056291,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"thymus: 30.6931% (minimum 65%, Missing)",-0.343069,0.185714,0.0657895,0,80,unavailable,0.7,0.4,7,"thymus: 7 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NPFFR2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000057468,True,compatible,,True,True,True,,0.241304,0.231818,0.0539216,0,80,unavailable,1,0.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MSH4,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000062370,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.5686% (minimum 75%, Missing); cerebellum: 56.1538% (minimum 75%, Missing); cerebral cortex: 72.2772% (minimum 75%, Missing); duodenum: 74.4898% (minimum 75%, Missing); heart muscle: 68.8679% (minimum 75%, Missing); kidney: 73.0000% (minimum 75%, Missing); midbrain: 74.4898% (minimum 75%, Missing); parathyroid gland: 62.9310% (minimum 70%, Missing); pituitary gland: 68.8679% (minimum 75%, Missing); retina: 59.3496% (minimum 75%, Missing); small intestine: 73.7374% (minimum 75%, Missing); smooth muscle: 73.0000% (minimum 75%, Missing); spinal cord: 72.2772% (minimum 75%, Missing)",0.0460177,-0.0706897,-0.188462,0,0,routine_complete,5.7,4.3,4,"cerebellum: 5.7 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 3); heart muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 2); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF112,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000063127,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.302083,0.231702,0.105005,0,80,unavailable,15.5,6.7,4.6,"choroid plexus: 15.5 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); pancreas: 6.7 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 3); lung: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 3); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 3); stomach: 3.4 nTPM (protected, limit 3); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC6A16,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000063438,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.236051,0.231818,0.205508,0,80,unavailable,2.1,3.3,5.8,"skin: 5.8 nTPM (manageable, limit 5); spleen: 5.6 nTPM (manageable, limit 5); urinary bladder: 3.3 nTPM (protected, limit 3); cerebral cortex: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AHRR,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000063515,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 68.7500% (minimum 75%, Missing)",0.35,0.3,-0.0625,0,0,routine_complete,1,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GSC2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000064199,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.339001,0.299111,0.183167,0,9,partial,16.1,5.2,8.6,"hypothalamus: 16.1 nTPM (vital, limit 1); choroid plexus: 15.2 nTPM (vital, limit 1); basal ganglia: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); kidney: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 6); midbrain: 9.4 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); spinal cord: 5.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPA17,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000064703,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.284426,0.231034,0.174324,0,1,partial,8.5,3.8,4.7,"skeletal muscle: 8.5 nTPM (vital, limit 6); small intestine: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); urinary bladder: 3.8 nTPM (protected, limit 3); stomach: 3.7 nTPM (protected, limit 3); esophagus: 3.2 nTPM (protected, limit 3); basal ganglia: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DDX20,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000065328,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 18.0180% (minimum 75%, Missing); colon: 54.0541% (minimum 65%, Approved); duodenum: 57.1429% (minimum 70%, Approved); esophagus: 51.2821% (minimum 65%, Approved); lymph node: 29.8507% (minimum 70%, Missing); rectum: 48.7805% (minimum 65%, Approved); small intestine: 62.5000% (minimum 70%, Approved); thymus: 20.2020% (minimum 65%, Missing)",-0.44798,-0.401493,-0.56982,0,0,routine_complete,9.1,4.7,7.9,"bone marrow: 9.1 nTPM (vital, limit 1); thymus: 7.9 nTPM (manageable, limit 5); lymph node: 4.7 nTPM (protected, limit 3)",bone marrow / hematopoietic cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MCM10,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000065371,True,compatible,,True,True,True,,0.35,0.296772,0.248061,0,3,partial,0.6,6,1.5,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ROPN1,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,False,unchanged,
ENSG00000065609,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 22.4762% (minimum 75%, Missing); basal ganglia: 28.1623% (minimum 75%, Missing); cerebellum: 9.6405% (minimum 75%, Missing); cerebral cortex: 11.6832% (minimum 75%, Missing); choroid plexus: 54.1284% (minimum 75%, Missing); hippocampal formation: 21.3382% (minimum 75%, Missing); hypothalamus: 20.3098% (minimum 75%, Missing); midbrain: 28.3654% (minimum 75%, Missing); pituitary gland: 31.9783% (minimum 75%, Missing); retina: 11.7063% (minimum 75%, Missing); spinal cord: 38.9439% (minimum 75%, Missing)",0.325207,0.193939,-0.653595,0,5,partial,110.6,2.9,1.3,"cerebellum: 110.6 nTPM (vital, limit 1); cerebral cortex: 89.2 nTPM (vital, limit 1); retina: 89 nTPM (vital, limit 1); hypothalamus: 46.3 nTPM (vital, limit 1); hippocampal formation: 43.5 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); basal ganglia: 30.1 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); pituitary gland: 25.1 nTPM (vital, limit 1); spinal cord: 18.5 nTPM (vital, limit 1); choroid plexus: 10 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 6)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SNAP91,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000065883,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.0996% (minimum 65%, Uncertain); adrenal gland: 65.5172% (minimum 75%, Uncertain); basal ganglia: 74.6725% (minimum 75%, Missing); bone marrow: 38.5135% (minimum 75%, Uncertain); cerebellum: 59.5819% (minimum 75%, Uncertain); cerebral cortex: 63.5688% (minimum 75%, Uncertain); choroid plexus: 68.4000% (minimum 75%, Missing); colon: 60.6383% (minimum 70%, Uncertain); duodenum: 63.0996% (minimum 75%, Missing); esophagus: 57.7703% (minimum 70%, Missing); heart muscle: 65.2672% (minimum 75%, Missing); kidney: 59.5819% (minimum 75%, Missing); liver: 53.7736% (minimum 75%, Uncertain); lung: 61.2903% (minimum 75%, Uncertain); lymph node: 46.8493% (minimum 70%, Uncertain); pancreas: 59.5819% (minimum 75%, Uncertain); parathyroid gland: 53.1056% (minimum 70%, Missing); pituitary gland: 68.9516% (minimum 75%, Missing); rectum: 58.5616% (minimum 70%, Missing); retina: 48.1690% (minimum 75%, Missing); salivary gland: 59.7902% (minimum 70%, Uncertain); skeletal muscle: 61.2903% (minimum 75%, Uncertain); skin: 60.2113% (minimum 65%, Missing); small intestine: 60.4240% (minimum 75%, Missing); smooth muscle: 61.7329% (minimum 75%, Uncertain); spleen: 52.4540% (minimum 65%, Uncertain); stomach: 59.3750% (minimum 70%, Missing); thymus: 50.4425% (minimum 65%, Missing); thyroid gland: 47.7654% (minimum 65%, Uncertain); tongue: 57.5758% (minimum 70%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.172346,-0.231507,-0.364865,0,2,partial,27.3,19.4,18.7,"bone marrow: 27.3 nTPM (vital, limit 1); lymph node: 19.4 nTPM (protected, limit 3); thyroid gland: 18.7 nTPM (manageable, limit 5); retina: 18.4 nTPM (vital, limit 1); thymus: 16.8 nTPM (manageable, limit 5); spleen: 15.5 nTPM (manageable, limit 5); parathyroid gland: 15.1 nTPM (protected, limit 3); liver: 14.7 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 3); esophagus: 12.5 nTPM (protected, limit 3); rectum: 12.1 nTPM (protected, limit 3); stomach: 11.7 nTPM (protected, limit 3); cerebellum: 11.6 nTPM (vital, limit 1); pancreas: 11.6 nTPM (vital, limit 1); kidney: 11.6 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 3); urinary bladder: 11.4 nTPM (protected, limit 3); skin: 11.3 nTPM (manageable, limit 5); small intestine: 11.2 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 3); lung: 10.8 nTPM (vital, limit 1); skeletal muscle: 10.8 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); adipose tissue: 10 nTPM (manageable, limit 5); duodenum: 10 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CDK13,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000066032,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 44.2867% (minimum 75%, Missing); basal ganglia: 52.0254% (minimum 75%, Missing); cerebral cortex: 41.6932% (minimum 75%, Missing); hippocampal formation: 53.9539% (minimum 75%, Missing); hypothalamus: 63.1021% (minimum 75%, Missing); midbrain: 68.6583% (minimum 75%, Missing); retina: 45.6446% (minimum 75%, Missing)",0.35,0.3,-0.333068,0,3,partial,91.6,1.9,0.1,"cerebral cortex: 91.6 nTPM (vital, limit 1); amygdala: 82.4 nTPM (vital, limit 1); retina: 78 nTPM (vital, limit 1); basal ganglia: 60.4 nTPM (vital, limit 1); hippocampal formation: 55.9 nTPM (vital, limit 1); hypothalamus: 38.3 nTPM (vital, limit 1); midbrain: 29.9 nTPM (vital, limit 1); cerebellum: 12.2 nTPM (vital, limit 6); spinal cord: 10.7 nTPM (vital, limit 1); pituitary gland: 6.9 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1)",cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),51,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CTNNA2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000066185,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 73.8095% (minimum 75%, Missing)",0.203211,0.220792,-0.0119048,0,80,unavailable,9.9,2.4,4.8,"choroid plexus: 9.9 nTPM (vital, limit 1); kidney: 9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZMYND12,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000066279,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 23.6641% (minimum 75%, Missing); colon: 65.9574% (minimum 70%, Missing); duodenum: 60.7843% (minimum 75%, Missing); esophagus: 67.3913% (minimum 70%, Missing); lymph node: 37.8049% (minimum 70%, Missing); rectum: 63.2653% (minimum 70%, Missing); skin: 54.3860% (minimum 65%, Missing); small intestine: 63.2653% (minimum 75%, Missing); thymus: 15.8163% (minimum 65%, Missing)",-0.491837,-0.321951,-0.513359,0,80,unavailable,10,5.1,16.5,"thymus: 16.5 nTPM (manageable, limit 5); bone marrow: 10 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ASPM,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000066923,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.340421,0.298069,0.23289,0,3,partial,1.1,0.4,0.5,,heart muscle / cardiomyocytes: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,STAG3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000067646,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 46.9799% (minimum 75%, Missing); cerebellum: 70.7071% (minimum 75%, Missing); duodenum: 72.9167% (minimum 75%, Missing); esophagus: 61.4035% (minimum 70%, Uncertain); liver: 61.9469% (minimum 75%, Missing); pancreas: 73.6842% (minimum 75%, Missing); rectum: 58.8235% (minimum 70%, Missing); skeletal muscle: 67.9612% (minimum 75%, Missing); small intestine: 63.0631% (minimum 75%, Missing); tongue: 49.6454% (minimum 70%, Missing); urinary bladder: 69.3069% (minimum 70%, Missing)",0.0716495,-0.203546,-0.280201,0,4,partial,7.9,7.1,2.7,"bone marrow: 7.9 nTPM (vital, limit 1); tongue: 7.1 nTPM (protected, limit 3); rectum: 4.9 nTPM (protected, limit 3); esophagus: 4.4 nTPM (protected, limit 3); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 3); cerebellum: 2.9 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZFY,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000068489,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 18.7215% (minimum 75%, Missing); cerebral cortex: 69.4915% (minimum 75%, Missing); colon: 47.6744% (minimum 70%, Missing); duodenum: 39.4231% (minimum 75%, Missing); esophagus: 53.2468% (minimum 70%, Missing); lung: 65.0794% (minimum 75%, Missing); lymph node: 29.0780% (minimum 70%, Missing); rectum: 43.6170% (minimum 70%, Missing); retina: 71.9298% (minimum 75%, Missing); skin: 57.7465% (minimum 65%, Missing); small intestine: 46.0674% (minimum 75%, Missing); smooth muscle: 53.9474% (minimum 75%, Missing); spleen: 56.9444% (minimum 65%, Missing); stomach: 65.0794% (minimum 70%, Missing); thymus: 17.0124% (minimum 65%, Missing); urinary bladder: 67.2131% (minimum 70%, Missing)",-0.479876,-0.40922,-0.562785,0,80,unavailable,17.8,10,20,"thymus: 20 nTPM (manageable, limit 5); bone marrow: 17.8 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 3); small intestine: 4.8 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 3); esophagus: 3.6 nTPM (protected, limit 3); smooth muscle: 3.5 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRR11,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000068796,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 56.9212% (minimum 75%, Missing); lymph node: 59.7744% (minimum 70%, Missing); retina: 53.5354% (minimum 75%, Missing); spinal cord: 73.3846% (minimum 75%, Missing); thymus: 52.9412% (minimum 65%, Missing)",-0.120588,-0.102256,-0.214646,0,4,partial,41.4,32.1,42.4,"thymus: 42.4 nTPM (manageable, limit 5); retina: 41.4 nTPM (vital, limit 1); cerebral cortex: 36.1 nTPM (vital, limit 1); lymph node: 32.1 nTPM (protected, limit 3); urinary bladder: 19.5 nTPM (protected, limit 3); spleen: 18 nTPM (manageable, limit 5); spinal cord: 17.3 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); amygdala: 15.3 nTPM (vital, limit 1); hypothalamus: 14.7 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 3); colon: 13.3 nTPM (protected, limit 3); smooth muscle: 12.6 nTPM (vital, limit 2); bone marrow: 12.6 nTPM (vital, limit 1); thyroid gland: 12.2 nTPM (manageable, limit 10); basal ganglia: 12.2 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 3); parathyroid gland: 11.9 nTPM (protected, limit 3); adipose tissue: 11.5 nTPM (manageable, limit 5); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); lung: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 3); pituitary gland: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); kidney: 7.8 nTPM (vital, limit 2); adrenal gland: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 4); tongue: 6.5 nTPM (protected, limit 3); heart muscle: 6 nTPM (vital, limit 2); skin: 5.7 nTPM (manageable, limit 5); liver: 5.2 nTPM (vital, limit 2); skeletal muscle: 4.6 nTPM (vital, limit 2)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KIF2A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000068985,True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PAGE1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000069188,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.133333,0.195238,0.0603448,0,80,unavailable,2.2,1.1,2.6,"spinal cord: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SDK2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000069206,True,compatible,,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0.6,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ADAM7,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000069493,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 42.5087% (minimum 75%, Missing); choroid plexus: 73.9394% (minimum 75%, Missing); heart muscle: 70.5202% (minimum 75%, Missing); lung: 59.5122% (minimum 75%, Missing); lymph node: 18.7982% (minimum 70%, Missing); salivary gland: 65.5914% (minimum 70%, Missing); small intestine: 38.1250% (minimum 75%, Missing); spleen: 31.9372% (minimum 65%, Missing); stomach: 69.3182% (minimum 70%, Missing); thymus: 28.3063% (minimum 65%, Missing); urinary bladder: 68.5393% (minimum 70%, Missing)",-0.366937,-0.512018,-0.36875,0,2,partial,19.8,52.7,30.9,"lymph node: 52.7 nTPM (protected, limit 3); thymus: 30.9 nTPM (manageable, limit 5); spleen: 26 nTPM (manageable, limit 5); small intestine: 19.8 nTPM (vital, limit 1); bone marrow: 16.5 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); salivary gland: 6.4 nTPM (protected, limit 3); adipose tissue: 5.9 nTPM (manageable, limit 5); urinary bladder: 5.6 nTPM (protected, limit 3); stomach: 5.4 nTPM (protected, limit 3); heart muscle: 5.1 nTPM (vital, limit 1); colon: 4.6 nTPM (protected, limit 3); choroid plexus: 4.3 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 3); skeletal muscle: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CLEC2D,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000070601,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"retina: 11.9895% (minimum 75%, Missing); skeletal muscle: 69.4656% (minimum 75%, Missing); skin: 59.8684% (minimum 65%, Missing)",-0.0513158,0,-0.630105,0,2,partial,66.8,3.9,6.1,"retina: 66.8 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); skeletal muscle: 4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FRMPD1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000070886,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 38.1818% (minimum 75%, Missing); amygdala: 67.7419% (minimum 75%, Missing); basal ganglia: 63.6364% (minimum 75%, Missing); cerebellum: 65.6250% (minimum 75%, Missing); cerebral cortex: 53.8462% (minimum 75%, Missing); choroid plexus: 6.0870% (minimum 75%, Missing); hippocampal formation: 72.4138% (minimum 75%, Missing); hypothalamus: 43.7500% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 39.6226% (minimum 75%, Missing); pituitary gland: 58.3333% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); spinal cord: 72.4138% (minimum 75%, Missing); spleen: 31.8182% (minimum 65%, Missing)",-0.331818,0.3,-0.68913,0,80,unavailable,32.4,0,4.5,"choroid plexus: 32.4 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EPHA8,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000071539,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.113158,0.18685,0.197712,0,6,partial,5.9,7,9,"thymus: 9 nTPM (manageable, limit 5); colon: 3.7 nTPM (protected, limit 3); pituitary gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRIP13,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000071655,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.8261% (minimum 65%, Missing); adrenal gland: 54.3412% (minimum 75%, Missing); amygdala: 41.3686% (minimum 75%, Missing); basal ganglia: 49.1682% (minimum 75%, Missing); cerebellum: 50.9579% (minimum 75%, Missing); cerebral cortex: 38.8038% (minimum 75%, Missing); colon: 54.6201% (minimum 70%, Missing); esophagus: 56.3559% (minimum 70%, Missing); heart muscle: 47.6703% (minimum 75%, Missing); hippocampal formation: 41.2084% (minimum 75%, Missing); hypothalamus: 53.5750% (minimum 75%, Missing); kidney: 54.6763% (minimum 75%, Missing); liver: 47.9279% (minimum 65%, Supported); lung: 58.9147% (minimum 75%, Missing); midbrain: 52.5173% (minimum 75%, Missing); pancreas: 62.5882% (minimum 65%, Supported); pituitary gland: 52.2593% (minimum 75%, Missing); skeletal muscle: 42.6966% (minimum 75%, Missing); skin: 57.7007% (minimum 65%, Missing); small intestine: 61.2903% (minimum 75%, Missing); spinal cord: 57.7633% (minimum 75%, Missing); spleen: 52.2593% (minimum 65%, Missing); stomach: 58.4615% (minimum 70%, Missing); thyroid gland: 54.7889% (minimum 65%, Missing); urinary bladder: 57.2659% (minimum 70%, Missing)",-0.127407,-0.153799,-0.361962,0,3,partial,83.9,44.2,48.6,"cerebral cortex: 83.9 nTPM (vital, limit 1); hippocampal formation: 75.9 nTPM (vital, limit 1); amygdala: 75.4 nTPM (vital, limit 1); skeletal muscle: 71.4 nTPM (vital, limit 1); heart muscle: 58.4 nTPM (vital, limit 1); liver: 57.8 nTPM (vital, limit 3); basal ganglia: 55 nTPM (vital, limit 1); cerebellum: 51.2 nTPM (vital, limit 1); pituitary gland: 48.6 nTPM (vital, limit 1); spleen: 48.6 nTPM (manageable, limit 5); midbrain: 48.1 nTPM (vital, limit 1); hypothalamus: 46.1 nTPM (vital, limit 1); adrenal gland: 44.7 nTPM (vital, limit 1); colon: 44.2 nTPM (protected, limit 3); kidney: 44.1 nTPM (vital, limit 1); thyroid gland: 43.9 nTPM (manageable, limit 5); esophagus: 41.2 nTPM (protected, limit 3); urinary bladder: 39.7 nTPM (protected, limit 3); skin: 39 nTPM (manageable, limit 5); spinal cord: 38.9 nTPM (vital, limit 1); adipose tissue: 38.8 nTPM (manageable, limit 5); stomach: 37.8 nTPM (protected, limit 3); lung: 37.1 nTPM (vital, limit 1); small intestine: 33.6 nTPM (vital, limit 1); pancreas: 31.8 nTPM (vital, limit 3); salivary gland: 29.5 nTPM (protected, limit 6); bone marrow: 12.6 nTPM (vital, limit 1); lymph node: 9.4 nTPM (protected, limit 3); thymus: 8.8 nTPM (manageable, limit 5); duodenum: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.2 nTPM (protected, limit 3); smooth muscle: 7.1 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 3); tongue: 4.5 nTPM (protected, limit 3); choroid plexus: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Low (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Low (Supported); oral mucosa / squamous epithelial cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MBD3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000071909,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"parathyroid gland: 61.7117% (minimum 70%, Missing); retina: 70.6186% (minimum 75%, Missing)",0.319463,-0.0828829,-0.0438144,0,1,partial,5.7,8.5,1.2,"parathyroid gland: 8.5 nTPM (protected, limit 3); retina: 5.7 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 2)",caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MYO3B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000072364,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.4839% (minimum 65%, Missing); adrenal gland: 48.4962% (minimum 75%, Missing); amygdala: 71.0744% (minimum 75%, Missing); basal ganglia: 68.0739% (minimum 75%, Missing); bone marrow: 37.5000% (minimum 75%, Missing); cerebellum: 57.4610% (minimum 75%, Missing); cerebral cortex: 56.3319% (minimum 75%, Missing); colon: 59.1743% (minimum 70%, Missing); duodenum: 64.8241% (minimum 75%, Missing); esophagus: 49.9033% (minimum 70%, Missing); heart muscle: 61.8705% (minimum 75%, Missing); hippocampal formation: 70.8791% (minimum 75%, Missing); hypothalamus: 67.8947% (minimum 75%, Missing); kidney: 52.4390% (minimum 75%, Missing); liver: 55.7235% (minimum 75%, Missing); lung: 57.4610% (minimum 75%, Missing); lymph node: 63.0807% (minimum 70%, Missing); midbrain: 71.6667% (minimum 75%, Missing); pancreas: 51.7034% (minimum 75%, Missing); parathyroid gland: 42.3645% (minimum 70%, Missing); pituitary gland: 57.5893% (minimum 75%, Missing); rectum: 60.2804% (minimum 70%, Missing); retina: 35.9833% (minimum 75%, Missing); salivary gland: 58.2393% (minimum 70%, Missing); skeletal muscle: 51.2922% (minimum 75%, Missing); skin: 59.0389% (minimum 65%, Missing); small intestine: 63.8614% (minimum 75%, Missing); smooth muscle: 53.0864% (minimum 75%, Missing); spinal cord: 67.1875% (minimum 75%, Missing); spleen: 61.1374% (minimum 65%, Missing); stomach: 51.2922% (minimum 70%, Missing); thymus: 58.2393% (minimum 65%, Missing); thyroid gland: 44.4828% (minimum 65%, Missing); tongue: 51.1905% (minimum 70%, Missing); urinary bladder: 53.7500% (minimum 70%, Missing)",-0.205172,-0.276355,-0.390167,0,7,partial,45.9,35.1,32.2,"retina: 45.9 nTPM (vital, limit 1); bone marrow: 43 nTPM (vital, limit 1); parathyroid gland: 35.1 nTPM (protected, limit 3); thyroid gland: 32.2 nTPM (manageable, limit 5); adrenal gland: 27.4 nTPM (vital, limit 1); esophagus: 25.9 nTPM (protected, limit 3); tongue: 24.6 nTPM (protected, limit 3); stomach: 24.5 nTPM (protected, limit 3); skeletal muscle: 24.5 nTPM (vital, limit 1); pancreas: 24.1 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); smooth muscle: 22.8 nTPM (vital, limit 1); urinary bladder: 22.2 nTPM (protected, limit 3); adipose tissue: 20.7 nTPM (manageable, limit 5); liver: 20.5 nTPM (vital, limit 1); cerebral cortex: 20 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); pituitary gland: 19 nTPM (vital, limit 1); salivary gland: 18.5 nTPM (protected, limit 3); thymus: 18.5 nTPM (manageable, limit 5); skin: 17.9 nTPM (manageable, limit 5); colon: 17.8 nTPM (protected, limit 3); rectum: 17 nTPM (protected, limit 3); spleen: 16.4 nTPM (manageable, limit 5); heart muscle: 15.9 nTPM (vital, limit 1); lymph node: 15.1 nTPM (protected, limit 3); small intestine: 14.6 nTPM (vital, limit 1); duodenum: 14 nTPM (vital, limit 1); spinal cord: 12.6 nTPM (vital, limit 1); hypothalamus: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); midbrain: 10.2 nTPM (vital, limit 1); choroid plexus: 8.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AFF4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000072571,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 56.8085% (minimum 75%, Missing); lymph node: 60.1351% (minimum 70%, Missing); thymus: 50.1880% (minimum 65%, Missing)",-0.14812,-0.0986486,-0.181915,0,6,partial,20.3,17.7,26.5,"thymus: 26.5 nTPM (manageable, limit 5); bone marrow: 20.3 nTPM (vital, limit 1); lymph node: 17.7 nTPM (protected, limit 3); rectum: 8.5 nTPM (protected, limit 3); duodenum: 7.2 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 3); small intestine: 6.3 nTPM (vital, limit 6); stomach: 3.5 nTPM (protected, limit 3); cerebral cortex: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / sebaceous glands: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / sebaceous glands; skin 2 / cells in spinous layer; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HMMR,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000073146,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.215035,0,0,routine_complete,2.2,1.9,0.5,"cerebellum: 2.2 nTPM (vital, limit 2); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MOV10L1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000073598,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0.1,0.1,,,55,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FNDC8,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000075131,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 61.4198% (minimum 75%, Missing); lymph node: 68.3849% (minimum 70%, Missing); retina: 71.8412% (minimum 75%, Missing)",0.0736364,-0.0161512,-0.135802,0,2,partial,12.5,9.2,7.6,"bone marrow: 12.5 nTPM (vital, limit 1); lymph node: 9.2 nTPM (protected, limit 3); retina: 7.8 nTPM (vital, limit 1); thymus: 7.6 nTPM (manageable, limit 5); rectum: 5.1 nTPM (protected, limit 3); esophagus: 4.8 nTPM (protected, limit 3); tongue: 4.6 nTPM (protected, limit 3); colon: 4.6 nTPM (protected, limit 3); hypothalamus: 4.1 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 3); hippocampal formation: 3.6 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 3); pituitary gland: 3.1 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TIPIN,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000075218,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 38.8889% (minimum 75%, Missing); duodenum: 63.6364% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); lymph node: 43.7500% (minimum 70%, Missing); small intestine: 71.4286% (minimum 75%, Missing); thymus: 26.8199% (minimum 65%, Missing)",-0.381801,-0.2625,-0.361111,0,80,unavailable,11,9,19.1,"thymus: 19.1 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); lymph node: 9 nTPM (protected, limit 3); duodenum: 4 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GTSE1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000075388,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FGF4,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000075702,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 36.7577% (minimum 60%, Enhanced); tongue: 50.5306% (minimum 70%, Missing)",0.278036,-0.194694,-0.232423,0,6,partial,106.5,60.6,4.8,"skeletal muscle: 106.5 nTPM (vital, limit 6); tongue: 60.6 nTPM (protected, limit 3); heart muscle: 21.4 nTPM (vital, limit 6); retina: 6.5 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,WDR62,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000075886,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;family_exclusion,True,True,True,"heart muscle: 71.9664% (minimum 75%, Missing)",0.347205,0.298135,-0.0303361,0,80,unavailable,83.4,0.4,0.6,"heart muscle: 83.4 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TUBA3D,current_adaptive,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000076053,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.0414% (minimum 65%, Missing); adrenal gland: 64.3725% (minimum 75%, Missing); basal ganglia: 73.6111% (minimum 75%, Missing); bone marrow: 28.8566% (minimum 75%, Missing); cerebellum: 74.6479% (minimum 75%, Missing); colon: 55.5944% (minimum 70%, Missing); duodenum: 72.6027% (minimum 75%, Missing); esophagus: 55.0173% (minimum 70%, Missing); heart muscle: 62.3529% (minimum 75%, Missing); kidney: 56.3830% (minimum 75%, Missing); liver: 47.7477% (minimum 75%, Missing); lung: 54.4521% (minimum 75%, Missing); pancreas: 62.1094% (minimum 65%, Supported); parathyroid gland: 63.3466% (minimum 70%, Missing); pituitary gland: 69.4323% (minimum 75%, Missing); rectum: 59.5506% (minimum 70%, Missing); retina: 70.6667% (minimum 75%, Missing); salivary gland: 56.3830% (minimum 70%, Missing); skeletal muscle: 57.6087% (minimum 75%, Missing); skin: 60.2273% (minimum 65%, Missing); small intestine: 59.1078% (minimum 75%, Missing); smooth muscle: 60.2273% (minimum 75%, Missing); spinal cord: 71.9457% (minimum 75%, Missing); spleen: 61.8677% (minimum 65%, Missing); stomach: 57.4007% (minimum 70%, Missing); thymus: 51.7915% (minimum 65%, Missing); thyroid gland: 61.1538% (minimum 65%, Missing); tongue: 53.3557% (minimum 70%, Missing); urinary bladder: 56.5836% (minimum 70%, Missing)",-0.179586,-0.166443,-0.461434,0,8,partial,39.2,13.9,17.9,"bone marrow: 39.2 nTPM (vital, limit 1); adipose tissue: 17.9 nTPM (manageable, limit 5); liver: 17.4 nTPM (vital, limit 1); thymus: 14.8 nTPM (manageable, limit 5); tongue: 13.9 nTPM (protected, limit 3); lung: 13.3 nTPM (vital, limit 1); esophagus: 13 nTPM (protected, limit 3); colon: 12.7 nTPM (protected, limit 3); salivary gland: 12.3 nTPM (protected, limit 3); kidney: 12.3 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 3); stomach: 11.8 nTPM (protected, limit 3); skeletal muscle: 11.7 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); rectum: 10.8 nTPM (protected, limit 3); smooth muscle: 10.5 nTPM (vital, limit 1); skin: 10.5 nTPM (manageable, limit 5); thyroid gland: 10.1 nTPM (manageable, limit 5); spleen: 9.8 nTPM (manageable, limit 5); pancreas: 9.7 nTPM (vital, limit 3); heart muscle: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 3); adrenal gland: 8.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); retina: 6.6 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 3); spinal cord: 6.2 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hypothalamus: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / basal cells: Low (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Low (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / goblet cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Low (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RBM7,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000077274,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340463,0.238121,0.198835,0,80,unavailable,11.2,13.7,2,"salivary gland: 13.7 nTPM (protected, limit 3); stomach: 12.6 nTPM (protected, limit 3); kidney: 11.2 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 3); rectum: 8.3 nTPM (protected, limit 3); smooth muscle: 7.9 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 3); urinary bladder: 3.7 nTPM (protected, limit 3); skeletal muscle: 2.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CAPN6,current_adaptive,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000077279,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 42.4242% (minimum 75%, Missing); basal ganglia: 43.7500% (minimum 75%, Missing); cerebral cortex: 18.9189% (minimum 75%, Missing); hippocampal formation: 56.0000% (minimum 75%, Missing); hypothalamus: 42.4242% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); retina: 40.0000% (minimum 75%, Missing); spinal cord: 56.0000% (minimum 75%, Missing)",0.35,0.116667,-0.560811,0,2,partial,6,0.7,0.1,"cerebral cortex: 6 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / synapses: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Low (Enhanced); colon / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DCX,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000077327,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 49.1329% (minimum 75%, Missing)",0.34574,0.3,-0.258671,0,8,partial,96.8,1.7,0.4,"choroid plexus: 96.8 nTPM (vital, limit 1); pituitary gland: 14.2 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.9 nTPM (vital, limit 1); lung: 6.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPAG6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000077458,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 30.6050% (minimum 70%, Approved); duodenum: 65.9004% (minimum 70%, Approved); liver: 68.2540% (minimum 70%, Approved); lymph node: 50.7375% (minimum 70%, Missing); thymus: 55.4839% (minimum 65%, Missing)",-0.0951613,-0.192625,-0.39395,0,0,routine_complete,39,16.7,13.8,"bone marrow: 39 nTPM (vital, limit 2); lymph node: 16.7 nTPM (protected, limit 3); thymus: 13.8 nTPM (manageable, limit 5); duodenum: 8.9 nTPM (vital, limit 2); liver: 8 nTPM (vital, limit 2); small intestine: 6.2 nTPM (vital, limit 2); pancreas: 5.9 nTPM (vital, limit 2); stomach: 5.8 nTPM (protected, limit 4); retina: 5.2 nTPM (vital, limit 1); rectum: 4.9 nTPM (protected, limit 4); lung: 4.9 nTPM (vital, limit 2); adrenal gland: 4.9 nTPM (vital, limit 2); urinary bladder: 4.7 nTPM (protected, limit 4); colon: 4.7 nTPM (protected, limit 4); salivary gland: 4.5 nTPM (protected, limit 4); smooth muscle: 4.3 nTPM (vital, limit 2); heart muscle: 3.8 nTPM (vital, limit 2); skeletal muscle: 3.8 nTPM (vital, limit 2); cerebellum: 3.7 nTPM (vital, limit 2); cerebral cortex: 3.6 nTPM (vital, limit 2); tongue: 3.6 nTPM (protected, limit 3); kidney: 3 nTPM (vital, limit 2); spinal cord: 2.6 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",lymph node / germinal center cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM76B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000077800,True,compatible,,True,True,True,,0.346497,0.3,0.248246,0,2,partial,0.2,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FKBP6,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000077935,True,compatible,,True,True,True,,0.3467,0.293421,0.25,0,8,partial,0.3,0.2,0.1,,,47,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SMC1B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000078043,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.240859,0.151369,0.0571693,0,4,partial,15.6,11.4,8,"skeletal muscle: 15.6 nTPM (vital, limit 1); cerebellum: 13.8 nTPM (vital, limit 6); parathyroid gland: 11.4 nTPM (protected, limit 3); retina: 10.5 nTPM (vital, limit 1); tongue: 9.8 nTPM (protected, limit 3); cerebral cortex: 8 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); skin: 7.4 nTPM (manageable, limit 5); bone marrow: 7.3 nTPM (vital, limit 6); basal ganglia: 6.9 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 3); pituitary gland: 5.5 nTPM (vital, limit 1); salivary gland: 5.3 nTPM (protected, limit 3); adrenal gland: 5.2 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 3); esophagus: 3.6 nTPM (protected, limit 3)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PIAS2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000078114,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 23.4962% (minimum 75%, Missing); basal ganglia: 22.8938% (minimum 75%, Missing); cerebellum: 22.6449% (minimum 70%, Approved); cerebral cortex: 24.1779% (minimum 70%, Approved); esophagus: 44.4840% (minimum 65%, Approved); heart muscle: 3.9872% (minimum 75%, Missing); hippocampal formation: 28.2805% (minimum 75%, Missing); hypothalamus: 26.7094% (minimum 75%, Missing); kidney: 49.6032% (minimum 75%, Missing); lung: 44.3262% (minimum 75%, Missing); midbrain: 25.3550% (minimum 75%, Missing); pancreas: 64.7668% (minimum 75%, Missing); pituitary gland: 36.7647% (minimum 75%, Missing); salivary gland: 41.6667% (minimum 65%, Approved); skin: 46.4684% (minimum 60%, Approved); spinal cord: 33.8753% (minimum 75%, Missing); thyroid gland: 37.5375% (minimum 65%, Missing)",-0.274625,-0.233333,-0.710128,0,1,partial,301,17.5,20.8,"heart muscle: 301 nTPM (vital, limit 1); cerebellum: 42.7 nTPM (vital, limit 2); basal ganglia: 42.1 nTPM (vital, limit 1); amygdala: 40.7 nTPM (vital, limit 1); cerebral cortex: 39.2 nTPM (vital, limit 2); midbrain: 36.8 nTPM (vital, limit 1); hypothalamus: 34.3 nTPM (vital, limit 1); hippocampal formation: 31.7 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); pituitary gland: 21.5 nTPM (vital, limit 1); thyroid gland: 20.8 nTPM (manageable, limit 5); salivary gland: 17.5 nTPM (protected, limit 4); lung: 15.7 nTPM (vital, limit 1); esophagus: 15.6 nTPM (protected, limit 4); skin: 14.4 nTPM (manageable, limit 10); kidney: 12.7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); adrenal gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NEBL,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000078177,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 45.9459% (minimum 75%, Missing); colon: 62.9630% (minimum 70%, Missing); duodenum: 61.8182% (minimum 75%, Missing); esophagus: 68.0000% (minimum 70%, Missing); kidney: 70.8333% (minimum 75%, Missing); liver: 38.6364% (minimum 75%, Missing); lung: 68.0000% (minimum 75%, Missing); lymph node: 49.2754% (minimum 70%, Missing); pancreas: 45.9459% (minimum 75%, Missing); pituitary gland: 73.9130% (minimum 75%, Missing); rectum: 61.8182% (minimum 70%, Missing); retina: 62.9630% (minimum 75%, Missing); salivary gland: 51.5152% (minimum 70%, Missing); small intestine: 62.9630% (minimum 75%, Missing); stomach: 65.3846% (minimum 70%, Missing); thymus: 23.6111% (minimum 65%, Missing); thyroid gland: 51.5152% (minimum 65%, Missing); urinary bladder: 64.1509% (minimum 70%, Missing)",-0.413889,-0.207246,-0.363636,0,3,partial,5.4,3.5,11,"thymus: 11 nTPM (manageable, limit 5); liver: 5.4 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); salivary gland: 3.2 nTPM (protected, limit 3); duodenum: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,N4BP2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000078487,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.247826,0.205702,0.128723,0,80,unavailable,5.7,4.3,4.7,"liver: 5.7 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 3); parathyroid gland: 4.2 nTPM (protected, limit 3); choroid plexus: 4 nTPM (vital, limit 1); lymph node: 3.8 nTPM (protected, limit 3); heart muscle: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); hippocampal formation: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 3); kidney: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZCWPW1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000078795,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.268605,0.208046,0.0321782,0,3,partial,2.2,0.8,0.7,"skeletal muscle: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PKD2L2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000079101,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 75.0000% (minimum 75%, Missing); choroid plexus: 22.5000% (minimum 75%, Missing); hippocampal formation: 71.6814% (minimum 75%, Missing); hypothalamus: 69.8276% (minimum 75%, Missing); midbrain: 74.3119% (minimum 75%, Missing); pituitary gland: 69.2308% (minimum 75%, Missing); retina: 2.7273% (minimum 75%, Missing); spinal cord: 69.8276% (minimum 75%, Missing)",0.0785714,0.160526,-0.722727,0,2,partial,288.9,3.3,5.9,"retina: 288.9 nTPM (vital, limit 1); choroid plexus: 27.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CLUL1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000079841,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 15.3257% (minimum 75%, Missing); basal ganglia: 33.3333% (minimum 75%, Missing); cerebellum: 5.9172% (minimum 60%, Enhanced); cerebral cortex: 13.6519% (minimum 75%, Missing); hippocampal formation: 17.4672% (minimum 75%, Missing); hypothalamus: 37.0370% (minimum 75%, Missing); midbrain: 46.5116% (minimum 75%, Missing); pituitary gland: 63.4921% (minimum 75%, Missing); retina: 36.0360% (minimum 75%, Missing); spinal cord: 58.8235% (minimum 75%, Missing)",0.35,0.116327,-0.613481,0,1,partial,63.6,2,0.2,"cerebellum: 63.6 nTPM (vital, limit 6); cerebral cortex: 25.3 nTPM (vital, limit 1); amygdala: 22.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",caudate / glial cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: High (Enhanced); hippocampus / glial cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RIMS1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000080007,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.339583,0.284456,0.2,0,2,partial,1.2,1.8,1.4,,lung / macrophages: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DDX43,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000080224,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.158081,0.0207207,0.0420792,0,80,unavailable,2.1,3.1,1.9,"colon: 3.1 nTPM (protected, limit 3); cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EPHA6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000080572,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 74.8387% (minimum 75%, Missing)",0.35,0.3,-0.0016129,0,7,partial,3.9,0,0.2,"choroid plexus: 3.9 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / goblet cells: High (Enhanced),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAAF6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000080815,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.7765% (minimum 60%, Approved); adrenal gland: 63.5644% (minimum 75%, Missing); amygdala: 55.9233% (minimum 75%, Missing); basal ganglia: 51.8578% (minimum 75%, Missing); bone marrow: 70.3947% (minimum 75%, Missing); cerebellum: 68.8841% (minimum 75%, Missing); cerebral cortex: 53.7688% (minimum 75%, Missing); choroid plexus: 62.8180% (minimum 75%, Missing); colon: 47.1366% (minimum 70%, Missing); duodenum: 45.2113% (minimum 75%, Missing); esophagus: 55.6326% (minimum 70%, Missing); heart muscle: 72.1348% (minimum 75%, Missing); hippocampal formation: 47.3451% (minimum 75%, Missing); hypothalamus: 58.3636% (minimum 75%, Missing); kidney: 55.1546% (minimum 75%, Missing); liver: 59.3346% (minimum 75%, Missing); lung: 56.9149% (minimum 75%, Missing); lymph node: 69.0323% (minimum 70%, Missing); midbrain: 44.8324% (minimum 75%, Missing); pancreas: 66.8750% (minimum 75%, Missing); parathyroid gland: 55.5363% (minimum 70%, Missing); pituitary gland: 74.6512% (minimum 75%, Missing); rectum: 49.1577% (minimum 70%, Missing); retina: 74.6512% (minimum 75%, Missing); salivary gland: 60.1124% (minimum 70%, Missing); skeletal muscle: 64.9798% (minimum 75%, Missing); skin: 49.3088% (minimum 65%, Missing); small intestine: 44.7075% (minimum 75%, Missing); smooth muscle: 61.1429% (minimum 75%, Missing); spinal cord: 28.3820% (minimum 75%, Missing); spleen: 63.8171% (minimum 65%, Missing); stomach: 58.1522% (minimum 70%, Missing); thymus: 62.5731% (minimum 65%, Missing); thyroid gland: 54.4992% (minimum 65%, Missing); tongue: 66.3223% (minimum 70%, Missing); urinary bladder: 56.2172% (minimum 70%, Missing)",-0.156912,-0.228634,-0.46618,0,5,partial,81,36,33,"spinal cord: 81 nTPM (vital, limit 1); small intestine: 39.7 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); duodenum: 38.9 nTPM (vital, limit 1); colon: 36 nTPM (protected, limit 3); hippocampal formation: 35.7 nTPM (vital, limit 1); rectum: 33.2 nTPM (protected, limit 3); skin: 33 nTPM (manageable, limit 5); basal ganglia: 29.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); thyroid gland: 26.8 nTPM (manageable, limit 5); kidney: 26.1 nTPM (vital, limit 1); parathyroid gland: 25.7 nTPM (protected, limit 3); esophagus: 25.6 nTPM (protected, limit 3); amygdala: 25.3 nTPM (vital, limit 1); urinary bladder: 25 nTPM (protected, limit 3); lung: 24.3 nTPM (vital, limit 1); stomach: 23.1 nTPM (protected, limit 3); hypothalamus: 22.9 nTPM (vital, limit 1); liver: 22 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (manageable, limit 10); salivary gland: 21.3 nTPM (protected, limit 3); smooth muscle: 20.4 nTPM (vital, limit 1); thymus: 19.2 nTPM (manageable, limit 5); choroid plexus: 19 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); spleen: 18.2 nTPM (manageable, limit 5); skeletal muscle: 17.3 nTPM (vital, limit 1); tongue: 16.3 nTPM (protected, limit 3); pancreas: 15.9 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); lymph node: 14.4 nTPM (protected, limit 3); bone marrow: 13.5 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PSEN1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000080839,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 68.7500% (minimum 75%, Missing); amygdala: 75.0000% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); bone marrow: 18.7500% (minimum 75%, Missing); cerebellum: 56.8966% (minimum 75%, Missing); cerebral cortex: 70.2128% (minimum 75%, Missing); colon: 55.0000% (minimum 70%, Missing); duodenum: 58.9286% (minimum 75%, Missing); esophagus: 54.0984% (minimum 70%, Missing); heart muscle: 66.0000% (minimum 75%, Missing); hippocampal formation: 75.0000% (minimum 75%, Missing); kidney: 67.3469% (minimum 75%, Missing); liver: 71.7391% (minimum 75%, Missing); lung: 61.1111% (minimum 75%, Missing); lymph node: 31.7308% (minimum 70%, Missing); midbrain: 75.0000% (minimum 75%, Missing); pancreas: 58.9286% (minimum 75%, Missing); parathyroid gland: 56.8966% (minimum 70%, Missing); pituitary gland: 75.0000% (minimum 75%, Missing); rectum: 49.2537% (minimum 70%, Missing); retina: 45.8333% (minimum 75%, Missing); skeletal muscle: 33.0000% (minimum 75%, Missing); skin: 51.5625% (minimum 65%, Missing); small intestine: 57.8947% (minimum 75%, Missing); smooth muscle: 55.0000% (minimum 75%, Missing); spinal cord: 68.7500% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 55.9322% (minimum 70%, Missing); thymus: 27.9661% (minimum 65%, Missing); thyroid gland: 55.9322% (minimum 65%, Missing); tongue: 30.2752% (minimum 70%, Missing); urinary bladder: 63.4615% (minimum 70%, Missing)",-0.370339,-0.397248,-0.5625,0,9,partial,14.3,7.6,8.5,"bone marrow: 14.3 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); tongue: 7.6 nTPM (protected, limit 3); lymph node: 7.1 nTPM (protected, limit 3); skeletal muscle: 6.7 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); smooth muscle: 2.7 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RBL1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000081842,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 42.8571% (minimum 75%, Missing); basal ganglia: 31.5789% (minimum 75%, Missing); cerebellum: 16.6667% (minimum 75%, Missing); cerebral cortex: 20.0000% (minimum 75%, Missing); hippocampal formation: 37.5000% (minimum 75%, Missing); hypothalamus: 30.0000% (minimum 75%, Missing); midbrain: 42.8571% (minimum 75%, Missing); pancreas: 37.5000% (minimum 60%, Enhanced); parathyroid gland: 30.0000% (minimum 55%, Enhanced); pituitary gland: 28.5714% (minimum 75%, Missing); retina: 35.2941% (minimum 75%, Missing); spinal cord: 31.5789% (minimum 75%, Missing)",0.25,-0.25,-0.583333,0,3,partial,3,1.4,0.2,"cerebellum: 3 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHA6,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000081985,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 71.9101% (minimum 75%, Missing); skeletal muscle: 65.3061% (minimum 75%, Missing)",0.140123,0.1,-0.0969388,0,80,unavailable,3.4,1.6,1.7,"skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IL12RB2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000083067,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 49.0000% (minimum 75%, Missing); basal ganglia: 56.9767% (minimum 75%, Missing); cerebellum: 27.3743% (minimum 60%, Enhanced); cerebral cortex: 56.9767% (minimum 60%, Enhanced); choroid plexus: 0.7187% (minimum 75%, Missing); hippocampal formation: 55.6818% (minimum 75%, Missing); hypothalamus: 48.5149% (minimum 75%, Missing); kidney: 24.6231% (minimum 75%, Missing); midbrain: 37.9845% (minimum 75%, Missing); pituitary gland: 63.6364% (minimum 75%, Missing); retina: 20.6751% (minimum 75%, Missing); spinal cord: 61.2500% (minimum 75%, Missing)",0.33,0.28,-0.742813,0,4,partial,676.9,0.4,0.8,"choroid plexus: 676.9 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); kidney: 15 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 6); midbrain: 8 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRPM3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000083290,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 64.3137% (minimum 75%, Missing); basal ganglia: 67.3511% (minimum 75%, Missing); cerebellum: 64.4401% (minimum 75%, Missing); cerebral cortex: 64.9505% (minimum 75%, Missing); choroid plexus: 73.5426% (minimum 75%, Missing); hippocampal formation: 64.8221% (minimum 75%, Missing); hypothalamus: 70.9957% (minimum 75%, Missing); midbrain: 62.0038% (minimum 75%, Missing); skeletal muscle: 69.0526% (minimum 75%, Missing); spinal cord: 47.7438% (minimum 75%, Missing); tongue: 69.9360% (minimum 70%, Missing)",0.112791,-0.000639659,-0.272562,0,1,partial,35.9,14.1,10.2,"spinal cord: 35.9 nTPM (vital, limit 1); midbrain: 20.1 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); cerebellum: 18.1 nTPM (vital, limit 1); hippocampal formation: 17.8 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); skeletal muscle: 14.7 nTPM (vital, limit 1); tongue: 14.1 nTPM (protected, limit 3); hypothalamus: 13.4 nTPM (vital, limit 1); parathyroid gland: 12.8 nTPM (protected, limit 3); choroid plexus: 11.8 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 3); adipose tissue: 10.2 nTPM (manageable, limit 5); smooth muscle: 9.2 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 3); lung: 8.2 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); pancreas: 7.3 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 3); spleen: 7 nTPM (manageable, limit 5); adrenal gland: 6.7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); thyroid gland: 6.2 nTPM (manageable, limit 5); esophagus: 6.1 nTPM (protected, limit 3); salivary gland: 5.7 nTPM (protected, limit 3); pituitary gland: 5.2 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); small intestine: 4.5 nTPM (vital, limit 1); rectum: 4.1 nTPM (protected, limit 3); liver: 3.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ULK2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000083817,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.1642% (minimum 75%, Missing); basal ganglia: 66.1765% (minimum 75%, Missing); bone marrow: 63.3803% (minimum 75%, Missing); cerebellum: 57.6923% (minimum 75%, Missing); cerebral cortex: 68.1818% (minimum 75%, Missing); choroid plexus: 64.2857% (minimum 75%, Missing); colon: 67.1642% (minimum 70%, Missing); esophagus: 59.2105% (minimum 70%, Missing); heart muscle: 63.3803% (minimum 75%, Missing); hypothalamus: 73.7705% (minimum 75%, Missing); kidney: 64.2857% (minimum 75%, Missing); liver: 69.2308% (minimum 75%, Missing); lung: 65.2174% (minimum 75%, Missing); lymph node: 62.5000% (minimum 70%, Missing); parathyroid gland: 51.1364% (minimum 70%, Missing); pituitary gland: 69.2308% (minimum 75%, Missing); rectum: 69.2308% (minimum 70%, Missing); retina: 55.5556% (minimum 75%, Missing); salivary gland: 68.1818% (minimum 70%, Missing); skeletal muscle: 64.2857% (minimum 75%, Missing); skin: 47.8723% (minimum 65%, Missing); small intestine: 73.7705% (minimum 75%, Missing); smooth muscle: 62.5000% (minimum 75%, Missing); spleen: 62.5000% (minimum 65%, Missing); stomach: 68.1818% (minimum 70%, Missing); thymus: 53.5714% (minimum 65%, Missing); thyroid gland: 56.2500% (minimum 65%, Missing); tongue: 60.8108% (minimum 70%, Missing); urinary bladder: 66.1765% (minimum 70%, Missing)",-0.171277,-0.188636,-0.194444,0,80,unavailable,3.6,4.3,4.9,"parathyroid gland: 4.3 nTPM (protected, limit 3); retina: 3.6 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 3); smooth muscle: 2.7 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF416,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000083844,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.9355% (minimum 65%, Missing); adrenal gland: 69.5652% (minimum 75%, Missing); bone marrow: 54.5455% (minimum 75%, Missing); cerebellum: 71.6418% (minimum 75%, Missing); duodenum: 67.6056% (minimum 75%, Missing); esophagus: 67.1329% (minimum 70%, Missing); heart muscle: 75.0000% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 65.3061% (minimum 75%, Missing); lung: 65.3061% (minimum 75%, Missing); lymph node: 58.1818% (minimum 70%, Missing); pancreas: 55.1724% (minimum 75%, Missing); parathyroid gland: 60.7595% (minimum 70%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); rectum: 69.0647% (minimum 70%, Missing); retina: 53.0387% (minimum 75%, Missing); salivary gland: 65.7534% (minimum 70%, Missing); skeletal muscle: 72.1805% (minimum 75%, Missing); skin: 59.2593% (minimum 65%, Missing); small intestine: 64.8649% (minimum 75%, Missing); smooth muscle: 65.7534% (minimum 75%, Missing); spleen: 54.5455% (minimum 65%, Missing); stomach: 57.4850% (minimum 70%, Missing); thymus: 55.4913% (minimum 65%, Missing); thyroid gland: 57.4850% (minimum 65%, Missing); urinary bladder: 69.0647% (minimum 70%, Missing)",-0.104545,-0.12515,-0.219613,0,80,unavailable,8.5,7.1,8,"retina: 8.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); spleen: 8 nTPM (manageable, limit 5); pancreas: 7.8 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); thyroid gland: 7.1 nTPM (manageable, limit 5); stomach: 7.1 nTPM (protected, limit 3); lymph node: 6.9 nTPM (protected, limit 3); skin: 6.6 nTPM (manageable, limit 5); parathyroid gland: 6.2 nTPM (protected, limit 3); adipose tissue: 5.9 nTPM (manageable, limit 5); small intestine: 5.2 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 3); smooth muscle: 5 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); duodenum: 4.6 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 3); urinary bladder: 4.3 nTPM (protected, limit 3); adrenal gland: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); cerebellum: 3.8 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 3); skeletal muscle: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF264,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000084693,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.221163,0.0949915,0.146172,0,2,partial,21.7,48.3,27.7,"parathyroid gland: 48.3 nTPM (protected, limit 3); thyroid gland: 27.7 nTPM (manageable, limit 5); kidney: 21.7 nTPM (vital, limit 1); salivary gland: 20.6 nTPM (protected, limit 3); skin: 19.9 nTPM (manageable, limit 5); esophagus: 17.7 nTPM (protected, limit 3); adrenal gland: 16.2 nTPM (vital, limit 1); retina: 15.8 nTPM (vital, limit 1); colon: 15.6 nTPM (protected, limit 3); thymus: 15.1 nTPM (manageable, limit 5); choroid plexus: 14.5 nTPM (vital, limit 1); pancreas: 14.5 nTPM (vital, limit 1); urinary bladder: 14.4 nTPM (protected, limit 3); smooth muscle: 14.1 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); heart muscle: 12.2 nTPM (vital, limit 1); stomach: 11.4 nTPM (protected, limit 3); rectum: 11.1 nTPM (protected, limit 3); lung: 10.8 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 3); small intestine: 9.6 nTPM (vital, limit 1); duodenum: 8.6 nTPM (vital, limit 1); adipose tissue: 8.5 nTPM (manageable, limit 5); spleen: 8.3 nTPM (manageable, limit 5); cerebral cortex: 8 nTPM (vital, limit 1); basal ganglia: 7.7 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); liver: 7 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 3); cerebellum: 5.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AGBL5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000085840,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 14.8810% (minimum 75%, Missing); colon: 60.2410% (minimum 70%, Missing); esophagus: 64.9351% (minimum 70%, Missing); lymph node: 43.4783% (minimum 70%, Missing); rectum: 56.1798% (minimum 70%, Missing); small intestine: 68.4932% (minimum 75%, Missing); thymus: 30.6748% (minimum 65%, Missing)",-0.343252,-0.265217,-0.60119,0,5,partial,28.6,6.5,11.3,"bone marrow: 28.6 nTPM (vital, limit 1); thymus: 11.3 nTPM (manageable, limit 5); lymph node: 6.5 nTPM (protected, limit 3); rectum: 3.9 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ORC1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000085999,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 63.8655% (minimum 75%, Missing); thymus: 50.3311% (minimum 65%, Missing)",-0.146689,0.0378641,-0.111345,0,3,partial,8.6,5.4,15,"thymus: 15 nTPM (manageable, limit 5); bone marrow: 8.6 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 3); esophagus: 5.2 nTPM (protected, limit 3); rectum: 4.5 nTPM (protected, limit 3); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RAD54L,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000086200,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.3003% (minimum 65%, Missing); adrenal gland: 70.2703% (minimum 75%, Missing); amygdala: 73.4982% (minimum 75%, Missing); basal ganglia: 73.2394% (minimum 75%, Missing); cerebral cortex: 70.9898% (minimum 75%, Missing); choroid plexus: 67.5325% (minimum 75%, Missing); esophagus: 64.1975% (minimum 65%, Approved); heart muscle: 59.4286% (minimum 75%, Missing); hippocampal formation: 70.5085% (minimum 75%, Missing); hypothalamus: 73.2394% (minimum 75%, Missing); kidney: 64.3963% (minimum 75%, Missing); liver: 65.2038% (minimum 75%, Missing); lung: 73.4982% (minimum 75%, Missing); lymph node: 67.3139% (minimum 70%, Missing); midbrain: 70.0337% (minimum 75%, Missing); pancreas: 71.2329% (minimum 75%, Missing); parathyroid gland: 61.5385% (minimum 65%, Approved); skeletal muscle: 63.2219% (minimum 70%, Approved); small intestine: 73.2394% (minimum 75%, Missing); smooth muscle: 66.2420% (minimum 70%, Approved); spinal cord: 70.7483% (minimum 75%, Missing); spleen: 61.5385% (minimum 65%, Missing); thyroid gland: 60.4651% (minimum 65%, Missing); tongue: 59.9424% (minimum 70%, Missing); urinary bladder: 61.7211% (minimum 65%, Approved)",-0.0769972,-0.100576,-0.155714,0,3,partial,14.2,13.9,15.5,"adipose tissue: 15.5 nTPM (manageable, limit 5); heart muscle: 14.2 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 3); thyroid gland: 13.6 nTPM (manageable, limit 5); spleen: 13 nTPM (manageable, limit 5); parathyroid gland: 13 nTPM (protected, limit 4); urinary bladder: 12.9 nTPM (protected, limit 4); skeletal muscle: 12.1 nTPM (vital, limit 2); esophagus: 11.6 nTPM (protected, limit 4); kidney: 11.5 nTPM (vital, limit 1); liver: 11.1 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 2); lymph node: 10.1 nTPM (protected, limit 3); choroid plexus: 10 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); colon: 8.9 nTPM (protected, limit 3); midbrain: 8.9 nTPM (vital, limit 1); adrenal gland: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); skin: 8.5 nTPM (manageable, limit 5); cerebral cortex: 8.5 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 3); stomach: 8.2 nTPM (protected, limit 3); salivary gland: 8.2 nTPM (protected, limit 4); hypothalamus: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); lung: 7.5 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); bone marrow: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IPO11,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000086288,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 45.2915% (minimum 60%, Enhanced)",0.321154,0.3,-0.147085,0,1,partial,12.2,0.5,1,"bone marrow: 12.2 nTPM (vital, limit 6)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NME8,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000086619,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 74.4292% (minimum 75%, Missing); liver: 60.9346% (minimum 75%, Missing); pancreas: 15.5460% (minimum 75%, Missing); parathyroid gland: 65.7258% (minimum 70%, Missing); stomach: 42.9513% (minimum 70%, Missing); thyroid gland: 52.3274% (minimum 65%, Missing)",-0.126726,-0.270487,-0.59454,0,3,partial,177.1,43.3,29.7,"pancreas: 177.1 nTPM (vital, limit 1); stomach: 43.3 nTPM (protected, limit 3); thyroid gland: 29.7 nTPM (manageable, limit 5); liver: 20.9 nTPM (vital, limit 1); parathyroid gland: 17 nTPM (protected, limit 3); cerebellum: 11.2 nTPM (vital, limit 1); duodenum: 10.7 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); salivary gland: 7.9 nTPM (protected, limit 3); spleen: 7.7 nTPM (manageable, limit 5); kidney: 7.5 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 3); thymus: 5.9 nTPM (manageable, limit 5); basal ganglia: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); adipose tissue: 5.2 nTPM (manageable, limit 5); spinal cord: 5 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); cerebral cortex: 4.8 nTPM (vital, limit 1); smooth muscle: 4.7 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 3); hypothalamus: 4.6 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); rectum: 3.4 nTPM (protected, limit 3); skeletal muscle: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ERO1B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000086717,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"spinal cord: 56.9038% (minimum 75%, Missing)",0.314539,0.285507,-0.180962,0,80,unavailable,10.3,0.2,0.5,"spinal cord: 10.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PPEF1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Jamin 2021;Loriot 2025 · preferential;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000087338,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.8554% (minimum 65%, Missing); adrenal gland: 71.9457% (minimum 75%, Missing); bone marrow: 54.0816% (minimum 75%, Missing); cerebellum: 68.8312% (minimum 75%, Missing); cerebral cortex: 73.9535% (minimum 75%, Missing); choroid plexus: 57.6087% (minimum 75%, Missing); colon: 60.4563% (minimum 70%, Missing); duodenum: 50.6369% (minimum 75%, Missing); esophagus: 66.5272% (minimum 70%, Missing); hippocampal formation: 74.2991% (minimum 75%, Missing); kidney: 58.8889% (minimum 75%, Missing); liver: 60.6870% (minimum 75%, Missing); lung: 67.9487% (minimum 75%, Missing); lymph node: 57.6087% (minimum 70%, Missing); midbrain: 73.9535% (minimum 75%, Missing); pancreas: 64.6341% (minimum 75%, Missing); parathyroid gland: 46.2209% (minimum 65%, Approved); pituitary gland: 71.6216% (minimum 75%, Missing); rectum: 57.4007% (minimum 70%, Missing); retina: 72.6027% (minimum 75%, Missing); salivary gland: 63.6000% (minimum 70%, Missing); small intestine: 55.5944% (minimum 75%, Missing); smooth muscle: 72.2727% (minimum 75%, Missing); spinal cord: 74.2991% (minimum 75%, Missing); spleen: 64.1129% (minimum 65%, Missing); stomach: 65.7025% (minimum 70%, Missing); thymus: 46.9027% (minimum 65%, Missing); thyroid gland: 64.1129% (minimum 65%, Missing); urinary bladder: 66.5272% (minimum 70%, Missing)",-0.180973,-0.187791,-0.243631,0,5,partial,15.5,18.5,18,"parathyroid gland: 18.5 nTPM (protected, limit 4); thymus: 18 nTPM (manageable, limit 5); duodenum: 15.5 nTPM (vital, limit 1); bone marrow: 13.5 nTPM (vital, limit 1); small intestine: 12.7 nTPM (vital, limit 1); rectum: 11.8 nTPM (protected, limit 3); choroid plexus: 11.7 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 3); kidney: 11.1 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 3); liver: 10.3 nTPM (vital, limit 1); salivary gland: 9.1 nTPM (protected, limit 3); adipose tissue: 9 nTPM (manageable, limit 5); spleen: 8.9 nTPM (manageable, limit 5); thyroid gland: 8.9 nTPM (manageable, limit 5); pancreas: 8.7 nTPM (vital, limit 1); skin: 8.5 nTPM (manageable, limit 5); stomach: 8.3 nTPM (protected, limit 3); urinary bladder: 8 nTPM (protected, limit 3); esophagus: 8 nTPM (protected, limit 3); lung: 7.5 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); pituitary gland: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); smooth muscle: 6.1 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); spinal cord: 5.5 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); tongue: 5.2 nTPM (protected, limit 3); amygdala: 5 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / goblet cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GMCL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000087586,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 66.4444% (minimum 75%, Missing); lymph node: 59.4433% (minimum 70%, Missing); thymus: 60.4040% (minimum 65%, Missing)",-0.0459596,-0.105567,-0.0855556,0,3,partial,15.1,20.4,19.6,"lymph node: 20.4 nTPM (protected, limit 3); thymus: 19.6 nTPM (manageable, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); rectum: 12.5 nTPM (protected, limit 3); duodenum: 11.6 nTPM (vital, limit 6); colon: 10.4 nTPM (protected, limit 3); small intestine: 9 nTPM (vital, limit 6); skeletal muscle: 8.4 nTPM (vital, limit 6); tongue: 7.9 nTPM (protected, limit 3); esophagus: 7.3 nTPM (protected, limit 3); liver: 4.9 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 3); retina: 2.9 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AURKA,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000088325,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 38.6010% (minimum 75%, Missing); esophagus: 69.9531% (minimum 70%, Missing); lymph node: 53.5009% (minimum 70%, Missing); rectum: 68.3486% (minimum 70%, Missing); thymus: 30.3154% (minimum 65%, Missing)",-0.346846,-0.164991,-0.36399,0,6,partial,47.4,25.9,68.5,"thymus: 68.5 nTPM (manageable, limit 5); bone marrow: 47.4 nTPM (vital, limit 1); lymph node: 25.9 nTPM (protected, limit 3); rectum: 13.8 nTPM (protected, limit 3); esophagus: 12.8 nTPM (protected, limit 3); colon: 11.3 nTPM (protected, limit 3); skin: 9.6 nTPM (manageable, limit 5); duodenum: 9.2 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 3); liver: 4.1 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); lung: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TPX2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000088727,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 37.5919% (minimum 75%, Missing); kidney: 71.8143% (minimum 75%, Missing)",0.116129,0.172703,-0.374081,0,0,routine_complete,110.4,9.7,20.3,"choroid plexus: 110.4 nTPM (vital, limit 1); kidney: 26.1 nTPM (vital, limit 1); thyroid gland: 20.3 nTPM (manageable, limit 5); hypothalamus: 19.5 nTPM (vital, limit 1); retina: 18.3 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebral cortex: 12.9 nTPM (vital, limit 1); pancreas: 12.4 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); bone marrow: 11.7 nTPM (vital, limit 1); basal ganglia: 11.6 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 3); spinal cord: 9.2 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 3); colon: 8.8 nTPM (protected, limit 3); salivary gland: 8.7 nTPM (protected, limit 3); lung: 8.4 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); rectum: 7.8 nTPM (protected, limit 3); adrenal gland: 7.2 nTPM (vital, limit 1); urinary bladder: 6.6 nTPM (protected, limit 3); adipose tissue: 6.3 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 3); spleen: 5.5 nTPM (manageable, limit 5); small intestine: 5.4 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 3); cerebellum: 4.6 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KIF9,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000088756,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.303046,0.276593,0.152644,0,4,partial,8.1,5.2,12.3,"kidney: 8.1 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ARHGAP28,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000088782,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.249905,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,DEFB127,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000089234,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 66.2944% (minimum 75%, Missing)",0.189332,0.129733,-0.0870558,0,4,partial,33.2,13.4,12.5,"bone marrow: 33.2 nTPM (vital, limit 1); skeletal muscle: 19.1 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 3); thymus: 12.5 nTPM (manageable, limit 5); skin: 12.4 nTPM (manageable, limit 5); lymph node: 10.3 nTPM (protected, limit 3); parathyroid gland: 10.2 nTPM (protected, limit 3); thyroid gland: 9.7 nTPM (manageable, limit 5); liver: 9.7 nTPM (vital, limit 1); heart muscle: 9.3 nTPM (vital, limit 1); colon: 9.2 nTPM (protected, limit 3); esophagus: 9.2 nTPM (protected, limit 3); cerebral cortex: 9.1 nTPM (vital, limit 1); choroid plexus: 9 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); urinary bladder: 8.9 nTPM (protected, limit 3); rectum: 8.9 nTPM (protected, limit 3); duodenum: 8.9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); spleen: 8.8 nTPM (manageable, limit 5); small intestine: 8.6 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 1); salivary gland: 8.2 nTPM (protected, limit 3); kidney: 8.2 nTPM (vital, limit 1); spinal cord: 8.1 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); pancreas: 7.9 nTPM (vital, limit 1); lung: 7.8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); stomach: 7.5 nTPM (protected, limit 3); basal ganglia: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BRAP,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000089505,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.257463,0.25,0.179664,0,80,unavailable,2.3,1.6,3.1,"cerebellum: 2.3 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CMTM1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000089685,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 33.6879% (minimum 75%, Missing); duodenum: 71.4286% (minimum 75%, Missing); esophagus: 60.5096% (minimum 70%, Missing); lymph node: 54.4413% (minimum 70%, Missing); small intestine: 72.2433% (minimum 75%, Missing); thymus: 32.2581% (minimum 65%, Missing)",-0.327419,-0.155587,-0.413121,0,7,partial,37.4,15.9,39.9,"thymus: 39.9 nTPM (manageable, limit 5); bone marrow: 37.4 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 3); esophagus: 12.4 nTPM (protected, limit 3); rectum: 7.7 nTPM (protected, limit 3); duodenum: 7.6 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); colon: 6.4 nTPM (protected, limit 3); skin: 5.7 nTPM (manageable, limit 5); stomach: 3.6 nTPM (protected, limit 3)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 2 / cells in basal layer; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BIRC5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000090402,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 8.6022% (minimum 70%, Missing); duodenum: 0.3010% (minimum 75%, Missing); rectum: 5.0633% (minimum 70%, Missing); small intestine: 0.3657% (minimum 75%, Missing)",0.35,-0.649367,-0.74699,0,6,partial,530,30,0,"duodenum: 530 nTPM (vital, limit 1); small intestine: 435.9 nTPM (vital, limit 1); rectum: 30 nTPM (protected, limit 3); colon: 17 nTPM (protected, limit 3)",duodenum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),75,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; appendix / enterocytes - Microvilli; lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SI,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000090612,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.5850% (minimum 65%, Missing); adrenal gland: 59.3548% (minimum 75%, Missing); basal ganglia: 74.7967% (minimum 75%, Missing); bone marrow: 72.4409% (minimum 75%, Missing); cerebellum: 72.4409% (minimum 75%, Missing); cerebral cortex: 58.2278% (minimum 75%, Missing); choroid plexus: 65.2482% (minimum 75%, Missing); colon: 63.0137% (minimum 70%, Missing); duodenum: 68.1481% (minimum 75%, Missing); esophagus: 59.7403% (minimum 70%, Missing); heart muscle: 68.6567% (minimum 75%, Missing); kidney: 50.5495% (minimum 75%, Missing); liver: 42.5926% (minimum 75%, Missing); lung: 63.0137% (minimum 75%, Missing); lymph node: 60.5263% (minimum 65%, Approved); pancreas: 64.3357% (minimum 75%, Missing); parathyroid gland: 42.2018% (minimum 70%, Missing); pituitary gland: 70.7692% (minimum 75%, Missing); rectum: 63.8889% (minimum 70%, Missing); retina: 44.2308% (minimum 75%, Missing); salivary gland: 63.0137% (minimum 70%, Missing); skin: 64.7887% (minimum 65%, Missing); small intestine: 64.7887% (minimum 75%, Missing); smooth muscle: 62.1622% (minimum 75%, Missing); spleen: 61.3333% (minimum 65%, Missing); stomach: 56.7901% (minimum 70%, Missing); thymus: 56.4417% (minimum 65%, Missing); thyroid gland: 46.9388% (minimum 65%, Missing); tongue: 66.1871% (minimum 70%, Missing); urinary bladder: 60.1307% (minimum 70%, Missing)",-0.180612,-0.277982,-0.324074,0,3,partial,12.4,12.6,10.4,"parathyroid gland: 12.6 nTPM (protected, limit 3); liver: 12.4 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (manageable, limit 5); kidney: 9 nTPM (vital, limit 1); thymus: 7.1 nTPM (manageable, limit 5); stomach: 7 nTPM (protected, limit 3); cerebral cortex: 6.6 nTPM (vital, limit 1); adrenal gland: 6.3 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 3); urinary bladder: 6.1 nTPM (protected, limit 3); lymph node: 6 nTPM (protected, limit 4); spleen: 5.8 nTPM (manageable, limit 5); smooth muscle: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (manageable, limit 5); lung: 5.4 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 3); salivary gland: 5.4 nTPM (protected, limit 3); rectum: 5.2 nTPM (protected, limit 3); pancreas: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 3); duodenum: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF268,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000090889,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 16.5414% (minimum 75%, Missing); colon: 37.9310% (minimum 70%, Missing); duodenum: 42.3077% (minimum 75%, Missing); esophagus: 38.5965% (minimum 70%, Missing); lymph node: 29.3333% (minimum 70%, Missing); rectum: 33.3333% (minimum 70%, Missing); skin: 51.1628% (minimum 65%, Missing); small intestine: 40.7407% (minimum 75%, Missing); smooth muscle: 64.7059% (minimum 70%, Approved); spleen: 48.8889% (minimum 65%, Missing); stomach: 56.4103% (minimum 70%, Missing); thymus: 15.1724% (minimum 65%, Missing)",-0.498276,-0.406667,-0.584586,0,3,partial,11.1,5.3,12.3,"thymus: 12.3 nTPM (manageable, limit 5); bone marrow: 11.1 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 3); rectum: 4.4 nTPM (protected, limit 3); colon: 3.6 nTPM (protected, limit 3); esophagus: 3.5 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KIF4A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000091651,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 47.9381% (minimum 75%, Missing); cerebral cortex: 74.4000% (minimum 75%, Missing); lymph node: 56.3636% (minimum 70%, Missing); thymus: 60.7843% (minimum 65%, Missing)",-0.0421569,-0.136364,-0.270619,0,8,partial,10.1,7.2,6,"bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 3); thymus: 6 nTPM (manageable, limit 5); esophagus: 3.9 nTPM (protected, limit 3); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / lymphocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ORC6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000092200,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 24.3243% (minimum 75%, Missing)",0.348267,0.29654,-0.506757,0,2,partial,179.2,0.5,1.4,"retina: 179.2 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Supported),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RPGRIP1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000092345,True,compatible,,True,True,True,,0.35,0.296134,0.25,0,6,partial,0.2,0.3,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DAZL,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000092853,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 33.5329% (minimum 75%, Missing); lymph node: 53.8462% (minimum 70%, Missing); retina: 45.9016% (minimum 75%, Missing); thymus: 42.1053% (minimum 65%, Missing)",-0.228947,-0.161538,-0.414671,0,80,unavailable,11.1,4.8,7.7,"bone marrow: 11.1 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); retina: 6.6 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CLSPN,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000093009,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 47.4895% (minimum 75%, Missing); lymph node: 67.1598% (minimum 70%, Missing); thymus: 53.4118% (minimum 65%, Missing)",-0.115882,-0.0284024,-0.275105,0,7,partial,25.1,11.1,19.8,"bone marrow: 25.1 nTPM (vital, limit 1); thymus: 19.8 nTPM (manageable, limit 5); lymph node: 11.1 nTPM (protected, limit 3); colon: 4.5 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibrohistiocytic cells; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CDC45,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000094804,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 26.7030% (minimum 75%, Missing); colon: 54.7486% (minimum 70%, Missing); duodenum: 57.3099% (minimum 75%, Missing); esophagus: 64.0523% (minimum 70%, Missing); lymph node: 37.9845% (minimum 70%, Missing); rectum: 53.8462% (minimum 70%, Missing); small intestine: 60.1227% (minimum 75%, Missing); smooth muscle: 73.1343% (minimum 75%, Missing); thymus: 37.6923% (minimum 65%, Missing)",-0.273077,-0.320155,-0.48297,0,1,partial,26.9,16,16.2,"bone marrow: 26.9 nTPM (vital, limit 1); thymus: 16.2 nTPM (manageable, limit 5); lymph node: 16 nTPM (protected, limit 3); rectum: 8.4 nTPM (protected, limit 3); colon: 8.1 nTPM (protected, limit 3); duodenum: 7.3 nTPM (vital, limit 1); small intestine: 6.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 3); urinary bladder: 4.2 nTPM (protected, limit 3); smooth muscle: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); liver: 2.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CDC6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000094916,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 64.4909% (minimum 75%, Missing); amygdala: 55.8824% (minimum 75%, Missing); basal ganglia: 57.7103% (minimum 75%, Missing); bone marrow: 59.3750% (minimum 75%, Missing); cerebellum: 60.2439% (minimum 75%, Missing); cerebral cortex: 48.8142% (minimum 75%, Missing); choroid plexus: 17.6429% (minimum 75%, Missing); heart muscle: 55.1339% (minimum 60%, Enhanced); hippocampal formation: 59.3750% (minimum 75%, Missing); hypothalamus: 53.4632% (minimum 75%, Missing); kidney: 59.8063% (minimum 75%, Missing); lung: 72.6471% (minimum 75%, Missing); lymph node: 57.3086% (minimum 70%, Missing); midbrain: 57.8454% (minimum 75%, Missing); pancreas: 71.8023% (minimum 75%, Missing); parathyroid gland: 49.8990% (minimum 70%, Missing); pituitary gland: 56.2642% (minimum 75%, Missing); retina: 52.6652% (minimum 75%, Missing); skin: 59.5181% (minimum 65%, Missing); small intestine: 74.3976% (minimum 75%, Missing); spinal cord: 54.8889% (minimum 75%, Missing); thymus: 44.9909% (minimum 65%, Missing); thyroid gland: 51.5658% (minimum 65%, Missing)",-0.200091,-0.20101,-0.573571,0,10,partial,115.3,24.8,30.2,"choroid plexus: 115.3 nTPM (vital, limit 1); thymus: 30.2 nTPM (manageable, limit 5); cerebral cortex: 25.9 nTPM (vital, limit 1); parathyroid gland: 24.8 nTPM (protected, limit 3); thyroid gland: 23.2 nTPM (manageable, limit 5); retina: 22.2 nTPM (vital, limit 1); hypothalamus: 21.5 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); heart muscle: 20.1 nTPM (vital, limit 6); amygdala: 19.5 nTPM (vital, limit 1); pituitary gland: 19.2 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 3); basal ganglia: 18.1 nTPM (vital, limit 1); midbrain: 18 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); hippocampal formation: 16.9 nTPM (vital, limit 1); skin: 16.8 nTPM (manageable, limit 5); kidney: 16.6 nTPM (vital, limit 1); cerebellum: 16.3 nTPM (vital, limit 1); adrenal gland: 13.6 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 6); rectum: 10.5 nTPM (protected, limit 3); smooth muscle: 10.4 nTPM (vital, limit 6); spleen: 10.4 nTPM (manageable, limit 5); colon: 10.2 nTPM (protected, limit 3); stomach: 10 nTPM (protected, limit 3); pancreas: 9.7 nTPM (vital, limit 1); lung: 9.3 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 3); small intestine: 8.5 nTPM (vital, limit 1); salivary gland: 8.3 nTPM (protected, limit 3); adipose tissue: 7.8 nTPM (manageable, limit 5); liver: 7.8 nTPM (vital, limit 6); tongue: 7.4 nTPM (protected, limit 3); duodenum: 7.3 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 1 / langerhans cells: Low (Enhanced); skin 1 / lymphocytes: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in granular layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / langerhans cells: Low (Enhanced); skin 2 / lymphocytes: Low (Enhanced); skin 2 / sebaceous glands: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / sebaceous glands; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CBX5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000095627,True,compatible,,True,True,True,,0.337013,0.274359,0.243464,0,1,partial,1.6,0.4,0.5,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TDRD1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,True,True,True,False,gained,selectivity_revised
ENSG00000095777,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 73.5294% (minimum 75%, Missing); retina: 25.0000% (minimum 75%, Missing)",0.227193,0.243396,-0.5,0,3,partial,15,0.3,0.7,"retina: 15 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pituitary gland / cells in anterior : High (Enhanced); retina / ganglion cells : Low (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced); retina / photoreceptor cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),61,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / keratinocytes; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MYO3A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000095794,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 60.6866% (minimum 75%, Missing)",0.227428,0.173657,-0.143134,0,18,partial,131.7,58,52.6,"adrenal gland: 131.7 nTPM (vital, limit 1); urinary bladder: 58 nTPM (protected, limit 12); liver: 57.9 nTPM (vital, limit 1); pituitary gland: 57.7 nTPM (vital, limit 1); kidney: 56.3 nTPM (vital, limit 1); choroid plexus: 55.7 nTPM (vital, limit 1); adipose tissue: 52.6 nTPM (manageable, limit 30); heart muscle: 47.7 nTPM (vital, limit 1); hypothalamus: 41.1 nTPM (vital, limit 1); cerebral cortex: 39.3 nTPM (vital, limit 6); amygdala: 38.6 nTPM (vital, limit 1); basal ganglia: 37 nTPM (vital, limit 1); spinal cord: 35.1 nTPM (vital, limit 1); midbrain: 34.7 nTPM (vital, limit 1); hippocampal formation: 34.4 nTPM (vital, limit 1); tongue: 29.4 nTPM (protected, limit 3); lung: 29.1 nTPM (vital, limit 1); thymus: 28.4 nTPM (manageable, limit 5); skeletal muscle: 28.1 nTPM (vital, limit 1); smooth muscle: 23.4 nTPM (vital, limit 6); colon: 23.3 nTPM (protected, limit 3); parathyroid gland: 22.9 nTPM (protected, limit 3); retina: 21.7 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 1); stomach: 19.7 nTPM (protected, limit 3); lymph node: 17 nTPM (protected, limit 12); esophagus: 16.8 nTPM (protected, limit 12); pancreas: 15.1 nTPM (vital, limit 1); small intestine: 15.1 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); salivary gland: 13.2 nTPM (protected, limit 3); rectum: 13 nTPM (protected, limit 3); skin: 8.5 nTPM (manageable, limit 5); duodenum: 8.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / extracellular matrix: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / extracellular matrix: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),111,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 1 / extracellular matrix; skin 1 / fibrohistiocytic cells; skin 2 / extracellular matrix; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CREM,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000099338,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.321338,0.29026,0.177052,0,80,unavailable,2.4,0.3,0.9,"cerebellum: 2.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CATSPERG,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000099399,True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0.1,0,0,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEB2,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000099721,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pancreas: 50.0000% (minimum 75%, Missing); thyroid gland: 25.0000% (minimum 65%, Missing)",-0.4,0.3,-0.25,0,80,unavailable,0.1,0,0.3,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AMELY,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000099840,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.346069,0.297222,0.210321,0,2,partial,17.8,3.8,4.4,"amygdala: 17.8 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); cerebral cortex: 15.5 nTPM (vital, limit 6); basal ganglia: 15.3 nTPM (vital, limit 1); midbrain: 14.4 nTPM (vital, limit 1); hippocampal formation: 13.4 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 6); cerebellum: 6.1 nTPM (vital, limit 6); kidney: 4.1 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IZUMO4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000099953,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.327417,0.264485,0.20189,0,0,routine_complete,9.1,5.1,3.7,"smooth muscle: 9.1 nTPM (vital, limit 2); heart muscle: 7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 2); small intestine: 5.9 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 3); parathyroid gland: 3.2 nTPM (protected, limit 3); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MMP11,current_adaptive,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000100027,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 74.8759% (minimum 75%, Missing)",0.191518,0.22402,-0.00124131,0,2,partial,25.3,6.2,14.2,"basal ganglia: 25.3 nTPM (vital, limit 1); skeletal muscle: 15.2 nTPM (vital, limit 1); thymus: 14.2 nTPM (manageable, limit 5); cerebral cortex: 12.1 nTPM (vital, limit 1); choroid plexus: 11.6 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); hippocampal formation: 7.8 nTPM (vital, limit 1); cerebellum: 7.4 nTPM (vital, limit 1); heart muscle: 7 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 3); hypothalamus: 6.2 nTPM (vital, limit 1); lymph node: 5.7 nTPM (protected, limit 3); lung: 5.4 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 3); parathyroid gland: 3.2 nTPM (protected, limit 3); colon: 3.2 nTPM (protected, limit 3); midbrain: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,YPEL1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000100121,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.18391,0.223372,0.16635,0,80,unavailable,2.2,2,4.8,"bone marrow: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GGTLC2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Gong 2021 · reproductive coding;Loriot 2025 · preferential,False,False,False,False,False,unchanged,
ENSG00000100206,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.132313,0.258333,0.0894161,0,2,partial,2.2,2.6,3.2,"heart muscle: 2.2 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DMC1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000100312,True,compatible,,True,True,True,,0.35,0.3,0.239437,0,3,partial,1.9,0.6,2.9,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ACR,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,False,gained,selectivity_revised
ENSG00000100478,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 55.8140% (minimum 75%, Missing); basal ganglia: 53.9326% (minimum 75%, Missing); bone marrow: 69.2308% (minimum 75%, Missing); cerebellum: 56.2500% (minimum 75%, Missing); cerebral cortex: 47.0588% (minimum 75%, Missing); colon: 63.7168% (minimum 70%, Missing); heart muscle: 67.2897% (minimum 75%, Missing); hippocampal formation: 55.5985% (minimum 75%, Missing); hypothalamus: 58.0645% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); midbrain: 63.7168% (minimum 75%, Missing); pancreas: 67.9245% (minimum 75%, Missing); pituitary gland: 64.0000% (minimum 75%, Missing); retina: 59.2593% (minimum 75%, Missing); skeletal muscle: 56.4706% (minimum 75%, Missing); smooth muscle: 69.5652% (minimum 75%, Missing); spinal cord: 65.4545% (minimum 75%, Missing)",0.0197674,-0.0628319,-0.279412,0,4,partial,16.2,8.2,7.1,"cerebral cortex: 16.2 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); hypothalamus: 10.4 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 3); pituitary gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.6 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 3); thyroid gland: 7.1 nTPM (manageable, limit 5); heart muscle: 7 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 3); salivary gland: 4.9 nTPM (protected, limit 3); tongue: 4.8 nTPM (protected, limit 3); liver: 4.7 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 3); small intestine: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 3); esophagus: 3.9 nTPM (protected, limit 3); rectum: 3.5 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AP4S1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000100479,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 18.4685% (minimum 75%, Missing); colon: 52.5641% (minimum 70%, Missing); duodenum: 63.0769% (minimum 75%, Uncertain); esophagus: 53.2468% (minimum 70%, Missing); liver: 56.1644% (minimum 75%, Uncertain); lymph node: 44.0860% (minimum 70%, Missing); rectum: 47.1264% (minimum 70%, Uncertain); retina: 53.9474% (minimum 75%, Missing); skin: 53.9474% (minimum 65%, Missing); small intestine: 53.2468% (minimum 75%, Uncertain); smooth muscle: 65.0794% (minimum 75%, Uncertain); stomach: 65.0794% (minimum 70%, Uncertain); thymus: 42.2680% (minimum 65%, Missing)",-0.22732,-0.25914,-0.565315,0,1,partial,18.1,5.2,5.6,"bone marrow: 18.1 nTPM (vital, limit 1); thymus: 5.6 nTPM (manageable, limit 5); lymph node: 5.2 nTPM (protected, limit 3); rectum: 4.6 nTPM (protected, limit 3); colon: 3.7 nTPM (protected, limit 3); esophagus: 3.6 nTPM (protected, limit 3); small intestine: 3.6 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,POLE2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000100485,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.1082% (minimum 60%, Approved); adrenal gland: 65.2174% (minimum 75%, Missing); amygdala: 65.2174% (minimum 75%, Missing); basal ganglia: 64.7482% (minimum 75%, Missing); bone marrow: 40.9091% (minimum 75%, Missing); cerebral cortex: 66.5025% (minimum 75%, Missing); colon: 61.6438% (minimum 70%, Missing); duodenum: 56.4854% (minimum 75%, Missing); esophagus: 63.0841% (minimum 70%, Missing); heart muscle: 56.6038% (minimum 75%, Missing); hippocampal formation: 63.9810% (minimum 75%, Missing); hypothalamus: 69.7674% (minimum 75%, Missing); kidney: 53.3597% (minimum 75%, Missing); liver: 68.0101% (minimum 70%, Approved); lung: 63.9810% (minimum 75%, Missing); lymph node: 65.8537% (minimum 70%, Missing); midbrain: 61.7849% (minimum 75%, Missing); pancreas: 63.8298% (minimum 75%, Missing); parathyroid gland: 41.6025% (minimum 70%, Missing); rectum: 61.7849% (minimum 70%, Missing); retina: 66.9975% (minimum 75%, Missing); salivary gland: 65.6934% (minimum 70%, Missing); skeletal muscle: 32.7670% (minimum 75%, Missing); skin: 61.2245% (minimum 65%, Missing); small intestine: 53.2544% (minimum 75%, Missing); smooth muscle: 60.9481% (minimum 75%, Missing); spinal cord: 56.3674% (minimum 75%, Missing); spleen: 60.9481% (minimum 65%, Missing); stomach: 66.9975% (minimum 70%, Missing); thymus: 62.9371% (minimum 65%, Missing); thyroid gland: 52.5292% (minimum 65%, Missing); tongue: 30.5776% (minimum 70%, Missing); urinary bladder: 65.5340% (minimum 70%, Missing)",-0.124708,-0.394224,-0.42233,0,6,partial,55.4,61.3,24.4,"tongue: 61.3 nTPM (protected, limit 3); skeletal muscle: 55.4 nTPM (vital, limit 1); bone marrow: 39 nTPM (vital, limit 1); parathyroid gland: 37.9 nTPM (protected, limit 3); thyroid gland: 24.4 nTPM (manageable, limit 5); small intestine: 23.7 nTPM (vital, limit 1); kidney: 23.6 nTPM (vital, limit 1); adipose tissue: 22.9 nTPM (manageable, limit 10); spinal cord: 20.9 nTPM (vital, limit 1); duodenum: 20.8 nTPM (vital, limit 1); heart muscle: 20.7 nTPM (vital, limit 1); spleen: 17.3 nTPM (manageable, limit 5); smooth muscle: 17.3 nTPM (vital, limit 1); skin: 17.1 nTPM (manageable, limit 5); colon: 16.8 nTPM (protected, limit 3); rectum: 16.7 nTPM (protected, limit 3); midbrain: 16.7 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); esophagus: 15.8 nTPM (protected, limit 3); pancreas: 15.3 nTPM (vital, limit 1); hippocampal formation: 15.2 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 1); basal ganglia: 14.7 nTPM (vital, limit 1); adrenal gland: 14.4 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); urinary bladder: 14.2 nTPM (protected, limit 3); salivary gland: 14.1 nTPM (protected, limit 3); lymph node: 14 nTPM (protected, limit 3); cerebral cortex: 13.6 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 3); retina: 13.3 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 2); hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 8.9 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SOS2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000100523,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 65.0000% (minimum 75%, Missing)",0.173691,0.149432,-0.1,0,4,partial,16.1,9.7,6.4,"retina: 16.1 nTPM (vital, limit 1); spinal cord: 9.4 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 6); cerebellum: 8.5 nTPM (vital, limit 1); midbrain: 7.5 nTPM (vital, limit 1); cerebral cortex: 7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); thymus: 6.4 nTPM (manageable, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); urinary bladder: 5.3 nTPM (protected, limit 3); pituitary gland: 5.2 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); tongue: 5.1 nTPM (protected, limit 3); heart muscle: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 3); parathyroid gland: 4.3 nTPM (protected, limit 3); colon: 3.7 nTPM (protected, limit 3); stomach: 3.7 nTPM (protected, limit 3); adrenal gland: 3.5 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DDHD1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000100526,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.218753,0.178295,0.0753509,0,80,unavailable,42.3,27.7,30.2,"bone marrow: 42.3 nTPM (vital, limit 1); thymus: 30.2 nTPM (manageable, limit 5); lymph node: 27.7 nTPM (protected, limit 3); rectum: 16.4 nTPM (protected, limit 3); colon: 13.5 nTPM (protected, limit 3); duodenum: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); choroid plexus: 12 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 3); smooth muscle: 7.2 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); urinary bladder: 5.6 nTPM (protected, limit 3); heart muscle: 5.1 nTPM (vital, limit 1); stomach: 4.9 nTPM (protected, limit 3); cerebral cortex: 4.4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 3); salivary gland: 3.2 nTPM (protected, limit 3); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CDKN3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000100565,True,compatible,,True,True,True,,0.305224,0.3,0.25,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRRC74A,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000100583,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"retina: 51.8272% (minimum 75%, Missing)",0.1625,0.171508,-0.231728,0,0,routine_complete,14.5,2.3,3.6,"retina: 14.5 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SAMD15,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000100593,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.299031,0.239918,0,3,partial,2.1,0.4,0.6,"basal ganglia: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Supported); colon / endothelial cells: Low (Supported),53,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ISM2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000100629,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 45.0450% (minimum 75%, Missing); lymph node: 52.0833% (minimum 70%, Missing); skeletal muscle: 73.5294% (minimum 75%, Missing); smooth muscle: 72.4638% (minimum 75%, Missing); thymus: 17.1233% (minimum 65%, Missing); urinary bladder: 69.4444% (minimum 70%, Missing)",-0.478767,-0.179167,-0.29955,0,0,routine_complete,6.1,4.6,24.2,"thymus: 24.2 nTPM (manageable, limit 5); bone marrow: 6.1 nTPM (vital, limit 1); lymph node: 4.6 nTPM (protected, limit 3); smooth muscle: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CEP128,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000100890,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.0733% (minimum 65%, Missing); adrenal gland: 49.8480% (minimum 75%, Missing); amygdala: 58.9928% (minimum 75%, Missing); basal ganglia: 56.3574% (minimum 75%, Missing); bone marrow: 57.7465% (minimum 75%, Missing); cerebellum: 69.1983% (minimum 75%, Missing); cerebral cortex: 59.6364% (minimum 75%, Missing); choroid plexus: 41.8367% (minimum 75%, Missing); colon: 45.9384% (minimum 70%, Missing); duodenum: 52.3962% (minimum 75%, Missing); esophagus: 46.8571% (minimum 70%, Missing); heart muscle: 55.2189% (minimum 75%, Missing); hippocampal formation: 61.1940% (minimum 75%, Missing); hypothalamus: 61.4232% (minimum 75%, Missing); kidney: 40.5941% (minimum 75%, Missing); liver: 40.4938% (minimum 75%, Missing); lung: 57.5439% (minimum 75%, Missing); lymph node: 44.2049% (minimum 70%, Missing); midbrain: 55.2189% (minimum 75%, Missing); pancreas: 61.4232% (minimum 75%, Missing); parathyroid gland: 46.8571% (minimum 70%, Missing); pituitary gland: 63.5659% (minimum 75%, Missing); rectum: 44.9315% (minimum 70%, Missing); retina: 73.2143% (minimum 75%, Missing); salivary gland: 56.3574% (minimum 70%, Missing); skeletal muscle: 52.9032% (minimum 70%, Approved); skin: 49.3976% (minimum 65%, Missing); small intestine: 53.7705% (minimum 75%, Missing); smooth muscle: 58.9928% (minimum 75%, Missing); spinal cord: 52.2293% (minimum 75%, Missing); spleen: 55.4054% (minimum 60%, Approved); stomach: 55.2189% (minimum 70%, Missing); thymus: 35.1931% (minimum 65%, Missing); thyroid gland: 52.0635% (minimum 65%, Missing); tongue: 49.8480% (minimum 70%, Missing); urinary bladder: 52.5641% (minimum 70%, Missing)",-0.298069,-0.257951,-0.345062,0,6,partial,24.1,20.7,30.2,"thymus: 30.2 nTPM (manageable, limit 5); liver: 24.1 nTPM (vital, limit 1); kidney: 24 nTPM (vital, limit 1); choroid plexus: 22.8 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 3); rectum: 20.1 nTPM (protected, limit 3); colon: 19.3 nTPM (protected, limit 3); parathyroid gland: 18.6 nTPM (protected, limit 3); esophagus: 18.6 nTPM (protected, limit 3); skin: 16.8 nTPM (manageable, limit 5); adrenal gland: 16.5 nTPM (vital, limit 1); tongue: 16.5 nTPM (protected, limit 3); thyroid gland: 15.1 nTPM (manageable, limit 5); spinal cord: 15 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 3); skeletal muscle: 14.6 nTPM (vital, limit 2); small intestine: 14.1 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 3); midbrain: 13.3 nTPM (vital, limit 1); heart muscle: 13.3 nTPM (vital, limit 1); spleen: 13.2 nTPM (manageable, limit 10); salivary gland: 12.7 nTPM (protected, limit 3); basal ganglia: 12.7 nTPM (vital, limit 1); lung: 12.1 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 1); smooth muscle: 11.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); adipose tissue: 10.9 nTPM (manageable, limit 5); hippocampal formation: 10.4 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRORP,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000101003,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 69.8413% (minimum 75%, Missing); cerebellum: 73.9496% (minimum 75%, Missing); esophagus: 68.2171% (minimum 70%, Missing); lymph node: 63.7681% (minimum 70%, Missing); thymus: 55.3459% (minimum 65%, Missing)",-0.0965409,-0.0623188,-0.0515873,0,6,partial,3.8,5,7.1,"thymus: 7.1 nTPM (manageable, limit 5); lymph node: 5 nTPM (protected, limit 3); esophagus: 4.1 nTPM (protected, limit 3); bone marrow: 3.8 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); cerebellum: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GINS1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000101057,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 14.2857% (minimum 75%, Missing); colon: 64.5299% (minimum 70%, Missing); duodenum: 68.9498% (minimum 75%, Missing); esophagus: 60.6426% (minimum 70%, Missing); lymph node: 21.7893% (minimum 70%, Missing); pancreas: 58.0769% (minimum 75%, Missing); rectum: 69.2661% (minimum 70%, Missing); small intestine: 66.5198% (minimum 75%, Missing); spleen: 35.6974% (minimum 65%, Missing); thymus: 31.7895% (minimum 65%, Missing)",-0.332105,-0.482107,-0.607143,0,1,partial,90.6,54.2,32.4,"bone marrow: 90.6 nTPM (vital, limit 1); lymph node: 54.2 nTPM (protected, limit 3); thymus: 32.4 nTPM (manageable, limit 5); spleen: 27.2 nTPM (manageable, limit 5); pancreas: 10.9 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 3); colon: 8.3 nTPM (protected, limit 3); small intestine: 7.6 nTPM (vital, limit 1); duodenum: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); stomach: 5.9 nTPM (protected, limit 3); urinary bladder: 3.4 nTPM (protected, limit 3); smooth muscle: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MYBL2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000101074,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 36.3636% (minimum 70%, Missing); duodenum: 16.0000% (minimum 75%, Missing); hypothalamus: 57.1429% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); small intestine: 14.8148% (minimum 75%, Missing); stomach: 50.0000% (minimum 55%, Enhanced)",0.3,-0.336364,-0.601852,0,9,partial,2.3,0.7,0.1,"small intestine: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced),75,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; appendix / goblet cells; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,R3HDML,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000101203,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 24.2424% (minimum 75%, Missing); basal ganglia: 35.8209% (minimum 75%, Missing); cerebellum: 55.8140% (minimum 75%, Missing); cerebral cortex: 21.0526% (minimum 75%, Missing); choroid plexus: 75.0000% (minimum 75%, Missing); hippocampal formation: 28.5714% (minimum 75%, Missing); hypothalamus: 42.8571% (minimum 75%, Missing); midbrain: 32.4324% (minimum 75%, Missing); pituitary gland: 70.5882% (minimum 75%, Missing); spinal cord: 36.3636% (minimum 75%, Missing)",0.15,0.223077,-0.539474,0,80,unavailable,9,0.2,0.6,"cerebral cortex: 9 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,COL20A1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000101251,True,compatible,,True,True,True,,0.35,0.3,0.235714,0,2,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SEL1L2,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000101276,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 73.8722% (minimum 75%, Missing); small intestine: 67.8756% (minimum 75%, Missing)",0.334962,0.129762,-0.0712435,0,1,partial,18.6,11.1,2.3,"small intestine: 18.6 nTPM (vital, limit 1); duodenum: 13.9 nTPM (vital, limit 1); colon: 11.1 nTPM (protected, limit 4); kidney: 10.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 3); midbrain: 6.4 nTPM (vital, limit 1); heart muscle: 5.9 nTPM (vital, limit 2); salivary gland: 5.9 nTPM (protected, limit 3); spinal cord: 5.4 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 3); cerebral cortex: 4.9 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 3); amygdala: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC52A3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000101353,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.255,0.115315,0.0637131,0,1,partial,5.6,4.1,1.9,"skeletal muscle: 5.6 nTPM (vital, limit 2); tongue: 4.1 nTPM (protected, limit 3); retina: 3.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); salivary gland / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MROH8,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000101435,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CST9L,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000101446,False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.245652,0.3,0.25,0,8,partial,0,0,1.2,,skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 1 / lymphocytes: High (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / lymphocytes: Medium (Enhanced),66,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin; skin 1 / fibrohistiocytic cells; skin 1 / lymphocytes; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,SPINT3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000101448,True,compatible,,True,True,True,,0.35,0.3,0.247504,0,1,partial,2.3,0.4,0.7,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EPPIN,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,False,unchanged,
ENSG00000101746,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 63.8743% (minimum 75%, Missing); basal ganglia: 58.3732% (minimum 75%, Missing); cerebellum: 53.9823% (minimum 75%, Missing); cerebral cortex: 54.9550% (minimum 75%, Missing); hippocampal formation: 68.5393% (minimum 75%, Missing); hypothalamus: 61.3065% (minimum 75%, Missing); pituitary gland: 61.0000% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing)",0.240511,0.245736,-0.210177,0,80,unavailable,10.4,0.7,1.5,"cerebellum: 10.4 nTPM (vital, limit 1); cerebral cortex: 10 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.6 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; lymph node; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NOL4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000101812,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"smooth muscle: 69.6970% (minimum 75%, Missing); thymus: 54.7619% (minimum 65%, Missing)",-0.102381,0.0666667,-0.0530303,0,80,unavailable,1,0.7,1.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,H2BW2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000101842,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"stomach: 19.6763% (minimum 70%, Missing)",0.335075,-0.503237,0.198665,0,4,partial,2.5,188.6,0.8,"stomach: 188.6 nTPM (protected, limit 3); urinary bladder: 8.6 nTPM (protected, limit 3); pituitary gland: 2.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",duodenum / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,VSIG1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000101883,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 53.6765% (minimum 70%, Approved)",0.301235,0.195706,-0.163235,0,2,partial,12.6,1.7,1.6,"cerebellum: 12.6 nTPM (vital, limit 2); choroid plexus: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 2); retina: 2.5 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RHOXF1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000101890,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 0.4866% (minimum 75%, Missing); thymus: 50.0000% (minimum 65%, Missing)",-0.15,0.3,-0.745134,0,80,unavailable,40.9,0,0.2,"retina: 40.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GUCY2F,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000101951,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349899,0.3,0.248281,0,0,routine_complete,23.3,0.6,0.3,"smooth muscle: 23.3 nTPM (vital, limit 6); choroid plexus: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PAGE4,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000101977,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 38.7863% (minimum 75%, Missing); amygdala: 73.5000% (minimum 75%, Missing); basal ganglia: 66.5158% (minimum 75%, Missing); cerebral cortex: 62.0253% (minimum 75%, Missing); hippocampal formation: 72.0588% (minimum 75%, Missing); hypothalamus: 55.8935% (minimum 75%, Missing); midbrain: 61.7647% (minimum 75%, Missing); retina: 62.2881% (minimum 75%, Missing); spinal cord: 67.1233% (minimum 75%, Missing)",0.28038,0.236306,-0.362137,0,80,unavailable,23.2,1,1.1,"adrenal gland: 23.2 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 9.1 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 1); retina: 8.9 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MCF2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000102021,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LUZP4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000102048,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 60.7748% (minimum 75%, Missing); liver: 59.7619% (minimum 60%, Enhanced); pancreas: 72.9651% (minimum 75%, Missing)",0.187671,0.250758,-0.142252,0,6,partial,16.9,4,11.4,"liver: 16.9 nTPM (vital, limit 6); kidney: 16.2 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1)",kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ASB9,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000102055,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.34711,0.298553,0.245671,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,PPP1R2C,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000102076,False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,248.2,0,0,"retina: 248.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OPN1LW,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000102098,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.122414,0.0185279,0.0171233,0,5,partial,6.2,8.5,3.3,"bone marrow: 6.2 nTPM (vital, limit 6); retina: 3.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); colon / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SCML2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000102243,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348985,0.299909,0.24294,0,2,partial,6.4,21.9,0.6,"urinary bladder: 21.9 nTPM (protected, limit 6); kidney: 6.4 nTPM (vital, limit 3); pituitary gland: 1.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,VGLL1,current_adaptive,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000102383,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 59.4595% (minimum 75%, Missing); amygdala: 68.7500% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 61.1111% (minimum 75%, Missing); cerebral cortex: 44.0000% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); heart muscle: 57.8947% (minimum 75%, Missing); hippocampal formation: 68.7500% (minimum 75%, Missing); hypothalamus: 53.6585% (minimum 75%, Missing); kidney: 59.4595% (minimum 75%, Missing); lung: 66.6667% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 68.7500% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing); pituitary gland: 68.7500% (minimum 75%, Missing); retina: 53.6585% (minimum 75%, Missing); salivary gland: 33.8462% (minimum 70%, Missing); smooth muscle: 61.1111% (minimum 70%, Approved); spinal cord: 62.8571% (minimum 75%, Missing); thyroid gland: 53.6585% (minimum 65%, Missing)",-0.113415,-0.361538,-0.31,0,4,partial,2.8,4.3,1.9,"salivary gland: 4.3 nTPM (protected, limit 3); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZDHHC15,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000102384,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 25.6757% (minimum 75%, Missing); cerebral cortex: 70.3704% (minimum 75%, Missing); colon: 48.7179% (minimum 70%, Missing); duodenum: 44.1860% (minimum 75%, Missing); esophagus: 48.7179% (minimum 70%, Missing); liver: 73.0769% (minimum 75%, Missing); lung: 73.0769% (minimum 75%, Missing); lymph node: 30.6452% (minimum 70%, Missing); rectum: 41.3043% (minimum 70%, Missing); retina: 48.7179% (minimum 75%, Missing); skin: 37.2549% (minimum 65%, Missing); small intestine: 50.0000% (minimum 75%, Missing); smooth muscle: 51.3514% (minimum 75%, Missing); spleen: 55.8824% (minimum 65%, Missing); stomach: 61.2903% (minimum 70%, Missing); thymus: 26.7606% (minimum 65%, Missing); urinary bladder: 65.5172% (minimum 70%, Missing)",-0.382394,-0.393548,-0.493243,0,80,unavailable,5.5,4.3,5.2,"bone marrow: 5.5 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 3); duodenum: 2.4 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CENPI,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000102387,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346753,0.239855,0.137283,0,4,partial,3.9,3.8,0.9,"choroid plexus: 3.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TAF7L,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000102543,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.2903% (minimum 65%, Uncertain); adrenal gland: 53.5211% (minimum 75%, Uncertain); amygdala: 64.9573% (minimum 75%, Missing); basal ganglia: 67.8571% (minimum 75%, Missing); bone marrow: 55.0725% (minimum 75%, Missing); cerebellum: 55.0725% (minimum 75%, Uncertain); cerebral cortex: 61.7886% (minimum 75%, Uncertain); choroid plexus: 62.8099% (minimum 75%, Missing); colon: 62.2951% (minimum 70%, Missing); duodenum: 71.6981% (minimum 75%, Uncertain); heart muscle: 64.4068% (minimum 75%, Uncertain); hippocampal formation: 65.5172% (minimum 75%, Missing); hypothalamus: 62.8099% (minimum 75%, Missing); kidney: 45.2381% (minimum 75%, Uncertain); liver: 49.0323% (minimum 75%, Uncertain); lung: 69.0909% (minimum 75%, Uncertain); midbrain: 65.5172% (minimum 75%, Missing); pancreas: 74.5098% (minimum 75%, Uncertain); parathyroid gland: 58.9147% (minimum 70%, Uncertain); pituitary gland: 70.3704% (minimum 75%, Missing); retina: 59.8425% (minimum 75%, Missing); salivary gland: 69.7248% (minimum 70%, Uncertain); skeletal muscle: 63.8655% (minimum 75%, Uncertain); small intestine: 72.3810% (minimum 75%, Uncertain); smooth muscle: 67.8571% (minimum 75%, Uncertain); spinal cord: 68.4685% (minimum 75%, Missing); stomach: 66.6667% (minimum 70%, Uncertain); thymus: 64.4068% (minimum 65%, Missing); thyroid gland: 45.5090% (minimum 65%, Uncertain); tongue: 60.3175% (minimum 70%, Missing); urinary bladder: 69.0909% (minimum 70%, Uncertain)",-0.19491,-0.110853,-0.297619,0,4,partial,9.2,5.3,9.1,"kidney: 9.2 nTPM (vital, limit 1); thyroid gland: 9.1 nTPM (manageable, limit 5); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); bone marrow: 6.2 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); parathyroid gland: 5.3 nTPM (protected, limit 3); retina: 5.1 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 3); cerebral cortex: 4.7 nTPM (vital, limit 1); colon: 4.6 nTPM (protected, limit 3); hypothalamus: 4.5 nTPM (vital, limit 1); choroid plexus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); basal ganglia: 3.6 nTPM (vital, limit 1); smooth muscle: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 3); salivary gland: 3.3 nTPM (protected, limit 3); pituitary gland: 3.2 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); esophagus: 3.1 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CDADC1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000102595,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.7778% (minimum 65%, Missing); adrenal gland: 69.9552% (minimum 75%, Missing); cerebral cortex: 74.6411% (minimum 75%, Missing); choroid plexus: 69.3333% (minimum 75%, Missing); heart muscle: 65.0000% (minimum 75%, Missing); hippocampal formation: 74.2857% (minimum 75%, Missing); hypothalamus: 73.9336% (minimum 75%, Missing); kidney: 68.1223% (minimum 75%, Missing); liver: 65.8228% (minimum 75%, Missing); lung: 70.9091% (minimum 75%, Missing); pancreas: 60.2317% (minimum 75%, Missing); parathyroid gland: 67.8261% (minimum 70%, Missing); pituitary gland: 64.7303% (minimum 75%, Missing); retina: 67.8261% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); smooth muscle: 61.9048% (minimum 75%, Missing); spinal cord: 73.2394% (minimum 75%, Missing); stomach: 66.9528% (minimum 70%, Missing); thyroid gland: 58.4270% (minimum 65%, Missing); urinary bladder: 66.1017% (minimum 70%, Missing)",-0.0722222,-0.0389831,-0.147683,0,80,unavailable,10.3,8,11.4,"adipose tissue: 11.4 nTPM (manageable, limit 5); thyroid gland: 11.1 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); smooth muscle: 9.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 3); salivary gland: 7.8 nTPM (protected, limit 3); stomach: 7.7 nTPM (protected, limit 3); retina: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.4 nTPM (protected, limit 3); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 3); lung: 6.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); spinal cord: 5.7 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); midbrain: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); tongue: 4.1 nTPM (protected, limit 3); skeletal muscle: 3.9 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 3); basal ganglia: 3.7 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,UGGT2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000102780,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 47.5524% (minimum 75%, Missing); cerebellum: 53.5433% (minimum 75%, Missing); colon: 65.3846% (minimum 70%, Missing); esophagus: 62.9630% (minimum 70%, Missing); heart muscle: 70.1031% (minimum 75%, Missing); kidney: 68.0000% (minimum 75%, Missing); lung: 47.5524% (minimum 75%, Missing); pituitary gland: 73.1183% (minimum 75%, Missing); rectum: 68.0000% (minimum 70%, Missing); retina: 73.1183% (minimum 75%, Missing); small intestine: 72.3404% (minimum 75%, Missing); smooth muscle: 63.5514% (minimum 75%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",0.00384615,-0.128571,-0.274476,0,2,partial,7.5,5.1,3.6,"basal ganglia: 7.5 nTPM (vital, limit 1); lung: 7.5 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 3); esophagus: 4 nTPM (protected, limit 3); smooth muscle: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); kidney: 3.2 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 3); heart muscle: 2.9 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DGKH,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000102781,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 67.7852% (minimum 75%, Missing); heart muscle: 53.8667% (minimum 75%, Missing); retina: 72.6619% (minimum 75%, Missing); smooth muscle: 58.3815% (minimum 75%, Missing); spinal cord: 73.7226% (minimum 75%, Missing)",0.0417808,0.00629371,-0.211333,0,80,unavailable,17.3,8.4,9,"heart muscle: 17.3 nTPM (vital, limit 1); smooth muscle: 14.4 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); thymus: 9 nTPM (manageable, limit 5); adipose tissue: 8.4 nTPM (manageable, limit 5); colon: 8.4 nTPM (protected, limit 3); retina: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 3); bone marrow: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 3); hypothalamus: 6 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 3); midbrain: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); lung: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 3); kidney: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KATNAL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000102924,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 6.5845% (minimum 75%, Missing); hypothalamus: 45.3216% (minimum 75%, Missing); midbrain: 63.6550% (minimum 75%, Missing)",0.0811321,0.248012,-0.684155,0,80,unavailable,439.8,1.7,11.4,"cerebellum: 439.8 nTPM (vital, limit 1); hypothalamus: 37.4 nTPM (vital, limit 1); midbrain: 17.7 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (manageable, limit 5); spinal cord: 9.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); pituitary gland: 4.1 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CBLN1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000102970,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.3333% (minimum 65%, Uncertain); colon: 57.5758% (minimum 70%, Missing); esophagus: 38.7755% (minimum 70%, Uncertain); heart muscle: 59.3750% (minimum 75%, Missing); lung: 30.1587% (minimum 75%, Missing); lymph node: 18.8119% (minimum 70%, Missing); rectum: 42.2222% (minimum 70%, Missing); salivary gland: 43.1818% (minimum 70%, Missing); skin: 44.1860% (minimum 65%, Missing); small intestine: 34.5455% (minimum 75%, Missing); smooth muscle: 43.1818% (minimum 75%, Missing); thymus: 8.4821% (minimum 65%, Missing); urinary bladder: 36.5385% (minimum 70%, Missing)",-0.565179,-0.511881,-0.448413,0,3,partial,4.4,8.2,20.5,"thymus: 20.5 nTPM (manageable, limit 5); lymph node: 8.2 nTPM (protected, limit 3); lung: 4.4 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); smooth muscle: 2.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCL17,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000103021,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.27638,0.120652,0.014557,0,80,unavailable,9.3,6.6,2.4,"choroid plexus: 9.3 nTPM (vital, limit 1); retina: 9.1 nTPM (vital, limit 1); basal ganglia: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 3); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP263,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000103023,True,compatible,,True,True,True,,0.35,0.3,0.247519,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRSS54,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000103343,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6872% (minimum 65%, Missing); adrenal gland: 62.6374% (minimum 75%, Missing); amygdala: 65.1429% (minimum 75%, Missing); basal ganglia: 63.3333% (minimum 75%, Missing); bone marrow: 74.0260% (minimum 75%, Missing); cerebellum: 56.4356% (minimum 75%, Missing); cerebral cortex: 60.9626% (minimum 75%, Missing); choroid plexus: 65.5172% (minimum 75%, Missing); colon: 53.0233% (minimum 70%, Missing); duodenum: 65.5172% (minimum 70%, Approved); esophagus: 65.8960% (minimum 70%, Missing); heart muscle: 54.0284% (minimum 75%, Missing); hippocampal formation: 63.3333% (minimum 75%, Missing); hypothalamus: 62.6374% (minimum 75%, Missing); kidney: 64.0449% (minimum 75%, Missing); liver: 63.6872% (minimum 75%, Missing); lung: 68.6747% (minimum 75%, Missing); lymph node: 58.7629% (minimum 65%, Approved); midbrain: 63.3333% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 45.6000% (minimum 70%, Missing); pituitary gland: 55.8824% (minimum 75%, Missing); rectum: 62.2951% (minimum 70%, Missing); retina: 54.2857% (minimum 75%, Missing); salivary gland: 59.6859% (minimum 70%, Missing); skeletal muscle: 54.5455% (minimum 75%, Missing); skin: 61.2903% (minimum 65%, Missing); small intestine: 64.4068% (minimum 70%, Approved); smooth muscle: 53.2710% (minimum 75%, Missing); spinal cord: 58.4615% (minimum 75%, Missing); stomach: 63.3333% (minimum 70%, Missing); thymus: 55.0725% (minimum 65%, Missing); thyroid gland: 60.9626% (minimum 65%, Missing); tongue: 52.7778% (minimum 70%, Missing); urinary bladder: 56.7164% (minimum 70%, Missing)",-0.0992754,-0.244,-0.21729,0,2,partial,10,13.6,9.3,"parathyroid gland: 13.6 nTPM (protected, limit 3); tongue: 10.2 nTPM (protected, limit 3); colon: 10.1 nTPM (protected, limit 3); smooth muscle: 10 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); retina: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); thymus: 9.3 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); cerebellum: 8.8 nTPM (vital, limit 1); urinary bladder: 8.7 nTPM (protected, limit 3); spinal cord: 8.1 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 4); salivary gland: 7.7 nTPM (protected, limit 3); thyroid gland: 7.3 nTPM (manageable, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); skin: 7.2 nTPM (manageable, limit 5); rectum: 6.9 nTPM (protected, limit 3); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 3); basal ganglia: 6.6 nTPM (vital, limit 1); liver: 6.5 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (manageable, limit 5); kidney: 6.4 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 2); amygdala: 6.1 nTPM (vital, limit 1); duodenum: 6 nTPM (vital, limit 2); choroid plexus: 6 nTPM (vital, limit 1); esophagus: 5.9 nTPM (protected, limit 3); pancreas: 5.7 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF174,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000103546,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 39.5210% (minimum 60%, Enhanced)",0.0945946,0.3,-0.20479,0,4,partial,10.1,1.1,4.5,"adrenal gland: 10.1 nTPM (vital, limit 6)",cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebral cortex / neuronal projections: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),77,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC6A2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,"Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016",False,False,False,False,False,unchanged,
ENSG00000103599,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 70.0000% (minimum 75%, Missing)",0.0917219,0.0567568,-0.05,0,80,unavailable,4.8,3.6,3.9,"retina: 4.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IQCH,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000103642,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 46.5217% (minimum 75%, Missing); basal ganglia: 72.5424% (minimum 75%, Missing); bone marrow: 27.4711% (minimum 75%, Missing); choroid plexus: 64.0719% (minimum 75%, Missing); colon: 54.4529% (minimum 70%, Missing); duodenum: 52.9703% (minimum 75%, Missing); esophagus: 59.7765% (minimum 70%, Missing); heart muscle: 49.8834% (minimum 75%, Missing); kidney: 48.5261% (minimum 75%, Missing); liver: 34.2400% (minimum 75%, Missing); lung: 53.7688% (minimum 75%, Missing); lymph node: 52.5799% (minimum 70%, Missing); midbrain: 74.3056% (minimum 75%, Missing); pancreas: 67.5079% (minimum 75%, Missing); parathyroid gland: 69.2557% (minimum 70%, Missing); rectum: 58.1522% (minimum 70%, Missing); salivary gland: 69.0323% (minimum 70%, Missing); skeletal muscle: 31.0595% (minimum 75%, Missing); skin: 64.8485% (minimum 65%, Missing); small intestine: 56.6138% (minimum 75%, Missing); spleen: 54.5918% (minimum 65%, Missing); stomach: 63.3136% (minimum 70%, Missing); tongue: 38.0107% (minimum 70%, Missing); urinary bladder: 52.9703% (minimum 70%, Missing)",-0.104082,-0.319893,-0.475289,0,9,partial,56.5,34.9,17.8,"bone marrow: 56.5 nTPM (vital, limit 1); skeletal muscle: 47.5 nTPM (vital, limit 1); liver: 41.1 nTPM (vital, limit 1); tongue: 34.9 nTPM (protected, limit 3); adrenal gland: 24.6 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); heart muscle: 21.5 nTPM (vital, limit 1); lymph node: 19.3 nTPM (protected, limit 3); urinary bladder: 19 nTPM (protected, limit 3); duodenum: 19 nTPM (vital, limit 1); lung: 18.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 3); spleen: 17.8 nTPM (manageable, limit 5); adipose tissue: 16.7 nTPM (manageable, limit 15); small intestine: 16.4 nTPM (vital, limit 1); rectum: 15.4 nTPM (protected, limit 3); esophagus: 14.4 nTPM (protected, limit 3); stomach: 12.4 nTPM (protected, limit 3); choroid plexus: 12 nTPM (vital, limit 1); skin: 11.6 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 3); parathyroid gland: 9.5 nTPM (protected, limit 3); thyroid gland: 9 nTPM (manageable, limit 5); thymus: 8.9 nTPM (manageable, limit 5); smooth muscle: 8.7 nTPM (vital, limit 3); basal ganglia: 8.1 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 6.5 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LACTB,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000103723,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.2524% (minimum 75%, Missing); amygdala: 44.4444% (minimum 75%, Missing); basal ganglia: 36.8098% (minimum 75%, Missing); cerebellum: 11.8577% (minimum 75%, Missing); cerebral cortex: 17.8571% (minimum 75%, Missing); choroid plexus: 56.0748% (minimum 75%, Missing); hippocampal formation: 40.8163% (minimum 75%, Missing); hypothalamus: 31.9149% (minimum 75%, Missing); midbrain: 50.8475% (minimum 75%, Missing); parathyroid gland: 32.7869% (minimum 70%, Missing); pituitary gland: 24.6914% (minimum 75%, Missing); retina: 15.8730% (minimum 75%, Missing); spinal cord: 56.6038% (minimum 75%, Missing)",0.109494,-0.372131,-0.631423,0,12,partial,44.6,12.3,1.9,"cerebellum: 44.6 nTPM (vital, limit 1); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 27.6 nTPM (vital, limit 1); pituitary gland: 18.3 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 3); basal ganglia: 10.3 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / enterocytes: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AP3B2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000103995,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 37.2093% (minimum 70%, Approved); thymus: 63.5762% (minimum 65%, Missing)",-0.0142384,0.0456522,-0.327907,0,3,partial,16.2,4.2,5.5,"bone marrow: 16.2 nTPM (vital, limit 2); thymus: 5.5 nTPM (manageable, limit 5); lymph node: 4.2 nTPM (protected, limit 4); pancreas: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 2); kidney: 2.1 nTPM (vital, limit 2); lung: 2.1 nTPM (vital, limit 2); retina: 1.8 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CEP152,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000104147,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0475945,0.233784,0.0655738,0,3,partial,10.2,5.6,8.8,"bone marrow: 10.2 nTPM (vital, limit 6); skeletal muscle: 9.9 nTPM (vital, limit 6); thymus: 8.8 nTPM (manageable, limit 5)",pancreas / exocrine glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OIP5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000104218,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 71.4286% (minimum 75%, Missing); cerebellum: 64.1026% (minimum 75%, Missing); hippocampal formation: 72.2543% (minimum 75%, Missing); hypothalamus: 71.4286% (minimum 75%, Missing); kidney: 70.2247% (minimum 75%, Missing); liver: 70.2247% (minimum 75%, Missing); lung: 69.0608% (minimum 75%, Missing); pancreas: 68.3060% (minimum 75%, Missing); skeletal muscle: 48.8281% (minimum 75%, Missing); spinal cord: 74.4048% (minimum 75%, Missing)",0.0852941,0.048503,-0.261719,0,80,unavailable,13.1,4.2,4.5,"skeletal muscle: 13.1 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1); pancreas: 5.8 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 3); parathyroid gland: 4.1 nTPM (protected, limit 3); cerebral cortex: 4 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); amygdala: 4 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 3); small intestine: 3.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 3); esophagus: 3.3 nTPM (protected, limit 3); pituitary gland: 3.2 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CSPP1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000104432,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 68.6567% (minimum 70%, Approved); colon: 48.4211% (minimum 65%, Approved); duodenum: 41.4414% (minimum 70%, Approved); esophagus: 57.5000% (minimum 65%, Approved); liver: 53.4884% (minimum 70%, Approved); lung: 58.9744% (minimum 70%, Approved); lymph node: 35.1145% (minimum 65%, Approved); rectum: 51.6854% (minimum 65%, Approved); skin: 35.1145% (minimum 60%, Approved); small intestine: 35.1145% (minimum 70%, Approved); spleen: 57.5000% (minimum 60%, Approved); stomach: 55.4217% (minimum 65%, Approved); urinary bladder: 63.0137% (minimum 65%, Approved)",-0.248855,-0.298855,-0.348855,0,6,partial,8.5,8.5,8.5,"lymph node: 8.5 nTPM (protected, limit 4); small intestine: 8.5 nTPM (vital, limit 2); duodenum: 6.5 nTPM (vital, limit 2); colon: 4.9 nTPM (protected, limit 4); rectum: 4.3 nTPM (protected, limit 4); liver: 4 nTPM (vital, limit 2); lung: 3.2 nTPM (vital, limit 2); bone marrow: 2.1 nTPM (vital, limit 2)",bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved); nasopharynx / goblet cells: High (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IL7,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000104450,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 65.3979% (minimum 75%, Missing); choroid plexus: 64.0678% (minimum 75%, Missing); rectum: 51.6393% (minimum 70%, Missing)",0.210526,-0.183607,-0.109322,0,5,partial,10.6,17.7,7.7,"rectum: 17.7 nTPM (protected, limit 3); colon: 12.4 nTPM (protected, limit 12); choroid plexus: 10.6 nTPM (vital, limit 1); bone marrow: 10 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPAG1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000104497,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.8326% (minimum 65%, Missing); adrenal gland: 74.0933% (minimum 75%, Missing); bone marrow: 57.8947% (minimum 75%, Missing); cerebral cortex: 74.0933% (minimum 75%, Missing); duodenum: 69.7561% (minimum 75%, Missing); esophagus: 46.8852% (minimum 70%, Missing); heart muscle: 64.7059% (minimum 75%, Missing); hypothalamus: 71.5000% (minimum 75%, Missing); kidney: 69.0821% (minimum 75%, Missing); liver: 72.9592% (minimum 75%, Missing); lung: 68.7500% (minimum 75%, Missing); midbrain: 69.0821% (minimum 75%, Missing); parathyroid gland: 62.4454% (minimum 70%, Missing); rectum: 69.4175% (minimum 70%, Missing); skin: 56.7460% (minimum 65%, Missing); small intestine: 72.2222% (minimum 75%, Missing); smooth muscle: 55.6420% (minimum 75%, Missing); spinal cord: 68.7500% (minimum 75%, Missing); spleen: 55.0000% (minimum 65%, Missing); stomach: 62.1739% (minimum 70%, Missing); thymus: 60.8511% (minimum 65%, Missing); thyroid gland: 62.9956% (minimum 65%, Missing); tongue: 61.6379% (minimum 70%, Missing); urinary bladder: 67.7725% (minimum 70%, Missing)",-0.1,-0.231148,-0.19358,0,5,partial,11.4,16.2,11.7,"esophagus: 16.2 nTPM (protected, limit 3); spleen: 11.7 nTPM (manageable, limit 5); smooth muscle: 11.4 nTPM (vital, limit 1); skin: 10.9 nTPM (manageable, limit 5); bone marrow: 10.4 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); tongue: 8.9 nTPM (protected, limit 3); stomach: 8.7 nTPM (protected, limit 3); parathyroid gland: 8.6 nTPM (protected, limit 3); thyroid gland: 8.4 nTPM (manageable, limit 5); heart muscle: 7.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 3); spinal cord: 6.5 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 3); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 3); hypothalamus: 5.7 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); liver: 5.3 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); lymph node: 4.9 nTPM (protected, limit 3); retina: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SNX16,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000104499,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 1.7314% (minimum 75%, Missing)",0.35,0.3,-0.732686,0,80,unavailable,187.3,0,0,"adrenal gland: 187.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GML,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000104755,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ADAM2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000104804,True,compatible,,True,True,True,,0.321246,0.290228,0.227492,0,80,unavailable,0.7,0.3,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TULP2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000104818,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 71.4286% (minimum 75%, Missing)",0.332353,0.282353,-0.0357143,0,1,partial,0.6,0.2,0.2,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CGB2,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000104827,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.076087,0,2,partial,2.2,0.2,0.1,"pituitary gland: 2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CGB3,current_adaptive,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000104835,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 41.4634% (minimum 75%, Missing); amygdala: 60.4061% (minimum 75%, Missing); basal ganglia: 58.6207% (minimum 75%, Missing); bone marrow: 56.3981% (minimum 75%, Missing); cerebellum: 52.1930% (minimum 75%, Missing); cerebral cortex: 48.3740% (minimum 75%, Missing); choroid plexus: 60.7143% (minimum 75%, Missing); colon: 54.8387% (minimum 70%, Missing); duodenum: 56.9378% (minimum 75%, Missing); esophagus: 46.1240% (minimum 70%, Missing); heart muscle: 49.7908% (minimum 75%, Missing); hippocampal formation: 58.9109% (minimum 75%, Missing); hypothalamus: 58.6207% (minimum 75%, Missing); kidney: 45.5939% (minimum 75%, Missing); liver: 39.5349% (minimum 75%, Missing); lung: 65.0273% (minimum 75%, Missing); lymph node: 55.3488% (minimum 70%, Missing); midbrain: 62.3037% (minimum 75%, Missing); pancreas: 43.4307% (minimum 75%, Missing); parathyroid gland: 61.3402% (minimum 70%, Missing); pituitary gland: 50.6383% (minimum 75%, Missing); salivary gland: 51.9651% (minimum 70%, Missing); skeletal muscle: 42.8058% (minimum 75%, Missing); skin: 49.7908% (minimum 65%, Missing); small intestine: 54.5872% (minimum 75%, Missing); smooth muscle: 70.4142% (minimum 75%, Missing); spinal cord: 61.9792% (minimum 75%, Missing); spleen: 50.4237% (minimum 65%, Missing); stomach: 50.6383% (minimum 70%, Missing); thymus: 61.9792% (minimum 65%, Missing); thyroid gland: 46.1240% (minimum 65%, Missing); tongue: 51.7391% (minimum 70%, Missing); urinary bladder: 56.6667% (minimum 70%, Missing)",-0.18876,-0.23876,-0.354651,0,2,partial,18.2,13.9,13.9,"liver: 18.2 nTPM (vital, limit 1); adrenal gland: 16.8 nTPM (vital, limit 1); skeletal muscle: 15.9 nTPM (vital, limit 1); pancreas: 15.5 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); esophagus: 13.9 nTPM (protected, limit 3); thyroid gland: 13.9 nTPM (manageable, limit 5); cerebral cortex: 12.7 nTPM (vital, limit 1); skin: 12 nTPM (manageable, limit 5); heart muscle: 12 nTPM (vital, limit 1); spleen: 11.7 nTPM (manageable, limit 5); pituitary gland: 11.6 nTPM (vital, limit 1); stomach: 11.6 nTPM (protected, limit 3); tongue: 11.1 nTPM (protected, limit 3); salivary gland: 11 nTPM (protected, limit 3); cerebellum: 10.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 3); lymph node: 9.6 nTPM (protected, limit 3); bone marrow: 9.2 nTPM (vital, limit 1); urinary bladder: 9.1 nTPM (protected, limit 3); duodenum: 9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); basal ganglia: 8.4 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 3); spinal cord: 7.3 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); midbrain: 7.2 nTPM (vital, limit 1); lung: 6.4 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 3); smooth muscle: 5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SARS2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000104880,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 51.2658% (minimum 75%, Missing); amygdala: 59.7786% (minimum 75%, Missing); basal ganglia: 57.4468% (minimum 75%, Missing); bone marrow: 37.6744% (minimum 75%, Missing); cerebellum: 52.5974% (minimum 70%, Approved); cerebral cortex: 51.4286% (minimum 70%, Approved); colon: 42.9708% (minimum 70%, Missing); duodenum: 55.4795% (minimum 75%, Missing); esophagus: 45.6338% (minimum 70%, Missing); heart muscle: 70.1299% (minimum 75%, Missing); hippocampal formation: 56.0554% (minimum 75%, Missing); hypothalamus: 61.5970% (minimum 75%, Missing); kidney: 40.9091% (minimum 75%, Missing); liver: 56.0554% (minimum 70%, Approved); lung: 53.4653% (minimum 75%, Missing); lymph node: 35.8407% (minimum 70%, Missing); midbrain: 58.6957% (minimum 75%, Missing); pancreas: 44.2623% (minimum 75%, Missing); parathyroid gland: 60.0000% (minimum 65%, Approved); pituitary gland: 51.2658% (minimum 75%, Missing); rectum: 68.3544% (minimum 70%, Missing); salivary gland: 60.4478% (minimum 70%, Missing); skin: 54.9153% (minimum 65%, Missing); small intestine: 34.8387% (minimum 75%, Missing); smooth muscle: 54.7297% (minimum 70%, Approved); spinal cord: 57.8571% (minimum 75%, Missing); spleen: 31.5789% (minimum 65%, Missing); stomach: 42.5197% (minimum 70%, Missing); thymus: 33.4711% (minimum 65%, Missing); thyroid gland: 60.6742% (minimum 65%, Missing); urinary bladder: 54.5455% (minimum 70%, Missing)",-0.334211,-0.341593,-0.401613,0,5,partial,30.3,29,35.1,"spleen: 35.1 nTPM (manageable, limit 5); thymus: 32.2 nTPM (manageable, limit 5); small intestine: 30.3 nTPM (vital, limit 1); lymph node: 29 nTPM (protected, limit 3); bone marrow: 26.8 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); stomach: 21.9 nTPM (protected, limit 3); colon: 21.5 nTPM (protected, limit 3); pancreas: 20.4 nTPM (vital, limit 1); esophagus: 19.3 nTPM (protected, limit 3); adrenal gland: 15.4 nTPM (vital, limit 1); pituitary gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 2); cerebellum: 14.6 nTPM (vital, limit 2); lung: 14.1 nTPM (vital, limit 1); urinary bladder: 13.5 nTPM (protected, limit 3); smooth muscle: 13.4 nTPM (vital, limit 2); skin: 13.3 nTPM (manageable, limit 5); duodenum: 13 nTPM (vital, limit 1); hippocampal formation: 12.7 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 2); basal ganglia: 12 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 4); salivary gland: 10.6 nTPM (protected, limit 3); thyroid gland: 10.5 nTPM (manageable, limit 5); hypothalamus: 10.1 nTPM (vital, limit 1); rectum: 7.5 nTPM (protected, limit 3); heart muscle: 6.9 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / Langerhans: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ARHGEF18,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000104901,True,compatible,,True,True,True,,0.35,0.299106,0.249106,0,1,partial,0.9,0.9,0.7,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DKKL1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000104941,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,2.7,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RSPH6A,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000104951,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.219565,0.0428571,0.0969055,0,11,partial,4.7,9,3.9,"lymph node: 9 nTPM (protected, limit 3); kidney: 4.7 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / basal cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); bronchus / goblet cells: Medium (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in corneal layer: High (Enhanced); skin 1 / cells in granular layer: High (Enhanced); skin 1 / cells in spinous layer: High (Enhanced); skin 1 / eccrine glands: Low (Enhanced); skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 1 / langerhans cells: High (Enhanced); skin 1 / lymphocytes: High (Enhanced); skin 1 / sebaceous glands: High (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced); skin 2 / cells in granular layer: High (Enhanced); skin 2 / cells in spinous layer: High (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); skin 2 / langerhans cells: High (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced),88,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in corneal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / sebaceous glands; skin 2 / cells in basal layer; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IL4I1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000105011,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"thymus: 57.9143% (minimum 65%, Missing)",-0.0708566,0.0182448,0.0928184,0,6,partial,11.5,12.2,22.6,"thymus: 22.6 nTPM (manageable, limit 5); lymph node: 12.2 nTPM (protected, limit 3); bone marrow: 11.5 nTPM (vital, limit 6); rectum: 7.5 nTPM (protected, limit 3); colon: 7.2 nTPM (protected, limit 3); small intestine: 5.8 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ASF1B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000105085,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.240306,0.199485,0.158854,0,8,partial,10.9,5.1,6.2,"bone marrow: 10.9 nTPM (vital, limit 6); skeletal muscle: 6.7 nTPM (vital, limit 6); colon: 3.9 nTPM (protected, limit 3); pituitary gland: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); basal ganglia: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MED26,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000105143,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 55.5102% (minimum 75%, Missing); cerebellum: 18.8496% (minimum 75%, Missing); cerebral cortex: 70.2842% (minimum 75%, Missing); hippocampal formation: 69.3878% (minimum 75%, Missing); hypothalamus: 72.9223% (minimum 75%, Missing)",0.116197,0.292701,-0.561504,0,11,partial,117.1,0.9,8.3,"cerebellum: 117.1 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); hippocampal formation: 12 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); amygdala: 7.7 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / endothelial cells: High (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced),84,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC1A6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000105146,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.252196,0.230041,0.17623,0,80,unavailable,3.6,3.4,4.9,"choroid plexus: 3.6 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AURKC,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000105198,True,compatible,,True,True,True,,0.35,0.290909,0.231982,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LGALS13,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016;da Silva 2017 · testis-biased",False,True,True,True,True,gained,selectivity_revised
ENSG00000105246,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.289434,0.297205,0.216148,0,3,partial,8.1,19.7,33.1,"spleen: 33.1 nTPM (manageable, limit 30); lymph node: 19.7 nTPM (protected, limit 12); thymus: 9.2 nTPM (manageable, limit 5); small intestine: 8.1 nTPM (vital, limit 6); spinal cord: 5 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EBI3,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000105261,True,compatible,,True,True,True,,0.172222,0.273684,0.175,0,80,unavailable,0.3,0.1,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OVOL3,current_adaptive,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,True,True,True,True,gained,selectivity_revised
ENSG00000105270,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 29.6984% (minimum 75%, Missing); basal ganglia: 32.5203% (minimum 75%, Missing); cerebellum: 22.9308% (minimum 75%, Missing); cerebral cortex: 23.0299% (minimum 75%, Missing); choroid plexus: 68.3031% (minimum 75%, Missing); colon: 46.8178% (minimum 70%, Missing); hippocampal formation: 31.6362% (minimum 75%, Missing); hypothalamus: 29.9625% (minimum 75%, Missing); midbrain: 35.1455% (minimum 75%, Missing); pituitary gland: 58.3409% (minimum 75%, Missing); retina: 54.6075% (minimum 75%, Missing); smooth muscle: 63.6183% (minimum 75%, Missing); spinal cord: 41.5584% (minimum 75%, Missing); urinary bladder: 49.2308% (minimum 70%, Missing)",0.152005,-0.231822,-0.520692,0,80,unavailable,215.1,72.7,15.8,"cerebellum: 215.1 nTPM (vital, limit 1); cerebral cortex: 213.9 nTPM (vital, limit 1); amygdala: 151.5 nTPM (vital, limit 1); hypothalamus: 149.6 nTPM (vital, limit 1); hippocampal formation: 138.3 nTPM (vital, limit 1); basal ganglia: 132.8 nTPM (vital, limit 1); midbrain: 118.1 nTPM (vital, limit 1); spinal cord: 90 nTPM (vital, limit 1); colon: 72.7 nTPM (protected, limit 3); urinary bladder: 66 nTPM (protected, limit 3); retina: 53.2 nTPM (vital, limit 1); pituitary gland: 45.7 nTPM (vital, limit 1); smooth muscle: 36.6 nTPM (vital, limit 1); choroid plexus: 29.7 nTPM (vital, limit 1); stomach: 24.8 nTPM (protected, limit 3); small intestine: 20.8 nTPM (vital, limit 1); adipose tissue: 15.8 nTPM (manageable, limit 5); esophagus: 15.7 nTPM (protected, limit 3); adrenal gland: 13.1 nTPM (vital, limit 1); heart muscle: 12.3 nTPM (vital, limit 1); kidney: 11.2 nTPM (vital, limit 1); lung: 9.7 nTPM (vital, limit 1); spleen: 9.7 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); rectum: 8.3 nTPM (protected, limit 3); skin: 7.6 nTPM (manageable, limit 5); lymph node: 6.8 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 3); thyroid gland: 5.4 nTPM (manageable, limit 5); pancreas: 3.5 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 3); skeletal muscle: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CLIP3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000105428,True,compatible,,True,True,True,,0.35,0.3,0.248289,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNRF4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000105467,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.296234,0.23694,0,4,partial,6.1,3.8,0.1,"cerebellum: 6.1 nTPM (vital, limit 6)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SYNGR4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000105479,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 46.6038% (minimum 75%, Missing)",0.341968,0.3,-0.283962,0,6,partial,28.3,0.6,0.5,"choroid plexus: 28.3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 2); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ODAD1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000105492,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.343256,0.271725,0.219897,0,8,partial,4.3,3.7,1.7,"small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",colon / mucosal lymphoid cells: Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SIGLEC6,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000105549,True,compatible,,True,True,True,,0.288636,0.292788,0.230998,0,80,unavailable,0.8,0.3,2.7,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPMAP2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000105647,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 45.6140% (minimum 75%, Missing); amygdala: 40.3883% (minimum 75%, Missing); basal ganglia: 38.4473% (minimum 75%, Missing); bone marrow: 68.4211% (minimum 75%, Missing); cerebellum: 54.3081% (minimum 75%, Missing); cerebral cortex: 34.4371% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); duodenum: 50.9804% (minimum 75%, Missing); esophagus: 45.1193% (minimum 70%, Missing); heart muscle: 62.8399% (minimum 70%, Approved); hippocampal formation: 32.9114% (minimum 75%, Missing); hypothalamus: 61.5385% (minimum 75%, Missing); kidney: 69.1030% (minimum 75%, Missing); liver: 66.8810% (minimum 75%, Missing); lung: 70.2703% (minimum 75%, Missing); midbrain: 69.3333% (minimum 75%, Missing); pancreas: 66.0317% (minimum 75%, Missing); parathyroid gland: 50.8557% (minimum 70%, Missing); pituitary gland: 49.8801% (minimum 75%, Missing); rectum: 69.1030% (minimum 70%, Missing); retina: 73.2394% (minimum 75%, Missing); salivary gland: 58.9235% (minimum 70%, Missing); skeletal muscle: 63.4146% (minimum 70%, Approved); skin: 44.7312% (minimum 65%, Missing); small intestine: 56.2162% (minimum 75%, Missing); smooth muscle: 68.8742% (minimum 70%, Approved); spinal cord: 70.7483% (minimum 75%, Missing); stomach: 58.5915% (minimum 70%, Missing); thymus: 64.7975% (minimum 65%, Missing); tongue: 68.6469% (minimum 70%, Missing); urinary bladder: 58.4270% (minimum 70%, Missing)",-0.202688,-0.248807,-0.420886,0,1,partial,42.4,25.3,25.7,"hippocampal formation: 42.4 nTPM (vital, limit 1); cerebral cortex: 39.6 nTPM (vital, limit 1); basal ganglia: 33.3 nTPM (vital, limit 1); amygdala: 30.7 nTPM (vital, limit 1); skin: 25.7 nTPM (manageable, limit 5); esophagus: 25.3 nTPM (protected, limit 3); adrenal gland: 24.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 3); duodenum: 20 nTPM (vital, limit 1); cerebellum: 17.5 nTPM (vital, limit 1); small intestine: 16.2 nTPM (vital, limit 1); urinary bladder: 14.8 nTPM (protected, limit 3); stomach: 14.7 nTPM (protected, limit 3); salivary gland: 14.5 nTPM (protected, limit 3); hypothalamus: 13 nTPM (vital, limit 1); colon: 13 nTPM (protected, limit 3); heart muscle: 12.3 nTPM (vital, limit 2); skeletal muscle: 12 nTPM (vital, limit 2); thymus: 11.3 nTPM (manageable, limit 5); pancreas: 10.7 nTPM (vital, limit 1); liver: 10.3 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (manageable, limit 5); bone marrow: 9.6 nTPM (vital, limit 1); tongue: 9.5 nTPM (protected, limit 3); smooth muscle: 9.4 nTPM (vital, limit 2); rectum: 9.3 nTPM (protected, limit 3); kidney: 9.3 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); retina: 7.6 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); choroid plexus: 5.8 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PIK3R2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000105672,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.270398,0.206863,0.139423,0,80,unavailable,2.3,1.9,1.6,"pancreas: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ETV2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000105679,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.237204,0,3,partial,5,6.3,13.5,"retina: 3.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GAPDHS,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000105737,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 65.4397% (minimum 75%, Missing); basal ganglia: 60.8365% (minimum 75%, Missing); cerebellum: 49.4590% (minimum 75%, Missing); cerebral cortex: 53.9629% (minimum 75%, Missing); colon: 66.8058% (minimum 70%, Missing); hippocampal formation: 61.5385% (minimum 75%, Missing); hypothalamus: 67.5105% (minimum 75%, Missing); parathyroid gland: 69.8690% (minimum 70%, Missing); pituitary gland: 64.2570% (minimum 75%, Missing); retina: 72.8929% (minimum 75%, Missing)",0.094186,-0.0319415,-0.25541,0,80,unavailable,32.7,15.9,11,"cerebellum: 32.7 nTPM (vital, limit 1); cerebral cortex: 27.3 nTPM (vital, limit 1); basal ganglia: 20.6 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); pituitary gland: 17.8 nTPM (vital, limit 1); amygdala: 16.9 nTPM (vital, limit 1); colon: 15.9 nTPM (protected, limit 3); hypothalamus: 15.4 nTPM (vital, limit 1); parathyroid gland: 13.8 nTPM (protected, limit 3); retina: 11.9 nTPM (vital, limit 1); thyroid gland: 11 nTPM (manageable, limit 5); midbrain: 8.9 nTPM (vital, limit 1); choroid plexus: 7 nTPM (vital, limit 1); kidney: 6.8 nTPM (vital, limit 1); stomach: 5.1 nTPM (protected, limit 3); smooth muscle: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); heart muscle: 4.8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GRIK5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000105750,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.0000% (minimum 75%, Missing); bone marrow: 70.0000% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); pancreas: 58.6387% (minimum 75%, Missing); stomach: 67.4699% (minimum 70%, Missing); thyroid gland: 59.8930% (minimum 65%, Missing)",-0.0510695,-0.0333333,-0.163613,0,5,partial,7.9,5.6,7.5,"pancreas: 7.9 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 3); stomach: 5.4 nTPM (protected, limit 3); thymus: 5.2 nTPM (manageable, limit 5); adrenal gland: 4.8 nTPM (vital, limit 1); bone marrow: 4.8 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF85,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000105793,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.0681% (minimum 60%, Approved); adrenal gland: 60.8939% (minimum 75%, Missing); basal ganglia: 74.6575% (minimum 75%, Missing); bone marrow: 63.0058% (minimum 70%, Approved); cerebellum: 67.7019% (minimum 75%, Missing); cerebral cortex: 60.2210% (minimum 75%, Missing); choroid plexus: 73.1544% (minimum 75%, Missing); colon: 56.1856% (minimum 70%, Missing); duodenum: 56.1856% (minimum 75%, Missing); esophagus: 57.6720% (minimum 70%, Missing); heart muscle: 52.9126% (minimum 70%, Approved); hippocampal formation: 73.6486% (minimum 75%, Missing); hypothalamus: 72.1854% (minimum 75%, Missing); kidney: 47.3913% (minimum 75%, Missing); liver: 37.5862% (minimum 70%, Approved); lung: 66.0606% (minimum 75%, Missing); lymph node: 50.6977% (minimum 70%, Missing); midbrain: 71.7105% (minimum 75%, Missing); pancreas: 59.5628% (minimum 75%, Missing); parathyroid gland: 58.2888% (minimum 70%, Missing); pituitary gland: 71.2418% (minimum 75%, Missing); rectum: 53.9604% (minimum 70%, Missing); retina: 60.8939% (minimum 75%, Missing); salivary gland: 64.8810% (minimum 70%, Missing); skeletal muscle: 48.0176% (minimum 75%, Missing); skin: 62.2857% (minimum 65%, Missing); small intestine: 61.2360% (minimum 75%, Missing); smooth muscle: 61.2360% (minimum 75%, Missing); spinal cord: 70.7792% (minimum 75%, Missing); spleen: 60.2210% (minimum 65%, Missing); stomach: 51.1737% (minimum 70%, Missing); thymus: 46.7811% (minimum 65%, Missing); thyroid gland: 53.4314% (minimum 65%, Missing); tongue: 52.9126% (minimum 70%, Missing); urinary bladder: 54.2289% (minimum 70%, Missing)",-0.182189,-0.193023,-0.324138,0,8,partial,18.1,10.6,12.4,"liver: 18.1 nTPM (vital, limit 2); thymus: 12.4 nTPM (manageable, limit 5); kidney: 12.1 nTPM (vital, limit 1); skeletal muscle: 11.8 nTPM (vital, limit 1); lymph node: 10.6 nTPM (protected, limit 3); stomach: 10.4 nTPM (protected, limit 3); tongue: 9.7 nTPM (protected, limit 3); heart muscle: 9.7 nTPM (vital, limit 2); thyroid gland: 9.5 nTPM (manageable, limit 5); rectum: 9.3 nTPM (protected, limit 3); urinary bladder: 9.2 nTPM (protected, limit 3); colon: 8.5 nTPM (protected, limit 3); duodenum: 8.5 nTPM (vital, limit 1); esophagus: 8 nTPM (protected, limit 3); parathyroid gland: 7.8 nTPM (protected, limit 3); pancreas: 7.4 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); cerebral cortex: 7.2 nTPM (vital, limit 1); retina: 7 nTPM (vital, limit 1); adrenal gland: 7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); skin: 6.6 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 2); salivary gland: 5.9 nTPM (protected, limit 3); lung: 5.6 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); pituitary gland: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GTPBP10,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000105825,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342814,0.298598,0.198658,0,4,partial,74.1,25.6,49.6,"pancreas: 74.1 nTPM (vital, limit 6); retina: 50.1 nTPM (vital, limit 1); adipose tissue: 49.6 nTPM (manageable, limit 30); adrenal gland: 27.4 nTPM (vital, limit 6); urinary bladder: 25.6 nTPM (protected, limit 12); liver: 20.6 nTPM (vital, limit 6); kidney: 19.8 nTPM (vital, limit 6); lung: 10.9 nTPM (vital, limit 6); pituitary gland: 9.4 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 6); heart muscle: 7.5 nTPM (vital, limit 6); thymus: 6.7 nTPM (manageable, limit 5); hypothalamus: 4.3 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TFPI2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000105851,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 73.5294% (minimum 75%, Missing); bone marrow: 10.3950% (minimum 75%, Missing); cerebral cortex: 73.5294% (minimum 75%, Missing); colon: 55.5556% (minimum 70%, Missing); duodenum: 55.5556% (minimum 75%, Missing); liver: 72.4638% (minimum 75%, Missing); lung: 51.5464% (minimum 60%, Enhanced); lymph node: 21.2766% (minimum 70%, Missing); rectum: 57.4713% (minimum 70%, Missing); small intestine: 54.3478% (minimum 75%, Missing); spleen: 31.8471% (minimum 65%, Missing); stomach: 56.8182% (minimum 70%, Missing); thymus: 23.8095% (minimum 65%, Missing); urinary bladder: 54.3478% (minimum 70%, Missing)",-0.411905,-0.487234,-0.64605,0,3,partial,43.1,18.5,16,"bone marrow: 43.1 nTPM (vital, limit 1); lymph node: 18.5 nTPM (protected, limit 3); thymus: 16 nTPM (manageable, limit 5); spleen: 10.7 nTPM (manageable, limit 5); small intestine: 4.2 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 3); colon: 4 nTPM (protected, limit 3); duodenum: 4 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); rectum: 3.7 nTPM (protected, limit 3); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PIK3CG,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000105877,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 42.1488% (minimum 75%, Missing); parathyroid gland: 6.8919% (minimum 65%, Approved)",0.236066,-0.581081,-0.328512,0,3,partial,7,68.9,1,"parathyroid gland: 68.9 nTPM (protected, limit 4); choroid plexus: 7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,gallbladder; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAH11,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000105879,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.4789% (minimum 75%, Missing); bone marrow: 36.9091% (minimum 75%, Missing); cerebellum: 68.8136% (minimum 75%, Missing); cerebral cortex: 61.8902% (minimum 75%, Missing); colon: 64.8562% (minimum 70%, Missing); duodenum: 68.5811% (minimum 75%, Missing); esophagus: 66.7763% (minimum 70%, Missing); heart muscle: 67.2185% (minimum 75%, Missing); kidney: 68.3502% (minimum 75%, Missing); liver: 66.3399% (minimum 75%, Missing); lung: 69.0476% (minimum 75%, Missing); lymph node: 58.0000% (minimum 70%, Missing); pancreas: 66.9967% (minimum 75%, Missing); parathyroid gland: 62.2699% (minimum 70%, Missing); rectum: 68.1208% (minimum 70%, Missing); retina: 59.3567% (minimum 75%, Missing); skeletal muscle: 41.0101% (minimum 75%, Missing); small intestine: 67.2185% (minimum 75%, Missing); smooth muscle: 64.0379% (minimum 75%, Missing); spinal cord: 73.2852% (minimum 75%, Missing); spleen: 60.5970% (minimum 65%, Missing); thymus: 53.0026% (minimum 65%, Missing); thyroid gland: 61.3293% (minimum 65%, Missing); tongue: 52.8646% (minimum 70%, Missing); urinary bladder: 65.6958% (minimum 70%, Missing)",-0.119974,-0.171354,-0.380909,0,3,partial,34.7,18.1,18,"bone marrow: 34.7 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 3); thymus: 18 nTPM (manageable, limit 5); lymph node: 14.7 nTPM (protected, limit 3); retina: 13.9 nTPM (vital, limit 1); spleen: 13.2 nTPM (manageable, limit 5); thyroid gland: 12.8 nTPM (manageable, limit 5); cerebral cortex: 12.5 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 3); smooth muscle: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 3); urinary bladder: 10.6 nTPM (protected, limit 3); liver: 10.3 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); adipose tissue: 10.3 nTPM (manageable, limit 5); esophagus: 10.1 nTPM (protected, limit 3); pancreas: 10 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 3); kidney: 9.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 3); salivary gland: 8.4 nTPM (protected, limit 3); adrenal gland: 8.1 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / endothelial cells: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CBLL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000105889,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 59.4595% (minimum 75%, Missing); basal ganglia: 48.8889% (minimum 75%, Missing); cerebral cortex: 55.0000% (minimum 75%, Missing); choroid plexus: 28.5714% (minimum 75%, Missing); hippocampal formation: 51.1628% (minimum 75%, Missing); hypothalamus: 64.7059% (minimum 75%, Missing); lymph node: 57.8947% (minimum 70%, Missing); midbrain: 46.8085% (minimum 75%, Missing); skeletal muscle: 64.7059% (minimum 75%, Missing); spinal cord: 41.5094% (minimum 75%, Missing); spleen: 55.0000% (minimum 65%, Missing)",-0.1,-0.121053,-0.464286,0,80,unavailable,5.5,1.6,1.8,"choroid plexus: 5.5 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,STEAP1B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000105948,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 55.2419% (minimum 75%, Missing)",0.200932,0.0842593,-0.197581,0,12,partial,11.1,7.9,4.7,"choroid plexus: 11.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),83,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IFT56,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000105982,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.331697,0.268801,0.195513,0,9,partial,3.4,2.9,2.4,"spinal cord: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RNF32,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000106013,True,compatible,,True,True,True,,0.349043,0.29976,0.249162,0,80,unavailable,0.7,0.2,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ANKRD7,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000106125,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 74.4966% (minimum 75%, Missing); choroid plexus: 48.4716% (minimum 75%, Missing); heart muscle: 71.1538% (minimum 75%, Missing); kidney: 69.8113% (minimum 75%, Missing); lung: 54.6798% (minimum 75%, Missing); pituitary gland: 67.2727% (minimum 75%, Missing); smooth muscle: 66.0714% (minimum 70%, Approved); thyroid gland: 63.0682% (minimum 65%, Missing)",-0.0193182,0.00700637,-0.265284,0,2,partial,11.8,4.6,6.5,"choroid plexus: 11.8 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); thyroid gland: 6.5 nTPM (manageable, limit 5); smooth muscle: 5.7 nTPM (vital, limit 2); pituitary gland: 5.4 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 3); heart muscle: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 3); urinary bladder: 4.2 nTPM (protected, limit 3); basal ganglia: 3.8 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 3); pancreas: 3.3 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); cerebral cortex: 2.9 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 2); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 2); small intestine: 2.1 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MINDY4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000106304,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.4,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPAM1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000106328,True,compatible,,True,True,True,,0.35,0.3,0.248964,0,1,partial,0.5,0.1,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FSCN3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000106336,True,compatible,,True,True,True,,0.347475,0.296217,0.2375,0,3,partial,1,1.2,1.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FBXO24,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000106410,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NOBOX,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000106588,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.7682% (minimum 65%, Uncertain); adrenal gland: 46.7797% (minimum 75%, Missing); amygdala: 60.2244% (minimum 75%, Missing); basal ganglia: 59.4096% (minimum 75%, Missing); bone marrow: 44.9093% (minimum 75%, Missing); cerebellum: 65.5360% (minimum 75%, Missing); cerebral cortex: 63.0548% (minimum 75%, Missing); choroid plexus: 48.0119% (minimum 75%, Missing); colon: 52.3861% (minimum 70%, Missing); duodenum: 48.8866% (minimum 75%, Missing); esophagus: 47.4693% (minimum 70%, Missing); heart muscle: 45.5660% (minimum 75%, Missing); hippocampal formation: 62.2423% (minimum 75%, Missing); hypothalamus: 61.7647% (minimum 75%, Missing); kidney: 45.9344% (minimum 75%, Missing); liver: 23.8224% (minimum 75%, Missing); lung: 53.6965% (minimum 75%, Missing); lymph node: 49.4371% (minimum 70%, Missing); midbrain: 57.2614% (minimum 75%, Missing); pancreas: 52.2445% (minimum 75%, Missing); parathyroid gland: 58.7234% (minimum 70%, Missing); pituitary gland: 60.8696% (minimum 75%, Missing); rectum: 53.5774% (minimum 70%, Missing); retina: 70.5109% (minimum 75%, Missing); salivary gland: 56.7234% (minimum 70%, Missing); skeletal muscle: 30.5599% (minimum 75%, Uncertain); skin: 53.4292% (minimum 65%, Missing); small intestine: 50.7087% (minimum 75%, Missing); smooth muscle: 59.9628% (minimum 75%, Uncertain); spinal cord: 55.0741% (minimum 75%, Missing); spleen: 51.2467% (minimum 65%, Missing); stomach: 48.7141% (minimum 70%, Missing); thymus: 41.9817% (minimum 65%, Missing); thyroid gland: 59.6296% (minimum 65%, Missing); tongue: 45.5660% (minimum 70%, Missing); urinary bladder: 52.0755% (minimum 70%, Missing)",-0.230183,-0.24434,-0.511776,0,3,partial,308.9,115.4,133.5,"liver: 308.9 nTPM (vital, limit 1); skeletal muscle: 219.5 nTPM (vital, limit 1); thymus: 133.5 nTPM (manageable, limit 5); bone marrow: 118.5 nTPM (vital, limit 1); tongue: 115.4 nTPM (protected, limit 3); heart muscle: 115.4 nTPM (vital, limit 1); kidney: 113.7 nTPM (vital, limit 1); adrenal gland: 109.9 nTPM (vital, limit 1); esophagus: 106.9 nTPM (protected, limit 3); choroid plexus: 104.6 nTPM (vital, limit 1); stomach: 101.7 nTPM (protected, limit 3); duodenum: 101 nTPM (vital, limit 1); lymph node: 98.8 nTPM (protected, limit 3); adipose tissue: 97.5 nTPM (manageable, limit 5); small intestine: 93.9 nTPM (vital, limit 1); spleen: 91.9 nTPM (manageable, limit 5); urinary bladder: 88.9 nTPM (protected, limit 3); pancreas: 88.3 nTPM (vital, limit 1); colon: 87.8 nTPM (protected, limit 3); skin: 84.2 nTPM (manageable, limit 5); rectum: 83.7 nTPM (protected, limit 3); lung: 83.3 nTPM (vital, limit 1); spinal cord: 78.8 nTPM (vital, limit 1); salivary gland: 73.7 nTPM (protected, limit 3); midbrain: 72.1 nTPM (vital, limit 1); parathyroid gland: 67.9 nTPM (protected, limit 3); basal ganglia: 66 nTPM (vital, limit 1); thyroid gland: 65.4 nTPM (manageable, limit 5); smooth muscle: 64.5 nTPM (vital, limit 1); amygdala: 63.8 nTPM (vital, limit 1); pituitary gland: 62.1 nTPM (vital, limit 1); hypothalamus: 59.8 nTPM (vital, limit 1); hippocampal formation: 58.6 nTPM (vital, limit 1); cerebral cortex: 56.6 nTPM (vital, limit 1); cerebellum: 50.8 nTPM (vital, limit 1); retina: 40.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PSMA2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000106638,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.4829% (minimum 75%, Missing); pancreas: 54.8105% (minimum 75%, Missing)",0.156867,0.0580645,-0.201895,0,80,unavailable,15.5,6,4.5,"pancreas: 15.5 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 3); salivary gland: 5.3 nTPM (protected, limit 3); esophagus: 4.6 nTPM (protected, limit 3); liver: 4.5 nTPM (vital, limit 1); lung: 4 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); small intestine: 3.9 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TBL2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000106648,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.132353,0,2,partial,1.4,0,0,"cerebral cortex: 1.4 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced),52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GALNTL5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000106829,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 59.0253% (minimum 75%, Missing)",0.136058,0.147882,-0.159747,0,80,unavailable,68.1,17.6,26.7,"bone marrow: 68.1 nTPM (vital, limit 1); spinal cord: 30 nTPM (vital, limit 1); thymus: 26.7 nTPM (manageable, limit 5); basal ganglia: 26.3 nTPM (vital, limit 1); retina: 24.3 nTPM (vital, limit 1); pituitary gland: 23.5 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); skeletal muscle: 22.3 nTPM (vital, limit 1); choroid plexus: 21.3 nTPM (vital, limit 1); skin: 19.4 nTPM (manageable, limit 5); spleen: 18 nTPM (manageable, limit 5); urinary bladder: 17.6 nTPM (protected, limit 3); cerebral cortex: 15.8 nTPM (vital, limit 1); hippocampal formation: 15.7 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 3); esophagus: 15.4 nTPM (protected, limit 3); midbrain: 15.2 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); smooth muscle: 13.8 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 3); lung: 12.1 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); small intestine: 11 nTPM (vital, limit 1); tongue: 10.5 nTPM (protected, limit 3); parathyroid gland: 10.2 nTPM (protected, limit 3); rectum: 10.1 nTPM (protected, limit 3); thyroid gland: 9.9 nTPM (manageable, limit 5); salivary gland: 9.7 nTPM (protected, limit 3); colon: 9.6 nTPM (protected, limit 3); adipose tissue: 9 nTPM (manageable, limit 5); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); liver: 5.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TLE4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000107036,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.7619% (minimum 55%, Supported); adrenal gland: 66.3462% (minimum 75%, Missing); bone marrow: 51.3011% (minimum 75%, Missing); cerebellum: 67.3171% (minimum 75%, Missing); cerebral cortex: 72.2513% (minimum 75%, Missing); colon: 63.0137% (minimum 70%, Missing); duodenum: 58.7234% (minimum 75%, Missing); esophagus: 55.6452% (minimum 70%, Missing); heart muscle: 67.3171% (minimum 75%, Missing); kidney: 65.7143% (minimum 75%, Missing); liver: 58.9744% (minimum 75%, Missing); lung: 58.4746% (minimum 75%, Missing); lymph node: 44.9511% (minimum 70%, Missing); pancreas: 57.5000% (minimum 75%, Missing); parathyroid gland: 61.6071% (minimum 70%, Missing); pituitary gland: 74.5946% (minimum 75%, Missing); rectum: 60.2620% (minimum 70%, Missing); retina: 65.7143% (minimum 75%, Missing); salivary gland: 55.6452% (minimum 70%, Missing); skeletal muscle: 44.8052% (minimum 75%, Missing); skin: 51.3011% (minimum 65%, Missing); small intestine: 60.2620% (minimum 75%, Missing); smooth muscle: 51.8797% (minimum 75%, Missing); spleen: 54.5455% (minimum 65%, Missing); stomach: 64.1860% (minimum 70%, Missing); thymus: 48.9362% (minimum 65%, Missing); thyroid gland: 55.8704% (minimum 65%, Missing); tongue: 47.7509% (minimum 70%, Missing); urinary bladder: 56.5574% (minimum 70%, Missing)",-0.160638,-0.250489,-0.301948,0,7,partial,17,16.9,14.4,"skeletal muscle: 17 nTPM (vital, limit 1); lymph node: 16.9 nTPM (protected, limit 3); tongue: 15.1 nTPM (protected, limit 3); thymus: 14.4 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); skin: 13.1 nTPM (manageable, limit 5); smooth muscle: 12.8 nTPM (vital, limit 1); spleen: 11.5 nTPM (manageable, limit 5); salivary gland: 11 nTPM (protected, limit 3); esophagus: 11 nTPM (protected, limit 3); thyroid gland: 10.9 nTPM (manageable, limit 5); urinary bladder: 10.6 nTPM (protected, limit 3); pancreas: 10.2 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); liver: 9.6 nTPM (vital, limit 1); small intestine: 9.1 nTPM (vital, limit 1); rectum: 9.1 nTPM (protected, limit 3); parathyroid gland: 8.6 nTPM (protected, limit 3); colon: 8.1 nTPM (protected, limit 3); stomach: 7.7 nTPM (protected, limit 3); kidney: 7.2 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); adrenal gland: 7 nTPM (vital, limit 1); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); cerebellum / synaptic glomeruli - core: Medium (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RIC1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000107077,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 54.4601% (minimum 65%, Missing); adrenal gland: 55.5024% (minimum 75%, Missing); amygdala: 63.0435% (minimum 75%, Missing); basal ganglia: 60.4167% (minimum 75%, Missing); bone marrow: 28.0872% (minimum 75%, Missing); cerebellum: 23.2465% (minimum 75%, Missing); cerebral cortex: 60.4167% (minimum 75%, Missing); choroid plexus: 41.5771% (minimum 75%, Missing); colon: 46.5863% (minimum 70%, Missing); duodenum: 47.7366% (minimum 75%, Missing); esophagus: 53.9535% (minimum 70%, Missing); heart muscle: 60.7330% (minimum 75%, Missing); hippocampal formation: 59.1837% (minimum 75%, Missing); hypothalamus: 57.7114% (minimum 75%, Missing); kidney: 58.0000% (minimum 75%, Missing); liver: 52.0179% (minimum 75%, Missing); lung: 52.9680% (minimum 75%, Missing); lymph node: 38.2838% (minimum 70%, Missing); midbrain: 61.7021% (minimum 75%, Missing); pancreas: 42.6471% (minimum 75%, Missing); parathyroid gland: 40.2778% (minimum 70%, Missing); pituitary gland: 50.2165% (minimum 75%, Missing); rectum: 42.6471% (minimum 70%, Missing); retina: 29.2929% (minimum 75%, Missing); salivary gland: 50.6550% (minimum 70%, Missing); skeletal muscle: 59.1837% (minimum 75%, Missing); skin: 44.1065% (minimum 65%, Missing); small intestine: 45.3125% (minimum 75%, Missing); smooth muscle: 52.7273% (minimum 75%, Missing); spinal cord: 54.7170% (minimum 75%, Missing); spleen: 46.2151% (minimum 65%, Missing); stomach: 44.1065% (minimum 70%, Missing); thymus: 33.5260% (minimum 65%, Missing); thyroid gland: 47.1545% (minimum 65%, Missing); tongue: 66.6667% (minimum 70%, Missing); urinary bladder: 53.9535% (minimum 70%, Missing)",-0.31474,-0.317162,-0.517535,0,80,unavailable,38.3,18.7,23,"cerebellum: 38.3 nTPM (vital, limit 1); bone marrow: 29.7 nTPM (vital, limit 1); retina: 28 nTPM (vital, limit 1); thymus: 23 nTPM (manageable, limit 5); lymph node: 18.7 nTPM (protected, limit 3); parathyroid gland: 17.2 nTPM (protected, limit 3); choroid plexus: 16.3 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 3); pancreas: 15.6 nTPM (vital, limit 1); stomach: 14.7 nTPM (protected, limit 3); skin: 14.7 nTPM (manageable, limit 5); small intestine: 14 nTPM (vital, limit 1); spleen: 13.5 nTPM (manageable, limit 5); colon: 13.3 nTPM (protected, limit 3); thyroid gland: 13 nTPM (manageable, limit 5); duodenum: 12.7 nTPM (vital, limit 1); pituitary gland: 11.5 nTPM (vital, limit 1); salivary gland: 11.3 nTPM (protected, limit 3); liver: 10.7 nTPM (vital, limit 1); smooth muscle: 10.4 nTPM (vital, limit 1); lung: 10.3 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 3); urinary bladder: 9.9 nTPM (protected, limit 3); adipose tissue: 9.7 nTPM (manageable, limit 5); spinal cord: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); skeletal muscle: 8 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); tongue: 5.8 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KDM4C,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000107105,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 63.3333% (minimum 75%, Missing); hypothalamus: 66.2441% (minimum 75%, Missing); midbrain: 70.8475% (minimum 75%, Missing)",0.35,0.28818,-0.116667,0,7,partial,24.2,0.5,0.5,"cerebral cortex: 24.2 nTPM (vital, limit 1); hypothalamus: 21.3 nTPM (vital, limit 1); midbrain: 17.2 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); hippocampal formation: 7.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - nucleus: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ELAVL2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000107518,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 54.1850% (minimum 75%, Missing); amygdala: 66.1290% (minimum 75%, Missing); basal ganglia: 71.0983% (minimum 75%, Missing); cerebral cortex: 38.8013% (minimum 75%, Missing); choroid plexus: 72.3529% (minimum 75%, Missing); hippocampal formation: 64.3979% (minimum 75%, Missing); pituitary gland: 68.7151% (minimum 75%, Missing); retina: 66.8478% (minimum 75%, Missing); smooth muscle: 68.7151% (minimum 75%, Missing)",0.281818,0.142466,-0.361987,0,80,unavailable,19.4,2.3,0.9,"cerebral cortex: 19.4 nTPM (vital, limit 1); adrenal gland: 10.4 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ATRNL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000107614,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"kidney: 69.2308% (minimum 75%, Missing); lymph node: 68.1818% (minimum 70%, Missing); parathyroid gland: 64.2857% (minimum 70%, Missing); retina: 44.5545% (minimum 75%, Missing); thymus: 58.4416% (minimum 65%, Missing); thyroid gland: 55.5556% (minimum 65%, Missing)",-0.0944444,-0.0571429,-0.304455,0,1,partial,5.6,2.5,3.6,"retina: 5.6 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRDMT1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000108106,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 57.3826% (minimum 70%, Approved)",0.117964,0.11558,-0.126174,0,0,routine_complete,114.3,36,46.5,"bone marrow: 114.3 nTPM (vital, limit 2); thymus: 46.5 nTPM (manageable, limit 5); hippocampal formation: 36.8 nTPM (vital, limit 1); amygdala: 36.5 nTPM (vital, limit 1); cerebral cortex: 36.4 nTPM (vital, limit 2); hypothalamus: 36.1 nTPM (vital, limit 1); esophagus: 36 nTPM (protected, limit 4); lymph node: 34.8 nTPM (protected, limit 3); spinal cord: 34.4 nTPM (vital, limit 1); basal ganglia: 30.6 nTPM (vital, limit 1); pituitary gland: 28.1 nTPM (vital, limit 1); midbrain: 27.2 nTPM (vital, limit 1); cerebellum: 25.9 nTPM (vital, limit 2); spleen: 25.1 nTPM (manageable, limit 10); heart muscle: 24 nTPM (vital, limit 2); choroid plexus: 19.4 nTPM (vital, limit 1); colon: 17.9 nTPM (protected, limit 3); stomach: 17.1 nTPM (protected, limit 4); adrenal gland: 17 nTPM (vital, limit 2); small intestine: 15.7 nTPM (vital, limit 2); adipose tissue: 15.7 nTPM (manageable, limit 10); lung: 15.7 nTPM (vital, limit 2); urinary bladder: 15.7 nTPM (protected, limit 3); skeletal muscle: 14.9 nTPM (vital, limit 2); smooth muscle: 14.5 nTPM (vital, limit 2); kidney: 12.7 nTPM (vital, limit 2); salivary gland: 11.7 nTPM (protected, limit 4); skin: 11.6 nTPM (manageable, limit 10); liver: 11.2 nTPM (vital, limit 2); duodenum: 11 nTPM (vital, limit 2); retina: 9.1 nTPM (vital, limit 1); rectum: 9 nTPM (protected, limit 4); pancreas: 7.5 nTPM (vital, limit 2); parathyroid gland: 6.5 nTPM (protected, limit 4); tongue: 5.4 nTPM (protected, limit 3)",colon / endothelial cells: Low (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,UBE2S,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000108666,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 62.3472% (minimum 75%, Missing); amygdala: 72.4432% (minimum 75%, Missing); basal ganglia: 71.0306% (minimum 75%, Missing); cerebellum: 62.0438% (minimum 75%, Missing); cerebral cortex: 62.5000% (minimum 75%, Missing); choroid plexus: 57.6923% (minimum 75%, Missing); colon: 69.2935% (minimum 70%, Missing); duodenum: 66.4062% (minimum 75%, Missing); heart muscle: 57.6923% (minimum 70%, Approved); hippocampal formation: 71.8310% (minimum 75%, Missing); hypothalamus: 66.9291% (minimum 75%, Missing); kidney: 55.4348% (minimum 75%, Missing); liver: 64.5570% (minimum 75%, Missing); lymph node: 66.9291% (minimum 70%, Missing); midbrain: 69.4823% (minimum 75%, Missing); pancreas: 66.7539% (minimum 75%, Missing); parathyroid gland: 48.6641% (minimum 70%, Missing); pituitary gland: 66.0622% (minimum 75%, Missing); rectum: 67.6393% (minimum 70%, Missing); retina: 50.0982% (minimum 75%, Missing); salivary gland: 68.1818% (minimum 70%, Missing); skeletal muscle: 60.1415% (minimum 75%, Missing); small intestine: 70.8333% (minimum 75%, Missing); smooth muscle: 71.8310% (minimum 75%, Missing); spinal cord: 71.2291% (minimum 75%, Missing); stomach: 66.9291% (minimum 70%, Missing); thymus: 62.0438% (minimum 65%, Missing); tongue: 65.0510% (minimum 70%, Missing)",-0.029562,-0.213359,-0.249018,0,7,partial,25.4,26.9,15.6,"parathyroid gland: 26.9 nTPM (protected, limit 3); retina: 25.4 nTPM (vital, limit 1); kidney: 20.5 nTPM (vital, limit 1); choroid plexus: 18.7 nTPM (vital, limit 1); heart muscle: 18.7 nTPM (vital, limit 2); skeletal muscle: 16.9 nTPM (vital, limit 1); cerebellum: 15.6 nTPM (vital, limit 1); thymus: 15.6 nTPM (manageable, limit 5); adrenal gland: 15.4 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); liver: 14 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 3); thyroid gland: 13.6 nTPM (manageable, limit 5); pituitary gland: 13.1 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); stomach: 12.6 nTPM (protected, limit 3); lymph node: 12.6 nTPM (protected, limit 3); hypothalamus: 12.6 nTPM (vital, limit 1); rectum: 12.2 nTPM (protected, limit 3); salivary gland: 11.9 nTPM (protected, limit 3); colon: 11.3 nTPM (protected, limit 3); midbrain: 11.2 nTPM (vital, limit 1); small intestine: 10.5 nTPM (vital, limit 1); basal ganglia: 10.4 nTPM (vital, limit 1); spinal cord: 10.3 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); hippocampal formation: 10 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); spleen: 9.3 nTPM (manageable, limit 5); urinary bladder: 9.3 nTPM (protected, limit 3); lung: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 3); bone marrow: 7.5 nTPM (vital, limit 1); skin: 7 nTPM (manageable, limit 5)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C17orf75,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000108786,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345006,0.3,0.209085,0,1,partial,4.3,5.9,6.1,"hippocampal formation: 3.4 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HSD17B1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000109171,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 71.4286% (minimum 75%, Missing); colon: 60.2410% (minimum 70%, Missing); esophagus: 51.3479% (minimum 70%, Missing); heart muscle: 50.5051% (minimum 75%, Missing); kidney: 68.3761% (minimum 70%, Approved); liver: 60.5144% (minimum 75%, Missing); lung: 65.7895% (minimum 75%, Missing); parathyroid gland: 57.4713% (minimum 65%, Approved); rectum: 62.5000% (minimum 70%, Missing); retina: 71.5564% (minimum 75%, Missing); skeletal muscle: 36.4964% (minimum 75%, Missing); skin: 55.7880% (minimum 65%, Missing); smooth muscle: 53.9084% (minimum 75%, Missing); thymus: 62.5000% (minimum 65%, Missing); tongue: 29.6736% (minimum 70%, Missing); urinary bladder: 61.0687% (minimum 70%, Missing)",-0.0921199,-0.403264,-0.385036,0,1,partial,69.6,94.8,31.7,"tongue: 94.8 nTPM (protected, limit 3); skeletal muscle: 69.6 nTPM (vital, limit 1); heart muscle: 39.2 nTPM (vital, limit 1); esophagus: 37.9 nTPM (protected, limit 3); smooth muscle: 34.2 nTPM (vital, limit 1); skin: 31.7 nTPM (manageable, limit 5); parathyroid gland: 29.6 nTPM (protected, limit 4); colon: 26.4 nTPM (protected, limit 3); liver: 26.1 nTPM (vital, limit 1); urinary bladder: 25.5 nTPM (protected, limit 3); adipose tissue: 24.2 nTPM (manageable, limit 10); thymus: 24 nTPM (manageable, limit 5); rectum: 24 nTPM (protected, limit 3); lung: 20.8 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (manageable, limit 5); salivary gland: 19.4 nTPM (protected, limit 4); kidney: 18.5 nTPM (vital, limit 2); stomach: 18.1 nTPM (protected, limit 4); small intestine: 16.9 nTPM (vital, limit 2); lymph node: 16.6 nTPM (protected, limit 4); spleen: 16 nTPM (manageable, limit 10); bone marrow: 16 nTPM (vital, limit 1); retina: 15.9 nTPM (vital, limit 1); pancreas: 14.6 nTPM (vital, limit 2); duodenum: 13.1 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 2); choroid plexus: 11.3 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 2); cerebral cortex: 6.1 nTPM (vital, limit 2); midbrain: 6.1 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: High (Approved); skin 2 / epidermal cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLAIN2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000109184,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.0000% (minimum 65%, Missing); adrenal gland: 48.9614% (minimum 75%, Missing); amygdala: 56.7010% (minimum 75%, Missing); basal ganglia: 55.5556% (minimum 75%, Missing); cerebellum: 56.1224% (minimum 75%, Missing); cerebral cortex: 52.8846% (minimum 75%, Missing); choroid plexus: 74.3243% (minimum 75%, Missing); colon: 53.2258% (minimum 70%, Missing); duodenum: 74.3243% (minimum 75%, Missing); esophagus: 62.2642% (minimum 70%, Missing); heart muscle: 58.5106% (minimum 75%, Uncertain); hippocampal formation: 55.5556% (minimum 75%, Missing); hypothalamus: 47.0085% (minimum 75%, Missing); kidney: 53.5714% (minimum 75%, Missing); liver: 37.0787% (minimum 75%, Missing); lung: 65.2174% (minimum 75%, Missing); lymph node: 69.3277% (minimum 70%, Missing); midbrain: 52.3810% (minimum 75%, Missing); pancreas: 65.2174% (minimum 75%, Missing); parathyroid gland: 64.2023% (minimum 70%, Missing); pituitary gland: 51.8868% (minimum 75%, Missing); rectum: 66.8016% (minimum 70%, Missing); retina: 52.0505% (minimum 75%, Missing); salivary gland: 55.7432% (minimum 70%, Missing); skeletal muscle: 59.1398% (minimum 75%, Uncertain); small intestine: 63.7066% (minimum 75%, Missing); smooth muscle: 49.8489% (minimum 75%, Missing); spinal cord: 53.7459% (minimum 75%, Missing); spleen: 64.2023% (minimum 65%, Missing); stomach: 56.1224% (minimum 70%, Missing); thyroid gland: 56.3140% (minimum 65%, Missing); tongue: 60.2190% (minimum 70%, Missing); urinary bladder: 50.1520% (minimum 70%, Missing)",-0.1,-0.19848,-0.379213,0,3,partial,28,16.4,13.5,"liver: 28 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); adrenal gland: 17.2 nTPM (vital, limit 1); smooth muscle: 16.6 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 3); pituitary gland: 15.3 nTPM (vital, limit 1); retina: 15.2 nTPM (vital, limit 1); midbrain: 15 nTPM (vital, limit 1); cerebral cortex: 14.7 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 3); kidney: 14.3 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adipose tissue: 13.5 nTPM (manageable, limit 5); basal ganglia: 13.2 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); salivary gland: 13.1 nTPM (protected, limit 3); cerebellum: 12.9 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 3); thyroid gland: 12.8 nTPM (manageable, limit 5); amygdala: 12.6 nTPM (vital, limit 1); heart muscle: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 3); esophagus: 10 nTPM (protected, limit 3); small intestine: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 3); spleen: 9.2 nTPM (manageable, limit 5); lung: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); rectum: 8.2 nTPM (protected, limit 3); skin: 7.5 nTPM (manageable, limit 5); lymph node: 7.3 nTPM (protected, limit 3); thymus: 6.3 nTPM (manageable, limit 5); duodenum: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DCUN1D4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000109265,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 68.7651% (minimum 75%, Missing); small intestine: 60.1695% (minimum 75%, Missing)",0.275081,0.0634409,-0.148305,0,1,partial,18.8,8.8,2.3,"small intestine: 18.8 nTPM (vital, limit 1); duodenum: 12.9 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 3); rectum: 7.5 nTPM (protected, limit 3); parathyroid gland: 5.8 nTPM (protected, limit 3); cerebral cortex: 5.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CRACD,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000109618,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.0870% (minimum 65%, Missing); adrenal gland: 58.0247% (minimum 75%, Missing); amygdala: 68.1159% (minimum 75%, Missing); basal ganglia: 69.1176% (minimum 75%, Missing); cerebellum: 58.0247% (minimum 75%, Missing); cerebral cortex: 73.4375% (minimum 75%, Missing); colon: 47.9592% (minimum 70%, Missing); duodenum: 50.0000% (minimum 75%, Missing); esophagus: 60.2564% (minimum 70%, Missing); heart muscle: 63.5135% (minimum 75%, Missing); hippocampal formation: 65.2778% (minimum 75%, Missing); hypothalamus: 68.1159% (minimum 75%, Missing); kidney: 37.3016% (minimum 75%, Missing); liver: 15.6667% (minimum 75%, Missing); lung: 55.2941% (minimum 75%, Missing); midbrain: 62.6667% (minimum 75%, Missing); pancreas: 39.4958% (minimum 75%, Missing); parathyroid gland: 59.4937% (minimum 70%, Missing); pituitary gland: 61.0390% (minimum 75%, Missing); rectum: 63.5135% (minimum 70%, Missing); salivary gland: 55.9524% (minimum 70%, Missing); skeletal muscle: 58.7500% (minimum 75%, Missing); skin: 48.4536% (minimum 65%, Missing); small intestine: 38.8430% (minimum 75%, Missing); spinal cord: 54.0230% (minimum 75%, Missing); spleen: 46.0784% (minimum 65%, Missing); stomach: 48.9583% (minimum 70%, Missing); thymus: 48.4536% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); tongue: 65.2778% (minimum 70%, Missing); urinary bladder: 55.9524% (minimum 70%, Missing)",-0.189216,-0.220408,-0.593333,0,80,unavailable,25.3,5.1,5.5,"liver: 25.3 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); spleen: 5.5 nTPM (manageable, limit 5); colon: 5.1 nTPM (protected, limit 3); stomach: 4.9 nTPM (protected, limit 3); duodenum: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); salivary gland: 3.7 nTPM (protected, limit 3); urinary bladder: 3.7 nTPM (protected, limit 3); cerebellum: 3.4 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); esophagus: 3.1 nTPM (protected, limit 3); pituitary gland: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SEPSECS,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000109674,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 18.7500% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); duodenum: 57.6923% (minimum 75%, Missing); esophagus: 50.0000% (minimum 70%, Missing); lymph node: 30.0000% (minimum 70%, Missing); rectum: 51.7241% (minimum 70%, Missing); skin: 39.4737% (minimum 65%, Missing); small intestine: 55.5556% (minimum 75%, Missing); thymus: 6.1224% (minimum 65%, Missing)",-0.588776,-0.4,-0.5625,0,80,unavailable,6.5,3.5,23,"thymus: 23 nTPM (manageable, limit 5); bone marrow: 6.5 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); small intestine: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NEIL3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000109684,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 73.3333% (minimum 75%, Uncertain); duodenum: 68.7500% (minimum 75%, Uncertain); kidney: 15.2778% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Uncertain); lung: 68.7500% (minimum 75%, Uncertain); lymph node: 29.7297% (minimum 70%, Missing); pituitary gland: 47.8261% (minimum 75%, Missing); skin: 57.8947% (minimum 65%, Uncertain); small intestine: 57.8947% (minimum 75%, Uncertain); spleen: 44.0000% (minimum 65%, Uncertain); stomach: 50.0000% (minimum 70%, Uncertain); thymus: 47.8261% (minimum 65%, Missing)",-0.21,-0.402703,-0.597222,0,3,partial,6.1,2.6,1.4,"kidney: 6.1 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CLNK,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000109771,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 58.1006% (minimum 75%, Missing); basal ganglia: 56.5217% (minimum 75%, Missing); cerebellum: 45.2174% (minimum 75%, Missing); cerebral cortex: 58.7571% (minimum 75%, Missing); choroid plexus: 74.2857% (minimum 75%, Missing); heart muscle: 74.8201% (minimum 75%, Missing); hippocampal formation: 55.9140% (minimum 75%, Missing); hypothalamus: 53.8860% (minimum 75%, Missing); kidney: 68.8742% (minimum 70%, Approved); midbrain: 67.0968% (minimum 75%, Missing); pituitary gland: 38.0952% (minimum 75%, Missing); retina: 27.0833% (minimum 75%, Missing); spinal cord: 64.5963% (minimum 75%, Missing)",0.153623,0.0482014,-0.479167,0,2,partial,28,3.5,3.4,"retina: 28 nTPM (vital, limit 1); pituitary gland: 16.9 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); hypothalamus: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 5.7 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 2); lung: 4.3 nTPM (vital, limit 2); choroid plexus: 3.6 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.5 nTPM (protected, limit 3); pancreas: 3.1 nTPM (vital, limit 2); skeletal muscle: 2.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRP2BP,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000109832,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.343289,0.298875,0.051444,0,4,partial,22,1.6,4.6,"cerebral cortex: 22 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); retina: 21.2 nTPM (vital, limit 1); hypothalamus: 18.8 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 6); pituitary gland: 14.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal projections: Medium (Enhanced); hypothalamus / glial cells: Medium (Enhanced); hypothalamus / neuronal cells: Low (Enhanced); hypothalamus / neuronal projections: High (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DDX25,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000109851,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DBX1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000109881,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 68.5962% (minimum 75%, Missing)",0.104777,0.128671,-0.0640376,0,80,unavailable,21.7,9.8,15.4,"choroid plexus: 21.7 nTPM (vital, limit 1); thymus: 15.4 nTPM (manageable, limit 5); bone marrow: 13.6 nTPM (vital, limit 1); duodenum: 10.4 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 3); stomach: 9 nTPM (protected, limit 3); cerebral cortex: 8.9 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); colon: 8.5 nTPM (protected, limit 3); amygdala: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); parathyroid gland: 7.8 nTPM (protected, limit 3); hypothalamus: 6.7 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 3); skin: 6.3 nTPM (manageable, limit 5); retina: 6 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); esophagus: 5.3 nTPM (protected, limit 3); adrenal gland: 5.1 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1); salivary gland: 4 nTPM (protected, limit 3); smooth muscle: 3.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 3); urinary bladder: 3.2 nTPM (protected, limit 3); skeletal muscle: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC34,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000109927,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 61.5385% (minimum 70%, Approved); amygdala: 57.1429% (minimum 75%, Missing); basal ganglia: 34.7826% (minimum 75%, Missing); cerebellum: 36.3636% (minimum 70%, Approved); cerebral cortex: 32.0000% (minimum 70%, Approved); choroid plexus: 38.0952% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); heart muscle: 42.1053% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 40.0000% (minimum 75%, Missing); kidney: 61.5385% (minimum 75%, Missing); liver: 66.6667% (minimum 70%, Approved); lung: 66.6667% (minimum 75%, Missing); midbrain: 53.3333% (minimum 75%, Missing); pancreas: 72.7273% (minimum 75%, Missing); parathyroid gland: 50.0000% (minimum 65%, Approved); pituitary gland: 38.0952% (minimum 75%, Missing); retina: 42.1053% (minimum 75%, Missing); skeletal muscle: 53.3333% (minimum 70%, Approved); spinal cord: 57.1429% (minimum 75%, Missing); thyroid gland: 53.3333% (minimum 60%, Approved)",-0.0666667,-0.15,-0.402174,0,3,partial,1.7,0.8,0.7,"basal ganglia: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TECTA,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000110090,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1435% (minimum 55%, Supported); adrenal gland: 47.8599% (minimum 75%, Missing); amygdala: 66.3073% (minimum 75%, Missing); basal ganglia: 57.6112% (minimum 75%, Missing); bone marrow: 39.0476% (minimum 75%, Missing); cerebral cortex: 64.9077% (minimum 75%, Missing); choroid plexus: 56.5517% (minimum 75%, Missing); colon: 27.3942% (minimum 70%, Missing); duodenum: 26.3666% (minimum 75%, Missing); esophagus: 53.5948% (minimum 70%, Missing); heart muscle: 50.0000% (minimum 75%, Missing); hippocampal formation: 71.9298% (minimum 75%, Missing); hypothalamus: 72.5664% (minimum 75%, Missing); kidney: 39.8703% (minimum 75%, Missing); liver: 27.1823% (minimum 75%, Missing); lung: 50.0000% (minimum 75%, Missing); lymph node: 61.3466% (minimum 70%, Missing); midbrain: 64.2298% (minimum 75%, Missing); pancreas: 51.7895% (minimum 75%, Missing); parathyroid gland: 47.9532% (minimum 70%, Missing); pituitary gland: 63.7306% (minimum 75%, Missing); rectum: 36.2832% (minimum 70%, Missing); retina: 52.9032% (minimum 75%, Missing); salivary gland: 49.3976% (minimum 70%, Missing); skeletal muscle: 71.9298% (minimum 75%, Missing); skin: 60.0000% (minimum 65%, Missing); small intestine: 26.1981% (minimum 75%, Missing); smooth muscle: 42.2680% (minimum 75%, Missing); spleen: 47.9532% (minimum 65%, Missing); stomach: 41.4840% (minimum 70%, Missing); thymus: 64.3979% (minimum 65%, Missing); thyroid gland: 62.1212% (minimum 65%, Missing); tongue: 64.2298% (minimum 70%, Missing); urinary bladder: 57.6112% (minimum 70%, Missing)",-0.170468,-0.426058,-0.488019,0,6,partial,69.3,65.2,26.7,"small intestine: 69.3 nTPM (vital, limit 1); duodenum: 68.7 nTPM (vital, limit 1); liver: 65.9 nTPM (vital, limit 1); colon: 65.2 nTPM (protected, limit 3); rectum: 43.2 nTPM (protected, limit 3); bone marrow: 38.4 nTPM (vital, limit 1); kidney: 37.1 nTPM (vital, limit 1); stomach: 34.7 nTPM (protected, limit 3); smooth muscle: 33.6 nTPM (vital, limit 1); adrenal gland: 26.8 nTPM (vital, limit 1); spleen: 26.7 nTPM (manageable, limit 5); parathyroid gland: 26.7 nTPM (protected, limit 3); salivary gland: 25.2 nTPM (protected, limit 3); lung: 24.6 nTPM (vital, limit 1); heart muscle: 24.6 nTPM (vital, limit 1); adipose tissue: 23.5 nTPM (manageable, limit 15); pancreas: 22.9 nTPM (vital, limit 1); retina: 21.9 nTPM (vital, limit 1); esophagus: 21.3 nTPM (protected, limit 3); choroid plexus: 18.9 nTPM (vital, limit 1); urinary bladder: 18.1 nTPM (protected, limit 3); basal ganglia: 18.1 nTPM (vital, limit 1); skin: 16.4 nTPM (manageable, limit 5); lymph node: 15.5 nTPM (protected, limit 3); thyroid gland: 15 nTPM (manageable, limit 5); pituitary gland: 14 nTPM (vital, limit 1); tongue: 13.7 nTPM (protected, limit 3); midbrain: 13.7 nTPM (vital, limit 1); thymus: 13.6 nTPM (manageable, limit 5); cerebral cortex: 13.3 nTPM (vital, limit 1); amygdala: 12.5 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); skeletal muscle: 9.6 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); spinal cord: 6 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: High (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / goblet cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Low (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CPT1A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000110422,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 37.7926% (minimum 60%, Approved); adrenal gland: 61.9744% (minimum 75%, Missing); bone marrow: 59.4737% (minimum 75%, Missing); cerebellum: 74.8344% (minimum 75%, Missing); cerebral cortex: 71.9745% (minimum 75%, Missing); choroid plexus: 64.0832% (minimum 75%, Missing); colon: 53.3019% (minimum 70%, Missing); duodenum: 67.6647% (minimum 75%, Missing); esophagus: 53.2182% (minimum 70%, Missing); heart muscle: 39.5566% (minimum 75%, Missing); hypothalamus: 74.0175% (minimum 75%, Missing); kidney: 47.9491% (minimum 75%, Missing); liver: 53.9809% (minimum 75%, Missing); lung: 56.5000% (minimum 75%, Missing); lymph node: 60.3203% (minimum 70%, Missing); midbrain: 74.1794% (minimum 75%, Missing); pancreas: 57.5552% (minimum 75%, Missing); parathyroid gland: 42.8571% (minimum 70%, Missing); pituitary gland: 73.0603% (minimum 75%, Missing); rectum: 63.0112% (minimum 70%, Missing); retina: 60.9712% (minimum 75%, Missing); salivary gland: 60.3203% (minimum 70%, Missing); skeletal muscle: 33.7649% (minimum 75%, Missing); skin: 60.9712% (minimum 65%, Missing); small intestine: 63.2463% (minimum 75%, Missing); smooth muscle: 47.2145% (minimum 75%, Missing); spinal cord: 67.5299% (minimum 75%, Missing); spleen: 53.2182% (minimum 65%, Missing); stomach: 61.3020% (minimum 70%, Missing); thymus: 57.7513% (minimum 65%, Missing); thyroid gland: 50.9009% (minimum 65%, Missing); tongue: 29.2494% (minimum 70%, Missing); urinary bladder: 52.0737% (minimum 70%, Missing)",-0.222074,-0.407506,-0.412351,0,3,partial,66.5,82,55.8,"tongue: 82 nTPM (protected, limit 3); skeletal muscle: 66.5 nTPM (vital, limit 1); adipose tissue: 55.8 nTPM (manageable, limit 10); heart muscle: 51.8 nTPM (vital, limit 1); parathyroid gland: 45.2 nTPM (protected, limit 3); smooth muscle: 37.9 nTPM (vital, limit 1); kidney: 36.8 nTPM (vital, limit 1); thyroid gland: 32.7 nTPM (manageable, limit 5); urinary bladder: 31.2 nTPM (protected, limit 3); esophagus: 29.8 nTPM (protected, limit 3); spleen: 29.8 nTPM (manageable, limit 5); colon: 29.7 nTPM (protected, limit 3); liver: 28.9 nTPM (vital, limit 1); lung: 26.1 nTPM (vital, limit 1); pancreas: 25 nTPM (vital, limit 1); thymus: 24.8 nTPM (manageable, limit 5); bone marrow: 23.1 nTPM (vital, limit 1); lymph node: 22.3 nTPM (protected, limit 3); salivary gland: 22.3 nTPM (protected, limit 3); skin: 21.7 nTPM (manageable, limit 5); retina: 21.7 nTPM (vital, limit 1); stomach: 21.4 nTPM (protected, limit 3); adrenal gland: 20.8 nTPM (vital, limit 1); rectum: 19.9 nTPM (protected, limit 3); small intestine: 19.7 nTPM (vital, limit 1); choroid plexus: 19 nTPM (vital, limit 1); spinal cord: 16.3 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); cerebral cortex: 13.2 nTPM (vital, limit 1); pituitary gland: 12.5 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); midbrain: 11.8 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HIPK3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000110693,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 34.4059% (minimum 75%, Missing); cerebral cortex: 69.5000% (minimum 75%, Missing); duodenum: 69.1542% (minimum 75%, Missing); kidney: 56.7347% (minimum 60%, Enhanced); pancreas: 67.8049% (minimum 75%, Missing); skeletal muscle: 60.6987% (minimum 75%, Missing); small intestine: 56.5041% (minimum 75%, Missing)",0.0664948,0.00918367,-0.405941,0,15,partial,26.5,5.7,5.5,"bone marrow: 26.5 nTPM (vital, limit 1); small intestine: 10.7 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 6); skeletal muscle: 9 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 3); skin: 5.5 nTPM (manageable, limit 5); liver: 4.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / fibroblasts: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / endocrine cells: Low (Enhanced); small intestine / paneth cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),87,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / fibrohistiocytic cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / fibrohistiocytic cells; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SOX6,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000110975,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 72.4138% (minimum 75%, Missing)",0.35,0.05,-0.0258621,0,80,unavailable,0.8,0.7,0,,,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SYT10,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000111052,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.2143% (minimum 75%, Missing); amygdala: 62.1212% (minimum 75%, Missing); basal ganglia: 65.6000% (minimum 75%, Missing); bone marrow: 22.9050% (minimum 75%, Missing); cerebellum: 29.9270% (minimum 70%, Approved); cerebral cortex: 50.6173% (minimum 70%, Approved); heart muscle: 57.3427% (minimum 70%, Approved); hippocampal formation: 63.0769% (minimum 75%, Missing); hypothalamus: 59.4203% (minimum 75%, Missing); kidney: 49.3976% (minimum 75%, Missing); liver: 32.4111% (minimum 75%, Missing); lung: 62.5954% (minimum 70%, Approved); midbrain: 63.5659% (minimum 75%, Missing); pituitary gland: 58.5714% (minimum 75%, Missing); retina: 24.1176% (minimum 75%, Missing); smooth muscle: 65.0794% (minimum 75%, Missing); spleen: 64.5669% (minimum 65%, Missing)",-0.00433071,0.0333333,-0.52095,0,4,partial,27.6,3.8,4.9,"bone marrow: 27.6 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); cerebellum: 19.2 nTPM (vital, limit 2); liver: 17.1 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 2); heart muscle: 6.1 nTPM (vital, limit 2); pituitary gland: 5.8 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 2); hippocampal formation: 4.8 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); smooth muscle: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LIN7A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000111247,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 26.7544% (minimum 75%, Missing); colon: 54.9550% (minimum 70%, Missing); duodenum: 54.9550% (minimum 75%, Missing); esophagus: 66.3043% (minimum 70%, Missing); lymph node: 41.2162% (minimum 70%, Missing); rectum: 49.1935% (minimum 70%, Missing); small intestine: 56.4815% (minimum 75%, Missing); spleen: 64.8936% (minimum 65%, Missing); thymus: 30.3483% (minimum 65%, Missing)",-0.346517,-0.287838,-0.482456,0,80,unavailable,16.7,8.7,14,"bone marrow: 16.7 nTPM (vital, limit 1); thymus: 14 nTPM (manageable, limit 5); lymph node: 8.7 nTPM (protected, limit 3); rectum: 6.3 nTPM (protected, limit 3); colon: 5 nTPM (protected, limit 3); duodenum: 5 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 3); liver: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RAD51AP1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000111254,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341837,0.294882,0.227867,0,3,partial,4.1,1.5,1.6,"spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AKAP3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000111305,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349522,0.299283,0.184078,0,80,unavailable,29.5,0.3,0.2,"retina: 29.5 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GSG1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000111644,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.339232,0.298551,0.243869,0,1,partial,10.5,5.4,13.4,"bone marrow: 10.5 nTPM (vital, limit 6); duodenum: 8.2 nTPM (vital, limit 6); small intestine: 7.9 nTPM (vital, limit 6); retina: 1.7 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ACRBP,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000111837,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 42.9752% (minimum 75%, Missing); parathyroid gland: 53.6082% (minimum 70%, Missing); retina: 4.3154% (minimum 75%, Missing)",0.231356,-0.163918,-0.706846,0,80,unavailable,115.3,4.5,0.7,"retina: 115.3 nTPM (vital, limit 1); choroid plexus: 6.9 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAK,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000111911,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.2560% (minimum 65%, Missing); adrenal gland: 55.8366% (minimum 75%, Missing); amygdala: 44.4961% (minimum 75%, Missing); basal ganglia: 48.2353% (minimum 75%, Missing); cerebellum: 55.0864% (minimum 75%, Missing); cerebral cortex: 47.5166% (minimum 75%, Missing); choroid plexus: 74.7396% (minimum 75%, Missing); colon: 60.1677% (minimum 70%, Missing); duodenum: 65.3759% (minimum 75%, Missing); esophagus: 57.1713% (minimum 70%, Missing); heart muscle: 51.2500% (minimum 75%, Missing); hippocampal formation: 44.2901% (minimum 75%, Missing); hypothalamus: 48.5618% (minimum 75%, Missing); kidney: 57.2854% (minimum 75%, Missing); liver: 51.1586% (minimum 75%, Missing); lung: 58.5714% (minimum 75%, Missing); midbrain: 41.9591% (minimum 75%, Missing); pancreas: 60.6765% (minimum 75%, Missing); parathyroid gland: 49.2281% (minimum 70%, Missing); pituitary gland: 67.2131% (minimum 75%, Missing); rectum: 62.8009% (minimum 70%, Missing); retina: 66.4352% (minimum 75%, Missing); salivary gland: 53.6449% (minimum 70%, Missing); skeletal muscle: 20.9031% (minimum 75%, Missing); skin: 62.9386% (minimum 65%, Missing); small intestine: 64.9321% (minimum 75%, Missing); smooth muscle: 63.2159% (minimum 75%, Missing); spinal cord: 33.4109% (minimum 75%, Missing); stomach: 54.2533% (minimum 70%, Missing); thyroid gland: 55.8366% (minimum 65%, Missing); tongue: 26.1146% (minimum 70%, Missing); urinary bladder: 61.8534% (minimum 70%, Missing)",-0.0916342,-0.438854,-0.540969,0,6,partial,108.6,81.2,22.7,"skeletal muscle: 108.6 nTPM (vital, limit 1); tongue: 81.2 nTPM (protected, limit 3); spinal cord: 57.2 nTPM (vital, limit 1); midbrain: 39.7 nTPM (vital, limit 1); hippocampal formation: 36.1 nTPM (vital, limit 1); amygdala: 35.8 nTPM (vital, limit 1); cerebral cortex: 31.7 nTPM (vital, limit 1); basal ganglia: 30.8 nTPM (vital, limit 1); hypothalamus: 30.4 nTPM (vital, limit 1); parathyroid gland: 29.6 nTPM (protected, limit 3); liver: 27.4 nTPM (vital, limit 1); heart muscle: 27.3 nTPM (vital, limit 1); salivary gland: 24.8 nTPM (protected, limit 3); stomach: 24.2 nTPM (protected, limit 3); cerebellum: 23.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (manageable, limit 5); adrenal gland: 22.7 nTPM (vital, limit 1); esophagus: 21.5 nTPM (protected, limit 3); kidney: 21.4 nTPM (vital, limit 1); lung: 20.3 nTPM (vital, limit 1); colon: 19 nTPM (protected, limit 3); pancreas: 18.6 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 3); adipose tissue: 17.4 nTPM (manageable, limit 5); rectum: 17 nTPM (protected, limit 3); skin: 16.9 nTPM (manageable, limit 5); smooth muscle: 16.7 nTPM (vital, limit 1); small intestine: 15.5 nTPM (vital, limit 1); duodenum: 15.2 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); pituitary gland: 14 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); bone marrow: 12 nTPM (vital, limit 2); lymph node: 10.9 nTPM (protected, limit 3); spleen: 10.2 nTPM (manageable, limit 10); choroid plexus: 9.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HINT3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000112029,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 67.0330% (minimum 75%, Missing); bone marrow: 12.2984% (minimum 75%, Missing); cerebellum: 63.5417% (minimum 75%, Missing); cerebral cortex: 70.9302% (minimum 75%, Missing); colon: 55.9633% (minimum 70%, Missing); duodenum: 57.5472% (minimum 75%, Missing); esophagus: 62.8866% (minimum 70%, Missing); kidney: 67.0330% (minimum 75%, Missing); liver: 58.6538% (minimum 75%, Missing); lung: 64.8936% (minimum 75%, Missing); lymph node: 29.6117% (minimum 70%, Missing); pancreas: 67.7778% (minimum 75%, Missing); rectum: 54.9550% (minimum 70%, Missing); retina: 65.5914% (minimum 75%, Missing); skin: 59.2233% (minimum 65%, Missing); small intestine: 59.2233% (minimum 75%, Missing); smooth muscle: 55.9633% (minimum 75%, Missing); spleen: 53.0435% (minimum 65%, Missing); stomach: 57.5472% (minimum 70%, Missing); thymus: 18.6544% (minimum 65%, Missing); thyroid gland: 59.2233% (minimum 65%, Missing); urinary bladder: 61.6162% (minimum 70%, Missing)",-0.463456,-0.403883,-0.627016,0,2,partial,43.5,14.5,26.6,"bone marrow: 43.5 nTPM (vital, limit 1); thymus: 26.6 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 3); spleen: 5.4 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 3); smooth muscle: 4.8 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 3); stomach: 4.5 nTPM (protected, limit 3); duodenum: 4.5 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 3); esophagus: 3.6 nTPM (protected, limit 3); cerebellum: 3.5 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FBXO5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000112038,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 57.1429% (minimum 60%, Enhanced)",0.283333,0.186842,-0.0285714,0,3,partial,2.1,1,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OPRM1,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000112053,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.297669,0.211798,0,2,partial,4.9,0.1,1,"basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; gallbladder; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC26A8,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000112116,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0.9,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IL17F,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000112182,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 27.2727% (minimum 75%, Missing); cerebral cortex: 58.6957% (minimum 75%, Missing); heart muscle: 71.0526% (minimum 75%, Missing); lymph node: 13.6364% (minimum 70%, Missing); parathyroid gland: 62.7907% (minimum 70%, Missing); retina: 67.5000% (minimum 75%, Missing); skeletal muscle: 57.4468% (minimum 75%, Missing); small intestine: 69.2308% (minimum 75%, Missing); smooth muscle: 71.0526% (minimum 75%, Missing); spleen: 36.4865% (minimum 50%, Enhanced); thymus: 17.5325% (minimum 65%, Missing); tongue: 54.0000% (minimum 70%, Missing); urinary bladder: 67.5000% (minimum 70%, Missing)",-0.474675,-0.563636,-0.477273,0,5,partial,7.2,17.1,12.7,"lymph node: 17.1 nTPM (protected, limit 3); thymus: 12.7 nTPM (manageable, limit 5); bone marrow: 7.2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / goblet cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BACH2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000112238,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRDM13,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000112246,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.6364% (minimum 65%, Missing); kidney: 22.7642% (minimum 75%, Missing); pancreas: 60.8696% (minimum 75%, Missing); skeletal muscle: 45.1613% (minimum 75%, Missing)",-0.0136364,0.203226,-0.522358,0,80,unavailable,9.5,0.3,1.6,"kidney: 9.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SIM1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000112273,True,compatible,,True,True,True,,0.35,0.3,0.245501,0,2,partial,0.4,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HDGFL1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000112282,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.5000% (minimum 75%, Missing); bone marrow: 38.8732% (minimum 75%, Missing); cerebellum: 54.1176% (minimum 75%, Missing); cerebral cortex: 66.0287% (minimum 75%, Missing); colon: 57.5000% (minimum 70%, Missing); duodenum: 55.4217% (minimum 75%, Missing); esophagus: 62.7273% (minimum 70%, Missing); heart muscle: 68.6567% (minimum 75%, Missing); kidney: 57.9832% (minimum 75%, Missing); liver: 64.4860% (minimum 75%, Missing); lung: 58.9744% (minimum 75%, Missing); lymph node: 48.7633% (minimum 70%, Missing); pancreas: 57.2614% (minimum 75%, Missing); parathyroid gland: 43.8095% (minimum 70%, Missing); pituitary gland: 70.0508% (minimum 75%, Missing); rectum: 53.2819% (minimum 70%, Missing); retina: 55.4217% (minimum 75%, Missing); salivary gland: 52.6718% (minimum 70%, Missing); skeletal muscle: 65.7143% (minimum 75%, Missing); skin: 55.2000% (minimum 65%, Missing); small intestine: 57.2614% (minimum 75%, Missing); smooth muscle: 57.9832% (minimum 75%, Missing); spleen: 52.4715% (minimum 65%, Missing); stomach: 54.9801% (minimum 70%, Missing); thymus: 44.0895% (minimum 65%, Missing); thyroid gland: 49.6403% (minimum 65%, Missing); tongue: 58.7234% (minimum 70%, Missing); urinary bladder: 58.4746% (minimum 70%, Missing)",-0.209105,-0.261905,-0.361268,0,80,unavailable,21.7,17.7,17.5,"bone marrow: 21.7 nTPM (vital, limit 1); parathyroid gland: 17.7 nTPM (protected, limit 3); thymus: 17.5 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 3); thyroid gland: 14 nTPM (manageable, limit 5); spleen: 12.5 nTPM (manageable, limit 5); salivary gland: 12.4 nTPM (protected, limit 3); rectum: 12.1 nTPM (protected, limit 3); cerebellum: 11.7 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 3); skin: 11.2 nTPM (manageable, limit 5); retina: 11.1 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); pancreas: 10.3 nTPM (vital, limit 1); small intestine: 10.3 nTPM (vital, limit 1); colon: 10.2 nTPM (protected, limit 3); adrenal gland: 10.2 nTPM (vital, limit 1); smooth muscle: 10 nTPM (vital, limit 1); kidney: 10 nTPM (vital, limit 1); urinary bladder: 9.8 nTPM (protected, limit 3); tongue: 9.7 nTPM (protected, limit 3); lung: 9.6 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 3); liver: 7.6 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); skeletal muscle: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MED23,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000112541,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 70.2128% (minimum 75%, Missing); basal ganglia: 12.9412% (minimum 75%, Missing); cerebellum: 44.0000% (minimum 75%, Missing); heart muscle: 48.5294% (minimum 65%, Supported); hippocampal formation: 63.4615% (minimum 75%, Missing); hypothalamus: 61.1111% (minimum 75%, Missing); kidney: 53.2258% (minimum 75%, Missing); midbrain: 70.2128% (minimum 75%, Missing); pituitary gland: 55.9322% (minimum 75%, Missing); retina: 63.4615% (minimum 75%, Missing); thyroid gland: 49.2537% (minimum 55%, Supported)",-0.0574627,0,-0.620588,0,10,partial,22.2,2.2,3.4,"basal ganglia: 22.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 3); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",cerebellum / white matter cells - cytoplasm/membrane: Low (Supported); kidney / proximal tubules (cell body): Medium (Supported),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PDE10A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000112619,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 72.9167% (minimum 75%, Missing); cerebral cortex: 48.6111% (minimum 60%, Enhanced); hypothalamus: 60.3448% (minimum 75%, Missing); parathyroid gland: 46.0526% (minimum 55%, Enhanced); pituitary gland: 59.3220% (minimum 75%, Missing); retina: 0.5596% (minimum 75%, Missing); skeletal muscle: 21.4724% (minimum 60%, Enhanced); thyroid gland: 46.6667% (minimum 50%, Enhanced); tongue: 55.5556% (minimum 70%, Missing)",-0.0333333,-0.144444,-0.744404,0,1,partial,621.9,4.1,4,"retina: 621.9 nTPM (vital, limit 1); skeletal muscle: 12.8 nTPM (vital, limit 6); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRPH2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000112742,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 57.1184% (minimum 75%, Missing); thymus: 42.3126% (minimum 65%, Missing)",-0.226874,0.108252,-0.178816,0,1,partial,25,7.9,45.4,"thymus: 45.4 nTPM (manageable, limit 5); bone marrow: 25 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 3); rectum: 5.7 nTPM (protected, limit 3); colon: 4.7 nTPM (protected, limit 3); esophagus: 4.6 nTPM (protected, limit 3); small intestine: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 3); retina: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TTK,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000112761,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.196154,0.270588,0.0115385,0,80,unavailable,3.1,0.3,1.8,"cerebellum: 3.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCN6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000112796,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.177766,0.141826,0.139013,0,4,partial,29.7,44.7,49.5,"thyroid gland: 49.5 nTPM (manageable, limit 5); parathyroid gland: 44.7 nTPM (protected, limit 3); retina: 29.7 nTPM (vital, limit 1); kidney: 23.4 nTPM (vital, limit 1); pituitary gland: 19.3 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); cerebral cortex: 14.2 nTPM (vital, limit 1); salivary gland: 13.9 nTPM (protected, limit 3); skeletal muscle: 10.3 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 3); pancreas: 9.4 nTPM (vital, limit 6); hypothalamus: 9.2 nTPM (vital, limit 1); basal ganglia: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); adrenal gland: 8.4 nTPM (vital, limit 1); choroid plexus: 8.4 nTPM (vital, limit 1); thymus: 7.9 nTPM (manageable, limit 5); cerebellum: 7 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 3); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); spleen: 5.5 nTPM (manageable, limit 5); urinary bladder: 5.3 nTPM (protected, limit 3); heart muscle: 4.3 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); small intestine: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENPP5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000112852,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 55.1020% (minimum 75%, Missing); lung: 72.0000% (minimum 75%, Missing)",0.15597,0.118182,-0.19898,0,5,partial,4.4,2.2,2.6,"cerebral cortex: 4.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHB2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000113205,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 74.4681% (minimum 75%, Missing); parathyroid gland: 68.6275% (minimum 70%, Missing); pituitary gland: 67.3077% (minimum 75%, Missing)",0.0230769,-0.0137255,-0.0769231,0,80,unavailable,1.7,1.6,1.7,"pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHB3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000113209,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 70.0000% (minimum 75%, Missing); basal ganglia: 69.2308% (minimum 75%, Missing); cerebral cortex: 61.1650% (minimum 75%, Missing); hippocampal formation: 73.2558% (minimum 75%, Missing); kidney: 73.2558% (minimum 75%, Missing); pancreas: 57.7982% (minimum 75%, Missing); pituitary gland: 67.0213% (minimum 75%, Missing); retina: 73.2558% (minimum 75%, Missing)",0.0659091,0.00786517,-0.172018,0,3,partial,4.6,2.6,2.5,"pancreas: 4.6 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHB5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000113211,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 59.3750% (minimum 75%, Missing); basal ganglia: 55.8824% (minimum 75%, Missing); cerebellum: 57.5758% (minimum 75%, Missing); cerebral cortex: 51.3514% (minimum 75%, Missing); heart muscle: 73.0769% (minimum 75%, Missing); hippocampal formation: 59.3750% (minimum 75%, Missing); hypothalamus: 73.0769% (minimum 75%, Missing); midbrain: 70.3704% (minimum 75%, Missing); parathyroid gland: 51.3514% (minimum 70%, Missing); pituitary gland: 65.5172% (minimum 75%, Missing); retina: 67.8571% (minimum 75%, Missing); smooth muscle: 67.8571% (minimum 75%, Missing); spinal cord: 63.3333% (minimum 75%, Missing)",0.0537037,-0.186486,-0.236486,0,80,unavailable,1.8,1.8,0.8,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHB6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000113396,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 46.6063% (minimum 75%, Missing); heart muscle: 47.5751% (minimum 75%, Missing); retina: 74.1007% (minimum 75%, Missing)",0.0366667,0.134008,-0.283937,0,4,partial,23.6,4.1,9.4,"adrenal gland: 23.6 nTPM (vital, limit 1); heart muscle: 22.7 nTPM (vital, limit 1); thymus: 9.4 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); pituitary gland: 5.9 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 3); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC27A6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000113525,True,compatible,,True,True,True,,0.324528,0.28,0.159649,0,6,partial,0.8,0.2,0.4,,,49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IL5,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000113966,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 57.6271% (minimum 75%, Missing); amygdala: 62.3853% (minimum 75%, Missing); basal ganglia: 53.1250% (minimum 75%, Missing); cerebellum: 57.1429% (minimum 75%, Missing); cerebral cortex: 46.5753% (minimum 75%, Missing); choroid plexus: 70.8333% (minimum 75%, Missing); heart muscle: 67.3267% (minimum 75%, Missing); hippocampal formation: 57.6271% (minimum 75%, Missing); hypothalamus: 57.6271% (minimum 75%, Missing); kidney: 48.2270% (minimum 75%, Missing); liver: 73.1183% (minimum 75%, Missing); lung: 58.1197% (minimum 75%, Missing); midbrain: 65.3846% (minimum 75%, Missing); pancreas: 67.3267% (minimum 75%, Missing); parathyroid gland: 35.6021% (minimum 70%, Missing); pituitary gland: 62.9630% (minimum 75%, Missing); retina: 15.5963% (minimum 75%, Missing); salivary gland: 54.8387% (minimum 70%, Missing); smooth muscle: 62.3853% (minimum 75%, Missing); spinal cord: 68.6869% (minimum 75%, Missing); thyroid gland: 56.1983% (minimum 65%, Missing); urinary bladder: 68.6869% (minimum 70%, Missing)",-0.0880165,-0.343979,-0.594037,0,2,partial,36.8,12.3,5.3,"retina: 36.8 nTPM (vital, limit 1); parathyroid gland: 12.3 nTPM (protected, limit 3); cerebral cortex: 7.8 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 3); thyroid gland: 5.3 nTPM (manageable, limit 5); cerebellum: 5.1 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 3); choroid plexus: 2.8 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ARL6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000114098,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.7245% (minimum 60%, Approved); adrenal gland: 57.8788% (minimum 75%, Missing); amygdala: 57.7039% (minimum 75%, Missing); basal ganglia: 58.4098% (minimum 75%, Missing); bone marrow: 24.2079% (minimum 75%, Missing); cerebellum: 33.3916% (minimum 75%, Missing); cerebral cortex: 45.5847% (minimum 75%, Missing); choroid plexus: 47.1605% (minimum 75%, Missing); colon: 53.9548% (minimum 70%, Missing); duodenum: 62.0130% (minimum 75%, Missing); esophagus: 48.4772% (minimum 70%, Missing); heart muscle: 53.2033% (minimum 75%, Missing); hippocampal formation: 57.7039% (minimum 75%, Missing); hypothalamus: 52.3288% (minimum 75%, Missing); kidney: 51.2064% (minimum 75%, Missing); liver: 53.8028% (minimum 70%, Approved); lung: 54.7278% (minimum 75%, Missing); lymph node: 47.9899% (minimum 65%, Approved); midbrain: 56.8452% (minimum 75%, Missing); pancreas: 58.0547% (minimum 75%, Missing); parathyroid gland: 48.1108% (minimum 70%, Missing); pituitary gland: 61.4148% (minimum 75%, Missing); rectum: 51.7615% (minimum 70%, Missing); retina: 42.9213% (minimum 75%, Missing); salivary gland: 61.0224% (minimum 70%, Missing); skeletal muscle: 33.8053% (minimum 75%, Missing); skin: 60.6349% (minimum 65%, Missing); small intestine: 59.3168% (minimum 75%, Missing); smooth muscle: 44.8357% (minimum 75%, Missing); spinal cord: 54.5714% (minimum 75%, Missing); spleen: 55.2023% (minimum 65%, Missing); stomach: 56.0117% (minimum 70%, Missing); thymus: 46.9287% (minimum 65%, Missing); thyroid gland: 47.9899% (minimum 65%, Missing); tongue: 36.3810% (minimum 70%, Missing); urinary bladder: 47.1605% (minimum 70%, Missing)",-0.180713,-0.33619,-0.507921,0,6,partial,59.8,33.4,21.6,"bone marrow: 59.8 nTPM (vital, limit 1); cerebellum: 38.1 nTPM (vital, limit 1); skeletal muscle: 37.4 nTPM (vital, limit 1); tongue: 33.4 nTPM (protected, limit 3); retina: 25.4 nTPM (vital, limit 1); smooth muscle: 23.5 nTPM (vital, limit 1); cerebral cortex: 22.8 nTPM (vital, limit 1); thymus: 21.6 nTPM (manageable, limit 5); urinary bladder: 21.4 nTPM (protected, limit 3); choroid plexus: 21.4 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 4); thyroid gland: 20.7 nTPM (manageable, limit 5); parathyroid gland: 20.6 nTPM (protected, limit 3); esophagus: 20.3 nTPM (protected, limit 3); adipose tissue: 20.1 nTPM (manageable, limit 10); kidney: 18.2 nTPM (vital, limit 1); rectum: 17.8 nTPM (protected, limit 3); hypothalamus: 17.4 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); liver: 16.4 nTPM (vital, limit 2); colon: 16.3 nTPM (protected, limit 3); spinal cord: 15.9 nTPM (vital, limit 1); lung: 15.8 nTPM (vital, limit 1); spleen: 15.5 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 3); midbrain: 14.5 nTPM (vital, limit 1); hippocampal formation: 14 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); adrenal gland: 13.9 nTPM (vital, limit 1); pancreas: 13.8 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); skin: 12.4 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 3); pituitary gland: 12 nTPM (vital, limit 1); duodenum: 11.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ARMC8,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000114349,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 0.1104% (minimum 75%, Missing)",0.25,0.3,-0.748896,0,0,routine_complete,1086,0.2,0.4,"retina: 1086 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GNAT1,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000114487,True,compatible,,True,True,True,,0.35,0.3,0.231013,0,1,partial,0.3,0.1,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MORC1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000114547,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.296174,0.236269,0,3,partial,2.9,14.1,6.8,"salivary gland: 14.1 nTPM (protected, limit 6); basal ganglia: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ROPN1B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000114656,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.185937,0.230435,0.0762548,0,80,unavailable,4.5,1.6,4.2,"choroid plexus: 4.5 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP92,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000114739,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 48.0769% (minimum 75%, Missing); amygdala: 55.5556% (minimum 75%, Missing); basal ganglia: 59.5238% (minimum 75%, Missing); cerebellum: 34.2466% (minimum 70%, Approved); cerebral cortex: 51.0204% (minimum 70%, Approved); colon: 64.1026% (minimum 70%, Missing); heart muscle: 65.7895% (minimum 75%, Missing); hippocampal formation: 59.5238% (minimum 75%, Missing); hypothalamus: 56.8182% (minimum 75%, Missing); kidney: 59.5238% (minimum 75%, Missing); liver: 53.1915% (minimum 70%, Approved); lung: 67.5676% (minimum 70%, Approved); midbrain: 60.9756% (minimum 75%, Missing); pancreas: 51.0204% (minimum 75%, Missing); parathyroid gland: 43.8596% (minimum 70%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); rectum: 69.4444% (minimum 70%, Missing); retina: 28.4091% (minimum 75%, Missing); salivary gland: 59.5238% (minimum 65%, Approved); skeletal muscle: 30.1205% (minimum 70%, Approved); small intestine: 69.4444% (minimum 75%, Missing); smooth muscle: 73.5294% (minimum 75%, Missing); spinal cord: 58.1395% (minimum 75%, Missing); stomach: 62.5000% (minimum 70%, Missing); thymus: 38.4615% (minimum 65%, Missing); thyroid gland: 62.5000% (minimum 65%, Missing); tongue: 48.0769% (minimum 70%, Missing); urinary bladder: 64.1026% (minimum 70%, Missing)",-0.265385,-0.261404,-0.465909,0,3,partial,6.3,3.2,4,"retina: 6.3 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 2); cerebellum: 4.8 nTPM (vital, limit 2); parathyroid gland: 3.2 nTPM (protected, limit 3); adrenal gland: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 2); liver: 2.2 nTPM (vital, limit 2); amygdala: 2 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ACVR2B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000114757,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 24.7368% (minimum 75%, Missing); basal ganglia: 27.3256% (minimum 75%, Missing); cerebellum: 69.1176% (minimum 75%, Missing); cerebral cortex: 10.6576% (minimum 75%, Missing); hippocampal formation: 15.9864% (minimum 75%, Missing); hypothalamus: 28.4848% (minimum 75%, Missing); midbrain: 14.9682% (minimum 75%, Missing); pancreas: 32.1918% (minimum 60%, Enhanced); parathyroid gland: 13.8643% (minimum 70%, Missing); pituitary gland: 47.9592% (minimum 75%, Missing); retina: 24.1026% (minimum 75%, Missing); spinal cord: 8.7850% (minimum 75%, Missing); thymus: 64.3836% (minimum 65%, Missing)",-0.00616438,-0.561357,-0.66215,0,3,partial,48.8,29.2,2.6,"spinal cord: 48.8 nTPM (vital, limit 1); cerebral cortex: 39.4 nTPM (vital, limit 1); parathyroid gland: 29.2 nTPM (protected, limit 3); midbrain: 26.7 nTPM (vital, limit 1); hippocampal formation: 24.7 nTPM (vital, limit 1); retina: 14.8 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 6); pituitary gland: 5.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder / glandular cells; salivary gland; salivary gland / glandular cells; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PEX5L,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000114982,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9846% (minimum 60%, Approved); adrenal gland: 60.1660% (minimum 75%, Missing); bone marrow: 49.6575% (minimum 75%, Missing); cerebral cortex: 64.7321% (minimum 75%, Missing); choroid plexus: 67.1296% (minimum 75%, Missing); colon: 55.9846% (minimum 70%, Missing); duodenum: 67.4419% (minimum 75%, Missing); esophagus: 62.7706% (minimum 70%, Missing); heart muscle: 58.4677% (minimum 75%, Missing); kidney: 62.7706% (minimum 75%, Missing); liver: 70.0483% (minimum 75%, Missing); lung: 60.1660% (minimum 75%, Missing); lymph node: 64.4444% (minimum 70%, Missing); pancreas: 60.4167% (minimum 75%, Missing); parathyroid gland: 49.8282% (minimum 70%, Missing); pituitary gland: 63.0435% (minimum 75%, Missing); rectum: 68.7204% (minimum 70%, Missing); retina: 70.3883% (minimum 75%, Missing); salivary gland: 54.3071% (minimum 70%, Missing); skeletal muscle: 30.7203% (minimum 70%, Approved); skin: 58.0000% (minimum 65%, Missing); small intestine: 55.5556% (minimum 75%, Missing); smooth muscle: 58.7045% (minimum 70%, Approved); spleen: 59.4262% (minimum 65%, Missing); stomach: 60.4167% (minimum 70%, Missing); thymus: 53.3088% (minimum 65%, Missing); thyroid gland: 53.7037% (minimum 65%, Missing); tongue: 41.6667% (minimum 70%, Missing); urinary bladder: 53.5055% (minimum 65%, Approved)",-0.116912,-0.283333,-0.392797,0,8,partial,32.7,20.3,12.7,"skeletal muscle: 32.7 nTPM (vital, limit 2); tongue: 20.3 nTPM (protected, limit 3); bone marrow: 14.7 nTPM (vital, limit 1); parathyroid gland: 14.6 nTPM (protected, limit 3); thymus: 12.7 nTPM (manageable, limit 5); urinary bladder: 12.6 nTPM (protected, limit 4); thyroid gland: 12.5 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 3); small intestine: 11.6 nTPM (vital, limit 1); adipose tissue: 11.4 nTPM (manageable, limit 10); colon: 11.4 nTPM (protected, limit 3); skin: 10.5 nTPM (manageable, limit 5); heart muscle: 10.3 nTPM (vital, limit 1); smooth muscle: 10.2 nTPM (vital, limit 2); spleen: 9.9 nTPM (manageable, limit 5); lung: 9.6 nTPM (vital, limit 1); adrenal gland: 9.6 nTPM (vital, limit 1); pancreas: 9.5 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 3); esophagus: 8.6 nTPM (protected, limit 3); kidney: 8.6 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); lymph node: 8 nTPM (protected, limit 3); cerebral cortex: 7.9 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 3); liver: 6.2 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KANSL3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000115008,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 43.9130% (minimum 70%, Missing); urinary bladder: 28.7749% (minimum 70%, Missing)",0.276606,-0.412251,0.0645161,0,80,unavailable,2.3,25,0.8,"urinary bladder: 25 nTPM (protected, limit 3); esophagus: 12.9 nTPM (protected, limit 3); lung: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IL1A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000115159,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 54.1538% (minimum 75%, Missing); basal ganglia: 52.2255% (minimum 75%, Missing); bone marrow: 57.1429% (minimum 75%, Missing); cerebellum: 49.8584% (minimum 75%, Missing); cerebral cortex: 53.9877% (minimum 75%, Missing); colon: 49.4382% (minimum 70%, Missing); duodenum: 55.6962% (minimum 75%, Missing); esophagus: 47.1850% (minimum 70%, Missing); heart muscle: 74.5763% (minimum 75%, Missing); hippocampal formation: 54.6584% (minimum 75%, Missing); hypothalamus: 64.7059% (minimum 75%, Missing); kidney: 69.5652% (minimum 75%, Missing); lung: 61.3240% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 72.7273% (minimum 75%, Missing); parathyroid gland: 47.0588% (minimum 70%, Missing); rectum: 50.2857% (minimum 70%, Missing); retina: 65.4275% (minimum 75%, Missing); salivary gland: 54.8287% (minimum 70%, Missing); skeletal muscle: 42.5121% (minimum 75%, Missing); skin: 59.2593% (minimum 65%, Missing); small intestine: 53.4954% (minimum 75%, Missing); smooth muscle: 74.8936% (minimum 75%, Missing); spinal cord: 71.8367% (minimum 75%, Missing); stomach: 50.8671% (minimum 70%, Missing); thyroid gland: 59.6610% (minimum 65%, Missing); tongue: 56.2300% (minimum 70%, Missing); urinary bladder: 56.0510% (minimum 70%, Missing)",-0.0574074,-0.229412,-0.324879,0,8,partial,23.8,19.8,12.1,"skeletal muscle: 23.8 nTPM (vital, limit 1); parathyroid gland: 19.8 nTPM (protected, limit 3); esophagus: 19.7 nTPM (protected, limit 3); colon: 18 nTPM (protected, limit 3); cerebellum: 17.7 nTPM (vital, limit 1); rectum: 17.4 nTPM (protected, limit 3); stomach: 17 nTPM (protected, limit 3); basal ganglia: 16.1 nTPM (vital, limit 1); small intestine: 15.3 nTPM (vital, limit 1); cerebral cortex: 15 nTPM (vital, limit 1); amygdala: 14.9 nTPM (vital, limit 1); hippocampal formation: 14.6 nTPM (vital, limit 1); salivary gland: 14.5 nTPM (protected, limit 3); duodenum: 14 nTPM (vital, limit 1); urinary bladder: 13.8 nTPM (protected, limit 3); tongue: 13.7 nTPM (protected, limit 3); bone marrow: 13.2 nTPM (vital, limit 1); skin: 12.1 nTPM (manageable, limit 5); thyroid gland: 11.9 nTPM (manageable, limit 5); lung: 11.1 nTPM (vital, limit 1); hypothalamus: 9.6 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); midbrain: 8.8 nTPM (vital, limit 1); spleen: 8.3 nTPM (manageable, limit 5); adipose tissue: 7.9 nTPM (manageable, limit 5); kidney: 7.7 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 3); pancreas: 6.6 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); smooth muscle: 5.9 nTPM (vital, limit 1); thymus: 5.9 nTPM (manageable, limit 5); adrenal gland: 5.5 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GPD2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000115163,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 37.2881% (minimum 75%, Missing); colon: 43.1373% (minimum 70%, Missing); duodenum: 35.4839% (minimum 75%, Missing); esophagus: 38.5965% (minimum 70%, Missing); lymph node: 23.4043% (minimum 70%, Missing); rectum: 45.8333% (minimum 70%, Missing); skin: 38.5965% (minimum 65%, Missing); small intestine: 44.0000% (minimum 75%, Missing); spleen: 52.3810% (minimum 65%, Missing); stomach: 57.8947% (minimum 70%, Missing); thymus: 14.4737% (minimum 65%, Missing)",-0.505263,-0.465957,-0.395161,0,11,partial,4,7.2,13,"thymus: 13 nTPM (manageable, limit 5); lymph node: 7.2 nTPM (protected, limit 3); duodenum: 4 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); small intestine: 2.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / eccrine glands: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CENPA,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000115194,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 69.8745% (minimum 75%, Missing)",0.35,0.3,-0.0512552,0,1,partial,28.8,0.5,0.2,"cerebral cortex: 28.8 nTPM (vital, limit 1); amygdala: 15.9 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); heart muscle: 7.7 nTPM (vital, limit 6)",cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC30A3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000115239,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.5000% (minimum 65%, Uncertain); adrenal gland: 54.8780% (minimum 75%, Missing); amygdala: 41.5385% (minimum 75%, Missing); basal ganglia: 40.9091% (minimum 75%, Missing); bone marrow: 48.0427% (minimum 75%, Missing); cerebellum: 59.7345% (minimum 75%, Missing); cerebral cortex: 41.9255% (minimum 75%, Missing); choroid plexus: 48.0427% (minimum 75%, Missing); colon: 64.9038% (minimum 70%, Missing); duodenum: 67.8392% (minimum 75%, Missing); esophagus: 62.2120% (minimum 70%, Missing); heart muscle: 59.4714% (minimum 75%, Missing); hippocampal formation: 46.5517% (minimum 75%, Missing); hypothalamus: 44.4079% (minimum 75%, Missing); kidney: 61.0860% (minimum 75%, Missing); liver: 57.6923% (minimum 75%, Missing); lung: 58.1897% (minimum 75%, Missing); lymph node: 55.7851% (minimum 70%, Missing); midbrain: 39.9408% (minimum 75%, Missing); pancreas: 65.2174% (minimum 75%, Missing); parathyroid gland: 57.4468% (minimum 70%, Missing); pituitary gland: 48.9130% (minimum 75%, Missing); rectum: 63.3803% (minimum 70%, Missing); retina: 37.8151% (minimum 75%, Missing); salivary gland: 61.0860% (minimum 70%, Missing); skeletal muscle: 67.1642% (minimum 75%, Missing); skin: 60.0000% (minimum 65%, Missing); small intestine: 61.9266% (minimum 75%, Missing); smooth muscle: 63.3803% (minimum 75%, Missing); spinal cord: 54.2169% (minimum 75%, Missing); spleen: 52.1236% (minimum 65%, Missing); stomach: 66.1765% (minimum 70%, Missing); thymus: 44.7020% (minimum 65%, Missing); thyroid gland: 54.6559% (minimum 65%, Missing); tongue: 65.2174% (minimum 70%, Missing); urinary bladder: 64.2857% (minimum 70%, Missing)",-0.20298,-0.142149,-0.371849,0,6,partial,22.2,10.7,16.7,"retina: 22.2 nTPM (vital, limit 1); midbrain: 20.3 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); amygdala: 19 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); thymus: 16.7 nTPM (manageable, limit 5); hippocampal formation: 15.5 nTPM (vital, limit 1); bone marrow: 14.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); pituitary gland: 14.1 nTPM (vital, limit 1); spleen: 12.4 nTPM (manageable, limit 5); spinal cord: 11.4 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (manageable, limit 5); adrenal gland: 11.1 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 3); parathyroid gland: 10 nTPM (protected, limit 3); liver: 9.9 nTPM (vital, limit 1); lung: 9.7 nTPM (vital, limit 1); heart muscle: 9.2 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); skin: 9 nTPM (manageable, limit 5); kidney: 8.6 nTPM (vital, limit 1); salivary gland: 8.6 nTPM (protected, limit 3); small intestine: 8.3 nTPM (vital, limit 1); esophagus: 8.2 nTPM (protected, limit 3); adipose tissue: 8.1 nTPM (manageable, limit 5); smooth muscle: 7.8 nTPM (vital, limit 1); rectum: 7.8 nTPM (protected, limit 3); urinary bladder: 7.5 nTPM (protected, limit 3); colon: 7.3 nTPM (protected, limit 3); pancreas: 7.2 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 3); stomach: 6.9 nTPM (protected, limit 3); skeletal muscle: 6.6 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ASB3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000115252,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 72.2105% (minimum 75%, Missing); cerebellum: 48.0392% (minimum 75%, Missing); cerebral cortex: 61.1408% (minimum 75%, Missing); heart muscle: 71.1618% (minimum 75%, Missing); hippocampal formation: 67.1233% (minimum 75%, Missing); kidney: 46.0403% (minimum 75%, Missing); spinal cord: 68.8755% (minimum 75%, Missing); thyroid gland: 45.1910% (minimum 65%, Missing)",-0.19809,0.050547,-0.289597,0,2,partial,40.2,11.4,41.6,"thyroid gland: 41.6 nTPM (manageable, limit 5); kidney: 40.2 nTPM (vital, limit 1); cerebellum: 37.1 nTPM (vital, limit 1); cerebral cortex: 21.8 nTPM (vital, limit 1); hippocampal formation: 16.8 nTPM (vital, limit 1); spinal cord: 15.5 nTPM (vital, limit 1); heart muscle: 13.9 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); colon: 11.4 nTPM (protected, limit 3); smooth muscle: 11.2 nTPM (vital, limit 2); adipose tissue: 10.1 nTPM (manageable, limit 5); urinary bladder: 9.4 nTPM (protected, limit 3); thymus: 7.8 nTPM (manageable, limit 5); hypothalamus: 7.4 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); esophagus: 4.8 nTPM (protected, limit 4); tongue: 4.3 nTPM (protected, limit 3); adrenal gland: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PDE1A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000115257,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.301039,0.278626,0.152817,0,80,unavailable,6.9,1.4,3.3,"pituitary gland: 6.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCSK4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000115274,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.6325% (minimum 65%, Missing); adrenal gland: 61.2352% (minimum 75%, Missing); amygdala: 63.5744% (minimum 75%, Missing); basal ganglia: 64.0110% (minimum 75%, Missing); bone marrow: 69.6562% (minimum 75%, Missing); cerebellum: 56.1446% (minimum 75%, Missing); cerebral cortex: 61.6402% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); duodenum: 71.2538% (minimum 75%, Missing); esophagus: 60.6771% (minimum 70%, Missing); heart muscle: 70.4992% (minimum 75%, Missing); hippocampal formation: 65.5415% (minimum 75%, Missing); hypothalamus: 65.5415% (minimum 75%, Missing); kidney: 63.6612% (minimum 75%, Missing); liver: 59.8203% (minimum 75%, Missing); lung: 64.9930% (minimum 75%, Missing); midbrain: 69.5522% (minimum 75%, Missing); pancreas: 53.3792% (minimum 75%, Missing); pituitary gland: 53.2571% (minimum 75%, Missing); retina: 72.0247% (minimum 75%, Missing); salivary gland: 61.6402% (minimum 70%, Missing); skeletal muscle: 61.6402% (minimum 75%, Missing); skin: 54.0603% (minimum 65%, Missing); small intestine: 66.6667% (minimum 75%, Missing); spinal cord: 70.2866% (minimum 75%, Missing); stomach: 59.4388% (minimum 70%, Missing); thyroid gland: 55.0177% (minimum 65%, Missing); urinary bladder: 64.0110% (minimum 70%, Missing)",-0.109397,-0.105612,-0.217429,0,80,unavailable,40.9,31.8,39.6,"pituitary gland: 40.9 nTPM (vital, limit 1); pancreas: 40.7 nTPM (vital, limit 1); skin: 39.6 nTPM (manageable, limit 5); thyroid gland: 38.1 nTPM (manageable, limit 5); cerebellum: 36.4 nTPM (vital, limit 1); stomach: 31.8 nTPM (protected, limit 3); liver: 31.3 nTPM (vital, limit 1); esophagus: 30.2 nTPM (protected, limit 3); adrenal gland: 29.5 nTPM (vital, limit 1); cerebral cortex: 29 nTPM (vital, limit 1); skeletal muscle: 29 nTPM (vital, limit 1); salivary gland: 29 nTPM (protected, limit 3); amygdala: 26.7 nTPM (vital, limit 1); kidney: 26.6 nTPM (vital, limit 1); urinary bladder: 26.2 nTPM (protected, limit 3); basal ganglia: 26.2 nTPM (vital, limit 1); adipose tissue: 25.5 nTPM (manageable, limit 5); lung: 25.1 nTPM (vital, limit 1); hypothalamus: 24.5 nTPM (vital, limit 1); hippocampal formation: 24.5 nTPM (vital, limit 1); spleen: 23.9 nTPM (manageable, limit 5); colon: 23.3 nTPM (protected, limit 3); small intestine: 23.3 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); bone marrow: 20.3 nTPM (vital, limit 1); spinal cord: 19.7 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); parathyroid gland: 18.9 nTPM (protected, limit 3); duodenum: 18.8 nTPM (vital, limit 1); lymph node: 18.4 nTPM (protected, limit 3); retina: 18.1 nTPM (vital, limit 1); choroid plexus: 15.5 nTPM (vital, limit 1); smooth muscle: 14.2 nTPM (vital, limit 1); thymus: 12.5 nTPM (manageable, limit 5); rectum: 11.9 nTPM (protected, limit 3); tongue: 8.8 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,INO80B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000115970,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0773% (minimum 65%, Uncertain); adrenal gland: 58.3333% (minimum 75%, Missing); amygdala: 73.6842% (minimum 75%, Missing); basal ganglia: 68.8525% (minimum 75%, Missing); bone marrow: 59.1549% (minimum 75%, Missing); cerebral cortex: 74.5562% (minimum 75%, Missing); choroid plexus: 43.5986% (minimum 75%, Missing); colon: 58.8785% (minimum 70%, Missing); esophagus: 56.7568% (minimum 70%, Missing); heart muscle: 59.1549% (minimum 75%, Uncertain); hippocampal formation: 72.0000% (minimum 75%, Missing); hypothalamus: 71.5909% (minimum 75%, Missing); kidney: 57.5342% (minimum 75%, Missing); liver: 42.7119% (minimum 75%, Missing); lung: 57.0136% (minimum 75%, Missing); lymph node: 47.3684% (minimum 70%, Missing); midbrain: 70.7865% (minimum 75%, Missing); pancreas: 52.9412% (minimum 75%, Uncertain); parathyroid gland: 51.2195% (minimum 70%, Uncertain); pituitary gland: 53.8462% (minimum 75%, Missing); rectum: 68.1081% (minimum 70%, Missing); retina: 60.8696% (minimum 75%, Missing); salivary gland: 56.0000% (minimum 70%, Missing); skeletal muscle: 56.5022% (minimum 75%, Uncertain); skin: 48.4615% (minimum 65%, Missing); small intestine: 57.7982% (minimum 75%, Missing); smooth muscle: 64.2857% (minimum 75%, Missing); spinal cord: 70.3911% (minimum 75%, Missing); spleen: 52.5000% (minimum 65%, Uncertain); stomach: 58.8785% (minimum 70%, Missing); thymus: 56.0000% (minimum 65%, Missing); thyroid gland: 49.0272% (minimum 65%, Uncertain); tongue: 68.1081% (minimum 70%, Missing); urinary bladder: 55.2632% (minimum 70%, Uncertain)",-0.165385,-0.226316,-0.322881,0,1,partial,16.9,14,13.4,"liver: 16.9 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); lymph node: 14 nTPM (protected, limit 3); skin: 13.4 nTPM (manageable, limit 5); thyroid gland: 13.1 nTPM (manageable, limit 5); parathyroid gland: 12 nTPM (protected, limit 3); spleen: 11.4 nTPM (manageable, limit 5); pancreas: 11.2 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (manageable, limit 5); urinary bladder: 10.2 nTPM (protected, limit 3); salivary gland: 9.9 nTPM (protected, limit 3); thymus: 9.9 nTPM (manageable, limit 5); skeletal muscle: 9.7 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 3); lung: 9.5 nTPM (vital, limit 1); kidney: 9.3 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); adrenal gland: 9 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 3); colon: 8.8 nTPM (protected, limit 3); heart muscle: 8.7 nTPM (vital, limit 1); bone marrow: 8.7 nTPM (vital, limit 1); retina: 8.1 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 3); tongue: 5.9 nTPM (protected, limit 3); basal ganglia: 5.7 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,THADA,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000116183,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.188462,0,3,partial,6.1,1.5,0.6,"kidney: 6.1 nTPM (vital, limit 6); retina: 3.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PAPPA2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,"Bruggeman 2018;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000116191,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"retina: 57.1898% (minimum 75%, Missing)",0.0742456,0.0557441,-0.178102,0,7,partial,52.1,45.3,26.5,"retina: 52.1 nTPM (vital, limit 1); lymph node: 45.3 nTPM (protected, limit 12); liver: 28.8 nTPM (vital, limit 6); spleen: 26.5 nTPM (manageable, limit 5); skin: 18.7 nTPM (manageable, limit 5); esophagus: 17.3 nTPM (protected, limit 3); small intestine: 15.9 nTPM (vital, limit 1); thymus: 14.3 nTPM (manageable, limit 5); stomach: 13.5 nTPM (protected, limit 12); colon: 13.4 nTPM (protected, limit 3); urinary bladder: 12.3 nTPM (protected, limit 12); rectum: 12 nTPM (protected, limit 3); smooth muscle: 11 nTPM (vital, limit 6); duodenum: 10.7 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); adrenal gland: 8.7 nTPM (vital, limit 6); kidney: 6.2 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 3); heart muscle: 4.5 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RALGPS2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000116721,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRAMEF1,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000116726,False,excluded,positive_ihc_outside_permitted;unresolved_reproductive_selectivity;reviewed_unreliable_ihc,True,True,True,,,,,0,1,unreliable,0.1,0,0,,cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRAMEF12,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000116793,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 61.4583% (minimum 75%, Missing); cerebellum: 67.9724% (minimum 75%, Missing); choroid plexus: 51.1265% (minimum 75%, Missing); pituitary gland: 71.6019% (minimum 75%, Missing); retina: 68.2870% (minimum 75%, Missing)",0.128364,0.026601,-0.238735,0,80,unavailable,28.2,11.1,8.4,"choroid plexus: 28.2 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); cerebellum: 13.9 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 3); hypothalamus: 8.6 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); kidney: 8.4 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 3); smooth muscle: 6.4 nTPM (vital, limit 1); urinary bladder: 6.1 nTPM (protected, limit 3); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); midbrain: 5.8 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 3); heart muscle: 5.4 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); rectum: 4.7 nTPM (protected, limit 3); colon: 4.6 nTPM (protected, limit 3); skeletal muscle: 4.4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); small intestine: 3.9 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PHTF1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000116977,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 55.5000% (minimum 75%, Missing); duodenum: 72.5490% (minimum 75%, Missing); heart muscle: 51.1521% (minimum 75%, Missing); kidney: 70.9719% (minimum 75%, Missing); liver: 53.6750% (minimum 75%, Missing); lung: 67.9315% (minimum 75%, Missing); pancreas: 72.4543% (minimum 75%, Missing); parathyroid gland: 62.0805% (minimum 70%, Missing); retina: 71.4286% (minimum 75%, Missing); skin: 63.7931% (minimum 65%, Missing); small intestine: 70.3422% (minimum 75%, Missing); spleen: 57.1576% (minimum 65%, Missing); urinary bladder: 63.7199% (minimum 70%, Missing)",-0.0784243,-0.0791946,-0.238479,0,4,partial,53,33.9,41.6,"heart muscle: 53 nTPM (vital, limit 1); liver: 47.9 nTPM (vital, limit 1); bone marrow: 44.5 nTPM (vital, limit 1); spleen: 41.6 nTPM (manageable, limit 5); parathyroid gland: 33.9 nTPM (protected, limit 3); urinary bladder: 31.6 nTPM (protected, limit 3); skin: 31.5 nTPM (manageable, limit 5); adipose tissue: 27.6 nTPM (manageable, limit 5); lung: 26.2 nTPM (vital, limit 1); thymus: 25.7 nTPM (manageable, limit 5); small intestine: 23.4 nTPM (vital, limit 1); lymph node: 23.4 nTPM (protected, limit 3); kidney: 22.7 nTPM (vital, limit 1); retina: 22.2 nTPM (vital, limit 1); salivary gland: 21.5 nTPM (protected, limit 3); smooth muscle: 21.1 nTPM (vital, limit 2); pancreas: 21.1 nTPM (vital, limit 1); duodenum: 21 nTPM (vital, limit 1); esophagus: 20.5 nTPM (protected, limit 3); colon: 19.3 nTPM (protected, limit 3); rectum: 19.3 nTPM (protected, limit 3); stomach: 18.4 nTPM (protected, limit 3); cerebellum: 17.1 nTPM (vital, limit 1); thyroid gland: 16.7 nTPM (manageable, limit 5); cerebral cortex: 15.8 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); spinal cord: 14.2 nTPM (vital, limit 1); adrenal gland: 13.8 nTPM (vital, limit 1); hippocampal formation: 12.6 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); amygdala: 11.2 nTPM (vital, limit 1); midbrain: 11 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 3); skeletal muscle: 6.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LGALS8,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000117148,True,compatible,,True,True,True,,0.35,0.271831,0.235714,0,80,unavailable,0.1,0.2,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ACTL8,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,True,True,True,True,gained,selectivity_revised
ENSG00000117155,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 70.9544% (minimum 75%, Missing); retina: 47.1291% (minimum 75%, Missing)",0.247638,0.220179,-0.278709,0,10,partial,115.1,8.9,11.7,"retina: 115.1 nTPM (vital, limit 1); duodenum: 42 nTPM (vital, limit 1); cerebral cortex: 27.1 nTPM (vital, limit 1); small intestine: 26.1 nTPM (vital, limit 1); cerebellum: 20.4 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); bone marrow: 14.7 nTPM (vital, limit 1); basal ganglia: 14.6 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 1); thymus: 11.7 nTPM (manageable, limit 5); hippocampal formation: 10.4 nTPM (vital, limit 1); smooth muscle: 10.3 nTPM (vital, limit 1); pituitary gland: 9.3 nTPM (vital, limit 1); heart muscle: 9.1 nTPM (vital, limit 1); parathyroid gland: 8.9 nTPM (protected, limit 3); amygdala: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); colon: 7.9 nTPM (protected, limit 3); rectum: 7.6 nTPM (protected, limit 3); stomach: 6.9 nTPM (protected, limit 3); pancreas: 6.9 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 3); choroid plexus: 6.6 nTPM (vital, limit 1); skin: 6.3 nTPM (manageable, limit 5); lymph node: 6.2 nTPM (protected, limit 3); esophagus: 6.2 nTPM (protected, limit 3); urinary bladder: 5.5 nTPM (protected, limit 3); hypothalamus: 5.4 nTPM (vital, limit 1); spleen: 5.2 nTPM (manageable, limit 5); lung: 3.7 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 3); midbrain: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skin 1 / arrector pili muscle cells: Low (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Low (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Low (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / arrector pili muscle cells; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SSX2IP,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000117400,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 54.0541% (minimum 75%, Missing); cerebral cortex: 71.4286% (minimum 75%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); pancreas: 74.0741% (minimum 75%, Missing); retina: 57.1429% (minimum 75%, Missing); smooth muscle: 74.0741% (minimum 75%, Missing)",0.0396552,0.1,-0.209459,0,80,unavailable,1.7,0.5,0.9,"bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MPL,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000117461,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.2949% (minimum 65%, Missing); adrenal gland: 69.6658% (minimum 75%, Missing); amygdala: 72.0745% (minimum 75%, Missing); basal ganglia: 73.8420% (minimum 75%, Missing); cerebellum: 37.4827% (minimum 75%, Missing); cerebral cortex: 70.2073% (minimum 75%, Missing); choroid plexus: 66.2592% (minimum 75%, Missing); heart muscle: 44.2088% (minimum 70%, Approved); hypothalamus: 69.6658% (minimum 75%, Missing); kidney: 63.3178% (minimum 75%, Missing); lung: 60.0887% (minimum 75%, Missing); midbrain: 70.0258% (minimum 75%, Missing); parathyroid gland: 69.8454% (minimum 70%, Missing); retina: 61.0360% (minimum 75%, Missing); salivary gland: 68.9567% (minimum 70%, Missing); tongue: 60.4911% (minimum 70%, Missing); urinary bladder: 65.4589% (minimum 70%, Missing)",-0.177051,-0.0950893,-0.375173,0,4,partial,45.2,17.7,30.2,"cerebellum: 45.2 nTPM (vital, limit 1); heart muscle: 34.2 nTPM (vital, limit 2); adipose tissue: 30.2 nTPM (manageable, limit 5); lung: 18 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 3); retina: 17.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); urinary bladder: 14.3 nTPM (protected, limit 3); choroid plexus: 13.8 nTPM (vital, limit 1); thyroid gland: 13.8 nTPM (manageable, limit 5); salivary gland: 12.2 nTPM (protected, limit 3); adrenal gland: 11.8 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.7 nTPM (protected, limit 3); skeletal muscle: 11.6 nTPM (vital, limit 2); midbrain: 11.6 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); smooth muscle: 11.1 nTPM (vital, limit 2); spleen: 10.9 nTPM (manageable, limit 5); amygdala: 10.5 nTPM (vital, limit 1); thymus: 10.5 nTPM (manageable, limit 5); basal ganglia: 9.6 nTPM (vital, limit 1); stomach: 9.6 nTPM (protected, limit 3); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.5 nTPM (vital, limit 1); pituitary gland: 8.3 nTPM (vital, limit 1); small intestine: 8.3 nTPM (vital, limit 1); colon: 7.2 nTPM (protected, limit 3); esophagus: 6.9 nTPM (protected, limit 4); lymph node: 6.1 nTPM (protected, limit 3); skin: 6.1 nTPM (manageable, limit 5); rectum: 4.7 nTPM (protected, limit 3); pancreas: 4.5 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PIK3R3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000117475,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 72.8051% (minimum 75%, Missing); bone marrow: 57.5296% (minimum 75%, Missing); duodenum: 73.9130% (minimum 75%, Missing); esophagus: 52.0674% (minimum 70%, Missing); heart muscle: 68.8259% (minimum 75%, Missing); kidney: 67.4603% (minimum 75%, Missing); liver: 70.1031% (minimum 75%, Missing); lung: 73.1183% (minimum 75%, Missing); parathyroid gland: 69.9588% (minimum 70%, Missing); rectum: 69.3878% (minimum 70%, Missing); retina: 60.6061% (minimum 75%, Missing); small intestine: 73.4341% (minimum 75%, Missing); smooth muscle: 66.4062% (minimum 75%, Missing); urinary bladder: 68.0000% (minimum 70%, Missing)",0.00259117,-0.179326,-0.174704,0,5,partial,25.1,31.3,18.1,"esophagus: 31.3 nTPM (protected, limit 3); bone marrow: 25.1 nTPM (vital, limit 1); retina: 22.1 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (manageable, limit 5); skin: 17.4 nTPM (manageable, limit 5); smooth muscle: 17.2 nTPM (vital, limit 1); kidney: 16.4 nTPM (vital, limit 1); urinary bladder: 16 nTPM (protected, limit 3); heart muscle: 15.4 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 3); parathyroid gland: 14.6 nTPM (protected, limit 3); liver: 14.5 nTPM (vital, limit 1); thymus: 13.4 nTPM (manageable, limit 5); colon: 13.4 nTPM (protected, limit 3); stomach: 12.7 nTPM (protected, limit 3); adrenal gland: 12.7 nTPM (vital, limit 1); lung: 12.5 nTPM (vital, limit 1); salivary gland: 12.3 nTPM (protected, limit 3); small intestine: 12.3 nTPM (vital, limit 1); spleen: 12.1 nTPM (manageable, limit 5); duodenum: 12 nTPM (vital, limit 1); lymph node: 11.5 nTPM (protected, limit 3); skeletal muscle: 10.8 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 3); cerebral cortex: 9.9 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1); choroid plexus: 8 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); amygdala: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BLZF1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000117477,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 44.7368% (minimum 75%, Missing); hypothalamus: 69.6721% (minimum 75%, Missing); pituitary gland: 59.1647% (minimum 75%, Missing); retina: 39.7196% (minimum 75%, Missing)",0.338372,0.144823,-0.352804,0,6,partial,38.7,11.2,0.5,"retina: 38.7 nTPM (vital, limit 1); choroid plexus: 31.5 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); hypothalamus: 11.1 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 6); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.7 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC181,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000117569,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.6622% (minimum 65%, Uncertain); adrenal gland: 74.9186% (minimum 75%, Uncertain); amygdala: 57.6441% (minimum 75%, Missing); basal ganglia: 60.5263% (minimum 75%, Missing); bone marrow: 66.8605% (minimum 75%, Uncertain); cerebellum: 54.7619% (minimum 75%, Uncertain); cerebral cortex: 59.1260% (minimum 75%, Uncertain); colon: 41.5913% (minimum 70%, Uncertain); hippocampal formation: 54.8926% (minimum 75%, Missing); hypothalamus: 55.2885% (minimum 75%, Missing); kidney: 68.8623% (minimum 75%, Uncertain); lung: 73.2484% (minimum 75%, Uncertain); midbrain: 55.2885% (minimum 75%, Missing); pituitary gland: 67.4487% (minimum 75%, Missing); retina: 63.7119% (minimum 75%, Missing); skeletal muscle: 67.8466% (minimum 75%, Uncertain); small intestine: 64.7887% (minimum 75%, Uncertain); smooth muscle: 64.6067% (minimum 75%, Uncertain); spinal cord: 53.1178% (minimum 75%, Missing); stomach: 66.0920% (minimum 70%, Uncertain); urinary bladder: 57.6441% (minimum 70%, Uncertain)",-0.033378,-0.284087,-0.218822,0,1,partial,20.3,32.3,14.3,"colon: 32.3 nTPM (protected, limit 3); spinal cord: 20.3 nTPM (vital, limit 1); cerebellum: 19 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); midbrain: 18.6 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); urinary bladder: 16.9 nTPM (protected, limit 3); amygdala: 16.9 nTPM (vital, limit 1); cerebral cortex: 15.9 nTPM (vital, limit 1); basal ganglia: 15 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (manageable, limit 5); retina: 13.1 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 3); thyroid gland: 11.6 nTPM (manageable, limit 5); bone marrow: 11.4 nTPM (vital, limit 1); spleen: 11.2 nTPM (manageable, limit 5); pituitary gland: 11.1 nTPM (vital, limit 1); skeletal muscle: 10.9 nTPM (vital, limit 1); kidney: 10.4 nTPM (vital, limit 1); thymus: 10.2 nTPM (manageable, limit 5); tongue: 8.6 nTPM (protected, limit 3); lung: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); salivary gland: 8 nTPM (protected, limit 3); adrenal gland: 7.7 nTPM (vital, limit 1); esophagus: 7.7 nTPM (protected, limit 3); heart muscle: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 3); lymph node: 5.8 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",esophagus / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PTBP2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000117586,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing); lymph node: 63.3333% (minimum 70%, Missing); pituitary gland: 71.6981% (minimum 75%, Missing); retina: 74.5098% (minimum 75%, Missing); thymus: 51.3514% (minimum 65%, Missing)",-0.136486,-0.0666667,-0.0833333,0,5,partial,1.9,2.2,3.6,"adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TNFSF4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000117650,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.127116,0.181081,0.156815,0,2,partial,17.5,8.8,18.7,"thymus: 18.7 nTPM (manageable, limit 5); bone marrow: 17.5 nTPM (vital, limit 6); lymph node: 8.8 nTPM (protected, limit 3); rectum: 7.4 nTPM (protected, limit 3); duodenum: 7.2 nTPM (vital, limit 6); small intestine: 6.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NEK2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000117868,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6430% (minimum 60%, Approved); adrenal gland: 58.2500% (minimum 75%, Missing); basal ganglia: 70.4992% (minimum 75%, Missing); bone marrow: 61.3966% (minimum 70%, Approved); cerebellum: 67.3410% (minimum 75%, Missing); cerebral cortex: 70.9285% (minimum 75%, Missing); choroid plexus: 74.0859% (minimum 75%, Missing); colon: 55.6750% (minimum 70%, Missing); duodenum: 69.3452% (minimum 75%, Missing); esophagus: 54.2491% (minimum 65%, Approved); heart muscle: 58.1047% (minimum 70%, Approved); hippocampal formation: 72.4728% (minimum 75%, Missing); hypothalamus: 71.4724% (minimum 75%, Missing); kidney: 64.9930% (minimum 75%, Missing); liver: 67.6343% (minimum 75%, Missing); lung: 59.9743% (minimum 75%, Missing); lymph node: 64.4537% (minimum 70%, Missing); midbrain: 73.8510% (minimum 75%, Missing); pancreas: 64.9930% (minimum 75%, Missing); parathyroid gland: 61.0747% (minimum 70%, Missing); pituitary gland: 69.9700% (minimum 75%, Missing); rectum: 63.4014% (minimum 70%, Missing); salivary gland: 59.8972% (minimum 70%, Missing); skeletal muscle: 51.8354% (minimum 70%, Approved); skin: 60.8355% (minimum 65%, Missing); small intestine: 65.4494% (minimum 75%, Missing); smooth muscle: 57.1779% (minimum 70%, Approved); spinal cord: 74.6795% (minimum 75%, Missing); stomach: 67.8311% (minimum 70%, Missing); thymus: 57.2482% (minimum 65%, Missing); thyroid gland: 55.5423% (minimum 65%, Missing); tongue: 53.6866% (minimum 70%, Missing); urinary bladder: 58.0324% (minimum 70%, Missing)",-0.11357,-0.163134,-0.181646,0,2,partial,43.3,40.2,49.2,"adipose tissue: 49.2 nTPM (manageable, limit 10); skeletal muscle: 43.3 nTPM (vital, limit 2); tongue: 40.2 nTPM (protected, limit 3); esophagus: 39.3 nTPM (protected, limit 4); thyroid gland: 37.3 nTPM (manageable, limit 5); colon: 37.1 nTPM (protected, limit 3); smooth muscle: 34.9 nTPM (vital, limit 2); thymus: 34.8 nTPM (manageable, limit 5); urinary bladder: 33.7 nTPM (protected, limit 3); heart muscle: 33.6 nTPM (vital, limit 2); adrenal gland: 33.4 nTPM (vital, limit 1); salivary gland: 31.2 nTPM (protected, limit 3); lung: 31.1 nTPM (vital, limit 1); skin: 30 nTPM (manageable, limit 5); parathyroid gland: 29.7 nTPM (protected, limit 3); bone marrow: 29.3 nTPM (vital, limit 2); rectum: 26.9 nTPM (protected, limit 3); lymph node: 25.7 nTPM (protected, limit 3); kidney: 25.1 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); small intestine: 24.6 nTPM (vital, limit 1); cerebellum: 22.6 nTPM (vital, limit 1); liver: 22.3 nTPM (vital, limit 1); stomach: 22.1 nTPM (protected, limit 3); duodenum: 20.6 nTPM (vital, limit 1); spleen: 20.2 nTPM (manageable, limit 10); pituitary gland: 20 nTPM (vital, limit 1); basal ganglia: 19.5 nTPM (vital, limit 1); cerebral cortex: 19.1 nTPM (vital, limit 1); hypothalamus: 18.6 nTPM (vital, limit 1); hippocampal formation: 17.7 nTPM (vital, limit 1); midbrain: 16.5 nTPM (vital, limit 1); choroid plexus: 16.3 nTPM (vital, limit 1); spinal cord: 15.8 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); retina: 13.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ESYT2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000117971,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.0000% (minimum 75%, Missing); retina: 67.4699% (minimum 75%, Missing)",0.00882353,0.148485,-0.0753012,0,80,unavailable,2.7,1,2.9,"retina: 2.7 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CHRNB4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734,Bruggeman 2018;Loriot 2025 · preferential,False,False,False,False,False,unchanged,
ENSG00000118156,True,compatible,,True,True,True,,0.345215,0.295215,0.221963,0,2,partial,3,0.7,1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF541,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,False,gained,selectivity_revised
ENSG00000118193,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 26.9663% (minimum 75%, Missing); duodenum: 66.6667% (minimum 75%, Missing); lymph node: 43.6364% (minimum 70%, Missing); rectum: 66.6667% (minimum 70%, Missing); small intestine: 70.5882% (minimum 75%, Missing); thymus: 18.4615% (minimum 65%, Missing)",-0.465385,-0.263636,-0.480337,0,80,unavailable,6.5,3.1,10.6,"thymus: 10.6 nTPM (manageable, limit 5); bone marrow: 6.5 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 3); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KIF14,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000118245,True,compatible,,True,True,True,,0.35,0.3,0.249862,0,4,partial,2.3,1,2.3,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TNP1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,False,unchanged,
ENSG00000118307,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 61.6022% (minimum 75%, Missing)",0.197909,0.3,-0.133978,0,7,partial,13.9,3.2,4,"choroid plexus: 13.9 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAI7,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000118420,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.6056% (minimum 75%, Missing); amygdala: 72.7273% (minimum 75%, Missing); basal ganglia: 64.8649% (minimum 75%, Missing); cerebellum: 67.6056% (minimum 75%, Missing); cerebral cortex: 63.1579% (minimum 75%, Missing); duodenum: 69.5652% (minimum 75%, Missing); hippocampal formation: 73.8462% (minimum 75%, Missing); hypothalamus: 64.0000% (minimum 75%, Missing); kidney: 69.5652% (minimum 75%, Missing); midbrain: 69.5652% (minimum 75%, Missing); pancreas: 68.5714% (minimum 75%, Missing); pituitary gland: 67.6056% (minimum 75%, Missing); retina: 59.2593% (minimum 75%, Missing); skeletal muscle: 64.8649% (minimum 75%, Missing); spinal cord: 72.7273% (minimum 75%, Missing); thyroid gland: 64.8649% (minimum 65%, Missing); tongue: 66.6667% (minimum 70%, Missing)",-0.00135135,-0.0333333,-0.157407,0,3,partial,3.3,2.4,2.6,"retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,UBE3D,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000118434,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPACA1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000118491,True,compatible,,True,True,True,,0.336301,0.293103,0.236301,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZC2HC1B,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,True,True,True,True,gained,selectivity_revised
ENSG00000118492,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.288327,0.0910596,0,5,partial,4.8,0.3,0,"choroid plexus: 4.8 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ADGB,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000118596,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 16.8103% (minimum 65%, Missing); adrenal gland: 37.1429% (minimum 75%, Missing); bone marrow: 45.8824% (minimum 75%, Missing); cerebellum: 61.9048% (minimum 75%, Missing); cerebral cortex: 59.0909% (minimum 75%, Missing); colon: 66.1017% (minimum 70%, Missing); duodenum: 72.2222% (minimum 75%, Missing); esophagus: 38.6139% (minimum 65%, Approved); heart muscle: 10.5121% (minimum 70%, Approved); kidney: 25.8278% (minimum 75%, Missing); liver: 50.6494% (minimum 70%, Approved); lung: 47.5610% (minimum 75%, Missing); lymph node: 44.8276% (minimum 65%, Approved); pancreas: 29.3233% (minimum 75%, Missing); pituitary gland: 73.5849% (minimum 75%, Missing); rectum: 61.9048% (minimum 70%, Missing); retina: 69.6429% (minimum 75%, Missing); salivary gland: 59.0909% (minimum 70%, Missing); skeletal muscle: 68.4211% (minimum 75%, Missing); skin: 33.9130% (minimum 60%, Approved); small intestine: 61.9048% (minimum 70%, Approved); smooth muscle: 53.4247% (minimum 70%, Approved); spinal cord: 70.9091% (minimum 75%, Missing); spleen: 39.0000% (minimum 60%, Approved); stomach: 28.6765% (minimum 70%, Missing); thymus: 46.9880% (minimum 65%, Missing); tongue: 53.4247% (minimum 70%, Missing); urinary bladder: 50.6494% (minimum 70%, Missing)",-0.481897,-0.413235,-0.594879,0,7,partial,33.2,9.7,19.3,"heart muscle: 33.2 nTPM (vital, limit 2); adipose tissue: 19.3 nTPM (manageable, limit 5); kidney: 11.2 nTPM (vital, limit 1); stomach: 9.7 nTPM (protected, limit 3); pancreas: 9.4 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 4); lymph node: 4.8 nTPM (protected, limit 4); bone marrow: 4.6 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 2); urinary bladder: 3.8 nTPM (protected, limit 3); smooth muscle: 3.4 nTPM (vital, limit 2); tongue: 3.4 nTPM (protected, limit 3); cerebral cortex: 2.7 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC16A7,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000118620,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 48.2143% (minimum 75%, Missing); cerebellum: 72.4832% (minimum 75%, Missing); cerebral cortex: 74.4828% (minimum 75%, Missing); esophagus: 62.0690% (minimum 70%, Missing); lymph node: 51.6746% (minimum 70%, Missing); pancreas: 72.9730% (minimum 75%, Missing); parathyroid gland: 59.0164% (minimum 70%, Missing); skin: 60.0000% (minimum 65%, Missing); spleen: 62.7907% (minimum 65%, Missing); stomach: 69.2308% (minimum 70%, Missing); thymus: 53.2020% (minimum 65%, Missing); thyroid gland: 56.8421% (minimum 65%, Missing)",-0.11798,-0.183254,-0.267857,0,80,unavailable,11.6,10.1,9.5,"bone marrow: 11.6 nTPM (vital, limit 1); lymph node: 10.1 nTPM (protected, limit 3); thymus: 9.5 nTPM (manageable, limit 5); thyroid gland: 8.2 nTPM (manageable, limit 5); parathyroid gland: 7.5 nTPM (protected, limit 3); skin: 7.2 nTPM (manageable, limit 5); esophagus: 6.6 nTPM (protected, limit 3); spleen: 6.4 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 3); urinary bladder: 4.4 nTPM (protected, limit 3); cerebellum: 4.1 nTPM (vital, limit 1); rectum: 4.1 nTPM (protected, limit 3); pancreas: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 3); smooth muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF430,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000118965,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.1824% (minimum 70%, Approved); basal ganglia: 70.9677% (minimum 75%, Missing); cerebral cortex: 68.7500% (minimum 75%, Missing); choroid plexus: 45.6432% (minimum 75%, Missing); hypothalamus: 70.5128% (minimum 75%, Missing); kidney: 59.1398% (minimum 75%, Missing); lung: 71.8954% (minimum 75%, Missing); midbrain: 74.8299% (minimum 75%, Missing); pancreas: 74.8299% (minimum 75%, Missing); parathyroid gland: 44.1767% (minimum 70%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); retina: 47.4138% (minimum 75%, Missing); smooth muscle: 64.7059% (minimum 70%, Approved); thyroid gland: 56.4103% (minimum 65%, Missing)",-0.0858974,-0.258233,-0.293568,0,6,partial,13.1,13.9,8.5,"parathyroid gland: 13.9 nTPM (protected, limit 3); choroid plexus: 13.1 nTPM (vital, limit 1); retina: 12.2 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); kidney: 7.6 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 2); cerebral cortex: 5 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 2); colon: 4.7 nTPM (protected, limit 3); hypothalamus: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 4); midbrain: 3.7 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); heart muscle: 3.2 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 2); cerebellum: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,WDR35,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000118997,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 66.0377% (minimum 75%, Missing); basal ganglia: 55.2632% (minimum 75%, Missing); choroid plexus: 33.9806% (minimum 75%, Missing); hippocampal formation: 69.5364% (minimum 75%, Missing); hypothalamus: 69.0789% (minimum 75%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 54.6875% (minimum 75%, Missing)",0.122059,0.245946,-0.410194,0,6,partial,20.4,1.9,3.1,"choroid plexus: 20.4 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 6); amygdala: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAH7,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000119231,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 74.8148% (minimum 75%, Missing); amygdala: 67.5585% (minimum 75%, Missing); basal ganglia: 68.4746% (minimum 75%, Missing); bone marrow: 56.4246% (minimum 75%, Missing); cerebellum: 56.5826% (minimum 75%, Missing); cerebral cortex: 63.7224% (minimum 75%, Missing); colon: 67.1096% (minimum 70%, Missing); heart muscle: 69.1781% (minimum 75%, Missing); hippocampal formation: 65.1613% (minimum 75%, Missing); hypothalamus: 62.5387% (minimum 75%, Missing); kidney: 72.6619% (minimum 75%, Missing); liver: 67.3333% (minimum 75%, Missing); lung: 67.7852% (minimum 75%, Missing); lymph node: 69.6552% (minimum 70%, Missing); midbrain: 65.3722% (minimum 75%, Missing); pancreas: 72.1429% (minimum 75%, Missing); pituitary gland: 66.8874% (minimum 75%, Missing); retina: 54.4474% (minimum 75%, Missing); skeletal muscle: 63.9241% (minimum 75%, Missing); small intestine: 71.3781% (minimum 75%, Missing); smooth muscle: 72.6619% (minimum 75%, Missing); spinal cord: 65.5844% (minimum 75%, Missing); tongue: 63.3229% (minimum 70%, Missing); urinary bladder: 69.8962% (minimum 70%, Missing)",0.0122951,-0.0667712,-0.205526,0,80,unavailable,16.9,11.7,10.3,"retina: 16.9 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); cerebellum: 15.5 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); tongue: 11.7 nTPM (protected, limit 3); cerebral cortex: 11.5 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); thymus: 10.3 nTPM (manageable, limit 5); spleen: 10.2 nTPM (manageable, limit 5); pituitary gland: 10 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 3); liver: 9.8 nTPM (vital, limit 1); amygdala: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 9.3 nTPM (vital, limit 1); skin: 9.1 nTPM (manageable, limit 5); heart muscle: 9 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 3); urinary bladder: 8.7 nTPM (protected, limit 3); parathyroid gland: 8.5 nTPM (protected, limit 3); esophagus: 8.2 nTPM (protected, limit 3); small intestine: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); stomach: 8 nTPM (protected, limit 3); pancreas: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (manageable, limit 5); smooth muscle: 7.6 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 1); salivary gland: 7.5 nTPM (protected, limit 3); adrenal gland: 6.8 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); choroid plexus: 6.7 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SENP5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000119547,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 50.0000% (minimum 60%, Enhanced); basal ganglia: 2.9412% (minimum 75%, Missing); cerebellum: 12.5000% (minimum 60%, Enhanced); cerebral cortex: 20.0000% (minimum 60%, Enhanced); duodenum: 1.0000% (minimum 60%, Enhanced); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 25.0000% (minimum 75%, Missing); kidney: 50.0000% (minimum 60%, Enhanced); liver: 1.2048% (minimum 60%, Enhanced); pancreas: 4.1667% (minimum 60%, Enhanced); parathyroid gland: 11.1111% (minimum 55%, Enhanced); pituitary gland: 11.1111% (minimum 75%, Missing); retina: 1.8519% (minimum 75%, Missing); small intestine: 4.5455% (minimum 75%, Missing); stomach: 50.0000% (minimum 55%, Enhanced)",0.35,-0.438889,-0.731481,0,3,partial,9.9,0.8,0,"duodenum: 9.9 nTPM (vital, limit 6); liver: 8.2 nTPM (vital, limit 6); retina: 5.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Enhanced),52,not_established,required,in_situ_inflammation_review,gallbladder; gallbladder / glandular cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ONECUT2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000119559,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 48.5327% (minimum 70%, Approved); amygdala: 33.9652% (minimum 75%, Missing); basal ganglia: 37.0690% (minimum 75%, Missing); cerebellum: 43.1727% (minimum 70%, Approved); cerebral cortex: 33.6991% (minimum 70%, Approved); choroid plexus: 54.2929% (minimum 75%, Missing); colon: 55.2699% (minimum 70%, Missing); duodenum: 58.7432% (minimum 75%, Missing); esophagus: 52.0581% (minimum 70%, Missing); heart muscle: 51.0689% (minimum 75%, Missing); hippocampal formation: 35.1307% (minimum 75%, Missing); hypothalamus: 38.1206% (minimum 75%, Missing); kidney: 41.6667% (minimum 75%, Missing); liver: 42.8287% (minimum 75%, Missing); lung: 60.0559% (minimum 70%, Approved); lymph node: 59.7222% (minimum 65%, Approved); midbrain: 35.3038% (minimum 75%, Missing); pancreas: 52.5672% (minimum 70%, Approved); parathyroid gland: 58.9041% (minimum 70%, Missing); pituitary gland: 44.8852% (minimum 75%, Missing); salivary gland: 55.6995% (minimum 70%, Missing); skeletal muscle: 57.9515% (minimum 70%, Approved); skin: 56.1358% (minimum 65%, Missing); small intestine: 55.5556% (minimum 75%, Missing); spinal cord: 35.8932% (minimum 75%, Missing); spleen: 48.5327% (minimum 60%, Approved); stomach: 55.4124% (minimum 70%, Missing); thyroid gland: 48.2063% (minimum 65%, Missing); urinary bladder: 55.9896% (minimum 70%, Missing)",-0.167937,-0.179419,-0.410348,0,4,partial,42.3,19.8,23.1,"cerebral cortex: 42.3 nTPM (vital, limit 2); amygdala: 41.8 nTPM (vital, limit 1); hippocampal formation: 39.7 nTPM (vital, limit 1); midbrain: 39.4 nTPM (vital, limit 1); spinal cord: 38.4 nTPM (vital, limit 1); basal ganglia: 36.5 nTPM (vital, limit 1); hypothalamus: 34.9 nTPM (vital, limit 1); kidney: 30.1 nTPM (vital, limit 1); liver: 28.7 nTPM (vital, limit 1); cerebellum: 28.3 nTPM (vital, limit 2); pituitary gland: 26.4 nTPM (vital, limit 1); thyroid gland: 23.1 nTPM (manageable, limit 5); spleen: 22.8 nTPM (manageable, limit 10); adrenal gland: 22.8 nTPM (vital, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); esophagus: 19.8 nTPM (protected, limit 3); pancreas: 19.4 nTPM (vital, limit 2); choroid plexus: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 3); stomach: 17.3 nTPM (protected, limit 3); small intestine: 17.2 nTPM (vital, limit 1); salivary gland: 17.1 nTPM (protected, limit 3); urinary bladder: 16.9 nTPM (protected, limit 3); skin: 16.8 nTPM (manageable, limit 5); skeletal muscle: 15.6 nTPM (vital, limit 2); duodenum: 15.1 nTPM (vital, limit 1); parathyroid gland: 15 nTPM (protected, limit 3); lymph node: 14.5 nTPM (protected, limit 4); lung: 14.3 nTPM (vital, limit 2); adipose tissue: 13.9 nTPM (manageable, limit 10); thymus: 9.2 nTPM (manageable, limit 5); bone marrow: 7.7 nTPM (vital, limit 2); tongue: 7.2 nTPM (protected, limit 3); retina: 6.7 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 2); rectum: 4.9 nTPM (protected, limit 3)",bronchus / respiratory epithelial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C19orf25,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000119661,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.122595,0.0910448,0.00391181,0,6,partial,17.3,14,15.6,"retina: 17.3 nTPM (vital, limit 1); thyroid gland: 15.6 nTPM (manageable, limit 5); choroid plexus: 15.1 nTPM (vital, limit 1); parathyroid gland: 14 nTPM (protected, limit 3); cerebral cortex: 11 nTPM (vital, limit 1); kidney: 10.8 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 2); heart muscle: 8.7 nTPM (vital, limit 1); pituitary gland: 8.2 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (manageable, limit 5); lung: 7.1 nTPM (vital, limit 2); amygdala: 6.9 nTPM (vital, limit 1); adrenal gland: 6 nTPM (vital, limit 2); urinary bladder: 5.9 nTPM (protected, limit 3); thymus: 5.8 nTPM (manageable, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 3); pancreas: 5.5 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); cerebellum: 5.1 nTPM (vital, limit 2); bone marrow: 5.1 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 3); skeletal muscle: 4.8 nTPM (vital, limit 2); spinal cord: 4.7 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); colon: 4.5 nTPM (protected, limit 4); salivary gland: 4.3 nTPM (protected, limit 3); esophagus: 4.2 nTPM (protected, limit 4); liver: 3.5 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 2); duodenum: 2.6 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000119703,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.310644,0.253819,0.113344,0,6,partial,8.5,6.7,6.8,"choroid plexus: 8.5 nTPM (vital, limit 1); liver: 8.2 nTPM (vital, limit 6); pituitary gland: 6 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hypothalamus: 3.8 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZC2HC1C,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000119725,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.9484% (minimum 65%, Missing); adrenal gland: 57.7279% (minimum 75%, Missing); amygdala: 71.9934% (minimum 75%, Missing); basal ganglia: 71.8750% (minimum 75%, Missing); bone marrow: 43.3962% (minimum 75%, Missing); cerebellum: 72.1122% (minimum 75%, Missing); cerebral cortex: 71.9934% (minimum 75%, Missing); choroid plexus: 58.7366% (minimum 75%, Missing); colon: 59.6995% (minimum 70%, Missing); duodenum: 70.2572% (minimum 75%, Missing); esophagus: 57.4244% (minimum 70%, Missing); heart muscle: 68.3881% (minimum 75%, Missing); hippocampal formation: 73.3221% (minimum 75%, Missing); hypothalamus: 73.4454% (minimum 75%, Missing); kidney: 57.7279% (minimum 75%, Missing); liver: 60.9484% (minimum 75%, Missing); lung: 62.0739% (minimum 75%, Missing); lymph node: 63.5174% (minimum 70%, Missing); midbrain: 71.1726% (minimum 75%, Missing); pancreas: 68.6028% (minimum 75%, Missing); parathyroid gland: 62.6973% (minimum 70%, Missing); pituitary gland: 62.5179% (minimum 75%, Missing); rectum: 65.1267% (minimum 70%, Missing); retina: 66.5145% (minimum 75%, Missing); salivary gland: 64.8368% (minimum 70%, Missing); skeletal muscle: 68.2812% (minimum 75%, Missing); skin: 54.5568% (minimum 65%, Missing); small intestine: 64.0762% (minimum 75%, Missing); smooth muscle: 62.0739% (minimum 75%, Missing); spinal cord: 70.4839% (minimum 75%, Missing); spleen: 63.1503% (minimum 65%, Missing); stomach: 63.7026% (minimum 70%, Missing); thymus: 60.1928% (minimum 65%, Missing); thyroid gland: 64.7407% (minimum 65%, Missing); urinary bladder: 60.8635% (minimum 70%, Missing)",-0.104432,-0.125756,-0.316038,0,80,unavailable,57,32.4,36.4,"bone marrow: 57 nTPM (vital, limit 1); skin: 36.4 nTPM (manageable, limit 5); esophagus: 32.4 nTPM (protected, limit 3); adrenal gland: 32 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); colon: 29.5 nTPM (protected, limit 3); thymus: 28.9 nTPM (manageable, limit 5); urinary bladder: 28.1 nTPM (protected, limit 3); liver: 28 nTPM (vital, limit 1); adipose tissue: 28 nTPM (manageable, limit 5); lung: 26.7 nTPM (vital, limit 1); smooth muscle: 26.7 nTPM (vital, limit 1); pituitary gland: 26.2 nTPM (vital, limit 1); parathyroid gland: 26 nTPM (protected, limit 3); spleen: 25.5 nTPM (manageable, limit 5); lymph node: 25.1 nTPM (protected, limit 3); stomach: 24.9 nTPM (protected, limit 3); small intestine: 24.5 nTPM (vital, limit 1); thyroid gland: 23.8 nTPM (manageable, limit 5); salivary gland: 23.7 nTPM (protected, limit 3); rectum: 23.4 nTPM (protected, limit 3); retina: 22 nTPM (vital, limit 1); skeletal muscle: 20.3 nTPM (vital, limit 1); heart muscle: 20.2 nTPM (vital, limit 1); pancreas: 20 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); spinal cord: 18.3 nTPM (vital, limit 1); tongue: 17.7 nTPM (protected, limit 3); midbrain: 17.7 nTPM (vital, limit 1); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 17 nTPM (vital, limit 1); amygdala: 17 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); hippocampal formation: 15.9 nTPM (vital, limit 1); hypothalamus: 15.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF410,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000120051,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342366,0.248905,0.0524691,0,2,partial,3.2,0.7,0.7,"choroid plexus: 3.2 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 2); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP58,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000120160,True,compatible,,True,True,True,,0.35,0.297283,0.233914,0,2,partial,0.6,0.3,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EQTN,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000120210,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 69.2308% (minimum 75%, Missing)",0.35,0.3,-0.0576923,0,4,partial,6.4,1,1.1,"retina: 6.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,INSL6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000120211,True,compatible,,True,True,True,,0.337179,0.293548,0.230892,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,INSL4,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,True,True,True,True,gained,selectivity_revised
ENSG00000120215,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skin: 3.0162% (minimum 65%, Missing)",-0.619838,0.0152174,0.0147059,0,6,partial,0.7,1,41.8,"skin: 41.8 nTPM (manageable, limit 5)",retina / pigment epithelial cells: Medium (Enhanced),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / melanocytes; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MLANA,current_adaptive,True,False,False,False,10.1186/s12967-024-04918-0,Seager 2024 · panel,False,False,False,False,False,unchanged,
ENSG00000120262,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 73.9726% (minimum 75%, Missing)",0.207143,0.296923,-0.010274,0,7,partial,11.4,1.6,5.4,"choroid plexus: 11.4 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC170,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000120289,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEB4,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000120329,True,compatible,,True,True,True,,0.319697,0.284615,0.219697,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC25A2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000120334,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 50.2674% (minimum 75%, Missing); lymph node: 59.8726% (minimum 70%, Missing); thymus: 52.5140% (minimum 65%, Missing)",-0.12486,-0.101274,-0.247326,0,2,partial,9.3,6.3,8.5,"bone marrow: 9.3 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); lymph node: 6.3 nTPM (protected, limit 3); smooth muscle: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CENPL,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000120341,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.4118% (minimum 50%, Enhanced); colon: 51.2195% (minimum 70%, Missing); duodenum: 12.8049% (minimum 75%, Missing); kidney: 52.5000% (minimum 60%, Enhanced); liver: 9.5023% (minimum 60%, Enhanced); pancreas: 29.5775% (minimum 75%, Missing); rectum: 49.4118% (minimum 70%, Missing); retina: 39.2523% (minimum 75%, Missing); salivary gland: 54.5455% (minimum 55%, Enhanced); skeletal muscle: 31.5789% (minimum 60%, Enhanced); small intestine: 12.8834% (minimum 75%, Missing); smooth muscle: 58.3333% (minimum 60%, Enhanced); spleen: 40.7767% (minimum 50%, Enhanced); stomach: 31.8182% (minimum 55%, Enhanced); tongue: 56.7568% (minimum 70%, Missing)",-0.092233,-0.231818,-0.621951,0,7,partial,40,9,6.1,"liver: 40 nTPM (vital, limit 6); duodenum: 28.6 nTPM (vital, limit 1); small intestine: 28.4 nTPM (vital, limit 1); pancreas: 10 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 6); retina: 6.5 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 3); colon: 4 nTPM (protected, limit 3); tongue: 3.2 nTPM (protected, limit 3); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SEC16B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000120436,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 33.3333% (minimum 70%, Missing); spleen: 53.8462% (minimum 65%, Missing)",-0.111538,-0.366667,0.0277778,0,80,unavailable,0.2,1.4,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GPR31,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000120440,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333516,0.278142,0.167949,0,80,unavailable,1.6,0.4,0.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TTLL2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000120451,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.3407% (minimum 65%, Uncertain); adrenal gland: 53.6269% (minimum 75%, Missing); amygdala: 54.7619% (minimum 75%, Missing); basal ganglia: 52.4051% (minimum 75%, Missing); bone marrow: 70.6485% (minimum 75%, Uncertain); cerebellum: 60.5263% (minimum 75%, Missing); cerebral cortex: 56.4033% (minimum 75%, Missing); choroid plexus: 67.8689% (minimum 75%, Missing); colon: 49.0521% (minimum 70%, Missing); duodenum: 64.4860% (minimum 75%, Missing); esophagus: 59.1429% (minimum 70%, Uncertain); heart muscle: 51.4925% (minimum 75%, Missing); hippocampal formation: 54.4737% (minimum 75%, Missing); hypothalamus: 55.0532% (minimum 75%, Missing); kidney: 56.2500% (minimum 75%, Missing); liver: 52.4051% (minimum 75%, Missing); lung: 59.3123% (minimum 75%, Missing); lymph node: 65.9236% (minimum 70%, Uncertain); midbrain: 50.6112% (minimum 75%, Missing); pancreas: 52.2727% (minimum 75%, Missing); parathyroid gland: 57.1823% (minimum 70%, Missing); pituitary gland: 55.3476% (minimum 75%, Missing); rectum: 60.3499% (minimum 70%, Uncertain); retina: 57.9832% (minimum 75%, Missing); salivary gland: 52.2727% (minimum 70%, Uncertain); skeletal muscle: 47.3684% (minimum 75%, Missing); skin: 62.3494% (minimum 65%, Missing); small intestine: 57.9832% (minimum 75%, Missing); smooth muscle: 52.4051% (minimum 75%, Uncertain); spinal cord: 45.8980% (minimum 75%, Missing); spleen: 58.1461% (minimum 65%, Uncertain); stomach: 52.9412% (minimum 70%, Missing); thyroid gland: 49.7596% (minimum 65%, Missing); tongue: 61.9760% (minimum 70%, Missing); urinary bladder: 52.8061% (minimum 70%, Missing)",-0.152404,-0.209479,-0.29102,0,6,partial,24.4,21.5,20.9,"spinal cord: 24.4 nTPM (vital, limit 1); skeletal muscle: 23 nTPM (vital, limit 1); colon: 21.5 nTPM (protected, limit 3); thyroid gland: 20.9 nTPM (manageable, limit 5); midbrain: 20.2 nTPM (vital, limit 1); heart muscle: 19.5 nTPM (vital, limit 1); salivary gland: 18.9 nTPM (protected, limit 3); pancreas: 18.9 nTPM (vital, limit 1); basal ganglia: 18.8 nTPM (vital, limit 1); smooth muscle: 18.8 nTPM (vital, limit 1); liver: 18.8 nTPM (vital, limit 1); urinary bladder: 18.5 nTPM (protected, limit 3); stomach: 18.4 nTPM (protected, limit 3); adrenal gland: 17.9 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); amygdala: 17.1 nTPM (vital, limit 1); hypothalamus: 16.9 nTPM (vital, limit 1); pituitary gland: 16.7 nTPM (vital, limit 1); kidney: 16.1 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); parathyroid gland: 15.5 nTPM (protected, limit 3); adipose tissue: 15.4 nTPM (manageable, limit 5); retina: 15 nTPM (vital, limit 1); small intestine: 15 nTPM (vital, limit 1); spleen: 14.9 nTPM (manageable, limit 5); esophagus: 14.3 nTPM (protected, limit 3); lung: 14.2 nTPM (vital, limit 1); rectum: 13.6 nTPM (protected, limit 3); cerebellum: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 3); skin: 12.5 nTPM (manageable, limit 5); duodenum: 11.4 nTPM (vital, limit 1); thymus: 10.8 nTPM (manageable, limit 5); lymph node: 10.7 nTPM (protected, limit 3); choroid plexus: 9.8 nTPM (vital, limit 1); bone marrow: 8.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SNX19,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000120498,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 45.3815% (minimum 75%, Missing); pancreas: 16.5447% (minimum 70%, Approved)",0.32623,0.232812,-0.534553,0,1,partial,57,1.5,0.9,"pancreas: 57 nTPM (vital, limit 2); choroid plexus: 13.6 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX11,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000120519,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.0061% (minimum 75%, Missing); bone marrow: 66.8539% (minimum 75%, Missing); colon: 63.9785% (minimum 70%, Missing); duodenum: 72.5610% (minimum 75%, Missing); esophagus: 68.0000% (minimum 70%, Missing); liver: 62.9630% (minimum 75%, Missing); lung: 67.6136% (minimum 75%, Missing); lymph node: 68.7861% (minimum 70%, Missing); pancreas: 65.3846% (minimum 75%, Missing); rectum: 57.2115% (minimum 70%, Missing); salivary gland: 64.3243% (minimum 70%, Missing); small intestine: 69.1860% (minimum 75%, Missing); smooth muscle: 68.0000% (minimum 75%, Missing); stomach: 55.3488% (minimum 70%, Missing); thyroid gland: 63.9785% (minimum 65%, Missing)",-0.0102151,-0.146512,-0.12037,0,80,unavailable,7,9.6,6.7,"stomach: 9.6 nTPM (protected, limit 3); rectum: 8.9 nTPM (protected, limit 3); liver: 7 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (manageable, limit 5); colon: 6.7 nTPM (protected, limit 3); salivary gland: 6.6 nTPM (protected, limit 3); thymus: 6.3 nTPM (manageable, limit 5); pancreas: 6.3 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); smooth muscle: 5.6 nTPM (vital, limit 1); esophagus: 5.6 nTPM (protected, limit 3); lymph node: 5.4 nTPM (protected, limit 3); small intestine: 5.3 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); spleen: 5.2 nTPM (manageable, limit 5); urinary bladder: 4.5 nTPM (protected, limit 3); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); pituitary gland: 3.5 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); heart muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC10A7,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000120563,True,compatible,,True,True,True,,0.35,0.3,0.247988,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LYZL1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000120616,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.7101% (minimum 65%, Missing); adrenal gland: 68.8963% (minimum 75%, Missing); amygdala: 72.2807% (minimum 75%, Missing); basal ganglia: 70.7904% (minimum 75%, Missing); bone marrow: 12.2400% (minimum 75%, Missing); cerebellum: 49.0476% (minimum 75%, Missing); cerebral cortex: 68.2119% (minimum 75%, Missing); choroid plexus: 67.5410% (minimum 75%, Missing); colon: 57.2222% (minimum 70%, Missing); duodenum: 64.9842% (minimum 75%, Missing); esophagus: 65.6051% (minimum 70%, Missing); heart muscle: 64.1745% (minimum 75%, Missing); hippocampal formation: 71.2803% (minimum 75%, Missing); hypothalamus: 72.7915% (minimum 75%, Missing); kidney: 64.1745% (minimum 75%, Missing); liver: 60.5882% (minimum 75%, Missing); lung: 59.0258% (minimum 75%, Missing); lymph node: 49.5192% (minimum 70%, Missing); midbrain: 73.5714% (minimum 75%, Missing); pancreas: 59.7101% (minimum 75%, Missing); parathyroid gland: 59.3660% (minimum 70%, Missing); pituitary gland: 67.1010% (minimum 75%, Missing); rectum: 56.9061% (minimum 70%, Missing); retina: 52.4173% (minimum 75%, Missing); salivary gland: 58.5227% (minimum 70%, Missing); skeletal muscle: 48.4706% (minimum 75%, Missing); skin: 60.5882% (minimum 65%, Missing); small intestine: 62.0482% (minimum 75%, Missing); smooth muscle: 55.9783% (minimum 75%, Missing); spinal cord: 70.7904% (minimum 75%, Missing); spleen: 53.2300% (minimum 65%, Missing); stomach: 60.2339% (minimum 70%, Missing); thymus: 39.9225% (minimum 65%, Missing); thyroid gland: 55.8266% (minimum 65%, Missing); tongue: 47.7958% (minimum 70%, Missing); urinary bladder: 58.3569% (minimum 70%, Missing)",-0.250775,-0.222042,-0.6276,0,80,unavailable,147.7,22.5,31,"bone marrow: 147.7 nTPM (vital, limit 1); thymus: 31 nTPM (manageable, limit 5); tongue: 22.5 nTPM (protected, limit 3); skeletal muscle: 21.9 nTPM (vital, limit 1); cerebellum: 21.4 nTPM (vital, limit 1); lymph node: 21 nTPM (protected, limit 3); retina: 18.7 nTPM (vital, limit 1); spleen: 18.1 nTPM (manageable, limit 5); thyroid gland: 16.3 nTPM (manageable, limit 5); smooth muscle: 16.2 nTPM (vital, limit 1); rectum: 15.6 nTPM (protected, limit 3); colon: 15.4 nTPM (protected, limit 3); urinary bladder: 14.7 nTPM (protected, limit 3); salivary gland: 14.6 nTPM (protected, limit 3); lung: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 3); pancreas: 13.9 nTPM (vital, limit 1); adipose tissue: 13.9 nTPM (manageable, limit 5); stomach: 13.6 nTPM (protected, limit 3); skin: 13.4 nTPM (manageable, limit 5); liver: 13.4 nTPM (vital, limit 1); small intestine: 12.6 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); duodenum: 11.1 nTPM (vital, limit 1); esophagus: 10.8 nTPM (protected, limit 3); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.9 nTPM (vital, limit 1); cerebral cortex: 9.6 nTPM (vital, limit 1); adrenal gland: 9.3 nTPM (vital, limit 1); spinal cord: 8.5 nTPM (vital, limit 1); basal ganglia: 8.5 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); hypothalamus: 7.7 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EPC1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000120659,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"liver: 40.2985% (minimum 60%, Enhanced); lymph node: 18.3673% (minimum 70%, Missing)",0.0423077,-0.516327,-0.197015,0,1,partial,4,12,1.2,"lymph node: 12 nTPM (protected, limit 3)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TNFSF11,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000120669,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.331618,0.139623,0.186842,0,80,unavailable,1.8,5.1,0.5,"tongue: 5.1 nTPM (protected, limit 3); basal ganglia: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SOHLH2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000120952,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRAMEF2,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000121039,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 45.5729% (minimum 65%, Missing); choroid plexus: 69.3069% (minimum 75%, Missing); colon: 68.6275% (minimum 70%, Missing); duodenum: 52.6316% (minimum 75%, Missing); esophagus: 64.5756% (minimum 70%, Missing); kidney: 45.3956% (minimum 75%, Missing); liver: 46.8541% (minimum 75%, Missing); lung: 72.6141% (minimum 75%, Missing); pancreas: 51.1696% (minimum 75%, Missing); pituitary gland: 57.3770% (minimum 75%, Missing); retina: 29.5110% (minimum 75%, Missing); salivary gland: 47.8796% (minimum 70%, Missing); small intestine: 54.0123% (minimum 75%, Missing); smooth muscle: 70.9939% (minimum 75%, Missing); stomach: 59.3220% (minimum 70%, Missing); urinary bladder: 34.4488% (minimum 70%, Missing)",-0.194271,-0.355512,-0.45489,0,80,unavailable,83.6,66.6,41.8,"retina: 83.6 nTPM (vital, limit 1); urinary bladder: 66.6 nTPM (protected, limit 3); kidney: 42.1 nTPM (vital, limit 1); adipose tissue: 41.8 nTPM (manageable, limit 5); liver: 39.7 nTPM (vital, limit 1); salivary gland: 38.1 nTPM (protected, limit 3); pancreas: 33.4 nTPM (vital, limit 1); duodenum: 31.5 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); pituitary gland: 26 nTPM (vital, limit 1); stomach: 24 nTPM (protected, limit 3); esophagus: 19.2 nTPM (protected, limit 3); colon: 16 nTPM (protected, limit 3); choroid plexus: 15.5 nTPM (vital, limit 1); rectum: 14.7 nTPM (protected, limit 3); smooth muscle: 14.3 nTPM (vital, limit 1); lung: 13.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); lymph node: 10.7 nTPM (protected, limit 3); skin: 8.1 nTPM (manageable, limit 5); parathyroid gland: 8.1 nTPM (protected, limit 3); tongue: 7.9 nTPM (protected, limit 3); spleen: 7 nTPM (manageable, limit 5); cerebral cortex: 6.8 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); adrenal gland: 6 nTPM (vital, limit 1); thymus: 5.9 nTPM (manageable, limit 5); amygdala: 5.4 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RDH10,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000121101,True,compatible,,True,True,True,,0.35,0.3,0.213235,0,3,partial,1.7,0.1,0.2,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX14,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,False,gained,selectivity_revised
ENSG00000121152,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 49.6382% (minimum 75%, Missing); lymph node: 63.2841% (minimum 70%, Missing); thymus: 48.5149% (minimum 65%, Missing)",-0.164851,-0.0671587,-0.253618,0,5,partial,34.8,19.9,36.4,"thymus: 36.4 nTPM (manageable, limit 5); bone marrow: 34.8 nTPM (vital, limit 1); lymph node: 19.9 nTPM (protected, limit 3); rectum: 9 nTPM (protected, limit 3); stomach: 3.5 nTPM (protected, limit 3); retina: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / eccrine glands: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: High (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / lymphocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NCAPH,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000121207,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 61.5385% (minimum 75%, Missing); basal ganglia: 42.1053% (minimum 75%, Missing); bone marrow: 61.5385% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); duodenum: 42.1053% (minimum 75%, Missing); hippocampal formation: 57.1429% (minimum 75%, Missing); hypothalamus: 38.0952% (minimum 75%, Missing); liver: 27.5862% (minimum 75%, Missing); lung: 72.7273% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 50.0000% (minimum 75%, Missing); retina: 47.0588% (minimum 75%, Missing); skeletal muscle: 50.0000% (minimum 75%, Missing); small intestine: 34.7826% (minimum 75%, Missing); spinal cord: 32.0000% (minimum 75%, Missing); thyroid gland: 34.7826% (minimum 65%, Missing)",-0.302174,-0.0846154,-0.474138,0,80,unavailable,2.1,0.5,1.5,"liver: 2.1 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRAT,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000121211,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 54.0351% (minimum 75%, Missing); lymph node: 56.8266% (minimum 70%, Missing); thymus: 37.1981% (minimum 65%, Missing)",-0.278019,-0.131734,-0.209649,0,3,partial,13.1,11.7,26,"thymus: 26 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); lymph node: 11.7 nTPM (protected, limit 3); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); thymus / cortical cells: High (Supported); thymus / medullary cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MND1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000121270,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343421,0.3,0.215885,0,80,unavailable,1.6,0,0.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ABCC11,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000121380,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 69.6347% (minimum 75%, Missing); small intestine: 70.9302% (minimum 75%, Missing)",0.312145,0.12033,-0.053653,0,4,partial,13.3,15,1.2,"rectum: 15 nTPM (protected, limit 12); duodenum: 13.3 nTPM (vital, limit 1); small intestine: 12.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BCL2L14,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000121390,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.8537% (minimum 75%, Missing); amygdala: 64.8000% (minimum 75%, Missing); basal ganglia: 64.2857% (minimum 75%, Missing); bone marrow: 31.3953% (minimum 75%, Missing); cerebellum: 56.2500% (minimum 75%, Missing); cerebral cortex: 55.2273% (minimum 75%, Missing); colon: 62.7907% (minimum 70%, Missing); duodenum: 66.7582% (minimum 75%, Missing); esophagus: 64.1161% (minimum 70%, Missing); heart muscle: 69.4286% (minimum 75%, Missing); hippocampal formation: 62.9534% (minimum 75%, Missing); hypothalamus: 61.6751% (minimum 75%, Missing); kidney: 67.3130% (minimum 75%, Missing); liver: 73.8602% (minimum 75%, Missing); lung: 71.6814% (minimum 75%, Missing); lymph node: 54.4843% (minimum 70%, Missing); midbrain: 68.8385% (minimum 75%, Missing); pancreas: 72.3214% (minimum 75%, Missing); pituitary gland: 70.6395% (minimum 75%, Missing); rectum: 61.8321% (minimum 70%, Missing); retina: 58.9806% (minimum 75%, Missing); skeletal muscle: 54.6067% (minimum 75%, Missing); skin: 63.4465% (minimum 65%, Missing); small intestine: 66.9421% (minimum 75%, Missing); smooth muscle: 66.5753% (minimum 75%, Missing); spinal cord: 69.8276% (minimum 75%, Missing); stomach: 67.5000% (minimum 70%, Missing); thymus: 51.9231% (minimum 65%, Missing); tongue: 66.3934% (minimum 70%, Missing); urinary bladder: 55.2273% (minimum 70%, Missing)",-0.130769,-0.155157,-0.436047,0,4,partial,53.1,20.3,22.5,"bone marrow: 53.1 nTPM (vital, limit 1); thymus: 22.5 nTPM (manageable, limit 5); lymph node: 20.3 nTPM (protected, limit 3); skeletal muscle: 20.2 nTPM (vital, limit 1); urinary bladder: 19.7 nTPM (protected, limit 3); cerebral cortex: 19.7 nTPM (vital, limit 1); cerebellum: 18.9 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); rectum: 15 nTPM (protected, limit 3); colon: 14.4 nTPM (protected, limit 3); hippocampal formation: 14.3 nTPM (vital, limit 1); skin: 14 nTPM (manageable, limit 5); esophagus: 13.6 nTPM (protected, limit 3); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); adrenal gland: 12.6 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 3); smooth muscle: 12.2 nTPM (vital, limit 1); duodenum: 12.1 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); kidney: 11.8 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 3); midbrain: 11 nTPM (vital, limit 1); spleen: 10.9 nTPM (manageable, limit 5); heart muscle: 10.7 nTPM (vital, limit 1); adipose tissue: 10.6 nTPM (manageable, limit 5); spinal cord: 10.5 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); salivary gland: 9.7 nTPM (protected, limit 3); lung: 9.6 nTPM (vital, limit 1); pancreas: 9.3 nTPM (vital, limit 1); parathyroid gland: 9.1 nTPM (protected, limit 3); liver: 8.6 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PSPC1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000121446,True,compatible,,True,True,True,,0.31,0.3,0.25,0,80,unavailable,0,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RGSL1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000121570,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 46.5909% (minimum 60%, Enhanced); thymus: 25.3086% (minimum 65%, Missing)",-0.396914,0.3,-0.134091,0,2,partial,4.7,0.5,12.1,"thymus: 12.1 nTPM (manageable, limit 5)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DPPA4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000121621,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 62.1495% (minimum 75%, Missing); thymus: 58.8496% (minimum 65%, Missing)",-0.0615044,0.047191,-0.128505,0,4,partial,8.1,4.5,9.3,"thymus: 9.3 nTPM (manageable, limit 5); bone marrow: 8.1 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 3); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KIF18A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000121634,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0.1,0,0,,eye / lens fiber cells: Medium (Enhanced),59,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GJA8,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000121690,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 53.4113% (minimum 75%, Missing); kidney: 59.3074% (minimum 75%, Missing); liver: 27.6210% (minimum 75%, Missing); small intestine: 49.2806% (minimum 75%, Missing)",0.175301,0.145679,-0.47379,0,80,unavailable,71.8,5,5.8,"liver: 71.8 nTPM (vital, limit 1); small intestine: 28.2 nTPM (vital, limit 1); duodenum: 23.9 nTPM (vital, limit 1); kidney: 18.8 nTPM (vital, limit 1); skin: 5.8 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 3); skeletal muscle: 4.7 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 3); esophagus: 4.3 nTPM (protected, limit 3); pancreas: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DEPDC7,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000121903,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.3704% (minimum 75%, Missing); cerebellum: 67.8571% (minimum 75%, Missing); cerebral cortex: 67.8571% (minimum 75%, Missing); choroid plexus: 65.5172% (minimum 75%, Missing); colon: 65.5172% (minimum 70%, Missing); duodenum: 43.1818% (minimum 75%, Missing); heart muscle: 51.3514% (minimum 75%, Uncertain); kidney: 65.5172% (minimum 75%, Missing); lung: 67.8571% (minimum 75%, Missing); pancreas: 70.3704% (minimum 75%, Missing); parathyroid gland: 43.1818% (minimum 70%, Missing); pituitary gland: 67.8571% (minimum 75%, Missing); rectum: 61.2903% (minimum 70%, Missing); retina: 54.2857% (minimum 75%, Missing); salivary gland: 67.8571% (minimum 70%, Missing); skeletal muscle: 63.3333% (minimum 75%, Missing); small intestine: 61.2903% (minimum 75%, Missing); smooth muscle: 57.5758% (minimum 75%, Missing); stomach: 61.2903% (minimum 70%, Missing); thymus: 61.2903% (minimum 65%, Missing); thyroid gland: 61.2903% (minimum 65%, Missing); tongue: 50.0000% (minimum 70%, Missing); urinary bladder: 67.8571% (minimum 70%, Missing)",-0.0370968,-0.268182,-0.318182,0,1,partial,2.5,2.5,1.2,"duodenum: 2.5 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZSCAN20,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000121904,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 42.8571% (minimum 75%, Missing); amygdala: 15.7895% (minimum 75%, Missing); basal ganglia: 10.7143% (minimum 75%, Missing); cerebellum: 13.6364% (minimum 75%, Missing); cerebral cortex: 11.5385% (minimum 75%, Missing); choroid plexus: 60.0000% (minimum 75%, Missing); duodenum: 25.0000% (minimum 75%, Missing); heart muscle: 60.0000% (minimum 75%, Missing); hippocampal formation: 13.6364% (minimum 75%, Missing); hypothalamus: 11.1111% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); midbrain: 17.6471% (minimum 75%, Missing); pancreas: 18.7500% (minimum 75%, Missing); retina: 27.2727% (minimum 75%, Missing); smooth muscle: 60.0000% (minimum 75%, Missing); spinal cord: 30.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); thyroid gland: 37.5000% (minimum 65%, Missing)",-0.275,0.05,-0.642857,0,80,unavailable,2.5,0.1,0.5,"basal ganglia: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CSMD2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000121988,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.4545% (minimum 75%, Missing); basal ganglia: 73.8095% (minimum 75%, Missing); cerebral cortex: 72.0930% (minimum 75%, Missing); pancreas: 72.0930% (minimum 75%, Missing); pituitary gland: 70.4545% (minimum 75%, Missing); retina: 70.4545% (minimum 75%, Missing); skeletal muscle: 62.0000% (minimum 75%, Missing)",0.106098,0.0948718,-0.13,0,80,unavailable,1.9,0.8,1,"skeletal muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZRANB3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000122145,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.0512987,0.281818,0.25,0,80,unavailable,0,0.2,4.6,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TBX22,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000122304,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349991,0.3,0.249859,0,1,partial,4.5,2,3.5,"pituitary gland: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRM2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000122483,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 55.6338% (minimum 75%, Missing); lymph node: 58.5185% (minimum 70%, Missing); thymus: 63.2000% (minimum 65%, Missing)",-0.018,-0.114815,-0.193662,0,3,partial,6.3,5.6,4.6,"bone marrow: 6.3 nTPM (vital, limit 1); lymph node: 5.6 nTPM (protected, limit 3); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC18,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000122550,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.0878% (minimum 75%, Missing); amygdala: 74.0942% (minimum 75%, Missing); basal ganglia: 74.7715% (minimum 75%, Missing); cerebellum: 73.8267% (minimum 75%, Missing); cerebral cortex: 72.7758% (minimum 75%, Missing); heart muscle: 45.4950% (minimum 75%, Missing); hypothalamus: 72.2615% (minimum 75%, Missing); midbrain: 73.5612% (minimum 75%, Missing); retina: 73.6937% (minimum 75%, Missing)",0.121698,0.0926357,-0.29505,0,2,partial,49,10.7,12.1,"heart muscle: 49 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); midbrain: 14.7 nTPM (vital, limit 1); retina: 14.6 nTPM (vital, limit 1); cerebellum: 14.5 nTPM (vital, limit 1); amygdala: 14.3 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.6 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); bone marrow: 12.2 nTPM (vital, limit 1); thymus: 12.1 nTPM (manageable, limit 5); kidney: 11.5 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 3); skin: 10.5 nTPM (manageable, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); liver: 10.1 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 3); adipose tissue: 9.2 nTPM (manageable, limit 5); thyroid gland: 9 nTPM (manageable, limit 5); esophagus: 8.8 nTPM (protected, limit 3); colon: 8.8 nTPM (protected, limit 3); skeletal muscle: 8.7 nTPM (vital, limit 1); urinary bladder: 8.5 nTPM (protected, limit 3); salivary gland: 8.3 nTPM (protected, limit 3); lymph node: 8.2 nTPM (protected, limit 3); spleen: 7.8 nTPM (manageable, limit 5); choroid plexus: 7.7 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); rectum: 7.6 nTPM (protected, limit 3); duodenum: 7.5 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 3)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KLHL7,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000122591,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 49.8258% (minimum 65%, Missing); amygdala: 71.1443% (minimum 75%, Missing); colon: 60.3376% (minimum 70%, Missing); duodenum: 60.8511% (minimum 75%, Missing); esophagus: 54.7893% (minimum 70%, Missing); heart muscle: 58.6066% (minimum 75%, Missing); hippocampal formation: 64.7059% (minimum 75%, Missing); liver: 63.2743% (minimum 75%, Missing); lung: 51.8116% (minimum 75%, Missing); lymph node: 56.0784% (minimum 70%, Missing); midbrain: 71.5000% (minimum 75%, Missing); pancreas: 70.4433% (minimum 75%, Missing); pituitary gland: 74.8691% (minimum 75%, Missing); salivary gland: 68.4211% (minimum 70%, Missing); skeletal muscle: 37.1429% (minimum 75%, Missing); small intestine: 68.0952% (minimum 75%, Missing); smooth muscle: 56.0784% (minimum 75%, Missing); spinal cord: 72.5888% (minimum 75%, Missing); spleen: 55.4264% (minimum 65%, Missing); tongue: 49.4810% (minimum 70%, Missing); urinary bladder: 61.3734% (minimum 70%, Missing)",-0.151742,-0.20519,-0.378571,0,6,partial,24.2,14.6,14.4,"skeletal muscle: 24.2 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 3); adipose tissue: 14.4 nTPM (manageable, limit 5); lung: 13.3 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 3); spleen: 11.5 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 3); heart muscle: 10.1 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 3); duodenum: 9.2 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 3); liver: 8.3 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 3); thyroid gland: 6.4 nTPM (manageable, limit 5); pancreas: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); kidney: 4.5 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); hypothalamus: 4.4 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 3); cerebral cortex: 3.8 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HYCC1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000122728,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,1.6,0,0,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TAF1L,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000122778,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 73.6111% (minimum 75%, Missing); cerebral cortex: 55.7895% (minimum 75%, Missing); hippocampal formation: 72.6027% (minimum 75%, Missing); hypothalamus: 72.6027% (minimum 75%, Missing); kidney: 58.2418% (minimum 75%, Missing); lung: 74.6479% (minimum 75%, Missing); pancreas: 46.0870% (minimum 75%, Missing); parathyroid gland: 68.8312% (minimum 70%, Missing); retina: 48.6239% (minimum 75%, Missing); salivary gland: 69.7368% (minimum 70%, Missing)",0.0473684,-0.0116883,-0.28913,0,3,partial,6.2,2.4,2.3,"pancreas: 6.2 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KIAA1549,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000123165,True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ACTRT1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000123171,True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC70,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000123219,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 34.9206% (minimum 75%, Missing); colon: 60.2740% (minimum 70%, Missing); duodenum: 61.9718% (minimum 75%, Missing); lymph node: 47.8261% (minimum 70%, Missing); rectum: 53.4413% (minimum 70%, Missing); skin: 60.8295% (minimum 65%, Missing); small intestine: 61.1111% (minimum 75%, Missing); thymus: 37.8223% (minimum 65%, Missing)",-0.271777,-0.221739,-0.400794,0,80,unavailable,24.6,14.4,21.7,"bone marrow: 24.6 nTPM (vital, limit 1); thymus: 21.7 nTPM (manageable, limit 5); lymph node: 14.4 nTPM (protected, limit 3); rectum: 11.5 nTPM (protected, limit 3); colon: 8.7 nTPM (protected, limit 3); skin: 8.5 nTPM (manageable, limit 5); small intestine: 8.4 nTPM (vital, limit 1); duodenum: 8.1 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 3); stomach: 5.4 nTPM (protected, limit 3); smooth muscle: 3.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CENPK,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000123473,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 39.3103% (minimum 75%, Missing); colon: 61.2903% (minimum 70%, Missing); duodenum: 68.6747% (minimum 75%, Missing); lymph node: 57.0000% (minimum 70%, Missing); rectum: 51.8182% (minimum 70%, Missing); small intestine: 71.2500% (minimum 75%, Missing); thymus: 39.8601% (minimum 65%, Missing)",-0.251399,-0.181818,-0.356897,0,80,unavailable,8.8,5.3,8.6,"bone marrow: 8.8 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); rectum: 5.3 nTPM (protected, limit 3); lymph node: 4.3 nTPM (protected, limit 3); colon: 3.6 nTPM (protected, limit 3); duodenum: 2.6 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,STIL,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000123485,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 18.7500% (minimum 75%, Missing); duodenum: 73.4694% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Uncertain); lymph node: 46.7532% (minimum 70%, Missing); rectum: 67.9245% (minimum 70%, Missing); small intestine: 74.4828% (minimum 75%, Missing); thymus: 26.7327% (minimum 65%, Missing)",-0.382673,-0.232468,-0.5625,0,1,partial,46.8,12.3,29.6,"bone marrow: 46.8 nTPM (vital, limit 1); thymus: 29.6 nTPM (manageable, limit 5); lymph node: 12.3 nTPM (protected, limit 3); esophagus: 5.4 nTPM (protected, limit 3); rectum: 5.1 nTPM (protected, limit 3); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); small intestine: 3.7 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HJURP,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000123496,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"hypothalamus: 71.3235% (minimum 75%, Missing); pituitary gland: 71.3235% (minimum 75%, Missing)",0.282692,0.171257,-0.0367647,0,80,unavailable,11.7,4.3,2.1,"hypothalamus: 11.7 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 3); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IL13RA2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000123500,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lung: 67.0588% (minimum 75%, Missing); pancreas: 64.0449% (minimum 75%, Missing); salivary gland: 68.6747% (minimum 70%, Missing)",0.0537037,-0.013253,-0.109551,0,80,unavailable,3.2,2.6,2.4,"pancreas: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,COL10A1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000123569,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,H2BW1,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000123576,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ESX1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000123584,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEA9,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000123594,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ATXN3L,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000123975,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.2485% (minimum 75%, Missing); bone marrow: 50.8303% (minimum 75%, Missing); lymph node: 64.2933% (minimum 70%, Missing); thymus: 60.5228% (minimum 65%, Missing)",-0.0447721,-0.0570666,-0.241697,0,1,partial,174.7,100.3,117.8,"bone marrow: 174.7 nTPM (vital, limit 1); thymus: 117.8 nTPM (manageable, limit 5); lymph node: 100.3 nTPM (protected, limit 3); adrenal gland: 80.2 nTPM (vital, limit 1); esophagus: 51.7 nTPM (protected, limit 3); colon: 42.6 nTPM (protected, limit 3); duodenum: 42 nTPM (vital, limit 1); rectum: 39.6 nTPM (protected, limit 3); kidney: 34.6 nTPM (vital, limit 1); small intestine: 32.1 nTPM (vital, limit 1); spleen: 31.8 nTPM (manageable, limit 5); liver: 30.2 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); urinary bladder: 25.6 nTPM (protected, limit 3); lung: 23.3 nTPM (vital, limit 1); stomach: 19.8 nTPM (protected, limit 3); skin: 19.3 nTPM (manageable, limit 5); parathyroid gland: 19.1 nTPM (protected, limit 3); smooth muscle: 16.9 nTPM (vital, limit 1); adipose tissue: 13.2 nTPM (manageable, limit 5); thyroid gland: 12.4 nTPM (manageable, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); hippocampal formation: 10.7 nTPM (vital, limit 1); salivary gland: 10.5 nTPM (protected, limit 3); amygdala: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.3 nTPM (vital, limit 1); heart muscle: 9.9 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); cerebellum: 9.1 nTPM (vital, limit 1); spinal cord: 8.6 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); tongue: 4.6 nTPM (protected, limit 3); pancreas: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CKS2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000123977,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 46.7351% (minimum 75%, Missing)",0.342079,0.290119,-0.282649,0,10,partial,57.1,0.8,0.6,"choroid plexus: 57.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 2); basal ganglia: 6.8 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 2); amygdala: 2.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DAW1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000123999,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.0034% (minimum 75%, Missing)",0.35,0.3,-0.169966,0,1,partial,73.2,1.5,3.2,"adrenal gland: 73.2 nTPM (vital, limit 1); heart muscle: 15.8 nTPM (vital, limit 6); pancreas: 11.9 nTPM (vital, limit 6); basal ganglia: 10.4 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 6); pituitary gland: 6.4 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,INHA,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000124089,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 6.6667% (minimum 75%, Missing)",0.35,0.3,-0.683333,0,2,partial,1.4,0,0,"hypothalamus: 1.4 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Uncertain); hypothalamus / neuronal projections: Low (Uncertain); hypothalamus / synapses: Medium (Uncertain),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MC3R,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000124092,True,compatible,,True,True,True,,0.340826,0.290826,0.173077,0,2,partial,0.9,0.4,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CTCFL,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000124103,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328744,0.285409,0.109932,0,80,unavailable,16.5,1.5,2.2,"bone marrow: 16.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM209A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000124116,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 54.4944% (minimum 65%, Missing)",-0.105056,0.289796,0.196341,0,80,unavailable,1.1,0.2,16.2,"skin: 16.2 nTPM (manageable, limit 5); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,WFDC3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000124196,True,compatible,,True,True,True,,0.348164,0.3,0.25,0,1,partial,0.3,1.4,0.7,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GTSF1L,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000124198,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6364% (minimum 65%, Missing); adrenal gland: 44.0000% (minimum 75%, Missing); basal ganglia: 74.3961% (minimum 75%, Missing); bone marrow: 59.9222% (minimum 75%, Missing); cerebellum: 65.2542% (minimum 75%, Missing); cerebral cortex: 62.3482% (minimum 75%, Missing); colon: 52.9210% (minimum 70%, Missing); duodenum: 53.6585% (minimum 75%, Missing); esophagus: 59.0038% (minimum 70%, Missing); heart muscle: 54.2254% (minimum 75%, Missing); hippocampal formation: 70.9677% (minimum 75%, Missing); hypothalamus: 71.2963% (minimum 75%, Missing); kidney: 50.9934% (minimum 75%, Missing); liver: 56.2044% (minimum 75%, Missing); lung: 66.9565% (minimum 75%, Missing); lymph node: 61.8474% (minimum 70%, Missing); midbrain: 70.3196% (minimum 75%, Missing); pancreas: 45.1613% (minimum 75%, Missing); parathyroid gland: 16.3482% (minimum 70%, Missing); pituitary gland: 64.4351% (minimum 75%, Missing); rectum: 50.3268% (minimum 70%, Missing); retina: 69.6833% (minimum 75%, Missing); salivary gland: 59.0038% (minimum 70%, Missing); skeletal muscle: 57.4627% (minimum 75%, Missing); skin: 58.7786% (minimum 65%, Missing); small intestine: 59.2308% (minimum 75%, Missing); smooth muscle: 62.8571% (minimum 75%, Missing); spinal cord: 68.1416% (minimum 75%, Missing); spleen: 60.3922% (minimum 65%, Missing); stomach: 49.3590% (minimum 70%, Missing); thymus: 58.3333% (minimum 65%, Missing); thyroid gland: 40.0000% (minimum 65%, Missing); tongue: 46.8085% (minimum 70%, Missing); urinary bladder: 58.7786% (minimum 70%, Missing)",-0.25,-0.536518,-0.31,0,4,partial,19.6,78.8,23.1,"parathyroid gland: 78.8 nTPM (protected, limit 3); thyroid gland: 23.1 nTPM (manageable, limit 5); adrenal gland: 19.6 nTPM (vital, limit 1); pancreas: 18.7 nTPM (vital, limit 1); tongue: 17.5 nTPM (protected, limit 3); stomach: 15.8 nTPM (protected, limit 3); rectum: 15.2 nTPM (protected, limit 3); kidney: 14.8 nTPM (vital, limit 1); colon: 13.7 nTPM (protected, limit 3); duodenum: 13.3 nTPM (vital, limit 1); heart muscle: 13 nTPM (vital, limit 1); liver: 12 nTPM (vital, limit 1); skeletal muscle: 11.4 nTPM (vital, limit 1); thymus: 11 nTPM (manageable, limit 5); skin: 10.8 nTPM (manageable, limit 5); urinary bladder: 10.8 nTPM (protected, limit 3); salivary gland: 10.7 nTPM (protected, limit 3); esophagus: 10.7 nTPM (protected, limit 3); small intestine: 10.6 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); spleen: 10.1 nTPM (manageable, limit 5); lymph node: 9.5 nTPM (protected, limit 3); cerebral cortex: 9.3 nTPM (vital, limit 1); smooth muscle: 9.1 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); retina: 6.7 nTPM (vital, limit 1); midbrain: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.3 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ARFGEF2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000124227,True,compatible,,True,True,True,,0.322222,0.3,0.195946,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ANKRD60,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,True,True,True,True,gained,selectivity_revised
ENSG00000124232,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 0.0212% (minimum 75%, Missing); stomach: 5.4054% (minimum 55%, Enhanced)",0,-0.495946,-0.749788,0,0,routine_complete,944.9,3.5,0.2,"pancreas: 944.9 nTPM (vital, limit 1)",pancreas / pancreatic endocrine cells: Medium (Enhanced),55,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RBPJL,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000124237,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.349092,0.3,0.237879,0,4,partial,24.7,0.1,0.4,"lung: 24.7 nTPM (vital, limit 6); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,CIMIP1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000124260,True,compatible,,True,True,True,,0.35,0.3,0.23913,0,4,partial,0.3,0.2,0.4,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEA10,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734,"Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016",False,True,True,True,True,gained,selectivity_revised
ENSG00000124449,True,compatible,,True,True,True,,0.35,0.3,0.249313,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IRGC,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000124467,True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0.2,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PSG8,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased",True,True,True,True,True,unchanged,
ENSG00000124490,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.241717,0,1,partial,16.5,15.1,0.5,"bone marrow: 16.5 nTPM (vital, limit 6); salivary gland: 15.1 nTPM (protected, limit 12); choroid plexus: 4.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CRISP2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000124610,False,excluded,positive_ihc_outside_permitted;family_exclusion,True,True,True,,0,0.3,0.25,0,5,partial,0,0,0.1,,esophagus / squamous epithelial cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / keratinocytes; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,H1-1,current_adaptive,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000124613,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.2222% (minimum 75%, Missing); amygdala: 72.2222% (minimum 75%, Missing); basal ganglia: 63.4146% (minimum 75%, Missing); cerebellum: 65.8228% (minimum 75%, Missing); cerebral cortex: 62.6506% (minimum 75%, Missing); hippocampal formation: 70.2703% (minimum 75%, Missing); hypothalamus: 72.2222% (minimum 75%, Missing); kidney: 65.8228% (minimum 75%, Missing); lung: 74.2857% (minimum 75%, Missing); pancreas: 71.2329% (minimum 75%, Missing); parathyroid gland: 59.0909% (minimum 70%, Missing); retina: 72.2222% (minimum 75%, Missing); smooth muscle: 69.3333% (minimum 75%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing)",-0.0785714,-0.109091,-0.123494,0,80,unavailable,3.1,3.6,3.9,"parathyroid gland: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF391,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000124678,True,compatible,,True,True,True,,0.349698,0.299095,0.249095,0,2,partial,0.5,0.4,0.4,,,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TCP11,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000124721,True,compatible,,True,True,True,,0.176087,0.238272,0.237013,0,80,unavailable,0.1,0.5,1.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAH8,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000124812,True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0.3,0,,,49,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CRISP1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000124818,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.261538,0.212069,0,1,partial,0.4,0.1,0,,retina / photoreceptor cells: High (Supported),63,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OPN5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000124900,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRIM51,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000125207,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.224178,0,3,partial,1.1,0,0.4,"retina: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PIWIL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000125245,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 56.9507% (minimum 60%, Enhanced); lymph node: 25.0493% (minimum 70%, Missing); spleen: 55.4585% (minimum 65%, Missing); thymus: 62.2549% (minimum 65%, Missing)",-0.0954148,-0.449507,-0.0304933,0,0,routine_complete,9.6,38,10.2,"lymph node: 38 nTPM (protected, limit 3); spleen: 10.2 nTPM (manageable, limit 5); bone marrow: 9.6 nTPM (vital, limit 6); thymus: 7.7 nTPM (manageable, limit 5)",lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GPR18,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000125319,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 54.6798% (minimum 75%, Missing)",0.184586,0.104348,-0.203202,0,0,routine_complete,9.2,2.7,2.2,"bone marrow: 9.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HROB,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000125388,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.312529,0.207285,0.0574656,0,7,partial,12.1,4.2,3.2,"cerebellum: 12.1 nTPM (vital, limit 2); retina: 9.8 nTPM (vital, limit 1); spinal cord: 6.5 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 2); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 2); skeletal muscle: 4.6 nTPM (vital, limit 2); tongue: 4.2 nTPM (protected, limit 3); parathyroid gland: 4.2 nTPM (protected, limit 4); adrenal gland: 3.2 nTPM (vital, limit 2); choroid plexus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 2)",bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebral cortex / neuronal cells: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GRK4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000125409,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.3467,0.2967,0.205696,0,5,partial,2.5,0.4,0.7,"choroid plexus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); lung / macrophages: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEKT3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000125531,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340566,0.293377,0.238701,0,80,unavailable,1.2,0.7,1,"kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FNDC11,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000125533,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 66.6667% (minimum 75%, Missing); thymus: 50.0000% (minimum 65%, Missing)",-0.15,0.3,-0.0833333,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BHLHE23,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000125633,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 56.8282% (minimum 60%, Approved); adrenal gland: 47.9554% (minimum 75%, Missing); amygdala: 64.1791% (minimum 75%, Missing); basal ganglia: 59.7222% (minimum 75%, Missing); bone marrow: 37.5000% (minimum 70%, Approved); cerebellum: 45.1049% (minimum 75%, Missing); cerebral cortex: 59.1743% (minimum 75%, Missing); choroid plexus: 46.4029% (minimum 75%, Missing); colon: 54.2017% (minimum 70%, Missing); duodenum: 52.6531% (minimum 75%, Missing); esophagus: 64.1791% (minimum 70%, Missing); heart muscle: 38.5075% (minimum 75%, Missing); hippocampal formation: 65.1515% (minimum 75%, Missing); hypothalamus: 61.4286% (minimum 75%, Missing); kidney: 57.5893% (minimum 75%, Missing); liver: 62.9268% (minimum 75%, Missing); lung: 53.0864% (minimum 75%, Missing); lymph node: 56.0870% (minimum 70%, Missing); midbrain: 63.5468% (minimum 75%, Missing); pancreas: 50.3906% (minimum 75%, Missing); parathyroid gland: 45.5830% (minimum 70%, Missing); pituitary gland: 45.2632% (minimum 75%, Missing); rectum: 55.6034% (minimum 70%, Missing); retina: 33.8583% (minimum 75%, Missing); salivary gland: 59.4470% (minimum 70%, Missing); skeletal muscle: 50.9881% (minimum 75%, Missing); skin: 54.6610% (minimum 65%, Missing); small intestine: 50.9881% (minimum 75%, Missing); smooth muscle: 62.3188% (minimum 75%, Missing); spinal cord: 64.1791% (minimum 75%, Missing); spleen: 52.2267% (minimum 60%, Approved); stomach: 59.4470% (minimum 70%, Missing); thymus: 56.8282% (minimum 65%, Missing); thyroid gland: 52.8689% (minimum 65%, Missing); tongue: 56.5789% (minimum 70%, Missing); urinary bladder: 60.8491% (minimum 70%, Missing)",-0.121311,-0.24417,-0.411417,0,5,partial,25.2,15.4,11.8,"retina: 25.2 nTPM (vital, limit 1); bone marrow: 21.5 nTPM (vital, limit 2); heart muscle: 20.6 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); pituitary gland: 15.6 nTPM (vital, limit 1); parathyroid gland: 15.4 nTPM (protected, limit 3); choroid plexus: 14.9 nTPM (vital, limit 1); adrenal gland: 14 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); skeletal muscle: 12.4 nTPM (vital, limit 1); small intestine: 12.4 nTPM (vital, limit 1); spleen: 11.8 nTPM (manageable, limit 10); duodenum: 11.6 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (manageable, limit 5); lung: 11.4 nTPM (vital, limit 1); colon: 10.9 nTPM (protected, limit 3); skin: 10.7 nTPM (manageable, limit 5); rectum: 10.3 nTPM (protected, limit 3); lymph node: 10.1 nTPM (protected, limit 3); tongue: 9.9 nTPM (protected, limit 3); thymus: 9.8 nTPM (manageable, limit 5); kidney: 9.5 nTPM (vital, limit 1); cerebral cortex: 8.9 nTPM (vital, limit 1); stomach: 8.8 nTPM (protected, limit 3); salivary gland: 8.8 nTPM (protected, limit 3); basal ganglia: 8.7 nTPM (vital, limit 1); urinary bladder: 8.3 nTPM (protected, limit 3); hypothalamus: 8.1 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); liver: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); amygdala: 7.2 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 3); hippocampal formation: 6.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC93,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000125788,True,compatible,,True,True,True,,0.35,0.3,0.24992,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DEFB126,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000125815,True,compatible,,True,True,True,,0.35,0.3,0.245413,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CST8,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000125816,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"hypothalamus: 68.7500% (minimum 75%, Missing)",0.35,0.3,-0.0625,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NKX2-4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000125823,True,compatible,,True,True,True,,0.35,0.244444,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CSTL1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000125864,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 62.7119% (minimum 75%, Missing); basal ganglia: 53.6232% (minimum 75%, Missing); cerebral cortex: 57.8125% (minimum 60%, Enhanced); choroid plexus: 56.0606% (minimum 75%, Missing); hippocampal formation: 63.7931% (minimum 75%, Missing); hypothalamus: 61.6667% (minimum 75%, Missing); kidney: 50.6849% (minimum 60%, Enhanced); midbrain: 62.7119% (minimum 75%, Missing); spinal cord: 41.5730% (minimum 75%, Missing)",0.106557,0.17549,-0.33427,0,1,partial,5.2,1.4,2.4,"spinal cord: 5.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1)",eye / lens fiber cells: Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BFSP1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000125888,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349068,0.3,0.144094,0,5,partial,19.8,0.2,1.3,"pancreas: 19.8 nTPM (vital, limit 2); choroid plexus: 1.3 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BANF2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000125900,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.248224,0,2,partial,2.7,1.1,1.5,,kidney / cells in tubules: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SIRPD,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000125903,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,DEFB129,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000125965,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.0000% (minimum 65%, Missing); basal ganglia: 64.7059% (minimum 75%, Missing); choroid plexus: 68.7500% (minimum 75%, Missing); colon: 42.3077% (minimum 70%, Missing); heart muscle: 73.3333% (minimum 75%, Missing); lung: 33.3333% (minimum 75%, Missing); pituitary gland: 39.2857% (minimum 75%, Missing); salivary gland: 10.2804% (minimum 70%, Missing); smooth muscle: 64.7059% (minimum 75%, Missing)",-0.1,-0.597196,-0.416667,0,80,unavailable,2.2,9.6,0.9,"salivary gland: 9.6 nTPM (protected, limit 3); lung: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GDF5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000125975,True,compatible,,True,True,True,,0.344236,0.3,0.24711,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C20orf173,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000126216,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.7944% (minimum 65%, Missing); adrenal gland: 62.9344% (minimum 75%, Missing); amygdala: 68.7764% (minimum 75%, Missing); basal ganglia: 67.6349% (minimum 75%, Missing); bone marrow: 34.5339% (minimum 75%, Missing); cerebellum: 58.0071% (minimum 75%, Missing); cerebral cortex: 63.1783% (minimum 75%, Missing); colon: 61.2782% (minimum 70%, Missing); duodenum: 65.7258% (minimum 75%, Missing); esophagus: 61.0487% (minimum 70%, Missing); heart muscle: 64.1732% (minimum 75%, Missing); hippocampal formation: 67.9167% (minimum 75%, Missing); hypothalamus: 68.2008% (minimum 75%, Missing); kidney: 65.9919% (minimum 75%, Missing); liver: 53.2680% (minimum 75%, Missing); lung: 61.2782% (minimum 75%, Missing); lymph node: 52.9221% (minimum 70%, Missing); midbrain: 67.3554% (minimum 75%, Missing); pancreas: 61.7424% (minimum 75%, Missing); parathyroid gland: 65.7258% (minimum 70%, Missing); pituitary gland: 68.2008% (minimum 75%, Missing); rectum: 62.6923% (minimum 70%, Missing); retina: 59.0580% (minimum 75%, Missing); salivary gland: 61.9772% (minimum 70%, Missing); skeletal muscle: 58.4229% (minimum 75%, Missing); skin: 54.3333% (minimum 65%, Missing); small intestine: 59.9265% (minimum 75%, Missing); smooth muscle: 57.3944% (minimum 75%, Missing); spinal cord: 62.4521% (minimum 75%, Missing); spleen: 52.9221% (minimum 65%, Missing); stomach: 63.6719% (minimum 70%, Missing); thymus: 46.8391% (minimum 65%, Missing); thyroid gland: 61.2782% (minimum 65%, Missing); tongue: 65.4618% (minimum 70%, Missing); urinary bladder: 60.5948% (minimum 70%, Missing)",-0.181609,-0.170779,-0.404661,0,12,partial,30.9,14.5,18.5,"bone marrow: 30.9 nTPM (vital, limit 1); thymus: 18.5 nTPM (manageable, limit 5); spleen: 14.5 nTPM (manageable, limit 5); lymph node: 14.5 nTPM (protected, limit 3); liver: 14.3 nTPM (vital, limit 1); skin: 13.7 nTPM (manageable, limit 5); adipose tissue: 12.4 nTPM (manageable, limit 5); smooth muscle: 12.1 nTPM (vital, limit 1); cerebellum: 11.8 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); small intestine: 10.9 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 3); esophagus: 10.4 nTPM (protected, limit 3); lung: 10.3 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (manageable, limit 5); colon: 10.3 nTPM (protected, limit 3); pancreas: 10.1 nTPM (vital, limit 1); salivary gland: 10 nTPM (protected, limit 3); spinal cord: 9.8 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 3); adrenal gland: 9.6 nTPM (vital, limit 1); cerebral cortex: 9.5 nTPM (vital, limit 1); stomach: 9.3 nTPM (protected, limit 3); heart muscle: 9.1 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 3); parathyroid gland: 8.5 nTPM (protected, limit 3); duodenum: 8.5 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); midbrain: 7.9 nTPM (vital, limit 1); basal ganglia: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.7 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); choroid plexus: 4.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TUBGCP3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000126246,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 46.7626% (minimum 65%, Missing); adrenal gland: 38.0117% (minimum 75%, Missing); amygdala: 52.8455% (minimum 75%, Missing); basal ganglia: 56.5217% (minimum 75%, Missing); bone marrow: 32.1782% (minimum 75%, Uncertain); cerebellum: 61.9048% (minimum 75%, Missing); cerebral cortex: 59.0909% (minimum 75%, Missing); choroid plexus: 54.6218% (minimum 75%, Missing); colon: 51.1811% (minimum 70%, Missing); duodenum: 53.2787% (minimum 75%, Missing); esophagus: 63.1068% (minimum 70%, Uncertain); heart muscle: 60.1852% (minimum 75%, Missing); hippocampal formation: 57.0175% (minimum 75%, Missing); hypothalamus: 55.5556% (minimum 75%, Missing); kidney: 32.3383% (minimum 75%, Missing); liver: 11.7754% (minimum 75%, Missing); lung: 37.1429% (minimum 75%, Missing); lymph node: 16.7526% (minimum 70%, Missing); midbrain: 48.8722% (minimum 75%, Missing); pancreas: 41.9355% (minimum 75%, Missing); pituitary gland: 54.6218% (minimum 75%, Missing); rectum: 51.1811% (minimum 70%, Missing); retina: 60.7477% (minimum 75%, Missing); salivary gland: 46.0993% (minimum 70%, Uncertain); skeletal muscle: 60.1852% (minimum 75%, Missing); skin: 61.3208% (minimum 65%, Uncertain); small intestine: 33.6788% (minimum 75%, Missing); smooth muscle: 60.7477% (minimum 75%, Uncertain); spinal cord: 46.4286% (minimum 75%, Missing); spleen: 18.8953% (minimum 65%, Missing); stomach: 46.0993% (minimum 70%, Missing); thymus: 34.7594% (minimum 65%, Missing); thyroid gland: 48.5075% (minimum 65%, Missing); urinary bladder: 48.5075% (minimum 70%, Missing)",-0.461047,-0.532474,-0.632246,0,1,partial,48.7,32.3,27.9,"liver: 48.7 nTPM (vital, limit 1); lymph node: 32.3 nTPM (protected, limit 3); spleen: 27.9 nTPM (manageable, limit 5); bone marrow: 13.7 nTPM (vital, limit 1); kidney: 13.6 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); thymus: 12.2 nTPM (manageable, limit 5); lung: 11 nTPM (vital, limit 1); adrenal gland: 10.6 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); stomach: 7.6 nTPM (protected, limit 3); salivary gland: 7.6 nTPM (protected, limit 3); spinal cord: 7.5 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); urinary bladder: 6.9 nTPM (protected, limit 3); thyroid gland: 6.9 nTPM (manageable, limit 5); midbrain: 6.8 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 3); colon: 6.2 nTPM (protected, limit 3); amygdala: 5.8 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IGFLR1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000126467,True,compatible,,True,True,True,,0.347436,0.3,0.249144,0,3,partial,1.4,0.9,1.7,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TSKS,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,True,True,True,True,False,unchanged,
ENSG00000126550,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 55.2083% (minimum 70%, Approved); pancreas: 22.7468% (minimum 70%, Approved); salivary gland: 0.0112% (minimum 65%, Approved)",0.283333,-0.649888,-0.472532,0,3,partial,18,47123.7,0.7,"salivary gland: 47123.7 nTPM (protected, limit 4); pancreas: 18 nTPM (vital, limit 2); heart muscle: 4.3 nTPM (vital, limit 2)",,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HTN1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000126752,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0.1,0.2,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SSX1,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000126787,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 36.5801% (minimum 75%, Missing); lymph node: 49.2711% (minimum 70%, Missing); thymus: 29.2388% (minimum 65%, Missing)",-0.357612,-0.207289,-0.384199,0,17,partial,29.3,17.4,40.9,"thymus: 40.9 nTPM (manageable, limit 5); bone marrow: 29.3 nTPM (vital, limit 1); lymph node: 17.4 nTPM (protected, limit 3); rectum: 6.5 nTPM (protected, limit 3); colon: 5.4 nTPM (protected, limit 3); esophagus: 5 nTPM (protected, limit 3); duodenum: 4.9 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DLGAP5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000126856,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRDM7,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000126890,True,compatible,,True,True,True,,0.126923,0.3,0.0644737,0,2,partial,5.1,0.8,2.9,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,False,LAGE-1 / NY-ESO family target with source-database CTA evidence; excluded from the strict default because HPA RNA has a low-level heart signal.,True,The historical categorical somatic-RNA holdback is superseded for this numerical research screen. Retention still requires every current RNA/selectivity/IHC/coverage gate; this adjudication cannot bypass a failing observation.,True,Pinned heart RNA 5.1 nTPM coexists with Enhanced Not detected cardiomyocyte IHC. Cell of origin and antigen presentation remain unresolved. Reviewed clinical cardiac events have confounding and uncertain attribution; no blanket cardiac-safety claim. Frozen core/extended policies retain their original holdback.,https://pirl-unc.github.io/oncoref/audits/ctag2-heart-evidence/,CTAG2,current_adaptive,True,True,True,False,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Seager 2024 · panel;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,True,False,gained,current_adaptive
ENSG00000127252,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 45.1735% (minimum 75%, Missing); tongue: 62.5874% (minimum 70%, Missing)",0.263265,-0.0741259,-0.298265,0,80,unavailable,86.9,42.8,6.8,"skeletal muscle: 86.9 nTPM (vital, limit 1); tongue: 42.8 nTPM (protected, limit 3); heart muscle: 9 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); basal ganglia: 6.4 nTPM (vital, limit 1); esophagus: 6.3 nTPM (protected, limit 3); hippocampal formation: 6.3 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PLAAT1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000127311,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.3333% (minimum 65%, Missing); adrenal gland: 72.7273% (minimum 75%, Missing); basal ganglia: 72.7273% (minimum 75%, Missing); bone marrow: 47.0588% (minimum 75%, Missing); colon: 53.3333% (minimum 70%, Missing); esophagus: 61.5385% (minimum 70%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); hippocampal formation: 72.7273% (minimum 75%, Missing); hypothalamus: 72.7273% (minimum 75%, Missing); kidney: 53.3333% (minimum 75%, Missing); liver: 40.0000% (minimum 75%, Missing); lung: 44.4444% (minimum 75%, Missing); lymph node: 61.5385% (minimum 70%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 50.0000% (minimum 75%, Missing); pituitary gland: 40.0000% (minimum 75%, Missing); salivary gland: 53.3333% (minimum 70%, Missing); skin: 61.5385% (minimum 65%, Missing); small intestine: 40.0000% (minimum 75%, Missing); spinal cord: 57.1429% (minimum 75%, Missing); spleen: 32.0000% (minimum 65%, Missing); stomach: 53.3333% (minimum 70%, Missing); thyroid gland: 53.3333% (minimum 65%, Missing); urinary bladder: 61.5385% (minimum 70%, Missing)",-0.33,-0.166667,-0.35,0,80,unavailable,1.2,0.7,1.7,"liver: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HELB,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000127337,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 44.3350% (minimum 75%, Missing); cerebellum: 68.4411% (minimum 75%, Missing); choroid plexus: 70.7269% (minimum 75%, Missing); duodenum: 73.3198% (minimum 75%, Missing); kidney: 70.8661% (minimum 75%, Missing); liver: 71.4286% (minimum 75%, Missing); lymph node: 62.0690% (minimum 70%, Missing); pancreas: 68.1818% (minimum 75%, Missing); retina: 64.9819% (minimum 75%, Missing); skeletal muscle: 72.2892% (minimum 75%, Missing); small intestine: 73.3198% (minimum 75%, Missing); thymus: 58.8235% (minimum 65%, Missing); tongue: 65.8135% (minimum 70%, Missing)",-0.0617647,-0.0793103,-0.30665,0,80,unavailable,45.2,22,25.2,"bone marrow: 45.2 nTPM (vital, limit 1); thymus: 25.2 nTPM (manageable, limit 5); lymph node: 22 nTPM (protected, limit 3); retina: 19.4 nTPM (vital, limit 1); tongue: 18.7 nTPM (protected, limit 3); pancreas: 16.8 nTPM (vital, limit 1); cerebellum: 16.6 nTPM (vital, limit 1); choroid plexus: 14.9 nTPM (vital, limit 1); kidney: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); skeletal muscle: 13.8 nTPM (vital, limit 1); thyroid gland: 13.4 nTPM (manageable, limit 5); rectum: 13.3 nTPM (protected, limit 3); duodenum: 13.1 nTPM (vital, limit 1); small intestine: 13.1 nTPM (vital, limit 1); colon: 11.9 nTPM (protected, limit 3); salivary gland: 11.7 nTPM (protected, limit 3); adrenal gland: 11.5 nTPM (vital, limit 1); esophagus: 11.3 nTPM (protected, limit 3); skin: 11 nTPM (manageable, limit 5); urinary bladder: 10.9 nTPM (protected, limit 3); parathyroid gland: 10.8 nTPM (protected, limit 3); stomach: 10.7 nTPM (protected, limit 3); heart muscle: 10.7 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); cerebral cortex: 10.6 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); pituitary gland: 9.9 nTPM (vital, limit 1); hypothalamus: 9.7 nTPM (vital, limit 1); adipose tissue: 9.1 nTPM (manageable, limit 5); midbrain: 8.9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); lung: 8.6 nTPM (vital, limit 1); smooth muscle: 8.1 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,YEATS4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000127423,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 71.7593% (minimum 75%, Missing)",0.272619,0.21716,-0.0324074,0,80,unavailable,6.1,1.4,1.3,"bone marrow: 6.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AUNIP,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000127540,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.6253% (minimum 65%, Missing); adrenal gland: 43.6139% (minimum 75%, Missing); amygdala: 30.0650% (minimum 75%, Missing); basal ganglia: 34.7801% (minimum 75%, Missing); bone marrow: 60.6458% (minimum 75%, Missing); cerebellum: 56.0112% (minimum 75%, Missing); cerebral cortex: 36.1178% (minimum 75%, Missing); choroid plexus: 38.6495% (minimum 75%, Missing); colon: 40.4169% (minimum 70%, Missing); duodenum: 50.9322% (minimum 75%, Missing); esophagus: 46.3377% (minimum 70%, Missing); heart muscle: 17.2552% (minimum 75%, Missing); hippocampal formation: 36.2923% (minimum 75%, Missing); hypothalamus: 41.8524% (minimum 75%, Missing); kidney: 37.3989% (minimum 75%, Missing); liver: 31.1238% (minimum 75%, Missing); lung: 56.0112% (minimum 75%, Missing); lymph node: 69.1600% (minimum 70%, Missing); midbrain: 31.8158% (minimum 75%, Missing); pancreas: 55.6481% (minimum 75%, Missing); parathyroid gland: 57.1293% (minimum 70%, Missing); pituitary gland: 49.6284% (minimum 75%, Missing); salivary gland: 53.4698% (minimum 70%, Missing); skeletal muscle: 16.6344% (minimum 75%, Missing); skin: 55.1376% (minimum 65%, Missing); small intestine: 49.7105% (minimum 75%, Missing); smooth muscle: 73.5618% (minimum 75%, Missing); spinal cord: 40.3898% (minimum 75%, Missing); spleen: 50.2508% (minimum 65%, Missing); stomach: 44.5185% (minimum 70%, Missing); thyroid gland: 54.0954% (minimum 65%, Missing); tongue: 36.2923% (minimum 70%, Missing); urinary bladder: 50.5042% (minimum 70%, Missing)",-0.183747,-0.337077,-0.583656,0,80,unavailable,301.2,105.5,68.8,"skeletal muscle: 301.2 nTPM (vital, limit 1); heart muscle: 288.2 nTPM (vital, limit 1); amygdala: 139.8 nTPM (vital, limit 1); liver: 133 nTPM (vital, limit 1); midbrain: 128.8 nTPM (vital, limit 1); basal ganglia: 112.7 nTPM (vital, limit 1); cerebral cortex: 106.3 nTPM (vital, limit 1); tongue: 105.5 nTPM (protected, limit 3); hippocampal formation: 105.5 nTPM (vital, limit 1); kidney: 100.6 nTPM (vital, limit 1); choroid plexus: 95.4 nTPM (vital, limit 1); spinal cord: 88.7 nTPM (vital, limit 1); colon: 88.6 nTPM (protected, limit 3); hypothalamus: 83.5 nTPM (vital, limit 1); adrenal gland: 77.7 nTPM (vital, limit 1); stomach: 74.9 nTPM (protected, limit 3); esophagus: 69.6 nTPM (protected, limit 3); adipose tissue: 68.8 nTPM (manageable, limit 5); pituitary gland: 61 nTPM (vital, limit 1); small intestine: 60.8 nTPM (vital, limit 1); spleen: 59.5 nTPM (manageable, limit 5); urinary bladder: 58.9 nTPM (protected, limit 3); duodenum: 57.9 nTPM (vital, limit 1); salivary gland: 52.3 nTPM (protected, limit 3); thyroid gland: 51 nTPM (manageable, limit 5); skin: 48.9 nTPM (manageable, limit 5); pancreas: 47.9 nTPM (vital, limit 1); lung: 47.2 nTPM (vital, limit 1); cerebellum: 47.2 nTPM (vital, limit 1); parathyroid gland: 45.1 nTPM (protected, limit 3); bone marrow: 39 nTPM (vital, limit 1); lymph node: 26.8 nTPM (protected, limit 3); thymus: 23.4 nTPM (manageable, limit 5); rectum: 22 nTPM (protected, limit 3); smooth muscle: 21.6 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,UQCR11,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000127564,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 66.9492% (minimum 75%, Missing)",0.206037,0.131579,-0.0805085,0,80,unavailable,27.3,11.2,9.3,"bone marrow: 27.3 nTPM (vital, limit 1); retina: 16.9 nTPM (vital, limit 1); esophagus: 11.2 nTPM (protected, limit 3); thymus: 9.3 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 3); spleen: 5.4 nTPM (manageable, limit 5); small intestine: 3.9 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); stomach: 3.2 nTPM (protected, limit 3); duodenum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PKMYT1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000127870,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.9919% (minimum 75%, Missing); amygdala: 70.5628% (minimum 75%, Missing); basal ganglia: 65.7258% (minimum 75%, Missing); bone marrow: 50.3864% (minimum 75%, Missing); cerebellum: 64.5545% (minimum 70%, Approved); cerebral cortex: 60.2588% (minimum 75%, Missing); colon: 64.6825% (minimum 70%, Missing); duodenum: 65.7258% (minimum 75%, Missing); esophagus: 64.5545% (minimum 65%, Approved); hippocampal formation: 71.0240% (minimum 75%, Missing); hypothalamus: 73.9229% (minimum 75%, Missing); kidney: 64.9402% (minimum 75%, Missing); liver: 66.9405% (minimum 70%, Approved); lung: 67.4948% (minimum 75%, Missing); lymph node: 59.8165% (minimum 65%, Approved); parathyroid gland: 60.1476% (minimum 70%, Missing); rectum: 64.5545% (minimum 70%, Missing); retina: 55.8219% (minimum 75%, Missing); skeletal muscle: 61.5094% (minimum 70%, Approved); small intestine: 64.0472% (minimum 75%, Missing); smooth muscle: 68.3438% (minimum 70%, Approved); spleen: 62.9344% (minimum 65%, Missing); stomach: 66.1258% (minimum 70%, Missing); thymus: 56.9930% (minimum 65%, Missing); tongue: 68.9218% (minimum 70%, Missing); urinary bladder: 64.8111% (minimum 70%, Missing)",-0.0800699,-0.098524,-0.246136,0,3,partial,32.1,21.9,24.6,"bone marrow: 32.1 nTPM (vital, limit 1); retina: 25.8 nTPM (vital, limit 1); thymus: 24.6 nTPM (manageable, limit 5); lymph node: 21.9 nTPM (protected, limit 4); parathyroid gland: 21.6 nTPM (protected, limit 3); cerebral cortex: 21.5 nTPM (vital, limit 1); skeletal muscle: 20.4 nTPM (vital, limit 2); spleen: 19.2 nTPM (manageable, limit 5); adipose tissue: 18.3 nTPM (manageable, limit 10); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 17.9 nTPM (vital, limit 2); esophagus: 17.9 nTPM (protected, limit 4); rectum: 17.9 nTPM (protected, limit 3); colon: 17.8 nTPM (protected, limit 3); urinary bladder: 17.7 nTPM (protected, limit 3); kidney: 17.6 nTPM (vital, limit 1); duodenum: 17 nTPM (vital, limit 1); basal ganglia: 17 nTPM (vital, limit 1); skin: 16.9 nTPM (manageable, limit 5); thyroid gland: 16.9 nTPM (manageable, limit 10); adrenal gland: 16.8 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 3); liver: 16.1 nTPM (vital, limit 2); lung: 15.7 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 2); tongue: 14.7 nTPM (protected, limit 3); pancreas: 13.7 nTPM (vital, limit 2); amygdala: 13.6 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 2); salivary gland: 13.1 nTPM (protected, limit 4); hypothalamus: 11.5 nTPM (vital, limit 1); pituitary gland: 10.5 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); midbrain: 10.3 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RNF6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000127928,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 20.1439% (minimum 75%, Missing); retina: 0.1517% (minimum 75%, Missing)",0.315517,0.265517,-0.748483,0,0,routine_complete,1842.8,0.4,0.1,"retina: 1842.8 nTPM (vital, limit 1); choroid plexus: 11.1 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GNGT1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000127993,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0230% (minimum 65%, Uncertain); adrenal gland: 53.1073% (minimum 75%, Missing); amygdala: 48.9583% (minimum 75%, Missing); basal ganglia: 44.1315% (minimum 75%, Missing); bone marrow: 40.5172% (minimum 75%, Missing); cerebellum: 40.1709% (minimum 75%, Missing); cerebral cortex: 41.9643% (minimum 75%, Missing); choroid plexus: 67.6259% (minimum 75%, Missing); colon: 54.6512% (minimum 70%, Missing); duodenum: 64.3836% (minimum 75%, Missing); esophagus: 55.9524% (minimum 70%, Missing); heart muscle: 49.2147% (minimum 75%, Missing); hippocampal formation: 43.1193% (minimum 75%, Missing); hypothalamus: 45.8537% (minimum 75%, Missing); kidney: 56.6265% (minimum 75%, Missing); liver: 51.6484% (minimum 75%, Missing); lung: 60.2564% (minimum 75%, Missing); lymph node: 53.4091% (minimum 70%, Missing); midbrain: 42.9224% (minimum 75%, Missing); pancreas: 53.4091% (minimum 75%, Missing); parathyroid gland: 67.6259% (minimum 70%, Missing); pituitary gland: 56.2874% (minimum 75%, Missing); rectum: 67.6259% (minimum 70%, Missing); retina: 59.8726% (minimum 75%, Missing); salivary gland: 53.7143% (minimum 70%, Missing); skeletal muscle: 41.9643% (minimum 75%, Missing); skin: 54.6512% (minimum 65%, Missing); small intestine: 51.9337% (minimum 75%, Missing); smooth muscle: 72.8682% (minimum 75%, Missing); spinal cord: 40.0000% (minimum 75%, Missing); spleen: 45.8537% (minimum 65%, Missing); stomach: 54.9708% (minimum 70%, Missing); thymus: 59.4937% (minimum 65%, Missing); thyroid gland: 53.7143% (minimum 65%, Missing); tongue: 58.3851% (minimum 70%, Missing); urinary bladder: 56.9697% (minimum 70%, Missing)",-0.191463,-0.165909,-0.35,0,1,partial,14.1,8.2,11.1,"spinal cord: 14.1 nTPM (vital, limit 1); cerebellum: 14 nTPM (vital, limit 1); bone marrow: 13.8 nTPM (vital, limit 1); skeletal muscle: 13 nTPM (vital, limit 1); cerebral cortex: 13 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 12.4 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); spleen: 11.1 nTPM (manageable, limit 5); hypothalamus: 11.1 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); heart muscle: 9.7 nTPM (vital, limit 1); liver: 8.8 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); pancreas: 8.2 nTPM (vital, limit 1); lymph node: 8.2 nTPM (protected, limit 3); thyroid gland: 8.1 nTPM (manageable, limit 5); salivary gland: 8.1 nTPM (protected, limit 3); adipose tissue: 8 nTPM (manageable, limit 5); skin: 7.8 nTPM (manageable, limit 5); colon: 7.8 nTPM (protected, limit 3); stomach: 7.7 nTPM (protected, limit 3); esophagus: 7.4 nTPM (protected, limit 3); pituitary gland: 7.3 nTPM (vital, limit 1); kidney: 7.2 nTPM (vital, limit 1); urinary bladder: 7.1 nTPM (protected, limit 3); tongue: 6.7 nTPM (protected, limit 3); thymus: 6.4 nTPM (manageable, limit 5); retina: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 3); rectum: 4.5 nTPM (protected, limit 3); choroid plexus: 4.5 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RBM48,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000128040,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349259,0.299571,0.248188,0,1,partial,13.1,4.6,3.8,"bone marrow: 13.1 nTPM (vital, limit 6); choroid plexus: 9.3 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 6); pituitary gland: 4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPINK2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000128059,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 58.7413% (minimum 75%, Missing); amygdala: 71.7949% (minimum 75%, Missing); basal ganglia: 71.1864% (minimum 75%, Missing); bone marrow: 60.4317% (minimum 70%, Approved); cerebellum: 68.8525% (minimum 70%, Approved); cerebral cortex: 60.4317% (minimum 75%, Missing); choroid plexus: 70.5882% (minimum 75%, Missing); colon: 68.8525% (minimum 70%, Missing); duodenum: 68.2927% (minimum 75%, Missing); esophagus: 66.1417% (minimum 70%, Missing); hippocampal formation: 73.6842% (minimum 75%, Missing); hypothalamus: 71.1864% (minimum 75%, Missing); kidney: 59.1549% (minimum 75%, Missing); liver: 58.3333% (minimum 75%, Missing); lymph node: 50.6024% (minimum 70%, Missing); midbrain: 70.5882% (minimum 75%, Missing); pancreas: 59.5745% (minimum 75%, Missing); rectum: 64.6154% (minimum 70%, Missing); retina: 66.1417% (minimum 75%, Missing); salivary gland: 60.4317% (minimum 70%, Missing); small intestine: 73.0435% (minimum 75%, Missing); thymus: 50.9091% (minimum 65%, Missing); thyroid gland: 59.1549% (minimum 60%, Approved); urinary bladder: 56.3758% (minimum 65%, Approved)",-0.140909,-0.193976,-0.166667,0,3,partial,6,8.2,8.1,"lymph node: 8.2 nTPM (protected, limit 3); thymus: 8.1 nTPM (manageable, limit 5); urinary bladder: 6.5 nTPM (protected, limit 4); liver: 6 nTPM (vital, limit 1); adrenal gland: 5.9 nTPM (vital, limit 1); kidney: 5.8 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); bone marrow: 5.5 nTPM (vital, limit 2); rectum: 4.6 nTPM (protected, limit 3); esophagus: 4.3 nTPM (protected, limit 3); retina: 4.3 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); cerebellum: 3.8 nTPM (vital, limit 2); stomach: 3.5 nTPM (protected, limit 3); smooth muscle: 3.5 nTPM (vital, limit 2); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); skeletal muscle: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PPAT,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000128271,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 50.4762% (minimum 60%, Enhanced); amygdala: 43.8017% (minimum 75%, Missing); basal ganglia: 4.5572% (minimum 75%, Missing); bone marrow: 11.6740% (minimum 75%, Missing); cerebellum: 35.0993% (minimum 75%, Missing); cerebral cortex: 40.7692% (minimum 60%, Enhanced); choroid plexus: 73.6111% (minimum 75%, Missing); colon: 56.9892% (minimum 70%, Missing); duodenum: 45.2991% (minimum 75%, Missing); heart muscle: 28.8043% (minimum 60%, Enhanced); hippocampal formation: 39.5522% (minimum 75%, Missing); hypothalamus: 42.7419% (minimum 75%, Missing); kidney: 23.8739% (minimum 75%, Missing); liver: 27.1795% (minimum 60%, Enhanced); lung: 27.3196% (minimum 60%, Enhanced); lymph node: 20.9486% (minimum 70%, Missing); midbrain: 41.4062% (minimum 75%, Missing); pituitary gland: 44.9153% (minimum 75%, Missing); retina: 72.6027% (minimum 75%, Missing); small intestine: 43.8017% (minimum 75%, Missing); spinal cord: 54.0816% (minimum 75%, Missing); spleen: 26.3682% (minimum 50%, Enhanced); thymus: 9.1379% (minimum 65%, Missing); urinary bladder: 50.9615% (minimum 55%, Enhanced)",-0.558621,-0.490514,-0.704428,0,15,partial,111,20,52.7,"basal ganglia: 111 nTPM (vital, limit 1); thymus: 52.7 nTPM (manageable, limit 5); bone marrow: 40.1 nTPM (vital, limit 1); lymph node: 20 nTPM (protected, limit 3); kidney: 16.9 nTPM (vital, limit 1); liver: 14.2 nTPM (vital, limit 6); lung: 14.1 nTPM (vital, limit 6); heart muscle: 13.1 nTPM (vital, limit 6); cerebellum: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 6); midbrain: 7.5 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); retina: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); caudate / neuronal projections: High (Enhanced); caudate / synapses: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); thymus / cortical cells: Medium (Enhanced); thymus / medullary cells: Medium (Enhanced),94,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ADORA2A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000128322,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 26.1194% (minimum 75%, Missing)",0.0622093,0.3,-0.488806,0,2,partial,69.3,1.6,9.9,"bone marrow: 69.3 nTPM (vital, limit 1); thymus: 9.9 nTPM (manageable, limit 5)",bone marrow / hematopoietic cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IGLL1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000128346,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.136441,0.173001,0.145753,0,80,unavailable,10.8,13.5,25.2,"skin: 25.2 nTPM (manageable, limit 5); esophagus: 13.5 nTPM (protected, limit 3); choroid plexus: 10.8 nTPM (vital, limit 1); salivary gland: 10 nTPM (protected, limit 3); stomach: 8.7 nTPM (protected, limit 3); pancreas: 8.3 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); cerebral cortex: 7.2 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 3); skeletal muscle: 5.5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); retina: 3.4 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 3); bone marrow: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C22orf23,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000128394,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 58.5034% (minimum 75%, Missing); bone marrow: 73.5043% (minimum 75%, Missing); choroid plexus: 59.3103% (minimum 75%, Missing); duodenum: 71.0744% (minimum 75%, Missing); heart muscle: 61.8705% (minimum 75%, Missing); kidney: 72.2689% (minimum 75%, Missing); lung: 72.2689% (minimum 75%, Missing); lymph node: 36.1345% (minimum 70%, Missing); pancreas: 74.7826% (minimum 75%, Missing); parathyroid gland: 63.2353% (minimum 70%, Missing); pituitary gland: 72.2689% (minimum 75%, Missing); salivary gland: 64.6617% (minimum 70%, Missing); small intestine: 69.9187% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spleen: 42.5743% (minimum 65%, Missing); stomach: 65.1515% (minimum 70%, Missing); thymus: 62.3188% (minimum 65%, Missing); urinary bladder: 66.1538% (minimum 70%, Missing)",-0.224257,-0.338655,-0.164966,0,80,unavailable,6.1,15.2,11.6,"lymph node: 15.2 nTPM (protected, limit 3); spleen: 11.6 nTPM (manageable, limit 5); adrenal gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); heart muscle: 5.3 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); parathyroid gland: 5 nTPM (protected, limit 3); salivary gland: 4.7 nTPM (protected, limit 3); stomach: 4.6 nTPM (protected, limit 3); urinary bladder: 4.4 nTPM (protected, limit 3); smooth muscle: 4.3 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); colon: 3.3 nTPM (protected, limit 3); bone marrow: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,APOBEC3F,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000128408,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 69.6262% (minimum 75%, Missing)",0.333498,0.3,-0.0537383,0,11,partial,13,1.2,0.9,"choroid plexus: 13 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RIBC2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000128487,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.7230% (minimum 65%, Missing); adrenal gland: 70.4762% (minimum 75%, Missing); amygdala: 51.0345% (minimum 75%, Missing); basal ganglia: 52.4823% (minimum 75%, Missing); bone marrow: 49.2239% (minimum 75%, Missing); cerebellum: 67.2727% (minimum 75%, Missing); cerebral cortex: 50.2262% (minimum 75%, Missing); choroid plexus: 38.0137% (minimum 75%, Missing); colon: 60.4905% (minimum 70%, Missing); duodenum: 70.0315% (minimum 75%, Missing); hippocampal formation: 46.3466% (minimum 75%, Missing); hypothalamus: 55.5000% (minimum 75%, Missing); midbrain: 44.8485% (minimum 75%, Missing); small intestine: 68.7307% (minimum 75%, Missing); smooth muscle: 71.1538% (minimum 75%, Missing); spinal cord: 38.4749% (minimum 75%, Missing); spleen: 63.0682% (minimum 65%, Missing); stomach: 68.9441% (minimum 70%, Missing)",-0.0193182,-0.0950954,-0.369863,0,6,partial,36.2,14.5,13,"choroid plexus: 36.2 nTPM (vital, limit 1); spinal cord: 35.5 nTPM (vital, limit 1); midbrain: 27.3 nTPM (vital, limit 1); hippocampal formation: 25.7 nTPM (vital, limit 1); bone marrow: 22.9 nTPM (vital, limit 1); cerebral cortex: 22 nTPM (vital, limit 1); amygdala: 21.3 nTPM (vital, limit 1); basal ganglia: 20.1 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); colon: 14.5 nTPM (protected, limit 3); spleen: 13 nTPM (manageable, limit 5); adipose tissue: 12.1 nTPM (manageable, limit 5); cerebellum: 10.8 nTPM (vital, limit 1); small intestine: 10.1 nTPM (vital, limit 1); stomach: 10 nTPM (protected, limit 3); duodenum: 9.5 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 3); adrenal gland: 9.3 nTPM (vital, limit 1); smooth muscle: 9 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 3); pituitary gland: 6.2 nTPM (vital, limit 1); salivary gland: 6 nTPM (protected, limit 3); retina: 5.7 nTPM (vital, limit 1); lung: 5.6 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); skeletal muscle: 4.8 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); urinary bladder: 4.4 nTPM (protected, limit 3)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPECC1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000128596,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 67.8827% (minimum 75%, Missing); cerebral cortex: 73.1361% (minimum 75%, Missing)",0.322522,0.279381,-0.0711734,0,7,partial,85.4,19.5,5.1,"cerebellum: 85.4 nTPM (vital, limit 1); cerebral cortex: 66.3 nTPM (vital, limit 1); retina: 50.9 nTPM (vital, limit 1); hypothalamus: 46.2 nTPM (vital, limit 1); midbrain: 34 nTPM (vital, limit 1); hippocampal formation: 29.7 nTPM (vital, limit 1); amygdala: 26.9 nTPM (vital, limit 1); colon: 19.5 nTPM (protected, limit 12); spinal cord: 19 nTPM (vital, limit 1); basal ganglia: 18.5 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 12); smooth muscle: 11.2 nTPM (vital, limit 6); pituitary gland: 6.3 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); choroid plexus: 4.8 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 3)",caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC136,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000128610,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 60.2740% (minimum 75%, Missing); basal ganglia: 55.0000% (minimum 75%, Missing); hypothalamus: 24.7191% (minimum 75%, Missing); midbrain: 68.7500% (minimum 75%, Missing); pituitary gland: 60.2740% (minimum 75%, Missing); retina: 64.7059% (minimum 75%, Missing)",0.35,0.3,-0.502809,0,2,partial,13.4,0,0.1,"hypothalamus: 13.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / neuronal cells: Low (Approved); hypothalamus / neuronal cells: Low (Approved); hypothalamus / neuronal projections: Medium (Approved),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FEZF1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000128655,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"liver: 46.4912% (minimum 75%, Missing); parathyroid gland: 34.8684% (minimum 70%, Missing); skeletal muscle: 55.7895% (minimum 75%, Missing); spinal cord: 65.4321% (minimum 75%, Missing)",0.0566667,-0.351316,-0.285088,0,3,partial,6.1,9.9,2.2,"parathyroid gland: 9.9 nTPM (protected, limit 3); liver: 6.1 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PDE11A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000128886,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 51.8868% (minimum 75%, Missing); duodenum: 49.6988% (minimum 75%, Missing); lymph node: 24.7748% (minimum 70%, Missing); rectum: 58.0986% (minimum 70%, Missing); skin: 39.0071% (minimum 65%, Missing); small intestine: 52.8846% (minimum 70%, Approved)",-0.259929,-0.452252,-0.253012,0,4,partial,16.7,50.1,25.8,"lymph node: 50.1 nTPM (protected, limit 3); skin: 25.8 nTPM (manageable, limit 5); duodenum: 16.7 nTPM (vital, limit 1); choroid plexus: 15.3 nTPM (vital, limit 1); small intestine: 14.7 nTPM (vital, limit 2); rectum: 11.9 nTPM (protected, limit 3); colon: 8.3 nTPM (protected, limit 4); esophagus: 4.8 nTPM (protected, limit 4); cerebellum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); lymph node / germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ELL3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000129221,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 75.0000% (minimum 75%, Missing); bone marrow: 46.1538% (minimum 60%, Enhanced); choroid plexus: 13.9535% (minimum 75%, Missing); retina: 0.0740% (minimum 75%, Missing)",0.0454545,0.05,-0.74926,0,1,partial,810,0.4,0.5,"retina: 810 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AIPL1,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000129535,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 53.2468% (minimum 75%, Missing); basal ganglia: 52.5641% (minimum 75%, Missing); cerebral cortex: 55.4054% (minimum 60%, Enhanced); hippocampal formation: 56.9444% (minimum 75%, Missing); hypothalamus: 61.1940% (minimum 75%, Missing); kidney: 57.7465% (minimum 60%, Enhanced); liver: 53.9474% (minimum 60%, Enhanced); midbrain: 54.6667% (minimum 75%, Missing); pituitary gland: 64.0625% (minimum 75%, Missing); retina: 1.3175% (minimum 75%, Missing); spinal cord: 52.5641% (minimum 75%, Missing)",0.123585,0.0592593,-0.736825,0,1,partial,307.1,1.9,2.3,"retina: 307.1 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NRL,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000129559,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.2442% (minimum 65%, Missing); adrenal gland: 41.2385% (minimum 75%, Missing); amygdala: 38.9527% (minimum 75%, Missing); basal ganglia: 37.5154% (minimum 75%, Missing); bone marrow: 62.9385% (minimum 75%, Missing); cerebellum: 50.5302% (minimum 75%, Missing); cerebral cortex: 34.7301% (minimum 75%, Missing); choroid plexus: 46.4231% (minimum 75%, Missing); colon: 47.7159% (minimum 70%, Missing); duodenum: 73.7784% (minimum 75%, Missing); esophagus: 43.7088% (minimum 70%, Missing); heart muscle: 34.4477% (minimum 75%, Missing); hippocampal formation: 42.5502% (minimum 75%, Missing); hypothalamus: 40.9726% (minimum 75%, Missing); kidney: 44.4736% (minimum 75%, Missing); liver: 47.0970% (minimum 75%, Missing); lung: 51.5725% (minimum 75%, Missing); lymph node: 65.8463% (minimum 70%, Missing); midbrain: 41.3503% (minimum 75%, Missing); pancreas: 58.6088% (minimum 75%, Missing); parathyroid gland: 35.3582% (minimum 70%, Missing); pituitary gland: 52.1189% (minimum 75%, Missing); rectum: 64.0218% (minimum 70%, Missing); retina: 67.8683% (minimum 75%, Missing); salivary gland: 53.0250% (minimum 70%, Missing); skeletal muscle: 34.9450% (minimum 75%, Missing); skin: 46.3808% (minimum 65%, Missing); small intestine: 54.9154% (minimum 75%, Missing); smooth muscle: 61.8661% (minimum 75%, Missing); spinal cord: 47.5819% (minimum 75%, Missing); spleen: 48.7065% (minimum 65%, Missing); stomach: 51.7124% (minimum 70%, Missing); thymus: 55.4949% (minimum 65%, Missing); thyroid gland: 54.2126% (minimum 65%, Missing); tongue: 44.6167% (minimum 70%, Missing); urinary bladder: 50.9182% (minimum 70%, Missing)",-0.186192,-0.346418,-0.405523,0,0,routine_complete,290.2,278.8,176.3,"heart muscle: 290.2 nTPM (vital, limit 1); cerebral cortex: 286.6 nTPM (vital, limit 1); skeletal muscle: 283.9 nTPM (vital, limit 1); parathyroid gland: 278.8 nTPM (protected, limit 3); basal ganglia: 254 nTPM (vital, limit 1); amygdala: 239 nTPM (vital, limit 1); hypothalamus: 219.7 nTPM (vital, limit 1); adrenal gland: 217.3 nTPM (vital, limit 1); midbrain: 216.3 nTPM (vital, limit 1); hippocampal formation: 205.9 nTPM (vital, limit 1); esophagus: 196.4 nTPM (protected, limit 3); kidney: 190.4 nTPM (vital, limit 1); tongue: 189.3 nTPM (protected, limit 3); skin: 176.3 nTPM (manageable, limit 5); choroid plexus: 176 nTPM (vital, limit 1); liver: 171.3 nTPM (vital, limit 1); spinal cord: 168 nTPM (vital, limit 1); colon: 167.1 nTPM (protected, limit 3); adipose tissue: 163.6 nTPM (manageable, limit 5); spleen: 160.6 nTPM (manageable, limit 5); cerebellum: 149.3 nTPM (vital, limit 1); urinary bladder: 147 nTPM (protected, limit 3); lung: 143.2 nTPM (vital, limit 1); stomach: 142.4 nTPM (protected, limit 3); pituitary gland: 140.1 nTPM (vital, limit 1); salivary gland: 135.1 nTPM (protected, limit 3); thyroid gland: 128.8 nTPM (manageable, limit 5); small intestine: 125.2 nTPM (vital, limit 1); thymus: 122.3 nTPM (manageable, limit 5); pancreas: 107.7 nTPM (vital, limit 1); smooth muscle: 94 nTPM (vital, limit 1); bone marrow: 89.8 nTPM (vital, limit 1); rectum: 85.7 nTPM (protected, limit 3); lymph node: 79.1 nTPM (protected, limit 3); retina: 72.2 nTPM (vital, limit 1); duodenum: 54.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NEDD8,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000129646,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308219,0.272527,0.09689,0,2,partial,7.3,3.4,4.2,"cerebellum: 7.3 nTPM (vital, limit 6); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,QRICH2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000129673,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 65.2174% (minimum 75%, Missing); retina: 29.8013% (minimum 75%, Missing)",0.125862,0.05,-0.451987,0,80,unavailable,10.6,1.5,1.3,"retina: 10.6 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AANAT,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000129810,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 43.0464% (minimum 60%, Enhanced); duodenum: 74.7126% (minimum 75%, Missing); lymph node: 51.5873% (minimum 70%, Missing); small intestine: 73.0337% (minimum 75%, Missing); thymus: 34.0314% (minimum 65%, Missing)",-0.309686,-0.184127,-0.169536,0,9,partial,8.6,6.1,12.6,"thymus: 12.6 nTPM (manageable, limit 5); bone marrow: 8.6 nTPM (vital, limit 6); lymph node: 6.1 nTPM (protected, limit 3); small intestine: 2.4 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1)",colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; appendix / germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SGO1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000129862,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,VCY1B,current_adaptive,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000129864,True,compatible,,True,True,True,,0.35,0.3,0.25,0,7,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,VCY,current_adaptive,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000129873,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CDY2B,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000130167,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.245437,0,3,partial,5.1,0.1,0.2,,adrenal gland / glandular cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TSPAN16,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000130234,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 21.3000% (minimum 75%, Missing); heart muscle: 54.0089% (minimum 60%, Enhanced); kidney: 36.2752% (minimum 75%, Missing); small intestine: 16.9344% (minimum 75%, Missing)",0.339796,0.134768,-0.580656,0,12,partial,237.9,9.6,8.6,"small intestine: 237.9 nTPM (vital, limit 1); duodenum: 179.2 nTPM (vital, limit 1); kidney: 85.2 nTPM (vital, limit 1); heart muscle: 41.3 nTPM (vital, limit 6); colon: 9.6 nTPM (protected, limit 3); rectum: 5.8 nTPM (protected, limit 3); choroid plexus: 5.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); kidney / bowman's capsule: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),89,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ACE2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000130270,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.219388,0.268182,0.0359779,0,80,unavailable,5.8,0.7,3.2,"bone marrow: 5.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ATP8B3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000130377,True,compatible,,True,True,True,,0.35,0.3,0.246823,0,1,partial,0.5,0.1,0.2,,,54,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ACSBG2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000130383,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 28.5714% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing)",0.35,-0.0333333,-0.464286,0,80,unavailable,0.5,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FUT5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000130385,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,BMP15,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000130518,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.318198,0.3,0.13961,0,9,partial,3.4,1.1,2.4,"choroid plexus: 3.4 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",cerebellum / Bergmann glia - nucleus: High (Enhanced); cerebellum / GLUC cells - nucleus: Low (Enhanced); cerebellum / Purkinje cells - nucleus: High (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IQCN,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000130544,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.3333% (minimum 65%, Missing); adrenal gland: 52.5000% (minimum 75%, Missing); amygdala: 67.7419% (minimum 75%, Missing); basal ganglia: 65.6250% (minimum 75%, Missing); bone marrow: 36.2069% (minimum 75%, Missing); cerebellum: 51.2195% (minimum 75%, Missing); cerebral cortex: 53.8462% (minimum 75%, Missing); choroid plexus: 72.4138% (minimum 75%, Missing); colon: 58.3333% (minimum 70%, Missing); duodenum: 65.6250% (minimum 75%, Missing); esophagus: 55.2632% (minimum 70%, Missing); heart muscle: 63.6364% (minimum 75%, Missing); hippocampal formation: 63.6364% (minimum 75%, Missing); hypothalamus: 65.6250% (minimum 75%, Missing); kidney: 55.2632% (minimum 75%, Missing); liver: 50.0000% (minimum 75%, Missing); lung: 61.7647% (minimum 75%, Missing); lymph node: 45.6522% (minimum 70%, Missing); midbrain: 67.7419% (minimum 75%, Missing); pancreas: 55.2632% (minimum 75%, Missing); parathyroid gland: 55.2632% (minimum 70%, Missing); pituitary gland: 58.3333% (minimum 75%, Missing); rectum: 61.7647% (minimum 70%, Missing); retina: 55.2632% (minimum 75%, Missing); salivary gland: 60.0000% (minimum 70%, Missing); skeletal muscle: 61.7647% (minimum 75%, Missing); skin: 52.5000% (minimum 65%, Missing); small intestine: 56.7568% (minimum 75%, Missing); smooth muscle: 58.3333% (minimum 75%, Missing); spinal cord: 63.6364% (minimum 75%, Missing); spleen: 47.7273% (minimum 65%, Missing); stomach: 55.2632% (minimum 70%, Missing); thymus: 47.7273% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); tongue: 67.7419% (minimum 70%, Missing); urinary bladder: 58.3333% (minimum 70%, Missing)",-0.172727,-0.243478,-0.387931,0,80,unavailable,3.7,2.5,2.3,"bone marrow: 3.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF557,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000130561,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 44.7761% (minimum 75%, Missing); retina: 0.2106% (minimum 75%, Missing)",0.35,0.3,-0.747894,0,5,partial,1421.5,0,0.1,"retina: 1421.5 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),57,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SAG,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000130656,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 64.5455% (minimum 75%, Missing)",0.309459,0.3,-0.104545,0,2,partial,3.9,0.2,0.6,"bone marrow: 3.9 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; spleen / cells in red pulp,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HBZ,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000130783,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347067,0.295608,0.229827,0,2,partial,1.4,0.3,0.5,"retina: 1.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC62,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000130810,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.9340% (minimum 65%, Missing); adrenal gland: 50.1259% (minimum 75%, Missing); amygdala: 62.3824% (minimum 75%, Missing); basal ganglia: 60.6707% (minimum 75%, Missing); bone marrow: 63.3758% (minimum 75%, Missing); cerebellum: 54.0761% (minimum 75%, Missing); cerebral cortex: 57.0201% (minimum 75%, Missing); choroid plexus: 59.2262% (minimum 75%, Missing); colon: 52.3684% (minimum 70%, Missing); duodenum: 62.7760% (minimum 75%, Missing); esophagus: 42.4307% (minimum 70%, Missing); heart muscle: 53.7838% (minimum 75%, Missing); hippocampal formation: 60.4863% (minimum 75%, Missing); hypothalamus: 62.7760% (minimum 75%, Missing); kidney: 52.0942% (minimum 75%, Missing); liver: 45.4338% (minimum 75%, Missing); lung: 58.0175% (minimum 75%, Missing); lymph node: 53.6388% (minimum 70%, Missing); midbrain: 64.6104% (minimum 75%, Missing); pancreas: 46.9340% (minimum 75%, Missing); pituitary gland: 59.7598% (minimum 75%, Missing); salivary gland: 55.1247% (minimum 70%, Missing); skeletal muscle: 38.6408% (minimum 75%, Missing); skin: 42.1610% (minimum 65%, Missing); small intestine: 50.6361% (minimum 75%, Missing); spinal cord: 65.2459% (minimum 75%, Missing); spleen: 43.4498% (minimum 65%, Missing); stomach: 52.7851% (minimum 70%, Missing); thyroid gland: 56.2147% (minimum 65%, Missing); tongue: 65.6766% (minimum 70%, Missing); urinary bladder: 50.1259% (minimum 70%, Missing)",-0.22839,-0.275693,-0.363592,0,3,partial,31.6,27,27.3,"skeletal muscle: 31.6 nTPM (vital, limit 1); skin: 27.3 nTPM (manageable, limit 5); esophagus: 27 nTPM (protected, limit 3); spleen: 25.9 nTPM (manageable, limit 5); liver: 23.9 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); pancreas: 22.5 nTPM (vital, limit 1); adrenal gland: 19.8 nTPM (vital, limit 1); urinary bladder: 19.8 nTPM (protected, limit 3); small intestine: 19.4 nTPM (vital, limit 1); kidney: 18.3 nTPM (vital, limit 1); colon: 18.1 nTPM (protected, limit 3); stomach: 17.8 nTPM (protected, limit 3); lymph node: 17.2 nTPM (protected, limit 3); heart muscle: 17.1 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); salivary gland: 16.2 nTPM (protected, limit 3); thyroid gland: 15.5 nTPM (manageable, limit 5); cerebral cortex: 15 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); choroid plexus: 13.7 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); basal ganglia: 12.9 nTPM (vital, limit 1); amygdala: 12 nTPM (vital, limit 1); hypothalamus: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); bone marrow: 11.5 nTPM (vital, limit 1); midbrain: 10.9 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 3); thymus: 9.6 nTPM (manageable, limit 5); parathyroid gland: 8 nTPM (protected, limit 3); smooth muscle: 6.4 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 3); retina: 4.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PPAN,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000130943,True,compatible,,True,True,True,,0.35,0.270588,0.192857,0,5,partial,0.3,0.1,0.5,,,52,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PKDREJ,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000130948,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.286344,0.297207,0.106931,0,1,partial,14.8,2.6,9.7,"liver: 14.8 nTPM (vital, limit 6); spinal cord: 5 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HSD17B3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000130950,True,compatible,,True,True,True,,0.35,0.3,0.197368,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NUTM2F,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,True,True,True,True,gained,selectivity_revised
ENSG00000131019,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skeletal muscle: 49.1935% (minimum 70%, Approved); thyroid gland: 55.9633% (minimum 60%, Approved)",-0.040367,0.0721519,-0.208065,0,2,partial,6.3,1.8,4.8,"skeletal muscle: 6.3 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 2 / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ULBP3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000131044,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 68.9655% (minimum 75%, Missing); choroid plexus: 28.5714% (minimum 75%, Missing); hippocampal formation: 70.5882% (minimum 75%, Missing); hypothalamus: 69.7674% (minimum 75%, Missing); spinal cord: 72.2892% (minimum 75%, Missing)",0.259091,0.209091,-0.464286,0,80,unavailable,15,0.6,0.6,"choroid plexus: 15 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TTLL9,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000131050,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 51.8987% (minimum 60%, Enhanced); salivary gland: 0.0615% (minimum 70%, Missing)",0.35,-0.699385,-0.0810127,0,5,partial,3.8,6665.1,0.3,"salivary gland: 6665.1 nTPM (protected, limit 3)",salivary gland / glandular cells: High (Enhanced),53,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; salivary gland / glandular cells; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BPIFA2,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000131059,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BPIFA3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000131068,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,DEFB118,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000131115,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 63.2530% (minimum 65%, Uncertain); adrenal gland: 61.0465% (minimum 75%, Uncertain); amygdala: 60.3448% (minimum 75%, Missing); basal ganglia: 61.7647% (minimum 75%, Missing); bone marrow: 68.1818% (minimum 75%, Missing); cerebellum: 51.7241% (minimum 75%, Missing); cerebral cortex: 61.4035% (minimum 75%, Missing); choroid plexus: 66.4557% (minimum 75%, Missing); colon: 61.0465% (minimum 70%, Missing); duodenum: 66.4557% (minimum 75%, Missing); esophagus: 62.1302% (minimum 70%, Missing); heart muscle: 65.6250% (minimum 75%, Missing); hippocampal formation: 60.6936% (minimum 75%, Missing); hypothalamus: 61.0465% (minimum 75%, Missing); kidney: 61.0465% (minimum 75%, Missing); liver: 59.3220% (minimum 75%, Missing); lung: 64.0244% (minimum 75%, Missing); lymph node: 50.9709% (minimum 70%, Uncertain); midbrain: 57.6923% (minimum 75%, Missing); pancreas: 62.1302% (minimum 75%, Missing); parathyroid gland: 51.2195% (minimum 70%, Missing); pituitary gland: 57.3770% (minimum 75%, Missing); rectum: 65.2174% (minimum 70%, Missing); retina: 55.2632% (minimum 75%, Missing); salivary gland: 66.0377% (minimum 70%, Missing); skeletal muscle: 62.8743% (minimum 75%, Uncertain); skin: 62.5000% (minimum 65%, Missing); small intestine: 65.2174% (minimum 75%, Missing); smooth muscle: 61.7647% (minimum 75%, Uncertain); spinal cord: 56.1497% (minimum 75%, Missing); spleen: 53.2995% (minimum 65%, Missing); stomach: 55.5556% (minimum 70%, Missing); thymus: 38.6029% (minimum 65%, Missing); thyroid gland: 56.7568% (minimum 65%, Missing); tongue: 62.8743% (minimum 70%, Missing); urinary bladder: 60.3448% (minimum 70%, Missing)",-0.263971,-0.190291,-0.232759,0,1,partial,9.8,10.1,16.7,"thymus: 16.7 nTPM (manageable, limit 5); lymph node: 10.1 nTPM (protected, limit 3); parathyroid gland: 10 nTPM (protected, limit 3); cerebellum: 9.8 nTPM (vital, limit 1); spleen: 9.2 nTPM (manageable, limit 5); retina: 8.5 nTPM (vital, limit 1); stomach: 8.4 nTPM (protected, limit 3); spinal cord: 8.2 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); pituitary gland: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 1); urinary bladder: 6.9 nTPM (protected, limit 3); amygdala: 6.9 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); adrenal gland: 6.7 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 3); kidney: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); pancreas: 6.4 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 3); skin: 6.3 nTPM (manageable, limit 5); tongue: 6.2 nTPM (protected, limit 3); skeletal muscle: 6.2 nTPM (vital, limit 1); adipose tissue: 6.1 nTPM (manageable, limit 5); lung: 5.9 nTPM (vital, limit 1); small intestine: 5.6 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 3); heart muscle: 5.5 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 3); choroid plexus: 5.3 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF227,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000131126,True,compatible,,True,True,True,,0.341334,0.298255,0.25,0,6,partial,1.5,1.2,1.5,,,49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX101,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,False,unchanged,
ENSG00000131379,True,compatible,,True,True,True,,0.334615,0.269697,0.191176,0,80,unavailable,0.4,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C3orf20,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000131495,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.3585% (minimum 65%, Missing); adrenal gland: 38.4615% (minimum 75%, Missing); amygdala: 38.3474% (minimum 75%, Missing); basal ganglia: 39.3002% (minimum 75%, Missing); bone marrow: 45.0320% (minimum 75%, Missing); cerebellum: 53.0459% (minimum 75%, Missing); cerebral cortex: 40.1139% (minimum 75%, Missing); choroid plexus: 24.3099% (minimum 75%, Missing); colon: 49.7752% (minimum 70%, Missing); duodenum: 46.9697% (minimum 75%, Missing); esophagus: 52.0484% (minimum 70%, Missing); heart muscle: 28.8533% (minimum 75%, Missing); hippocampal formation: 42.8177% (minimum 75%, Missing); hypothalamus: 41.7790% (minimum 75%, Missing); kidney: 35.4691% (minimum 75%, Missing); liver: 35.3881% (minimum 75%, Missing); lung: 59.9845% (minimum 75%, Missing); lymph node: 54.6159% (minimum 70%, Missing); midbrain: 38.4234% (minimum 75%, Missing); pancreas: 49.5524% (minimum 75%, Missing); parathyroid gland: 44.6172% (minimum 70%, Missing); pituitary gland: 50.1618% (minimum 75%, Missing); rectum: 56.7766% (minimum 70%, Missing); retina: 60.6891% (minimum 75%, Missing); salivary gland: 43.9093% (minimum 70%, Missing); skeletal muscle: 22.0484% (minimum 75%, Missing); skin: 60.4524% (minimum 65%, Missing); small intestine: 48.1068% (minimum 75%, Missing); smooth muscle: 71.8258% (minimum 75%, Missing); spinal cord: 44.8755% (minimum 75%, Missing); spleen: 52.2237% (minimum 65%, Missing); stomach: 46.7713% (minimum 70%, Missing); thymus: 50.4886% (minimum 65%, Missing); thyroid gland: 55.4760% (minimum 65%, Missing); tongue: 25.7561% (minimum 70%, Missing); urinary bladder: 59.2055% (minimum 70%, Missing)",-0.145114,-0.442439,-0.529516,0,6,partial,274,223.4,76,"skeletal muscle: 274 nTPM (vital, limit 1); choroid plexus: 241.3 nTPM (vital, limit 1); tongue: 223.4 nTPM (protected, limit 3); heart muscle: 191.1 nTPM (vital, limit 1); liver: 141.5 nTPM (vital, limit 1); kidney: 141 nTPM (vital, limit 1); amygdala: 124.6 nTPM (vital, limit 1); midbrain: 124.2 nTPM (vital, limit 1); adrenal gland: 124 nTPM (vital, limit 1); basal ganglia: 119.7 nTPM (vital, limit 1); cerebral cortex: 115.7 nTPM (vital, limit 1); hypothalamus: 108 nTPM (vital, limit 1); hippocampal formation: 103.5 nTPM (vital, limit 1); salivary gland: 99 nTPM (protected, limit 3); parathyroid gland: 96.2 nTPM (protected, limit 3); spinal cord: 95.2 nTPM (vital, limit 1); bone marrow: 94.6 nTPM (vital, limit 1); stomach: 88.2 nTPM (protected, limit 3); duodenum: 87.5 nTPM (vital, limit 1); small intestine: 83.6 nTPM (vital, limit 1); pancreas: 78.9 nTPM (vital, limit 1); colon: 78.2 nTPM (protected, limit 3); pituitary gland: 77 nTPM (vital, limit 1); thymus: 76 nTPM (manageable, limit 5); adipose tissue: 73.4 nTPM (manageable, limit 5); esophagus: 71.4 nTPM (protected, limit 3); spleen: 70.9 nTPM (manageable, limit 5); cerebellum: 68.6 nTPM (vital, limit 1); lymph node: 64.4 nTPM (protected, limit 3); thyroid gland: 62.2 nTPM (manageable, limit 5); rectum: 59 nTPM (protected, limit 3); urinary bladder: 53.4 nTPM (protected, limit 3); lung: 51.7 nTPM (vital, limit 1); skin: 50.7 nTPM (manageable, limit 5); retina: 50.2 nTPM (vital, limit 1); smooth muscle: 30.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NDUFA2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000131721,True,compatible,,True,True,True,,0.35,0.3,0.240741,0,1,partial,0.2,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RHOXF2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000131738,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 22.2222% (minimum 55%, Supported); cerebral cortex: 33.3333% (minimum 65%, Supported); hippocampal formation: 50.0000% (minimum 75%, Missing); skin: 0.2488% (minimum 65%, Missing); thymus: 13.3333% (minimum 65%, Missing)",-0.647512,0.0666667,-0.316667,0,6,partial,0.4,0.1,80.2,"skin: 80.2 nTPM (manageable, limit 5)",,67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,hair / cells in cortex/medulla; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KRT33B,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000131747,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 60.5888% (minimum 75%, Missing); esophagus: 69.3478% (minimum 70%, Missing); lymph node: 61.8217% (minimum 70%, Missing); thymus: 33.8821% (minimum 65%, Missing)",-0.311179,-0.0817829,-0.144112,0,6,partial,41.5,39.4,124.5,"thymus: 124.5 nTPM (manageable, limit 5); bone marrow: 41.5 nTPM (vital, limit 1); lymph node: 39.4 nTPM (protected, limit 3); esophagus: 28.2 nTPM (protected, limit 3); rectum: 19.1 nTPM (protected, limit 3); duodenum: 17.6 nTPM (vital, limit 1); colon: 17.2 nTPM (protected, limit 3); small intestine: 16.5 nTPM (vital, limit 1); skin: 14.9 nTPM (manageable, limit 5); spleen: 9.6 nTPM (manageable, limit 5); stomach: 8.6 nTPM (protected, limit 3); smooth muscle: 7.3 nTPM (vital, limit 6); urinary bladder: 5.8 nTPM (protected, limit 3); lung: 3.9 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 2 / cells in basal layer: High (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TOP2A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000131773,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebral cortex: 74.8286% (minimum 75%, Missing)",0.254142,0.136344,-0.00171401,0,11,partial,51.4,29.9,16.2,"cerebral cortex: 51.4 nTPM (vital, limit 1); skeletal muscle: 31.4 nTPM (vital, limit 1); tongue: 29.9 nTPM (protected, limit 3); amygdala: 29.7 nTPM (vital, limit 1); hippocampal formation: 29.1 nTPM (vital, limit 1); spinal cord: 24.4 nTPM (vital, limit 1); retina: 20.3 nTPM (vital, limit 1); kidney: 18.5 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); adipose tissue: 16.2 nTPM (manageable, limit 5); adrenal gland: 15.9 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); cerebellum: 12.6 nTPM (vital, limit 1); colon: 12 nTPM (protected, limit 3); liver: 11.9 nTPM (vital, limit 6); salivary gland: 10.7 nTPM (protected, limit 3); urinary bladder: 10.2 nTPM (protected, limit 3); heart muscle: 10 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); rectum: 8.6 nTPM (protected, limit 3); lung: 8.5 nTPM (vital, limit 6); smooth muscle: 8.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 3); stomach: 6.7 nTPM (protected, limit 3); pituitary gland: 6.6 nTPM (vital, limit 1); skin: 6.2 nTPM (manageable, limit 5); small intestine: 5.7 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); choroid plexus: 4.7 nTPM (vital, limit 1); duodenum: 4 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / fibroblasts: Medium (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / bowman's capsule: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: Medium (Enhanced); rectum / endothelial cells: Low (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / fibroblasts: Medium (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / goblet cells: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: High (Enhanced),76,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KHDRBS3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000131848,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.203147,0.171429,0.0633333,0,1,partial,5.6,3.6,4.2,"choroid plexus: 5.6 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); kidney: 3.5 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 3); parathyroid gland: 3.2 nTPM (protected, limit 3); cerebral cortex: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 3); adrenal gland: 3.1 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZSCAN5A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000131864,True,compatible,,True,True,True,,0.327586,0.279592,0.15,0,7,partial,1.6,0.3,1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,USP29,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,False,gained,selectivity_revised
ENSG00000131914,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.193396,0,2,partial,0.3,0.1,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LIN28A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000131951,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 68.2927% (minimum 75%, Missing)",0.332456,0.282456,-0.0670732,0,80,unavailable,2.6,0.1,0.1,"choroid plexus: 2.6 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRRC9,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,False,False,False,False,unchanged,
ENSG00000132016,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 73.7113% (minimum 75%, Missing)",0.0909326,0.0295918,-0.0128866,0,5,partial,5.1,5.3,5,"esophagus: 5.3 nTPM (protected, limit 3); pancreas: 5.1 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BRME1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000132122,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.19083,0.125127,0.0415309,0,80,unavailable,12.8,10.3,9.2,"retina: 12.8 nTPM (vital, limit 1); parathyroid gland: 10.3 nTPM (protected, limit 3); thyroid gland: 9.2 nTPM (manageable, limit 5); pituitary gland: 8.3 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 3); spinal cord: 6.5 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 3); choroid plexus: 6.1 nTPM (vital, limit 1); adipose tissue: 5.8 nTPM (manageable, limit 5); kidney: 5.8 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 3); lung: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 3); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); rectum: 3.8 nTPM (protected, limit 3); cerebral cortex: 3.8 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); esophagus: 3.3 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000132141,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.327654,0.271451,0.211538,0,6,partial,4.9,3.6,2.8,"skeletal muscle: 4.9 nTPM (vital, limit 1); liver: 4.8 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); tongue: 3.6 nTPM (protected, limit 3); adrenal gland: 3.2 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCT6B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000132436,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.8310% (minimum 75%, Missing); basal ganglia: 69.3878% (minimum 75%, Missing); bone marrow: 54.5455% (minimum 75%, Missing); cerebellum: 61.0778% (minimum 75%, Missing); cerebral cortex: 62.5767% (minimum 75%, Missing); colon: 63.3540% (minimum 70%, Missing); duodenum: 60.7143% (minimum 75%, Missing); esophagus: 54.2553% (minimum 70%, Missing); heart muscle: 73.9130% (minimum 75%, Missing); hippocampal formation: 73.3813% (minimum 75%, Missing); hypothalamus: 73.9130% (minimum 75%, Missing); liver: 69.3878% (minimum 75%, Missing); lymph node: 50.7463% (minimum 70%, Missing); midbrain: 74.4526% (minimum 75%, Missing); rectum: 62.5767% (minimum 70%, Missing); retina: 52.5773% (minimum 75%, Missing); skeletal muscle: 62.5767% (minimum 75%, Missing); skin: 55.1351% (minimum 65%, Missing); small intestine: 62.9630% (minimum 75%, Missing); smooth muscle: 52.0408% (minimum 70%, Approved); spinal cord: 72.8571% (minimum 75%, Missing); spleen: 57.9545% (minimum 65%, Missing); thymus: 51.2563% (minimum 65%, Missing); tongue: 56.9832% (minimum 70%, Missing)",-0.137437,-0.192537,-0.224227,0,1,partial,9.4,9.9,9.7,"lymph node: 9.9 nTPM (protected, limit 3); thymus: 9.7 nTPM (manageable, limit 5); smooth muscle: 9.4 nTPM (vital, limit 2); retina: 9.2 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 3); bone marrow: 8.5 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); tongue: 7.7 nTPM (protected, limit 3); spleen: 7.4 nTPM (manageable, limit 5); duodenum: 6.6 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); cerebral cortex: 6.1 nTPM (vital, limit 1); skeletal muscle: 6.1 nTPM (vital, limit 1); rectum: 6.1 nTPM (protected, limit 3); small intestine: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 3); liver: 4.5 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); hypothalamus: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 3); amygdala: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FIGNL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000132446,True,compatible,,True,True,True,,0.324359,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FTHL17,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000132464,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 53.6765% (minimum 75%, Missing); kidney: 45.9119% (minimum 75%, Missing); pancreas: 67.5926% (minimum 75%, Missing); skeletal muscle: 60.8333% (minimum 75%, Missing)",0.336486,0.102198,-0.290881,0,80,unavailable,8.6,1.8,0.1,"kidney: 8.6 nTPM (vital, limit 1); heart muscle: 6.3 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENAM,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000132554,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308199,0.294992,0.15303,0,80,unavailable,6.4,0.3,2.6,"choroid plexus: 6.4 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RGS22,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000132631,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SCP2D1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000132681,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.290476,0.063285,0.0949198,0,80,unavailable,2.9,4.9,1,"urinary bladder: 4.9 nTPM (protected, limit 3); lymph node: 3.2 nTPM (protected, limit 3); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ATP1A4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000132749,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.312264,0.246197,0.123288,0,80,unavailable,7.4,2.9,2,"bone marrow: 7.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TESMIN,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000132932,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 59.5238% (minimum 75%, Missing); amygdala: 34.7222% (minimum 75%, Missing); basal ganglia: 33.7838% (minimum 75%, Missing); cerebellum: 11.2613% (minimum 75%, Missing); cerebral cortex: 14.6199% (minimum 75%, Missing); hippocampal formation: 33.3333% (minimum 75%, Missing); hypothalamus: 19.6850% (minimum 75%, Missing); midbrain: 31.6456% (minimum 75%, Missing); pituitary gland: 14.4509% (minimum 75%, Missing); retina: 14.8810% (minimum 75%, Missing); spinal cord: 56.8182% (minimum 75%, Missing)",0.311538,0.106452,-0.637387,0,3,partial,19.7,0.6,0.1,"cerebellum: 19.7 nTPM (vital, limit 1); pituitary gland: 14.8 nTPM (vital, limit 1); cerebral cortex: 14.6 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); midbrain: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pituitary gland / cells in anterior : Medium (Enhanced); retina / ganglion cells : Medium (Enhanced); retina / photoreceptor cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; spleen; spleen / cells in red pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ATP8A2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000132950,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 74.9175% (minimum 75%, Missing); bone marrow: 65.2299% (minimum 75%, Missing); lymph node: 69.4190% (minimum 70%, Missing); retina: 72.0635% (minimum 75%, Missing)",0.0484615,-0.0058104,-0.0977011,0,3,partial,12.1,10,9.8,"bone marrow: 12.1 nTPM (vital, limit 1); lymph node: 10 nTPM (protected, limit 3); thymus: 9.8 nTPM (manageable, limit 5); retina: 8.8 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (manageable, limit 5); skin: 7.6 nTPM (manageable, limit 5); adrenal gland: 7.6 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 3); esophagus: 7.4 nTPM (protected, limit 3); spleen: 7.3 nTPM (manageable, limit 5); stomach: 7.1 nTPM (protected, limit 3); urinary bladder: 6.9 nTPM (protected, limit 3); liver: 6.7 nTPM (vital, limit 1); adipose tissue: 6.7 nTPM (manageable, limit 5); smooth muscle: 6.6 nTPM (vital, limit 1); lung: 6.5 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); duodenum: 6 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 3); salivary gland: 5.6 nTPM (protected, limit 3); parathyroid gland: 5.3 nTPM (protected, limit 3); pancreas: 5.3 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZMYM5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000132953,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.8235% (minimum 65%, Missing); adrenal gland: 63.1579% (minimum 75%, Missing); bone marrow: 37.2671% (minimum 75%, Missing); cerebellum: 56.0748% (minimum 75%, Missing); cerebral cortex: 60.0000% (minimum 75%, Missing); choroid plexus: 68.1818% (minimum 75%, Missing); colon: 57.1429% (minimum 70%, Missing); duodenum: 62.5000% (minimum 75%, Missing); esophagus: 56.0748% (minimum 70%, Missing); heart muscle: 36.5854% (minimum 75%, Missing); kidney: 55.0459% (minimum 75%, Missing); liver: 60.0000% (minimum 75%, Missing); lung: 50.4202% (minimum 75%, Missing); lymph node: 45.4545% (minimum 70%, Missing); pancreas: 59.4059% (minimum 75%, Missing); parathyroid gland: 48.7805% (minimum 70%, Missing); pituitary gland: 67.4157% (minimum 75%, Missing); rectum: 52.1739% (minimum 70%, Missing); retina: 31.2500% (minimum 75%, Missing); salivary gland: 62.5000% (minimum 70%, Missing); skeletal muscle: 12.2951% (minimum 75%, Missing); skin: 52.1739% (minimum 65%, Missing); small intestine: 61.8557% (minimum 75%, Missing); smooth muscle: 52.6316% (minimum 75%, Missing); spinal cord: 68.9655% (minimum 75%, Missing); spleen: 51.2821% (minimum 65%, Missing); stomach: 56.6038% (minimum 70%, Missing); thymus: 46.5116% (minimum 65%, Missing); thyroid gland: 48.7805% (minimum 65%, Missing); tongue: 27.0270% (minimum 70%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",-0.184884,-0.42973,-0.627049,0,80,unavailable,42.8,16.2,6.9,"skeletal muscle: 42.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 3); retina: 13.2 nTPM (vital, limit 1); heart muscle: 10.4 nTPM (vital, limit 1); bone marrow: 10.1 nTPM (vital, limit 1); lymph node: 7.2 nTPM (protected, limit 3); thymus: 6.9 nTPM (manageable, limit 5); thyroid gland: 6.3 nTPM (manageable, limit 5); parathyroid gland: 6.3 nTPM (protected, limit 3); lung: 5.9 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 3); smooth muscle: 5.4 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); cerebellum: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); colon: 4.5 nTPM (protected, limit 3); urinary bladder: 4.5 nTPM (protected, limit 3); pancreas: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); adrenal gland: 3.5 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,XPO4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000132958,True,compatible,,True,True,True,,0.322603,0.259459,0.184211,0,80,unavailable,0.5,0.3,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TPTE2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000132972,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.295781,0.237448,0,2,partial,0.3,0.1,0,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RNF17,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000133019,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 71.6667% (minimum 75%, Missing); basal ganglia: 74.1379% (minimum 75%, Missing); cerebral cortex: 30.7143% (minimum 75%, Missing); colon: 39.0909% (minimum 70%, Missing); esophagus: 37.3913% (minimum 70%, Missing); hippocampal formation: 67.1875% (minimum 75%, Missing); pancreas: 29.4521% (minimum 75%, Missing); rectum: 60.5634% (minimum 70%, Missing); retina: 72.8814% (minimum 75%, Missing); salivary gland: 20.1878% (minimum 70%, Missing); smooth muscle: 51.8072% (minimum 75%, Missing); stomach: 46.7391% (minimum 70%, Missing); urinary bladder: 38.7387% (minimum 70%, Missing)",0.0435484,-0.498122,-0.455479,0,2,partial,10.3,17,1.9,"salivary gland: 17 nTPM (protected, limit 3); pancreas: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.7 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 3); urinary bladder: 6.8 nTPM (protected, limit 3); colon: 6.7 nTPM (protected, limit 3); stomach: 4.9 nTPM (protected, limit 3); smooth muscle: 4 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CHRM3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000133101,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344962,0.23607,0.119087,0,4,partial,11.9,21.5,0.6,"parathyroid gland: 21.5 nTPM (protected, limit 12); basal ganglia: 11.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); choroid plexus: 8.2 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 6); pituitary gland: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 6); hippocampal formation: 7.4 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCNA1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000133111,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.1111% (minimum 65%, Missing); adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 61.1111% (minimum 75%, Missing); basal ganglia: 61.6822% (minimum 75%, Missing); bone marrow: 52.8000% (minimum 75%, Missing); cerebellum: 48.5294% (minimum 75%, Missing); cerebral cortex: 50.3817% (minimum 75%, Missing); colon: 57.3913% (minimum 70%, Missing); duodenum: 68.7500% (minimum 75%, Missing); esophagus: 69.4737% (minimum 70%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); hippocampal formation: 61.6822% (minimum 75%, Missing); hypothalamus: 62.2642% (minimum 75%, Missing); kidney: 67.3469% (minimum 75%, Missing); liver: 72.5275% (minimum 75%, Missing); lung: 61.6822% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); midbrain: 61.6822% (minimum 75%, Missing); pancreas: 59.4595% (minimum 75%, Missing); parathyroid gland: 52.3810% (minimum 70%, Missing); pituitary gland: 59.4595% (minimum 75%, Missing); rectum: 62.2642% (minimum 70%, Missing); retina: 55.4622% (minimum 75%, Missing); salivary gland: 58.4071% (minimum 70%, Missing); skeletal muscle: 61.6822% (minimum 75%, Missing); small intestine: 60.5505% (minimum 75%, Missing); smooth muscle: 54.5455% (minimum 75%, Missing); spinal cord: 57.3913% (minimum 75%, Missing); spleen: 57.3913% (minimum 65%, Missing); stomach: 61.6822% (minimum 70%, Missing); thymus: 45.2055% (minimum 65%, Missing); thyroid gland: 53.6585% (minimum 65%, Missing); tongue: 69.4737% (minimum 70%, Missing); urinary bladder: 62.8571% (minimum 70%, Missing)",-0.197945,-0.2,-0.264706,0,80,unavailable,7,6.6,8,"thymus: 8 nTPM (manageable, limit 5); cerebellum: 7 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 3); cerebral cortex: 6.5 nTPM (vital, limit 1); parathyroid gland: 6 nTPM (protected, limit 3); bone marrow: 5.9 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); smooth muscle: 5.5 nTPM (vital, limit 1); retina: 5.3 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); colon: 4.9 nTPM (protected, limit 3); salivary gland: 4.7 nTPM (protected, limit 3); pancreas: 4.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 3); lung: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 3); urinary bladder: 3.9 nTPM (protected, limit 3); heart muscle: 3.3 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RFXAP,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000133477,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.185665,0.11835,0.0928875,0,2,partial,13.1,19.7,18.2,"esophagus: 19.7 nTPM (protected, limit 12); pancreas: 13.1 nTPM (vital, limit 6); small intestine: 7.4 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 3); colon: 5.2 nTPM (protected, limit 3); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM83F,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000133640,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 52.4476% (minimum 75%, Missing); retina: 63.8298% (minimum 75%, Missing)",0.217052,0.137989,-0.225524,0,80,unavailable,13.6,2.9,2.3,"choroid plexus: 13.6 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRRIQ1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000133816,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 72.6678% (minimum 75%, Missing); cerebellum: 18.2042% (minimum 75%, Missing); cerebral cortex: 44.9848% (minimum 75%, Missing); colon: 60.8219% (minimum 70%, Missing); esophagus: 65.5835% (minimum 70%, Missing); heart muscle: 48.1040% (minimum 70%, Approved); hippocampal formation: 61.6667% (minimum 75%, Missing); lung: 64.2547% (minimum 75%, Missing); rectum: 62.9787% (minimum 70%, Missing); skeletal muscle: 66.5667% (minimum 75%, Missing); small intestine: 71.0400% (minimum 75%, Missing); smooth muscle: 49.3882% (minimum 75%, Missing)",0.0962185,-0.0917808,-0.567958,0,2,partial,199.5,28.6,15.1,"cerebellum: 199.5 nTPM (vital, limit 1); cerebral cortex: 54.3 nTPM (vital, limit 1); heart muscle: 47.9 nTPM (vital, limit 2); smooth muscle: 45.5 nTPM (vital, limit 1); colon: 28.6 nTPM (protected, limit 3); hippocampal formation: 27.6 nTPM (vital, limit 1); rectum: 26.1 nTPM (protected, limit 3); lung: 24.7 nTPM (vital, limit 1); esophagus: 23.3 nTPM (protected, limit 3); skeletal muscle: 22.3 nTPM (vital, limit 1); small intestine: 18.1 nTPM (vital, limit 1); urinary bladder: 17.8 nTPM (protected, limit 3); amygdala: 16.7 nTPM (vital, limit 1); skin: 15.1 nTPM (manageable, limit 5); bone marrow: 14.7 nTPM (vital, limit 1); choroid plexus: 13.8 nTPM (vital, limit 1); duodenum: 13.4 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 3); thyroid gland: 8.7 nTPM (manageable, limit 5); spinal cord: 8.4 nTPM (vital, limit 1); basal ganglia: 8.2 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); pancreas: 6.8 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); tongue: 4.9 nTPM (protected, limit 3); lymph node: 4.5 nTPM (protected, limit 3); retina: 4.1 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MICAL2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000133863,True,compatible,,True,True,True,,0.35,0.3,0.0982249,0,3,partial,5.1,0.4,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX15,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,False,gained,selectivity_revised
ENSG00000133962,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 62.5000% (minimum 70%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 71.4286% (minimum 75%, Missing); lung: 62.5000% (minimum 75%, Missing); lymph node: 52.6316% (minimum 70%, Missing); pancreas: 8.7719% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 58.8235% (minimum 75%, Missing); salivary gland: 29.4118% (minimum 70%, Missing); skeletal muscle: 47.6190% (minimum 75%, Missing); skin: 31.2500% (minimum 65%, Missing); small intestine: 52.6316% (minimum 75%, Missing); spleen: 62.5000% (minimum 65%, Missing); stomach: 41.6667% (minimum 70%, Missing)",-0.3375,-0.405882,-0.662281,0,80,unavailable,10.4,2.4,2.2,"pancreas: 10.4 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CATSPERB,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000133980,True,compatible,,True,True,True,,0.291176,0.1,0.138889,0,80,unavailable,0.2,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,VRTN,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000134007,True,compatible,,True,True,True,,0.35,0.3,0.177273,0,1,partial,0.4,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ADAM20,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000134046,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.1593% (minimum 65%, Missing); bone marrow: 60.3550% (minimum 75%, Missing); colon: 64.6934% (minimum 70%, Missing); duodenum: 72.3404% (minimum 75%, Missing); esophagus: 51.6020% (minimum 70%, Missing); heart muscle: 68.0000% (minimum 75%, Missing); kidney: 65.3846% (minimum 75%, Missing); liver: 65.1064% (minimum 75%, Missing); lung: 65.8065% (minimum 75%, Missing); lymph node: 49.4346% (minimum 70%, Missing); pancreas: 64.4211% (minimum 75%, Missing); parathyroid gland: 65.8065% (minimum 70%, Missing); rectum: 65.8065% (minimum 70%, Missing); retina: 68.9189% (minimum 75%, Missing); salivary gland: 61.9433% (minimum 70%, Missing); skeletal muscle: 67.2527% (minimum 75%, Missing); skin: 55.2347% (minimum 65%, Missing); small intestine: 66.9584% (minimum 75%, Missing); smooth muscle: 72.6841% (minimum 75%, Missing); spleen: 59.7656% (minimum 65%, Missing); stomach: 69.2308% (minimum 70%, Missing); thymus: 61.0778% (minimum 65%, Missing); thyroid gland: 50.4119% (minimum 65%, Missing); tongue: 65.5246% (minimum 70%, Missing); urinary bladder: 60.2362% (minimum 70%, Missing)",-0.145881,-0.205654,-0.14645,0,4,partial,20.1,31.3,30.1,"lymph node: 31.3 nTPM (protected, limit 3); thyroid gland: 30.1 nTPM (manageable, limit 5); esophagus: 28.7 nTPM (protected, limit 3); adipose tissue: 25.9 nTPM (manageable, limit 5); skin: 24.8 nTPM (manageable, limit 5); spleen: 20.6 nTPM (manageable, limit 5); urinary bladder: 20.2 nTPM (protected, limit 3); bone marrow: 20.1 nTPM (vital, limit 1); thymus: 19.5 nTPM (manageable, limit 5); salivary gland: 18.8 nTPM (protected, limit 3); pancreas: 16.9 nTPM (vital, limit 1); colon: 16.7 nTPM (protected, limit 3); liver: 16.4 nTPM (vital, limit 1); kidney: 16.2 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 3); parathyroid gland: 15.9 nTPM (protected, limit 3); rectum: 15.9 nTPM (protected, limit 3); lung: 15.9 nTPM (vital, limit 1); small intestine: 15.1 nTPM (vital, limit 1); skeletal muscle: 14.9 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 3); duodenum: 11.7 nTPM (vital, limit 1); smooth muscle: 11.5 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); cerebellum: 10.1 nTPM (vital, limit 1); midbrain: 9.5 nTPM (vital, limit 1); basal ganglia: 9.5 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MBD2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000134049,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.9294% (minimum 65%, Missing); adrenal gland: 45.0658% (minimum 75%, Missing); amygdala: 64.0187% (minimum 75%, Missing); basal ganglia: 64.3192% (minimum 75%, Missing); bone marrow: 48.9286% (minimum 75%, Missing); cerebellum: 48.9286% (minimum 75%, Missing); cerebral cortex: 62.2727% (minimum 75%, Missing); choroid plexus: 47.5694% (minimum 75%, Missing); colon: 50.1832% (minimum 70%, Missing); duodenum: 45.3642% (minimum 75%, Missing); esophagus: 53.9370% (minimum 70%, Missing); heart muscle: 45.6667% (minimum 75%, Missing); hippocampal formation: 64.6226% (minimum 75%, Missing); hypothalamus: 59.0517% (minimum 75%, Missing); kidney: 31.1364% (minimum 75%, Missing); liver: 42.0245% (minimum 75%, Missing); lung: 53.5156% (minimum 75%, Missing); lymph node: 55.2419% (minimum 70%, Missing); midbrain: 64.0187% (minimum 75%, Missing); pancreas: 50.9294% (minimum 75%, Missing); parathyroid gland: 42.5466% (minimum 70%, Missing); pituitary gland: 47.5694% (minimum 75%, Missing); rectum: 52.0913% (minimum 70%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 48.4099% (minimum 70%, Missing); skeletal muscle: 31.3501% (minimum 75%, Missing); skin: 50.5535% (minimum 65%, Missing); small intestine: 47.2414% (minimum 75%, Missing); smooth muscle: 59.8253% (minimum 65%, Supported); spinal cord: 64.9289% (minimum 75%, Missing); spleen: 55.9184% (minimum 65%, Missing); stomach: 46.9178% (minimum 70%, Missing); thymus: 55.9184% (minimum 65%, Missing); thyroid gland: 47.0790% (minimum 65%, Missing); tongue: 39.5954% (minimum 70%, Missing); urinary bladder: 50.5535% (minimum 70%, Missing)",-0.17921,-0.304046,-0.438636,0,13,partial,30.3,20.9,15.4,"kidney: 30.3 nTPM (vital, limit 1); skeletal muscle: 30 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 3); liver: 18.9 nTPM (vital, limit 1); parathyroid gland: 18.5 nTPM (protected, limit 3); adrenal gland: 16.7 nTPM (vital, limit 1); duodenum: 16.5 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 3); thyroid gland: 15.4 nTPM (manageable, limit 5); small intestine: 15.3 nTPM (vital, limit 1); pituitary gland: 15.1 nTPM (vital, limit 1); choroid plexus: 15.1 nTPM (vital, limit 1); salivary gland: 14.6 nTPM (protected, limit 3); cerebellum: 14.3 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 3); skin: 13.4 nTPM (manageable, limit 5); urinary bladder: 13.4 nTPM (protected, limit 3); adipose tissue: 13.2 nTPM (manageable, limit 5); pancreas: 13.2 nTPM (vital, limit 1); rectum: 12.6 nTPM (protected, limit 3); lung: 11.9 nTPM (vital, limit 1); esophagus: 11.7 nTPM (protected, limit 3); lymph node: 11.1 nTPM (protected, limit 3); spleen: 10.8 nTPM (manageable, limit 5); thymus: 10.8 nTPM (manageable, limit 5); hypothalamus: 9.5 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 3); cerebral cortex: 8.3 nTPM (vital, limit 1); amygdala: 7.7 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / goblet cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / GLUC cells - cytoplasm/membrane: Medium (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - dendrites: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebellum / white matter cells - cytoplasm/membrane: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in granular layer: Medium (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / endothelial cells: Medium (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Medium (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),97,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IER3IP1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000134146,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.3158% (minimum 65%, Missing); adrenal gland: 59.7765% (minimum 75%, Missing); amygdala: 72.2973% (minimum 75%, Missing); basal ganglia: 71.3333% (minimum 75%, Missing); bone marrow: 66.4596% (minimum 70%, Approved); cerebral cortex: 66.8750% (minimum 75%, Missing); choroid plexus: 68.5897% (minimum 75%, Missing); colon: 62.2093% (minimum 70%, Missing); duodenum: 63.6905% (minimum 75%, Missing); esophagus: 53.7688% (minimum 65%, Approved); heart muscle: 52.1951% (minimum 75%, Missing); hippocampal formation: 73.7931% (minimum 75%, Missing); hypothalamus: 73.2877% (minimum 75%, Missing); kidney: 51.4423% (minimum 75%, Missing); liver: 57.8378% (minimum 75%, Missing); lung: 67.2956% (minimum 75%, Missing); midbrain: 68.5897% (minimum 75%, Missing); pancreas: 43.6735% (minimum 75%, Missing); parathyroid gland: 56.0209% (minimum 70%, Missing); pituitary gland: 65.2439% (minimum 75%, Missing); rectum: 61.1429% (minimum 70%, Missing); retina: 55.4404% (minimum 75%, Missing); salivary gland: 62.2093% (minimum 70%, Missing); skeletal muscle: 50.7109% (minimum 75%, Missing); skin: 53.2338% (minimum 60%, Approved); small intestine: 62.5731% (minimum 75%, Missing); smooth muscle: 63.3136% (minimum 70%, Approved); spinal cord: 63.6905% (minimum 75%, Missing); stomach: 62.2093% (minimum 70%, Missing); thymus: 61.1429% (minimum 65%, Missing); thyroid gland: 50.4717% (minimum 65%, Missing); tongue: 61.8497% (minimum 70%, Missing); urinary bladder: 57.8378% (minimum 70%, Missing)",-0.145283,-0.139791,-0.313265,0,2,partial,13.8,9.2,10.5,"pancreas: 13.8 nTPM (vital, limit 1); thyroid gland: 10.5 nTPM (manageable, limit 5); skeletal muscle: 10.4 nTPM (vital, limit 1); kidney: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); esophagus: 9.2 nTPM (protected, limit 4); retina: 8.6 nTPM (vital, limit 1); parathyroid gland: 8.4 nTPM (protected, limit 3); adipose tissue: 8.3 nTPM (manageable, limit 5); liver: 7.8 nTPM (vital, limit 1); urinary bladder: 7.8 nTPM (protected, limit 3); adrenal gland: 7.2 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 3); thymus: 6.8 nTPM (manageable, limit 5); tongue: 6.6 nTPM (protected, limit 3); salivary gland: 6.5 nTPM (protected, limit 3); colon: 6.5 nTPM (protected, limit 3); stomach: 6.5 nTPM (protected, limit 3); small intestine: 6.4 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 2); spinal cord: 6.1 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 2); cerebral cortex: 5.3 nTPM (vital, limit 1); lung: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 4); midbrain: 4.9 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); cerebellum: 3.5 nTPM (vital, limit 2)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DPH6,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000134160,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 10.9948% (minimum 75%, Missing); skin: 30.8824% (minimum 50%, Enhanced); spinal cord: 72.4138% (minimum 75%, Missing)",-0.191176,0.3,-0.640052,0,2,partial,17,0.1,4.7,"retina: 17 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / outer plexiform layer: Medium (Enhanced),62,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRPM1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000134215,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 63.4799% (minimum 75%, Missing); colon: 45.4172% (minimum 70%, Missing); esophagus: 49.5522% (minimum 70%, Uncertain); kidney: 29.0718% (minimum 75%, Missing); pancreas: 66.4000% (minimum 75%, Missing); rectum: 40.2913% (minimum 70%, Missing); skin: 41.0383% (minimum 65%, Missing); small intestine: 69.1667% (minimum 75%, Missing)",-0.239617,-0.297087,-0.459282,0,7,partial,81,49.2,47.7,"kidney: 81 nTPM (vital, limit 1); rectum: 49.2 nTPM (protected, limit 3); skin: 47.7 nTPM (manageable, limit 5); colon: 39.9 nTPM (protected, limit 3); esophagus: 33.8 nTPM (protected, limit 3); bone marrow: 19.1 nTPM (vital, limit 1); pancreas: 16.8 nTPM (vital, limit 1); small intestine: 14.8 nTPM (vital, limit 1); urinary bladder: 12.3 nTPM (protected, limit 3); spleen: 10.9 nTPM (manageable, limit 5); lymph node: 10.1 nTPM (protected, limit 3); thyroid gland: 9.6 nTPM (manageable, limit 5); duodenum: 9 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); retina: 7.1 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 3); salivary gland: 7.1 nTPM (protected, limit 3); choroid plexus: 6.7 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,VAV3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000134249,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ADAM30,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000134256,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 46.1538% (minimum 75%, Missing); amygdala: 75.0000% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); bone marrow: 11.3208% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); colon: 25.0000% (minimum 70%, Missing); duodenum: 14.6341% (minimum 75%, Missing); esophagus: 40.0000% (minimum 70%, Missing); heart muscle: 60.0000% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); liver: 50.0000% (minimum 75%, Missing); lung: 8.4507% (minimum 75%, Missing); lymph node: 24.0000% (minimum 70%, Missing); pancreas: 42.8571% (minimum 75%, Missing); rectum: 20.6897% (minimum 70%, Missing); salivary gland: 28.5714% (minimum 70%, Missing); skin: 40.0000% (minimum 65%, Missing); small intestine: 8.9552% (minimum 75%, Missing); smooth muscle: 31.5789% (minimum 75%, Missing); spinal cord: 75.0000% (minimum 75%, Missing); spleen: 16.2162% (minimum 60%, Approved); stomach: 30.0000% (minimum 70%, Missing); thymus: 33.3333% (minimum 65%, Missing); urinary bladder: 33.3333% (minimum 65%, Approved)",-0.437838,-0.493103,-0.665493,0,2,partial,6.5,2.3,3.1,"lung: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); bone marrow: 4.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CD101,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000134376,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 19.4444% (minimum 75%, Missing); basal ganglia: 19.1781% (minimum 75%, Missing); cerebellum: 22.7642% (minimum 70%, Approved); cerebral cortex: 19.1781% (minimum 70%, Approved); hippocampal formation: 22.4000% (minimum 75%, Missing); hypothalamus: 30.1075% (minimum 75%, Missing); midbrain: 38.8889% (minimum 75%, Missing); pituitary gland: 57.1429% (minimum 75%, Missing); retina: 3.7234% (minimum 75%, Missing); spinal cord: 43.7500% (minimum 75%, Missing)",0.333333,0.175,-0.712766,0,0,routine_complete,72.4,0.4,0.2,"retina: 72.4 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 2); amygdala: 11.6 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 2); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",retina / outer plexiform layer: Low (Approved); retina / photoreceptor cells: Medium (Approved),63,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CRB1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000134389,False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,1,partial,162,0,0,"liver: 162 nTPM (vital, limit 3)",,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFHR5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000134490,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.3810% (minimum 65%, Missing); basal ganglia: 68.7500% (minimum 75%, Missing); bone marrow: 66.6667% (minimum 75%, Missing); cerebral cortex: 45.8333% (minimum 75%, Missing); colon: 57.8947% (minimum 70%, Missing); duodenum: 59.4595% (minimum 75%, Missing); esophagus: 57.8947% (minimum 70%, Missing); heart muscle: 59.4595% (minimum 75%, Missing); kidney: 68.7500% (minimum 75%, Missing); liver: 57.8947% (minimum 75%, Missing); lung: 61.1111% (minimum 75%, Missing); lymph node: 61.1111% (minimum 70%, Missing); pancreas: 64.7059% (minimum 75%, Missing); parathyroid gland: 48.8889% (minimum 70%, Missing); pituitary gland: 68.7500% (minimum 75%, Missing); rectum: 50.0000% (minimum 70%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 68.7500% (minimum 75%, Missing); small intestine: 66.6667% (minimum 75%, Missing); smooth muscle: 44.0000% (minimum 75%, Missing); spleen: 61.1111% (minimum 65%, Missing); stomach: 61.1111% (minimum 70%, Missing); thyroid gland: 51.1628% (minimum 65%, Missing); urinary bladder: 59.4595% (minimum 70%, Missing)",-0.138372,-0.211111,-0.31,0,80,unavailable,2.8,2.3,2.1,"smooth muscle: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TMEM241,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000134588,True,compatible,,True,True,True,,0.2,0.3,0.25,0,3,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,USP26,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000134595,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"hypothalamus: 74.1667% (minimum 75%, Missing)",0.338889,0.3,-0.00833333,0,80,unavailable,3.1,0,0.1,"hypothalamus: 3.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SOX3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000134640,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.3,0.0192308,0,3,partial,0.3,0,0,,caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); hippocampus / glial cells: High (Supported); retina / nerve fiber layer: High (Supported); skin 1 / fibroblasts: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); thyroid gland / glandular cells: Medium (Supported),60,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibroblasts; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MTNR1B,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016",False,False,False,False,False,unchanged,
ENSG00000134690,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 39.8182% (minimum 75%, Missing); duodenum: 73.0000% (minimum 75%, Missing); lymph node: 53.5452% (minimum 70%, Missing); rectum: 66.7683% (minimum 70%, Missing); thymus: 36.6834% (minimum 65%, Missing)",-0.283166,-0.164548,-0.351818,0,12,partial,33.1,19,37.8,"thymus: 37.8 nTPM (manageable, limit 5); bone marrow: 33.1 nTPM (vital, limit 1); lymph node: 19 nTPM (protected, limit 3); rectum: 10.9 nTPM (protected, limit 3); colon: 9.1 nTPM (protected, limit 3); esophagus: 9 nTPM (protected, limit 3); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 7.1 nTPM (vital, limit 1); skin: 6.2 nTPM (manageable, limit 5); stomach: 4.7 nTPM (protected, limit 3); retina: 1.8 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Low (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: Medium (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Microvilli: Low (Enhanced); rectum / goblet cells: Low (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),90,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CDCA8,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000134758,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 55.0285% (minimum 75%, Missing)",0.154997,0.130946,-0.199715,0,80,unavailable,94.8,23.6,28.1,"bone marrow: 94.8 nTPM (vital, limit 1); thymus: 28.1 nTPM (manageable, limit 5); lymph node: 23.6 nTPM (protected, limit 3); colon: 22.7 nTPM (protected, limit 3); liver: 21 nTPM (vital, limit 1); spleen: 21 nTPM (manageable, limit 5); rectum: 19.6 nTPM (protected, limit 3); small intestine: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); pancreas: 15.8 nTPM (vital, limit 1); esophagus: 14.4 nTPM (protected, limit 3); stomach: 13.8 nTPM (protected, limit 3); adipose tissue: 13.2 nTPM (manageable, limit 5); lung: 12.9 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 3); thyroid gland: 11.5 nTPM (manageable, limit 5); smooth muscle: 11.3 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 3); spinal cord: 10.5 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 3); kidney: 9.3 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); skin: 8.6 nTPM (manageable, limit 5); cerebellum: 8.4 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); amygdala: 6.9 nTPM (vital, limit 1); skeletal muscle: 6.7 nTPM (vital, limit 1); tongue: 6.6 nTPM (protected, limit 3); basal ganglia: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RNF138,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000134940,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.229275,0,3,partial,2.4,0.4,0.1,"basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ACRV1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000134970,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 63.1919% (minimum 75%, Missing); bone marrow: 68.5686% (minimum 75%, Missing); cerebral cortex: 68.4316% (minimum 75%, Missing); colon: 62.7289% (minimum 70%, Missing); duodenum: 65.6130% (minimum 75%, Missing); esophagus: 68.5686% (minimum 70%, Missing); heart muscle: 61.9910% (minimum 75%, Missing); kidney: 56.7053% (minimum 75%, Missing); liver: 46.7896% (minimum 75%, Missing); lung: 69.8267% (minimum 75%, Missing); pancreas: 66.6991% (minimum 75%, Missing); parathyroid gland: 56.9410% (minimum 70%, Missing); pituitary gland: 71.5778% (minimum 75%, Missing); rectum: 62.6143% (minimum 70%, Missing); salivary gland: 61.8790% (minimum 70%, Missing); small intestine: 64.7448% (minimum 75%, Missing); smooth muscle: 61.2154% (minimum 65%, Supported); spinal cord: 66.3760% (minimum 75%, Missing); stomach: 62.9017% (minimum 70%, Missing); thyroid gland: 46.9500% (minimum 65%, Missing); urinary bladder: 65.3626% (minimum 70%, Missing)",-0.1805,-0.13059,-0.282104,0,4,partial,77.9,51.8,77.4,"liver: 77.9 nTPM (vital, limit 1); thyroid gland: 77.4 nTPM (manageable, limit 5); kidney: 52.3 nTPM (vital, limit 1); parathyroid gland: 51.8 nTPM (protected, limit 3); smooth muscle: 43.4 nTPM (vital, limit 3); salivary gland: 42.2 nTPM (protected, limit 3); heart muscle: 42 nTPM (vital, limit 1); rectum: 40.9 nTPM (protected, limit 3); colon: 40.7 nTPM (protected, limit 3); stomach: 40.4 nTPM (protected, limit 3); adrenal gland: 39.9 nTPM (vital, limit 1); small intestine: 37.3 nTPM (vital, limit 1); urinary bladder: 36.3 nTPM (protected, limit 3); duodenum: 35.9 nTPM (vital, limit 1); spinal cord: 34.7 nTPM (vital, limit 1); pancreas: 34.2 nTPM (vital, limit 1); adipose tissue: 33.8 nTPM (manageable, limit 5); cerebral cortex: 31.6 nTPM (vital, limit 1); esophagus: 31.4 nTPM (protected, limit 3); bone marrow: 31.4 nTPM (vital, limit 1); lung: 29.6 nTPM (vital, limit 1); pituitary gland: 27.2 nTPM (vital, limit 1); spleen: 25.3 nTPM (manageable, limit 5); tongue: 23.8 nTPM (protected, limit 3); lymph node: 22.9 nTPM (protected, limit 3); midbrain: 22.4 nTPM (vital, limit 1); hippocampal formation: 22 nTPM (vital, limit 1); skeletal muscle: 21.2 nTPM (vital, limit 1); basal ganglia: 21 nTPM (vital, limit 1); hypothalamus: 20.8 nTPM (vital, limit 1); amygdala: 19.9 nTPM (vital, limit 1); thymus: 19 nTPM (manageable, limit 5); retina: 18.6 nTPM (vital, limit 1); skin: 18.4 nTPM (manageable, limit 5); choroid plexus: 11.7 nTPM (vital, limit 1); cerebellum: 10.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Low (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Medium (Supported); skin 1 / langerhans cells: Low (Supported); skin 1 / lymphocytes: Medium (Supported); skin 1 / vascular mural cells: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / lymphocytes: Medium (Supported); small intestine / glandular cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Low (Supported); urinary bladder / urothelial cells: Medium (Supported),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TMED7,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000135119,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 35.6436% (minimum 75%, Missing); basal ganglia: 31.0345% (minimum 75%, Missing); cerebellum: 27.4809% (minimum 75%, Missing); cerebral cortex: 24.8276% (minimum 75%, Missing); choroid plexus: 42.3529% (minimum 75%, Missing); hippocampal formation: 31.5789% (minimum 75%, Missing); hypothalamus: 29.7521% (minimum 75%, Missing); midbrain: 34.9515% (minimum 75%, Missing); pituitary gland: 41.8605% (minimum 75%, Missing); retina: 42.8571% (minimum 75%, Missing); spinal cord: 42.3529% (minimum 75%, Missing)",0.0846939,0.0826087,-0.501724,0,0,routine_complete,10.9,1,1.3,"cerebral cortex: 10.9 nTPM (vital, limit 1); cerebellum: 9.5 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RNFT2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000135175,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OCM2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000135222,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340454,0.3,0.25,0,0,routine_complete,0.1,3.1,5.4,"thymus: 5.4 nTPM (manageable, limit 5)",,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CSN2,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000135248,True,compatible,,True,True,True,,0.348906,0.298906,0.239166,0,80,unavailable,1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GARIN1B,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000135314,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 42.4084% (minimum 75%, Missing); basal ganglia: 36.3229% (minimum 75%, Missing); cerebellum: 46.8208% (minimum 75%, Missing); cerebral cortex: 37.1560% (minimum 75%, Missing); choroid plexus: 66.9421% (minimum 75%, Missing); heart muscle: 68.6441% (minimum 75%, Missing); hippocampal formation: 46.8208% (minimum 75%, Missing); hypothalamus: 46.2857% (minimum 75%, Missing); midbrain: 45.0000% (minimum 75%, Missing); pituitary gland: 52.5974% (minimum 75%, Missing); retina: 69.2308% (minimum 75%, Missing); spinal cord: 53.2895% (minimum 75%, Missing)",0.128846,0.0941176,-0.386771,0,80,unavailable,14.2,2.1,2.3,"basal ganglia: 14.2 nTPM (vital, limit 1); cerebral cortex: 13.7 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 9.2 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KHDC1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000135334,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 44.1125% (minimum 65%, Missing); adrenal gland: 41.1475% (minimum 75%, Missing); amygdala: 42.5424% (minimum 75%, Missing); basal ganglia: 43.1271% (minimum 75%, Missing); bone marrow: 26.5048% (minimum 75%, Missing); cerebellum: 47.8095% (minimum 75%, Missing); cerebral cortex: 41.2151% (minimum 75%, Missing); choroid plexus: 50.7071% (minimum 75%, Missing); colon: 56.6591% (minimum 70%, Missing); duodenum: 66.9333% (minimum 75%, Missing); esophagus: 43.7282% (minimum 70%, Missing); heart muscle: 45.6364% (minimum 75%, Missing); hippocampal formation: 43.6522% (minimum 75%, Missing); hypothalamus: 44.7415% (minimum 75%, Missing); kidney: 55.4084% (minimum 75%, Missing); liver: 45.3069% (minimum 75%, Missing); lung: 43.8045% (minimum 75%, Missing); lymph node: 47.5379% (minimum 70%, Missing); midbrain: 46.0550% (minimum 75%, Missing); pancreas: 66.2269% (minimum 75%, Missing); parathyroid gland: 59.3381% (minimum 70%, Missing); pituitary gland: 52.4008% (minimum 75%, Missing); rectum: 67.4731% (minimum 70%, Missing); retina: 46.5677% (minimum 75%, Missing); salivary gland: 51.3292% (minimum 70%, Missing); skeletal muscle: 21.0747% (minimum 75%, Missing); skin: 53.0655% (minimum 65%, Missing); small intestine: 52.9536% (minimum 75%, Missing); smooth muscle: 61.3692% (minimum 75%, Missing); spinal cord: 44.5826% (minimum 75%, Missing); spleen: 34.3836% (minimum 65%, Missing); stomach: 60.6280% (minimum 70%, Missing); thymus: 45.2252% (minimum 65%, Missing); thyroid gland: 60.0478% (minimum 65%, Missing); tongue: 38.0303% (minimum 70%, Missing); urinary bladder: 52.7311% (minimum 70%, Missing)",-0.306164,-0.319697,-0.539253,0,80,unavailable,94,40.9,47.9,"skeletal muscle: 94 nTPM (vital, limit 1); bone marrow: 69.6 nTPM (vital, limit 1); spleen: 47.9 nTPM (manageable, limit 5); tongue: 40.9 nTPM (protected, limit 3); adrenal gland: 35.9 nTPM (vital, limit 1); cerebral cortex: 35.8 nTPM (vital, limit 1); amygdala: 33.9 nTPM (vital, limit 1); basal ganglia: 33.1 nTPM (vital, limit 1); hippocampal formation: 32.4 nTPM (vital, limit 1); esophagus: 32.3 nTPM (protected, limit 3); lung: 32.2 nTPM (vital, limit 1); adipose tissue: 31.8 nTPM (manageable, limit 5); spinal cord: 31.2 nTPM (vital, limit 1); hypothalamus: 31 nTPM (vital, limit 1); thymus: 30.4 nTPM (manageable, limit 5); liver: 30.3 nTPM (vital, limit 1); heart muscle: 29.9 nTPM (vital, limit 1); midbrain: 29.4 nTPM (vital, limit 1); retina: 28.8 nTPM (vital, limit 1); lymph node: 27.7 nTPM (protected, limit 3); cerebellum: 27.4 nTPM (vital, limit 1); choroid plexus: 24.4 nTPM (vital, limit 1); salivary gland: 23.8 nTPM (protected, limit 3); pituitary gland: 22.8 nTPM (vital, limit 1); urinary bladder: 22.5 nTPM (protected, limit 3); small intestine: 22.3 nTPM (vital, limit 1); skin: 22.2 nTPM (manageable, limit 5); kidney: 20.2 nTPM (vital, limit 1); colon: 19.2 nTPM (protected, limit 3); parathyroid gland: 17.2 nTPM (protected, limit 3); thyroid gland: 16.7 nTPM (manageable, limit 5); stomach: 16.3 nTPM (protected, limit 3); smooth muscle: 15.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); duodenum: 12.4 nTPM (vital, limit 1); rectum: 12.1 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AKIRIN2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000135338,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 68.3824% (minimum 75%, Missing); basal ganglia: 68.8889% (minimum 75%, Missing); bone marrow: 72.6562% (minimum 75%, Missing); cerebral cortex: 68.8889% (minimum 75%, Missing); choroid plexus: 40.0862% (minimum 75%, Missing); hippocampal formation: 67.3913% (minimum 75%, Missing); hypothalamus: 69.9248% (minimum 75%, Missing); lung: 70.4545% (minimum 75%, Missing); midbrain: 69.9248% (minimum 75%, Missing); parathyroid gland: 35.7692% (minimum 70%, Missing); pituitary gland: 72.6562% (minimum 75%, Missing); retina: 41.1504% (minimum 75%, Missing); salivary gland: 63.2653% (minimum 70%, Missing); spinal cord: 60.7843% (minimum 75%, Missing); thyroid gland: 60.3896% (minimum 65%, Missing)",-0.0461039,-0.342308,-0.349138,0,5,partial,13.9,16.7,6.1,"parathyroid gland: 16.7 nTPM (protected, limit 3); choroid plexus: 13.9 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); thyroid gland: 6.1 nTPM (manageable, limit 5); spinal cord: 6 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 3); hippocampal formation: 4.5 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 3); lung: 3.9 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 3); bone marrow: 3.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); kidney: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported); caudate / glial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / glandular cells: Low (Supported); duodenum / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); nasopharynx / ciliated cells (tip of cilia): High (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Low (Supported),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LCA5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000135355,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 30.0000% (minimum 75%, Missing)",0.35,0.3,-0.45,0,80,unavailable,0.7,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GJA10,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000135436,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.325983,0.280263,0.217532,0,3,partial,1.5,0.9,1.1,"pancreas: 1.5 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM186B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000135451,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 35.9137% (minimum 75%, Missing); esophagus: 68.1928% (minimum 70%, Missing); thymus: 44.0810% (minimum 65%, Missing)",-0.20919,-0.0180723,-0.390863,0,3,partial,50.5,13.2,35.9,"bone marrow: 50.5 nTPM (vital, limit 1); thymus: 35.9 nTPM (manageable, limit 5); esophagus: 13.2 nTPM (protected, limit 3); lymph node: 11 nTPM (protected, limit 3); rectum: 8.9 nTPM (protected, limit 3); duodenum: 8.7 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); small intestine: 7.3 nTPM (vital, limit 1); spleen: 6.9 nTPM (manageable, limit 5); colon: 6.5 nTPM (protected, limit 3); stomach: 5.2 nTPM (protected, limit 3); smooth muscle: 2.7 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TROAP,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000135537,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 71.7241% (minimum 75%, Missing); heart muscle: 70.7483% (minimum 75%, Missing); kidney: 68.4211% (minimum 75%, Missing); liver: 74.2857% (minimum 75%, Missing); skeletal muscle: 74.8201% (minimum 75%, Missing)",0.131955,0.0209677,-0.0657895,0,5,partial,4.8,5.1,2.9,"parathyroid gland: 5.1 nTPM (protected, limit 4); kidney: 4.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 3); liver: 3.6 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AFG1L,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000135577,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 63.6364% (minimum 75%, Missing); hypothalamus: 70.0000% (minimum 75%, Missing)",0.35,0.175,-0.113636,0,80,unavailable,0.4,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NMBR,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000135625,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 42.2222% (minimum 75%, Missing); basal ganglia: 25.3333% (minimum 75%, Missing); cerebellum: 16.9643% (minimum 75%, Missing); cerebral cortex: 35.5140% (minimum 75%, Missing); hippocampal formation: 28.1481% (minimum 75%, Missing); hypothalamus: 56.7164% (minimum 75%, Missing); pituitary gland: 52.7778% (minimum 75%, Missing)",0.35,0.3,-0.580357,0,0,routine_complete,18.6,0.1,0.2,"cerebellum: 18.6 nTPM (vital, limit 1); basal ganglia: 11.2 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced),56,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EGR4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000135824,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 45.1613% (minimum 75%, Missing); basal ganglia: 9.5563% (minimum 75%, Missing); cerebellum: 23.1405% (minimum 75%, Missing); cerebral cortex: 45.9016% (minimum 60%, Enhanced); hippocampal formation: 54.9020% (minimum 75%, Missing); hypothalamus: 31.4607% (minimum 75%, Missing); midbrain: 25.6881% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 8.6687% (minimum 75%, Missing); spinal cord: 40.5797% (minimum 75%, Missing); thyroid gland: 30.4348% (minimum 50%, Enhanced)",-0.195652,0.265517,-0.663313,0,7,partial,29.5,0.1,6.4,"retina: 29.5 nTPM (vital, limit 1); basal ganglia: 26.5 nTPM (vital, limit 1); cerebellum: 9.3 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); spinal cord: 4.1 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RGS8,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000135829,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.9955% (minimum 65%, Missing); adrenal gland: 63.5018% (minimum 75%, Missing); amygdala: 73.6767% (minimum 75%, Missing); basal ganglia: 70.4514% (minimum 75%, Missing); bone marrow: 28.4060% (minimum 75%, Missing); cerebellum: 58.7900% (minimum 75%, Missing); cerebral cortex: 58.0609% (minimum 75%, Missing); choroid plexus: 70.5479% (minimum 75%, Missing); colon: 56.9690% (minimum 70%, Missing); duodenum: 61.8990% (minimum 75%, Missing); esophagus: 62.2733% (minimum 70%, Missing); heart muscle: 65.1899% (minimum 75%, Missing); hypothalamus: 73.0496% (minimum 75%, Missing); kidney: 51.6550% (minimum 75%, Missing); liver: 58.9920% (minimum 75%, Missing); lung: 57.9303% (minimum 75%, Missing); lymph node: 48.0859% (minimum 70%, Missing); midbrain: 74.3146% (minimum 75%, Missing); pancreas: 63.5018% (minimum 75%, Missing); parathyroid gland: 43.8298% (minimum 70%, Missing); pituitary gland: 71.5278% (minimum 75%, Missing); rectum: 52.9835% (minimum 70%, Missing); retina: 44.4349% (minimum 75%, Missing); salivary gland: 61.9735% (minimum 70%, Missing); skeletal muscle: 63.8166% (minimum 75%, Missing); skin: 62.9584% (minimum 65%, Missing); small intestine: 59.3318% (minimum 75%, Missing); smooth muscle: 51.2948% (minimum 75%, Missing); spinal cord: 69.7832% (minimum 75%, Missing); spleen: 56.4074% (minimum 65%, Missing); stomach: 60.5170% (minimum 70%, Missing); thymus: 37.3730% (minimum 65%, Missing); thyroid gland: 52.4975% (minimum 65%, Missing); tongue: 58.6560% (minimum 70%, Missing); urinary bladder: 49.7585% (minimum 70%, Missing)",-0.27627,-0.261702,-0.46594,0,4,partial,129.8,66,86.3,"bone marrow: 129.8 nTPM (vital, limit 1); thymus: 86.3 nTPM (manageable, limit 5); parathyroid gland: 66 nTPM (protected, limit 3); retina: 64.4 nTPM (vital, limit 1); lymph node: 55.6 nTPM (protected, limit 3); urinary bladder: 52 nTPM (protected, limit 3); smooth muscle: 48.9 nTPM (vital, limit 1); kidney: 48.2 nTPM (vital, limit 1); thyroid gland: 46.6 nTPM (manageable, limit 5); rectum: 45.7 nTPM (protected, limit 3); spleen: 39.8 nTPM (manageable, limit 5); colon: 38.9 nTPM (protected, limit 3); lung: 37.4 nTPM (vital, limit 1); adipose tissue: 37.3 nTPM (manageable, limit 5); cerebral cortex: 37.2 nTPM (vital, limit 1); tongue: 36.3 nTPM (protected, limit 3); cerebellum: 36.1 nTPM (vital, limit 1); liver: 35.8 nTPM (vital, limit 1); small intestine: 35.3 nTPM (vital, limit 1); stomach: 33.6 nTPM (protected, limit 3); duodenum: 31.7 nTPM (vital, limit 1); salivary gland: 31.6 nTPM (protected, limit 3); esophagus: 31.2 nTPM (protected, limit 3); skin: 30.3 nTPM (manageable, limit 5); adrenal gland: 29.6 nTPM (vital, limit 1); pancreas: 29.6 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 1); heart muscle: 27.5 nTPM (vital, limit 1); spinal cord: 22.3 nTPM (vital, limit 1); basal ganglia: 21.6 nTPM (vital, limit 1); choroid plexus: 21.5 nTPM (vital, limit 1); pituitary gland: 20.5 nTPM (vital, limit 1); hypothalamus: 19 nTPM (vital, limit 1); amygdala: 18.4 nTPM (vital, limit 1); midbrain: 17.8 nTPM (vital, limit 1); hippocampal formation: 17.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DHX9,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000135898,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 56.2500% (minimum 75%, Missing); lymph node: 61.6438% (minimum 70%, Missing); small intestine: 68.1818% (minimum 75%, Missing); spleen: 52.9412% (minimum 65%, Missing)",-0.120588,-0.0835616,-0.1875,0,80,unavailable,3.5,2.8,4,"basal ganglia: 3.5 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GPR55,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000135913,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 51.6807% (minimum 70%, Approved); lymph node: 67.9558% (minimum 70%, Missing); retina: 58.8517% (minimum 75%, Missing)",0.0184783,-0.020442,-0.183193,0,6,partial,11.5,5.8,6.1,"bone marrow: 11.5 nTPM (vital, limit 2); retina: 8.6 nTPM (vital, limit 1); thymus: 6.1 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 3); tongue: 4.1 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 3); esophagus: 3.8 nTPM (protected, limit 3); liver: 3.7 nTPM (vital, limit 1); salivary gland: 3.7 nTPM (protected, limit 3); cerebral cortex: 3.7 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 3); rectum: 3.4 nTPM (protected, limit 3); stomach: 3.3 nTPM (protected, limit 3); small intestine: 3.3 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 2); heart muscle: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,USP37,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000135951,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.293503,0.27093,0.191729,0,80,unavailable,3.1,1.5,3,"choroid plexus: 3.1 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TSGA10,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000135960,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"colon: 53.8462% (minimum 70%, Missing); duodenum: 58.3333% (minimum 75%, Missing); esophagus: 28.5714% (minimum 70%, Missing); kidney: 70.0000% (minimum 75%, Missing); liver: 60.8696% (minimum 75%, Missing); lymph node: 48.2759% (minimum 70%, Missing); rectum: 42.4242% (minimum 70%, Missing); skin: 50.0000% (minimum 65%, Missing); small intestine: 58.3333% (minimum 75%, Missing); stomach: 63.6364% (minimum 70%, Missing); thymus: 56.0000% (minimum 65%, Missing); urinary bladder: 50.0000% (minimum 70%, Missing)",-0.15,-0.414286,-0.166667,0,4,partial,1,3.5,1.4,"esophagus: 3.5 nTPM (protected, limit 3)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EDAR,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000136014,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.217159,0.236255,0.107664,0,80,unavailable,3.9,1.6,3.6,"cerebellum: 3.9 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,USP44,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000136197,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.1111% (minimum 75%, Missing); amygdala: 64.0000% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 65.3061% (minimum 75%, Missing); cerebral cortex: 61.5385% (minimum 75%, Missing); choroid plexus: 65.3061% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 61.5385% (minimum 75%, Missing); hippocampal formation: 65.3061% (minimum 75%, Missing); hypothalamus: 60.3774% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); liver: 69.5652% (minimum 75%, Missing); lung: 69.5652% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); midbrain: 59.2593% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 54.2373% (minimum 70%, Missing); pituitary gland: 69.5652% (minimum 75%, Missing); retina: 68.0851% (minimum 75%, Missing); salivary gland: 68.0851% (minimum 70%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing); small intestine: 72.7273% (minimum 75%, Missing); smooth muscle: 65.3061% (minimum 70%, Approved); spinal cord: 59.2593% (minimum 75%, Missing); stomach: 64.0000% (minimum 70%, Missing); thyroid gland: 54.2373% (minimum 65%, Missing); tongue: 62.7451% (minimum 70%, Missing)",-0.107627,-0.157627,-0.178571,0,2,partial,2.4,2.7,2.7,"kidney: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C7orf25,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000136206,True,compatible,,True,True,True,,0.298101,0.3,0.167073,0,3,partial,1.5,0.6,1.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPDYE1,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,True,True,True,False,gained,selectivity_revised
ENSG00000136231,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.29898,0.171875,0.225524,0,4,partial,0.7,4.1,1.5,"lymph node: 4.1 nTPM (protected, limit 3)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IGF2BP3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,"Bradley et al., Nature Communications (2020);Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016",False,False,False,False,False,unchanged,
ENSG00000136327,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"spinal cord: 50.3268% (minimum 75%, Missing)",0.196154,0.054902,-0.246732,0,80,unavailable,7.6,2.5,1.4,"spinal cord: 7.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NKX2-8,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000136449,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.339045,0.285959,0.176686,0,6,partial,5,0.9,1,"choroid plexus: 5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MYCBPAP,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000136487,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pituitary gland: 55.4114% (minimum 75%, Missing)",0.35,0.3,-0.195886,0,1,partial,99.7,0.2,0.2,"pituitary gland: 99.7 nTPM (vital, limit 1)",pituitary gland / cells in anterior : High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GH2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000136488,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.349916,0.3,0.249979,0,2,partial,38.3,19.4,25.4,"smooth muscle: 38.3 nTPM (vital, limit 6); stomach: 19.4 nTPM (protected, limit 12); lung: 10.4 nTPM (vital, limit 6)",pituitary gland / cells in anterior : High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CSH1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · testis-biased",False,False,False,False,False,unchanged,
ENSG00000136492,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 63.5135% (minimum 75%, Missing); thymus: 56.6265% (minimum 65%, Missing)",-0.0837349,0.0833333,-0.114865,0,10,partial,2.7,1.3,3.6,"bone marrow: 2.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BRIP1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000136603,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0000% (minimum 65%, Missing); adrenal gland: 53.5714% (minimum 75%, Missing); amygdala: 73.7705% (minimum 75%, Missing); basal ganglia: 72.1925% (minimum 75%, Missing); bone marrow: 36.9863% (minimum 75%, Missing); cerebral cortex: 53.7849% (minimum 75%, Missing); colon: 57.2034% (minimum 70%, Missing); duodenum: 50.1859% (minimum 75%, Missing); esophagus: 60.2679% (minimum 70%, Missing); heart muscle: 53.7849% (minimum 75%, Uncertain); hippocampal formation: 72.1925% (minimum 75%, Missing); hypothalamus: 71.8085% (minimum 75%, Missing); kidney: 57.6923% (minimum 75%, Missing); liver: 47.2028% (minimum 75%, Missing); lung: 46.3918% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Uncertain); midbrain: 71.0526% (minimum 75%, Missing); pancreas: 59.2105% (minimum 75%, Uncertain); pituitary gland: 55.7851% (minimum 75%, Missing); rectum: 58.9520% (minimum 70%, Missing); retina: 59.2105% (minimum 75%, Missing); salivary gland: 65.2174% (minimum 70%, Missing); skeletal muscle: 55.7851% (minimum 75%, Missing); small intestine: 49.4505% (minimum 75%, Missing); smooth muscle: 57.2034% (minimum 75%, Uncertain); spinal cord: 68.1818% (minimum 75%, Missing); stomach: 46.5517% (minimum 70%, Missing); thymus: 60.0000% (minimum 65%, Missing); thyroid gland: 55.1020% (minimum 65%, Missing); tongue: 39.5894% (minimum 70%, Missing); urinary bladder: 48.9130% (minimum 70%, Missing)",-0.11,-0.304106,-0.380137,0,1,partial,23,20.6,11.5,"bone marrow: 23 nTPM (vital, limit 1); tongue: 20.6 nTPM (protected, limit 3); lung: 15.6 nTPM (vital, limit 1); stomach: 15.5 nTPM (protected, limit 3); liver: 15.1 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 3); small intestine: 13.8 nTPM (vital, limit 1); lymph node: 13.5 nTPM (protected, limit 3); duodenum: 13.4 nTPM (vital, limit 1); adrenal gland: 11.7 nTPM (vital, limit 1); cerebral cortex: 11.6 nTPM (vital, limit 1); heart muscle: 11.6 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (manageable, limit 5); thyroid gland: 11 nTPM (manageable, limit 5); pituitary gland: 10.7 nTPM (vital, limit 1); skeletal muscle: 10.7 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 3); kidney: 9.9 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 3); pancreas: 9.3 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); thymus: 9 nTPM (manageable, limit 5); esophagus: 8.9 nTPM (protected, limit 3); salivary gland: 7.2 nTPM (protected, limit 3); spleen: 7 nTPM (manageable, limit 5); spinal cord: 6.3 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); midbrain: 5.5 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 3); hypothalamus: 5.3 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SKIL,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000136811,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.277584,0.254841,0.144005,0,13,partial,36.6,17.5,24.1,"choroid plexus: 36.6 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 6); pituitary gland: 29.8 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); bone marrow: 22.3 nTPM (vital, limit 6); lymph node: 17.5 nTPM (protected, limit 12); urinary bladder: 16.1 nTPM (protected, limit 12); liver: 16 nTPM (vital, limit 6); colon: 14.6 nTPM (protected, limit 3); smooth muscle: 13.8 nTPM (vital, limit 6); kidney: 13.7 nTPM (vital, limit 6); lung: 13.6 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 12); small intestine: 13 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 6); pancreas: 11.5 nTPM (vital, limit 6); cerebral cortex: 11.1 nTPM (vital, limit 6); hypothalamus: 10.9 nTPM (vital, limit 1); rectum: 10 nTPM (protected, limit 3); adrenal gland: 9.7 nTPM (vital, limit 6); hippocampal formation: 9.6 nTPM (vital, limit 1); spinal cord: 9.4 nTPM (vital, limit 1); retina: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); skeletal muscle: 7.6 nTPM (vital, limit 6); duodenum: 7.4 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 3)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),85,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ODF2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000136866,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 60.7477% (minimum 75%, Missing); cerebral cortex: 65.0000% (minimum 75%, Missing); kidney: 74.7126% (minimum 75%, Missing); parathyroid gland: 69.8925% (minimum 70%, Missing); pituitary gland: 63.7255% (minimum 75%, Missing); retina: 51.5873% (minimum 75%, Missing); smooth muscle: 73.0337% (minimum 75%, Missing); spinal cord: 73.0337% (minimum 75%, Missing)",0.0489247,-0.00107527,-0.234127,0,80,unavailable,6.1,2.8,2.8,"retina: 6.1 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZFP37,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000136929,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 16.7749% (minimum 75%, Missing)",0.147078,0.297967,-0.582251,0,2,partial,243.6,1.5,12.5,"bone marrow: 243.6 nTPM (vital, limit 1); thymus: 12.5 nTPM (manageable, limit 5)",bone marrow / hematopoietic cells: High (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HEMGN,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000136944,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 67.7966% (minimum 75%, Missing); kidney: 53.3333% (minimum 75%, Missing); midbrain: 52.6316% (minimum 75%, Missing); salivary gland: 18.1818% (minimum 70%, Missing)",0.0166667,-0.518182,-0.223684,0,80,unavailable,3.6,18,2,"salivary gland: 18 nTPM (protected, limit 3); midbrain: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LMX1B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000137090,True,compatible,,True,True,True,,0.35,0.3,0.238636,0,2,partial,0.3,0,0.2,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DMRT1,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000137225,True,compatible,,True,True,True,,0.283544,0.296622,0.246622,0,3,partial,0.4,0.4,2.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CAPN11,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000137270,True,compatible,,True,True,True,,0.35,0.3,0.234848,0,5,partial,3.4,0.2,0.4,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GCM1,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,True,True,True,False,gained,selectivity_revised
ENSG00000137434,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.260959,0.198649,0.00568182,0,80,unavailable,4.3,1.5,1.3,"amygdala: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C6orf52,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000137473,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.348569,0.291477,0.172061,0,0,routine_complete,5.9,0.6,0.1,"choroid plexus: 5.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / melanocytes,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TTC29,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000137674,True,compatible,,True,True,True,,0.35,0.3,0.107143,0,80,unavailable,0.1,0,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MMP20,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000137691,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 55.3875% (minimum 75%, Missing)",0.329933,0.3,-0.196125,0,3,partial,23.6,2.9,3.5,"choroid plexus: 23.6 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP300,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000137707,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345475,0.3,0.0865019,0,80,unavailable,4.3,0,0.1,"choroid plexus: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BTG4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000137770,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.9130% (minimum 75%, Missing); bone marrow: 50.2463% (minimum 75%, Missing); cerebellum: 69.3878% (minimum 70%, Approved); cerebral cortex: 66.6667% (minimum 75%, Missing); colon: 66.0194% (minimum 70%, Missing); duodenum: 67.7741% (minimum 75%, Missing); esophagus: 62.7692% (minimum 70%, Missing); heart muscle: 68.9189% (minimum 75%, Missing); kidney: 66.2338% (minimum 75%, Missing); liver: 67.1053% (minimum 75%, Missing); lung: 66.8852% (minimum 75%, Missing); lymph node: 51.9084% (minimum 70%, Missing); pancreas: 64.5570% (minimum 75%, Missing); parathyroid gland: 65.5949% (minimum 70%, Missing); rectum: 65.1757% (minimum 70%, Missing); retina: 58.1197% (minimum 75%, Missing); salivary gland: 69.6246% (minimum 70%, Missing); small intestine: 62.1951% (minimum 75%, Missing); smooth muscle: 60.3550% (minimum 70%, Approved); spleen: 61.2613% (minimum 65%, Missing); stomach: 68.2274% (minimum 70%, Missing); thymus: 45.3333% (minimum 65%, Missing); thyroid gland: 58.2857% (minimum 60%, Approved); tongue: 69.1525% (minimum 70%, Missing); urinary bladder: 63.3540% (minimum 70%, Missing)",-0.196667,-0.180916,-0.247537,0,5,partial,20.2,18.9,24.6,"thymus: 24.6 nTPM (manageable, limit 5); bone marrow: 20.2 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 3); retina: 14.7 nTPM (vital, limit 1); thyroid gland: 14.6 nTPM (manageable, limit 10); smooth muscle: 13.4 nTPM (vital, limit 2); spleen: 12.9 nTPM (manageable, limit 5); small intestine: 12.4 nTPM (vital, limit 1); esophagus: 12.1 nTPM (protected, limit 3); urinary bladder: 11.8 nTPM (protected, limit 3); pancreas: 11.2 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 3); parathyroid gland: 10.7 nTPM (protected, limit 3); colon: 10.5 nTPM (protected, limit 3); kidney: 10.4 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); liver: 10 nTPM (vital, limit 1); duodenum: 9.7 nTPM (vital, limit 1); stomach: 9.5 nTPM (protected, limit 3); heart muscle: 9.2 nTPM (vital, limit 1); tongue: 9.1 nTPM (protected, limit 3); cerebellum: 9 nTPM (vital, limit 2); salivary gland: 8.9 nTPM (protected, limit 3); skin: 7.9 nTPM (manageable, limit 5); adrenal gland: 7.2 nTPM (vital, limit 1); skeletal muscle: 5.2 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: High (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CTDSPL2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000137812,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0449153,0.124121,0.0127907,0,2,partial,5.1,3.5,7.2,"thymus: 7.2 nTPM (manageable, limit 5); bone marrow: 5.1 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KNL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000137843,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.2540% (minimum 70%, Approved); amygdala: 43.5443% (minimum 75%, Missing); basal ganglia: 43.1078% (minimum 75%, Missing); cerebellum: 46.2366% (minimum 70%, Approved); cerebral cortex: 35.1020% (minimum 75%, Missing); esophagus: 40.8551% (minimum 70%, Missing); heart muscle: 68.2540% (minimum 75%, Missing); hippocampal formation: 49.4253% (minimum 75%, Missing); hypothalamus: 67.9842% (minimum 75%, Missing); pancreas: 68.8000% (minimum 70%, Approved); pituitary gland: 59.3103% (minimum 75%, Missing); skin: 38.6517% (minimum 65%, Missing)",-0.263483,-0.291449,-0.39898,0,1,partial,31.8,24.9,27.3,"cerebral cortex: 31.8 nTPM (vital, limit 1); skin: 27.3 nTPM (manageable, limit 5); esophagus: 24.9 nTPM (protected, limit 3); basal ganglia: 22.7 nTPM (vital, limit 1); amygdala: 22.3 nTPM (vital, limit 1); cerebellum: 20 nTPM (vital, limit 2); hippocampal formation: 17.6 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 2); heart muscle: 8 nTPM (vital, limit 1); pancreas: 7.8 nTPM (vital, limit 2); parathyroid gland: 7.7 nTPM (protected, limit 4); thyroid gland: 7.2 nTPM (manageable, limit 5); salivary gland: 6 nTPM (protected, limit 4); kidney: 4.6 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 2); midbrain: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); thyroid gland / glandular cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PAK6,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000137869,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348343,0.297517,0.245045,0,1,partial,8.2,3.3,8,"adrenal gland: 8.2 nTPM (vital, limit 6)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CYP19A1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000137948,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348435,0.299217,0.247654,0,6,partial,2.6,0.4,0.4,"bone marrow: 2.6 nTPM (vital, limit 2)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BRDT,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000137968,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 72.9730% (minimum 75%, Missing); cerebral cortex: 62.7907% (minimum 75%, Missing); esophagus: 45.7627% (minimum 70%, Missing); heart muscle: 69.2308% (minimum 75%, Missing); hippocampal formation: 70.1299% (minimum 75%, Missing); hypothalamus: 69.2308% (minimum 75%, Missing); kidney: 73.9726% (minimum 75%, Missing); midbrain: 73.9726% (minimum 75%, Missing); parathyroid gland: 60.0000% (minimum 70%, Missing); pituitary gland: 63.5294% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 69.2308% (minimum 75%, Missing); skin: 34.1772% (minimum 65%, Missing)",-0.308228,-0.242373,-0.122093,0,80,unavailable,3.2,6.4,10.4,"skin: 10.4 nTPM (manageable, limit 5); esophagus: 6.4 nTPM (protected, limit 3); parathyroid gland: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC44A5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000137976,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lung: 73.8636% (minimum 75%, Missing); salivary gland: 3.7835% (minimum 70%, Missing)",0.278571,-0.662165,-0.0113636,0,80,unavailable,2.3,165.3,0.5,"salivary gland: 165.3 nTPM (protected, limit 3); lung: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNASE2B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000138068,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.2,0.107143,0,80,unavailable,0.3,0.2,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,SULT6B1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000138092,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.3636% (minimum 65%, Missing); adrenal gland: 67.5000% (minimum 75%, Missing); amygdala: 65.8537% (minimum 75%, Missing); basal ganglia: 65.8537% (minimum 75%, Missing); bone marrow: 47.0930% (minimum 75%, Missing); cerebellum: 66.9421% (minimum 75%, Missing); cerebral cortex: 62.7907% (minimum 75%, Missing); duodenum: 72.3214% (minimum 75%, Missing); esophagus: 64.8000% (minimum 70%, Missing); heart muscle: 75.0000% (minimum 75%, Missing); hippocampal formation: 65.3226% (minimum 75%, Missing); hypothalamus: 66.9421% (minimum 75%, Missing); kidney: 74.3119% (minimum 75%, Missing); lung: 69.8276% (minimum 75%, Missing); lymph node: 62.7907% (minimum 70%, Missing); midbrain: 66.9421% (minimum 75%, Missing); pituitary gland: 69.8276% (minimum 75%, Missing); rectum: 69.2308% (minimum 70%, Missing); skeletal muscle: 73.6364% (minimum 75%, Missing); small intestine: 68.0672% (minimum 75%, Missing); spinal cord: 68.6441% (minimum 75%, Missing); thymus: 42.1875% (minimum 65%, Missing)",-0.228125,-0.072093,-0.27907,0,80,unavailable,9.1,4.8,11.1,"thymus: 11.1 nTPM (manageable, limit 5); bone marrow: 9.1 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (manageable, limit 5); lymph node: 4.8 nTPM (protected, limit 3); cerebral cortex: 4.8 nTPM (vital, limit 1); esophagus: 4.4 nTPM (protected, limit 3); hippocampal formation: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); lung: 3.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); duodenum: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CENPO,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000138115,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 62.9032% (minimum 75%, Missing); hippocampal formation: 73.5849% (minimum 75%, Missing); hypothalamus: 60.9375% (minimum 75%, Missing); liver: 0.1864% (minimum 75%, Missing); pituitary gland: 56.5217% (minimum 75%, Missing); retina: 56.5217% (minimum 75%, Missing); stomach: 40.2062% (minimum 55%, Enhanced)",0.295918,-0.147938,-0.748136,0,6,partial,2088.7,5.8,1,"liver: 2088.7 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",colon / enterocytes: Low (Enhanced); liver / hepatocytes: High (Enhanced); small intestine / enterocytes: Low (Enhanced),68,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CYP2C8,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000138182,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 39.8810% (minimum 75%, Missing); colon: 68.3673% (minimum 70%, Missing); esophagus: 68.3673% (minimum 70%, Missing); lymph node: 46.2069% (minimum 70%, Missing); rectum: 63.2075% (minimum 70%, Missing); thymus: 41.1043% (minimum 65%, Missing)",-0.238957,-0.237931,-0.35119,0,9,partial,10.1,7.8,9.6,"bone marrow: 10.1 nTPM (vital, limit 1); thymus: 9.6 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 3); rectum: 3.9 nTPM (protected, limit 3); duodenum: 3.5 nTPM (vital, limit 3); small intestine: 3.3 nTPM (vital, limit 3); colon: 3.1 nTPM (protected, limit 3); esophagus: 3.1 nTPM (protected, limit 3); liver: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / endothelial cells: Low (Supported); colon / glandular cells: Low (Supported); esophagus / squamous epithelial cells: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Low (Supported); liver / hepatocytes: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); rectum / glandular cells: Low (Supported); salivary gland / glandular cells: Medium (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / fibrohistiocytic cells: Low (Supported); skin 1 / lymphocytes: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: Low (Supported); skin 2 / fibrohistiocytic cells: Low (Supported); skin 2 / lymphocytes: Low (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KIF20B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000138336,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 66.6667% (minimum 75%, Missing); cerebral cortex: 63.1579% (minimum 75%, Missing); parathyroid gland: 63.1579% (minimum 70%, Missing); retina: 44.4444% (minimum 75%, Missing); salivary gland: 54.5455% (minimum 70%, Missing); skeletal muscle: 60.0000% (minimum 75%, Missing); smooth muscle: 70.5882% (minimum 75%, Missing); spinal cord: 70.5882% (minimum 75%, Missing); thymus: 38.7097% (minimum 65%, Missing)",-0.262903,-0.154545,-0.305556,0,80,unavailable,1.5,1,1.9,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TET1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000138379,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.1429% (minimum 70%, Approved); amygdala: 63.1579% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 60.0000% (minimum 70%, Approved); cerebral cortex: 63.1579% (minimum 70%, Approved); esophagus: 54.5455% (minimum 65%, Approved); hippocampal formation: 63.1579% (minimum 75%, Missing); hypothalamus: 63.1579% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 28.5714% (minimum 75%, Missing); skeletal muscle: 11.0092% (minimum 70%, Approved); tongue: 7.5472% (minimum 70%, Missing)",0.105882,-0.624528,-0.589908,0,2,partial,9.7,14.7,0.5,"tongue: 14.7 nTPM (protected, limit 3); skeletal muscle: 9.7 nTPM (vital, limit 2); retina: 3 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MSTN,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000138380,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 74.1135% (minimum 75%, Missing); retina: 57.2603% (minimum 75%, Missing); spinal cord: 74.6429% (minimum 75%, Missing)",0.0198718,0.00847458,-0.177397,0,3,partial,15.6,8.6,10.3,"retina: 15.6 nTPM (vital, limit 1); thyroid gland: 10.3 nTPM (manageable, limit 5); thymus: 9.2 nTPM (manageable, limit 5); lymph node: 8.6 nTPM (protected, limit 3); parathyroid gland: 7.6 nTPM (protected, limit 3); spleen: 7.3 nTPM (manageable, limit 5); cerebral cortex: 7.3 nTPM (vital, limit 1); spinal cord: 7.1 nTPM (vital, limit 1); skin: 7.1 nTPM (manageable, limit 5); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.4 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 3); rectum: 5.8 nTPM (protected, limit 3); urinary bladder: 5.5 nTPM (protected, limit 3); bone marrow: 5.3 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 3); tongue: 5.2 nTPM (protected, limit 3); adrenal gland: 5.1 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 3); pituitary gland: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); small intestine: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); cerebellum: 4.6 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 3); duodenum: 4.4 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); liver: 4.3 nTPM (vital, limit 1); amygdala: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CARF,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000138400,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 53.9683% (minimum 75%, Missing); pituitary gland: 72.5610% (minimum 75%, Missing); retina: 74.1433% (minimum 75%, Missing)",0.235088,0.206115,-0.210317,0,7,partial,20.3,4,4.7,"choroid plexus: 20.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); retina: 8.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); kidney: 3 nTPM (vital, limit 2); hippocampal formation: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 2); amygdala: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MDH1B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000138483,True,compatible,,True,True,True,,0.349123,0.3,0.243892,0,80,unavailable,0.7,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC54,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000138587,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 68.0233% (minimum 75%, Missing)",0.246552,0.247368,-0.0697674,0,80,unavailable,22,2.6,5.4,"choroid plexus: 22 nTPM (vital, limit 1); kidney: 10.2 nTPM (vital, limit 1); cerebellum: 7.5 nTPM (vital, limit 1); thymus: 5.4 nTPM (manageable, limit 5); bone marrow: 4.5 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MNS1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000138646,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.156313,0.222824,0.100227,0,3,partial,18.6,11.6,13.5,"bone marrow: 18.6 nTPM (vital, limit 3); thymus: 13.5 nTPM (manageable, limit 5); smooth muscle: 13 nTPM (vital, limit 3); salivary gland: 11.6 nTPM (protected, limit 6); choroid plexus: 9.9 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 6); pancreas: 7.5 nTPM (vital, limit 3); lymph node: 7 nTPM (protected, limit 6); lung: 6.3 nTPM (vital, limit 3); kidney: 6.2 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 3); small intestine: 4.5 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 3); heart muscle: 3.8 nTPM (vital, limit 3); colon: 3.8 nTPM (protected, limit 3); amygdala: 3.6 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 3); cerebral cortex: 3.1 nTPM (vital, limit 3); hippocampal formation: 3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Supported); colon / glandular cells: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in tubules: Low (Supported); liver / hepatocytes: Low (Supported); rectum / glandular cells: Low (Supported); small intestine / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HERC5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000138669,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"duodenum: 49.4845% (minimum 75%, Missing); heart muscle: 69.0647% (minimum 75%, Missing); lung: 73.8462% (minimum 75%, Missing); small intestine: 41.9214% (minimum 75%, Missing)",0.247196,0.068,-0.330786,0,0,routine_complete,13.3,2.9,1.1,"small intestine: 13.3 nTPM (vital, limit 1); duodenum: 9.8 nTPM (vital, limit 1); heart muscle: 4.3 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRKG2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000138684,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lymph node: 10.7692% (minimum 70%, Missing)",0.225,-0.592308,0.25,0,80,unavailable,0,5.8,0.1,"lymph node: 5.8 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IL21,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000138688,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.8580% (minimum 60%, Approved); adrenal gland: 62.6168% (minimum 70%, Approved); amygdala: 55.2198% (minimum 75%, Missing); basal ganglia: 50.6297% (minimum 75%, Missing); bone marrow: 51.2102% (minimum 70%, Approved); cerebellum: 48.6683% (minimum 70%, Approved); cerebral cortex: 52.3438% (minimum 70%, Approved); choroid plexus: 54.9180% (minimum 75%, Missing); colon: 58.4302% (minimum 70%, Missing); heart muscle: 64.5265% (minimum 75%, Missing); hippocampal formation: 54.9180% (minimum 75%, Missing); hypothalamus: 58.7719% (minimum 75%, Missing); kidney: 62.0370% (minimum 75%, Missing); liver: 69.3103% (minimum 70%, Approved); lung: 59.7325% (minimum 75%, Missing); midbrain: 54.3243% (minimum 75%, Missing); pancreas: 62.6168% (minimum 75%, Missing); parathyroid gland: 49.5684% (minimum 65%, Approved); pituitary gland: 46.6899% (minimum 75%, Missing); retina: 39.9602% (minimum 75%, Missing); salivary gland: 64.9435% (minimum 65%, Approved); skeletal muscle: 50.0623% (minimum 70%, Approved); small intestine: 59.4675% (minimum 75%, Missing); smooth muscle: 74.4444% (minimum 75%, Missing); spinal cord: 50.0623% (minimum 75%, Missing); stomach: 64.1148% (minimum 70%, Missing); thyroid gland: 57.0213% (minimum 65%, Missing); tongue: 54.9932% (minimum 70%, Missing); urinary bladder: 62.9108% (minimum 70%, Missing)",-0.0797872,-0.154316,-0.350398,0,7,partial,60.4,40.9,30.3,"retina: 60.4 nTPM (vital, limit 1); pituitary gland: 45.9 nTPM (vital, limit 1); cerebellum: 42.4 nTPM (vital, limit 2); parathyroid gland: 40.9 nTPM (protected, limit 4); spinal cord: 40.1 nTPM (vital, limit 1); skeletal muscle: 40.1 nTPM (vital, limit 2); basal ganglia: 39.2 nTPM (vital, limit 1); bone marrow: 38.3 nTPM (vital, limit 2); cerebral cortex: 36.6 nTPM (vital, limit 2); midbrain: 33.8 nTPM (vital, limit 1); hippocampal formation: 33 nTPM (vital, limit 1); choroid plexus: 33 nTPM (vital, limit 1); tongue: 32.9 nTPM (protected, limit 3); amygdala: 32.6 nTPM (vital, limit 1); thyroid gland: 30.3 nTPM (manageable, limit 5); colon: 28.6 nTPM (protected, limit 3); hypothalamus: 28.2 nTPM (vital, limit 1); adipose tissue: 28.1 nTPM (manageable, limit 10); small intestine: 27.4 nTPM (vital, limit 1); lung: 27.1 nTPM (vital, limit 1); spleen: 25.7 nTPM (manageable, limit 10); kidney: 24.6 nTPM (vital, limit 1); pancreas: 24 nTPM (vital, limit 1); adrenal gland: 24 nTPM (vital, limit 2); urinary bladder: 23.7 nTPM (protected, limit 3); stomach: 22.5 nTPM (protected, limit 3); heart muscle: 22.1 nTPM (vital, limit 1); salivary gland: 21.7 nTPM (protected, limit 4); skin: 21.5 nTPM (manageable, limit 5); liver: 17.8 nTPM (vital, limit 2); esophagus: 16.9 nTPM (protected, limit 4); thymus: 16.4 nTPM (manageable, limit 5); rectum: 14 nTPM (protected, limit 3); smooth muscle: 13.8 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 4); duodenum: 11.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BLTP1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000138778,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 28.7770% (minimum 75%, Missing); duodenum: 72.7273% (minimum 75%, Missing); esophagus: 67.7966% (minimum 70%, Missing); lymph node: 42.1053% (minimum 70%, Missing); rectum: 67.7966% (minimum 70%, Missing); thymus: 31.0078% (minimum 65%, Missing)",-0.339922,-0.278947,-0.46223,0,7,partial,9.9,5.5,8.9,"bone marrow: 9.9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 3); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Low (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / eccrine glands: High (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CENPE,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000138780,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 66.8790% (minimum 75%, Missing); esophagus: 68.6275% (minimum 70%, Missing); kidney: 71.4286% (minimum 75%, Missing); retina: 59.6591% (minimum 75%, Missing); smooth muscle: 72.9167% (minimum 75%, Missing)",0.0187898,-0.0137255,-0.153409,0,5,partial,7.1,4.8,5.2,"retina: 7.1 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); bone marrow: 5.2 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 3); lymph node: 4.5 nTPM (protected, limit 3); kidney: 4.2 nTPM (vital, limit 1); smooth muscle: 3.9 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); colon: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 3); stomach: 3.2 nTPM (protected, limit 3); pancreas: 3.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GSTCD,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000138813,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C4orf17,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000138892,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TTLL8,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000139133,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 55.9322% (minimum 75%, Missing); bone marrow: 45.2055% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); duodenum: 67.3469% (minimum 75%, Missing); esophagus: 61.1111% (minimum 70%, Missing); kidney: 64.7059% (minimum 75%, Missing); liver: 54.0984% (minimum 75%, Missing); lung: 64.7059% (minimum 75%, Missing); lymph node: 47.8261% (minimum 70%, Missing); pancreas: 68.7500% (minimum 75%, Missing); parathyroid gland: 60.0000% (minimum 70%, Missing); rectum: 63.4615% (minimum 70%, Missing); retina: 50.7692% (minimum 75%, Missing); salivary gland: 68.7500% (minimum 70%, Missing); skin: 63.4615% (minimum 65%, Missing); small intestine: 66.0000% (minimum 75%, Missing); smooth muscle: 61.1111% (minimum 75%, Missing); spleen: 54.0984% (minimum 65%, Missing); stomach: 63.4615% (minimum 70%, Missing); thymus: 48.5294% (minimum 65%, Missing); thyroid gland: 55.0000% (minimum 65%, Missing)",-0.164706,-0.221739,-0.297945,0,1,partial,4,3.6,3.5,"bone marrow: 4 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 3); retina: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ALG10,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000139151,True,compatible,,True,True,True,,0.31028,0.290361,0.240361,0,80,unavailable,0.4,0.4,1.7,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PLCZ1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000139160,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 57.9545% (minimum 75%, Missing); amygdala: 71.8310% (minimum 75%, Missing); basal ganglia: 68.0000% (minimum 75%, Missing); bone marrow: 69.8630% (minimum 75%, Uncertain); cerebellum: 65.3846% (minimum 75%, Missing); cerebral cortex: 68.9189% (minimum 75%, Missing); choroid plexus: 65.3846% (minimum 75%, Missing); colon: 68.9189% (minimum 70%, Missing); duodenum: 64.5570% (minimum 75%, Missing); esophagus: 68.9189% (minimum 70%, Missing); heart muscle: 59.3023% (minimum 75%, Missing); hippocampal formation: 71.8310% (minimum 75%, Missing); hypothalamus: 71.8310% (minimum 75%, Missing); kidney: 46.3636% (minimum 75%, Missing); liver: 35.1724% (minimum 75%, Missing); lung: 71.8310% (minimum 75%, Missing); midbrain: 71.8310% (minimum 75%, Missing); pancreas: 60.7143% (minimum 75%, Missing); parathyroid gland: 52.5773% (minimum 70%, Missing); pituitary gland: 67.1053% (minimum 75%, Missing); rectum: 68.0000% (minimum 70%, Missing); retina: 46.3636% (minimum 75%, Missing); salivary gland: 69.8630% (minimum 70%, Missing); skeletal muscle: 41.1290% (minimum 75%, Missing); small intestine: 71.8310% (minimum 75%, Missing); smooth muscle: 63.7500% (minimum 75%, Uncertain); spinal cord: 68.9189% (minimum 75%, Missing); stomach: 66.2338% (minimum 70%, Missing); thyroid gland: 59.3023% (minimum 65%, Missing); tongue: 40.4762% (minimum 70%, Missing)",-0.0569767,-0.295238,-0.398276,0,2,partial,9.4,7.5,3.5,"liver: 9.4 nTPM (vital, limit 1); tongue: 7.5 nTPM (protected, limit 3); skeletal muscle: 7.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); parathyroid gland: 4.6 nTPM (protected, limit 3); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ETFBKMT,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000139163,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 57.7039% (minimum 75%, Missing); amygdala: 67.7305% (minimum 75%, Missing); basal ganglia: 67.0175% (minimum 75%, Missing); bone marrow: 61.4148% (minimum 70%, Approved); cerebellum: 61.4148% (minimum 75%, Missing); cerebral cortex: 53.8028% (minimum 75%, Missing); choroid plexus: 72.9008% (minimum 75%, Missing); colon: 42.0705% (minimum 70%, Missing); duodenum: 45.6938% (minimum 75%, Missing); esophagus: 64.5270% (minimum 70%, Missing); heart muscle: 72.9008% (minimum 75%, Missing); hippocampal formation: 67.0175% (minimum 75%, Missing); hypothalamus: 56.8452% (minimum 75%, Missing); kidney: 51.7615% (minimum 75%, Missing); liver: 51.9022% (minimum 75%, Missing); lung: 61.0224% (minimum 75%, Missing); lymph node: 52.9086% (minimum 70%, Missing); midbrain: 65.8621% (minimum 75%, Missing); pancreas: 64.7458% (minimum 75%, Missing); parathyroid gland: 64.5270% (minimum 65%, Approved); pituitary gland: 58.9506% (minimum 75%, Missing); rectum: 56.1765% (minimum 70%, Missing); retina: 52.0436% (minimum 75%, Missing); salivary gland: 61.2179% (minimum 70%, Missing); skin: 56.1765% (minimum 65%, Missing); small intestine: 56.0117% (minimum 75%, Missing); spinal cord: 63.2450% (minimum 75%, Missing); spleen: 53.9548% (minimum 60%, Approved); stomach: 30.3175% (minimum 70%, Missing); thymus: 45.9135% (minimum 65%, Missing); thyroid gland: 57.5301% (minimum 65%, Missing); urinary bladder: 64.7458% (minimum 70%, Missing)",-0.190865,-0.396825,-0.293062,0,4,partial,22.7,43.9,22.5,"stomach: 43.9 nTPM (protected, limit 3); colon: 26.3 nTPM (protected, limit 3); duodenum: 22.7 nTPM (vital, limit 1); thymus: 22.5 nTPM (manageable, limit 5); kidney: 17.8 nTPM (vital, limit 1); liver: 17.7 nTPM (vital, limit 1); retina: 17.6 nTPM (vital, limit 1); lymph node: 17 nTPM (protected, limit 3); cerebral cortex: 16.4 nTPM (vital, limit 1); spleen: 16.3 nTPM (manageable, limit 10); small intestine: 15 nTPM (vital, limit 1); skin: 14.9 nTPM (manageable, limit 5); rectum: 14.9 nTPM (protected, limit 3); hypothalamus: 14.5 nTPM (vital, limit 1); thyroid gland: 14.1 nTPM (manageable, limit 5); adrenal gland: 14 nTPM (vital, limit 1); pituitary gland: 13.3 nTPM (vital, limit 1); lung: 12.2 nTPM (vital, limit 1); salivary gland: 12.1 nTPM (protected, limit 3); cerebellum: 12 nTPM (vital, limit 1); bone marrow: 12 nTPM (vital, limit 2); spinal cord: 11.1 nTPM (vital, limit 1); esophagus: 10.5 nTPM (protected, limit 3); parathyroid gland: 10.5 nTPM (protected, limit 4); pancreas: 10.4 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 3); midbrain: 9.9 nTPM (vital, limit 1); adipose tissue: 9.8 nTPM (manageable, limit 5); hippocampal formation: 9.4 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); amygdala: 9.1 nTPM (vital, limit 1); smooth muscle: 7.3 nTPM (vital, limit 2); heart muscle: 7.1 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ETNK1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000139304,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 45.6140% (minimum 65%, Missing); heart muscle: 70.2703% (minimum 75%, Missing); kidney: 27.3684% (minimum 75%, Missing); lung: 54.1667% (minimum 75%, Missing); thyroid gland: 48.1481% (minimum 65%, Missing); urinary bladder: 40.0000% (minimum 70%, Missing)",-0.19386,-0.3,-0.476316,0,80,unavailable,6.9,3.9,3.1,"kidney: 6.9 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 3); lung: 2.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PTPRQ,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000139350,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 60.2632% (minimum 75%, Missing); heart muscle: 72.0126% (minimum 75%, Missing); kidney: 72.6984% (minimum 75%, Missing); lung: 72.9299% (minimum 75%, Missing); lymph node: 60.4222% (minimum 70%, Missing); parathyroid gland: 61.3941% (minimum 70%, Missing); skeletal muscle: 38.4228% (minimum 75%, Missing); smooth muscle: 64.5070% (minimum 75%, Missing); spleen: 63.7883% (minimum 65%, Missing); thymus: 51.1161% (minimum 65%, Missing); tongue: 48.2105% (minimum 70%, Missing)",-0.138839,-0.217895,-0.365772,0,2,partial,36.7,24.6,21.9,"skeletal muscle: 36.7 nTPM (vital, limit 1); tongue: 24.6 nTPM (protected, limit 3); thymus: 21.9 nTPM (manageable, limit 5); bone marrow: 15.1 nTPM (vital, limit 1); lymph node: 15 nTPM (protected, limit 3); parathyroid gland: 14.4 nTPM (protected, limit 3); spleen: 13 nTPM (manageable, limit 5); smooth muscle: 12.6 nTPM (vital, limit 1); thyroid gland: 10.2 nTPM (manageable, limit 5); esophagus: 9.7 nTPM (protected, limit 3); rectum: 9.4 nTPM (protected, limit 3); urinary bladder: 9.2 nTPM (protected, limit 3); heart muscle: 8.9 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); kidney: 8.6 nTPM (vital, limit 1); lung: 8.5 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); colon: 8 nTPM (protected, limit 3); stomach: 7 nTPM (protected, limit 3); retina: 7 nTPM (vital, limit 1); pancreas: 6.9 nTPM (vital, limit 1); duodenum: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 3); liver: 6.1 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NEDD1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000139351,True,compatible,,True,True,True,,0.348759,0.3,0.248759,0,1,partial,0.7,0.5,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; lymph node; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SYCP3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000139445,True,compatible,,True,True,True,,0.323684,0.273684,0.182773,0,80,unavailable,0.8,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FOXN4,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000139496,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 69.5721% (minimum 70%, Approved); cerebellum: 73.0449% (minimum 75%, Missing); lung: 72.2039% (minimum 75%, Missing); lymph node: 68.9168% (minimum 70%, Missing); pituitary gland: 68.3801% (minimum 75%, Missing); retina: 63.3478% (minimum 75%, Missing); thymus: 62.9842% (minimum 65%, Missing); tongue: 66.1145% (minimum 70%, Missing)",-0.0201578,-0.0388554,-0.116522,0,7,partial,25.4,22.5,25.8,"thymus: 25.8 nTPM (manageable, limit 5); retina: 25.4 nTPM (vital, limit 1); tongue: 22.5 nTPM (protected, limit 3); pituitary gland: 20.3 nTPM (vital, limit 1); lymph node: 19.8 nTPM (protected, limit 3); bone marrow: 19.2 nTPM (vital, limit 2); skeletal muscle: 18.8 nTPM (vital, limit 2); thyroid gland: 18.3 nTPM (manageable, limit 5); urinary bladder: 17.9 nTPM (protected, limit 3); lung: 16.9 nTPM (vital, limit 1); cerebellum: 16.2 nTPM (vital, limit 1); cerebral cortex: 14 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); liver: 13.7 nTPM (vital, limit 1); heart muscle: 13.1 nTPM (vital, limit 1); adipose tissue: 12.7 nTPM (manageable, limit 10); hypothalamus: 12.6 nTPM (vital, limit 1); esophagus: 12.4 nTPM (protected, limit 3); rectum: 12.4 nTPM (protected, limit 3); smooth muscle: 12.3 nTPM (vital, limit 1); stomach: 11.8 nTPM (protected, limit 3); adrenal gland: 11.4 nTPM (vital, limit 2); spleen: 11.3 nTPM (manageable, limit 5); skin: 11.3 nTPM (manageable, limit 5); duodenum: 11.1 nTPM (vital, limit 1); basal ganglia: 11 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 3); pancreas: 10.5 nTPM (vital, limit 1); salivary gland: 10.4 nTPM (protected, limit 3); amygdala: 10.2 nTPM (vital, limit 1); midbrain: 9.9 nTPM (vital, limit 1); parathyroid gland: 9.7 nTPM (protected, limit 3); choroid plexus: 4.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NUP58,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000139537,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 65.6987% (minimum 75%, Missing)",0.285401,0.262766,-0.0930127,0,80,unavailable,18.9,1.4,2.5,"choroid plexus: 18.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC65,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000139549,True,compatible,,True,True,True,,0.302941,0.264286,0.19186,0,80,unavailable,1,0.6,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DHH,current_adaptive,True,False,True,False,10.1002/1878-0261.12900,Jamin 2021,False,True,True,True,True,gained,selectivity_revised
ENSG00000139618,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 35.7143% (minimum 75%, Missing); lymph node: 58.8235% (minimum 70%, Missing); thymus: 40.5405% (minimum 65%, Missing)",-0.244595,-0.111765,-0.392857,0,80,unavailable,5.4,2.1,4.4,"bone marrow: 5.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BRCA2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000139714,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 67.6923% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebral cortex: 64.7059% (minimum 75%, Missing); choroid plexus: 42.3077% (minimum 75%, Missing); hippocampal formation: 63.7681% (minimum 75%, Missing); hypothalamus: 68.7500% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing)",0.0596774,-0.0333333,-0.326923,0,80,unavailable,6,2.2,1.8,"choroid plexus: 6 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MORN3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000139719,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.5659% (minimum 65%, Missing); adrenal gland: 55.4054% (minimum 75%, Missing); amygdala: 59.4203% (minimum 75%, Missing); basal ganglia: 56.1644% (minimum 75%, Missing); bone marrow: 56.5517% (minimum 75%, Missing); cerebellum: 52.2293% (minimum 75%, Missing); cerebral cortex: 51.2500% (minimum 75%, Missing); choroid plexus: 58.9928% (minimum 75%, Missing); colon: 55.4054% (minimum 70%, Missing); duodenum: 62.1212% (minimum 75%, Missing); esophagus: 62.5954% (minimum 70%, Missing); heart muscle: 64.0625% (minimum 75%, Missing); hippocampal formation: 57.3427% (minimum 75%, Missing); hypothalamus: 56.1644% (minimum 75%, Missing); kidney: 65.6000% (minimum 75%, Missing); liver: 58.9928% (minimum 75%, Missing); lung: 61.6541% (minimum 75%, Missing); lymph node: 51.2500% (minimum 70%, Missing); midbrain: 57.7465% (minimum 75%, Missing); pancreas: 60.7407% (minimum 75%, Missing); parathyroid gland: 58.1560% (minimum 70%, Missing); pituitary gland: 47.6744% (minimum 75%, Missing); rectum: 60.7407% (minimum 70%, Missing); retina: 44.8087% (minimum 75%, Missing); salivary gland: 65.0794% (minimum 70%, Missing); skeletal muscle: 48.8095% (minimum 75%, Missing); skin: 55.0336% (minimum 65%, Missing); small intestine: 58.5714% (minimum 75%, Missing); smooth muscle: 56.9444% (minimum 75%, Missing); spinal cord: 56.9444% (minimum 75%, Missing); spleen: 54.6667% (minimum 65%, Missing); stomach: 60.2941% (minimum 70%, Missing); thymus: 46.8571% (minimum 65%, Missing); tongue: 58.5714% (minimum 70%, Missing); urinary bladder: 61.6541% (minimum 70%, Missing)",-0.181429,-0.1875,-0.301913,0,80,unavailable,10.1,7.8,9.3,"retina: 10.1 nTPM (vital, limit 1); thymus: 9.3 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 3); cerebral cortex: 7.8 nTPM (vital, limit 1); cerebellum: 7.5 nTPM (vital, limit 1); spleen: 6.8 nTPM (manageable, limit 5); skin: 6.7 nTPM (manageable, limit 5); colon: 6.6 nTPM (protected, limit 3); adrenal gland: 6.6 nTPM (vital, limit 1); hypothalamus: 6.4 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); spinal cord: 6.2 nTPM (vital, limit 1); smooth muscle: 6.2 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 3); small intestine: 5.8 nTPM (vital, limit 1); tongue: 5.8 nTPM (protected, limit 3); liver: 5.7 nTPM (vital, limit 1); choroid plexus: 5.7 nTPM (vital, limit 1); amygdala: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); pancreas: 5.3 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 3); lung: 5.1 nTPM (vital, limit 1); urinary bladder: 5.1 nTPM (protected, limit 3); duodenum: 5 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 3); heart muscle: 4.6 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 3); kidney: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,VPS33A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000139734,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 72.3320% (minimum 75%, Missing)",0.125424,0.18835,-0.0266798,0,80,unavailable,7,2.3,5.3,"bone marrow: 7 nTPM (vital, limit 1); thymus: 5.3 nTPM (manageable, limit 5); smooth muscle: 2.5 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DIAPH3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000139797,True,compatible,,True,True,True,,0.35,0.3,0.245643,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RNF113B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000139800,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 69.2308% (minimum 75%, Missing); cerebellum: 11.7647% (minimum 75%, Missing); cerebral cortex: 61.0169% (minimum 75%, Missing); choroid plexus: 40.4494% (minimum 75%, Missing); hippocampal formation: 67.9245% (minimum 75%, Missing); retina: 52.1739% (minimum 75%, Missing)",0.35,0.3,-0.632353,0,80,unavailable,27,0,0,"cerebellum: 27 nTPM (vital, limit 1); choroid plexus: 5.3 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZIC5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000139890,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 38.5246% (minimum 75%, Missing); bone marrow: 32.6389% (minimum 75%, Missing); cerebellum: 61.8421% (minimum 75%, Missing); hypothalamus: 72.3077% (minimum 75%, Missing); kidney: 74.6032% (minimum 75%, Missing); lung: 68.1159% (minimum 75%, Missing); pituitary gland: 45.6311% (minimum 75%, Missing); small intestine: 70.1493% (minimum 75%, Missing); spleen: 45.1923% (minimum 65%, Missing)",-0.198077,0.0833333,-0.423611,0,80,unavailable,9.7,1.3,5.7,"bone marrow: 9.7 nTPM (vital, limit 1); basal ganglia: 7.5 nTPM (vital, limit 1); spleen: 5.7 nTPM (manageable, limit 5); pituitary gland: 5.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,REM2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000139915,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 51.3889% (minimum 75%, Uncertain); hypothalamus: 74.0000% (minimum 75%, Missing); retina: 46.2500% (minimum 75%, Missing); spinal cord: 68.5185% (minimum 75%, Missing)",0.275,0.248718,-0.2875,0,4,partial,4.3,0.2,0.3,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,51,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MDGA2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000140006,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.2047% (minimum 65%, Uncertain); adrenal gland: 58.0882% (minimum 75%, Missing); amygdala: 65.2893% (minimum 75%, Missing); basal ganglia: 64.7541% (minimum 75%, Missing); bone marrow: 72.4771% (minimum 75%, Uncertain); cerebellum: 58.0882% (minimum 75%, Uncertain); cerebral cortex: 60.7692% (minimum 75%, Missing); choroid plexus: 74.5283% (minimum 75%, Missing); colon: 57.2464% (minimum 70%, Missing); duodenum: 61.7188% (minimum 75%, Missing); esophagus: 60.7692% (minimum 70%, Uncertain); heart muscle: 65.2893% (minimum 75%, Uncertain); hippocampal formation: 65.8333% (minimum 75%, Missing); hypothalamus: 65.8333% (minimum 75%, Missing); kidney: 48.1707% (minimum 75%, Missing); liver: 48.1707% (minimum 75%, Missing); lung: 59.8485% (minimum 75%, Missing); lymph node: 41.7989% (minimum 70%, Missing); midbrain: 68.6957% (minimum 75%, Missing); pancreas: 58.0882% (minimum 75%, Missing); parathyroid gland: 52.3179% (minimum 70%, Missing); pituitary gland: 72.4771% (minimum 75%, Missing); rectum: 54.8611% (minimum 70%, Missing); retina: 41.7989% (minimum 75%, Missing); salivary gland: 66.9492% (minimum 70%, Missing); skeletal muscle: 58.5185% (minimum 75%, Uncertain); skin: 56.8345% (minimum 65%, Uncertain); small intestine: 66.9492% (minimum 75%, Missing); smooth muscle: 60.7692% (minimum 75%, Uncertain); spinal cord: 64.2276% (minimum 75%, Missing); spleen: 48.4663% (minimum 65%, Uncertain); stomach: 59.8485% (minimum 70%, Missing); thymus: 44.6328% (minimum 65%, Missing); thyroid gland: 47.0238% (minimum 65%, Missing); tongue: 53.0201% (minimum 70%, Missing); urinary bladder: 55.2448% (minimum 70%, Missing)",-0.203672,-0.282011,-0.332011,0,4,partial,11,11,9.8,"retina: 11 nTPM (vital, limit 1); lymph node: 11 nTPM (protected, limit 3); thymus: 9.8 nTPM (manageable, limit 5); thyroid gland: 8.9 nTPM (manageable, limit 5); liver: 8.5 nTPM (vital, limit 1); kidney: 8.5 nTPM (vital, limit 1); spleen: 8.4 nTPM (manageable, limit 5); parathyroid gland: 7.2 nTPM (protected, limit 3); tongue: 7 nTPM (protected, limit 3); rectum: 6.5 nTPM (protected, limit 3); urinary bladder: 6.4 nTPM (protected, limit 3); skin: 6 nTPM (manageable, limit 5); colon: 5.9 nTPM (protected, limit 3); pancreas: 5.7 nTPM (vital, limit 1); adrenal gland: 5.7 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 3); esophagus: 5.1 nTPM (protected, limit 3); smooth muscle: 5.1 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); small intestine: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,WDR89,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000140009,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 48.2456% (minimum 75%, Missing)",0.0462025,0.0333333,-0.267544,0,2,partial,5.9,2,2.4,"adrenal gland: 5.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",adrenal gland / cells in zona glomerulosa: Medium (Enhanced); adrenal gland / glandular cells: Low (Enhanced); adrenal gland / medullary cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ESR2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000140015,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Missing); adrenal gland: 23.0769% (minimum 75%, Missing); amygdala: 33.3333% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); cerebral cortex: 11.5385% (minimum 75%, Missing); choroid plexus: 37.5000% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 23.0769% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); retina: 6.5217% (minimum 75%, Missing); spinal cord: 60.0000% (minimum 75%, Missing)",-0.05,0.3,-0.684783,0,80,unavailable,4.3,0,0.2,"retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KCNH5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000140025,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.17448,0.118807,0.0744804,0,80,unavailable,7.6,7.9,7.6,"parathyroid gland: 7.9 nTPM (protected, limit 3); thyroid gland: 7.6 nTPM (manageable, limit 5); amygdala: 7.6 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); spinal cord: 6.6 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); retina: 6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); choroid plexus: 5.5 nTPM (vital, limit 1); rectum: 5.3 nTPM (protected, limit 3); colon: 5.2 nTPM (protected, limit 3); hypothalamus: 5 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); pancreas: 4.7 nTPM (vital, limit 1); salivary gland: 4.6 nTPM (protected, limit 3); urinary bladder: 4.5 nTPM (protected, limit 3); stomach: 4.4 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 3); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EFCAB11,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000140043,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 58.7413% (minimum 75%, Missing); amygdala: 55.6291% (minimum 75%, Missing); basal ganglia: 55.2632% (minimum 75%, Missing); cerebellum: 74.3363% (minimum 75%, Missing); cerebral cortex: 57.3379% (minimum 75%, Missing); choroid plexus: 50.9091% (minimum 75%, Missing); duodenum: 58.7413% (minimum 75%, Missing); heart muscle: 38.8889% (minimum 75%, Missing); hippocampal formation: 59.7865% (minimum 75%, Missing); hypothalamus: 60.2151% (minimum 75%, Missing); kidney: 48.0000% (minimum 75%, Missing); liver: 47.5921% (minimum 75%, Missing); midbrain: 53.5032% (minimum 75%, Missing); parathyroid gland: 62.2222% (minimum 70%, Missing); pituitary gland: 69.4215% (minimum 75%, Missing); retina: 61.5385% (minimum 75%, Missing); skeletal muscle: 34.6392% (minimum 75%, Missing); small intestine: 65.8824% (minimum 75%, Missing); spinal cord: 57.5342% (minimum 75%, Missing); thyroid gland: 57.7320% (minimum 65%, Missing); tongue: 35.0731% (minimum 70%, Missing)",-0.0726804,-0.349269,-0.403608,0,4,partial,31.7,31.1,12.3,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.1 nTPM (protected, limit 3); heart muscle: 26.4 nTPM (vital, limit 1); liver: 18.5 nTPM (vital, limit 1); kidney: 18.2 nTPM (vital, limit 1); choroid plexus: 16.2 nTPM (vital, limit 1); midbrain: 14.6 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); amygdala: 13.4 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); thyroid gland: 12.3 nTPM (manageable, limit 5); adrenal gland: 11.8 nTPM (vital, limit 1); duodenum: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); hypothalamus: 11.1 nTPM (vital, limit 1); retina: 10.5 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 3); small intestine: 8.7 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); colon: 7 nTPM (protected, limit 3); skin: 6.8 nTPM (manageable, limit 5); salivary gland: 6.6 nTPM (protected, limit 3); stomach: 6.1 nTPM (protected, limit 3); cerebellum: 5.8 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 3); lung: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 4); urinary bladder: 4.1 nTPM (protected, limit 3); smooth muscle: 2.5 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PTGR2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000140057,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 57.0388% (minimum 75%, Missing)",0.23015,0.200383,-0.179612,0,13,partial,17.7,6.7,5.4,"choroid plexus: 17.7 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); duodenum / paneth cells: High (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); small intestine / paneth cells: High (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AK7,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000140067,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 70.0665% (minimum 75%, Missing)",0.35,0.3,-0.0493348,0,2,partial,13.5,0,1.1,"amygdala: 13.5 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 6); basal ganglia: 9.9 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); midbrain: 8.1 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM181A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000140090,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 25.6410% (minimum 75%, Missing); basal ganglia: 20.4082% (minimum 75%, Missing); bone marrow: 22.2222% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing); cerebral cortex: 17.5439% (minimum 75%, Missing); choroid plexus: 2.1834% (minimum 75%, Missing); hippocampal formation: 35.7143% (minimum 75%, Missing); hypothalamus: 32.2581% (minimum 75%, Missing); lung: 58.8235% (minimum 75%, Missing); lymph node: 47.6190% (minimum 70%, Missing); midbrain: 16.3934% (minimum 75%, Missing); pituitary gland: 43.4783% (minimum 75%, Missing); retina: 7.6923% (minimum 75%, Missing); skeletal muscle: 55.5556% (minimum 75%, Missing); smooth muscle: 71.4286% (minimum 75%, Missing); spinal cord: 30.3030% (minimum 75%, Missing); spleen: 27.7778% (minimum 65%, Missing); tongue: 50.0000% (minimum 70%, Missing)",-0.372222,-0.22381,-0.728166,0,80,unavailable,44.8,1.1,2.6,"choroid plexus: 44.8 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC24A4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000140199,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 48.6434% (minimum 75%, Missing); esophagus: 57.8341% (minimum 70%, Uncertain); kidney: 62.1287% (minimum 75%, Uncertain); lung: 74.0413% (minimum 75%, Missing); retina: 45.4710% (minimum 75%, Missing); skeletal muscle: 71.1048% (minimum 75%, Uncertain); small intestine: 74.0413% (minimum 75%, Missing); spinal cord: 74.7024% (minimum 75%, Missing); thymus: 62.4378% (minimum 65%, Missing)",-0.0256219,-0.121659,-0.29529,0,3,partial,30.1,18.3,15.1,"retina: 30.1 nTPM (vital, limit 1); bone marrow: 26.5 nTPM (vital, limit 1); esophagus: 18.3 nTPM (protected, limit 3); kidney: 15.3 nTPM (vital, limit 1); thymus: 15.1 nTPM (manageable, limit 5); spleen: 12.5 nTPM (manageable, limit 5); tongue: 10.5 nTPM (protected, limit 3); skeletal muscle: 10.2 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 3); small intestine: 8.8 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); thyroid gland: 8.7 nTPM (manageable, limit 5); spinal cord: 8.5 nTPM (vital, limit 1); cerebral cortex: 8.1 nTPM (vital, limit 1); urinary bladder: 8 nTPM (protected, limit 3); cerebellum: 7.7 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); heart muscle: 7.1 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); midbrain: 7 nTPM (vital, limit 1); basal ganglia: 6.9 nTPM (vital, limit 1); stomach: 6.5 nTPM (protected, limit 3); hippocampal formation: 6.5 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); adipose tissue: 6.2 nTPM (manageable, limit 5); salivary gland: 6.2 nTPM (protected, limit 3); amygdala: 6 nTPM (vital, limit 1); rectum: 5.9 nTPM (protected, limit 3); pituitary gland: 5.5 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 3); smooth muscle: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC12A6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000140470,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.0526% (minimum 75%, Missing); amygdala: 57.4468% (minimum 75%, Missing); basal ganglia: 60.0000% (minimum 75%, Missing); cerebral cortex: 62.7907% (minimum 75%, Missing); choroid plexus: 56.2500% (minimum 75%, Missing); esophagus: 57.4468% (minimum 70%, Missing); heart muscle: 69.2308% (minimum 75%, Missing); hippocampal formation: 65.8537% (minimum 75%, Missing); kidney: 72.9730% (minimum 75%, Missing); liver: 26.7327% (minimum 75%, Missing); lung: 65.8537% (minimum 75%, Missing); pancreas: 36.0000% (minimum 75%, Missing); pituitary gland: 69.2308% (minimum 75%, Missing); salivary gland: 51.9231% (minimum 70%, Missing); skeletal muscle: 33.3333% (minimum 75%, Missing); skin: 56.2500% (minimum 65%, Missing); small intestine: 71.0526% (minimum 75%, Missing); thymus: 20.6107% (minimum 65%, Missing); urinary bladder: 62.7907% (minimum 70%, Missing)",-0.443893,-0.180769,-0.482673,0,80,unavailable,7.4,2.5,10.4,"thymus: 10.4 nTPM (manageable, limit 5); liver: 7.4 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ADAMTS17,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000140478,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.7,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GOLGA6D,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,True,True,True,True,gained,selectivity_revised
ENSG00000140527,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 62.2222% (minimum 75%, Missing)",0.218217,0.257265,-0.127778,0,80,unavailable,6.8,0.5,1.7,"choroid plexus: 6.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,WDR93,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000140534,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 29.1667% (minimum 75%, Missing); colon: 63.6364% (minimum 70%, Missing); duodenum: 58.3333% (minimum 75%, Missing); esophagus: 25.4545% (minimum 70%, Missing); lymph node: 50.0000% (minimum 70%, Missing); rectum: 56.0000% (minimum 70%, Missing); small intestine: 60.8696% (minimum 75%, Missing); thymus: 25.9259% (minimum 65%, Missing)",-0.390741,-0.445455,-0.458333,0,80,unavailable,3.4,4.1,4,"esophagus: 4.1 nTPM (protected, limit 3); bone marrow: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TICRR,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000140623,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.21875,0,80,unavailable,3.1,0,0,"cerebellum: 3.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SEPTIN12,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000140798,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 66.6667% (minimum 75%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing)",0.35,0.3,-0.0833333,0,80,unavailable,1.4,0,0,"cerebral cortex: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ABCC12,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000140932,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347786,0.299683,0.248102,0,80,unavailable,1.2,0.2,1.4,"cerebellum: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CMTM2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000140955,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342114,0.29683,0.217692,0,10,partial,2.1,0.7,3.6,"basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ADAD2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000140993,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.1343% (minimum 75%, Missing); amygdala: 68.0556% (minimum 75%, Missing); basal ganglia: 68.0556% (minimum 75%, Missing); cerebellum: 60.4938% (minimum 75%, Missing); cerebral cortex: 67.1233% (minimum 75%, Uncertain); choroid plexus: 50.7772% (minimum 75%, Missing); colon: 67.1233% (minimum 70%, Missing); heart muscle: 65.3333% (minimum 75%, Missing); hippocampal formation: 68.0556% (minimum 75%, Missing); hypothalamus: 65.3333% (minimum 75%, Missing); kidney: 62.8205% (minimum 75%, Missing); midbrain: 68.5315% (minimum 75%, Missing); parathyroid gland: 60.8696% (minimum 70%, Missing); pituitary gland: 55.3672% (minimum 75%, Missing); retina: 55.0562% (minimum 75%, Missing); skeletal muscle: 71.0145% (minimum 75%, Missing); smooth muscle: 74.8092% (minimum 75%, Missing); spinal cord: 68.0556% (minimum 75%, Missing); thyroid gland: 58.3333% (minimum 65%, Missing); tongue: 66.2162% (minimum 70%, Missing)",-0.0666667,-0.0913043,-0.242228,0,3,partial,9.5,6.3,7,"choroid plexus: 9.5 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); pituitary gland: 7.9 nTPM (vital, limit 1); thyroid gland: 7 nTPM (manageable, limit 5); cerebellum: 6.4 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 3); kidney: 5.8 nTPM (vital, limit 1); heart muscle: 5.2 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 3); colon: 4.8 nTPM (protected, limit 3); cerebral cortex: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); amygdala: 4.6 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); midbrain: 4.5 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); lymph node: 4 nTPM (protected, limit 3); urinary bladder: 3.9 nTPM (protected, limit 3); adrenal gland: 3.6 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); duodenum: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TIGD7,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000141096,True,compatible,,True,True,True,,0.347817,0.287041,0.245643,0,3,partial,1.7,0.6,2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DPEP3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,False,unchanged,
ENSG00000141194,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 28.5714% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 66.6667% (minimum 75%, Missing); lymph node: 33.3333% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing); spleen: 40.0000% (minimum 65%, Missing); stomach: 66.6667% (minimum 70%, Missing); urinary bladder: 66.6667% (minimum 70%, Missing)",-0.25,-0.366667,-0.464286,0,80,unavailable,0.5,0.4,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR4D1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000141200,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0,0,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KIF2B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000141219,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 74.7573% (minimum 75%, Missing); heart muscle: 71.9626% (minimum 75%, Missing); retina: 63.3224% (minimum 75%, Missing); skeletal muscle: 62.7036% (minimum 75%, Missing); tongue: 65.0338% (minimum 70%, Missing)",0.042446,-0.0496622,-0.122964,0,1,partial,22.9,20.7,17.1,"skeletal muscle: 22.9 nTPM (vital, limit 1); retina: 22.3 nTPM (vital, limit 1); tongue: 20.7 nTPM (protected, limit 3); thymus: 17.1 nTPM (manageable, limit 5); parathyroid gland: 15.8 nTPM (protected, limit 3); thyroid gland: 15.4 nTPM (manageable, limit 5); heart muscle: 15 nTPM (vital, limit 1); lymph node: 13.2 nTPM (protected, limit 3); cerebellum: 13 nTPM (vital, limit 1); kidney: 12.1 nTPM (vital, limit 1); smooth muscle: 12.1 nTPM (vital, limit 1); colon: 11.2 nTPM (protected, limit 3); spleen: 10.4 nTPM (manageable, limit 5); salivary gland: 10.3 nTPM (protected, limit 3); pituitary gland: 10.3 nTPM (vital, limit 1); duodenum: 10.1 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 3); cerebral cortex: 9.8 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 3); adrenal gland: 9.6 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 1); urinary bladder: 8.8 nTPM (protected, limit 3); midbrain: 8.7 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); esophagus: 8.3 nTPM (protected, limit 3); amygdala: 8.3 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); spinal cord: 8.2 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); hippocampal formation: 7.9 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MTNAP1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000141255,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345544,0.288058,0.2451,0,80,unavailable,1.1,2.7,1,"midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA22,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000141316,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.235437,0,6,partial,20.3,0.2,0.3,"pancreas: 20.3 nTPM (vital, limit 6); choroid plexus: 1.8 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPACA3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000141371,True,compatible,,True,True,True,,0.34924,0.3,0.248481,0,4,partial,0.6,0.1,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CHCT1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000141384,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.2308% (minimum 75%, Missing); bone marrow: 61.6438% (minimum 75%, Uncertain); lymph node: 60.0000% (minimum 70%, Missing)",0.00217391,-0.1,-0.133562,0,0,routine_complete,2.8,3,2.4,"bone marrow: 2.8 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TAF4B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000141404,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 48.9552% (minimum 75%, Missing); basal ganglia: 20.9987% (minimum 75%, Missing); cerebral cortex: 50.9317% (minimum 60%, Enhanced); hippocampal formation: 59.2058% (minimum 75%, Missing); hypothalamus: 57.1429% (minimum 75%, Missing); midbrain: 63.5659% (minimum 75%, Missing); pituitary gland: 50.9317% (minimum 75%, Missing); skeletal muscle: 43.8503% (minimum 60%, Enhanced); tongue: 56.5517% (minimum 70%, Missing); urinary bladder: 56.1644% (minimum 70%, Missing)",0.146117,-0.138356,-0.540013,0,11,partial,61.7,12.8,7.6,"basal ganglia: 61.7 nTPM (vital, limit 1); skeletal muscle: 21 nTPM (vital, limit 6); amygdala: 17.1 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 6); pituitary gland: 15.8 nTPM (vital, limit 1); urinary bladder: 12.8 nTPM (protected, limit 3); tongue: 12.6 nTPM (protected, limit 3); hypothalamus: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); midbrain: 9.4 nTPM (vital, limit 1); smooth muscle: 7.2 nTPM (vital, limit 6); colon: 6.9 nTPM (protected, limit 3); choroid plexus: 5 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); spinal cord: 4.4 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 3); small intestine: 3.1 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); caudate / neuronal cells: Low (Enhanced); caudate / synapses: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),80,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GNAL,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000141425,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 71.9590% (minimum 75%, Missing); cerebellum: 73.8017% (minimum 75%, Missing); cerebral cortex: 70.9596% (minimum 75%, Missing); hippocampal formation: 72.8451% (minimum 75%, Missing); hypothalamus: 73.9474% (minimum 75%, Missing); midbrain: 73.9961% (minimum 75%, Missing); retina: 73.6566% (minimum 75%, Missing); skeletal muscle: 68.0387% (minimum 75%, Missing); spinal cord: 72.4694% (minimum 75%, Missing)",0.133275,0.0154679,-0.0696126,0,12,partial,52.8,44.7,31.1,"skeletal muscle: 52.8 nTPM (vital, limit 1); cerebral cortex: 46 nTPM (vital, limit 1); tongue: 44.7 nTPM (protected, limit 3); amygdala: 43.8 nTPM (vital, limit 1); spinal cord: 42.7 nTPM (vital, limit 1); hippocampal formation: 41.9 nTPM (vital, limit 1); retina: 40.2 nTPM (vital, limit 1); cerebellum: 39.9 nTPM (vital, limit 1); hypothalamus: 39.6 nTPM (vital, limit 1); midbrain: 39.5 nTPM (vital, limit 1); basal ganglia: 35.8 nTPM (vital, limit 1); adrenal gland: 33.7 nTPM (vital, limit 1); thyroid gland: 31.1 nTPM (manageable, limit 5); colon: 28.6 nTPM (protected, limit 3); heart muscle: 28.1 nTPM (vital, limit 1); salivary gland: 27.4 nTPM (protected, limit 3); pituitary gland: 27.1 nTPM (vital, limit 1); urinary bladder: 26.7 nTPM (protected, limit 3); kidney: 25.8 nTPM (vital, limit 1); parathyroid gland: 25.2 nTPM (protected, limit 3); esophagus: 22.8 nTPM (protected, limit 3); pancreas: 22.7 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); spleen: 21.7 nTPM (manageable, limit 5); liver: 21.1 nTPM (vital, limit 1); stomach: 20.7 nTPM (protected, limit 3); smooth muscle: 20.6 nTPM (vital, limit 1); skin: 20.2 nTPM (manageable, limit 5); rectum: 19.9 nTPM (protected, limit 3); choroid plexus: 19.4 nTPM (vital, limit 1); thymus: 19.4 nTPM (manageable, limit 5); lymph node: 19 nTPM (protected, limit 3); lung: 18.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); small intestine: 18.4 nTPM (vital, limit 1); bone marrow: 11.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Low (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endocrine cells: High (Supported); colon / endothelial cells: Low (Supported); colon / enterocytes: High (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / glands of Brunner: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: Medium (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RPRD1A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000141431,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 68.0000% (minimum 75%, Missing); cerebral cortex: 53.1250% (minimum 75%, Missing); hippocampal formation: 70.8333% (minimum 75%, Missing); hypothalamus: 65.3846% (minimum 75%, Missing); kidney: 73.9130% (minimum 75%, Missing); midbrain: 73.9130% (minimum 75%, Missing); pituitary gland: 70.8333% (minimum 75%, Missing); spinal cord: 73.9130% (minimum 75%, Missing); stomach: 68.0000% (minimum 70%, Missing)",0.00384615,-0.02,-0.21875,0,80,unavailable,1.5,0.8,0.9,"cerebral cortex: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ASXL3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000141437,True,compatible,,True,True,True,,0.330583,0.3,0.193925,0,80,unavailable,0.6,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC25A52,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,True,True,True,True,gained,selectivity_revised
ENSG00000141497,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.188415,0.138415,0.109375,0,80,unavailable,4.5,5.3,5.3,"spleen: 5.3 nTPM (manageable, limit 5); parathyroid gland: 5.3 nTPM (protected, limit 3); lung: 4.5 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZMYND15,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000141505,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 54.7974% (minimum 60%, Enhanced); liver: 2.3550% (minimum 75%, Missing)",0.206667,0.240769,-0.72645,0,5,partial,1065.6,6.8,5.6,"liver: 1065.6 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 6); cerebral cortex: 14.6 nTPM (vital, limit 6); hypothalamus: 7 nTPM (vital, limit 1); amygdala: 6.7 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); choroid plexus: 4.4 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1)",liver / hepatocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ASGR1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000141576,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 39.7653% (minimum 75%, Missing); basal ganglia: 42.1271% (minimum 75%, Missing); cerebellum: 56.1694% (minimum 75%, Missing); cerebral cortex: 28.9100% (minimum 75%, Missing); hippocampal formation: 33.5903% (minimum 75%, Missing); hypothalamus: 47.2136% (minimum 75%, Missing); midbrain: 42.7171% (minimum 75%, Missing); parathyroid gland: 68.3857% (minimum 70%, Missing); retina: 34.7777% (minimum 75%, Missing); skeletal muscle: 29.9902% (minimum 75%, Missing); spinal cord: 53.1359% (minimum 75%, Missing); tongue: 42.0690% (minimum 70%, Missing)",0.0495413,-0.27931,-0.4609,0,80,unavailable,75,42,13.1,"cerebral cortex: 75 nTPM (vital, limit 1); skeletal muscle: 71.2 nTPM (vital, limit 1); hippocampal formation: 60.3 nTPM (vital, limit 1); retina: 57.2 nTPM (vital, limit 1); amygdala: 46.2 nTPM (vital, limit 1); tongue: 42 nTPM (protected, limit 3); basal ganglia: 41.9 nTPM (vital, limit 1); midbrain: 40.9 nTPM (vital, limit 1); hypothalamus: 34.1 nTPM (vital, limit 1); spinal cord: 26.9 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 3); adipose tissue: 13.1 nTPM (manageable, limit 5); small intestine: 10.1 nTPM (vital, limit 1); choroid plexus: 9.8 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 3); duodenum: 9.3 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); heart muscle: 6.2 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); lymph node: 5 nTPM (protected, limit 3); stomach: 3.7 nTPM (protected, limit 3); pancreas: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RNF157,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000141644,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 68.9766% (minimum 75%, Missing); bone marrow: 66.1004% (minimum 75%, Missing); cerebellum: 70.2215% (minimum 75%, Missing); cerebral cortex: 71.3928% (minimum 75%, Missing); esophagus: 69.1997% (minimum 70%, Missing); heart muscle: 71.2739% (minimum 75%, Missing); kidney: 73.0375% (minimum 75%, Missing); lung: 74.6946% (minimum 75%, Missing); pancreas: 71.8724% (minimum 75%, Missing); pituitary gland: 67.2956% (minimum 75%, Missing); skeletal muscle: 63.5015% (minimum 75%, Missing); small intestine: 72.3584% (minimum 75%, Missing)",0.0203211,-0.00800323,-0.114985,0,5,partial,49.2,38.1,42.1,"skeletal muscle: 49.2 nTPM (vital, limit 1); bone marrow: 43.9 nTPM (vital, limit 1); skin: 42.1 nTPM (manageable, limit 5); pituitary gland: 41.6 nTPM (vital, limit 1); spleen: 40 nTPM (manageable, limit 5); adrenal gland: 38.5 nTPM (vital, limit 1); esophagus: 38.1 nTPM (protected, limit 3); cerebellum: 36.3 nTPM (vital, limit 1); liver: 34.8 nTPM (vital, limit 2); colon: 34.5 nTPM (protected, limit 3); heart muscle: 34.5 nTPM (vital, limit 1); cerebral cortex: 34.3 nTPM (vital, limit 1); thyroid gland: 34.3 nTPM (manageable, limit 5); urinary bladder: 34.2 nTPM (protected, limit 3); pancreas: 33.5 nTPM (vital, limit 1); small intestine: 32.7 nTPM (vital, limit 1); stomach: 32.6 nTPM (protected, limit 3); kidney: 31.6 nTPM (vital, limit 1); parathyroid gland: 31.5 nTPM (protected, limit 3); lymph node: 29.9 nTPM (protected, limit 3); salivary gland: 29.6 nTPM (protected, limit 3); thymus: 29.2 nTPM (manageable, limit 5); lung: 29 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 3); adipose tissue: 27.6 nTPM (manageable, limit 10); basal ganglia: 26.1 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.9 nTPM (vital, limit 1); retina: 23.4 nTPM (vital, limit 1); hypothalamus: 22.8 nTPM (vital, limit 1); spinal cord: 21.4 nTPM (vital, limit 1); choroid plexus: 21.2 nTPM (vital, limit 1); midbrain: 21.1 nTPM (vital, limit 1); smooth muscle: 20.3 nTPM (vital, limit 2); rectum: 17.4 nTPM (protected, limit 3)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MBD1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000141665,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 70.4082% (minimum 75%, Missing); retina: 67.6471% (minimum 75%, Missing)",0.27,0.22,-0.0735294,0,80,unavailable,3.3,0.6,0.6,"retina: 3.3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FBXO15,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000141946,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 75.0000% (minimum 75%, Missing); skeletal muscle: 60.0000% (minimum 75%, Missing)",0.1,0.3,-0.15,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZIM3,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000141977,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 36.8421% (minimum 75%, Missing)",0.225,0.175,-0.381579,0,80,unavailable,1.2,0.1,0.1,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CIB3,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000142025,True,compatible,,True,True,True,,0.347487,0.294987,0.2425,0,3,partial,0.3,0.2,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DMRTC2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000142149,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 61.6438% (minimum 75%, Missing); colon: 56.2500% (minimum 70%, Missing); kidney: 55.5556% (minimum 75%, Missing); pancreas: 32.1429% (minimum 75%, Missing); rectum: 55.5556% (minimum 70%, Missing); retina: 60.8108% (minimum 75%, Missing); skin: 60.8108% (minimum 65%, Missing); small intestine: 63.3803% (minimum 75%, Missing); smooth muscle: 66.1765% (minimum 75%, Missing)",-0.0418919,-0.144444,-0.428571,0,2,partial,9.5,3.6,2.9,"pancreas: 9.5 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); colon: 3.5 nTPM (protected, limit 3); retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HUNK,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000142511,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 2.9361% (minimum 70%, Missing)",0.35,-0.670639,0.25,0,80,unavailable,0,56.2,0,"parathyroid gland: 56.2 nTPM (protected, limit 3)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GPR32,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000142513,True,compatible,,True,True,True,,0.1,0.272973,0.128049,0,80,unavailable,0.5,0.1,1.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ACP4,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000142530,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.321317,0.267532,0.142216,0,80,unavailable,9,2.5,2.2,"basal ganglia: 9 nTPM (vital, limit 1); midbrain: 8.9 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); cerebellum: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GARIN5A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000142538,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebellum: 16.6667% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing)",0.35,0.3,-0.583333,0,80,unavailable,1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,PTH2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000142621,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 59.5238% (minimum 75%, Missing)",0.343377,0.243396,-0.154762,0,8,partial,10.2,2.2,1.2,"choroid plexus: 10.2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FHAD1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000142684,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.2644% (minimum 65%, Missing); adrenal gland: 50.2423% (minimum 75%, Missing); amygdala: 53.8062% (minimum 75%, Missing); basal ganglia: 55.0442% (minimum 75%, Missing); bone marrow: 60.7422% (minimum 75%, Missing); cerebellum: 68.8053% (minimum 75%, Missing); cerebral cortex: 54.6573% (minimum 75%, Missing); choroid plexus: 43.1345% (minimum 75%, Missing); colon: 57.5926% (minimum 70%, Missing); duodenum: 71.1670% (minimum 75%, Missing); esophagus: 49.6013% (minimum 70%, Missing); heart muscle: 45.8702% (minimum 75%, Missing); hippocampal formation: 55.8348% (minimum 75%, Missing); hypothalamus: 52.4452% (minimum 75%, Missing); kidney: 44.3020% (minimum 75%, Missing); liver: 33.2976% (minimum 75%, Missing); lung: 59.5785% (minimum 75%, Missing); midbrain: 52.0938% (minimum 75%, Missing); pancreas: 34.2511% (minimum 75%, Missing); parathyroid gland: 66.3113% (minimum 70%, Missing); pituitary gland: 55.4367% (minimum 75%, Missing); salivary gland: 56.9597% (minimum 70%, Missing); skeletal muscle: 24.1460% (minimum 75%, Missing); skin: 49.7600% (minimum 65%, Missing); small intestine: 60.2713% (minimum 75%, Missing); spinal cord: 60.9804% (minimum 75%, Missing); spleen: 53.0717% (minimum 65%, Missing); stomach: 45.0725% (minimum 70%, Missing); thyroid gland: 53.3448% (minimum 65%, Missing); tongue: 59.6929% (minimum 70%, Missing); urinary bladder: 55.7348% (minimum 70%, Missing)",-0.177356,-0.249275,-0.50854,0,5,partial,97.7,37.9,34.7,"skeletal muscle: 97.7 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); pancreas: 59.7 nTPM (vital, limit 1); choroid plexus: 41 nTPM (vital, limit 1); kidney: 39.1 nTPM (vital, limit 1); stomach: 37.9 nTPM (protected, limit 3); heart muscle: 36.7 nTPM (vital, limit 1); adipose tissue: 34.7 nTPM (manageable, limit 5); esophagus: 31.6 nTPM (protected, limit 3); skin: 31.4 nTPM (manageable, limit 5); adrenal gland: 30.8 nTPM (vital, limit 1); midbrain: 28.6 nTPM (vital, limit 1); hypothalamus: 28.2 nTPM (vital, limit 1); spleen: 27.5 nTPM (manageable, limit 5); thyroid gland: 27.2 nTPM (manageable, limit 5); amygdala: 26.7 nTPM (vital, limit 1); cerebral cortex: 25.8 nTPM (vital, limit 1); basal ganglia: 25.4 nTPM (vital, limit 1); pituitary gland: 25 nTPM (vital, limit 1); urinary bladder: 24.7 nTPM (protected, limit 3); hippocampal formation: 24.6 nTPM (vital, limit 1); salivary gland: 23.5 nTPM (protected, limit 3); colon: 22.9 nTPM (protected, limit 3); lung: 21.1 nTPM (vital, limit 1); tongue: 21 nTPM (protected, limit 3); small intestine: 20.5 nTPM (vital, limit 1); bone marrow: 20.1 nTPM (vital, limit 1); spinal cord: 19.9 nTPM (vital, limit 1); parathyroid gland: 15.8 nTPM (protected, limit 3); cerebellum: 14.1 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); lymph node: 9.8 nTPM (protected, limit 3); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); retina: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): High (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF593,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000142698,True,compatible,,True,True,True,,0.35,0.3,0.214467,0,80,unavailable,0.7,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C1orf94,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000142731,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 49.6614% (minimum 75%, Missing); thymus: 61.1111% (minimum 65%, Missing)",-0.0388889,0.0508532,-0.253386,0,1,partial,22.3,7.3,14,"bone marrow: 22.3 nTPM (vital, limit 1); thymus: 14 nTPM (manageable, limit 5); lymph node: 7.3 nTPM (protected, limit 3); rectum: 4.1 nTPM (protected, limit 3); colon: 3.4 nTPM (protected, limit 3); esophagus: 3.2 nTPM (protected, limit 3); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PLK4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000142920,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 72.5581% (minimum 75%, Missing); hippocampal formation: 73.5849% (minimum 75%, Missing); midbrain: 72.8972% (minimum 75%, Missing); spinal cord: 59.0909% (minimum 75%, Missing)",0.275816,0.201734,-0.159091,0,80,unavailable,21.6,3.4,2.5,"spinal cord: 21.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); basal ganglia: 9.7 nTPM (vital, limit 1); hypothalamus: 8.5 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); cerebellum: 6.6 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); pituitary gland: 3.4 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); retina: 2.9 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AZIN2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000142945,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 69.5042% (minimum 75%, Missing)",0.0211834,0.121903,-0.0549579,0,12,partial,32.6,16.1,36.4,"thymus: 36.4 nTPM (manageable, limit 5); bone marrow: 32.6 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 3); rectum: 7.4 nTPM (protected, limit 3); colon: 6 nTPM (protected, limit 3); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); duodenum / endocrine cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Low (Enhanced); small intestine / enterocytes: Low (Enhanced); thymus / cortical cells: Medium (Enhanced); thymus / medullary cells: Medium (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KIF2C,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000143006,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0.1,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DMRTB1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000143032,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 4.7722% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); retina: 44.8980% (minimum 75%, Missing)",0.35,0.3,-0.702278,0,80,unavailable,43.9,0,0,"cerebellum: 43.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BARHL2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000143105,True,compatible,,True,True,True,,0.0166667,0.3,0.05,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KCNA10,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000143107,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 73.3333% (minimum 75%, Missing)",0.35,0.3,-0.0166667,0,4,partial,0.4,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FNDC7,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000143194,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349354,0.292298,0.223552,0,5,partial,5.4,1.2,0.1,"heart muscle: 5.4 nTPM (vital, limit 2); retina: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 2); amygdala: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAEL,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000143199,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344186,0.288439,0.0434783,0,3,partial,5.9,0.2,0.1,"liver: 5.9 nTPM (vital, limit 2)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ADCY10,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000143228,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 65.0000% (minimum 75%, Missing)",0.0227038,0.0449857,-0.1,0,80,unavailable,28,17.8,25.3,"bone marrow: 28 nTPM (vital, limit 1); thymus: 25.3 nTPM (manageable, limit 5); lymph node: 17.8 nTPM (protected, limit 3); esophagus: 5.6 nTPM (protected, limit 3); rectum: 5.1 nTPM (protected, limit 3); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); colon: 4.1 nTPM (protected, limit 3); smooth muscle: 2.2 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NUF2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000143340,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.9558% (minimum 75%, Missing); pituitary gland: 29.9270% (minimum 75%, Missing); thymus: 44.0860% (minimum 65%, Missing)",-0.20914,0.184892,-0.45073,0,80,unavailable,28.8,1.6,15.6,"pituitary gland: 28.8 nTPM (vital, limit 1); thymus: 15.6 nTPM (manageable, limit 5); adrenal gland: 5.8 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM163A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000143355,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344565,0.3,0.0856164,0,80,unavailable,3.6,0,0.1,"retina: 3.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LHX9,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000143443,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344652,0.271279,0.134661,0,4,partial,9.9,5.3,7.9,"adrenal gland: 9.9 nTPM (vital, limit 6); pituitary gland: 9.7 nTPM (vital, limit 1); liver: 8.1 nTPM (vital, limit 6); heart muscle: 7.7 nTPM (vital, limit 6); pancreas: 7.3 nTPM (vital, limit 6); kidney: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 6); choroid plexus: 5.4 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1)",kidney / proximal tubules (cell body): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C1orf56,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000143450,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.33904,0.261929,0.235439,0,80,unavailable,2.8,7.5,2.1,"salivary gland: 7.5 nTPM (protected, limit 3); parathyroid gland: 4.1 nTPM (protected, limit 3); skeletal muscle: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OAZ3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000143452,True,compatible,,True,True,True,,0.35,0.3,0.249126,0,3,partial,0.5,3.5,6.6,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HORMAD1,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,False,unchanged,
ENSG00000143469,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.1111% (minimum 75%, Missing); cerebral cortex: 62.7451% (minimum 75%, Missing); retina: 45.7143% (minimum 75%, Missing); thyroid gland: 34.7826% (minimum 65%, Missing)",-0.302174,0.269697,-0.292857,0,80,unavailable,3.8,0.1,6,"thyroid gland: 6 nTPM (manageable, limit 5); retina: 3.8 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SYT14,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000143476,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 48.0144% (minimum 75%, Missing); thymus: 49.0775% (minimum 65%, Missing)",-0.159225,0.0112299,-0.269856,0,2,partial,14.4,5.4,13.8,"bone marrow: 14.4 nTPM (vital, limit 1); thymus: 13.8 nTPM (manageable, limit 5); lymph node: 5.4 nTPM (protected, limit 3); smooth muscle: 1.8 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Supported); esophagus / squamous epithelial cells: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); skin 2 / epidermal cells: Low (Supported); smooth muscle / smooth muscle cells: Low (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DTL,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000143479,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.201648,0.165922,0.0923913,0,80,unavailable,8.7,7.2,8.1,"bone marrow: 8.7 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); heart muscle: 8 nTPM (vital, limit 1); smooth muscle: 7.9 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (manageable, limit 5); urinary bladder: 7.2 nTPM (protected, limit 3); pituitary gland: 6.3 nTPM (vital, limit 1); retina: 6.2 nTPM (vital, limit 1); thymus: 5.8 nTPM (manageable, limit 5); lung: 5.3 nTPM (vital, limit 1); salivary gland: 4.1 nTPM (protected, limit 3); liver: 4 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DYRK3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000143494,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 66.3793% (minimum 70%, Missing)",0.00254237,-0.0362069,0.00490196,0,80,unavailable,2.5,3.9,4.1,"esophagus: 3.9 nTPM (protected, limit 3); pituitary gland: 2.5 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,VASH2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000143498,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 64.8936% (minimum 75%, Missing); bone marrow: 69.3182% (minimum 75%, Missing); cerebral cortex: 67.0330% (minimum 75%, Missing); duodenum: 71.7647% (minimum 75%, Missing); hypothalamus: 74.3902% (minimum 75%, Missing); lung: 69.3182% (minimum 75%, Missing); lymph node: 49.1935% (minimum 70%, Missing); pituitary gland: 71.7647% (minimum 75%, Missing); retina: 61.0000% (minimum 75%, Missing); small intestine: 72.6190% (minimum 75%, Missing); smooth muscle: 71.7647% (minimum 75%, Missing); spleen: 58.6538% (minimum 65%, Missing); stomach: 64.8936% (minimum 70%, Missing); thymus: 58.6538% (minimum 65%, Missing); thyroid gland: 55.4545% (minimum 65%, Missing); urinary bladder: 54.4643% (minimum 70%, Missing)",-0.0954545,-0.208065,-0.14,0,5,partial,3.9,6.3,4.9,"lymph node: 6.3 nTPM (protected, limit 3); urinary bladder: 5.1 nTPM (protected, limit 3); retina: 3.9 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 3); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TAF1A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000143512,True,compatible,,True,True,True,,0.212121,0.274561,0.229167,0,2,partial,0.3,1,1.9,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HHIPL2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000143552,True,compatible,,True,True,True,,0.35,0.3,0.227273,0,2,partial,0.6,0.3,0.2,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NUP210L,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000143702,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 62.6705% (minimum 75%, Uncertain)",0.229154,0.232692,-0.123295,0,5,partial,52,6.3,12,"bone marrow: 52 nTPM (vital, limit 1); cerebellum: 24.6 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); cerebral cortex: 16.9 nTPM (vital, limit 1); thyroid gland: 12 nTPM (manageable, limit 5); retina: 10.6 nTPM (vital, limit 1); thymus: 10.5 nTPM (manageable, limit 5); skeletal muscle: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); hypothalamus: 8.8 nTPM (vital, limit 1); lung: 8.3 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); adipose tissue: 7.8 nTPM (manageable, limit 5); heart muscle: 7.2 nTPM (vital, limit 1); spleen: 6.6 nTPM (manageable, limit 5); amygdala: 6.5 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); urinary bladder: 6.3 nTPM (protected, limit 3); lymph node: 6.3 nTPM (protected, limit 3); liver: 6.2 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 1); tongue: 5.6 nTPM (protected, limit 3); colon: 5.3 nTPM (protected, limit 3); adrenal gland: 4.9 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); pituitary gland: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); stomach: 3.2 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CEP170,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000143751,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 40.2827% (minimum 65%, Missing); adrenal gland: 57.8680% (minimum 75%, Missing); amygdala: 67.4556% (minimum 75%, Missing); basal ganglia: 69.9387% (minimum 75%, Missing); bone marrow: 26.0274% (minimum 75%, Missing); cerebellum: 73.0769% (minimum 75%, Missing); cerebral cortex: 62.2951% (minimum 75%, Missing); colon: 58.7629% (minimum 70%, Missing); duodenum: 56.7164% (minimum 75%, Missing); esophagus: 55.0725% (minimum 70%, Missing); heart muscle: 60.6383% (minimum 75%, Missing); hippocampal formation: 67.4556% (minimum 75%, Missing); hypothalamus: 67.0588% (minimum 75%, Missing); kidney: 56.1576% (minimum 75%, Missing); liver: 44.7059% (minimum 75%, Missing); lung: 56.1576% (minimum 75%, Missing); lymph node: 48.5106% (minimum 70%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 55.0725% (minimum 75%, Missing); parathyroid gland: 51.3514% (minimum 70%, Missing); pituitary gland: 73.0769% (minimum 75%, Missing); rectum: 56.4356% (minimum 70%, Missing); retina: 69.9387% (minimum 75%, Missing); salivary gland: 63.6872% (minimum 70%, Missing); skeletal muscle: 48.1013% (minimum 75%, Missing); skin: 52.2936% (minimum 65%, Missing); small intestine: 56.7164% (minimum 75%, Missing); smooth muscle: 54.8077% (minimum 75%, Missing); spinal cord: 61.9565% (minimum 75%, Missing); spleen: 53.0233% (minimum 65%, Missing); stomach: 60.3175% (minimum 70%, Missing); thymus: 33.9286% (minimum 65%, Missing); thyroid gland: 48.5106% (minimum 65%, Missing); tongue: 55.0725% (minimum 70%, Missing); urinary bladder: 50.4425% (minimum 70%, Missing)",-0.310714,-0.214894,-0.489726,0,1,partial,32.4,12.1,22.2,"bone marrow: 32.4 nTPM (vital, limit 1); thymus: 22.2 nTPM (manageable, limit 5); adipose tissue: 16.9 nTPM (manageable, limit 5); liver: 14.1 nTPM (vital, limit 1); skeletal muscle: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (manageable, limit 5); lymph node: 12.1 nTPM (protected, limit 3); urinary bladder: 11.2 nTPM (protected, limit 3); parathyroid gland: 10.8 nTPM (protected, limit 3); skin: 10.4 nTPM (manageable, limit 5); spleen: 10.1 nTPM (manageable, limit 5); smooth muscle: 9.4 nTPM (vital, limit 1); esophagus: 9.3 nTPM (protected, limit 3); tongue: 9.3 nTPM (protected, limit 3); pancreas: 9.3 nTPM (vital, limit 1); kidney: 8.9 nTPM (vital, limit 1); lung: 8.9 nTPM (vital, limit 1); rectum: 8.8 nTPM (protected, limit 3); duodenum: 8.7 nTPM (vital, limit 1); small intestine: 8.7 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); colon: 8 nTPM (protected, limit 3); stomach: 7.5 nTPM (protected, limit 3); heart muscle: 7.4 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); salivary gland: 6.5 nTPM (protected, limit 3); midbrain: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SDE2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000143951,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1111% (minimum 65%, Missing); adrenal gland: 58.2278% (minimum 75%, Uncertain); basal ganglia: 69.6970% (minimum 75%, Missing); bone marrow: 38.6555% (minimum 75%, Uncertain); cerebral cortex: 53.4884% (minimum 75%, Missing); choroid plexus: 51.6854% (minimum 75%, Missing); duodenum: 74.1935% (minimum 75%, Missing); heart muscle: 50.0000% (minimum 75%, Missing); hippocampal formation: 73.0159% (minimum 75%, Missing); hypothalamus: 74.1935% (minimum 75%, Missing); kidney: 58.2278% (minimum 75%, Missing); liver: 67.6471% (minimum 75%, Uncertain); lung: 65.7143% (minimum 75%, Missing); lymph node: 59.7403% (minimum 70%, Missing); parathyroid gland: 62.1622% (minimum 70%, Missing); pituitary gland: 70.7692% (minimum 75%, Missing); retina: 28.5714% (minimum 75%, Missing); salivary gland: 69.6970% (minimum 70%, Missing); skeletal muscle: 48.9362% (minimum 75%, Missing); skin: 59.7403% (minimum 65%, Missing); smooth muscle: 62.1622% (minimum 75%, Uncertain); spinal cord: 68.6567% (minimum 75%, Missing); spleen: 59.7403% (minimum 65%, Uncertain); stomach: 58.9744% (minimum 70%, Missing); thymus: 57.5000% (minimum 65%, Missing); thyroid gland: 58.9744% (minimum 65%, Missing); tongue: 62.1622% (minimum 70%, Missing)",-0.138889,-0.110256,-0.464286,0,3,partial,11.5,3.2,4.4,"retina: 11.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); cerebral cortex: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 3); lymph node: 3.1 nTPM (protected, limit 3); smooth muscle: 2.8 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,WDPCP,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000143994,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.300226,0.229204,0.117769,0,6,partial,3.2,1.6,1.1,"liver: 3.2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ABHD1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000144010,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebral cortex: 75.0000% (minimum 75%, Missing); thymus: 50.0000% (minimum 65%, Missing)",-0.15,0.3,-1.11022e-16,0,80,unavailable,0.1,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TRIM43B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000144015,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 75.0000% (minimum 75%, Missing); cerebellum: 75.0000% (minimum 75%, Missing); stomach: 60.0000% (minimum 70%, Missing); thymus: 50.0000% (minimum 65%, Missing)",-0.15,-0.1,-1.11022e-16,0,80,unavailable,0.1,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRIM43,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000144061,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 39.3791% (minimum 75%, Missing); parathyroid gland: 59.5062% (minimum 65%, Approved); pituitary gland: 67.8873% (minimum 75%, Missing); retina: 69.8551% (minimum 75%, Missing); skeletal muscle: 40.7783% (minimum 75%, Missing)",0.119968,-0.0549383,-0.356209,0,4,partial,37.1,16.4,7.2,"choroid plexus: 37.1 nTPM (vital, limit 1); skeletal muscle: 35 nTPM (vital, limit 1); parathyroid gland: 16.4 nTPM (protected, limit 4); pituitary gland: 11.4 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 3); kidney: 7.8 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 3); amygdala: 4.9 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); smooth muscle: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 3); midbrain: 3.8 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pituitary gland / cells in anterior : Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NPHP1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000144130,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 67.5676% (minimum 75%, Missing)",0.242857,0.0575758,-0.0743243,0,80,unavailable,1.2,0.8,0.3,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NT5DC4,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,False,False,False,False,unchanged,
ENSG00000144182,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 64.6226% (minimum 75%, Missing); amygdala: 72.1053% (minimum 75%, Missing); basal ganglia: 69.5431% (minimum 75%, Missing); bone marrow: 52.8958% (minimum 70%, Approved); cerebral cortex: 74.8634% (minimum 75%, Missing); colon: 67.8218% (minimum 70%, Missing); duodenum: 62.8440% (minimum 75%, Missing); heart muscle: 62.5571% (minimum 75%, Missing); hippocampal formation: 69.5431% (minimum 75%, Missing); hypothalamus: 72.4868% (minimum 75%, Missing); kidney: 55.6911% (minimum 75%, Missing); liver: 63.4259% (minimum 75%, Missing); lymph node: 56.8465% (minimum 65%, Approved); midbrain: 66.5049% (minimum 75%, Missing); pancreas: 66.1836% (minimum 75%, Missing); pituitary gland: 67.8218% (minimum 75%, Missing); rectum: 66.1836% (minimum 70%, Missing); retina: 65.2381% (minimum 75%, Missing); salivary gland: 61.1607% (minimum 65%, Approved); skeletal muscle: 60.8889% (minimum 75%, Missing); small intestine: 62.8440% (minimum 70%, Approved); spinal cord: 65.5502% (minimum 75%, Missing); spleen: 54.1502% (minimum 60%, Approved); stomach: 67.1569% (minimum 70%, Missing); thyroid gland: 55.4656% (minimum 60%, Approved); tongue: 61.4350% (minimum 70%, Missing); urinary bladder: 69.1919% (minimum 70%, Missing)",-0.058498,-0.0856502,-0.193089,0,7,partial,12.2,10.4,11.6,"bone marrow: 12.2 nTPM (vital, limit 2); spleen: 11.6 nTPM (manageable, limit 10); thyroid gland: 11 nTPM (manageable, limit 10); kidney: 10.9 nTPM (vital, limit 1); lymph node: 10.4 nTPM (protected, limit 4); skeletal muscle: 8.8 nTPM (vital, limit 1); salivary gland: 8.7 nTPM (protected, limit 4); tongue: 8.6 nTPM (protected, limit 3); heart muscle: 8.2 nTPM (vital, limit 1); duodenum: 8.1 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 2); liver: 7.9 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 3); pancreas: 7 nTPM (vital, limit 1); adipose tissue: 6.9 nTPM (manageable, limit 5); midbrain: 6.9 nTPM (vital, limit 1); skin: 6.8 nTPM (manageable, limit 5); stomach: 6.7 nTPM (protected, limit 3); pituitary gland: 6.5 nTPM (vital, limit 1); colon: 6.5 nTPM (protected, limit 3); urinary bladder: 6.1 nTPM (protected, limit 3); parathyroid gland: 6.1 nTPM (protected, limit 4); basal ganglia: 6 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 2); smooth muscle: 5.4 nTPM (vital, limit 2); cerebellum: 5.4 nTPM (vital, limit 2); amygdala: 5.3 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); hypothalamus: 5.2 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 4); cerebral cortex: 4.6 nTPM (vital, limit 1); choroid plexus: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LIPT1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000144395,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 65.7534% (minimum 75%, Missing)",0.177586,0.26,-0.0924658,0,80,unavailable,2.5,0.2,1,"kidney: 2.5 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC150,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000144401,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.6296% (minimum 65%, Missing); adrenal gland: 57.5610% (minimum 75%, Missing); amygdala: 42.4460% (minimum 75%, Missing); basal ganglia: 40.1361% (minimum 75%, Missing); bone marrow: 34.8083% (minimum 75%, Missing); cerebellum: 47.7733% (minimum 75%, Missing); cerebral cortex: 40.8304% (minimum 75%, Missing); choroid plexus: 45.5598% (minimum 75%, Missing); colon: 57.0048% (minimum 70%, Missing); duodenum: 62.4339% (minimum 75%, Missing); esophagus: 64.4809% (minimum 70%, Missing); heart muscle: 47.2000% (minimum 75%, Missing); hippocampal formation: 44.0299% (minimum 75%, Missing); hypothalamus: 43.2234% (minimum 75%, Missing); kidney: 51.9824% (minimum 75%, Missing); liver: 33.8109% (minimum 75%, Missing); lung: 59.5960% (minimum 75%, Missing); lymph node: 42.4460% (minimum 70%, Missing); midbrain: 38.5621% (minimum 75%, Missing); pancreas: 57.8431% (minimum 75%, Missing); parathyroid gland: 55.3991% (minimum 70%, Uncertain); pituitary gland: 55.1402% (minimum 75%, Missing); rectum: 57.8431% (minimum 70%, Missing); retina: 45.3846% (minimum 75%, Missing); salivary gland: 60.2041% (minimum 70%, Missing); skeletal muscle: 44.0299% (minimum 75%, Uncertain); small intestine: 57.8431% (minimum 75%, Missing); smooth muscle: 61.4583% (minimum 75%, Missing); spinal cord: 37.3418% (minimum 75%, Missing); spleen: 45.0382% (minimum 65%, Missing); stomach: 52.6786% (minimum 70%, Missing); thymus: 40.6897% (minimum 65%, Missing); thyroid gland: 49.7890% (minimum 65%, Missing); tongue: 58.1281% (minimum 70%, Missing); urinary bladder: 59.0000% (minimum 70%, Missing)",-0.243103,-0.27554,-0.411891,0,1,partial,23.1,16,17.2,"liver: 23.1 nTPM (vital, limit 1); bone marrow: 22.1 nTPM (vital, limit 1); spinal cord: 19.8 nTPM (vital, limit 1); midbrain: 18.8 nTPM (vital, limit 1); basal ganglia: 17.6 nTPM (vital, limit 1); thymus: 17.2 nTPM (manageable, limit 5); cerebral cortex: 17.1 nTPM (vital, limit 1); lymph node: 16 nTPM (protected, limit 3); amygdala: 16 nTPM (vital, limit 1); hypothalamus: 15.5 nTPM (vital, limit 1); hippocampal formation: 15 nTPM (vital, limit 1); skeletal muscle: 15 nTPM (vital, limit 1); spleen: 14.4 nTPM (manageable, limit 5); retina: 14.2 nTPM (vital, limit 1); choroid plexus: 14.1 nTPM (vital, limit 1); heart muscle: 13.2 nTPM (vital, limit 1); cerebellum: 12.9 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); kidney: 10.9 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 3); adipose tissue: 9.8 nTPM (manageable, limit 5); pituitary gland: 9.6 nTPM (vital, limit 1); parathyroid gland: 9.5 nTPM (protected, limit 3); colon: 8.9 nTPM (protected, limit 3); adrenal gland: 8.7 nTPM (vital, limit 1); rectum: 8.6 nTPM (protected, limit 3); pancreas: 8.6 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 3); urinary bladder: 8.2 nTPM (protected, limit 3); lung: 8 nTPM (vital, limit 1); salivary gland: 7.8 nTPM (protected, limit 3); smooth muscle: 7.4 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); esophagus: 6.5 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,METTL21A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000144445,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"heart muscle: 72.3529% (minimum 75%, Missing); kidney: 52.9032% (minimum 75%, Missing); liver: 72.9970% (minimum 75%, Missing); lung: 68.1440% (minimum 75%, Missing); pancreas: 62.5954% (minimum 75%, Missing); parathyroid gland: 11.3364% (minimum 70%, Missing); pituitary gland: 71.7201% (minimum 75%, Missing); retina: 66.8478% (minimum 75%, Missing); skeletal muscle: 67.9558% (minimum 75%, Missing); smooth muscle: 65.7754% (minimum 75%, Missing); stomach: 66.8478% (minimum 70%, Missing); thymus: 48.6166% (minimum 65%, Missing); thyroid gland: 56.2929% (minimum 65%, Missing); tongue: 58.1560% (minimum 70%, Missing); urinary bladder: 65.0794% (minimum 70%, Missing)",-0.163834,-0.586636,-0.220968,0,3,partial,21.9,192.4,26,"parathyroid gland: 192.4 nTPM (protected, limit 3); thymus: 26 nTPM (manageable, limit 5); kidney: 21.9 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); tongue: 17.7 nTPM (protected, limit 3); pancreas: 14.7 nTPM (vital, limit 1); urinary bladder: 13.2 nTPM (protected, limit 3); skin: 12.9 nTPM (manageable, limit 5); smooth muscle: 12.8 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 3); retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (manageable, limit 5); pituitary gland: 9.7 nTPM (vital, limit 1); salivary gland: 9.7 nTPM (protected, limit 3); colon: 9.6 nTPM (protected, limit 3); heart muscle: 9.4 nTPM (vital, limit 1); liver: 9.1 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); spinal cord: 6.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 3); rectum: 6.6 nTPM (protected, limit 3); small intestine: 6.6 nTPM (vital, limit 1); lymph node: 6.5 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); midbrain: 5.7 nTPM (vital, limit 1); bone marrow: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KANSL1L,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000144488,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 33.8710% (minimum 75%, Missing); liver: 56.7568% (minimum 75%, Missing); pituitary gland: 51.2195% (minimum 75%, Missing); small intestine: 38.1818% (minimum 75%, Missing)",0.00625,0.0241379,-0.41129,0,80,unavailable,4.1,0.8,1.1,"cerebellum: 4.1 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ESPNL,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000144619,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 73.5955% (minimum 75%, Missing); cerebral cortex: 63.5922% (minimum 75%, Missing); parathyroid gland: 37.5358% (minimum 70%, Missing); retina: 40.5573% (minimum 75%, Missing); thyroid gland: 56.7100% (minimum 65%, Missing)",-0.0829004,-0.324642,-0.344427,0,80,unavailable,19.2,21.8,10,"parathyroid gland: 21.8 nTPM (protected, limit 3); retina: 19.2 nTPM (vital, limit 1); thyroid gland: 10 nTPM (manageable, limit 5); cerebral cortex: 7.5 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 3); smooth muscle: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 3); stomach: 3.5 nTPM (protected, limit 3); urinary bladder: 3.5 nTPM (protected, limit 3); rectum: 3.2 nTPM (protected, limit 3); liver: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CNTN4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000144671,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341228,0.282609,0.146825,0,80,unavailable,1.3,0.2,0.1,"cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC22A14,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000144792,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 58.9286% (minimum 75%, Missing); hypothalamus: 73.3333% (minimum 75%, Missing); pituitary gland: 57.8947% (minimum 75%, Missing); retina: 42.8571% (minimum 75%, Missing); spinal cord: 75.0000% (minimum 75%, Missing)",0.0375,0.00212766,-0.321429,0,80,unavailable,4.4,1.4,1.5,"retina: 4.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF660,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000144821,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 30.0000% (minimum 75%, Missing); basal ganglia: 33.3333% (minimum 75%, Missing); cerebellum: 50.0000% (minimum 75%, Missing); cerebral cortex: 33.3333% (minimum 75%, Missing); choroid plexus: 75.0000% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Uncertain); duodenum: 60.0000% (minimum 75%, Uncertain); heart muscle: 60.0000% (minimum 75%, Missing); hippocampal formation: 30.0000% (minimum 75%, Missing); hypothalamus: 33.3333% (minimum 75%, Missing); lung: 66.6667% (minimum 75%, Missing); midbrain: 25.0000% (minimum 75%, Missing); pituitary gland: 42.8571% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Uncertain); retina: 16.2162% (minimum 75%, Missing); skeletal muscle: 75.0000% (minimum 75%, Missing); skin: 54.5455% (minimum 65%, Missing); small intestine: 50.0000% (minimum 75%, Missing); spinal cord: 26.0870% (minimum 75%, Missing); tongue: 23.0769% (minimum 70%, Missing)",-0.104545,-0.469231,-0.587838,0,1,partial,3.1,2,0.5,"retina: 3.1 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MYH15,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000144840,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 44.9735% (minimum 65%, Missing); adrenal gland: 35.2697% (minimum 75%, Uncertain); amygdala: 47.2222% (minimum 75%, Missing); basal ganglia: 44.2708% (minimum 75%, Missing); bone marrow: 61.5942% (minimum 75%, Missing); cerebellum: 49.4186% (minimum 75%, Missing); cerebral cortex: 46.4481% (minimum 75%, Missing); choroid plexus: 62.9630% (minimum 75%, Missing); colon: 51.8293% (minimum 70%, Missing); duodenum: 61.5942% (minimum 75%, Missing); esophagus: 52.4691% (minimum 70%, Missing); heart muscle: 54.8387% (minimum 75%, Missing); hippocampal formation: 49.7076% (minimum 75%, Missing); hypothalamus: 46.4481% (minimum 75%, Missing); kidney: 47.2222% (minimum 75%, Missing); liver: 47.4860% (minimum 75%, Missing); lung: 61.1511% (minimum 75%, Missing); lymph node: 59.4406% (minimum 70%, Uncertain); midbrain: 41.4634% (minimum 75%, Missing); pancreas: 57.8231% (minimum 75%, Missing); parathyroid gland: 42.7136% (minimum 70%, Missing); pituitary gland: 58.2192% (minimum 75%, Missing); rectum: 50.5952% (minimum 70%, Missing); retina: 60.2837% (minimum 75%, Missing); salivary gland: 55.9211% (minimum 70%, Missing); skeletal muscle: 38.9908% (minimum 75%, Missing); skin: 58.2192% (minimum 65%, Missing); small intestine: 59.4406% (minimum 75%, Missing); smooth muscle: 58.6207% (minimum 75%, Missing); spinal cord: 37.9464% (minimum 75%, Missing); spleen: 61.1511% (minimum 65%, Uncertain); stomach: 55.1948% (minimum 70%, Missing); thymus: 57.8231% (minimum 65%, Missing); thyroid gland: 41.6667% (minimum 65%, Missing); tongue: 42.7136% (minimum 70%, Missing); urinary bladder: 54.4872% (minimum 70%, Missing)",-0.233333,-0.272864,-0.397303,0,4,partial,15.6,11.4,11.9,"adrenal gland: 15.6 nTPM (vital, limit 1); spinal cord: 13.9 nTPM (vital, limit 1); skeletal muscle: 13.3 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); thyroid gland: 11.9 nTPM (manageable, limit 5); tongue: 11.4 nTPM (protected, limit 3); parathyroid gland: 11.4 nTPM (protected, limit 3); basal ganglia: 10.7 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (manageable, limit 5); hypothalamus: 9.8 nTPM (vital, limit 1); cerebral cortex: 9.8 nTPM (vital, limit 1); amygdala: 9.5 nTPM (vital, limit 1); kidney: 9.5 nTPM (vital, limit 1); liver: 9.4 nTPM (vital, limit 1); cerebellum: 8.7 nTPM (vital, limit 1); hippocampal formation: 8.6 nTPM (vital, limit 1); rectum: 8.3 nTPM (protected, limit 3); colon: 7.9 nTPM (protected, limit 3); esophagus: 7.7 nTPM (protected, limit 3); urinary bladder: 7.1 nTPM (protected, limit 3); heart muscle: 7 nTPM (vital, limit 1); stomach: 6.9 nTPM (protected, limit 3); salivary gland: 6.7 nTPM (protected, limit 3); pancreas: 6.2 nTPM (vital, limit 1); thymus: 6.2 nTPM (manageable, limit 5); pituitary gland: 6.1 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); smooth muscle: 6 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 3); small intestine: 5.8 nTPM (vital, limit 1); retina: 5.6 nTPM (vital, limit 1); lung: 5.4 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); bone marrow: 5.3 nTPM (vital, limit 1); duodenum: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RABL3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000144893,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.1754% (minimum 75%, Missing); amygdala: 55.5556% (minimum 75%, Missing); basal ganglia: 58.8235% (minimum 75%, Missing); bone marrow: 51.2821% (minimum 60%, Enhanced); cerebellum: 61.5385% (minimum 75%, Missing); cerebral cortex: 52.6316% (minimum 75%, Missing); choroid plexus: 59.7015% (minimum 75%, Missing); hippocampal formation: 61.5385% (minimum 75%, Missing); hypothalamus: 61.5385% (minimum 75%, Missing); midbrain: 57.1429% (minimum 75%, Missing); pituitary gland: 71.4286% (minimum 75%, Missing); retina: 59.7015% (minimum 75%, Missing); spinal cord: 61.5385% (minimum 75%, Missing)",0.259091,0.25,-0.223684,0,1,partial,3.8,1,0.7,"cerebral cortex: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MED12L,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000144962,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA16,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000145040,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 56.5789% (minimum 70%, Missing); skin: 25.1462% (minimum 65%, Missing)",-0.398538,-0.134211,0.00438596,0,80,unavailable,1.4,3.3,12.8,"skin: 12.8 nTPM (manageable, limit 5); esophagus: 3.3 nTPM (protected, limit 3); kidney: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,UCN2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000145216,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.4490% (minimum 65%, Missing); adrenal gland: 66.8122% (minimum 75%, Missing); amygdala: 73.5577% (minimum 75%, Missing); bone marrow: 52.3973% (minimum 75%, Missing); cerebellum: 70.6697% (minimum 75%, Missing); cerebral cortex: 69.7039% (minimum 75%, Missing); colon: 68.7640% (minimum 70%, Missing); duodenum: 73.5577% (minimum 75%, Missing); esophagus: 66.5217% (minimum 70%, Missing); heart muscle: 70.9977% (minimum 75%, Missing); kidney: 70.3448% (minimum 75%, Missing); liver: 70.1835% (minimum 75%, Missing); lung: 68.9189% (minimum 75%, Missing); lymph node: 61.8182% (minimum 70%, Missing); midbrain: 74.6341% (minimum 75%, Missing); rectum: 68.1514% (minimum 70%, Missing); retina: 65.2452% (minimum 75%, Missing); skeletal muscle: 55.1351% (minimum 75%, Missing); skin: 63.8831% (minimum 65%, Missing); small intestine: 68.6099% (minimum 75%, Missing); smooth muscle: 67.4009% (minimum 75%, Missing); spinal cord: 71.1628% (minimum 75%, Missing); stomach: 69.5455% (minimum 70%, Missing); thymus: 51.4286% (minimum 65%, Missing); urinary bladder: 64.4211% (minimum 70%, Missing)",-0.135714,-0.0818182,-0.226027,0,7,partial,27.8,18.9,28.9,"thymus: 28.9 nTPM (manageable, limit 5); bone marrow: 27.8 nTPM (vital, limit 1); skeletal muscle: 24.9 nTPM (vital, limit 1); lymph node: 18.9 nTPM (protected, limit 3); adipose tissue: 18.4 nTPM (manageable, limit 5); skin: 17.3 nTPM (manageable, limit 5); urinary bladder: 16.9 nTPM (protected, limit 3); parathyroid gland: 16.7 nTPM (protected, limit 6); retina: 16.3 nTPM (vital, limit 1); esophagus: 15.4 nTPM (protected, limit 3); adrenal gland: 15.2 nTPM (vital, limit 1); thyroid gland: 14.9 nTPM (manageable, limit 5); smooth muscle: 14.8 nTPM (vital, limit 1); rectum: 14.3 nTPM (protected, limit 3); salivary gland: 14.2 nTPM (protected, limit 6); small intestine: 14 nTPM (vital, limit 1); colon: 13.9 nTPM (protected, limit 3); lung: 13.8 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 3); cerebral cortex: 13.3 nTPM (vital, limit 1); liver: 13 nTPM (vital, limit 1); kidney: 12.9 nTPM (vital, limit 1); cerebellum: 12.7 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); tongue: 11.9 nTPM (protected, limit 3); duodenum: 11 nTPM (vital, limit 1); amygdala: 11 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); pituitary gland: 9.4 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / neuronal cells: Low (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); nasopharynx / goblet cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); rectum / glandular cells: High (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FIP1L1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000145309,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,3.9,0,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CABS1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,False,unchanged,
ENSG00000145331,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.7273% (minimum 75%, Missing); duodenum: 69.5652% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 50.2618% (minimum 75%, Missing); lymph node: 69.0647% (minimum 70%, Missing); pancreas: 62.7451% (minimum 75%, Missing); skeletal muscle: 71.6418% (minimum 75%, Missing); small intestine: 68.5714% (minimum 75%, Missing); spinal cord: 71.6418% (minimum 75%, Missing); stomach: 69.0647% (minimum 70%, Missing); thyroid gland: 61.9355% (minimum 65%, Missing)",-0.0306452,-0.00935252,-0.247382,0,80,unavailable,9.5,4.3,5.9,"liver: 9.5 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); pancreas: 5.7 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 1); small intestine: 4.4 nTPM (vital, limit 1); stomach: 4.3 nTPM (protected, limit 3); lymph node: 4.3 nTPM (protected, limit 3); duodenum: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 3); parathyroid gland: 3.6 nTPM (protected, limit 3); adrenal gland: 3.6 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); rectum: 3.5 nTPM (protected, limit 3); colon: 3.5 nTPM (protected, limit 3); cerebral cortex: 3.1 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRMT10A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000145375,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 71.4286% (minimum 75%, Missing); retina: 61.4035% (minimum 75%, Missing); stomach: 60.3448% (minimum 70%, Missing); thymus: 63.6364% (minimum 65%, Missing)",-0.0136364,-0.0965517,-0.135965,0,0,routine_complete,2.2,2.3,2,"retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AFG2A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000145491,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.349363,0.299045,0.216154,0,4,partial,11,0.4,4.3,"choroid plexus: 11 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ROPN1L,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000145743,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.1538% (minimum 65%, Missing); adrenal gland: 50.0000% (minimum 75%, Missing); bone marrow: 68.9189% (minimum 75%, Missing); cerebral cortex: 37.7778% (minimum 75%, Missing); colon: 57.3034% (minimum 70%, Missing); duodenum: 56.0440% (minimum 75%, Missing); esophagus: 53.9683% (minimum 70%, Missing); heart muscle: 34.0000% (minimum 75%, Missing); kidney: 44.7368% (minimum 75%, Missing); liver: 49.0385% (minimum 75%, Uncertain); lung: 60.7143% (minimum 75%, Missing); lymph node: 61.4458% (minimum 70%, Uncertain); pancreas: 57.9545% (minimum 75%, Missing); parathyroid gland: 34.9315% (minimum 70%, Uncertain); rectum: 56.9832% (minimum 70%, Missing); retina: 35.0515% (minimum 75%, Missing); salivary gland: 57.9545% (minimum 70%, Missing); skeletal muscle: 19.5402% (minimum 75%, Missing); skin: 60.7143% (minimum 65%, Missing); small intestine: 55.7377% (minimum 75%, Missing); smooth muscle: 54.5455% (minimum 75%, Missing); spleen: 55.4348% (minimum 65%, Missing); stomach: 56.9832% (minimum 70%, Uncertain); thymus: 57.9545% (minimum 65%, Missing); thyroid gland: 36.0424% (minimum 65%, Uncertain); tongue: 25.0614% (minimum 70%, Missing); urinary bladder: 62.1951% (minimum 70%, Missing)",-0.289576,-0.449386,-0.554598,0,6,partial,42,30.5,18.1,"skeletal muscle: 42 nTPM (vital, limit 1); tongue: 30.5 nTPM (protected, limit 3); heart muscle: 19.8 nTPM (vital, limit 1); parathyroid gland: 19 nTPM (protected, limit 3); retina: 18.9 nTPM (vital, limit 1); thyroid gland: 18.1 nTPM (manageable, limit 5); cerebral cortex: 16.8 nTPM (vital, limit 1); kidney: 12.6 nTPM (vital, limit 1); adipose tissue: 11.9 nTPM (manageable, limit 5); liver: 10.6 nTPM (vital, limit 1); adrenal gland: 10.2 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 3); smooth muscle: 8.5 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 3); rectum: 7.7 nTPM (protected, limit 3); colon: 7.6 nTPM (protected, limit 3); thymus: 7.4 nTPM (manageable, limit 5); pancreas: 7.4 nTPM (vital, limit 1); salivary gland: 7.4 nTPM (protected, limit 3); skin: 6.6 nTPM (manageable, limit 5); lung: 6.6 nTPM (vital, limit 1); lymph node: 6.4 nTPM (protected, limit 3); urinary bladder: 6.2 nTPM (protected, limit 3); bone marrow: 4.6 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FBXL17,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000145757,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.292366,0.238593,0,4,partial,0.3,0.2,1,,caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA9,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000145850,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.215266,0.0220217,0.148588,0,4,partial,15.8,53.9,21.8,"lymph node: 53.9 nTPM (protected, limit 3); thymus: 21.8 nTPM (manageable, limit 5); bone marrow: 15.8 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 2); adipose tissue: 14.3 nTPM (manageable, limit 10); spleen: 7.8 nTPM (manageable, limit 5); urinary bladder: 4.7 nTPM (protected, limit 4); kidney: 3.3 nTPM (vital, limit 2); choroid plexus: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TIMD4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000145868,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.2075% (minimum 60%, Approved); adrenal gland: 55.9524% (minimum 75%, Missing); amygdala: 67.4641% (minimum 75%, Missing); basal ganglia: 65.5814% (minimum 75%, Missing); bone marrow: 59.2437% (minimum 70%, Approved); cerebellum: 56.1753% (minimum 75%, Missing); cerebral cortex: 60.7759% (minimum 75%, Missing); choroid plexus: 64.3836% (minimum 75%, Missing); colon: 53.8168% (minimum 70%, Missing); duodenum: 60.0000% (minimum 75%, Missing); esophagus: 58.0247% (minimum 70%, Missing); heart muscle: 45.6311% (minimum 75%, Missing); hippocampal formation: 64.9770% (minimum 75%, Missing); hypothalamus: 65.8879% (minimum 75%, Missing); kidney: 53.0075% (minimum 75%, Missing); liver: 44.6203% (minimum 75%, Missing); lung: 50.0000% (minimum 75%, Missing); lymph node: 49.8233% (minimum 65%, Approved); midbrain: 64.6789% (minimum 75%, Missing); pancreas: 60.5150% (minimum 75%, Missing); parathyroid gland: 44.0625% (minimum 70%, Missing); pituitary gland: 58.7500% (minimum 75%, Missing); rectum: 52.8090% (minimum 70%, Missing); retina: 57.0850% (minimum 75%, Missing); salivary gland: 55.7312% (minimum 70%, Missing); skeletal muscle: 43.9252% (minimum 70%, Approved); skin: 54.4402% (minimum 65%, Missing); small intestine: 55.5118% (minimum 75%, Missing); smooth muscle: 54.4402% (minimum 75%, Missing); spinal cord: 60.2564% (minimum 75%, Missing); spleen: 50.1779% (minimum 60%, Approved); stomach: 53.8168% (minimum 70%, Missing); thymus: 41.7160% (minimum 65%, Missing); thyroid gland: 54.2308% (minimum 65%, Missing); tongue: 46.5347% (minimum 70%, Missing); urinary bladder: 51.4599% (minimum 70%, Missing)",-0.23284,-0.259375,-0.303797,0,3,partial,18,17.9,19.7,"thymus: 19.7 nTPM (manageable, limit 5); skeletal muscle: 18 nTPM (vital, limit 2); parathyroid gland: 17.9 nTPM (protected, limit 3); liver: 17.5 nTPM (vital, limit 1); heart muscle: 16.8 nTPM (vital, limit 1); tongue: 16.2 nTPM (protected, limit 3); lymph node: 14.2 nTPM (protected, limit 4); lung: 14.1 nTPM (vital, limit 1); spleen: 14 nTPM (manageable, limit 10); urinary bladder: 13.3 nTPM (protected, limit 3); rectum: 12.6 nTPM (protected, limit 3); kidney: 12.5 nTPM (vital, limit 1); adipose tissue: 12.4 nTPM (manageable, limit 10); colon: 12.1 nTPM (protected, limit 3); stomach: 12.1 nTPM (protected, limit 3); thyroid gland: 11.9 nTPM (manageable, limit 5); smooth muscle: 11.8 nTPM (vital, limit 1); skin: 11.8 nTPM (manageable, limit 5); small intestine: 11.3 nTPM (vital, limit 1); salivary gland: 11.2 nTPM (protected, limit 3); adrenal gland: 11.1 nTPM (vital, limit 1); cerebellum: 11 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); esophagus: 10.2 nTPM (protected, limit 3); pituitary gland: 9.9 nTPM (vital, limit 1); bone marrow: 9.7 nTPM (vital, limit 2); duodenum: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); choroid plexus: 7.8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.4 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FBXO38,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000145975,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.15625,0,80,unavailable,1.5,0,0,"pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM217A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000145979,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 62.5806% (minimum 75%, Missing); amygdala: 59.8765% (minimum 75%, Missing); basal ganglia: 61.5873% (minimum 75%, Missing); bone marrow: 42.6374% (minimum 70%, Approved); cerebellum: 64.4518% (minimum 70%, Approved); cerebral cortex: 51.1873% (minimum 75%, Missing); choroid plexus: 67.5958% (minimum 75%, Missing); colon: 56.8915% (minimum 65%, Approved); duodenum: 57.9104% (minimum 75%, Missing); esophagus: 53.7396% (minimum 65%, Approved); heart muscle: 38.8778% (minimum 70%, Approved); hippocampal formation: 58.7879% (minimum 75%, Missing); hypothalamus: 60.4361% (minimum 75%, Missing); kidney: 48.6216% (minimum 75%, Missing); liver: 53.1507% (minimum 75%, Missing); lung: 64.6667% (minimum 70%, Approved); lymph node: 58.7879% (minimum 65%, Approved); midbrain: 61.3924% (minimum 75%, Missing); pancreas: 66.2116% (minimum 75%, Missing); parathyroid gland: 61.7834% (minimum 70%, Missing); pituitary gland: 65.1007% (minimum 75%, Missing); rectum: 54.9575% (minimum 65%, Approved); retina: 63.6066% (minimum 75%, Missing); salivary gland: 62.1795% (minimum 65%, Approved); skeletal muscle: 55.2707% (minimum 70%, Approved); skin: 59.3272% (minimum 60%, Approved); small intestine: 64.8829% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 70%, Approved); spinal cord: 60.0619% (minimum 75%, Missing); thymus: 54.1899% (minimum 65%, Missing); tongue: 58.2583% (minimum 70%, Missing)",-0.108101,-0.117417,-0.311222,0,3,partial,30.5,16.7,16.4,"heart muscle: 30.5 nTPM (vital, limit 2); bone marrow: 26.1 nTPM (vital, limit 2); kidney: 20.5 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); liver: 17.1 nTPM (vital, limit 1); esophagus: 16.7 nTPM (protected, limit 4); thymus: 16.4 nTPM (manageable, limit 5); rectum: 15.9 nTPM (protected, limit 4); skeletal muscle: 15.7 nTPM (vital, limit 2); colon: 14.7 nTPM (protected, limit 4); duodenum: 14.1 nTPM (vital, limit 1); tongue: 13.9 nTPM (protected, limit 3); lymph node: 13.6 nTPM (protected, limit 4); hippocampal formation: 13.6 nTPM (vital, limit 1); skin: 13.3 nTPM (manageable, limit 10); amygdala: 13 nTPM (vital, limit 1); spinal cord: 12.9 nTPM (vital, limit 1); hypothalamus: 12.7 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); basal ganglia: 12.1 nTPM (vital, limit 1); spleen: 12 nTPM (manageable, limit 10); parathyroid gland: 12 nTPM (protected, limit 3); salivary gland: 11.8 nTPM (protected, limit 4); adrenal gland: 11.6 nTPM (vital, limit 1); retina: 11.1 nTPM (vital, limit 1); cerebellum: 10.7 nTPM (vital, limit 2); lung: 10.6 nTPM (vital, limit 2); small intestine: 10.5 nTPM (vital, limit 1); pituitary gland: 10.4 nTPM (vital, limit 1); pancreas: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 2); urinary bladder: 9.6 nTPM (protected, limit 4); stomach: 9.5 nTPM (protected, limit 4); choroid plexus: 9.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TBC1D7,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000146047,True,compatible,family_exclusion,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,H2BC1,current_adaptive,False,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000146221,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333165,0.293197,0.0434783,0,80,unavailable,7.6,0.2,0.5,"cerebellum: 7.6 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TCTE1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000146243,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.6667% (minimum 75%, Missing); basal ganglia: 70.4918% (minimum 75%, Missing); bone marrow: 44.7917% (minimum 75%, Missing); cerebellum: 74.1379% (minimum 75%, Missing); cerebral cortex: 72.8814% (minimum 75%, Missing); choroid plexus: 69.3548% (minimum 75%, Missing); heart muscle: 72.8814% (minimum 75%, Missing); hypothalamus: 74.1379% (minimum 75%, Missing); kidney: 60.5634% (minimum 75%, Missing); lung: 67.1875% (minimum 75%, Missing); pancreas: 58.1081% (minimum 75%, Missing); parathyroid gland: 55.1282% (minimum 70%, Missing); pituitary gland: 56.5789% (minimum 75%, Missing); retina: 44.3299% (minimum 75%, Missing); salivary gland: 62.3188% (minimum 70%, Missing); smooth muscle: 68.2540% (minimum 75%, Missing); stomach: 56.5789% (minimum 70%, Missing); thymus: 59.7222% (minimum 65%, Missing); thyroid gland: 57.3333% (minimum 65%, Missing)",-0.0766667,-0.148718,-0.306701,0,80,unavailable,5.4,3.5,3.2,"retina: 5.4 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 3); stomach: 3.3 nTPM (protected, limit 3); pituitary gland: 3.3 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IRAK1BP1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000146263,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 48.5294% (minimum 75%, Missing); lymph node: 66.0000% (minimum 70%, Missing); retina: 74.1573% (minimum 75%, Missing); thymus: 56.4103% (minimum 65%, Missing)",-0.0858974,-0.04,-0.264706,0,80,unavailable,7,3.4,5.1,"bone marrow: 7 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); lymph node: 3.4 nTPM (protected, limit 3); retina: 2.3 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MMS22L,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000146276,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 3.6290% (minimum 75%, Missing)",0.25,0.2,-0.71371,0,80,unavailable,23.9,0.1,0.1,"retina: 23.9 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GABRR1,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000146378,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TAAR2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000146410,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 29.6943% (minimum 75%, Missing); duodenum: 71.5789% (minimum 75%, Missing); lymph node: 52.3077% (minimum 70%, Missing); rectum: 65.3846% (minimum 70%, Missing); thymus: 53.1250% (minimum 65%, Missing)",-0.11875,-0.176923,-0.453057,0,0,routine_complete,16.1,6.2,6,"bone marrow: 16.1 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 3); thymus: 6 nTPM (manageable, limit 5); rectum: 3.6 nTPM (protected, limit 3); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MTFR2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000146453,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 68.6957% (minimum 75%, Missing)",0.23764,0.251807,-0.0630435,0,1,partial,3.6,0.4,1,"basal ganglia: 3.6 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PNLDC1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000146670,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 41.1173% (minimum 75%, Missing); lymph node: 68.9139% (minimum 70%, Missing); thymus: 57.8616% (minimum 65%, Missing)",-0.0713836,-0.0108614,-0.338827,0,13,partial,52.7,16.6,26.8,"bone marrow: 52.7 nTPM (vital, limit 1); thymus: 26.8 nTPM (manageable, limit 5); lymph node: 16.6 nTPM (protected, limit 3); esophagus: 9.1 nTPM (protected, limit 3); rectum: 7.4 nTPM (protected, limit 3); colon: 6.6 nTPM (protected, limit 3); spleen: 6.4 nTPM (manageable, limit 5); small intestine: 5.7 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); cerebral cortex: 2.7 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: Medium (Enhanced); colon / goblet cells: Medium (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),88,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CDCA5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000146733,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 63.3466% (minimum 75%, Missing); amygdala: 60.2273% (minimum 75%, Missing); basal ganglia: 56.3830% (minimum 75%, Missing); cerebellum: 70.0441% (minimum 75%, Missing); cerebral cortex: 60.2273% (minimum 75%, Missing); choroid plexus: 55.0173% (minimum 75%, Missing); esophagus: 65.1639% (minimum 70%, Missing); heart muscle: 66.8067% (minimum 75%, Missing); hippocampal formation: 62.3529% (minimum 75%, Missing); hypothalamus: 62.8458% (minimum 75%, Missing); kidney: 62.1094% (minimum 75%, Missing); midbrain: 61.8677% (minimum 75%, Missing); pancreas: 70.9821% (minimum 75%, Missing); pituitary gland: 63.3466% (minimum 75%, Missing); spinal cord: 57.4007% (minimum 75%, Missing)",0.0504405,-0.0483607,-0.199827,0,4,partial,13,8.5,6.8,"choroid plexus: 13 nTPM (vital, limit 1); basal ganglia: 12.3 nTPM (vital, limit 1); spinal cord: 11.8 nTPM (vital, limit 1); amygdala: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.5 nTPM (vital, limit 1); midbrain: 9.8 nTPM (vital, limit 1); kidney: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.4 nTPM (vital, limit 1); adrenal gland: 9.2 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 3); heart muscle: 7.9 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 2); parathyroid gland: 6.6 nTPM (protected, limit 3); pancreas: 6.5 nTPM (vital, limit 1); tongue: 6.4 nTPM (protected, limit 3); thymus: 6.3 nTPM (manageable, limit 5); stomach: 6 nTPM (protected, limit 3); lymph node: 5.1 nTPM (protected, limit 4); urinary bladder: 5 nTPM (protected, limit 3); smooth muscle: 4.9 nTPM (vital, limit 2); colon: 4.8 nTPM (protected, limit 3); skeletal muscle: 4.5 nTPM (vital, limit 2); salivary gland: 4.3 nTPM (protected, limit 3); rectum: 4.3 nTPM (protected, limit 3); retina: 4.2 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 2); lung: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); lung / macrophages: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PSPH,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000146839,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZAN,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000146859,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 44.2649% (minimum 65%, Missing); adrenal gland: 59.5652% (minimum 75%, Missing); bone marrow: 71.7277% (minimum 75%, Missing); colon: 62.2727% (minimum 70%, Missing); duodenum: 61.2975% (minimum 75%, Missing); heart muscle: 47.9860% (minimum 75%, Missing); hippocampal formation: 74.6594% (minimum 75%, Missing); kidney: 50.9294% (minimum 75%, Missing); liver: 34.5088% (minimum 75%, Missing); lung: 47.9021% (minimum 75%, Missing); lymph node: 58.1741% (minimum 70%, Missing); midbrain: 66.9927% (minimum 75%, Missing); pancreas: 65.5502% (minimum 75%, Missing); salivary gland: 61.7117% (minimum 70%, Missing); skeletal muscle: 24.4861% (minimum 75%, Missing); small intestine: 62.1315% (minimum 75%, Missing); smooth muscle: 73.0667% (minimum 75%, Missing); spinal cord: 53.6204% (minimum 75%, Missing); spleen: 50.2752% (minimum 65%, Missing); stomach: 69.1919% (minimum 70%, Missing); tongue: 57.6842% (minimum 70%, Missing); urinary bladder: 63.1336% (minimum 70%, Missing)",-0.207351,-0.123158,-0.505139,0,80,unavailable,84.5,20.1,34.5,"skeletal muscle: 84.5 nTPM (vital, limit 1); liver: 52 nTPM (vital, limit 1); adipose tissue: 34.5 nTPM (manageable, limit 5); lung: 29.8 nTPM (vital, limit 1); heart muscle: 29.7 nTPM (vital, limit 1); spleen: 27.1 nTPM (manageable, limit 5); kidney: 26.4 nTPM (vital, limit 1); spinal cord: 23.7 nTPM (vital, limit 1); tongue: 20.1 nTPM (protected, limit 3); lymph node: 19.7 nTPM (protected, limit 3); adrenal gland: 18.6 nTPM (vital, limit 1); duodenum: 17.3 nTPM (vital, limit 1); salivary gland: 17 nTPM (protected, limit 3); small intestine: 16.7 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 3); urinary bladder: 16 nTPM (protected, limit 3); pancreas: 14.4 nTPM (vital, limit 1); midbrain: 13.5 nTPM (vital, limit 1); stomach: 12.2 nTPM (protected, limit 3); bone marrow: 10.8 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (manageable, limit 5); smooth muscle: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); skin: 8.9 nTPM (manageable, limit 5); basal ganglia: 8.9 nTPM (vital, limit 1); esophagus: 8.9 nTPM (protected, limit 3); rectum: 8.1 nTPM (protected, limit 3); cerebral cortex: 8 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); choroid plexus: 5.5 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TMEM140,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000146918,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 37.4026% (minimum 75%, Missing); colon: 68.2464% (minimum 70%, Missing); esophagus: 68.2464% (minimum 70%, Missing); lymph node: 54.3396% (minimum 70%, Missing); rectum: 66.0550% (minimum 70%, Missing); small intestine: 72.0000% (minimum 75%, Missing); thymus: 34.6154% (minimum 65%, Missing)",-0.303846,-0.156604,-0.375974,0,1,partial,24.1,12.1,27.2,"thymus: 27.2 nTPM (manageable, limit 5); bone marrow: 24.1 nTPM (vital, limit 1); lymph node: 12.1 nTPM (protected, limit 3); rectum: 7.4 nTPM (protected, limit 3); colon: 6.7 nTPM (protected, limit 3); esophagus: 6.7 nTPM (protected, limit 3); skin: 6.6 nTPM (manageable, limit 5); small intestine: 5.6 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); smooth muscle: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.5 nTPM (protected, limit 3); duodenum: 4.3 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 3); urinary bladder: 3.9 nTPM (protected, limit 3); pituitary gland: 3.4 nTPM (vital, limit 1); salivary gland: 3.4 nTPM (protected, limit 3); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NCAPG2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000147081,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AKAP4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000147082,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"spinal cord: 69.5122% (minimum 75%, Missing)",0.3,0.234426,-0.054878,0,80,unavailable,2.5,0.4,0.3,"spinal cord: 2.5 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCNB3,current_adaptive,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · preferential,False,False,False,False,False,unchanged,
ENSG00000147127,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 70.9091% (minimum 75%, Missing); cerebral cortex: 73.5849% (minimum 75%, Missing); midbrain: 72.2222% (minimum 75%, Missing); retina: 6.5109% (minimum 75%, Missing)",0.278571,0.228571,-0.684891,0,80,unavailable,56,0.3,0.3,"retina: 56 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RAB41,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000147180,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.1198% (minimum 75%, Missing); cerebral cortex: 66.4220% (minimum 75%, Missing)",0.0448177,0.211839,-0.0857798,0,6,partial,18.3,4,15.9,"cerebral cortex: 18.3 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); adrenal gland: 14.7 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); pituitary gland: 10.6 nTPM (vital, limit 1); hypothalamus: 9 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); bone marrow: 7.1 nTPM (vital, limit 6); midbrain: 7 nTPM (vital, limit 1); spinal cord: 7 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); colon: 3.5 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF711,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000147183,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CPXCR1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000147206,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.221311,0,2,partial,4.8,1,0.6,"lung: 4.8 nTPM (vital, limit 2); bone marrow: 3.9 nTPM (vital, limit 2); small intestine: 2.9 nTPM (vital, limit 2)",duodenum / glandular cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,NXF3,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000147316,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5862% (minimum 65%, Missing); adrenal gland: 62.8866% (minimum 75%, Missing); amygdala: 62.8866% (minimum 75%, Missing); basal ganglia: 61.0000% (minimum 75%, Missing); bone marrow: 31.7708% (minimum 75%, Missing); cerebellum: 55.9633% (minimum 75%, Missing); cerebral cortex: 58.0952% (minimum 75%, Missing); choroid plexus: 67.7778% (minimum 75%, Missing); colon: 55.9633% (minimum 70%, Missing); duodenum: 61.6162% (minimum 75%, Missing); esophagus: 57.0093% (minimum 70%, Missing); heart muscle: 59.8039% (minimum 75%, Missing); hippocampal formation: 61.6162% (minimum 75%, Missing); hypothalamus: 64.2105% (minimum 75%, Missing); kidney: 59.2233% (minimum 75%, Missing); liver: 61.6162% (minimum 75%, Missing); lung: 58.6538% (minimum 75%, Missing); lymph node: 53.9823% (minimum 70%, Missing); midbrain: 61.0000% (minimum 75%, Missing); pancreas: 54.9550% (minimum 75%, Missing); parathyroid gland: 60.3960% (minimum 70%, Missing); pituitary gland: 62.2449% (minimum 75%, Missing); rectum: 67.0330% (minimum 70%, Missing); retina: 58.0952% (minimum 75%, Missing); salivary gland: 51.6949% (minimum 70%, Missing); skeletal muscle: 39.1026% (minimum 75%, Missing); skin: 54.9550% (minimum 65%, Missing); small intestine: 57.5472% (minimum 75%, Missing); smooth muscle: 68.5393% (minimum 75%, Missing); spinal cord: 57.0093% (minimum 75%, Missing); spleen: 55.4545% (minimum 65%, Missing); stomach: 57.5472% (minimum 70%, Missing); thymus: 27.3543% (minimum 65%, Missing); thyroid gland: 57.5472% (minimum 65%, Missing); tongue: 62.2449% (minimum 70%, Missing); urinary bladder: 53.9823% (minimum 70%, Missing)",-0.376457,-0.183051,-0.432292,0,4,partial,13.1,5.7,16.2,"thymus: 16.2 nTPM (manageable, limit 5); bone marrow: 13.1 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); salivary gland: 5.7 nTPM (protected, limit 3); adipose tissue: 5.5 nTPM (manageable, limit 5); lymph node: 5.2 nTPM (protected, limit 3); urinary bladder: 5.2 nTPM (protected, limit 3); pancreas: 5 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 3); esophagus: 4.6 nTPM (protected, limit 3); spinal cord: 4.6 nTPM (vital, limit 1); stomach: 4.5 nTPM (protected, limit 3); small intestine: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); lung: 4.3 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 3); midbrain: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 3); adrenal gland: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type II: Medium (Supported); lung / endothelial cells: Medium (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 2 / epidermal cells: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 2 / fibroblasts: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MCPH1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000147378,True,compatible,,True,True,True,,0.340618,0.29871,0.247852,0,2,partial,0.9,0.3,2.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FATE1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000147381,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0.6,0.1,,,55,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEA4,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000147536,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 32.9412% (minimum 75%, Missing); colon: 58.3333% (minimum 70%, Missing); duodenum: 65.1163% (minimum 75%, Missing); esophagus: 63.6364% (minimum 70%, Missing); liver: 68.2927% (minimum 75%, Missing); lymph node: 35.8974% (minimum 70%, Missing); rectum: 49.1228% (minimum 70%, Missing); skin: 58.3333% (minimum 65%, Missing); small intestine: 63.6364% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 73.6842% (minimum 75%, Missing); spleen: 63.6364% (minimum 65%, Missing); thymus: 31.8182% (minimum 65%, Missing)",-0.331818,-0.341026,-0.420588,0,1,partial,5.7,5,6,"thymus: 6 nTPM (manageable, limit 5); bone marrow: 5.7 nTPM (vital, limit 1); lymph node: 5 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GINS4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000147570,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328462,0.194515,0.165108,0,80,unavailable,5.9,7.5,1.4,"lymph node: 7.5 nTPM (protected, limit 3); lung: 5.9 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); liver: 1.6 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAJC5B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000147571,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 52.5000% (minimum 75%, Missing); basal ganglia: 64.9485% (minimum 75%, Missing); cerebral cortex: 35.3933% (minimum 75%, Missing); hippocampal formation: 61.7647% (minimum 75%, Missing); hypothalamus: 12.0459% (minimum 75%, Missing)",0.157692,0.213043,-0.629541,0,80,unavailable,46,0.6,1.5,"hypothalamus: 46 nTPM (vital, limit 1); cerebral cortex: 11.5 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CRH,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000147596,True,compatible,,True,True,True,,0.225,0.3,0.0277778,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRDM14,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000147613,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"kidney: 33.3333% (minimum 75%, Missing); retina: 4.0000% (minimum 75%, Missing)",0.35,0.3,-0.71,0,5,partial,2.4,0,0,"retina: 2.4 nTPM (vital, limit 1)",cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); lung / macrophages: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved),51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PSKH2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000147874,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 58.1047% (minimum 75%, Missing); lymph node: 67.7326% (minimum 70%, Missing); retina: 72.8125% (minimum 75%, Missing); thymus: 61.3158% (minimum 65%, Missing)",-0.0368421,-0.0226744,-0.168953,0,4,partial,16.8,11.1,14.7,"bone marrow: 16.8 nTPM (vital, limit 1); thymus: 14.7 nTPM (manageable, limit 5); lymph node: 11.1 nTPM (protected, limit 3); retina: 8.7 nTPM (vital, limit 1); skin: 7.9 nTPM (manageable, limit 5); spinal cord: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.1 nTPM (vital, limit 1); tongue: 6.9 nTPM (protected, limit 3); smooth muscle: 6.9 nTPM (vital, limit 1); liver: 6.7 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); adrenal gland: 6.3 nTPM (vital, limit 1); rectum: 6 nTPM (protected, limit 3); urinary bladder: 5.9 nTPM (protected, limit 3); parathyroid gland: 5.9 nTPM (protected, limit 3); midbrain: 5.7 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 3); cerebellum: 5.2 nTPM (vital, limit 1); adipose tissue: 5.1 nTPM (manageable, limit 5); small intestine: 5.1 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); heart muscle: 5 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 3); hippocampal formation: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); salivary gland: 4.3 nTPM (protected, limit 3); skeletal muscle: 4.2 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 3); hypothalamus: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HAUS6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000147912,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 57.6923% (minimum 75%, Uncertain); amygdala: 72.4138% (minimum 75%, Missing); basal ganglia: 64.4172% (minimum 75%, Missing); cerebellum: 73.4266% (minimum 75%, Uncertain); cerebral cortex: 57.6923% (minimum 75%, Uncertain); colon: 59.3220% (minimum 70%, Missing); heart muscle: 73.4266% (minimum 75%, Uncertain); hippocampal formation: 66.0377% (minimum 75%, Missing); hypothalamus: 68.1818% (minimum 75%, Missing); kidney: 73.9437% (minimum 75%, Uncertain); lymph node: 66.0377% (minimum 70%, Uncertain); pancreas: 62.1302% (minimum 75%, Uncertain); pituitary gland: 39.6226% (minimum 75%, Missing); salivary gland: 55.8511% (minimum 70%, Uncertain); skeletal muscle: 26.7857% (minimum 75%, Uncertain); small intestine: 69.5364% (minimum 75%, Missing); spleen: 51.7241% (minimum 65%, Uncertain); thyroid gland: 58.6592% (minimum 65%, Uncertain); tongue: 43.9331% (minimum 70%, Missing)",-0.132759,-0.260669,-0.482143,0,3,partial,28.7,13.4,9.8,"skeletal muscle: 28.7 nTPM (vital, limit 1); pituitary gland: 16 nTPM (vital, limit 1); tongue: 13.4 nTPM (protected, limit 3); spleen: 9.8 nTPM (manageable, limit 5); salivary gland: 8.3 nTPM (protected, limit 3); adrenal gland: 7.7 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); thyroid gland: 7.4 nTPM (manageable, limit 5); colon: 7.2 nTPM (protected, limit 3); pancreas: 6.4 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 3); hippocampal formation: 5.4 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); small intestine: 4.6 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 3); liver: 3.5 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); esophagus: 3.1 nTPM (protected, limit 3); spinal cord: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FBXO10,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000148019,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 54.6468% (minimum 75%, Missing); cerebellum: 71.3592% (minimum 75%, Missing); retina: 62.0253% (minimum 75%, Missing); thymus: 56.7568% (minimum 65%, Missing)",-0.0824324,0.0101449,-0.203532,0,2,partial,12.2,6,11.2,"bone marrow: 12.2 nTPM (vital, limit 1); thymus: 11.2 nTPM (manageable, limit 5); retina: 9 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 3); cerebellum: 5.9 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 2); cerebral cortex: 4.5 nTPM (vital, limit 1); spinal cord: 4.5 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 4); hippocampal formation: 4.1 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); rectum: 3.8 nTPM (protected, limit 3); basal ganglia: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); esophagus: 3.4 nTPM (protected, limit 3); liver: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); lung: 3.2 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 3); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 2); adrenal gland: 2.8 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CEP78,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000148156,True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ACTL7B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000148200,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.160219,0.209836,0.0877358,0,80,unavailable,4.3,2.2,5.2,"thyroid gland: 5.2 nTPM (manageable, limit 5); bone marrow: 4.3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NR6A1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000148215,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR5C1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000148602,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 19.4175% (minimum 75%, Missing)",0.35,0.3,-0.555825,0,80,unavailable,24.9,0,0,"retina: 24.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRIT1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000148604,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 12.9032% (minimum 75%, Missing); basal ganglia: 10.8108% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing); cerebral cortex: 7.1429% (minimum 75%, Missing); choroid plexus: 2.3392% (minimum 75%, Missing); heart muscle: 61.5385% (minimum 75%, Missing); hippocampal formation: 30.7692% (minimum 75%, Missing); hypothalamus: 27.5862% (minimum 75%, Missing); midbrain: 20.0000% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 0.5900% (minimum 75%, Missing)",0.15,0.1,-0.7441,0,80,unavailable,134.8,0.2,0.2,"retina: 134.8 nTPM (vital, limit 1); choroid plexus: 33.4 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 1); basal ganglia: 6.6 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RGR,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000148680,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"parathyroid gland: 40.0943% (minimum 70%, Missing)",0.235417,-0.299057,0.0595238,0,3,partial,2,12.7,1.1,"parathyroid gland: 12.7 nTPM (protected, limit 3); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuronal projections: Medium (Approved); colon / glandular cells: Low (Approved); hypothalamus / neuronal cells: Medium (Approved); hypothalamus / neuronal projections: High (Approved); kidney / cells in glomeruli: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HTR7,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000148814,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.314567,0.205172,0.0777027,0,10,partial,15.3,7.7,6.2,"choroid plexus: 15.3 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); hippocampal formation: 14.1 nTPM (vital, limit 1); cerebral cortex: 13.6 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); hypothalamus: 12.1 nTPM (vital, limit 1); retina: 10.6 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); spinal cord: 8.2 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 3); kidney: 6.9 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 3); cerebellum: 4.5 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / peripheral nerve/ganglion: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRRC27,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000148832,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.19984,0.113456,0.0300587,0,80,unavailable,7.5,6.1,4.7,"liver: 7.5 nTPM (vital, limit 1); esophagus: 6.1 nTPM (protected, limit 3); small intestine: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PAOX,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000148848,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.339378,0.3,0.234894,0,3,partial,3.1,8.6,7.8,"basal ganglia: 2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ADAM12,current_adaptive,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000148950,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.7596% (minimum 75%, Missing); amygdala: 42.2125% (minimum 75%, Missing); basal ganglia: 39.3487% (minimum 75%, Missing); bone marrow: 72.5000% (minimum 75%, Missing); cerebellum: 39.4022% (minimum 75%, Missing); cerebral cortex: 44.8916% (minimum 75%, Missing); choroid plexus: 44.8223% (minimum 75%, Missing); heart muscle: 53.3088% (minimum 75%, Missing); hippocampal formation: 46.2520% (minimum 75%, Missing); hypothalamus: 49.4881% (minimum 75%, Missing); kidney: 52.3466% (minimum 75%, Missing); liver: 61.5711% (minimum 75%, Missing); midbrain: 52.5362% (minimum 75%, Missing); pancreas: 64.4444% (minimum 75%, Missing); parathyroid gland: 62.7706% (minimum 70%, Missing); pituitary gland: 56.0928% (minimum 75%, Missing); retina: 44.2748% (minimum 75%, Missing); skeletal muscle: 37.5162% (minimum 75%, Missing); smooth muscle: 73.7913% (minimum 75%, Missing); spinal cord: 56.2016% (minimum 75%, Missing); stomach: 66.3616% (minimum 70%, Missing); thymus: 54.6139% (minimum 65%, Missing); tongue: 41.4286% (minimum 70%, Missing)",-0.103861,-0.285714,-0.374838,0,5,partial,48.3,41,24.1,"skeletal muscle: 48.3 nTPM (vital, limit 1); basal ganglia: 44.7 nTPM (vital, limit 1); cerebellum: 44.6 nTPM (vital, limit 1); tongue: 41 nTPM (protected, limit 3); amygdala: 39.7 nTPM (vital, limit 1); retina: 36.5 nTPM (vital, limit 1); choroid plexus: 35.7 nTPM (vital, limit 1); cerebral cortex: 35.6 nTPM (vital, limit 1); hippocampal formation: 33.7 nTPM (vital, limit 1); hypothalamus: 29.6 nTPM (vital, limit 1); kidney: 26.4 nTPM (vital, limit 1); midbrain: 26.2 nTPM (vital, limit 1); heart muscle: 25.4 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); pituitary gland: 22.7 nTPM (vital, limit 1); spinal cord: 22.6 nTPM (vital, limit 1); liver: 18.1 nTPM (vital, limit 1); parathyroid gland: 17.2 nTPM (protected, limit 3); pancreas: 16 nTPM (vital, limit 1); adrenal gland: 15.1 nTPM (vital, limit 1); stomach: 14.7 nTPM (protected, limit 3); thyroid gland: 12.8 nTPM (manageable, limit 5); colon: 12.3 nTPM (protected, limit 3); skin: 12.1 nTPM (manageable, limit 5); esophagus: 11.4 nTPM (protected, limit 3); salivary gland: 11.4 nTPM (protected, limit 3); adipose tissue: 11.3 nTPM (manageable, limit 10); bone marrow: 11 nTPM (vital, limit 1); spleen: 10.6 nTPM (manageable, limit 5); urinary bladder: 10.5 nTPM (protected, limit 3); smooth muscle: 10.3 nTPM (vital, limit 1); rectum: 9.7 nTPM (protected, limit 3); lymph node: 9.3 nTPM (protected, limit 3); small intestine: 9.2 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); duodenum: 8.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IMMP1L,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000149050,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 74.0000% (minimum 75%, Missing); cerebral cortex: 72.5490% (minimum 75%, Missing); choroid plexus: 69.8113% (minimum 75%, Missing); kidney: 61.6667% (minimum 75%, Missing); parathyroid gland: 60.6557% (minimum 70%, Missing); pituitary gland: 74.0000% (minimum 75%, Missing); retina: 41.5730% (minimum 75%, Missing); smooth muscle: 68.5185% (minimum 75%, Missing); thyroid gland: 52.8571% (minimum 65%, Missing)",-0.121429,-0.0934426,-0.33427,0,80,unavailable,5.2,2.4,3.3,"retina: 5.2 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF214,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000149054,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 68.1818% (minimum 75%, Missing); colon: 42.8571% (minimum 55%, Enhanced); duodenum: 41.6667% (minimum 60%, Enhanced); hypothalamus: 71.4286% (minimum 75%, Missing); lymph node: 31.2500% (minimum 70%, Missing); pancreas: 40.5405% (minimum 75%, Missing); rectum: 37.5000% (minimum 55%, Enhanced); salivary gland: 53.5714% (minimum 55%, Enhanced); small intestine: 44.1176% (minimum 60%, Enhanced); spleen: 48.3871% (minimum 65%, Missing); thymus: 57.6923% (minimum 65%, Missing)",-0.166129,-0.3875,-0.344595,0,2,partial,2.2,3.3,1.6,"lymph node: 3.3 nTPM (protected, limit 3); pancreas: 2.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF215,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000149212,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 64.6313% (minimum 75%, Missing); cerebral cortex: 73.7188% (minimum 75%, Missing); parathyroid gland: 69.1739% (minimum 70%, Missing); retina: 71.1929% (minimum 75%, Missing)",0.0757439,-0.00826141,-0.103687,0,80,unavailable,30.7,25,21.2,"basal ganglia: 30.7 nTPM (vital, limit 1); parathyroid gland: 25 nTPM (protected, limit 3); lymph node: 23.8 nTPM (protected, limit 3); retina: 22.7 nTPM (vital, limit 1); thymus: 21.2 nTPM (manageable, limit 5); thyroid gland: 21.1 nTPM (manageable, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); amygdala: 18.2 nTPM (vital, limit 1); bone marrow: 17.7 nTPM (vital, limit 1); adrenal gland: 16.9 nTPM (vital, limit 1); spleen: 16.8 nTPM (manageable, limit 5); midbrain: 14.2 nTPM (vital, limit 1); hypothalamus: 13.5 nTPM (vital, limit 1); tongue: 12.7 nTPM (protected, limit 3); spinal cord: 12.2 nTPM (vital, limit 1); small intestine: 12.1 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 3); skin: 10.4 nTPM (manageable, limit 5); kidney: 10.1 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 3); choroid plexus: 9.6 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (manageable, limit 5); smooth muscle: 8.9 nTPM (vital, limit 1); lung: 8.8 nTPM (vital, limit 1); esophagus: 8.6 nTPM (protected, limit 3); liver: 7.3 nTPM (vital, limit 1); cerebellum: 7.1 nTPM (vital, limit 1); rectum: 6.3 nTPM (protected, limit 3); duodenum: 6.3 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 3); heart muscle: 5.2 nTPM (vital, limit 1); skeletal muscle: 5.1 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 3); pancreas: 3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SESN3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000149243,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 71.4286% (minimum 75%, Missing); basal ganglia: 46.3918% (minimum 75%, Missing); hippocampal formation: 70.8661% (minimum 75%, Missing); hypothalamus: 60.8108% (minimum 75%, Missing); spinal cord: 65.6934% (minimum 75%, Missing)",0.339011,0.278261,-0.286082,0,3,partial,10.4,1.1,1.1,"basal ganglia: 10.4 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KLHL35,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000149346,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.7692% (minimum 75%, Missing); amygdala: 70.7692% (minimum 75%, Missing); basal ganglia: 63.0137% (minimum 75%, Missing); bone marrow: 73.0159% (minimum 75%, Missing); cerebellum: 74.1935% (minimum 75%, Missing); cerebral cortex: 70.7692% (minimum 75%, Missing); colon: 69.6970% (minimum 70%, Missing); duodenum: 71.8750% (minimum 75%, Missing); esophagus: 63.8889% (minimum 70%, Missing); hippocampal formation: 69.6970% (minimum 75%, Missing); hypothalamus: 64.7887% (minimum 75%, Missing); kidney: 63.0137% (minimum 75%, Missing); liver: 59.7403% (minimum 75%, Missing); lymph node: 68.6567% (minimum 70%, Missing); midbrain: 67.6471% (minimum 75%, Missing); pancreas: 62.1622% (minimum 75%, Missing); parathyroid gland: 58.9744% (minimum 70%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); rectum: 67.6471% (minimum 70%, Missing); retina: 46.9388% (minimum 75%, Missing); skeletal muscle: 53.4884% (minimum 75%, Missing); skin: 56.0976% (minimum 65%, Missing); small intestine: 69.6970% (minimum 75%, Missing); spinal cord: 63.8889% (minimum 75%, Missing); stomach: 67.6471% (minimum 70%, Missing); thymus: 64.7887% (minimum 65%, Missing); thyroid gland: 63.8889% (minimum 65%, Missing)",-0.0890244,-0.110256,-0.280612,0,1,partial,5.2,3.2,3.6,"retina: 5.2 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLX4IP,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000149507,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / keratinocytes; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OOSP2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000149548,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.140698,0.0285714,0.0792683,0,80,unavailable,2.1,3.8,2.7,"salivary gland: 3.8 nTPM (protected, limit 3); bone marrow: 2.1 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC15,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000149554,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 53.0686% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); parathyroid gland: 69.6682% (minimum 70%, Missing); thymus: 59.0361% (minimum 65%, Missing)",-0.0596386,-0.0333333,-0.219314,0,80,unavailable,26,14.7,20.4,"bone marrow: 26 nTPM (vital, limit 1); thymus: 20.4 nTPM (manageable, limit 5); lymph node: 14.7 nTPM (protected, limit 3); parathyroid gland: 12.8 nTPM (protected, limit 3); rectum: 8.6 nTPM (protected, limit 3); colon: 8 nTPM (protected, limit 3); small intestine: 7.3 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 3); urinary bladder: 3.3 nTPM (protected, limit 3); smooth muscle: 3.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CHEK1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000149609,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C20orf144,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000149646,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 74.3363% (minimum 75%, Missing); retina: 62.2222% (minimum 75%, Missing); skeletal muscle: 52.3909% (minimum 75%, Missing); tongue: 61.0169% (minimum 70%, Missing)",0.168182,-0.0898305,-0.226091,0,6,partial,22.9,16.1,5.6,"skeletal muscle: 22.9 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 3); retina: 15.3 nTPM (vital, limit 1); bone marrow: 8.7 nTPM (vital, limit 1); cerebellum: 8.4 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); pancreas: 6.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); skin: 5.6 nTPM (manageable, limit 5); parathyroid gland: 5.5 nTPM (protected, limit 3); liver: 5.4 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); colon: 4.1 nTPM (protected, limit 3); amygdala: 4 nTPM (vital, limit 1); salivary gland: 4 nTPM (protected, limit 3); lymph node: 4 nTPM (protected, limit 3); hippocampal formation: 3.9 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CNBD2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000149651,False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.246338,0,2,partial,1,0,0,,adrenal gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland / glandular cells; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / non-germinal center cells,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,SPINT4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000149679,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 68.6364% (minimum 75%, Missing); heart muscle: 74.7525% (minimum 75%, Missing)",0.203107,0.160399,-0.0636364,0,80,unavailable,13.8,4.9,5.2,"cerebellum: 13.8 nTPM (vital, limit 1); heart muscle: 10.2 nTPM (vital, limit 1); cerebral cortex: 8.6 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); skeletal muscle: 5.6 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); hypothalamus: 5.1 nTPM (vital, limit 1); lymph node: 4.9 nTPM (protected, limit 3); small intestine: 4.3 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 3); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); tongue: 3.9 nTPM (protected, limit 3); basal ganglia: 3.9 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); midbrain: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 3); urinary bladder: 3.6 nTPM (protected, limit 3); spinal cord: 3.5 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); smooth muscle: 3.2 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); pancreas: 3.1 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 3); adrenal gland: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CABLES2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000149926,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 54.4629% (minimum 75%, Missing); cerebral cortex: 70.8131% (minimum 75%, Missing); retina: 60.7633% (minimum 75%, Missing)",0.33932,0.284541,-0.205371,0,80,unavailable,85.2,1.6,1.1,"cerebellum: 85.2 nTPM (vital, limit 1); retina: 65.8 nTPM (vital, limit 1); cerebral cortex: 42 nTPM (vital, limit 1); hippocampal formation: 30.7 nTPM (vital, limit 1); amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 21.8 nTPM (vital, limit 1); pituitary gland: 20.9 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); midbrain: 15.8 nTPM (vital, limit 1); skeletal muscle: 11.1 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TLCD3B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000149948,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 43.5294% (minimum 75%, Missing); colon: 64.9123% (minimum 70%, Missing); duodenum: 74.0000% (minimum 75%, Missing); rectum: 61.6667% (minimum 70%, Missing); skeletal muscle: 69.8113% (minimum 75%, Missing)",0.210465,-0.0833333,-0.314706,0,4,partial,4.8,2.3,0.6,"bone marrow: 4.8 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HMGA2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000150244,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRIM48,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000150275,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 14.8148% (minimum 75%, Missing); amygdala: 32.0000% (minimum 75%, Missing); basal ganglia: 47.7612% (minimum 75%, Missing); cerebral cortex: 32.6531% (minimum 75%, Missing); hippocampal formation: 35.1648% (minimum 75%, Missing); hypothalamus: 38.5542% (minimum 75%, Missing); kidney: 29.3578% (minimum 75%, Missing); lung: 57.1429% (minimum 75%, Missing); midbrain: 38.5542% (minimum 75%, Missing); pituitary gland: 41.0256% (minimum 75%, Missing); retina: 5.0713% (minimum 75%, Missing); spinal cord: 53.3333% (minimum 75%, Missing)",0.170513,0.164865,-0.699287,0,80,unavailable,59.9,0.5,0.7,"retina: 59.9 nTPM (vital, limit 1); adrenal gland: 18.4 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); midbrain: 5.1 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDH15,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000150455,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.6330% (minimum 65%, Missing); adrenal gland: 60.1852% (minimum 75%, Missing); cerebellum: 71.4286% (minimum 75%, Missing); cerebral cortex: 69.8925% (minimum 75%, Missing); choroid plexus: 63.7255% (minimum 75%, Missing); colon: 54.1667% (minimum 70%, Missing); duodenum: 45.7746% (minimum 75%, Missing); esophagus: 57.5221% (minimum 70%, Missing); heart muscle: 51.1811% (minimum 75%, Missing); hypothalamus: 73.0337% (minimum 75%, Missing); kidney: 61.9048% (minimum 75%, Missing); liver: 49.6183% (minimum 75%, Missing); lung: 63.1068% (minimum 75%, Missing); lymph node: 63.1068% (minimum 70%, Missing); midbrain: 73.0337% (minimum 75%, Missing); pancreas: 51.5873% (minimum 75%, Missing); parathyroid gland: 49.6183% (minimum 70%, Missing); pituitary gland: 65.0000% (minimum 75%, Missing); rectum: 54.1667% (minimum 70%, Missing); retina: 68.4211% (minimum 75%, Missing); salivary gland: 44.8276% (minimum 70%, Missing); skeletal muscle: 58.0357% (minimum 75%, Missing); skin: 61.9048% (minimum 65%, Missing); small intestine: 45.1389% (minimum 75%, Missing); smooth muscle: 58.0357% (minimum 75%, Missing); spleen: 58.5586% (minimum 65%, Missing); stomach: 63.1068% (minimum 70%, Missing); thyroid gland: 56.0345% (minimum 65%, Missing); tongue: 57.0175% (minimum 70%, Missing); urinary bladder: 59.6330% (minimum 70%, Missing)",-0.0896552,-0.251724,-0.298611,0,80,unavailable,7.9,8,5.1,"salivary gland: 8 nTPM (protected, limit 3); small intestine: 7.9 nTPM (vital, limit 1); duodenum: 7.7 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 3); liver: 6.6 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); pancreas: 6.1 nTPM (vital, limit 1); colon: 5.5 nTPM (protected, limit 3); rectum: 5.5 nTPM (protected, limit 3); thyroid gland: 5.1 nTPM (manageable, limit 5); tongue: 4.9 nTPM (protected, limit 3); esophagus: 4.8 nTPM (protected, limit 3); smooth muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); urinary bladder: 4.4 nTPM (protected, limit 3); adrenal gland: 4.3 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); lymph node: 3.8 nTPM (protected, limit 3); choroid plexus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TIRAP,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000150477,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 72.2892% (minimum 75%, Missing); bone marrow: 45.6274% (minimum 75%, Missing); cerebral cortex: 65.2174% (minimum 75%, Missing); choroid plexus: 67.4157% (minimum 75%, Missing); duodenum: 71.4286% (minimum 75%, Missing); heart muscle: 71.4286% (minimum 75%, Missing); kidney: 70.5882% (minimum 75%, Missing); liver: 73.1707% (minimum 75%, Missing); lung: 69.3642% (minimum 75%, Missing); lymph node: 69.3642% (minimum 70%, Missing); retina: 36.9231% (minimum 75%, Missing); salivary gland: 64.1711% (minimum 70%, Missing); skeletal muscle: 63.1579% (minimum 75%, Missing); skin: 58.8235% (minimum 65%, Missing); small intestine: 68.5714% (minimum 75%, Missing); spinal cord: 73.6196% (minimum 75%, Missing); stomach: 69.3642% (minimum 70%, Missing)",-0.0617647,-0.0582888,-0.380769,0,3,partial,20.5,6.7,8.4,"retina: 20.5 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); skin: 8.4 nTPM (manageable, limit 5); skeletal muscle: 7 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 3); cerebral cortex: 6.4 nTPM (vital, limit 1); choroid plexus: 5.8 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 3); lung: 5.3 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 3); kidney: 5 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 3); pancreas: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); parathyroid gland: 3.7 nTPM (protected, limit 3); midbrain: 3.6 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); rectum: 3.3 nTPM (protected, limit 3); urinary bladder: 3.1 nTPM (protected, limit 3); amygdala: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KIAA1328,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000150527,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 60.0000% (minimum 75%, Missing); bone marrow: 62.3377% (minimum 75%, Missing); choroid plexus: 31.3725% (minimum 75%, Missing); colon: 56.4706% (minimum 70%, Missing); duodenum: 33.3333% (minimum 75%, Missing); esophagus: 59.4427% (minimum 70%, Missing); kidney: 34.2246% (minimum 75%, Missing); liver: 22.6682% (minimum 75%, Missing); lung: 72.1805% (minimum 75%, Missing); pancreas: 47.9401% (minimum 75%, Missing); parathyroid gland: 50.8609% (minimum 70%, Missing); pituitary gland: 71.7757% (minimum 75%, Missing); rectum: 53.4819% (minimum 70%, Missing); salivary gland: 42.9530% (minimum 70%, Missing); skeletal muscle: 42.1978% (minimum 70%, Approved); small intestine: 33.9523% (minimum 75%, Missing); stomach: 46.8293% (minimum 70%, Missing); thyroid gland: 45.9330% (minimum 65%, Missing); tongue: 65.8662% (minimum 70%, Missing)",-0.19067,-0.27047,-0.523318,0,4,partial,131,51,45.2,"liver: 131 nTPM (vital, limit 1); choroid plexus: 84 nTPM (vital, limit 1); duodenum: 76.8 nTPM (vital, limit 1); small intestine: 74.7 nTPM (vital, limit 1); kidney: 73.8 nTPM (vital, limit 1); skeletal muscle: 52.6 nTPM (vital, limit 2); salivary gland: 51 nTPM (protected, limit 3); thyroid gland: 45.2 nTPM (manageable, limit 5); stomach: 43.6 nTPM (protected, limit 3); pancreas: 41.7 nTPM (vital, limit 1); parathyroid gland: 37.1 nTPM (protected, limit 3); rectum: 33.4 nTPM (protected, limit 3); colon: 29.6 nTPM (protected, limit 3); esophagus: 26.2 nTPM (protected, limit 3); adrenal gland: 25.6 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); tongue: 19.9 nTPM (protected, limit 3); heart muscle: 15.9 nTPM (vital, limit 2); lymph node: 15.8 nTPM (protected, limit 3); urinary bladder: 15.6 nTPM (protected, limit 3); pituitary gland: 15.1 nTPM (vital, limit 1); lung: 14.8 nTPM (vital, limit 1); spleen: 14.1 nTPM (manageable, limit 5); thymus: 13.9 nTPM (manageable, limit 5); retina: 12.4 nTPM (vital, limit 1); smooth muscle: 11.9 nTPM (vital, limit 1); adipose tissue: 11.7 nTPM (manageable, limit 10); skin: 9.6 nTPM (manageable, limit 5); cerebral cortex: 9.1 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 6.5 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MIA2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000150628,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.297054,0.234012,0,3,partial,2.2,0.4,1.6,"retina: 2.2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000150667,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 49.6454% (minimum 70%, Missing); rectum: 39.7727% (minimum 70%, Missing)",0.193373,-0.302273,0.0277778,0,80,unavailable,2,10.6,1.3,"rectum: 10.6 nTPM (protected, limit 3); colon: 7.1 nTPM (protected, limit 3); choroid plexus: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FSIP1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000150676,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC83,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000150760,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9361% (minimum 65%, Missing); amygdala: 42.6829% (minimum 75%, Missing); basal ganglia: 44.1441% (minimum 75%, Missing); cerebral cortex: 55.8087% (minimum 75%, Missing); choroid plexus: 70.6052% (minimum 75%, Missing); colon: 58.8942% (minimum 70%, Missing); duodenum: 65.3333% (minimum 75%, Missing); esophagus: 60.9453% (minimum 70%, Missing); heart muscle: 64.1361% (minimum 75%, Missing); hippocampal formation: 46.0526% (minimum 75%, Missing); hypothalamus: 53.0303% (minimum 75%, Missing); kidney: 56.8445% (minimum 75%, Missing); liver: 72.4852% (minimum 75%, Missing); lung: 64.8148% (minimum 75%, Missing); midbrain: 40.8333% (minimum 75%, Missing); pancreas: 64.1361% (minimum 75%, Missing); parathyroid gland: 49.7967% (minimum 70%, Missing); rectum: 64.6438% (minimum 65%, Approved); salivary gland: 58.7530% (minimum 70%, Missing); skin: 42.9825% (minimum 65%, Missing); small intestine: 62.6598% (minimum 75%, Missing); smooth muscle: 56.9767% (minimum 75%, Missing); spinal cord: 45.2030% (minimum 75%, Missing); stomach: 65.5080% (minimum 70%, Missing); thyroid gland: 48.7078% (minimum 65%, Missing); urinary bladder: 60.6436% (minimum 70%, Missing)",-0.220175,-0.202033,-0.341667,0,7,partial,35.5,24.7,32.5,"midbrain: 35.5 nTPM (vital, limit 1); amygdala: 32.9 nTPM (vital, limit 1); skin: 32.5 nTPM (manageable, limit 5); basal ganglia: 31 nTPM (vital, limit 1); spinal cord: 29.7 nTPM (vital, limit 1); hippocampal formation: 28.7 nTPM (vital, limit 1); thyroid gland: 25.8 nTPM (manageable, limit 5); parathyroid gland: 24.7 nTPM (protected, limit 3); hypothalamus: 21.7 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); adipose tissue: 19.3 nTPM (manageable, limit 5); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); salivary gland: 17.2 nTPM (protected, limit 3); colon: 17.1 nTPM (protected, limit 3); urinary bladder: 15.9 nTPM (protected, limit 3); esophagus: 15.7 nTPM (protected, limit 3); small intestine: 14.6 nTPM (vital, limit 1); heart muscle: 13.7 nTPM (vital, limit 1); pancreas: 13.7 nTPM (vital, limit 1); rectum: 13.4 nTPM (protected, limit 4); lung: 13.3 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 3); choroid plexus: 10.2 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 3); spleen: 9.7 nTPM (manageable, limit 5); liver: 9.3 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); adrenal gland: 7.9 nTPM (vital, limit 2); cerebellum: 5.8 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 2); lymph node: 4.5 nTPM (protected, limit 4); retina: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DOCK1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000150773,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.275395,0.241606,0.0931373,0,80,unavailable,12,4,5.2,"retina: 12 nTPM (vital, limit 1); choroid plexus: 9.3 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); parathyroid gland: 4 nTPM (protected, limit 3); kidney: 3.7 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PIH1D2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000150776,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.1045% (minimum 65%, Missing); adrenal gland: 64.2857% (minimum 75%, Missing); amygdala: 60.1824% (minimum 75%, Missing); basal ganglia: 62.4606% (minimum 75%, Missing); bone marrow: 60.7362% (minimum 75%, Missing); cerebellum: 47.4820% (minimum 75%, Missing); cerebral cortex: 58.4071% (minimum 75%, Missing); choroid plexus: 72.2628% (minimum 75%, Missing); colon: 62.6582% (minimum 70%, Missing); duodenum: 64.2857% (minimum 75%, Missing); esophagus: 59.6386% (minimum 65%, Approved); heart muscle: 61.1111% (minimum 70%, Approved); hippocampal formation: 60.5505% (minimum 75%, Missing); hypothalamus: 58.7537% (minimum 75%, Missing); kidney: 58.4071% (minimum 75%, Missing); liver: 63.4615% (minimum 75%, Missing); lung: 64.9180% (minimum 75%, Missing); lymph node: 58.9286% (minimum 70%, Missing); midbrain: 59.4595% (minimum 75%, Missing); pancreas: 62.4606% (minimum 75%, Missing); parathyroid gland: 59.2814% (minimum 65%, Approved); pituitary gland: 72.5275% (minimum 75%, Missing); rectum: 63.6656% (minimum 70%, Missing); retina: 37.9310% (minimum 75%, Missing); salivary gland: 59.8187% (minimum 70%, Missing); skeletal muscle: 52.5199% (minimum 70%, Approved); skin: 62.6582% (minimum 65%, Missing); small intestine: 64.7059% (minimum 75%, Missing); smooth muscle: 62.2642% (minimum 70%, Approved); spinal cord: 59.2814% (minimum 75%, Missing); stomach: 63.8710% (minimum 70%, Missing); thymus: 54.5455% (minimum 65%, Missing); thyroid gland: 56.0907% (minimum 65%, Missing); tongue: 67.1186% (minimum 70%, Missing); urinary bladder: 64.0777% (minimum 70%, Missing)",-0.104545,-0.110714,-0.37069,0,5,partial,32.4,13.8,16.5,"retina: 32.4 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); skeletal muscle: 17.9 nTPM (vital, limit 2); thymus: 16.5 nTPM (manageable, limit 5); thyroid gland: 15.5 nTPM (manageable, limit 5); cerebral cortex: 14.1 nTPM (vital, limit 1); kidney: 14.1 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); lymph node: 13.8 nTPM (protected, limit 3); adipose tissue: 13.7 nTPM (manageable, limit 5); spinal cord: 13.6 nTPM (vital, limit 1); parathyroid gland: 13.6 nTPM (protected, limit 4); midbrain: 13.5 nTPM (vital, limit 1); esophagus: 13.4 nTPM (protected, limit 4); salivary gland: 13.3 nTPM (protected, limit 3); amygdala: 13.1 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 2); spleen: 12.3 nTPM (manageable, limit 10); smooth muscle: 12 nTPM (vital, limit 2); pancreas: 11.9 nTPM (vital, limit 1); basal ganglia: 11.9 nTPM (vital, limit 1); skin: 11.8 nTPM (manageable, limit 5); colon: 11.8 nTPM (protected, limit 3); liver: 11.4 nTPM (vital, limit 1); rectum: 11.3 nTPM (protected, limit 3); stomach: 11.2 nTPM (protected, limit 3); urinary bladder: 11.1 nTPM (protected, limit 3); adrenal gland: 11 nTPM (vital, limit 1); duodenum: 11 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 1); lung: 10.7 nTPM (vital, limit 1); tongue: 9.7 nTPM (protected, limit 3); choroid plexus: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NKAPD1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000150783,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 70.5263% (minimum 75%, Missing)",0.34505,0.266346,-0.0447368,0,1,partial,8.4,0.7,0.7,"retina: 8.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX12,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000151005,True,compatible,,True,True,True,,0.348221,0.3,0.248221,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TKTL2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000151033,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LYZL2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000151062,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Missing); adrenal gland: 75.0000% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); bone marrow: 50.0000% (minimum 75%, Missing); cerebral cortex: 75.0000% (minimum 75%, Missing); choroid plexus: 75.0000% (minimum 75%, Missing); duodenum: 50.0000% (minimum 75%, Missing); hippocampal formation: 75.0000% (minimum 75%, Missing); lung: 60.0000% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); midbrain: 75.0000% (minimum 75%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 1.5152% (minimum 75%, Missing); small intestine: 75.0000% (minimum 75%, Missing); smooth muscle: 60.0000% (minimum 75%, Missing); spinal cord: 75.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); tongue: 42.8571% (minimum 70%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.15,-0.271429,-0.734848,0,80,unavailable,19.5,0.4,0.3,"retina: 19.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CACNA2D4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000151164,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.314912,0.256522,0.182203,0,1,partial,0.8,0.5,0.4,,skeletal muscle / myocytes: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RAD9B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000151247,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.3844% (minimum 65%, Missing); adrenal gland: 62.5773% (minimum 75%, Missing); amygdala: 70.3360% (minimum 75%, Missing); basal ganglia: 71.4959% (minimum 75%, Missing); bone marrow: 51.7477% (minimum 75%, Missing); cerebellum: 73.4867% (minimum 75%, Missing); cerebral cortex: 62.5129% (minimum 75%, Missing); choroid plexus: 66.4114% (minimum 75%, Missing); colon: 58.1975% (minimum 70%, Missing); duodenum: 63.4274% (minimum 75%, Missing); esophagus: 54.8329% (minimum 70%, Missing); heart muscle: 62.6419% (minimum 75%, Missing); hippocampal formation: 72.8691% (minimum 75%, Missing); hypothalamus: 66.7033% (minimum 75%, Missing); kidney: 57.0489% (minimum 75%, Missing); liver: 59.1042% (minimum 75%, Missing); lung: 69.8504% (minimum 75%, Missing); lymph node: 58.1975% (minimum 70%, Missing); midbrain: 67.4444% (minimum 75%, Missing); pancreas: 69.7701% (minimum 75%, Missing); parathyroid gland: 58.2534% (minimum 70%, Missing); rectum: 54.5373% (minimum 70%, Missing); retina: 53.6693% (minimum 75%, Missing); salivary gland: 66.7033% (minimum 70%, Missing); skeletal muscle: 61.6244% (minimum 75%, Missing); small intestine: 64.4374% (minimum 75%, Missing); smooth muscle: 61.5619% (minimum 75%, Missing); spinal cord: 62.9668% (minimum 75%, Missing); stomach: 63.4937% (minimum 70%, Missing); thymus: 53.9556% (minimum 65%, Missing); thyroid gland: 54.3420% (minimum 65%, Missing); tongue: 56.7290% (minimum 70%, Missing); urinary bladder: 53.6693% (minimum 70%, Missing)",-0.110444,-0.163307,-0.232523,0,9,partial,56.6,52.4,51.8,"bone marrow: 56.6 nTPM (vital, limit 1); urinary bladder: 52.4 nTPM (protected, limit 3); retina: 52.4 nTPM (vital, limit 1); thymus: 51.8 nTPM (manageable, limit 5); thyroid gland: 51 nTPM (manageable, limit 5); rectum: 50.6 nTPM (protected, limit 3); esophagus: 50 nTPM (protected, limit 3); tongue: 46.3 nTPM (protected, limit 3); kidney: 45.7 nTPM (vital, limit 1); colon: 43.6 nTPM (protected, limit 3); lymph node: 43.6 nTPM (protected, limit 3); parathyroid gland: 43.5 nTPM (protected, limit 3); liver: 42 nTPM (vital, limit 1); smooth muscle: 37.9 nTPM (vital, limit 1); skeletal muscle: 37.8 nTPM (vital, limit 1); adipose tissue: 36.6 nTPM (manageable, limit 5); cerebral cortex: 36.4 nTPM (vital, limit 1); adrenal gland: 36.3 nTPM (vital, limit 1); heart muscle: 36.2 nTPM (vital, limit 1); spinal cord: 35.7 nTPM (vital, limit 1); duodenum: 35 nTPM (vital, limit 1); stomach: 34.9 nTPM (protected, limit 3); small intestine: 33.5 nTPM (vital, limit 1); choroid plexus: 30.7 nTPM (vital, limit 1); spleen: 30.6 nTPM (manageable, limit 5); salivary gland: 30.3 nTPM (protected, limit 3); hypothalamus: 30.3 nTPM (vital, limit 1); midbrain: 29.3 nTPM (vital, limit 1); pancreas: 26.3 nTPM (vital, limit 1); lung: 26.2 nTPM (vital, limit 1); amygdala: 25.6 nTPM (vital, limit 1); basal ganglia: 24.2 nTPM (vital, limit 1); skin: 23.4 nTPM (manageable, limit 5); hippocampal formation: 22.6 nTPM (vital, limit 1); cerebellum: 21.9 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: Low (Supported); cerebellum / GLUC cells - cytoplasm/membrane: High (Supported); cerebellum / molecular layer cells - cytoplasm/membrane: High (Supported); cerebellum / Purkinje cells - cytoplasm/membrane: High (Supported); cerebellum / synaptic glomeruli - core: Low (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Low (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 1 / cells in basal layer: Medium (Supported); skin 1 / cells in granular layer: High (Supported); skin 1 / cells in spinous layer: Medium (Supported); skin 1 / eccrine glands: Medium (Supported); skin 1 / endothelial cells: Medium (Supported); skin 1 / fibrohistiocytic cells: High (Supported); skin 1 / langerhans cells: Medium (Supported); skin 1 / lymphocytes: Medium (Supported); skin 2 / cells in basal layer: Medium (Supported); skin 2 / cells in granular layer: Medium (Supported); skin 2 / cells in spinous layer: Medium (Supported); skin 2 / endothelial cells: Medium (Supported); skin 2 / fibrohistiocytic cells: High (Supported); skin 2 / langerhans cells: Medium (Supported); skin 2 / lymphocytes: High (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Low (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),89,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / eccrine glands; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EIF4E,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000151287,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.233617,0.211315,0.15443,0,8,partial,38.8,11.6,15.7,"liver: 38.8 nTPM (vital, limit 6); kidney: 18.5 nTPM (vital, limit 6); thymus: 15.7 nTPM (manageable, limit 5); bone marrow: 14.2 nTPM (vital, limit 6); lymph node: 11.6 nTPM (protected, limit 3); cerebellum: 10.8 nTPM (vital, limit 6); cerebral cortex: 9.9 nTPM (vital, limit 6); hypothalamus: 9.5 nTPM (vital, limit 1); skeletal muscle: 9.4 nTPM (vital, limit 6); tongue: 9 nTPM (protected, limit 3); heart muscle: 8.8 nTPM (vital, limit 6); amygdala: 8 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); spinal cord: 7.8 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); pituitary gland: 7 nTPM (vital, limit 1); smooth muscle: 7 nTPM (vital, limit 6); hippocampal formation: 6.5 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1)",skin 1 / cells in corneal layer: High (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced),68,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / cells in corneal layer; skin 2 / cells in corneal layer; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX30,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000151338,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.8739% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); pancreas: 66.1290% (minimum 75%, Missing); parathyroid gland: 55.0336% (minimum 70%, Missing); retina: 73.2143% (minimum 75%, Missing); smooth muscle: 71.3043% (minimum 75%, Missing); thyroid gland: 59.4203% (minimum 65%, Missing)",-0.0557971,-0.149664,-0.0887097,0,3,partial,4.2,6.7,5.6,"parathyroid gland: 6.7 nTPM (protected, limit 3); thyroid gland: 5.6 nTPM (manageable, limit 5); pancreas: 4.2 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); smooth muscle: 3.3 nTPM (vital, limit 1); urinary bladder: 3.2 nTPM (protected, limit 3); salivary gland: 3.1 nTPM (protected, limit 3); retina: 3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MIPOL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000151360,True,compatible,,True,True,True,,0.343789,0.3,0.213855,0,80,unavailable,0.6,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ALLC,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000151475,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.247826,0,0,routine_complete,0.1,0,0,,bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC25A31,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000151575,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 63.0435% (minimum 75%, Missing); duodenum: 68.2353% (minimum 75%, Missing); hypothalamus: 71.1656% (minimum 75%, Missing); kidney: 64.8045% (minimum 75%, Missing); parathyroid gland: 63.7363% (minimum 70%, Missing); pituitary gland: 56.3107% (minimum 75%, Missing); retina: 67.0520% (minimum 75%, Missing); salivary gland: 62.3656% (minimum 70%, Missing); stomach: 67.8363% (minimum 70%, Missing); thyroid gland: 59.7938% (minimum 65%, Missing)",-0.0520619,-0.0763441,-0.186893,0,80,unavailable,9,7,7.8,"pituitary gland: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); salivary gland: 7 nTPM (protected, limit 3); choroid plexus: 6.8 nTPM (vital, limit 1); parathyroid gland: 6.6 nTPM (protected, limit 3); kidney: 6.3 nTPM (vital, limit 1); retina: 5.7 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 3); duodenum: 5.4 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 3); adrenal gland: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX9,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000151577,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 15.7895% (minimum 75%, Missing)",0.35,0.3,-0.592105,0,80,unavailable,3.2,0,0,"basal ganglia: 3.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DRD3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000151615,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,POU4F2,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000151687,True,compatible,,True,True,True,,0.268033,0.203226,0.153226,0,80,unavailable,0.6,0.6,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ANKAR,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,True,True,True,True,gained,selectivity_revised
ENSG00000151725,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 31.6372% (minimum 75%, Missing); lymph node: 64.4144% (minimum 70%, Missing)",0.00747126,-0.0558559,-0.433628,0,80,unavailable,61.8,15.8,14.9,"bone marrow: 61.8 nTPM (vital, limit 1); lymph node: 15.8 nTPM (protected, limit 3); skin: 14.9 nTPM (manageable, limit 5); thymus: 12.5 nTPM (manageable, limit 5); esophagus: 10.1 nTPM (protected, limit 3); rectum: 7.8 nTPM (protected, limit 3); colon: 7.5 nTPM (protected, limit 3); small intestine: 5.2 nTPM (vital, limit 1); duodenum: 4.9 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 3); smooth muscle: 2.6 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CENPU,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000151773,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.4321% (minimum 75%, Missing); colon: 65.4321% (minimum 70%, Missing); heart muscle: 54.0816% (minimum 75%, Missing); hippocampal formation: 74.6479% (minimum 75%, Missing); kidney: 64.6341% (minimum 75%, Missing); liver: 69.7368% (minimum 75%, Missing); lung: 72.6027% (minimum 75%, Missing); lymph node: 66.2500% (minimum 70%, Missing); midbrain: 74.6479% (minimum 75%, Missing); pancreas: 60.2273% (minimum 70%, Approved); parathyroid gland: 57.6087% (minimum 65%, Approved); pituitary gland: 63.0952% (minimum 75%, Missing); rectum: 60.9195% (minimum 70%, Missing); salivary gland: 63.0952% (minimum 70%, Missing); skin: 57.6087% (minimum 65%, Missing); small intestine: 68.8312% (minimum 75%, Missing); smooth muscle: 62.3529% (minimum 75%, Missing); spinal cord: 73.6111% (minimum 75%, Missing); stomach: 63.8554% (minimum 70%, Missing); thyroid gland: 52.4752% (minimum 65%, Missing); urinary bladder: 65.4321% (minimum 70%, Missing)",-0.125248,-0.0908046,-0.209184,0,1,partial,4.5,3.9,4.8,"heart muscle: 4.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 2); rectum: 3.4 nTPM (protected, limit 3); smooth muscle: 3.2 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 3); pituitary gland: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC122,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000151789,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.5833% (minimum 65%, Missing); cerebellum: 46.2687% (minimum 75%, Missing); cerebral cortex: 62.0000% (minimum 75%, Missing); midbrain: 72.0930% (minimum 75%, Missing); retina: 43.9716% (minimum 75%, Missing); tongue: 63.9175% (minimum 70%, Missing); urinary bladder: 68.8889% (minimum 70%, Missing)",-0.00416667,-0.0608247,-0.310284,0,80,unavailable,7.9,3.5,3.4,"retina: 7.9 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF385D,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000151846,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.336188,0.278082,0.241667,0,4,partial,0.4,0.8,0.5,,bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PABPC3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000151962,True,compatible,,True,True,True,,0.335294,0.296283,0.246283,0,80,unavailable,0.1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RBM46,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000152086,False,excluded,rna_above_tissue_ceiling;family_exclusion,True,True,True,,0.35,0.3,0.0179135,0,80,unavailable,51.5,0,0,"heart muscle: 51.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TUBA3E,current_adaptive,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000152102,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 47.4641% (minimum 75%, Missing); basal ganglia: 41.7508% (minimum 75%, Missing); bone marrow: 52.0462% (minimum 60%, Enhanced); cerebellum: 43.7004% (minimum 75%, Missing); cerebral cortex: 42.1053% (minimum 75%, Missing); choroid plexus: 70.2550% (minimum 75%, Missing); colon: 48.6275% (minimum 55%, Enhanced); heart muscle: 54.1485% (minimum 75%, Missing); hippocampal formation: 47.5551% (minimum 75%, Missing); hypothalamus: 52.3759% (minimum 75%, Missing); kidney: 57.2088% (minimum 60%, Enhanced); lymph node: 64.6675% (minimum 70%, Missing); midbrain: 47.5551% (minimum 75%, Missing); parathyroid gland: 52.3207% (minimum 55%, Enhanced); pituitary gland: 71.4697% (minimum 75%, Missing); retina: 51.2927% (minimum 75%, Missing); skeletal muscle: 42.3932% (minimum 75%, Missing); small intestine: 59.7590% (minimum 60%, Enhanced); smooth muscle: 55.7303% (minimum 60%, Enhanced); spinal cord: 47.4641% (minimum 75%, Missing); stomach: 58.4906% (minimum 70%, Missing); thymus: 56.9460% (minimum 65%, Missing); thyroid gland: 58.5596% (minimum 65%, Missing); tongue: 49.3532% (minimum 70%, Missing); urinary bladder: 51.8286% (minimum 70%, Missing)",-0.0805396,-0.206468,-0.332492,0,2,partial,69.2,52.4,40,"basal ganglia: 69.2 nTPM (vital, limit 1); cerebral cortex: 68.2 nTPM (vital, limit 1); skeletal muscle: 67.4 nTPM (vital, limit 1); cerebellum: 63.9 nTPM (vital, limit 1); amygdala: 54.9 nTPM (vital, limit 1); spinal cord: 54.9 nTPM (vital, limit 1); midbrain: 54.7 nTPM (vital, limit 1); hippocampal formation: 54.7 nTPM (vital, limit 1); colon: 52.4 nTPM (protected, limit 12); tongue: 50.9 nTPM (protected, limit 3); retina: 47.1 nTPM (vital, limit 1); urinary bladder: 46.1 nTPM (protected, limit 3); bone marrow: 45.7 nTPM (vital, limit 6); parathyroid gland: 45.2 nTPM (protected, limit 12); hypothalamus: 45.1 nTPM (vital, limit 1); heart muscle: 42 nTPM (vital, limit 1); adipose tissue: 40 nTPM (manageable, limit 30); smooth muscle: 39.4 nTPM (vital, limit 6); thymus: 37.5 nTPM (manageable, limit 5); kidney: 37.1 nTPM (vital, limit 6); stomach: 35.2 nTPM (protected, limit 3); thyroid gland: 35.1 nTPM (manageable, limit 5); small intestine: 33.4 nTPM (vital, limit 6); esophagus: 33.3 nTPM (protected, limit 12); adrenal gland: 32.6 nTPM (vital, limit 6); rectum: 30.9 nTPM (protected, limit 12); liver: 30.1 nTPM (vital, limit 6); pancreas: 29.2 nTPM (vital, limit 6); salivary gland: 27.3 nTPM (protected, limit 12); lymph node: 27.1 nTPM (protected, limit 3); lung: 26.7 nTPM (vital, limit 6); duodenum: 25.6 nTPM (vital, limit 6); choroid plexus: 21 nTPM (vital, limit 1); pituitary gland: 19.8 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); skeletal muscle / myocytes: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM168B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000152192,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 26.4706% (minimum 75%, Missing); spinal cord: 64.2857% (minimum 75%, Missing); thymus: 56.2500% (minimum 65%, Missing)",-0.0875,0.0928571,-0.485294,0,1,partial,2.5,0.5,0.7,"retina: 2.5 nTPM (vital, limit 1)",retina / inner nuclear layer: Medium (Enhanced); retina / inner plexiform layer: High (Enhanced); retina / nerve fiber layer: High (Enhanced); retina / outer plexiform layer: High (Enhanced),63,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,POU4F1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000152208,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 74.6606% (minimum 75%, Missing)",0.35,0.296979,-0.00339367,0,5,partial,11.2,0.1,0,"cerebellum: 11.2 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced),70,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GRID2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000152253,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 75.0000% (minimum 75%, Missing); bone marrow: 45.8333% (minimum 75%, Missing); colon: 62.2642% (minimum 70%, Missing); duodenum: 50.7692% (minimum 75%, Missing); esophagus: 43.4211% (minimum 70%, Missing); kidney: 75.0000% (minimum 75%, Missing); lymph node: 45.8333% (minimum 70%, Missing); rectum: 68.7500% (minimum 70%, Missing); retina: 67.3469% (minimum 75%, Missing); small intestine: 62.2642% (minimum 75%, Missing); spleen: 61.1111% (minimum 65%, Missing); stomach: 67.3469% (minimum 70%, Missing); thymus: 28.2051% (minimum 65%, Missing)",-0.367949,-0.265789,-0.291667,0,2,partial,3.9,4.3,8.4,"thymus: 8.4 nTPM (manageable, limit 5); esophagus: 4.3 nTPM (protected, limit 3); bone marrow: 3.9 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 3); duodenum: 3.2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPC25,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000152315,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 67.6692% (minimum 75%, Missing); parathyroid gland: 60.8108% (minimum 65%, Approved)",0.233333,-0.0418919,-0.0733083,0,0,routine_complete,4.3,5.8,1.8,"parathyroid gland: 5.8 nTPM (protected, limit 4); choroid plexus: 4.3 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 2); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / glial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KCNK13,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000152348,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 66.2252% (minimum 75%, Missing); amygdala: 74.6269% (minimum 75%, Missing); bone marrow: 65.3595% (minimum 75%, Missing); cerebral cortex: 72.4638% (minimum 75%, Missing); choroid plexus: 62.8931% (minimum 75%, Missing); colon: 65.3595% (minimum 70%, Missing); esophagus: 67.5676% (minimum 70%, Missing); heart muscle: 69.4444% (minimum 75%, Missing); kidney: 64.9351% (minimum 75%, Missing); liver: 61.3497% (minimum 75%, Missing); lung: 73.5294% (minimum 75%, Missing); midbrain: 71.9424% (minimum 75%, Missing); pancreas: 69.9301% (minimum 75%, Missing); parathyroid gland: 47.1698% (minimum 65%, Approved); pituitary gland: 71.9424% (minimum 75%, Missing); rectum: 62.8931% (minimum 70%, Missing); retina: 74.6269% (minimum 75%, Missing); skeletal muscle: 59.1716% (minimum 75%, Missing); skin: 62.1118% (minimum 65%, Missing); smooth muscle: 65.3595% (minimum 75%, Missing); spinal cord: 69.4444% (minimum 75%, Missing); stomach: 68.9655% (minimum 70%, Missing); thymus: 56.8182% (minimum 65%, Missing); thyroid gland: 59.1716% (minimum 65%, Missing)",-0.0818182,-0.178302,-0.158284,0,3,partial,6.9,11.2,7.6,"parathyroid gland: 11.2 nTPM (protected, limit 4); thymus: 7.6 nTPM (manageable, limit 5); thyroid gland: 6.9 nTPM (manageable, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); skin: 6.1 nTPM (manageable, limit 5); rectum: 5.9 nTPM (protected, limit 3); choroid plexus: 5.9 nTPM (vital, limit 1); kidney: 5.4 nTPM (vital, limit 1); bone marrow: 5.3 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 3); smooth muscle: 5.3 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 3); stomach: 4.5 nTPM (protected, limit 3); spinal cord: 4.4 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); midbrain: 3.9 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 3); cerebral cortex: 3.8 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); lung: 3.6 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ATG10,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000152409,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 72.8814% (minimum 75%, Missing); basal ganglia: 71.6667% (minimum 75%, Missing); bone marrow: 55.8442% (minimum 75%, Missing); cerebellum: 62.9268% (minimum 75%, Missing); cerebral cortex: 67.1875% (minimum 75%, Missing); colon: 55.1282% (minimum 70%, Missing); heart muscle: 72.8814% (minimum 75%, Missing); kidney: 67.5393% (minimum 75%, Missing); liver: 71.6667% (minimum 75%, Missing); pancreas: 58.6364% (minimum 75%, Missing); parathyroid gland: 53.7500% (minimum 70%, Missing); pituitary gland: 73.2955% (minimum 75%, Missing); retina: 53.0864% (minimum 75%, Missing); salivary gland: 64.1791% (minimum 70%, Missing); skeletal muscle: 60.0000% (minimum 75%, Missing); smooth muscle: 64.8241% (minimum 75%, Missing); spinal cord: 72.8814% (minimum 75%, Missing); thyroid gland: 56.5789% (minimum 65%, Missing); tongue: 63.5468% (minimum 70%, Missing); urinary bladder: 68.9840% (minimum 70%, Missing)",-0.0842105,-0.1625,-0.219136,0,2,partial,11.4,11.1,9.9,"retina: 11.4 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 3); colon: 10.5 nTPM (protected, limit 3); bone marrow: 10.2 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (manageable, limit 5); pancreas: 9.1 nTPM (vital, limit 1); skeletal muscle: 8.6 nTPM (vital, limit 1); cerebellum: 7.6 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 3); salivary gland: 7.2 nTPM (protected, limit 3); smooth muscle: 7 nTPM (vital, limit 1); skin: 6.5 nTPM (manageable, limit 5); cerebral cortex: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); urinary bladder: 5.8 nTPM (protected, limit 3); thymus: 5.4 nTPM (manageable, limit 5); liver: 5.1 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); stomach: 5 nTPM (protected, limit 3); spinal cord: 4.8 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); esophagus: 4.8 nTPM (protected, limit 3); pituitary gland: 4.7 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); rectum: 4.2 nTPM (protected, limit 3); hippocampal formation: 4.2 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 3); lung: 3.8 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); choroid plexus: 3.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,JMY,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000152422,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 67.4603% (minimum 75%, Missing); amygdala: 70.2479% (minimum 75%, Missing); basal ganglia: 66.9291% (minimum 75%, Missing); bone marrow: 65.8915% (minimum 75%, Missing); cerebral cortex: 72.0339% (minimum 75%, Missing); colon: 59.8592% (minimum 70%, Missing); duodenum: 53.7975% (minimum 75%, Missing); esophagus: 69.6721% (minimum 70%, Missing); heart muscle: 52.4691% (minimum 75%, Missing); hippocampal formation: 68.5484% (minimum 75%, Missing); hypothalamus: 73.2759% (minimum 75%, Missing); kidney: 54.8387% (minimum 75%, Missing); liver: 61.5942% (minimum 65%, Supported); lung: 65.3846% (minimum 75%, Missing); lymph node: 50.5952% (minimum 70%, Missing); midbrain: 68.0000% (minimum 75%, Missing); rectum: 60.7143% (minimum 70%, Missing); small intestine: 62.9630% (minimum 75%, Missing); spinal cord: 68.0000% (minimum 75%, Missing); spleen: 64.3939% (minimum 65%, Missing); stomach: 66.9291% (minimum 70%, Missing); thymus: 45.9459% (minimum 65%, Missing); urinary bladder: 61.5942% (minimum 70%, Missing)",-0.190541,-0.194048,-0.225309,0,6,partial,7.7,8.3,10,"thymus: 10 nTPM (manageable, limit 5); lymph node: 8.3 nTPM (protected, limit 3); heart muscle: 7.7 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); kidney: 7 nTPM (vital, limit 1); colon: 5.7 nTPM (protected, limit 3); rectum: 5.5 nTPM (protected, limit 3); urinary bladder: 5.3 nTPM (protected, limit 3); liver: 5.3 nTPM (vital, limit 3); small intestine: 5 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); bone marrow: 4.4 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); stomach: 4.2 nTPM (protected, limit 3); adrenal gland: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 3); esophagus: 3.7 nTPM (protected, limit 3); amygdala: 3.6 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 3); cerebral cortex: 3.3 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); lung / alveolar cells type I: Medium (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Low (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,XRCC4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000152430,True,compatible,,True,True,True,,0.35,0.273361,0.25,0,1,partial,3.6,1.3,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BOLL,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,False,gained,selectivity_revised
ENSG00000152443,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 55.5263% (minimum 75%, Missing); cerebellum: 59.7734% (minimum 75%, Missing); kidney: 74.0351% (minimum 75%, Missing); parathyroid gland: 66.7722% (minimum 70%, Missing); pituitary gland: 72.5086% (minimum 75%, Missing); retina: 51.3382% (minimum 75%, Missing); skeletal muscle: 70.5686% (minimum 75%, Missing); thymus: 63.1737% (minimum 65%, Missing); tongue: 68.0645% (minimum 70%, Missing)",-0.0182635,-0.0322785,-0.236618,0,80,unavailable,20,10.5,12.3,"retina: 20 nTPM (vital, limit 1); bone marrow: 16.9 nTPM (vital, limit 1); cerebellum: 14.2 nTPM (vital, limit 1); thymus: 12.3 nTPM (manageable, limit 5); parathyroid gland: 10.5 nTPM (protected, limit 3); tongue: 9.9 nTPM (protected, limit 3); thyroid gland: 9 nTPM (manageable, limit 5); skeletal muscle: 8.8 nTPM (vital, limit 1); lymph node: 8.1 nTPM (protected, limit 3); pituitary gland: 8 nTPM (vital, limit 1); spleen: 7.9 nTPM (manageable, limit 5); salivary gland: 7.6 nTPM (protected, limit 3); kidney: 7.4 nTPM (vital, limit 1); stomach: 7.4 nTPM (protected, limit 3); heart muscle: 6.9 nTPM (vital, limit 1); liver: 6.6 nTPM (vital, limit 1); rectum: 6.5 nTPM (protected, limit 3); skin: 6.3 nTPM (manageable, limit 5); adrenal gland: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6.2 nTPM (protected, limit 3); lung: 6.1 nTPM (vital, limit 1); choroid plexus: 6 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); hypothalamus: 5.8 nTPM (vital, limit 1); small intestine: 5.8 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 3); midbrain: 5.1 nTPM (vital, limit 1); esophagus: 4.9 nTPM (protected, limit 3); pancreas: 4.5 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF776,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000152455,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.215909,0.269466,0.17029,0,1,partial,4.9,3.3,5.9,"thymus: 5.9 nTPM (manageable, limit 5); retina: 3.3 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SUV39H2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000152463,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.25,0.209408,0.2131,0,3,partial,1.7,2.9,8.7,,adrenal gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OLAH,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000152464,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 68.4751% (minimum 75%, Missing); choroid plexus: 73.3124% (minimum 75%, Missing); kidney: 73.6593% (minimum 75%, Missing); small intestine: 74.3631% (minimum 75%, Missing)",0.0865931,0.00437406,-0.0652493,0,3,partial,21.5,19.6,17.2,"cerebellum: 21.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 3); liver: 18.9 nTPM (vital, limit 2); skeletal muscle: 18.3 nTPM (vital, limit 2); spleen: 17.2 nTPM (manageable, limit 10); urinary bladder: 17 nTPM (protected, limit 3); choroid plexus: 17 nTPM (vital, limit 1); kidney: 16.7 nTPM (vital, limit 1); skin: 16.7 nTPM (manageable, limit 5); small intestine: 16.1 nTPM (vital, limit 1); rectum: 16.1 nTPM (protected, limit 3); esophagus: 15.8 nTPM (protected, limit 3); colon: 15.8 nTPM (protected, limit 3); thyroid gland: 15.7 nTPM (manageable, limit 10); duodenum: 15.4 nTPM (vital, limit 1); thymus: 15.3 nTPM (manageable, limit 5); stomach: 15 nTPM (protected, limit 3); pancreas: 14.8 nTPM (vital, limit 2); tongue: 14.3 nTPM (protected, limit 3); salivary gland: 14 nTPM (protected, limit 3); parathyroid gland: 13.8 nTPM (protected, limit 4); adipose tissue: 13.5 nTPM (manageable, limit 10); lung: 13.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 13 nTPM (vital, limit 1); heart muscle: 12.6 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 2); bone marrow: 12.3 nTPM (vital, limit 2); smooth muscle: 12 nTPM (vital, limit 2); basal ganglia: 11 nTPM (vital, limit 1); hypothalamus: 10.2 nTPM (vital, limit 1); spinal cord: 10.1 nTPM (vital, limit 1); cerebral cortex: 10.1 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.8 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RPP38,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000152495,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.0937% (minimum 75%, Missing); amygdala: 62.7586% (minimum 75%, Missing); basal ganglia: 34.7328% (minimum 75%, Missing); bone marrow: 74.5902% (minimum 75%, Missing); cerebellum: 14.5367% (minimum 75%, Missing); cerebral cortex: 47.8947% (minimum 75%, Missing); hippocampal formation: 64.5390% (minimum 75%, Missing); lymph node: 53.5294% (minimum 70%, Missing); retina: 66.4234% (minimum 75%, Missing); thymus: 14.4216% (minimum 65%, Missing)",-0.505784,-0.164706,-0.604633,0,1,partial,53.5,7.9,54,"thymus: 54 nTPM (manageable, limit 5); cerebellum: 53.5 nTPM (vital, limit 1); basal ganglia: 17.1 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 3); amygdala: 5.4 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CAMK4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000152503,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.34588,0.25864,0.0477369,0,80,unavailable,42.9,7.3,0.7,"retina: 42.9 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 1); choroid plexus: 14.4 nTPM (vital, limit 1); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 13.4 nTPM (vital, limit 1); hypothalamus: 13.1 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); rectum: 7.3 nTPM (protected, limit 3); colon: 7.2 nTPM (protected, limit 3); basal ganglia: 4.7 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRIM36,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000152582,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 45.2663% (minimum 75%, Missing); pituitary gland: 70.8333% (minimum 75%, Missing); retina: 60.7143% (minimum 75%, Missing)",0.14557,0.0983051,-0.297337,0,4,partial,18.5,8.3,8.4,"choroid plexus: 18.5 nTPM (vital, limit 1); retina: 9.9 nTPM (vital, limit 1); kidney: 7.4 nTPM (vital, limit 6); pituitary gland: 6.3 nTPM (vital, limit 1); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPEF2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000152592,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.188889,0.25,0,4,partial,0,0.1,0,,adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DMP1,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000152611,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 54.7777% (minimum 75%, Missing)",0.292832,0.3,-0.202223,0,5,partial,88.5,1.1,6.5,"choroid plexus: 88.5 nTPM (vital, limit 1); pituitary gland: 13.2 nTPM (vital, limit 1); hypothalamus: 7.4 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); hippocampal formation: 7.1 nTPM (vital, limit 1); thymus: 6.5 nTPM (manageable, limit 5); basal ganglia: 6.1 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CAPSL,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000152670,True,compatible,,True,True,True,,0.348624,0.3,0.247938,0,1,partial,0.4,0.2,0.2,,,55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DDX4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000152705,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.326271,0.244262,0.158517,0,80,unavailable,2.9,1.7,0.7,"skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CATSPER3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000152763,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 63.0996% (minimum 75%, Missing)",0.207143,0.136186,-0.119004,0,80,unavailable,20,6.7,5.7,"choroid plexus: 20 nTPM (vital, limit 1); parathyroid gland: 6.7 nTPM (protected, limit 3); kidney: 6.1 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); colon: 5.2 nTPM (protected, limit 3); lung: 4.1 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 3); retina: 3.9 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAI4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000153044,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 46.4516% (minimum 70%, Approved); lymph node: 62.4729% (minimum 70%, Missing); thymus: 61.5385% (minimum 65%, Missing)",-0.0346154,-0.0752711,-0.235484,0,6,partial,33.2,17.3,18,"bone marrow: 33.2 nTPM (vital, limit 2); thymus: 18 nTPM (manageable, limit 5); lymph node: 17.3 nTPM (protected, limit 3); skin: 8.9 nTPM (manageable, limit 5); rectum: 7.8 nTPM (protected, limit 3); esophagus: 7.3 nTPM (protected, limit 3); colon: 7.1 nTPM (protected, limit 3); duodenum: 6.4 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 3); heart muscle: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); smooth muscle: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 3); liver: 3.5 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CENPH,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000153060,True,compatible,,True,True,True,,0.346805,0.271963,0.225,0,80,unavailable,0.8,0.9,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEKT5,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000153093,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lung: 44.0252% (minimum 75%, Missing); urinary bladder: 60.8696% (minimum 70%, Missing)",0.271053,-0.0913043,-0.309748,0,80,unavailable,8.9,4.5,0.6,"lung: 8.9 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 3); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ACOXL,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000153132,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328705,0.286583,0.0577221,0,1,partial,57.4,2.5,2.6,"heart muscle: 57.4 nTPM (vital, limit 6); retina: 16.7 nTPM (vital, limit 1); pituitary gland: 10.9 nTPM (vital, limit 1); cerebellum: 7.9 nTPM (vital, limit 6); choroid plexus: 7.9 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 6); hypothalamus: 4.8 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CLGN,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000153157,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 72.0930% (minimum 75%, Missing); heart muscle: 72.0930% (minimum 75%, Missing); kidney: 73.8095% (minimum 75%, Missing); lung: 64.5833% (minimum 75%, Missing); pancreas: 65.9574% (minimum 75%, Missing); parathyroid gland: 4.4604% (minimum 70%, Missing)",0.0880952,-0.655396,-0.104167,0,80,unavailable,1.7,66.4,1.1,"parathyroid gland: 66.4 nTPM (protected, limit 3); lung: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SYCP2L,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000153165,True,compatible,,True,True,True,,0.12907,0.257143,0.131579,0,80,unavailable,0.9,0.3,1.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RGPD3,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,True,True,True,True,gained,selectivity_revised
ENSG00000153207,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 65.3527% (minimum 75%, Missing); liver: 74.8219% (minimum 75%, Missing); skeletal muscle: 74.8219% (minimum 75%, Missing); tongue: 67.5966% (minimum 70%, Missing)",0.053125,-0.0240343,-0.096473,0,2,partial,16.7,15.1,13.3,"bone marrow: 16.7 nTPM (vital, limit 1); tongue: 15.1 nTPM (protected, limit 3); thyroid gland: 13.3 nTPM (manageable, limit 5); parathyroid gland: 12.7 nTPM (protected, limit 3); adipose tissue: 12.2 nTPM (manageable, limit 5); thymus: 11.9 nTPM (manageable, limit 5); liver: 10.6 nTPM (vital, limit 1); skeletal muscle: 10.6 nTPM (vital, limit 1); urinary bladder: 9.9 nTPM (protected, limit 3); pancreas: 9.6 nTPM (vital, limit 1); kidney: 9.4 nTPM (vital, limit 1); spleen: 9 nTPM (manageable, limit 5); lymph node: 8.9 nTPM (protected, limit 3); esophagus: 8.9 nTPM (protected, limit 3); colon: 8.8 nTPM (protected, limit 3); stomach: 8.3 nTPM (protected, limit 3); cerebellum: 8.2 nTPM (vital, limit 1); skin: 7.8 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); lung: 6.9 nTPM (vital, limit 1); rectum: 6.7 nTPM (protected, limit 3); salivary gland: 6.6 nTPM (protected, limit 3); cerebral cortex: 6.6 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AHCTF1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000153237,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 62.3377% (minimum 75%, Missing); kidney: 61.5385% (minimum 75%, Missing); parathyroid gland: 60.7595% (minimum 70%, Missing); retina: 65.7534% (minimum 75%, Missing)",0.15,-0.0924051,-0.134615,0,80,unavailable,3,3.1,1.2,"parathyroid gland: 3.1 nTPM (protected, limit 3); kidney: 3 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC148,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000153347,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 57.2336% (minimum 75%, Missing)",0.35,0.3,-0.177664,0,2,partial,60.6,2.4,1.6,"choroid plexus: 60.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 2); hypothalamus: 6.7 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 2); pituitary gland: 3.6 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM81B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000153495,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.336301,0.290177,0.0576923,0,80,unavailable,12,0.5,0.7,"cerebral cortex: 12 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX29,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000153498,True,compatible,,True,True,True,,0.35,0.3,0.246341,0,3,partial,0.5,0.3,0.2,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPACA7,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000153684,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.24187,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,GOLGA8F,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000153721,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 52.4823% (minimum 75%, Missing); colon: 54.0146% (minimum 70%, Missing); duodenum: 56.9231% (minimum 75%, Missing); esophagus: 36.6337% (minimum 70%, Missing); heart muscle: 54.8148% (minimum 75%, Missing); kidney: 50.3401% (minimum 75%, Missing); liver: 44.3114% (minimum 75%, Missing); lung: 67.2727% (minimum 75%, Missing); pancreas: 28.7938% (minimum 75%, Missing); rectum: 69.1589% (minimum 70%, Missing); retina: 74.7475% (minimum 75%, Missing); salivary gland: 57.3643% (minimum 65%, Approved); small intestine: 54.4118% (minimum 75%, Missing); smooth muscle: 54.0146% (minimum 70%, Approved); spinal cord: 65.4867% (minimum 75%, Missing); spleen: 62.7119% (minimum 65%, Missing); stomach: 65.4867% (minimum 70%, Missing); urinary bladder: 63.7931% (minimum 70%, Missing)",-0.0228814,-0.333663,-0.462062,0,1,partial,18.3,12.8,4.4,"pancreas: 18.3 nTPM (vital, limit 1); esophagus: 12.8 nTPM (protected, limit 3); liver: 9.3 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); choroid plexus: 6.7 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 3); smooth muscle: 6.3 nTPM (vital, limit 2); small intestine: 6.2 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 4); urinary bladder: 4.2 nTPM (protected, limit 3); stomach: 3.9 nTPM (protected, limit 3); spinal cord: 3.9 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); rectum: 3.3 nTPM (protected, limit 3); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CNKSR3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000153779,True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TGIF2LX,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000153790,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.288053,0.205983,0.143258,0,80,unavailable,7.6,6.6,4.2,"adrenal gland: 7.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 3); stomach: 4.4 nTPM (protected, limit 3); rectum: 4.4 nTPM (protected, limit 3); duodenum: 4.3 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 3); small intestine: 3.7 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); salivary gland: 3.4 nTPM (protected, limit 3); lymph node: 3.2 nTPM (protected, limit 3); spinal cord: 2.9 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPMIP4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000153898,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 31.4516% (minimum 75%, Missing); bone marrow: 59.0909% (minimum 75%, Missing); colon: 28.4672% (minimum 70%, Missing); duodenum: 70.9091% (minimum 75%, Missing); lung: 42.3913% (minimum 75%, Missing); lymph node: 23.7805% (minimum 70%, Missing); rectum: 21.0811% (minimum 70%, Missing); small intestine: 42.3913% (minimum 75%, Missing); spleen: 37.1429% (minimum 65%, Missing); stomach: 65.0000% (minimum 70%, Missing); thymus: 63.9344% (minimum 65%, Missing)",-0.278571,-0.489189,-0.435484,0,80,unavailable,8.5,14.6,6.6,"rectum: 14.6 nTPM (protected, limit 3); lymph node: 12.5 nTPM (protected, limit 3); colon: 9.8 nTPM (protected, limit 3); adrenal gland: 8.5 nTPM (vital, limit 1); spleen: 6.6 nTPM (manageable, limit 5); lung: 5.3 nTPM (vital, limit 1); small intestine: 5.3 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MCOLN2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000153982,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 61.4815% (minimum 75%, Missing); basal ganglia: 58.8652% (minimum 75%, Missing); cerebellum: 45.3552% (minimum 75%, Missing); cerebral cortex: 41.7085% (minimum 75%, Missing); choroid plexus: 74.1071% (minimum 75%, Missing); duodenum: 59.7122% (minimum 75%, Missing); hippocampal formation: 58.0420% (minimum 75%, Missing); hypothalamus: 52.2013% (minimum 75%, Missing); midbrain: 62.8788% (minimum 75%, Missing); parathyroid gland: 59.2857% (minimum 70%, Missing); retina: 59.7122% (minimum 75%, Missing); small intestine: 66.9355% (minimum 75%, Missing); spinal cord: 65.8730% (minimum 75%, Missing); stomach: 62.4060% (minimum 70%, Missing)",0.118519,-0.107143,-0.332915,0,80,unavailable,11.6,5.7,2.5,"cerebral cortex: 11.6 nTPM (vital, limit 1); cerebellum: 10 nTPM (vital, limit 1); hypothalamus: 7.6 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); parathyroid gland: 5.7 nTPM (protected, limit 3); retina: 5.6 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); stomach: 5 nTPM (protected, limit 3); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GDPD1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000154007,True,compatible,,True,True,True,,0.35,0.3,0.245893,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ASB17,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000154040,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345278,0.299661,0.208739,0,1,partial,12.7,2.3,2,"choroid plexus: 12.7 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 6); hippocampal formation: 7 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 5.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CABYR,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000154059,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 62.1974% (minimum 75%, Missing); amygdala: 73.8938% (minimum 75%, Missing); basal ganglia: 71.5203% (minimum 75%, Missing); bone marrow: 68.1633% (minimum 75%, Missing); cerebral cortex: 70.0210% (minimum 75%, Missing); colon: 65.7480% (minimum 70%, Missing); duodenum: 68.1633% (minimum 75%, Missing); esophagus: 61.3971% (minimum 70%, Missing); heart muscle: 64.2308% (minimum 75%, Missing); hypothalamus: 65.7480% (minimum 75%, Missing); kidney: 58.6995% (minimum 75%, Missing); liver: 60.7273% (minimum 70%, Approved); lung: 68.7243% (minimum 70%, Approved); midbrain: 71.5203% (minimum 75%, Missing); pancreas: 62.6642% (minimum 75%, Missing); parathyroid gland: 55.3897% (minimum 65%, Approved); rectum: 69.8745% (minimum 70%, Missing); salivary gland: 57.9861% (minimum 70%, Missing); skeletal muscle: 63.0189% (minimum 75%, Missing); small intestine: 67.6113% (minimum 75%, Missing); smooth muscle: 72.7669% (minimum 75%, Missing); spinal cord: 68.7243% (minimum 75%, Missing); stomach: 68.4426% (minimum 70%, Missing); thyroid gland: 51.4638% (minimum 65%, Missing)",-0.135362,-0.120139,-0.163005,0,3,partial,23.5,26.9,31.5,"thyroid gland: 31.5 nTPM (manageable, limit 5); parathyroid gland: 26.9 nTPM (protected, limit 4); salivary gland: 24.2 nTPM (protected, limit 3); kidney: 23.5 nTPM (vital, limit 1); liver: 21.6 nTPM (vital, limit 2); esophagus: 21 nTPM (protected, limit 3); adrenal gland: 20.3 nTPM (vital, limit 1); pancreas: 19.9 nTPM (vital, limit 1); skeletal muscle: 19.6 nTPM (vital, limit 1); adipose tissue: 18.7 nTPM (manageable, limit 10); heart muscle: 18.6 nTPM (vital, limit 1); hypothalamus: 17.4 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 3); small intestine: 16 nTPM (vital, limit 1); duodenum: 15.6 nTPM (vital, limit 1); bone marrow: 15.6 nTPM (vital, limit 1); stomach: 15.4 nTPM (protected, limit 3); spinal cord: 15.2 nTPM (vital, limit 1); lung: 15.2 nTPM (vital, limit 2); spleen: 14.8 nTPM (manageable, limit 10); rectum: 14.4 nTPM (protected, limit 3); cerebral cortex: 14.3 nTPM (vital, limit 1); midbrain: 13.3 nTPM (vital, limit 1); basal ganglia: 13.3 nTPM (vital, limit 1); tongue: 12.6 nTPM (protected, limit 3); smooth muscle: 12.5 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 3); amygdala: 11.8 nTPM (vital, limit 1); lymph node: 11.2 nTPM (protected, limit 3); skin: 11.1 nTPM (manageable, limit 5); thymus: 10.9 nTPM (manageable, limit 5); retina: 9.8 nTPM (vital, limit 1); pituitary gland: 9.7 nTPM (vital, limit 1); hippocampal formation: 9.7 nTPM (vital, limit 1); choroid plexus: 8.9 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IMPACT,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000154099,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 64.9408% (minimum 75%, Missing)",0.35,0.3,-0.100592,0,5,partial,23.7,0.4,1.5,"choroid plexus: 23.7 nTPM (vital, limit 1); hypothalamus: 8.1 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAAF1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000154114,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 63.5000% (minimum 75%, Missing); amygdala: 74.2690% (minimum 75%, Missing); basal ganglia: 72.1591% (minimum 75%, Missing); bone marrow: 69.7802% (minimum 75%, Missing); cerebellum: 72.9885% (minimum 75%, Missing); cerebral cortex: 66.1458% (minimum 75%, Missing); choroid plexus: 46.8635% (minimum 75%, Missing); colon: 64.4670% (minimum 70%, Missing); duodenum: 72.5714% (minimum 75%, Missing); esophagus: 69.7802% (minimum 70%, Missing); heart muscle: 57.9909% (minimum 75%, Missing); hippocampal formation: 71.7514% (minimum 75%, Missing); hypothalamus: 72.9885% (minimum 75%, Missing); kidney: 62.5616% (minimum 75%, Missing); liver: 47.3881% (minimum 70%, Approved); lung: 58.2569% (minimum 75%, Missing); lymph node: 64.4670% (minimum 70%, Missing); midbrain: 71.7514% (minimum 75%, Missing); pancreas: 68.2796% (minimum 75%, Missing); parathyroid gland: 46.0145% (minimum 70%, Missing); pituitary gland: 62.8713% (minimum 75%, Missing); rectum: 69.7802% (minimum 70%, Missing); retina: 61.3527% (minimum 75%, Missing); salivary gland: 65.4639% (minimum 70%, Missing); skeletal muscle: 69.0217% (minimum 75%, Missing); small intestine: 69.7802% (minimum 75%, Missing); smooth muscle: 58.7963% (minimum 75%, Missing); spinal cord: 67.5532% (minimum 75%, Missing); spleen: 62.2549% (minimum 65%, Missing); stomach: 69.0217% (minimum 70%, Missing); thymus: 64.7959% (minimum 65%, Missing); thyroid gland: 56.6964% (minimum 65%, Missing); tongue: 63.1841% (minimum 70%, Missing); urinary bladder: 68.2796% (minimum 70%, Missing)",-0.0830357,-0.239855,-0.281365,0,4,partial,14.4,14.9,9.7,"parathyroid gland: 14.9 nTPM (protected, limit 3); choroid plexus: 14.4 nTPM (vital, limit 1); liver: 14.1 nTPM (vital, limit 2); thyroid gland: 9.7 nTPM (manageable, limit 5); heart muscle: 9.2 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); smooth muscle: 8.9 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); kidney: 7.6 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); tongue: 7.4 nTPM (protected, limit 3); adrenal gland: 7.3 nTPM (vital, limit 1); colon: 7 nTPM (protected, limit 3); lymph node: 7 nTPM (protected, limit 3); thymus: 6.9 nTPM (manageable, limit 5); salivary gland: 6.7 nTPM (protected, limit 3); cerebral cortex: 6.5 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); urinary bladder: 5.9 nTPM (protected, limit 3); pancreas: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.7 nTPM (vital, limit 1); stomach: 5.7 nTPM (protected, limit 3); rectum: 5.5 nTPM (protected, limit 3); small intestine: 5.5 nTPM (vital, limit 1); esophagus: 5.5 nTPM (protected, limit 3); bone marrow: 5.5 nTPM (vital, limit 1); hippocampal formation: 5 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TBCEL,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000154143,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 50.0000% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing)",0.35,-0.2,-0.25,0,80,unavailable,0.2,0.2,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PANX3,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000154227,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"esophagus: 35.4217% (minimum 70%, Missing); skin: 32.1663% (minimum 65%, Missing)",-0.328337,-0.345783,0.23,0,2,partial,0.6,53.6,62,"skin: 62 nTPM (manageable, limit 5); esophagus: 53.6 nTPM (protected, limit 3); salivary gland: 8.2 nTPM (protected, limit 4)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CERS3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000154438,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ASZ1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000154479,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 62.8941% (minimum 75%, Missing)",0.347436,0.297436,-0.121059,0,6,partial,45.9,1.5,3.3,"choroid plexus: 45.9 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 2); bone marrow: 3.6 nTPM (vital, limit 2); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 2); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP210,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000154548,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 75.0000% (minimum 75%, Missing); hypothalamus: 74.0000% (minimum 75%, Missing)",0.302439,0.180952,-0.01,0,3,partial,4.2,1.5,1.2,"cerebral cortex: 4.2 nTPM (vital, limit 2); hypothalamus: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 2); basal ganglia: 3.3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SRSF12,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000154611,True,compatible,,True,True,True,,0.320414,0.226554,0.243939,0,80,unavailable,0.1,1.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PSMA8,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000154645,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.187215,0.198507,0.0421053,0,2,partial,7.9,3.4,13.7,"hypothalamus: 7.9 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); pituitary gland: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CHODL,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000154655,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 74.5455% (minimum 75%, Missing); kidney: 64.0625% (minimum 75%, Missing); liver: 59.1346% (minimum 70%, Approved); pancreas: 66.1290% (minimum 75%, Missing); parathyroid gland: 60.0000% (minimum 65%, Approved); skin: 63.7306% (minimum 65%, Missing)",-0.0126943,-0.05,-0.109375,0,2,partial,8.5,8.2,7,"liver: 8.5 nTPM (vital, limit 2); parathyroid gland: 8.2 nTPM (protected, limit 4); skin: 7 nTPM (manageable, limit 5); kidney: 6.9 nTPM (vital, limit 1); pancreas: 6.3 nTPM (vital, limit 1); thyroid gland: 5.6 nTPM (manageable, limit 5); heart muscle: 4.8 nTPM (vital, limit 2); adrenal gland: 4.2 nTPM (vital, limit 1); lung: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); esophagus: 3.4 nTPM (protected, limit 3); amygdala: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); stomach: 3.1 nTPM (protected, limit 3); pituitary gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 2); basal ganglia: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,L3MBTL4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000154710,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.0422% (minimum 65%, Missing); adrenal gland: 64.0625% (minimum 75%, Missing); bone marrow: 24.4533% (minimum 75%, Missing); cerebellum: 65.4255% (minimum 75%, Missing); cerebral cortex: 66.3073% (minimum 75%, Missing); choroid plexus: 64.5669% (minimum 75%, Missing); esophagus: 56.1644% (minimum 70%, Missing); heart muscle: 71.9298% (minimum 75%, Missing); kidney: 68.7151% (minimum 75%, Missing); liver: 62.7551% (minimum 75%, Missing); lung: 70.4871% (minimum 75%, Missing); lymph node: 68.3333% (minimum 70%, Missing); pancreas: 72.3529% (minimum 75%, Missing); parathyroid gland: 63.0769% (minimum 70%, Missing); rectum: 67.9558% (minimum 70%, Missing); retina: 33.6525% (minimum 75%, Missing); skeletal muscle: 65.7754% (minimum 75%, Missing); skin: 51.3570% (minimum 65%, Missing); small intestine: 73.2143% (minimum 75%, Missing); smooth muscle: 67.2131% (minimum 75%, Missing); thyroid gland: 61.1940% (minimum 65%, Missing); tongue: 65.6000% (minimum 70%, Missing); urinary bladder: 57.0766% (minimum 70%, Missing)",-0.13643,-0.138356,-0.505467,0,80,unavailable,76,19.2,23.3,"bone marrow: 76 nTPM (vital, limit 1); retina: 48.5 nTPM (vital, limit 1); skin: 23.3 nTPM (manageable, limit 5); esophagus: 19.2 nTPM (protected, limit 3); urinary bladder: 18.5 nTPM (protected, limit 3); adipose tissue: 15.7 nTPM (manageable, limit 5); thyroid gland: 15.6 nTPM (manageable, limit 5); liver: 14.6 nTPM (vital, limit 1); parathyroid gland: 14.4 nTPM (protected, limit 3); adrenal gland: 13.8 nTPM (vital, limit 1); choroid plexus: 13.5 nTPM (vital, limit 1); thymus: 13 nTPM (manageable, limit 5); cerebellum: 13 nTPM (vital, limit 1); tongue: 12.9 nTPM (protected, limit 3); skeletal muscle: 12.8 nTPM (vital, limit 1); cerebral cortex: 12.5 nTPM (vital, limit 1); smooth muscle: 12 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 3); lymph node: 11.4 nTPM (protected, limit 3); kidney: 11.2 nTPM (vital, limit 1); colon: 10.5 nTPM (protected, limit 3); lung: 10.3 nTPM (vital, limit 1); stomach: 10.3 nTPM (protected, limit 3); heart muscle: 9.6 nTPM (vital, limit 1); spleen: 9.5 nTPM (manageable, limit 5); pancreas: 9.4 nTPM (vital, limit 1); small intestine: 9 nTPM (vital, limit 1); salivary gland: 8.5 nTPM (protected, limit 3); duodenum: 7.8 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RABGEF1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000154727,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.1022% (minimum 65%, Missing); adrenal gland: 63.8814% (minimum 75%, Missing); basal ganglia: 73.1481% (minimum 75%, Missing); bone marrow: 60.0000% (minimum 65%, Supported); cerebral cortex: 73.6025% (minimum 75%, Missing); colon: 66.2011% (minimum 70%, Missing); duodenum: 65.2893% (minimum 75%, Missing); esophagus: 68.4971% (minimum 70%, Missing); kidney: 64.0541% (minimum 75%, Missing); liver: 55.8962% (minimum 65%, Supported); lung: 64.7541% (minimum 75%, Missing); lymph node: 54.3578% (minimum 70%, Missing); pancreas: 70.5357% (minimum 75%, Missing); parathyroid gland: 61.5584% (minimum 70%, Missing); rectum: 64.0541% (minimum 70%, Missing); retina: 68.1034% (minimum 75%, Missing); skeletal muscle: 69.9115% (minimum 75%, Missing); small intestine: 64.5777% (minimum 75%, Missing); smooth muscle: 61.5584% (minimum 75%, Missing); spinal cord: 73.1481% (minimum 75%, Missing); spleen: 56.5632% (minimum 65%, Missing); stomach: 67.3295% (minimum 70%, Missing); thymus: 52.4336% (minimum 65%, Missing); thyroid gland: 53.4989% (minimum 65%, Missing); tongue: 59.8485% (minimum 70%, Missing); urinary bladder: 65.4696% (minimum 70%, Missing)",-0.125664,-0.156422,-0.134416,0,2,partial,18.7,19.9,21.5,"thymus: 21.5 nTPM (manageable, limit 5); thyroid gland: 20.6 nTPM (manageable, limit 5); lymph node: 19.9 nTPM (protected, limit 3); liver: 18.7 nTPM (vital, limit 3); spleen: 18.2 nTPM (manageable, limit 5); adipose tissue: 16.4 nTPM (manageable, limit 5); tongue: 15.9 nTPM (protected, limit 3); bone marrow: 15.8 nTPM (vital, limit 3); smooth muscle: 14.8 nTPM (vital, limit 1); parathyroid gland: 14.8 nTPM (protected, limit 3); adrenal gland: 13.4 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 3); kidney: 13.3 nTPM (vital, limit 1); small intestine: 13 nTPM (vital, limit 1); lung: 12.9 nTPM (vital, limit 1); duodenum: 12.6 nTPM (vital, limit 1); urinary bladder: 12.5 nTPM (protected, limit 3); heart muscle: 12.5 nTPM (vital, limit 3); colon: 12.1 nTPM (protected, limit 3); stomach: 11.5 nTPM (protected, limit 3); retina: 11.1 nTPM (vital, limit 1); esophagus: 10.9 nTPM (protected, limit 3); skeletal muscle: 10.2 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 3); skin: 10 nTPM (manageable, limit 5); pancreas: 9.9 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); spinal cord: 8.7 nTPM (vital, limit 1); cerebral cortex: 8.5 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 3); midbrain: 6.8 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Medium (Supported); bronchus / respiratory epithelial cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Low (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Low (Supported); spleen / cells in red pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GABPA,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000154764,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 41.2698% (minimum 75%, Missing); basal ganglia: 44.8276% (minimum 75%, Missing); cerebral cortex: 39.3939% (minimum 70%, Approved); hippocampal formation: 61.9048% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); lung: 56.5217% (minimum 70%, Approved); midbrain: 63.4146% (minimum 75%, Missing); spinal cord: 74.2857% (minimum 75%, Missing)",0.0842105,0.216667,-0.337302,0,1,partial,4,0.4,1.2,"cerebral cortex: 4 nTPM (vital, limit 2); amygdala: 3.7 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,WNT7A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000154839,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 25.7862% (minimum 75%, Missing); duodenum: 70.6897% (minimum 75%, Missing); esophagus: 62.1212% (minimum 70%, Missing); lymph node: 46.5909% (minimum 70%, Missing); rectum: 67.2131% (minimum 70%, Missing); thymus: 53.9474% (minimum 65%, Missing)",-0.110526,-0.234091,-0.492138,0,3,partial,11.8,4.7,3.5,"bone marrow: 11.8 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SKA1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000154920,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 59.0476% (minimum 75%, Missing)",0.00957447,0.0380952,-0.159524,0,2,partial,4.3,2.2,3.2,"bone marrow: 4.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EME1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000154928,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 58.7571% (minimum 75%, Missing); basal ganglia: 41.2698% (minimum 75%, Missing); cerebellum: 33.9869% (minimum 75%, Missing); cerebral cortex: 43.5146% (minimum 60%, Enhanced); hippocampal formation: 67.0968% (minimum 75%, Missing); hypothalamus: 72.7273% (minimum 75%, Missing); retina: 72.2222% (minimum 75%, Missing); thyroid gland: 60.4651% (minimum 65%, Missing); tongue: 51.2315% (minimum 70%, Missing)",-0.0453488,-0.187685,-0.410131,0,9,partial,20.2,9.9,6.8,"cerebellum: 20.2 nTPM (vital, limit 1); basal ganglia: 14.8 nTPM (vital, limit 1); cerebral cortex: 13.5 nTPM (vital, limit 6); tongue: 9.9 nTPM (protected, limit 3); amygdala: 7.3 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); hippocampal formation: 5.1 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); midbrain: 1.5 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Low (Enhanced); cerebellum / processes in granular layer: Low (Enhanced); cerebellum / processes in molecular layer: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EPHB1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000154997,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.298276,0.277778,0.166667,0,3,partial,2.3,1.1,1.4,"retina: 2 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SEPTIN14,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000155026,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.294819,0.0705128,0,4,partial,4.2,0.9,1,"choroid plexus: 4.2 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RSPH10B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000155085,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 73.8532% (minimum 75%, Missing); choroid plexus: 50.9494% (minimum 75%, Missing); hippocampal formation: 73.8532% (minimum 75%, Missing); hypothalamus: 70.6140% (minimum 75%, Missing); midbrain: 72.1973% (minimum 75%, Missing); parathyroid gland: 64.6586% (minimum 70%, Missing); pituitary gland: 68.2203% (minimum 75%, Missing); retina: 54.2088% (minimum 75%, Missing); spinal cord: 68.5106% (minimum 75%, Missing)",0.0380342,-0.0534137,-0.240506,0,2,partial,15.5,8.8,7.3,"choroid plexus: 15.5 nTPM (vital, limit 1); retina: 13.6 nTPM (vital, limit 1); parathyroid gland: 8.8 nTPM (protected, limit 3); pituitary gland: 7.5 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); hypothalamus: 6.7 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); midbrain: 6.2 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); basal ganglia: 5.2 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 3); cerebral cortex: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); colon: 4.4 nTPM (protected, limit 3); rectum: 4.2 nTPM (protected, limit 3); esophagus: 4.1 nTPM (protected, limit 3); lymph node: 4 nTPM (protected, limit 3); lung: 4 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 3); urinary bladder: 3.3 nTPM (protected, limit 3); pancreas: 3.3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / endothelial cells: High (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: High (Enhanced); lung / alveolar cells: High (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: High (Enhanced); skin 1 / Langerhans: High (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / chondrocytes: High (Enhanced); soft tissue 2 / fibroblasts: High (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AK9,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000155087,True,compatible,,True,True,True,,0.35,0.3,0.24819,0,1,partial,0.7,0.1,0.1,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ODF1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000155249,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR4K1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000155313,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 66.2043% (minimum 75%, Missing); heart muscle: 65.8720% (minimum 75%, Missing); kidney: 71.9178% (minimum 75%, Missing); liver: 73.0181% (minimum 75%, Missing); lung: 69.5364% (minimum 75%, Missing); skeletal muscle: 31.1019% (minimum 75%, Missing); smooth muscle: 59.8632% (minimum 75%, Missing); tongue: 41.9329% (minimum 70%, Missing)",0.0282946,-0.280671,-0.438981,0,0,routine_complete,116.3,72.7,24.9,"skeletal muscle: 116.3 nTPM (vital, limit 1); tongue: 72.7 nTPM (protected, limit 3); smooth muscle: 35.2 nTPM (vital, limit 1); heart muscle: 27.2 nTPM (vital, limit 1); bone marrow: 26.8 nTPM (vital, limit 1); thymus: 24.9 nTPM (manageable, limit 5); adipose tissue: 24.6 nTPM (manageable, limit 5); lung: 23 nTPM (vital, limit 1); esophagus: 21 nTPM (protected, limit 3); kidney: 20.5 nTPM (vital, limit 1); lymph node: 19.6 nTPM (protected, limit 3); liver: 19.4 nTPM (vital, limit 1); spleen: 18.6 nTPM (manageable, limit 5); salivary gland: 16.8 nTPM (protected, limit 3); rectum: 15.6 nTPM (protected, limit 3); pancreas: 15.4 nTPM (vital, limit 1); basal ganglia: 15.3 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); urinary bladder: 14.9 nTPM (protected, limit 3); colon: 14.8 nTPM (protected, limit 3); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 13.7 nTPM (protected, limit 3); small intestine: 13 nTPM (vital, limit 1); hippocampal formation: 13 nTPM (vital, limit 1); amygdala: 12.8 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 3); skin: 12.6 nTPM (manageable, limit 5); adrenal gland: 12.5 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); spinal cord: 9.5 nTPM (vital, limit 1); retina: 9.3 nTPM (vital, limit 1); choroid plexus: 9.2 nTPM (vital, limit 1); midbrain: 8.6 nTPM (vital, limit 1); hypothalamus: 7.5 nTPM (vital, limit 1); pituitary gland: 7.4 nTPM (vital, limit 1); cerebellum: 7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,USP25,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000155330,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 60.5442% (minimum 75%, Uncertain); heart muscle: 74.7899% (minimum 75%, Missing); kidney: 70.9163% (minimum 75%, Missing); liver: 58.3607% (minimum 75%, Uncertain); skeletal muscle: 57.4194% (minimum 75%, Missing)",0.174074,0.012,-0.175806,0,1,partial,13.2,7.2,3.8,"skeletal muscle: 13.2 nTPM (vital, limit 1); liver: 12.7 nTPM (vital, limit 1); bone marrow: 11.6 nTPM (vital, limit 1); kidney: 7.3 nTPM (vital, limit 1); tongue: 7.2 nTPM (protected, limit 3); heart muscle: 6 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 3); basal ganglia: 5.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 3); small intestine: 4.6 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 3); urinary bladder: 4 nTPM (protected, limit 3); hippocampal formation: 4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); lung: 3.9 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 3); pituitary gland: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); salivary gland: 3.2 nTPM (protected, limit 3); spinal cord: 3.2 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",caudate / glial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C16orf87,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000155367,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"skeletal muscle: 45.8919% (minimum 75%, Missing); tongue: 69.5847% (minimum 70%, Missing)",0.111671,-0.00415264,-0.291081,0,6,partial,73.1,27.1,19.4,"skeletal muscle: 73.1 nTPM (vital, limit 1); tongue: 27.1 nTPM (protected, limit 3); skin: 19.4 nTPM (manageable, limit 5); cerebellum: 15.5 nTPM (vital, limit 1); heart muscle: 8.4 nTPM (vital, limit 1); cerebral cortex: 8 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); retina: 7.4 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 3); hippocampal formation: 5.1 nTPM (vital, limit 1); midbrain: 4.7 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); esophagus: 4.4 nTPM (protected, limit 3); lymph node: 3.5 nTPM (protected, limit 3); choroid plexus: 3.5 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PPM1J,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000155495,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEC1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000155530,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 60.9756% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing)",0.259091,0.209091,-0.140244,0,80,unavailable,3.2,0.5,0.5,"choroid plexus: 3.2 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRGUK,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000155592,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 71.4286% (minimum 75%, Missing); basal ganglia: 72.7273% (minimum 75%, Missing); bone marrow: 68.9655% (minimum 75%, Missing); cerebellum: 68.9655% (minimum 75%, Missing); cerebral cortex: 64.5161% (minimum 75%, Missing); heart muscle: 68.9655% (minimum 75%, Missing); hippocampal formation: 71.4286% (minimum 75%, Missing); hypothalamus: 67.7966% (minimum 75%, Missing); kidney: 72.7273% (minimum 75%, Missing); liver: 71.4286% (minimum 75%, Missing); midbrain: 72.7273% (minimum 75%, Missing); parathyroid gland: 58.8235% (minimum 70%, Missing); pituitary gland: 71.4286% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); skeletal muscle: 56.3380% (minimum 75%, Missing); smooth muscle: 68.9655% (minimum 75%, Missing); spinal cord: 71.4286% (minimum 75%, Missing); thymus: 63.4921% (minimum 65%, Missing); tongue: 47.6190% (minimum 70%, Missing)",-0.0150794,-0.22381,-0.25,0,80,unavailable,4,4.4,2.3,"tongue: 4.4 nTPM (protected, limit 3); retina: 4 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZKSCAN2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000155621,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.9888% (minimum 60%, Approved); adrenal gland: 62.1302% (minimum 75%, Missing); amygdala: 60.0000% (minimum 75%, Missing); basal ganglia: 59.6591% (minimum 75%, Missing); bone marrow: 64.4172% (minimum 70%, Approved); cerebral cortex: 64.0244% (minimum 75%, Missing); choroid plexus: 74.4681% (minimum 75%, Missing); colon: 58.6592% (minimum 70%, Missing); duodenum: 48.3871% (minimum 75%, Missing); esophagus: 52.2388% (minimum 70%, Missing); heart muscle: 64.0244% (minimum 75%, Missing); hippocampal formation: 58.9888% (minimum 75%, Missing); hypothalamus: 60.6936% (minimum 75%, Missing); kidney: 61.0465% (minimum 75%, Missing); liver: 58.3333% (minimum 75%, Missing); lung: 68.1818% (minimum 75%, Missing); lymph node: 55.8511% (minimum 65%, Approved); midbrain: 56.7568% (minimum 75%, Missing); pancreas: 58.0110% (minimum 75%, Missing); parathyroid gland: 69.0789% (minimum 70%, Missing); pituitary gland: 64.4172% (minimum 75%, Missing); rectum: 59.3220% (minimum 70%, Missing); retina: 63.6364% (minimum 75%, Missing); salivary gland: 55.2632% (minimum 70%, Missing); skeletal muscle: 55.8511% (minimum 75%, Missing); skin: 49.5283% (minimum 65%, Missing); small intestine: 57.0652% (minimum 75%, Missing); smooth muscle: 63.6364% (minimum 70%, Approved); spinal cord: 50.7246% (minimum 75%, Missing); stomach: 61.4035% (minimum 70%, Missing); thymus: 56.1497% (minimum 65%, Missing); thyroid gland: 56.1497% (minimum 65%, Missing); tongue: 57.0652% (minimum 70%, Missing); urinary bladder: 53.0303% (minimum 70%, Missing)",-0.154717,-0.177612,-0.266129,0,7,partial,11.2,9.6,10.7,"duodenum: 11.2 nTPM (vital, limit 1); skin: 10.7 nTPM (manageable, limit 5); spinal cord: 10.2 nTPM (vital, limit 1); esophagus: 9.6 nTPM (protected, limit 3); urinary bladder: 9.3 nTPM (protected, limit 3); salivary gland: 8.5 nTPM (protected, limit 3); lymph node: 8.3 nTPM (protected, limit 4); skeletal muscle: 8.3 nTPM (vital, limit 1); thyroid gland: 8.2 nTPM (manageable, limit 5); thymus: 8.2 nTPM (manageable, limit 5); midbrain: 8 nTPM (vital, limit 1); tongue: 7.9 nTPM (protected, limit 3); small intestine: 7.9 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); liver: 7.5 nTPM (vital, limit 1); colon: 7.4 nTPM (protected, limit 3); hippocampal formation: 7.3 nTPM (vital, limit 1); rectum: 7.2 nTPM (protected, limit 3); basal ganglia: 7.1 nTPM (vital, limit 1); amygdala: 7 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 3); adrenal gland: 6.4 nTPM (vital, limit 1); smooth muscle: 6 nTPM (vital, limit 2); retina: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); heart muscle: 5.9 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 2); lung: 4.9 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 3); choroid plexus: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C9orf85,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000155622,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.348962,0.299481,0.222222,0,3,unreliable,5.5,0.1,0.2,"lung: 5.5 nTPM (vital, limit 1)",small intestine / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); thyroid gland / glandular cells: Low (Supported),50,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,XAGE2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000155714,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340826,0.281818,0.09375,0,80,unavailable,2,0.2,0.1,"cerebellum: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PDZD9,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000155719,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.0110169,0.3,0.156977,0,1,partial,0.4,0.2,2,,spleen / cells in red pulp: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OTOA,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000155749,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 65.6126% (minimum 75%, Missing)",0.262088,0.222222,-0.0938735,0,80,unavailable,8.7,1.4,1.6,"choroid plexus: 8.7 nTPM (vital, limit 1); bone marrow: 5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FLACC1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000155754,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.334733,0.294859,0.219925,0,80,unavailable,1.2,0.2,0.6,"choroid plexus: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C2CD6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000155833,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CYLC2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000155875,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.347333,0.3,0.244681,0,2,partial,0.2,0.1,0.2,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SAXO1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000155890,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRIM42,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000156009,True,compatible,,True,True,True,,0.35,0.3,0.242248,0,3,partial,0.2,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEA8,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,"Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased",True,True,True,True,True,unchanged,
ENSG00000156042,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 24.8718% (minimum 75%, Missing); pituitary gland: 59.6923% (minimum 75%, Missing); retina: 65.9864% (minimum 75%, Missing)",0.260784,0.27,-0.501282,0,6,partial,58.6,4.1,6.1,"choroid plexus: 58.6 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); retina: 10 nTPM (vital, limit 1); kidney: 7.6 nTPM (vital, limit 6); hypothalamus: 4.8 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); lung / macrophages: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP70,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000156172,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.0909% (minimum 75%, Missing); amygdala: 63.3333% (minimum 75%, Missing); basal ganglia: 58.4615% (minimum 75%, Missing); cerebellum: 67.8571% (minimum 70%, Approved); cerebral cortex: 61.2903% (minimum 75%, Missing); choroid plexus: 59.3750% (minimum 75%, Missing); heart muscle: 59.3750% (minimum 75%, Missing); hippocampal formation: 64.4068% (minimum 75%, Missing); hypothalamus: 63.3333% (minimum 75%, Missing); kidney: 62.2951% (minimum 75%, Missing); liver: 69.0909% (minimum 75%, Missing); lung: 71.6981% (minimum 75%, Missing); lymph node: 64.4068% (minimum 70%, Missing); midbrain: 64.4068% (minimum 75%, Missing); parathyroid gland: 53.5211% (minimum 70%, Missing); pituitary gland: 63.3333% (minimum 75%, Missing); retina: 43.6782% (minimum 75%, Missing); smooth muscle: 63.3333% (minimum 70%, Approved); spinal cord: 67.8571% (minimum 75%, Missing); thymus: 62.2951% (minimum 65%, Missing); thyroid gland: 61.2903% (minimum 65%, Missing); tongue: 67.8571% (minimum 70%, Missing)",-0.0370968,-0.164789,-0.313218,0,0,routine_complete,4.9,3.3,2.4,"retina: 4.9 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 3); basal ganglia: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP418,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000156194,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 45.4545% (minimum 75%, Missing); choroid plexus: 38.4615% (minimum 75%, Missing); retina: 0.2156% (minimum 75%, Missing)",0.183333,0.3,-0.747844,0,80,unavailable,231.4,0,0.1,"retina: 231.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PPEF2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000156269,True,compatible,,True,True,True,,0.35,0.3,0.1875,0,2,partial,0.4,0,0.1,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NAA11,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,True,True,True,True,gained,selectivity_revised
ENSG00000156273,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 35.6674% (minimum 75%, Missing); esophagus: 68.7764% (minimum 70%, Missing); liver: 62.2930% (minimum 70%, Approved); skeletal muscle: 65.8143% (minimum 70%, Approved); small intestine: 74.3161% (minimum 75%, Missing); urinary bladder: 63.0968% (minimum 70%, Missing)",0.0339161,-0.0690323,-0.393326,0,8,partial,88.2,28.6,22.6,"bone marrow: 88.2 nTPM (vital, limit 1); liver: 29.6 nTPM (vital, limit 2); urinary bladder: 28.6 nTPM (protected, limit 3); skeletal muscle: 25.4 nTPM (vital, limit 2); skin: 22.6 nTPM (manageable, limit 5); esophagus: 22.2 nTPM (protected, limit 3); lung: 20.7 nTPM (vital, limit 2); spleen: 20.1 nTPM (manageable, limit 10); small intestine: 16.9 nTPM (vital, limit 1); salivary gland: 16.9 nTPM (protected, limit 4); pancreas: 16.7 nTPM (vital, limit 2); lymph node: 16.4 nTPM (protected, limit 4); duodenum: 16.3 nTPM (vital, limit 1); smooth muscle: 15.4 nTPM (vital, limit 1); adipose tissue: 15.3 nTPM (manageable, limit 10); kidney: 15.3 nTPM (vital, limit 2); thymus: 13.8 nTPM (manageable, limit 5); stomach: 13.1 nTPM (protected, limit 3); colon: 12.9 nTPM (protected, limit 3); heart muscle: 12.7 nTPM (vital, limit 1); rectum: 12.7 nTPM (protected, limit 4); tongue: 12.3 nTPM (protected, limit 3); thyroid gland: 12.2 nTPM (manageable, limit 10); adrenal gland: 11.7 nTPM (vital, limit 2); retina: 11.5 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 2); parathyroid gland: 8.1 nTPM (protected, limit 4); spinal cord: 5.6 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); choroid plexus: 4.5 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); oral mucosa / squamous epithelial cells: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BACH1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000156313,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 46.5517% (minimum 60%, Approved); adrenal gland: 74.3119% (minimum 75%, Missing); amygdala: 68.9362% (minimum 75%, Missing); basal ganglia: 61.5970% (minimum 75%, Missing); bone marrow: 57.2438% (minimum 70%, Approved); cerebellum: 65.3226% (minimum 75%, Missing); cerebral cortex: 68.6441% (minimum 75%, Missing); choroid plexus: 51.2658% (minimum 75%, Missing); colon: 64.8000% (minimum 70%, Missing); heart muscle: 63.0350% (minimum 75%, Missing); hippocampal formation: 64.0316% (minimum 75%, Missing); hypothalamus: 58.0645% (minimum 75%, Missing); kidney: 72.9730% (minimum 75%, Missing); lung: 52.9412% (minimum 75%, Missing); midbrain: 62.5483% (minimum 75%, Missing); pancreas: 69.2308% (minimum 75%, Missing); pituitary gland: 33.6100% (minimum 75%, Missing); retina: 57.8571% (minimum 75%, Missing); skeletal muscle: 58.2734% (minimum 75%, Missing); small intestine: 64.0316% (minimum 75%, Missing); spinal cord: 59.7786% (minimum 75%, Missing); thyroid gland: 63.2812% (minimum 65%, Missing); urinary bladder: 65.8537% (minimum 70%, Missing)",-0.134483,-0.052,-0.4139,0,4,partial,32,8.8,18.6,"pituitary gland: 32 nTPM (vital, limit 1); adipose tissue: 18.6 nTPM (manageable, limit 10); choroid plexus: 15.4 nTPM (vital, limit 1); lung: 14.4 nTPM (vital, limit 1); bone marrow: 12.1 nTPM (vital, limit 2); retina: 11.8 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); skeletal muscle: 11.6 nTPM (vital, limit 1); spinal cord: 10.9 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (manageable, limit 5); small intestine: 9.1 nTPM (vital, limit 1); hippocampal formation: 9.1 nTPM (vital, limit 1); colon: 8.8 nTPM (protected, limit 3); cerebellum: 8.6 nTPM (vital, limit 1); urinary bladder: 8.4 nTPM (protected, limit 3); cerebral cortex: 7.4 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pancreas: 7.2 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 3); kidney: 6 nTPM (vital, limit 1); skin: 5.8 nTPM (manageable, limit 5); adrenal gland: 5.6 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 3); salivary gland: 5.1 nTPM (protected, limit 3); smooth muscle: 4.3 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 3); liver: 3.6 nTPM (vital, limit 1); tongue: 3.6 nTPM (protected, limit 3); rectum: 3.5 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); retina / ganglion cells : High (Approved); retina / inner nuclear layer: Medium (Approved); retina / limiting membrane: Medium (Approved); retina / nerve fiber layer: High (Approved); retina / outer plexiform layer: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RPGR,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000156384,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 64.4928% (minimum 75%, Missing); cerebral cortex: 72.9508% (minimum 75%, Missing); choroid plexus: 69.5312% (minimum 75%, Missing); heart muscle: 70.9163% (minimum 75%, Missing); lung: 74.4770% (minimum 75%, Missing); lymph node: 66.9173% (minimum 70%, Missing); midbrain: 72.6531% (minimum 75%, Missing); spinal cord: 63.5714% (minimum 75%, Missing); thymus: 61.1684% (minimum 65%, Missing)",-0.0383162,-0.0308271,-0.114286,0,80,unavailable,10.2,8.8,11.3,"thymus: 11.3 nTPM (manageable, limit 5); spinal cord: 10.2 nTPM (vital, limit 1); bone marrow: 9.8 nTPM (vital, limit 1); lymph node: 8.8 nTPM (protected, limit 3); choroid plexus: 7.8 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); midbrain: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); rectum: 6.2 nTPM (protected, limit 3); lung: 6.1 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); small intestine: 5.9 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); smooth muscle: 5.4 nTPM (vital, limit 1); stomach: 5.3 nTPM (protected, limit 3); urinary bladder: 5.2 nTPM (protected, limit 3); basal ganglia: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 3); amygdala: 5 nTPM (vital, limit 1); tongue: 5 nTPM (protected, limit 3); kidney: 4.7 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); hypothalamus: 4.5 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); parathyroid gland: 3.4 nTPM (protected, limit 3); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SFR1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000156466,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.239831,0.229204,0.0454545,0,80,unavailable,2.7,0.8,1.3,"heart muscle: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GDF6,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000156500,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 63.5802% (minimum 75%, Missing); choroid plexus: 59.1954% (minimum 75%, Missing); retina: 65.1899% (minimum 75%, Missing)",0.0652778,0.0152778,-0.158046,0,4,partial,7.1,4.1,4.1,"choroid plexus: 7.1 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 3); salivary gland: 4 nTPM (protected, limit 3); smooth muscle: 2.9 nTPM (vital, limit 2); cerebral cortex: 2.2 nTPM (vital, limit 2); lung: 2.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PABIR3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000156509,True,compatible,,True,True,True,,0.271053,0.245946,0.25,0,80,unavailable,0,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FBXO43,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000156876,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 52.4194% (minimum 75%, Missing); cerebellum: 68.4211% (minimum 75%, Uncertain); duodenum: 70.6522% (minimum 75%, Missing); lymph node: 61.3208% (minimum 70%, Uncertain); parathyroid gland: 63.1068% (minimum 70%, Uncertain); rectum: 69.1489% (minimum 70%, Missing); retina: 54.1667% (minimum 75%, Missing); small intestine: 74.7126% (minimum 75%, Uncertain); thymus: 60.7477% (minimum 65%, Missing)",-0.0425234,-0.0867925,-0.225806,0,4,partial,5.9,4.1,4.2,"bone marrow: 5.9 nTPM (vital, limit 1); retina: 5.5 nTPM (vital, limit 1); lymph node: 4.1 nTPM (protected, limit 3); parathyroid gland: 3.8 nTPM (protected, limit 3); cerebellum: 3 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SASS6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000156970,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 55.1020% (minimum 75%, Missing); choroid plexus: 63.1579% (minimum 75%, Missing); lymph node: 63.7168% (minimum 70%, Missing); thymus: 38.2979% (minimum 65%, Missing)",-0.267021,-0.0628319,-0.19898,0,80,unavailable,17.6,12.3,34.8,"thymus: 34.8 nTPM (manageable, limit 5); bone marrow: 17.6 nTPM (vital, limit 1); choroid plexus: 12.6 nTPM (vital, limit 1); lymph node: 12.3 nTPM (protected, limit 3); rectum: 5.8 nTPM (protected, limit 3); esophagus: 5 nTPM (protected, limit 3); duodenum: 4.5 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 3); small intestine: 4 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BUB1B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000157014,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.4396% (minimum 65%, Missing); adrenal gland: 60.9694% (minimum 75%, Missing); amygdala: 52.7594% (minimum 75%, Missing); basal ganglia: 54.3182% (minimum 75%, Missing); bone marrow: 41.2781% (minimum 75%, Missing); cerebellum: 57.0406% (minimum 75%, Missing); cerebral cortex: 50.9595% (minimum 75%, Missing); choroid plexus: 69.4767% (minimum 75%, Missing); colon: 61.4396% (minimum 70%, Missing); duodenum: 66.0221% (minimum 75%, Missing); esophagus: 55.1963% (minimum 70%, Missing); heart muscle: 60.3535% (minimum 75%, Missing); hippocampal formation: 54.5662% (minimum 75%, Missing); hypothalamus: 61.7571% (minimum 75%, Missing); kidney: 58.0097% (minimum 75%, Missing); liver: 63.5638% (minimum 75%, Missing); lung: 58.7224% (minimum 75%, Missing); lymph node: 53.1111% (minimum 70%, Missing); midbrain: 62.2396% (minimum 75%, Missing); pancreas: 55.3241% (minimum 75%, Missing); parathyroid gland: 58.0097% (minimum 70%, Missing); pituitary gland: 58.0097% (minimum 75%, Missing); rectum: 62.7297% (minimum 70%, Missing); retina: 73.3129% (minimum 75%, Missing); salivary gland: 58.1509% (minimum 70%, Missing); skeletal muscle: 62.4021% (minimum 75%, Missing); skin: 54.4419% (minimum 65%, Missing); small intestine: 56.6351% (minimum 75%, Missing); smooth muscle: 64.7696% (minimum 75%, Missing); spinal cord: 62.0779% (minimum 75%, Missing); spleen: 50.6356% (minimum 65%, Missing); stomach: 59.6010% (minimum 70%, Missing); thymus: 42.9856% (minimum 65%, Missing); thyroid gland: 54.1950% (minimum 65%, Missing); tongue: 69.6793% (minimum 70%, Missing); urinary bladder: 59.8997% (minimum 70%, Missing)",-0.220144,-0.168889,-0.337219,0,2,partial,34,21.1,31.7,"bone marrow: 34 nTPM (vital, limit 1); thymus: 31.7 nTPM (manageable, limit 5); spleen: 23.3 nTPM (manageable, limit 5); cerebral cortex: 23 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); lymph node: 21.1 nTPM (protected, limit 3); thyroid gland: 20.2 nTPM (manageable, limit 5); basal ganglia: 20.1 nTPM (vital, limit 1); skin: 20 nTPM (manageable, limit 5); hippocampal formation: 19.9 nTPM (vital, limit 1); esophagus: 19.4 nTPM (protected, limit 3); pancreas: 19.3 nTPM (vital, limit 1); small intestine: 18.3 nTPM (vital, limit 1); cerebellum: 18 nTPM (vital, limit 1); parathyroid gland: 17.3 nTPM (protected, limit 3); kidney: 17.3 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); salivary gland: 17.2 nTPM (protected, limit 3); lung: 16.8 nTPM (vital, limit 1); stomach: 16.2 nTPM (protected, limit 3); urinary bladder: 16 nTPM (protected, limit 3); heart muscle: 15.7 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); adipose tissue: 15 nTPM (manageable, limit 5); colon: 15 nTPM (protected, limit 3); hypothalamus: 14.8 nTPM (vital, limit 1); spinal cord: 14.6 nTPM (vital, limit 1); midbrain: 14.5 nTPM (vital, limit 1); skeletal muscle: 14.4 nTPM (vital, limit 1); rectum: 14.2 nTPM (protected, limit 3); liver: 13.7 nTPM (vital, limit 1); smooth muscle: 13 nTPM (vital, limit 1); duodenum: 12.3 nTPM (vital, limit 1); choroid plexus: 10.5 nTPM (vital, limit 1); tongue: 10.4 nTPM (protected, limit 3); retina: 8.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TATDN2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000157060,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,kidney / distal tubules: Medium (Enhanced),58,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SHCBP1L,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000157093,True,compatible,,True,True,True,,0.35,0.3,0.230658,0,1,partial,1,0,0.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LYZL4,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000157168,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 71.8447% (minimum 75%, Missing); cerebellum: 68.5185% (minimum 75%, Missing); cerebral cortex: 57.3643% (minimum 75%, Missing); choroid plexus: 71.1538% (minimum 75%, Missing); hypothalamus: 38.7435% (minimum 75%, Missing); kidney: 48.0519% (minimum 75%, Uncertain); liver: 30.9623% (minimum 75%, Uncertain); lung: 68.5185% (minimum 75%, Uncertain); midbrain: 63.7931% (minimum 75%, Missing); pituitary gland: 67.2727% (minimum 75%, Missing); retina: 39.5722% (minimum 75%, Missing); skin: 61.1570% (minimum 65%, Missing); thyroid gland: 44.0476% (minimum 65%, Uncertain); urinary bladder: 45.3988% (minimum 70%, Uncertain)",-0.209524,-0.246012,-0.440377,0,2,partial,16.5,8.9,9.4,"liver: 16.5 nTPM (vital, limit 1); hypothalamus: 11.7 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); thyroid gland: 9.4 nTPM (manageable, limit 5); urinary bladder: 8.9 nTPM (protected, limit 3); kidney: 8 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NRG1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000157322,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 16.3158% (minimum 75%, Missing); kidney: 11.7871% (minimum 75%, Missing); spinal cord: 73.8095% (minimum 75%, Missing)",0.0709302,0.137838,-0.632129,0,80,unavailable,23.2,0.6,1.2,"kidney: 23.2 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CLEC18A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000157330,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 51.1853% (minimum 75%, Missing)",0.337526,0.297899,-0.238147,0,80,unavailable,45.3,0.1,0.6,"choroid plexus: 45.3 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP107,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000157343,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.30559,0.278056,0.101296,0,3,partial,10.9,1.4,2.9,"pituitary gland: 10.9 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ARMC12,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000157423,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 73.2394% (minimum 75%, Missing); choroid plexus: 61.9048% (minimum 75%, Missing); hippocampal formation: 74.2857% (minimum 75%, Missing); hypothalamus: 71.2329% (minimum 75%, Missing); pituitary gland: 55.3191% (minimum 75%, Missing); retina: 44.0678% (minimum 75%, Missing)",0.242857,0.134211,-0.309322,0,13,partial,6.6,2.4,1.8,"retina: 6.6 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",nasopharynx / ciliated cells (tip of cilia): Low (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HYDIN,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000157429,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 63.2653% (minimum 75%, Missing); pancreas: 72.0930% (minimum 75%, Missing); pituitary gland: 74.8792% (minimum 75%, Missing); retina: 59.3870% (minimum 75%, Missing); skeletal muscle: 62.5000% (minimum 70%, Approved)",0.0152361,0.086802,-0.15613,0,5,partial,10.6,4.2,7.8,"retina: 10.6 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 2); choroid plexus: 9 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); skin: 6.2 nTPM (manageable, limit 5); pancreas: 6 nTPM (vital, limit 1); pituitary gland: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 2); esophagus: 4.2 nTPM (protected, limit 3); lung: 4.2 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 3); heart muscle: 4.1 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 3); small intestine: 2.9 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); bone marrow: 2.6 nTPM (vital, limit 2); liver: 2.1 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / Langerhans: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF19,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000157445,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 28.5714% (minimum 75%, Missing); amygdala: 33.3333% (minimum 75%, Missing); basal ganglia: 8.9888% (minimum 75%, Missing); cerebellum: 42.1053% (minimum 75%, Missing); cerebral cortex: 9.0909% (minimum 75%, Missing); heart muscle: 39.0244% (minimum 75%, Missing); hippocampal formation: 17.3913% (minimum 75%, Missing); hypothalamus: 19.0476% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); midbrain: 41.0256% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 36.3636% (minimum 75%, Missing); skeletal muscle: 14.4144% (minimum 75%, Missing); smooth muscle: 72.7273% (minimum 75%, Missing); spinal cord: 61.5385% (minimum 75%, Missing); tongue: 13.4454% (minimum 70%, Missing)",0.15,-0.565546,-0.660112,0,80,unavailable,16.2,10.3,0.4,"basal ganglia: 16.2 nTPM (vital, limit 1); cerebral cortex: 16 nTPM (vital, limit 1); tongue: 10.3 nTPM (protected, limit 3); skeletal muscle: 9.5 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CACNA2D3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000157456,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 47.8014% (minimum 75%, Missing); lymph node: 67.6707% (minimum 70%, Missing); thymus: 48.6291% (minimum 65%, Missing)",-0.163709,-0.0232932,-0.271986,0,12,partial,73.6,32.2,71.2,"bone marrow: 73.6 nTPM (vital, limit 1); thymus: 71.2 nTPM (manageable, limit 5); lymph node: 32.2 nTPM (protected, limit 3); rectum: 16.3 nTPM (protected, limit 3); esophagus: 15.7 nTPM (protected, limit 3); colon: 13.8 nTPM (protected, limit 3); duodenum: 13.7 nTPM (vital, limit 1); small intestine: 11.7 nTPM (vital, limit 1); skin: 9.2 nTPM (manageable, limit 5); spleen: 6.9 nTPM (manageable, limit 5); smooth muscle: 6.2 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); urinary bladder: 3.5 nTPM (protected, limit 3); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endocrine cells: High (Enhanced); colon / goblet cells: Low (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / eccrine glands: Low (Enhanced); small intestine / endocrine cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),91,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / germinal center cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / eccrine glands; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCNB2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000157578,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.347209,0.27989,0.16079,0,9,partial,10.5,2.2,4.2,"retina: 10.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (microvilli): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LCA5L,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000157653,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.334444,0.280088,0.208874,0,80,unavailable,1.9,0.9,0.7,"bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C9orf43,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000157703,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 47.3684% (minimum 75%, Missing); choroid plexus: 16.9811% (minimum 75%, Missing); colon: 69.2308% (minimum 70%, Missing); kidney: 40.0000% (minimum 75%, Missing); parathyroid gland: 31.0345% (minimum 70%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 36.7347% (minimum 75%, Missing); salivary gland: 31.5789% (minimum 70%, Missing)",0.07,-0.389655,-0.580189,0,80,unavailable,8.8,4,0.7,"choroid plexus: 8.8 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 3); salivary gland: 3.9 nTPM (protected, limit 3); retina: 3.1 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SVOPL,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000157884,True,compatible,,True,True,True,,0.225,0.288235,0.199153,0,80,unavailable,0.9,0.2,2.4,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CIB4,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000158402,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0204981,0.117757,0.00431034,0,8,partial,5.7,3.9,8.6,"thymus: 8.6 nTPM (manageable, limit 5); bone marrow: 5.7 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); lymph node: 3.1 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CDC25C,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000158423,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 58.2317% (minimum 75%, Missing)",0.268269,0.238575,-0.167683,0,80,unavailable,27.4,2.5,3.4,"choroid plexus: 27.4 nTPM (vital, limit 1); retina: 11 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RIBC1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000158497,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 59.0909% (minimum 75%, Missing); lymph node: 68.4211% (minimum 70%, Missing); thymus: 36.1111% (minimum 65%, Missing)",-0.288889,-0.0157895,-0.159091,0,80,unavailable,0.9,0.6,2.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HMHB1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000158525,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.286963,0.247826,0.214602,0,80,unavailable,1.2,1.8,2.2,"pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CPA5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000158553,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,POM121L2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000158639,True,compatible,,True,True,True,,0.346139,0.3,0.246139,0,2,partial,1,0.3,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PAGE5,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000158683,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.1538% (minimum 65%, Missing); basal ganglia: 70.5882% (minimum 75%, Missing); bone marrow: 54.5455% (minimum 75%, Missing); cerebellum: 75.0000% (minimum 75%, Missing); duodenum: 66.6667% (minimum 75%, Missing); heart muscle: 31.5789% (minimum 75%, Missing); hypothalamus: 75.0000% (minimum 75%, Missing); liver: 70.5882% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); retina: 41.3793% (minimum 75%, Missing); skeletal muscle: 30.7692% (minimum 75%, Missing); thymus: 50.0000% (minimum 65%, Missing); tongue: 32.4324% (minimum 70%, Missing)",-0.188462,-0.375676,-0.442308,0,80,unavailable,2.7,2.5,1.4,"skeletal muscle: 2.7 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PKD1L1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000158769,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.4003% (minimum 75%, Missing); bone marrow: 69.9001% (minimum 75%, Missing); colon: 49.0000% (minimum 70%, Missing); duodenum: 47.4347% (minimum 75%, Missing); esophagus: 37.0931% (minimum 70%, Missing); kidney: 55.5556% (minimum 75%, Missing); liver: 40.6977% (minimum 75%, Missing); lung: 42.9448% (minimum 75%, Missing); pancreas: 54.7486% (minimum 75%, Missing); parathyroid gland: 58.2640% (minimum 70%, Missing); pituitary gland: 72.8083% (minimum 75%, Missing); rectum: 49.4450% (minimum 70%, Missing); salivary gland: 50.5676% (minimum 70%, Missing); skin: 51.1482% (minimum 65%, Missing); small intestine: 44.1441% (minimum 75%, Missing); stomach: 48.8534% (minimum 70%, Missing); thyroid gland: 56.2572% (minimum 65%, Missing); urinary bladder: 49.3454% (minimum 70%, Missing)",-0.138518,-0.329069,-0.343023,0,6,partial,71.4,83.1,46.8,"esophagus: 83.1 nTPM (protected, limit 3); liver: 71.4 nTPM (vital, limit 1); lung: 65.1 nTPM (vital, limit 1); small intestine: 62 nTPM (vital, limit 1); duodenum: 54.3 nTPM (vital, limit 1); stomach: 51.3 nTPM (protected, limit 3); colon: 51 nTPM (protected, limit 3); urinary bladder: 50.3 nTPM (protected, limit 3); rectum: 50.1 nTPM (protected, limit 3); salivary gland: 47.9 nTPM (protected, limit 3); skin: 46.8 nTPM (manageable, limit 5); pancreas: 40.5 nTPM (vital, limit 1); kidney: 39.2 nTPM (vital, limit 1); thyroid gland: 38.1 nTPM (manageable, limit 5); parathyroid gland: 35.1 nTPM (protected, limit 3); adrenal gland: 23.7 nTPM (vital, limit 1); bone marrow: 21.1 nTPM (vital, limit 1); spleen: 21 nTPM (manageable, limit 5); pituitary gland: 18.3 nTPM (vital, limit 1); thymus: 16 nTPM (manageable, limit 5); lymph node: 12.9 nTPM (protected, limit 3); choroid plexus: 12.7 nTPM (vital, limit 1); heart muscle: 12.4 nTPM (vital, limit 1); smooth muscle: 8.7 nTPM (vital, limit 6); midbrain: 6.4 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 3); hippocampal formation: 5.8 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,F11R,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000158987,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.6587% (minimum 75%, Missing); bone marrow: 48.7603% (minimum 75%, Missing); cerebellum: 40.5498% (minimum 75%, Missing); cerebral cortex: 65.5556% (minimum 75%, Missing); hippocampal formation: 74.2138% (minimum 75%, Missing); hypothalamus: 71.9512% (minimum 75%, Missing); kidney: 74.6835% (minimum 75%, Missing); liver: 65.1934% (minimum 75%, Missing); lung: 63.7838% (minimum 75%, Missing); lymph node: 36.4198% (minimum 70%, Missing); midbrain: 74.2138% (minimum 75%, Missing); pancreas: 74.2138% (minimum 75%, Missing); parathyroid gland: 64.4809% (minimum 70%, Missing); rectum: 68.6047% (minimum 70%, Missing); retina: 59.8985% (minimum 75%, Missing); small intestine: 74.6835% (minimum 75%, Missing); spinal cord: 69.8225% (minimum 75%, Missing); spleen: 57.8431% (minimum 65%, Missing); thymus: 44.6970% (minimum 65%, Missing); urinary bladder: 68.6047% (minimum 70%, Missing)",-0.20303,-0.335802,-0.344502,0,2,partial,17.3,20.6,14.6,"lymph node: 20.6 nTPM (protected, limit 3); cerebellum: 17.3 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); bone marrow: 12.4 nTPM (vital, limit 1); spleen: 8.6 nTPM (manageable, limit 5); retina: 7.9 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); parathyroid gland: 6.5 nTPM (protected, limit 3); liver: 6.3 nTPM (vital, limit 1); cerebral cortex: 6.2 nTPM (vital, limit 1); rectum: 5.4 nTPM (protected, limit 3); urinary bladder: 5.4 nTPM (protected, limit 3); spinal cord: 5.1 nTPM (vital, limit 1); adrenal gland: 4.9 nTPM (vital, limit 1); colon: 4.8 nTPM (protected, limit 3); hypothalamus: 4.6 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); midbrain: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); small intestine: 4 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 3); salivary gland: 3.9 nTPM (protected, limit 3); smooth muscle: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); basal ganglia: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.4 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 3); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RAPGEF6,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000159079,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.1716% (minimum 75%, Missing); amygdala: 63.5789% (minimum 75%, Missing); basal ganglia: 64.5299% (minimum 75%, Missing); cerebellum: 55.2608% (minimum 75%, Missing); cerebral cortex: 63.9153% (minimum 75%, Missing); choroid plexus: 47.1507% (minimum 75%, Missing); hippocampal formation: 61.5698% (minimum 75%, Missing); hypothalamus: 58.0769% (minimum 75%, Missing); kidney: 62.2039% (minimum 75%, Missing); lung: 71.3105% (minimum 75%, Missing); midbrain: 66.8882% (minimum 75%, Missing); pancreas: 63.1799% (minimum 75%, Missing); pituitary gland: 55.9778% (minimum 75%, Missing); retina: 69.2661% (minimum 75%, Missing); salivary gland: 68.4032% (minimum 70%, Missing); small intestine: 73.0351% (minimum 75%, Missing); spinal cord: 68.7144% (minimum 75%, Missing); stomach: 68.0180% (minimum 70%, Missing)",0.000161464,-0.0198198,-0.278493,0,5,partial,67.7,29.8,32.5,"choroid plexus: 67.7 nTPM (vital, limit 1); cerebellum: 48.9 nTPM (vital, limit 1); pituitary gland: 47.5 nTPM (vital, limit 1); hypothalamus: 43.6 nTPM (vital, limit 1); hippocampal formation: 37.7 nTPM (vital, limit 1); kidney: 36.7 nTPM (vital, limit 1); pancreas: 35.2 nTPM (vital, limit 1); amygdala: 34.6 nTPM (vital, limit 1); cerebral cortex: 34.1 nTPM (vital, limit 1); skeletal muscle: 34 nTPM (vital, limit 6); basal ganglia: 33.2 nTPM (vital, limit 1); thyroid gland: 32.5 nTPM (manageable, limit 5); midbrain: 29.9 nTPM (vital, limit 1); esophagus: 29.8 nTPM (protected, limit 12); stomach: 28.4 nTPM (protected, limit 3); liver: 28.3 nTPM (vital, limit 6); adrenal gland: 28.2 nTPM (vital, limit 1); salivary gland: 27.9 nTPM (protected, limit 3); spinal cord: 27.5 nTPM (vital, limit 1); skin: 26.9 nTPM (manageable, limit 5); retina: 26.8 nTPM (vital, limit 1); heart muscle: 25.9 nTPM (vital, limit 6); colon: 25.6 nTPM (protected, limit 3); lung: 24.3 nTPM (vital, limit 1); urinary bladder: 23.9 nTPM (protected, limit 3); adipose tissue: 22.6 nTPM (manageable, limit 5); small intestine: 22.3 nTPM (vital, limit 1); parathyroid gland: 20.5 nTPM (protected, limit 12); lymph node: 16.1 nTPM (protected, limit 3); thymus: 15.6 nTPM (manageable, limit 5); bone marrow: 13.9 nTPM (vital, limit 6); duodenum: 13.6 nTPM (vital, limit 1); rectum: 13.3 nTPM (protected, limit 3); tongue: 11.3 nTPM (protected, limit 3); smooth muscle: 11 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP298,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000159082,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 60.0000% (minimum 75%, Missing); amygdala: 34.7368% (minimum 75%, Missing); basal ganglia: 29.5522% (minimum 75%, Missing); bone marrow: 29.6407% (minimum 75%, Missing); cerebellum: 25.8486% (minimum 75%, Missing); cerebral cortex: 19.3738% (minimum 75%, Missing); choroid plexus: 52.1053% (minimum 75%, Missing); colon: 64.2857% (minimum 70%, Missing); duodenum: 72.2628% (minimum 75%, Missing); hippocampal formation: 28.2051% (minimum 75%, Missing); hypothalamus: 27.8090% (minimum 75%, Missing); kidney: 58.2353% (minimum 75%, Missing); lung: 55.9322% (minimum 75%, Missing); lymph node: 61.8750% (minimum 70%, Missing); midbrain: 31.4286% (minimum 75%, Missing); pancreas: 67.8082% (minimum 75%, Missing); pituitary gland: 42.4893% (minimum 75%, Missing); rectum: 65.1316% (minimum 70%, Missing); retina: 17.4296% (minimum 75%, Missing); skeletal muscle: 57.2254% (minimum 75%, Missing); small intestine: 61.8750% (minimum 75%, Missing); smooth muscle: 67.3469% (minimum 75%, Missing); spinal cord: 47.1429% (minimum 75%, Missing); spleen: 56.2500% (minimum 65%, Missing); stomach: 67.3469% (minimum 70%, Missing); thymus: 58.9286% (minimum 65%, Missing); thyroid gland: 58.2353% (minimum 65%, Missing); tongue: 61.4907% (minimum 70%, Missing); urinary bladder: 64.7059% (minimum 70%, Missing)",-0.0875,-0.0850932,-0.575704,0,6,partial,46.9,8.1,7.7,"retina: 46.9 nTPM (vital, limit 1); cerebral cortex: 41.2 nTPM (vital, limit 1); cerebellum: 28.4 nTPM (vital, limit 1); hypothalamus: 25.7 nTPM (vital, limit 1); hippocampal formation: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); bone marrow: 23.5 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); amygdala: 18.6 nTPM (vital, limit 1); pituitary gland: 13.4 nTPM (vital, limit 1); spinal cord: 11.1 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); lung: 7.8 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); skeletal muscle: 7.4 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); kidney: 7.1 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); adrenal gland: 6.6 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 6); tongue: 6.2 nTPM (protected, limit 3); small intestine: 6.1 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 3); colon: 5.5 nTPM (protected, limit 3); urinary bladder: 5.4 nTPM (protected, limit 3); rectum: 5.3 nTPM (protected, limit 3); smooth muscle: 4.8 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 3); pancreas: 4.7 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: Medium (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / synaptic glomeruli - capsule: Medium (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SYNJ1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000159131,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.0193% (minimum 65%, Missing); adrenal gland: 59.2516% (minimum 75%, Missing); amygdala: 71.4286% (minimum 75%, Missing); basal ganglia: 69.5122% (minimum 75%, Missing); bone marrow: 60.6383% (minimum 75%, Missing); cerebellum: 73.2648% (minimum 75%, Missing); cerebral cortex: 60.6383% (minimum 75%, Missing); choroid plexus: 72.7041% (minimum 75%, Missing); colon: 55.9921% (minimum 70%, Missing); duodenum: 57.0000% (minimum 75%, Missing); esophagus: 54.1825% (minimum 70%, Missing); heart muscle: 58.7629% (minimum 70%, Approved); hippocampal formation: 73.8342% (minimum 75%, Missing); hypothalamus: 71.4286% (minimum 75%, Missing); kidney: 58.5216% (minimum 75%, Missing); liver: 49.8252% (minimum 75%, Missing); lung: 64.7727% (minimum 75%, Missing); lymph node: 49.1379% (minimum 70%, Missing); midbrain: 69.3431% (minimum 75%, Missing); pancreas: 56.7729% (minimum 75%, Missing); parathyroid gland: 59.7484% (minimum 70%, Missing); pituitary gland: 69.6822% (minimum 75%, Missing); rectum: 50.3534% (minimum 70%, Missing); retina: 58.6420% (minimum 75%, Missing); salivary gland: 63.6161% (minimum 70%, Missing); skeletal muscle: 50.4425% (minimum 75%, Missing); skin: 62.9139% (minimum 65%, Missing); small intestine: 60.2537% (minimum 75%, Missing); smooth muscle: 52.9740% (minimum 75%, Missing); spinal cord: 68.1818% (minimum 75%, Missing); spleen: 59.3750% (minimum 65%, Missing); stomach: 59.7484% (minimum 70%, Missing); thymus: 45.9677% (minimum 65%, Missing); thyroid gland: 58.5216% (minimum 65%, Missing); tongue: 57.6923% (minimum 70%, Missing); urinary bladder: 47.8992% (minimum 70%, Missing)",-0.190323,-0.221008,-0.251748,0,1,partial,28.7,31,33.5,"thymus: 33.5 nTPM (manageable, limit 5); urinary bladder: 31 nTPM (protected, limit 3); lymph node: 29.5 nTPM (protected, limit 3); liver: 28.7 nTPM (vital, limit 1); rectum: 28.1 nTPM (protected, limit 3); skeletal muscle: 28 nTPM (vital, limit 1); smooth muscle: 25.3 nTPM (vital, limit 1); esophagus: 24.1 nTPM (protected, limit 3); adipose tissue: 23.3 nTPM (manageable, limit 5); colon: 22.4 nTPM (protected, limit 3); pancreas: 21.7 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); tongue: 20.9 nTPM (protected, limit 3); thyroid gland: 20.2 nTPM (manageable, limit 5); kidney: 20.2 nTPM (vital, limit 1); retina: 20.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 2); adrenal gland: 19.6 nTPM (vital, limit 1); spleen: 19.5 nTPM (manageable, limit 5); parathyroid gland: 19.2 nTPM (protected, limit 3); stomach: 19.2 nTPM (protected, limit 3); small intestine: 18.8 nTPM (vital, limit 1); cerebral cortex: 18.5 nTPM (vital, limit 1); bone marrow: 18.5 nTPM (vital, limit 1); skin: 16.8 nTPM (manageable, limit 5); salivary gland: 16.3 nTPM (protected, limit 3); lung: 15.5 nTPM (vital, limit 1); spinal cord: 13.3 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); basal ganglia: 12.5 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); choroid plexus: 10.7 nTPM (vital, limit 1); cerebellum: 10.4 nTPM (vital, limit 1); hippocampal formation: 10.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GART,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000159217,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.246429,0.0653846,0,4,partial,1.2,0.3,0,"kidney: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IGF2BP1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000159224,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 62.5000% (minimum 70%, Missing); duodenum: 0.1982% (minimum 75%, Missing); small intestine: 0.5453% (minimum 75%, Missing); stomach: 29.4118% (minimum 55%, Enhanced)",0.183333,-0.255882,-0.748018,0,10,partial,251.8,1.2,0.1,"duodenum: 251.8 nTPM (vital, limit 1); small intestine: 91.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),74,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GIP,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000159289,True,compatible,,True,True,True,,0.35,0.3,0.219822,0,1,partial,2.2,0,0.1,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GOLGA6A,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,True,True,True,False,gained,selectivity_revised
ENSG00000159374,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 72.4138% (minimum 75%, Missing)",0.19,0.175,-0.0258621,0,80,unavailable,2.4,0.9,1.2,"bone marrow: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,M1AP,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000159495,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 66.6667% (minimum 70%, Missing); skeletal muscle: 72.7273% (minimum 75%, Missing)",0.35,-0.0333333,-0.0227273,0,80,unavailable,0.3,0.4,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TGM7,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000159625,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345546,0.284581,0.0383598,0,80,unavailable,12,0.7,0.2,"choroid plexus: 12 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DRC7,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000159708,True,compatible,,True,True,True,,0.35,0.3,0.241329,0,3,partial,4.8,0.5,0.1,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRRC36,current_adaptive,True,False,True,False,10.1371/journal.pgen.1011734,Loriot 2025 · preferential,False,True,True,True,False,gained,selectivity_revised
ENSG00000159761,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.305556,0.237046,0.137615,0,4,partial,10,4,3.4,"cerebellum: 10 nTPM (vital, limit 6); choroid plexus: 4.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C16orf86,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000159882,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.1509% (minimum 65%, Missing); adrenal gland: 61.8182% (minimum 75%, Missing); amygdala: 73.9130% (minimum 75%, Missing); basal ganglia: 70.8333% (minimum 75%, Missing); bone marrow: 51.5152% (minimum 75%, Missing); cerebellum: 48.5714% (minimum 75%, Missing); cerebral cortex: 70.8333% (minimum 75%, Missing); choroid plexus: 61.8182% (minimum 75%, Missing); colon: 64.1509% (minimum 70%, Missing); duodenum: 73.9130% (minimum 75%, Missing); heart muscle: 65.3846% (minimum 75%, Missing); hippocampal formation: 73.9130% (minimum 75%, Missing); hypothalamus: 72.3404% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 62.9630% (minimum 75%, Missing); lung: 59.6491% (minimum 75%, Missing); lymph node: 50.7463% (minimum 70%, Missing); midbrain: 73.9130% (minimum 75%, Missing); pancreas: 70.8333% (minimum 75%, Missing); parathyroid gland: 56.6667% (minimum 70%, Missing); pituitary gland: 56.6667% (minimum 75%, Missing); rectum: 64.1509% (minimum 70%, Missing); retina: 43.0380% (minimum 75%, Missing); salivary gland: 65.3846% (minimum 70%, Missing); skin: 54.8387% (minimum 65%, Missing); small intestine: 59.6491% (minimum 75%, Missing); smooth muscle: 65.3846% (minimum 75%, Missing); spinal cord: 70.8333% (minimum 75%, Missing); spleen: 47.2222% (minimum 65%, Missing); stomach: 65.3846% (minimum 70%, Missing); thymus: 46.5753% (minimum 65%, Missing); thyroid gland: 53.9683% (minimum 65%, Missing); tongue: 65.3846% (minimum 70%, Missing); urinary bladder: 62.9630% (minimum 70%, Missing)",-0.184247,-0.192537,-0.31962,0,80,unavailable,4.5,3.3,3.9,"retina: 4.5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); lymph node: 3.3 nTPM (protected, limit 3); bone marrow: 3.2 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF230,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000159905,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.6923% (minimum 75%, Missing); cerebellum: 37.5000% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); choroid plexus: 68.1818% (minimum 75%, Missing); colon: 68.1818% (minimum 70%, Missing); esophagus: 65.2174% (minimum 70%, Missing); heart muscle: 55.5556% (minimum 75%, Missing); hypothalamus: 68.1818% (minimum 75%, Missing); kidney: 60.0000% (minimum 75%, Missing); liver: 57.6923% (minimum 75%, Missing); lung: 62.5000% (minimum 75%, Missing); pancreas: 68.1818% (minimum 75%, Missing); parathyroid gland: 40.5405% (minimum 70%, Missing); pituitary gland: 62.5000% (minimum 75%, Missing); rectum: 65.2174% (minimum 70%, Missing); retina: 34.0909% (minimum 75%, Missing); salivary gland: 68.1818% (minimum 70%, Missing); skin: 57.6923% (minimum 65%, Missing); small intestine: 68.1818% (minimum 75%, Missing); smooth muscle: 53.5714% (minimum 75%, Missing); spinal cord: 65.2174% (minimum 75%, Missing); spleen: 60.0000% (minimum 65%, Missing); stomach: 65.2174% (minimum 70%, Missing); thymus: 57.6923% (minimum 65%, Missing); thyroid gland: 46.8750% (minimum 65%, Missing); tongue: 68.1818% (minimum 70%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.18125,-0.294595,-0.409091,0,80,unavailable,2.9,2.2,1.7,"retina: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF221,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000159915,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.231988,0.130409,0.00132275,0,80,unavailable,4.7,2.9,1.9,"retina: 4.7 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF233,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000160062,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.8557% (minimum 65%, Missing); adrenal gland: 73.1707% (minimum 75%, Missing); cerebellum: 65.9341% (minimum 75%, Missing); cerebral cortex: 73.1707% (minimum 75%, Missing); colon: 68.1818% (minimum 70%, Missing); esophagus: 64.5161% (minimum 70%, Missing); heart muscle: 72.2892% (minimum 75%, Missing); kidney: 72.2892% (minimum 75%, Missing); lung: 68.9655% (minimum 75%, Missing); pancreas: 69.7674% (minimum 75%, Missing); parathyroid gland: 63.1579% (minimum 70%, Missing); rectum: 67.4157% (minimum 70%, Missing); skeletal muscle: 69.7674% (minimum 75%, Missing); smooth muscle: 55.0459% (minimum 75%, Missing); stomach: 65.9341% (minimum 70%, Missing); thyroid gland: 53.0973% (minimum 65%, Missing); tongue: 50.4202% (minimum 70%, Missing); urinary bladder: 62.5000% (minimum 70%, Missing)",-0.119027,-0.195798,-0.199541,0,2,partial,4.9,5.9,5.3,"tongue: 5.9 nTPM (protected, limit 3); thyroid gland: 5.3 nTPM (manageable, limit 5); smooth muscle: 4.9 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 3); parathyroid gland: 3.5 nTPM (protected, limit 3); esophagus: 3.3 nTPM (protected, limit 3); cerebellum: 3.1 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); lung: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZBTB8A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000160161,True,compatible,,True,True,True,,0.207143,0.247368,0.09375,0,80,unavailable,1,0.3,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CILP2,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,True,True,True,True,gained,selectivity_revised
ENSG00000160207,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.345745,0.295745,0.156977,0,4,partial,2.4,0.7,0.5,"cerebral cortex: 2.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HSF2BP,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000160318,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.222255,0.202893,0.0714286,0,80,unavailable,9.5,4.7,6.4,"bone marrow: 9.5 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); spleen: 6.4 nTPM (manageable, limit 5); cerebral cortex: 6.2 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.8 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); cerebellum: 4.9 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 3); liver: 4.6 nTPM (vital, limit 1); colon: 4.5 nTPM (protected, limit 3); adrenal gland: 4.4 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 3); small intestine: 4.2 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CLDND2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000160321,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 74.5455% (minimum 75%, Missing); colon: 63.5659% (minimum 70%, Missing); heart muscle: 42.9319% (minimum 75%, Missing); hippocampal formation: 67.2131% (minimum 75%, Missing); hypothalamus: 48.5207% (minimum 75%, Missing); kidney: 65.0794% (minimum 75%, Missing); midbrain: 50.6173% (minimum 75%, Missing); parathyroid gland: 39.0476% (minimum 70%, Missing); pituitary gland: 54.3046% (minimum 75%, Missing); smooth muscle: 58.5714% (minimum 75%, Missing); spinal cord: 65.0794% (minimum 75%, Missing); thyroid gland: 52.2293% (minimum 65%, Missing)",-0.127707,-0.309524,-0.320681,0,80,unavailable,10.9,12.8,7.5,"parathyroid gland: 12.8 nTPM (protected, limit 3); heart muscle: 10.9 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); midbrain: 8 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); pituitary gland: 6.9 nTPM (vital, limit 1); smooth muscle: 5.8 nTPM (vital, limit 1); colon: 4.7 nTPM (protected, limit 3); kidney: 4.4 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 3); cerebral cortex: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF208,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000160352,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 67.7725% (minimum 75%, Missing); cerebellum: 69.4175% (minimum 75%, Missing); thyroid gland: 50.7092% (minimum 65%, Missing)",-0.142908,0.0371134,-0.0722749,0,80,unavailable,6.8,5.1,13.9,"thyroid gland: 13.9 nTPM (manageable, limit 5); bone marrow: 6.8 nTPM (vital, limit 1); skin: 6.4 nTPM (manageable, limit 5); cerebellum: 6.3 nTPM (vital, limit 1); thymus: 5.5 nTPM (manageable, limit 5); esophagus: 5.1 nTPM (protected, limit 3); lymph node: 4.7 nTPM (protected, limit 3); adrenal gland: 4.3 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.7 nTPM (vital, limit 1); rectum: 3.5 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF714,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000160396,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 66.6667% (minimum 75%, Missing)",0.338764,0.272376,-0.0833333,0,80,unavailable,8.8,0.5,0.2,"basal ganglia: 8.8 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HIPK4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000160471,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.314912,0.231217,0.237654,0,80,unavailable,1.1,6.5,3.2,"colon: 6.5 nTPM (protected, limit 3); rectum: 4.7 nTPM (protected, limit 3); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,COX6B2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000160505,True,compatible,,True,True,True,,0.321429,0.109524,0.221429,0,80,unavailable,0.2,1.6,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NLRP4,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000160838,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 68.9944% (minimum 75%, Missing)",0.341968,0.3,-0.0600559,0,80,unavailable,11.1,0,0.2,"choroid plexus: 11.1 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRRC71,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000160882,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 0.1119% (minimum 75%, Missing); cerebellum: 48.7805% (minimum 65%, Supported)",0.35,0.154717,-0.748881,0,0,routine_complete,3571.8,1.3,0.3,"adrenal gland: 3571.8 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 3)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CYP11B1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000160886,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333146,0.1931,0.185829,0,2,partial,5.2,12.1,6.6,"esophagus: 12.1 nTPM (protected, limit 12); midbrain: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LY6K,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000160994,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,1,partial,0.2,0,0,,bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); rectum / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder / glandular cells; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEKTL1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000161036,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.319214,0.281298,0.189937,0,2,partial,26.8,8.7,23.7,"cerebellum: 26.8 nTPM (vital, limit 6); pituitary gland: 17.1 nTPM (vital, limit 1); small intestine: 16.6 nTPM (vital, limit 6); adrenal gland: 16.2 nTPM (vital, limit 6); bone marrow: 14.8 nTPM (vital, limit 6); liver: 14.6 nTPM (vital, limit 6); hypothalamus: 13.8 nTPM (vital, limit 1); cerebral cortex: 13.8 nTPM (vital, limit 6); basal ganglia: 13.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 6); hippocampal formation: 12.5 nTPM (vital, limit 1); amygdala: 11.7 nTPM (vital, limit 1); choroid plexus: 11 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 6); midbrain: 10.3 nTPM (vital, limit 1); lung: 9.8 nTPM (vital, limit 1); heart muscle: 9.4 nTPM (vital, limit 6); pancreas: 9 nTPM (vital, limit 6); spinal cord: 8.9 nTPM (vital, limit 1); thymus: 8.5 nTPM (manageable, limit 5); tongue: 5.1 nTPM (protected, limit 3); retina: 3.3 nTPM (vital, limit 1)",lung / macrophages: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRWD1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000161040,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 71.6981% (minimum 75%, Missing); choroid plexus: 73.0769% (minimum 75%, Missing); retina: 59.3750% (minimum 75%, Missing); stomach: 43.6782% (minimum 70%, Missing)",0.176087,-0.263218,-0.15625,0,2,partial,2.6,4.9,0.8,"stomach: 4.9 nTPM (protected, limit 3); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FBXL13,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000161180,True,compatible,,True,True,True,,0.323064,0.266555,0.229661,0,80,unavailable,0.6,1,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC116,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000161217,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 41.8426% (minimum 65%, Missing); adrenal gland: 47.9121% (minimum 75%, Missing); amygdala: 62.6437% (minimum 75%, Missing); basal ganglia: 62.6437% (minimum 75%, Missing); bone marrow: 32.6347% (minimum 75%, Missing); cerebellum: 63.0058% (minimum 75%, Missing); cerebral cortex: 58.2888% (minimum 75%, Missing); choroid plexus: 57.8249% (minimum 75%, Missing); colon: 46.7811% (minimum 70%, Missing); duodenum: 27.1144% (minimum 75%, Missing); esophagus: 42.1663% (minimum 70%, Missing); heart muscle: 32.7327% (minimum 75%, Missing); hippocampal formation: 63.5569% (minimum 75%, Missing); hypothalamus: 61.5819% (minimum 75%, Missing); kidney: 55.1899% (minimum 75%, Missing); liver: 52.1531% (minimum 75%, Missing); lung: 50.0000% (minimum 75%, Missing); lymph node: 49.4331% (minimum 70%, Missing); midbrain: 58.7601% (minimum 75%, Missing); pancreas: 57.2178% (minimum 75%, Missing); parathyroid gland: 49.8856% (minimum 70%, Missing); pituitary gland: 63.3721% (minimum 75%, Missing); rectum: 49.5455% (minimum 70%, Missing); retina: 61.0644% (minimum 75%, Missing); salivary gland: 53.8272% (minimum 70%, Missing); skeletal muscle: 23.4409% (minimum 75%, Missing); skin: 34.2767% (minimum 65%, Missing); small intestine: 31.3669% (minimum 75%, Missing); smooth muscle: 49.5455% (minimum 75%, Missing); spinal cord: 58.1333% (minimum 75%, Missing); spleen: 46.2845% (minimum 65%, Missing); stomach: 48.0176% (minimum 70%, Missing); thymus: 55.0505% (minimum 65%, Missing); thyroid gland: 56.7708% (minimum 65%, Missing); tongue: 35.0482% (minimum 70%, Missing); urinary bladder: 51.9048% (minimum 70%, Missing)",-0.307233,-0.349518,-0.515591,0,1,partial,71.2,40.4,41.8,"skeletal muscle: 71.2 nTPM (vital, limit 1); duodenum: 58.6 nTPM (vital, limit 1); small intestine: 47.7 nTPM (vital, limit 1); bone marrow: 45 nTPM (vital, limit 1); heart muscle: 44.8 nTPM (vital, limit 1); skin: 41.8 nTPM (manageable, limit 5); tongue: 40.4 nTPM (protected, limit 3); adipose tissue: 30.3 nTPM (manageable, limit 5); esophagus: 29.9 nTPM (protected, limit 3); spleen: 25.3 nTPM (manageable, limit 5); colon: 24.8 nTPM (protected, limit 3); adrenal gland: 23.7 nTPM (vital, limit 1); stomach: 23.6 nTPM (protected, limit 3); lymph node: 22.3 nTPM (protected, limit 3); smooth muscle: 22.2 nTPM (vital, limit 1); rectum: 22.2 nTPM (protected, limit 3); parathyroid gland: 21.9 nTPM (protected, limit 3); lung: 21.8 nTPM (vital, limit 1); urinary bladder: 20.2 nTPM (protected, limit 3); liver: 20 nTPM (vital, limit 1); salivary gland: 18.7 nTPM (protected, limit 3); thymus: 17.8 nTPM (manageable, limit 5); kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 16.6 nTPM (manageable, limit 5); pancreas: 16.3 nTPM (vital, limit 1); choroid plexus: 15.9 nTPM (vital, limit 1); spinal cord: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.6 nTPM (vital, limit 1); midbrain: 15.3 nTPM (vital, limit 1); retina: 13.9 nTPM (vital, limit 1); hypothalamus: 13.6 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); amygdala: 13 nTPM (vital, limit 1); cerebellum: 12.8 nTPM (vital, limit 1); pituitary gland: 12.6 nTPM (vital, limit 1); hippocampal formation: 12.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCYT1A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000161405,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 23.6842% (minimum 75%, Missing); colon: 36.0000% (minimum 70%, Missing); duodenum: 34.6154% (minimum 75%, Missing); esophagus: 54.5455% (minimum 55%, Enhanced); liver: 48.6486% (minimum 60%, Enhanced); lung: 37.5000% (minimum 75%, Missing); lymph node: 4.8128% (minimum 70%, Missing); rectum: 37.5000% (minimum 70%, Missing); salivary gland: 46.1538% (minimum 55%, Enhanced); small intestine: 13.2353% (minimum 75%, Missing); spleen: 7.6271% (minimum 65%, Missing); stomach: 23.0769% (minimum 55%, Enhanced); thymus: 7.4380% (minimum 65%, Missing); urinary bladder: 29.5082% (minimum 55%, Enhanced)",-0.57562,-0.651872,-0.617647,0,8,partial,11.8,35.6,22.4,"lymph node: 35.6 nTPM (protected, limit 3); thymus: 22.4 nTPM (manageable, limit 5); spleen: 21.8 nTPM (manageable, limit 5); small intestine: 11.8 nTPM (vital, limit 1); bone marrow: 5.8 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); lung: 3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); colon / mucosal lymphoid cells: High (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / non-germinal center cells: High (Enhanced); rectum / mucosal lymphoid cells: High (Enhanced); spleen / cells in white pulp: High (Enhanced),73,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / non-germinal center cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IKZF3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000161594,True,compatible,,True,True,True,,0.35,0.3,0.244643,0,2,partial,0.7,0.8,0.4,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KLHL10,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000161609,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.0717054,0,1,partial,11.5,0,0,"cerebellum: 11.5 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KASH5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000161652,True,compatible,,True,True,True,,0.34841,0.3,0.24841,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IZUMO2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000161654,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.8352% (minimum 60%, Approved); adrenal gland: 53.5088% (minimum 75%, Missing); amygdala: 54.8315% (minimum 75%, Missing); basal ganglia: 59.3674% (minimum 75%, Missing); bone marrow: 45.5224% (minimum 75%, Missing); cerebellum: 59.6577% (minimum 75%, Missing); cerebral cortex: 53.8631% (minimum 75%, Missing); choroid plexus: 60.3960% (minimum 75%, Missing); colon: 56.0920% (minimum 70%, Missing); duodenum: 59.3674% (minimum 75%, Missing); esophagus: 47.1954% (minimum 70%, Missing); heart muscle: 52.6998% (minimum 75%, Missing); hippocampal formation: 56.3510% (minimum 75%, Missing); hypothalamus: 52.4731% (minimum 75%, Missing); kidney: 54.7085% (minimum 75%, Missing); liver: 46.1248% (minimum 75%, Missing); lung: 59.9509% (minimum 75%, Missing); lymph node: 54.5861% (minimum 70%, Missing); midbrain: 55.0790% (minimum 75%, Missing); pancreas: 51.2605% (minimum 75%, Missing); parathyroid gland: 53.9823% (minimum 70%, Missing); pituitary gland: 63.8743% (minimum 75%, Missing); rectum: 51.5856% (minimum 70%, Missing); retina: 44.6069% (minimum 75%, Missing); salivary gland: 58.0952% (minimum 70%, Missing); skeletal muscle: 40.5316% (minimum 75%, Missing); skin: 60.0985% (minimum 65%, Missing); small intestine: 59.8039% (minimum 75%, Missing); smooth muscle: 55.4545% (minimum 75%, Missing); spinal cord: 56.7442% (minimum 75%, Missing); spleen: 59.2233% (minimum 65%, Missing); stomach: 55.8352% (minimum 70%, Missing); thymus: 55.7078% (minimum 65%, Missing); thyroid gland: 57.9572% (minimum 65%, Missing); tongue: 51.6949% (minimum 70%, Missing); urinary bladder: 52.5862% (minimum 70%, Missing)",-0.0929224,-0.228046,-0.344684,0,2,partial,35.8,27.3,19.4,"skeletal muscle: 35.8 nTPM (vital, limit 1); retina: 30.3 nTPM (vital, limit 1); bone marrow: 29.2 nTPM (vital, limit 1); liver: 28.5 nTPM (vital, limit 1); esophagus: 27.3 nTPM (protected, limit 3); pancreas: 23.2 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 3); tongue: 22.8 nTPM (protected, limit 3); hypothalamus: 22.1 nTPM (vital, limit 1); urinary bladder: 22 nTPM (protected, limit 3); heart muscle: 21.9 nTPM (vital, limit 1); adrenal gland: 21.2 nTPM (vital, limit 1); cerebral cortex: 20.9 nTPM (vital, limit 1); parathyroid gland: 20.8 nTPM (protected, limit 3); lymph node: 20.3 nTPM (protected, limit 3); kidney: 20.2 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); midbrain: 19.9 nTPM (vital, limit 1); smooth muscle: 19.6 nTPM (vital, limit 1); thymus: 19.4 nTPM (manageable, limit 5); adipose tissue: 19.3 nTPM (manageable, limit 10); stomach: 19.3 nTPM (protected, limit 3); colon: 19.1 nTPM (protected, limit 3); hippocampal formation: 18.9 nTPM (vital, limit 1); spinal cord: 18.6 nTPM (vital, limit 1); thyroid gland: 17.7 nTPM (manageable, limit 5); salivary gland: 17.6 nTPM (protected, limit 3); spleen: 16.8 nTPM (manageable, limit 5); duodenum: 16.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebellum: 16.5 nTPM (vital, limit 1); small intestine: 16.4 nTPM (vital, limit 1); lung: 16.3 nTPM (vital, limit 1); skin: 16.2 nTPM (manageable, limit 5); choroid plexus: 16 nTPM (vital, limit 1); pituitary gland: 13.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LSM12,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000161798,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"salivary gland: 26.3068% (minimum 70%, Missing)",0.164512,-0.436932,0.185442,0,2,partial,14.9,604.8,109,"salivary gland: 604.8 nTPM (protected, limit 3); skin: 109 nTPM (manageable, limit 30); stomach: 51 nTPM (protected, limit 3); esophagus: 16 nTPM (protected, limit 12); duodenum: 14.9 nTPM (vital, limit 1); lung: 7.4 nTPM (vital, limit 6); basal ganglia: 5.6 nTPM (vital, limit 1); midbrain: 4.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); salivary gland / glandular cells: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; salivary gland / glandular cells; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AQP5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000161850,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 25.0000% (minimum 50%, Enhanced); skin: 0.8065% (minimum 50%, Enhanced)",-0.491935,0.3,0.25,0,2,partial,0,0,12.3,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in cuticle; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KRT82,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000161860,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.285018,0.3,0.198718,0,1,partial,3.2,1.1,1.8,"retina: 1.4 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SYCE2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000161973,True,compatible,,True,True,True,,0.34784,0.29784,0.24784,0,80,unavailable,0.2,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC42,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000162039,True,compatible,,True,True,True,,0.320696,0.296241,0.224265,0,80,unavailable,0.7,0.1,0.8,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MEIOB,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,True,True,True,True,gained,selectivity_revised
ENSG00000162062,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 75.0000% (minimum 75%, Missing); bone marrow: 54.5455% (minimum 70%, Approved); lymph node: 69.5652% (minimum 70%, Missing)",0.0456522,-0.00434783,-0.154545,0,3,partial,4,2.2,2.1,"bone marrow: 4 nTPM (vital, limit 2); basal ganglia: 1.6 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEDC2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000162129,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.302889,0.234612,0.164676,0,3,partial,10,7.5,5.3,"liver: 10 nTPM (vital, limit 1); bone marrow: 9 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 3); cerebral cortex: 6.8 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); tongue: 6 nTPM (protected, limit 3); pancreas: 5.6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); heart muscle: 5.4 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); smooth muscle: 5.1 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); duodenum: 3.5 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); esophagus: 3.4 nTPM (protected, limit 3); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); urinary bladder: 3.2 nTPM (protected, limit 3); cerebellum: 3.2 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); hippocampal formation: 3.1 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 3); choroid plexus: 2.9 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CLPB,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000162148,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 63.6872% (minimum 75%, Missing)",0.285385,0.236345,-0.113128,0,14,partial,52,7.1,11.1,"choroid plexus: 52 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); hypothalamus: 14.1 nTPM (vital, limit 1); pituitary gland: 13.6 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 6); liver: 7.5 nTPM (vital, limit 6); cerebral cortex: 7.1 nTPM (vital, limit 6); cerebellum: 7 nTPM (vital, limit 6); kidney: 6.3 nTPM (vital, limit 6); thymus: 6.3 nTPM (manageable, limit 5); colon: 6.2 nTPM (protected, limit 3); midbrain: 5.6 nTPM (vital, limit 1); spinal cord: 5.2 nTPM (vital, limit 1); small intestine: 4.8 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),82,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Microvilli; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SAXO4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000162300,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.6623% (minimum 65%, Missing); adrenal gland: 49.2754% (minimum 75%, Missing); amygdala: 52.1295% (minimum 75%, Missing); basal ganglia: 49.9184% (minimum 75%, Missing); bone marrow: 51.4286% (minimum 75%, Missing); cerebellum: 57.1963% (minimum 75%, Missing); cerebral cortex: 52.2184% (minimum 75%, Missing); choroid plexus: 48.1132% (minimum 75%, Missing); colon: 50.9151% (minimum 70%, Missing); duodenum: 63.7500% (minimum 75%, Missing); esophagus: 51.2563% (minimum 70%, Missing); heart muscle: 50.7463% (minimum 75%, Missing); hippocampal formation: 51.3423% (minimum 75%, Missing); hypothalamus: 55.0360% (minimum 75%, Missing); kidney: 52.9412% (minimum 75%, Missing); liver: 49.0385% (minimum 75%, Missing); lung: 59.6491% (minimum 75%, Missing); midbrain: 49.7561% (minimum 75%, Missing); pancreas: 49.5948% (minimum 75%, Missing); parathyroid gland: 66.9584% (minimum 70%, Missing); pituitary gland: 43.6519% (minimum 75%, Missing); salivary gland: 50.5785% (minimum 70%, Missing); skeletal muscle: 45.6036% (minimum 75%, Missing); skin: 47.2952% (minimum 65%, Missing); small intestine: 52.8497% (minimum 75%, Missing); smooth muscle: 71.4953% (minimum 75%, Missing); spinal cord: 50.4119% (minimum 75%, Missing); spleen: 55.2347% (minimum 65%, Missing); stomach: 50.9151% (minimum 70%, Missing); thyroid gland: 53.7786% (minimum 65%, Missing); tongue: 60.9562% (minimum 70%, Missing); urinary bladder: 50.4119% (minimum 70%, Missing)",-0.177048,-0.195881,-0.313481,0,7,partial,39.5,30.1,34.1,"pituitary gland: 39.5 nTPM (vital, limit 1); skeletal muscle: 36.5 nTPM (vital, limit 1); skin: 34.1 nTPM (manageable, limit 5); choroid plexus: 33 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); adrenal gland: 31.5 nTPM (vital, limit 1); pancreas: 31.1 nTPM (vital, limit 1); midbrain: 30.9 nTPM (vital, limit 1); basal ganglia: 30.7 nTPM (vital, limit 1); spinal cord: 30.1 nTPM (vital, limit 1); urinary bladder: 30.1 nTPM (protected, limit 3); salivary gland: 29.9 nTPM (protected, limit 3); adipose tissue: 29.8 nTPM (manageable, limit 5); heart muscle: 29.7 nTPM (vital, limit 1); stomach: 29.5 nTPM (protected, limit 3); colon: 29.5 nTPM (protected, limit 3); esophagus: 29.1 nTPM (protected, limit 3); hippocampal formation: 29 nTPM (vital, limit 1); bone marrow: 28.9 nTPM (vital, limit 1); amygdala: 28.1 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 1); small intestine: 27.3 nTPM (vital, limit 1); kidney: 27.2 nTPM (vital, limit 1); thyroid gland: 26.3 nTPM (manageable, limit 5); hypothalamus: 25 nTPM (vital, limit 1); spleen: 24.8 nTPM (manageable, limit 5); cerebellum: 22.9 nTPM (vital, limit 1); lung: 20.7 nTPM (vital, limit 1); tongue: 19.6 nTPM (protected, limit 3); duodenum: 17.4 nTPM (vital, limit 1); parathyroid gland: 15.1 nTPM (protected, limit 3); smooth muscle: 12.2 nTPM (vital, limit 1); lymph node: 11.6 nTPM (protected, limit 3); thymus: 10.7 nTPM (manageable, limit 5); rectum: 8.8 nTPM (protected, limit 3); retina: 7.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZFPL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000162526,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 72.5877% (minimum 75%, Missing)",0.227984,0.199457,-0.0241228,0,80,unavailable,12.5,3.7,4.6,"bone marrow: 12.5 nTPM (vital, limit 1); cerebellum: 5.4 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); small intestine: 3.9 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 3); duodenum: 3.3 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TSSK3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000162543,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 67.5562% (minimum 75%, Missing)",0.250749,0.137979,-0.0744382,0,2,partial,23.1,9.3,5.3,"choroid plexus: 23.1 nTPM (vital, limit 1); colon: 9.3 nTPM (protected, limit 3); liver: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); lung: 5.1 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 3); rectum: 4.6 nTPM (protected, limit 3); esophagus: 3.9 nTPM (protected, limit 3); heart muscle: 3.4 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,UBXN10,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000162571,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.321429,0.287893,0.183638,0,80,unavailable,2.9,0.5,1.2,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TTLL10,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000162592,True,compatible,,True,True,True,,0.343976,0.293976,0.238024,0,80,unavailable,0.2,0.1,0.1,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC27,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000162620,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.306522,0.242857,0.162442,0,6,partial,1.9,1.2,1.6,"kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); parathyroid gland / glandular cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRRIQ3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000162624,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 43.4783% (minimum 75%, Missing); esophagus: 58.8235% (minimum 70%, Missing); salivary gland: 27.7778% (minimum 70%, Missing); tongue: 50.0000% (minimum 70%, Missing); urinary bladder: 66.6667% (minimum 70%, Missing)",0.183333,-0.422222,-0.315217,0,80,unavailable,1.3,2.6,0.2,"basal ganglia: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LHX8,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000162639,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.143417,0.142169,0.0921687,0,2,partial,13.1,13.1,18.2,"thymus: 18.2 nTPM (manageable, limit 5); lymph node: 13.1 nTPM (protected, limit 3); bone marrow: 13.1 nTPM (vital, limit 1); hypothalamus: 12.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); spleen: 10.8 nTPM (manageable, limit 5); basal ganglia: 10.2 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); rectum: 9.2 nTPM (protected, limit 3); amygdala: 7.9 nTPM (vital, limit 1); hippocampal formation: 7.4 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 3); urinary bladder: 6 nTPM (protected, limit 3); tongue: 5.9 nTPM (protected, limit 3); adipose tissue: 5.2 nTPM (manageable, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); duodenum: 4.8 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); lung: 4.6 nTPM (vital, limit 1); cerebellum: 4.2 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); skeletal muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HENMT1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000162641,True,compatible,,True,True,True,,0.29,0.3,0.25,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AKNAD1,current_adaptive,True,False,True,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000162753,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.128788,0,10,partial,0.8,0.1,0.2,,adrenal gland / glandular cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC9C2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000162763,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.10597,0.09375,0,80,unavailable,3,3.9,0,"parathyroid gland: 3.9 nTPM (protected, limit 3); choroid plexus: 3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRRC52,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000162771,True,compatible,,True,True,True,,0.348695,0.3,0.25,0,4,partial,0.4,0.3,0.7,,,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GARIN4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000162779,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.230769,0,3,partial,0.3,0.2,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),51,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AXDND1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000162782,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.345305,0.3,0.152128,0,4,partial,2.3,0.8,0.8,"basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TDRD5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000162814,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.34,0.0983871,0.0357143,0,6,partial,2.7,2.5,0.7,"choroid plexus: 2.7 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA17,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000162843,True,compatible,,True,True,True,,0.35,0.3,0.208333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,WDR64,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000162852,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 49.8008% (minimum 65%, Missing); adrenal gland: 40.0641% (minimum 75%, Missing); amygdala: 67.5676% (minimum 75%, Missing); basal ganglia: 58.4112% (minimum 75%, Missing); bone marrow: 35.0140% (minimum 75%, Missing); cerebellum: 42.5170% (minimum 75%, Missing); cerebral cortex: 44.6429% (minimum 75%, Missing); choroid plexus: 48.8281% (minimum 75%, Missing); colon: 48.4496% (minimum 70%, Missing); duodenum: 55.8036% (minimum 75%, Missing); esophagus: 43.7063% (minimum 70%, Missing); heart muscle: 59.5238% (minimum 75%, Missing); hippocampal formation: 66.4894% (minimum 75%, Missing); hypothalamus: 51.8672% (minimum 75%, Missing); kidney: 60.0962% (minimum 75%, Missing); liver: 35.4108% (minimum 75%, Missing); lung: 56.5611% (minimum 75%, Missing); lymph node: 43.4028% (minimum 70%, Missing); midbrain: 63.4518% (minimum 75%, Missing); pancreas: 55.8036% (minimum 75%, Missing); parathyroid gland: 53.4188% (minimum 70%, Missing); pituitary gland: 63.1313% (minimum 75%, Missing); rectum: 51.8672% (minimum 70%, Missing); retina: 43.5540% (minimum 75%, Missing); salivary gland: 64.1026% (minimum 65%, Approved); skeletal muscle: 28.9352% (minimum 75%, Missing); skin: 55.8036% (minimum 65%, Missing); small intestine: 49.4071% (minimum 75%, Missing); smooth muscle: 56.3063% (minimum 75%, Missing); spinal cord: 71.0227% (minimum 75%, Missing); spleen: 55.0661% (minimum 65%, Missing); stomach: 60.3865% (minimum 70%, Missing); thymus: 47.3485% (minimum 65%, Missing); thyroid gland: 48.0769% (minimum 65%, Missing); tongue: 25.0501% (minimum 70%, Missing); urinary bladder: 53.4188% (minimum 70%, Missing)",-0.176515,-0.449499,-0.460648,0,2,partial,30.7,37.4,13.9,"tongue: 37.4 nTPM (protected, limit 3); skeletal muscle: 30.7 nTPM (vital, limit 1); bone marrow: 23.2 nTPM (vital, limit 1); liver: 22.8 nTPM (vital, limit 1); adrenal gland: 18.7 nTPM (vital, limit 1); cerebellum: 16.9 nTPM (vital, limit 1); lymph node: 16.3 nTPM (protected, limit 3); retina: 16.2 nTPM (vital, limit 1); esophagus: 16.1 nTPM (protected, limit 3); cerebral cortex: 15.5 nTPM (vital, limit 1); thymus: 13.9 nTPM (manageable, limit 5); thyroid gland: 13.5 nTPM (manageable, limit 5); colon: 13.3 nTPM (protected, limit 3); choroid plexus: 13.1 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); adipose tissue: 12.6 nTPM (manageable, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); rectum: 11.6 nTPM (protected, limit 3); parathyroid gland: 10.9 nTPM (protected, limit 3); urinary bladder: 10.9 nTPM (protected, limit 3); spleen: 10.2 nTPM (manageable, limit 5); pancreas: 9.9 nTPM (vital, limit 1); skin: 9.9 nTPM (manageable, limit 5); duodenum: 9.9 nTPM (vital, limit 1); smooth muscle: 9.7 nTPM (vital, limit 1); lung: 9.6 nTPM (vital, limit 1); basal ganglia: 8.9 nTPM (vital, limit 1); heart muscle: 8.5 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); stomach: 8.2 nTPM (protected, limit 3); pituitary gland: 7.3 nTPM (vital, limit 1); midbrain: 7.2 nTPM (vital, limit 1); salivary gland: 7 nTPM (protected, limit 4); hippocampal formation: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); spinal cord: 5.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CNST,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000162928,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.1814% (minimum 65%, Missing); adrenal gland: 65.0224% (minimum 75%, Missing); amygdala: 66.5138% (minimum 75%, Missing); basal ganglia: 67.4419% (minimum 75%, Missing); bone marrow: 66.5138% (minimum 75%, Missing); cerebellum: 70.7317% (minimum 75%, Missing); cerebral cortex: 68.7204% (minimum 75%, Missing); choroid plexus: 65.9091% (minimum 75%, Missing); colon: 59.4262% (minimum 70%, Missing); duodenum: 59.4262% (minimum 75%, Missing); esophagus: 59.4262% (minimum 70%, Missing); heart muscle: 55.7692% (minimum 75%, Missing); hippocampal formation: 68.7204% (minimum 75%, Missing); hypothalamus: 67.4419% (minimum 75%, Missing); kidney: 52.5362% (minimum 75%, Missing); liver: 37.3711% (minimum 75%, Missing); lung: 61.7021% (minimum 75%, Missing); lymph node: 68.7204% (minimum 70%, Missing); midbrain: 67.7570% (minimum 75%, Missing); pancreas: 55.9846% (minimum 75%, Missing); parathyroid gland: 61.1814% (minimum 70%, Missing); pituitary gland: 66.8203% (minimum 75%, Missing); rectum: 58.4677% (minimum 70%, Missing); retina: 63.0435% (minimum 75%, Missing); salivary gland: 63.3188% (minimum 70%, Missing); skeletal muscle: 50.6993% (minimum 75%, Missing); small intestine: 60.4167% (minimum 75%, Missing); smooth muscle: 65.0224% (minimum 75%, Missing); spinal cord: 65.3153% (minimum 75%, Missing); stomach: 59.6708% (minimum 70%, Missing); thyroid gland: 52.1583% (minimum 65%, Missing); tongue: 52.5362% (minimum 70%, Missing); urinary bladder: 52.1583% (minimum 70%, Missing)",-0.128417,-0.178417,-0.376289,0,5,partial,24.3,13.3,13.3,"liver: 24.3 nTPM (vital, limit 1); skeletal muscle: 14.1 nTPM (vital, limit 1); urinary bladder: 13.3 nTPM (protected, limit 3); thyroid gland: 13.3 nTPM (manageable, limit 5); tongue: 13.1 nTPM (protected, limit 3); kidney: 13.1 nTPM (vital, limit 1); heart muscle: 11.5 nTPM (vital, limit 1); pancreas: 11.4 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 3); colon: 9.9 nTPM (protected, limit 3); duodenum: 9.9 nTPM (vital, limit 1); esophagus: 9.9 nTPM (protected, limit 3); stomach: 9.8 nTPM (protected, limit 3); small intestine: 9.5 nTPM (vital, limit 1); parathyroid gland: 9.2 nTPM (protected, limit 3); adipose tissue: 9.2 nTPM (manageable, limit 5); lung: 9 nTPM (vital, limit 1); retina: 8.5 nTPM (vital, limit 1); salivary gland: 8.4 nTPM (protected, limit 3); adrenal gland: 7.8 nTPM (vital, limit 1); smooth muscle: 7.8 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); skin: 7.6 nTPM (manageable, limit 5); choroid plexus: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); thymus: 7.2 nTPM (manageable, limit 5); hypothalamus: 7 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 3); hippocampal formation: 6.6 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); cerebellum: 6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer - neuropil: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: High (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PEX13,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000162931,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 65.0718% (minimum 75%, Missing); cerebellum: 46.9505% (minimum 75%, Missing); cerebral cortex: 72.9875% (minimum 75%, Missing)",0.266242,0.200662,-0.280495,0,5,partial,46.1,4.5,6.3,"cerebellum: 46.1 nTPM (vital, limit 1); basal ganglia: 21.9 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 3); kidney: 2.9 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRIM17,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000162994,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 71.9212% (minimum 75%, Missing); retina: 66.0633% (minimum 75%, Missing)",0.0987179,0.0373737,-0.0893665,0,80,unavailable,7.5,5.2,4.9,"retina: 7.5 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.2 nTPM (protected, limit 3); choroid plexus: 4.2 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CLHC1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000162999,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 72.0000% (minimum 75%, Missing); amygdala: 72.0000% (minimum 75%, Missing); basal ganglia: 64.2857% (minimum 75%, Missing); cerebral cortex: 67.9245% (minimum 75%, Missing); duodenum: 73.4694% (minimum 75%, Missing); heart muscle: 54.5455% (minimum 70%, Approved); hippocampal formation: 67.9245% (minimum 75%, Missing); kidney: 67.9245% (minimum 75%, Missing); skeletal muscle: 69.2308% (minimum 70%, Approved); smooth muscle: 66.6667% (minimum 70%, Approved); stomach: 48.6486% (minimum 70%, Missing); tongue: 69.2308% (minimum 70%, Missing)",0.0792453,-0.213514,-0.154545,0,2,partial,3,3.8,1.7,"stomach: 3.8 nTPM (protected, limit 3); heart muscle: 3 nTPM (vital, limit 2); basal ganglia: 2 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DUSP19,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000163006,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"thymus: 63.0952% (minimum 65%, Missing)",-0.0190476,0.128125,0.00714286,0,2,partial,3.4,4.3,6.2,"thymus: 6.2 nTPM (manageable, limit 5); bone marrow: 3.4 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC138,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000163012,True,compatible,,True,True,True,,0.35,0.3,0.1875,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZSWIM2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000163060,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.206204,0,9,partial,0.6,0,0,,bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEKT4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000163114,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PDHA2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000163206,True,compatible,,True,True,True,,0.35,0.3,0.24945,0,2,partial,1.2,0.1,0.2,,,54,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SMCP,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,False,unchanged,
ENSG00000163239,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.184877,0.235986,0.12399,0,80,unavailable,7.8,3.7,10.7,"adipose tissue: 10.7 nTPM (manageable, limit 5); thyroid gland: 10.7 nTPM (manageable, limit 5); spleen: 8.7 nTPM (manageable, limit 5); lung: 7.8 nTPM (vital, limit 1); heart muscle: 7.4 nTPM (vital, limit 1); liver: 4.4 nTPM (vital, limit 1); adrenal gland: 4.3 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); kidney: 3.4 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TDRD10,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000163254,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.191176,0,0,routine_complete,0.1,0,0,,eye / lens fiber cells: High (Supported),59,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CRYGC,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000163263,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346622,0.286622,0.195513,0,80,unavailable,1.7,0.4,0.1,"choroid plexus: 1.7 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP141,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000163283,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,12,partial,3.8,0,0.1,,colon / enterocytes - Microvilli: Medium (Enhanced); duodenum / enterocytes - Microvilli: High (Enhanced); rectum / enterocytes - Microvilli: High (Enhanced); skin 1 / fibrohistiocytic cells: Low (Enhanced); small intestine / enterocytes - Microvilli: High (Enhanced),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / fibrohistiocytic cells; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ALPP,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000163286,False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"lung: 69.2308% (minimum 70%, Approved)",0.25,0.2,-0.00769231,0,11,partial,0.4,0.1,0.1,,colon / enterocytes - Microvilli: Medium (Approved); duodenum / enterocytes - Microvilli: High (Approved); rectum / enterocytes - Microvilli: High (Approved); skin 1 / fibrohistiocytic cells: Low (Approved); small intestine / enterocytes - Microvilli: High (Approved),92,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin 1 / fibrohistiocytic cells; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ALPG,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000163312,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.5042% (minimum 65%, Missing); adrenal gland: 45.0000% (minimum 75%, Missing); bone marrow: 61.5385% (minimum 75%, Missing); cerebellum: 68.5714% (minimum 75%, Missing); choroid plexus: 56.6929% (minimum 75%, Missing); colon: 65.4545% (minimum 70%, Missing); duodenum: 69.9029% (minimum 75%, Missing); esophagus: 68.5714% (minimum 70%, Missing); heart muscle: 59.5041% (minimum 75%, Missing); kidney: 58.0645% (minimum 75%, Missing); liver: 57.6000% (minimum 75%, Missing); lung: 65.4545% (minimum 75%, Missing); lymph node: 44.1718% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 57.1429% (minimum 65%, Approved); pituitary gland: 62.6087% (minimum 75%, Missing); rectum: 65.4545% (minimum 70%, Missing); retina: 57.6000% (minimum 75%, Missing); salivary gland: 61.5385% (minimum 70%, Missing); skeletal muscle: 51.0638% (minimum 75%, Missing); small intestine: 62.6087% (minimum 75%, Missing); smooth muscle: 63.1579% (minimum 75%, Missing); spleen: 54.1353% (minimum 65%, Missing); stomach: 66.6667% (minimum 70%, Missing); thymus: 48.0000% (minimum 65%, Missing); thyroid gland: 56.2500% (minimum 65%, Missing); tongue: 48.0000% (minimum 70%, Missing); urinary bladder: 63.1579% (minimum 70%, Missing)",-0.17,-0.258282,-0.3,0,3,partial,8.8,9.1,7.8,"lymph node: 9.1 nTPM (protected, limit 3); adrenal gland: 8.8 nTPM (vital, limit 1); tongue: 7.8 nTPM (protected, limit 3); thymus: 7.8 nTPM (manageable, limit 5); skeletal muscle: 6.9 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); thyroid gland: 5.6 nTPM (manageable, limit 5); choroid plexus: 5.5 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 4); retina: 5.3 nTPM (vital, limit 1); liver: 5.3 nTPM (vital, limit 1); kidney: 5.2 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 3); small intestine: 4.3 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 3); rectum: 3.8 nTPM (protected, limit 3); lung: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); pancreas: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 3); esophagus: 3.3 nTPM (protected, limit 3); cerebellum: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HELQ,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000163322,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 73.4266% (minimum 75%, Missing); bone marrow: 58.0110% (minimum 75%, Uncertain); esophagus: 67.7419% (minimum 70%, Uncertain); heart muscle: 74.4681% (minimum 75%, Uncertain); kidney: 72.9167% (minimum 75%, Uncertain); lung: 74.4681% (minimum 75%, Uncertain); lymph node: 57.3770% (minimum 70%, Uncertain); skeletal muscle: 62.8743% (minimum 75%, Uncertain); thyroid gland: 59.3220% (minimum 65%, Uncertain)",-0.0567797,-0.12623,-0.16989,0,3,partial,7.6,7.8,7.2,"lymph node: 7.8 nTPM (protected, limit 3); bone marrow: 7.6 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6.2 nTPM (vital, limit 1); skin: 5.4 nTPM (manageable, limit 5); esophagus: 5 nTPM (protected, limit 3); kidney: 3.9 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); urinary bladder: 3.7 nTPM (protected, limit 3); lung: 3.6 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); duodenum: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); salivary gland: 3.3 nTPM (protected, limit 3); pancreas: 3.3 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); small intestine: 3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ABRAXAS1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000163357,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 72.2222% (minimum 75%, Missing)",0.0342105,0.255882,-0.0277778,0,80,unavailable,2.5,0.3,3,"retina: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DCST1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000163376,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 35.6808% (minimum 75%, Missing); heart muscle: 67.2566% (minimum 75%, Missing); lymph node: 27.6364% (minimum 70%, Missing); small intestine: 73.7864% (minimum 75%, Missing); spleen: 57.5758% (minimum 65%, Missing)",-0.0742424,-0.423636,-0.393192,0,0,routine_complete,13.7,19.9,5.6,"lymph node: 19.9 nTPM (protected, limit 3); bone marrow: 13.7 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); heart muscle: 3.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KBTBD8,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000163421,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 14.8396% (minimum 70%, Approved); lung: 46.6387% (minimum 70%, Approved); spleen: 33.6364% (minimum 60%, Approved)",-0.263636,0.00680473,-0.551604,0,3,partial,63.7,5.8,21.9,"bone marrow: 63.7 nTPM (vital, limit 2); spleen: 21.9 nTPM (manageable, limit 10); lung: 12.7 nTPM (vital, limit 2); urinary bladder: 5.8 nTPM (protected, limit 4); tongue: 4.1 nTPM (protected, limit 3); liver: 2.4 nTPM (vital, limit 2); pancreas: 1.1 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PROK2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000163424,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0,0,,bronchus / respiratory epithelial cells: Low (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX55,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000163440,True,compatible,,True,True,True,,0.35,0.3,0.248423,0,1,partial,0.1,0.3,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PDCL2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000163467,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348889,0.298889,0.247559,0,80,unavailable,2.2,1,1,"retina: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TSACC,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000163491,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335632,0.00867769,0.034897,0,80,unavailable,9.4,14.1,0.5,"tongue: 14.1 nTPM (protected, limit 3); skeletal muscle: 9.4 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); pituitary gland: 3.3 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NEK10,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000163507,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 38.0952% (minimum 75%, Missing); cerebellum: 75.0000% (minimum 75%, Missing); cerebral cortex: 68.5714% (minimum 75%, Missing); colon: 68.5714% (minimum 70%, Missing); duodenum: 70.5882% (minimum 75%, Missing); esophagus: 68.5714% (minimum 70%, Missing); lung: 72.7273% (minimum 75%, Missing); lymph node: 39.3443% (minimum 70%, Missing); rectum: 60.0000% (minimum 70%, Missing); retina: 63.1579% (minimum 75%, Missing); small intestine: 68.5714% (minimum 75%, Missing); smooth muscle: 72.7273% (minimum 75%, Missing); thymus: 42.8571% (minimum 65%, Missing)",-0.221429,-0.306557,-0.369048,0,4,partial,3.9,3.7,3.2,"bone marrow: 3.9 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 3); retina: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CIP2A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000163512,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 38.0048% (minimum 65%, Missing); adrenal gland: 58.6081% (minimum 75%, Missing); amygdala: 53.3333% (minimum 75%, Missing); basal ganglia: 52.6316% (minimum 75%, Missing); bone marrow: 43.7158% (minimum 75%, Missing); cerebellum: 60.8365% (minimum 75%, Missing); cerebral cortex: 48.3384% (minimum 75%, Missing); choroid plexus: 52.8053% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); duodenum: 57.9710% (minimum 75%, Missing); esophagus: 63.2411% (minimum 70%, Missing); heart muscle: 52.9801% (minimum 75%, Missing); hippocampal formation: 54.7945% (minimum 75%, Missing); hypothalamus: 51.2821% (minimum 75%, Missing); kidney: 52.6316% (minimum 75%, Missing); liver: 59.4796% (minimum 75%, Missing); lung: 56.9395% (minimum 75%, Missing); lymph node: 62.5000% (minimum 70%, Missing); midbrain: 53.6913% (minimum 75%, Missing); pancreas: 59.7015% (minimum 75%, Missing); parathyroid gland: 56.3380% (minimum 70%, Missing); pituitary gland: 54.2373% (minimum 75%, Missing); rectum: 62.7451% (minimum 70%, Missing); retina: 54.7945% (minimum 75%, Missing); salivary gland: 48.0480% (minimum 70%, Missing); skeletal muscle: 54.0541% (minimum 75%, Missing); skin: 62.5000% (minimum 65%, Missing); small intestine: 59.4796% (minimum 75%, Missing); smooth muscle: 58.3942% (minimum 75%, Missing); spinal cord: 62.0155% (minimum 75%, Missing); spleen: 62.0155% (minimum 65%, Missing); stomach: 59.9251% (minimum 70%, Missing); thymus: 53.8721% (minimum 65%, Missing); thyroid gland: 54.0541% (minimum 65%, Missing); tongue: 58.1818% (minimum 70%, Missing); urinary bladder: 58.8235% (minimum 70%, Missing)",-0.269952,-0.21952,-0.312842,0,2,partial,20.6,17.3,26.1,"adipose tissue: 26.1 nTPM (manageable, limit 5); bone marrow: 20.6 nTPM (vital, limit 1); salivary gland: 17.3 nTPM (protected, limit 3); cerebral cortex: 17.1 nTPM (vital, limit 1); hypothalamus: 15.2 nTPM (vital, limit 1); basal ganglia: 14.4 nTPM (vital, limit 1); kidney: 14.4 nTPM (vital, limit 1); choroid plexus: 14.3 nTPM (vital, limit 1); heart muscle: 14.2 nTPM (vital, limit 1); amygdala: 14 nTPM (vital, limit 1); midbrain: 13.8 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); thyroid gland: 13.6 nTPM (manageable, limit 5); skeletal muscle: 13.6 nTPM (vital, limit 1); pituitary gland: 13.5 nTPM (vital, limit 1); retina: 13.2 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.4 nTPM (protected, limit 3); lung: 12.1 nTPM (vital, limit 1); duodenum: 11.6 nTPM (vital, limit 1); tongue: 11.5 nTPM (protected, limit 3); smooth muscle: 11.4 nTPM (vital, limit 1); adrenal gland: 11.3 nTPM (vital, limit 1); urinary bladder: 11.2 nTPM (protected, limit 3); small intestine: 10.9 nTPM (vital, limit 1); liver: 10.9 nTPM (vital, limit 1); pancreas: 10.8 nTPM (vital, limit 1); stomach: 10.7 nTPM (protected, limit 3); cerebellum: 10.3 nTPM (vital, limit 1); colon: 10 nTPM (protected, limit 3); spinal cord: 9.8 nTPM (vital, limit 1); spleen: 9.8 nTPM (manageable, limit 5); skin: 9.6 nTPM (manageable, limit 5); lymph node: 9.6 nTPM (protected, limit 3); rectum: 9.5 nTPM (protected, limit 3); esophagus: 9.3 nTPM (protected, limit 3)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AZI2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000163527,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 61.3440% (minimum 75%, Missing); bone marrow: 59.4455% (minimum 75%, Missing); colon: 61.5077% (minimum 70%, Missing); duodenum: 66.4265% (minimum 75%, Missing); esophagus: 68.0443% (minimum 70%, Missing); heart muscle: 65.9042% (minimum 75%, Missing); kidney: 65.8101% (minimum 75%, Missing); liver: 55.9466% (minimum 75%, Missing); lung: 65.9042% (minimum 75%, Missing); lymph node: 61.1812% (minimum 70%, Missing); pancreas: 67.4963% (minimum 75%, Missing); parathyroid gland: 55.4420% (minimum 70%, Missing); rectum: 60.7779% (minimum 70%, Missing); retina: 71.1420% (minimum 75%, Missing); salivary gland: 65.5295% (minimum 70%, Missing); skeletal muscle: 60.6180% (minimum 75%, Missing); small intestine: 65.8571% (minimum 75%, Missing); smooth muscle: 62.3816% (minimum 75%, Missing); stomach: 63.1940% (minimum 70%, Missing); thymus: 56.8785% (minimum 65%, Missing); thyroid gland: 54.0445% (minimum 65%, Missing); tongue: 62.3816% (minimum 70%, Missing); urinary bladder: 62.8065% (minimum 70%, Missing)",-0.109555,-0.14558,-0.190534,0,4,partial,72.6,74.1,78.4,"thyroid gland: 78.4 nTPM (manageable, limit 5); parathyroid gland: 74.1 nTPM (protected, limit 3); liver: 72.6 nTPM (vital, limit 1); thymus: 69.9 nTPM (manageable, limit 5); bone marrow: 62.9 nTPM (vital, limit 1); skeletal muscle: 59.9 nTPM (vital, limit 1); rectum: 59.5 nTPM (protected, limit 3); lymph node: 58.5 nTPM (protected, limit 3); adrenal gland: 58.1 nTPM (vital, limit 1); colon: 57.7 nTPM (protected, limit 3); smooth muscle: 55.6 nTPM (vital, limit 1); tongue: 55.6 nTPM (protected, limit 3); urinary bladder: 54.6 nTPM (protected, limit 3); stomach: 53.7 nTPM (protected, limit 3); salivary gland: 48.5 nTPM (protected, limit 3); kidney: 47.9 nTPM (vital, limit 1); small intestine: 47.8 nTPM (vital, limit 1); heart muscle: 47.7 nTPM (vital, limit 1); lung: 47.7 nTPM (vital, limit 1); duodenum: 46.6 nTPM (vital, limit 1); pancreas: 44.4 nTPM (vital, limit 1); skin: 43.6 nTPM (manageable, limit 5); esophagus: 43.3 nTPM (protected, limit 3); spleen: 43.1 nTPM (manageable, limit 10); adipose tissue: 41.3 nTPM (manageable, limit 5); retina: 37.4 nTPM (vital, limit 1); cerebral cortex: 26.8 nTPM (vital, limit 1); spinal cord: 25.6 nTPM (vital, limit 1); pituitary gland: 24.2 nTPM (vital, limit 1); choroid plexus: 22.1 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); basal ganglia: 20.3 nTPM (vital, limit 1); amygdala: 19.5 nTPM (vital, limit 1); hypothalamus: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.9 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,STT3B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000163530,True,compatible,,True,True,True,,0.319697,0.3,0.219697,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DPPA2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,True,True,True,True,gained,selectivity_revised
ENSG00000163535,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.0354664,0.10203,0.176686,0,12,partial,6.7,7.8,14.5,"thymus: 14.5 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 3); bone marrow: 6.7 nTPM (vital, limit 6); rectum: 3.1 nTPM (protected, limit 3); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1)",bronchus / basal cells: Low (Enhanced); colon / enterocytes: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / endocrine cells: Medium (Enhanced); duodenum / goblet cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / enterocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / enterocytes: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),84,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SGO2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000163554,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 2.0970% (minimum 75%, Missing)",0.0925926,0.3,-0.72903,0,1,partial,74.7,0,1.1,"bone marrow: 74.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin 1 / melanocytes; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPTA1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000163645,True,compatible,,True,True,True,,0.35,0.296552,0.243127,0,4,partial,0.6,0.6,1.3,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ERICH6,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000163646,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 5.8824% (minimum 75%, Missing); duodenum: 18.7500% (minimum 75%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 2.3622% (minimum 75%, Missing); small intestine: 60.0000% (minimum 75%, Missing); spinal cord: 60.0000% (minimum 75%, Missing)",0.1,0.3,-0.726378,0,80,unavailable,12.4,0,0.1,"retina: 12.4 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CLRN1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000163684,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 51.4563% (minimum 65%, Missing); adrenal gland: 49.0741% (minimum 75%, Missing); amygdala: 56.9892% (minimum 75%, Missing); basal ganglia: 51.4563% (minimum 75%, Missing); bone marrow: 53.0000% (minimum 75%, Missing); cerebellum: 45.2991% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); choroid plexus: 60.2273% (minimum 75%, Missing); colon: 44.5378% (minimum 70%, Missing); duodenum: 44.5378% (minimum 75%, Missing); esophagus: 48.1818% (minimum 70%, Missing); heart muscle: 33.5443% (minimum 75%, Missing); hippocampal formation: 57.6087% (minimum 75%, Missing); hypothalamus: 56.3830% (minimum 75%, Missing); kidney: 37.8571% (minimum 75%, Missing); liver: 32.1212% (minimum 75%, Missing); lung: 57.6087% (minimum 75%, Missing); lymph node: 57.6087% (minimum 70%, Missing); midbrain: 59.5506% (minimum 75%, Missing); pancreas: 47.3214% (minimum 75%, Missing); parathyroid gland: 41.7323% (minimum 70%, Missing); pituitary gland: 48.1818% (minimum 75%, Missing); rectum: 46.0870% (minimum 70%, Missing); retina: 51.9608% (minimum 75%, Missing); salivary gland: 52.4752% (minimum 70%, Missing); skeletal muscle: 11.9101% (minimum 75%, Missing); skin: 50.9615% (minimum 65%, Missing); small intestine: 44.1667% (minimum 75%, Missing); smooth muscle: 43.4426% (minimum 75%, Missing); spinal cord: 61.6279% (minimum 75%, Missing); spleen: 48.6239% (minimum 65%, Missing); stomach: 50.4762% (minimum 70%, Missing); thymus: 45.6897% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); tongue: 12.3832% (minimum 70%, Missing); urinary bladder: 51.4563% (minimum 70%, Missing)",-0.193103,-0.576168,-0.630899,0,80,unavailable,39.2,37.5,6.3,"skeletal muscle: 39.2 nTPM (vital, limit 1); tongue: 37.5 nTPM (protected, limit 3); liver: 11.2 nTPM (vital, limit 1); heart muscle: 10.5 nTPM (vital, limit 1); kidney: 8.7 nTPM (vital, limit 1); parathyroid gland: 7.4 nTPM (protected, limit 3); smooth muscle: 6.9 nTPM (vital, limit 1); small intestine: 6.7 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); colon: 6.6 nTPM (protected, limit 3); cerebellum: 6.4 nTPM (vital, limit 1); thymus: 6.3 nTPM (manageable, limit 5); rectum: 6.2 nTPM (protected, limit 3); pancreas: 5.9 nTPM (vital, limit 1); esophagus: 5.7 nTPM (protected, limit 3); pituitary gland: 5.7 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); adrenal gland: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.3 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); stomach: 5.2 nTPM (protected, limit 3); skin: 5.1 nTPM (manageable, limit 5); urinary bladder: 5 nTPM (protected, limit 3); basal ganglia: 5 nTPM (vital, limit 1); retina: 4.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 3); bone marrow: 4.7 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 3); lung: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.9 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RPP14,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000163689,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.327477,0.0380952,0.173404,0,80,unavailable,1.8,7.7,0.5,"esophagus: 7.7 nTPM (protected, limit 3); pituitary gland: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP20DC,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000163705,True,compatible,,True,True,True,,0.343367,0.298333,0.23358,0,80,unavailable,1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FANCD2OS,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000163746,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.320588,0.277778,0.173077,0,80,unavailable,1.1,0.3,0.4,"bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PLSCR2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000163749,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.312428,0.285207,0.204155,0,80,unavailable,1.6,0.5,1.3,"liver: 1.6 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC158,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000163793,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.241323,0,2,partial,2.2,0.1,0.1,"cerebral cortex: 2.2 nTPM (vital, limit 2)",,53,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAJC5G,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000163806,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.208084,0,1,partial,2.3,0.9,1.8,"pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPDYA,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000163808,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 58.1967% (minimum 75%, Missing); thymus: 44.0994% (minimum 65%, Missing)",-0.209006,0.0634409,-0.168033,0,5,partial,5.1,2.2,9,"thymus: 9 nTPM (manageable, limit 5); bone marrow: 5.1 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thymus / cortical cells: High (Approved); thymus / medullary cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; thymus / cortical cells; thymus / medullary cells; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KIF15,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000163867,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.5850% (minimum 65%, Missing); adrenal gland: 55.7576% (minimum 75%, Missing); bone marrow: 37.5510% (minimum 75%, Missing); cerebellum: 62.1622% (minimum 75%, Missing); cerebral cortex: 64.3357% (minimum 75%, Missing); colon: 60.5263% (minimum 70%, Missing); duodenum: 59.7403% (minimum 75%, Missing); esophagus: 57.8616% (minimum 70%, Missing); heart muscle: 58.5987% (minimum 75%, Missing); kidney: 58.5987% (minimum 75%, Missing); liver: 67.1533% (minimum 75%, Missing); lung: 59.7403% (minimum 75%, Missing); lymph node: 49.7297% (minimum 70%, Missing); pancreas: 65.7143% (minimum 75%, Missing); parathyroid gland: 55.7576% (minimum 70%, Missing); pituitary gland: 57.8616% (minimum 75%, Missing); rectum: 56.0976% (minimum 70%, Missing); retina: 50.5495% (minimum 75%, Missing); salivary gland: 64.7887% (minimum 70%, Missing); skeletal muscle: 73.0159% (minimum 75%, Missing); skin: 53.4884% (minimum 65%, Missing); small intestine: 57.1429% (minimum 75%, Missing); smooth muscle: 59.3548% (minimum 75%, Missing); spinal cord: 74.1935% (minimum 75%, Missing); spleen: 47.1795% (minimum 65%, Missing); stomach: 56.7901% (minimum 70%, Missing); thymus: 53.8012% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); tongue: 67.1533% (minimum 70%, Missing); urinary bladder: 63.4483% (minimum 70%, Missing)",-0.178205,-0.202703,-0.37449,0,2,partial,15.3,9.3,10.3,"bone marrow: 15.3 nTPM (vital, limit 1); spleen: 10.3 nTPM (manageable, limit 5); lymph node: 9.3 nTPM (protected, limit 3); thyroid gland: 9.2 nTPM (manageable, limit 5); retina: 9 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); thymus: 7.9 nTPM (manageable, limit 5); parathyroid gland: 7.3 nTPM (protected, limit 3); adrenal gland: 7.3 nTPM (vital, limit 1); rectum: 7.2 nTPM (protected, limit 3); stomach: 7 nTPM (protected, limit 3); small intestine: 6.9 nTPM (vital, limit 1); pituitary gland: 6.7 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 3); heart muscle: 6.5 nTPM (vital, limit 1); kidney: 6.5 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); colon: 6 nTPM (protected, limit 3); cerebellum: 5.6 nTPM (vital, limit 1); adipose tissue: 5.5 nTPM (manageable, limit 5); urinary bladder: 5.3 nTPM (protected, limit 3); cerebral cortex: 5.1 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 3); pancreas: 4.8 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 3); skeletal muscle: 3.4 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZMYM6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000163879,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 40.6009% (minimum 75%, Missing)",0.336508,0.194737,-0.343991,0,10,partial,77.1,8.8,10.3,"choroid plexus: 77.1 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); kidney: 11.8 nTPM (vital, limit 6); liver: 11.7 nTPM (vital, limit 6); retina: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); hippocampal formation: 11.3 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 6); pancreas: 8.9 nTPM (vital, limit 6); cerebral cortex: 7.5 nTPM (vital, limit 6); stomach: 6.2 nTPM (protected, limit 3); colon: 5.1 nTPM (protected, limit 3); salivary gland: 4.4 nTPM (protected, limit 3); small intestine: 2.2 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / enterocytes - Gradient: Ascending (Enhanced); rectum / enterocytes: Low (Enhanced); rectum / enterocytes - Gradient: Ascending (Enhanced); salivary gland / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),79,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Gradient; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNALI1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000163885,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 70.7865% (minimum 75%, Missing)",0.35,0.3,-0.0421348,0,4,partial,13,0.1,0.1,"choroid plexus: 13 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP100,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000163923,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.277083,0.244188,0.195933,0,4,partial,19.8,12.9,16.1,"pancreas: 19.8 nTPM (vital, limit 2); bone marrow: 19.1 nTPM (vital, limit 2); thymus: 16.1 nTPM (manageable, limit 5); lymph node: 12.9 nTPM (protected, limit 4); colon: 12.1 nTPM (protected, limit 3); amygdala: 11.7 nTPM (vital, limit 1); skin: 11.6 nTPM (manageable, limit 10); basal ganglia: 11.2 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 2); hippocampal formation: 9.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); spinal cord: 8.9 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 4); urinary bladder: 8.2 nTPM (protected, limit 4); salivary gland: 8.1 nTPM (protected, limit 3); smooth muscle: 7.9 nTPM (vital, limit 2); retina: 7.3 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); stomach: 6.6 nTPM (protected, limit 4); small intestine: 6 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 4); lung: 5.3 nTPM (vital, limit 2); pituitary gland: 4.6 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 3); liver: 4.4 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 2); duodenum: 3.3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 2); skeletal muscle: 2.1 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RPL39L,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000163958,True,compatible,,True,True,True,,0.32012,0.3,0.233838,0,80,unavailable,0.8,0,1.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZDHHC19,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000164023,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.8039% (minimum 65%, Missing); bone marrow: 73.0539% (minimum 75%, Missing); choroid plexus: 43.8849% (minimum 75%, Missing); colon: 50.6224% (minimum 70%, Missing); duodenum: 39.2283% (minimum 75%, Missing); esophagus: 43.5714% (minimum 60%, Supported); heart muscle: 58.0952% (minimum 75%, Missing); kidney: 46.7433% (minimum 75%, Missing); liver: 38.3648% (minimum 75%, Missing); lung: 31.4433% (minimum 75%, Missing); pancreas: 51.9149% (minimum 75%, Missing); pituitary gland: 73.0539% (minimum 75%, Missing); rectum: 54.4643% (minimum 70%, Missing); salivary gland: 57.5472% (minimum 70%, Missing); small intestine: 43.8849% (minimum 75%, Missing); smooth muscle: 30.5764% (minimum 75%, Missing); stomach: 47.6562% (minimum 70%, Missing); thyroid gland: 41.0774% (minimum 65%, Missing); urinary bladder: 47.6562% (minimum 70%, Missing)",-0.239226,-0.223438,-0.444236,0,16,partial,27.7,15.8,17.5,"smooth muscle: 27.7 nTPM (vital, limit 1); lung: 26.6 nTPM (vital, limit 1); liver: 19.6 nTPM (vital, limit 1); duodenum: 18.9 nTPM (vital, limit 1); thyroid gland: 17.5 nTPM (manageable, limit 5); esophagus: 15.8 nTPM (protected, limit 6); small intestine: 15.6 nTPM (vital, limit 1); choroid plexus: 15.6 nTPM (vital, limit 1); kidney: 13.9 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 3); urinary bladder: 13.4 nTPM (protected, limit 3); colon: 11.9 nTPM (protected, limit 3); pancreas: 11.3 nTPM (vital, limit 1); rectum: 10.2 nTPM (protected, limit 3); salivary gland: 9 nTPM (protected, limit 3); heart muscle: 8.8 nTPM (vital, limit 1); adipose tissue: 8.2 nTPM (manageable, limit 5); pituitary gland: 4.5 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); parathyroid gland: 3.5 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); tongue: 3.3 nTPM (protected, limit 3); cerebral cortex: 3.2 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); bronchus / ciliated cells (cilia axoneme): Low (Supported); bronchus / ciliated cells (tip of cilia): Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endocrine cells: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / enterocytes: High (Supported); colon / enterocytes - Microvilli: Medium (Supported); colon / fibroblasts: Medium (Supported); colon / goblet cells: Medium (Supported); colon / mucosal lymphoid cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / endocrine cells: Medium (Supported); duodenum / enterocytes: High (Supported); duodenum / enterocytes - Microvilli: High (Supported); duodenum / goblet cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells type I: Medium (Supported); lung / endothelial cells: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / basal cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); nasopharynx / ciliated cells (cilia axoneme): Low (Supported); nasopharynx / ciliated cells (ciliary rootlets): High (Supported); nasopharynx / ciliated cells (tip of cilia): Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / endothelial cells: High (Supported); rectum / enterocytes: High (Supported); rectum / enterocytes - Microvilli: High (Supported); rectum / fibroblasts: Medium (Supported); rectum / goblet cells: High (Supported); rectum / peripheral nerve/ganglion: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / enterocytes - Microvilli: Medium (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / fibroblasts: Low (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),82,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / enterocytes - Microvilli; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SGMS2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000164037,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.306098,0.277556,0.208435,0,80,unavailable,1.7,0.9,1.8,"retina: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC9B1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000164045,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 46.0714% (minimum 75%, Missing); thymus: 60.0000% (minimum 65%, Missing)",-0.05,0.05,-0.289286,0,80,unavailable,15.1,4.3,8.6,"bone marrow: 15.1 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 3); rectum: 3.8 nTPM (protected, limit 3); colon: 3.4 nTPM (protected, limit 3); duodenum: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CDC25A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000164070,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.314384,0.268807,0.0518223,0,5,partial,26.1,13.3,8.2,"retina: 26.1 nTPM (vital, limit 1); esophagus: 13.3 nTPM (protected, limit 12); kidney: 12.9 nTPM (vital, limit 6); adrenal gland: 10.9 nTPM (vital, limit 6); hypothalamus: 9.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); cerebral cortex: 8.2 nTPM (vital, limit 6); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.8 nTPM (vital, limit 1); liver: 7.2 nTPM (vital, limit 6); heart muscle: 6.2 nTPM (vital, limit 6); midbrain: 6.1 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 3); spinal cord: 3.1 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1)",cerebellum / Purkinje cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); lung / macrophages: Low (Enhanced),72,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HSPA4L,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000164113,True,compatible,,True,True,True,,0.348273,0.3,0.25,0,80,unavailable,0,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ADAD1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000164123,True,compatible,,True,True,True,,0.340385,0.3,0.203704,0,80,unavailable,0.5,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPMIP2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000164175,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 71.4286% (minimum 75%, Missing); liver: 45.4545% (minimum 75%, Missing); retina: 71.4286% (minimum 75%, Missing); skin: 50.0000% (minimum 65%, Missing)",-0.15,0.133333,-0.295455,0,80,unavailable,1.2,0.2,1,"liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC45A2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000164220,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 52.1127% (minimum 70%, Missing); duodenum: 69.8113% (minimum 75%, Missing); heart muscle: 68.5185% (minimum 75%, Missing); hypothalamus: 68.5185% (minimum 75%, Missing); liver: 66.0714% (minimum 75%, Missing); midbrain: 58.7302% (minimum 75%, Missing); rectum: 69.8113% (minimum 70%, Missing); retina: 43.5294% (minimum 75%, Missing); salivary gland: 50.6849% (minimum 70%, Missing); skin: 62.7119% (minimum 65%, Missing); small intestine: 62.7119% (minimum 75%, Missing); smooth muscle: 50.6849% (minimum 75%, Missing)",-0.0228814,-0.193151,-0.314706,0,80,unavailable,4.8,3.6,2.2,"retina: 4.8 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); smooth muscle: 3.6 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); midbrain: 2.6 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,F2RL2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000164241,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 71.8563% (minimum 75%, Missing); colon: 64.1711% (minimum 70%, Missing); duodenum: 68.5714% (minimum 75%, Missing); esophagus: 68.9655% (minimum 70%, Missing); heart muscle: 64.8649% (minimum 75%, Missing); kidney: 67.0391% (minimum 75%, Missing); liver: 70.1754% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); pancreas: 70.1754% (minimum 75%, Missing); parathyroid gland: 67.4157% (minimum 70%, Missing); pituitary gland: 64.1711% (minimum 75%, Missing); rectum: 51.0638% (minimum 70%, Missing); retina: 48.5830% (minimum 75%, Missing); skeletal muscle: 71.0059% (minimum 75%, Missing); small intestine: 66.2983% (minimum 75%, Missing); stomach: 61.8557% (minimum 70%, Missing); thyroid gland: 58.2524% (minimum 65%, Missing)",-0.0674757,-0.189362,-0.26417,0,80,unavailable,12.7,11.5,8.6,"retina: 12.7 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 3); thyroid gland: 8.6 nTPM (manageable, limit 5); lymph node: 8 nTPM (protected, limit 3); stomach: 7.4 nTPM (protected, limit 3); colon: 6.7 nTPM (protected, limit 3); pituitary gland: 6.7 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); small intestine: 6.1 nTPM (vital, limit 1); kidney: 5.9 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 3); duodenum: 5.5 nTPM (vital, limit 1); esophagus: 5.4 nTPM (protected, limit 3); thymus: 5.2 nTPM (manageable, limit 5); liver: 5.1 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); tongue: 4.6 nTPM (protected, limit 3); salivary gland: 4.4 nTPM (protected, limit 3); urinary bladder: 3.9 nTPM (protected, limit 3); lung: 3.7 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); smooth muscle: 3 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C5orf63,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000164256,True,compatible,,True,True,True,,0.30122,0.3,0.225,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRDM9,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000164287,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 69.4444% (minimum 75%, Missing)",0.35,0.3,-0.0555556,0,80,unavailable,1.1,0,0,"kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CDC20B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000164299,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPZ1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000164304,True,compatible,,True,True,True,,0.35,0.3,0.210784,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CAGE1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000164334,True,compatible,,True,True,True,,0.35,0.3,0.235816,0,4,partial,0.2,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM170A,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000164399,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 25.0000% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.5,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,IL3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000164404,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.275532,0.235484,0.0946602,0,1,partial,1.6,1,1,"basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GDF9,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000164414,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 60.4770% (minimum 75%, Missing); amygdala: 67.1078% (minimum 75%, Missing); basal ganglia: 65.2574% (minimum 75%, Missing); cerebellum: 53.5445% (minimum 75%, Missing); cerebral cortex: 62.3902% (minimum 75%, Missing); choroid plexus: 50.4979% (minimum 75%, Missing); colon: 48.1030% (minimum 70%, Missing); duodenum: 66.1080% (minimum 75%, Missing); heart muscle: 69.6078% (minimum 75%, Missing); hippocampal formation: 63.9640% (minimum 75%, Missing); hypothalamus: 66.2313% (minimum 75%, Missing); kidney: 63.5063% (minimum 75%, Missing); liver: 52.7489% (minimum 75%, Missing); lung: 49.3741% (minimum 75%, Missing); lymph node: 66.9811% (minimum 70%, Missing); midbrain: 70.8583% (minimum 75%, Missing); pancreas: 69.8819% (minimum 75%, Missing); parathyroid gland: 60.7877% (minimum 70%, Missing); pituitary gland: 65.8627% (minimum 75%, Missing); rectum: 43.5049% (minimum 70%, Missing); retina: 71.7172% (minimum 75%, Missing); salivary gland: 53.6254% (minimum 70%, Missing); skeletal muscle: 72.7459% (minimum 75%, Missing); skin: 59.4640% (minimum 65%, Missing); small intestine: 62.9433% (minimum 75%, Missing); smooth muscle: 62.5000% (minimum 75%, Missing); spinal cord: 69.7446% (minimum 75%, Missing); stomach: 55.4688% (minimum 70%, Missing); urinary bladder: 63.0551% (minimum 70%, Missing)",-0.0553601,-0.264951,-0.256259,0,80,unavailable,36.4,46.1,24.2,"rectum: 46.1 nTPM (protected, limit 3); colon: 38.3 nTPM (protected, limit 3); lung: 36.4 nTPM (vital, limit 1); choroid plexus: 34.8 nTPM (vital, limit 1); liver: 31.8 nTPM (vital, limit 1); cerebellum: 30.8 nTPM (vital, limit 1); salivary gland: 30.7 nTPM (protected, limit 3); stomach: 28.5 nTPM (protected, limit 3); skin: 24.2 nTPM (manageable, limit 5); adrenal gland: 23.2 nTPM (vital, limit 1); parathyroid gland: 22.9 nTPM (protected, limit 3); cerebral cortex: 21.4 nTPM (vital, limit 1); smooth muscle: 21.3 nTPM (vital, limit 1); small intestine: 20.9 nTPM (vital, limit 1); urinary bladder: 20.8 nTPM (protected, limit 3); kidney: 20.4 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); basal ganglia: 18.9 nTPM (vital, limit 1); spleen: 18.5 nTPM (manageable, limit 5); pituitary gland: 18.4 nTPM (vital, limit 1); duodenum: 18.2 nTPM (vital, limit 1); hypothalamus: 18.1 nTPM (vital, limit 1); lymph node: 17.5 nTPM (protected, limit 3); amygdala: 17.4 nTPM (vital, limit 1); thyroid gland: 16.4 nTPM (manageable, limit 5); thymus: 15.8 nTPM (manageable, limit 5); adipose tissue: 15.8 nTPM (manageable, limit 5); heart muscle: 15.5 nTPM (vital, limit 1); spinal cord: 15.4 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); tongue: 15 nTPM (protected, limit 3); midbrain: 14.6 nTPM (vital, limit 1); retina: 14 nTPM (vital, limit 1); esophagus: 13.5 nTPM (protected, limit 3); skeletal muscle: 13.3 nTPM (vital, limit 1); bone marrow: 11.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC35A1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000164451,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.202273,0.286842,0.125486,0,80,unavailable,3.2,0.3,3.9,"choroid plexus: 3.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CALHM4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000164483,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.6250% (minimum 75%, Missing); bone marrow: 50.0000% (minimum 75%, Missing); hippocampal formation: 63.6364% (minimum 75%, Missing); hypothalamus: 72.4138% (minimum 75%, Missing); liver: 71.1864% (minimum 75%, Missing); lung: 56.7568% (minimum 75%, Missing); lymph node: 29.3706% (minimum 70%, Missing); pituitary gland: 47.1910% (minimum 75%, Missing); rectum: 65.6250% (minimum 70%, Missing); smooth muscle: 71.1864% (minimum 75%, Missing); spleen: 31.8182% (minimum 65%, Missing); thymus: 40.7767% (minimum 65%, Missing)",-0.331818,-0.406294,-0.27809,0,80,unavailable,4.7,10.1,9,"lymph node: 10.1 nTPM (protected, limit 3); spleen: 9 nTPM (manageable, limit 5); thymus: 6.1 nTPM (manageable, limit 5); pituitary gland: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SAMD3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000164500,True,compatible,,True,True,True,,0.35,0.276744,0.183333,0,80,unavailable,0.3,0.1,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPMIP7,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000164506,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 55.0633% (minimum 75%, Missing); amygdala: 73.7288% (minimum 75%, Missing); basal ganglia: 73.7288% (minimum 75%, Missing); bone marrow: 66.4122% (minimum 75%, Missing); cerebellum: 48.8764% (minimum 75%, Missing); cerebral cortex: 47.5410% (minimum 75%, Missing); colon: 57.2368% (minimum 70%, Missing); duodenum: 70.1613% (minimum 75%, Missing); esophagus: 50.5814% (minimum 70%, Missing); hippocampal formation: 70.7317% (minimum 75%, Missing); hypothalamus: 67.4419% (minimum 75%, Missing); lung: 71.3115% (minimum 75%, Missing); midbrain: 74.3590% (minimum 75%, Missing); pancreas: 50.5814% (minimum 75%, Missing); parathyroid gland: 19.1209% (minimum 70%, Missing); pituitary gland: 57.2368% (minimum 75%, Missing); rectum: 63.5036% (minimum 70%, Missing); retina: 63.0435% (minimum 75%, Missing); salivary gland: 64.4444% (minimum 70%, Missing); skeletal muscle: 55.0633% (minimum 60%, Enhanced); skin: 47.5410% (minimum 65%, Missing); small intestine: 53.0488% (minimum 75%, Missing); tongue: 68.5039% (minimum 70%, Missing); urinary bladder: 67.4419% (minimum 70%, Missing)",-0.17459,-0.508791,-0.27459,0,9,partial,9.6,36.8,9.6,"parathyroid gland: 36.8 nTPM (protected, limit 3); cerebral cortex: 9.6 nTPM (vital, limit 1); skin: 9.6 nTPM (manageable, limit 5); cerebellum: 9.1 nTPM (vital, limit 1); pancreas: 8.5 nTPM (vital, limit 1); esophagus: 8.5 nTPM (protected, limit 3); small intestine: 7.7 nTPM (vital, limit 1); adrenal gland: 7.1 nTPM (vital, limit 1); skeletal muscle: 7.1 nTPM (vital, limit 6); colon: 6.5 nTPM (protected, limit 3); pituitary gland: 6.5 nTPM (vital, limit 1); retina: 5.1 nTPM (vital, limit 1); rectum: 5 nTPM (protected, limit 3); salivary gland: 4.8 nTPM (protected, limit 3); bone marrow: 4.4 nTPM (vital, limit 1); urinary bladder: 4.2 nTPM (protected, limit 3); hypothalamus: 4.2 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 3); duodenum: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.6 nTPM (vital, limit 1); lung: 3.5 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 3); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lung / alveolar cells type I: Low (Enhanced); lung / alveolar cells type II: Low (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,STXBP5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000164508,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,,0.35,0.3,0.198276,0,2,partial,0.3,0,0,,adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: Medium (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: Medium (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / chondrocytes: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: Medium (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,H2AC1,current_adaptive,False,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000164512,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 71.6418% (minimum 75%, Missing)",0.105906,0.0328244,-0.0335821,0,2,partial,3.8,3.5,3.1,"hypothalamus: 3.8 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); liver: 3 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ANKRD55,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000164542,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.4694% (minimum 75%, Missing); cerebellum: 55.3846% (minimum 75%, Missing); kidney: 71.0526% (minimum 75%, Missing); pancreas: 71.0526% (minimum 75%, Missing); parathyroid gland: 65.6535% (minimum 70%, Missing); retina: 59.8338% (minimum 75%, Missing); stomach: 66.6667% (minimum 70%, Missing)",0.144118,-0.043465,-0.196154,0,80,unavailable,17.4,11.3,5.6,"cerebellum: 17.4 nTPM (vital, limit 1); retina: 14.5 nTPM (vital, limit 1); parathyroid gland: 11.3 nTPM (protected, limit 3); stomach: 10.8 nTPM (protected, limit 3); kidney: 8.8 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); adrenal gland: 7.8 nTPM (vital, limit 1); choroid plexus: 6.4 nTPM (vital, limit 1); pituitary gland: 6.2 nTPM (vital, limit 1); hypothalamus: 5.7 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); liver: 5.3 nTPM (vital, limit 1); cerebral cortex: 5 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); bone marrow: 2.4 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MATCAP2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000164556,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP144P1,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,False,False,False,False,unchanged,
ENSG00000164611,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 51.8891% (minimum 75%, Missing); lymph node: 68.1745% (minimum 70%, Missing); thymus: 57.9449% (minimum 65%, Missing)",-0.0705512,-0.0182546,-0.231109,0,5,partial,157.9,79.5,123.6,"bone marrow: 157.9 nTPM (vital, limit 1); thymus: 123.6 nTPM (manageable, limit 5); lymph node: 79.5 nTPM (protected, limit 3); thyroid gland: 76.9 nTPM (manageable, limit 30); esophagus: 58 nTPM (protected, limit 3); rectum: 42.6 nTPM (protected, limit 3); skin: 35 nTPM (manageable, limit 5); colon: 32.7 nTPM (protected, limit 3); duodenum: 23.9 nTPM (vital, limit 1); small intestine: 23.4 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 6); spleen: 18.2 nTPM (manageable, limit 5); urinary bladder: 12.1 nTPM (protected, limit 12); hippocampal formation: 10.9 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); lung: 8.4 nTPM (vital, limit 6); cerebral cortex: 7.8 nTPM (vital, limit 6); basal ganglia: 7.5 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); liver: 5.1 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PTTG1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000164627,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 60.0000% (minimum 75%, Missing); basal ganglia: 55.4348% (minimum 75%, Missing); cerebral cortex: 56.6667% (minimum 75%, Missing); choroid plexus: 70.8333% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 50.4950% (minimum 75%, Missing); midbrain: 36.4286% (minimum 75%, Missing); retina: 63.7500% (minimum 75%, Missing); spinal cord: 40.8000% (minimum 75%, Missing)",0.260714,0.262264,-0.385714,0,7,partial,8.9,0.3,0.5,"midbrain: 8.9 nTPM (vital, limit 1); spinal cord: 7.4 nTPM (vital, limit 1); hippocampal formation: 5.1 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); amygdala: 3.4 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KIF6,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000164645,True,compatible,,True,True,True,,0.346454,0.3,0.246454,0,80,unavailable,0.1,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX47,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000164663,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.6667% (minimum 65%, Uncertain); adrenal gland: 63.5135% (minimum 75%, Missing); amygdala: 59.4937% (minimum 75%, Missing); basal ganglia: 61.0390% (minimum 75%, Missing); bone marrow: 48.9583% (minimum 75%, Missing); cerebellum: 43.1193% (minimum 75%, Missing); cerebral cortex: 54.6512% (minimum 75%, Missing); colon: 65.2778% (minimum 70%, Missing); duodenum: 74.6032% (minimum 75%, Missing); heart muscle: 70.1493% (minimum 75%, Missing); hippocampal formation: 58.7500% (minimum 75%, Missing); hypothalamus: 57.3171% (minimum 75%, Missing); kidney: 71.2121% (minimum 75%, Missing); liver: 74.6032% (minimum 75%, Missing); lung: 63.5135% (minimum 75%, Missing); lymph node: 66.1972% (minimum 70%, Missing); midbrain: 65.2778% (minimum 75%, Missing); pancreas: 71.2121% (minimum 75%, Missing); pituitary gland: 63.5135% (minimum 75%, Missing); retina: 35.0746% (minimum 75%, Missing); skeletal muscle: 63.5135% (minimum 75%, Missing); skin: 61.8421% (minimum 65%, Missing); small intestine: 73.4375% (minimum 75%, Missing); spinal cord: 65.2778% (minimum 75%, Missing); thymus: 42.7273% (minimum 65%, Missing); thyroid gland: 40.8696% (minimum 65%, Missing); urinary bladder: 66.1972% (minimum 70%, Missing)",-0.241304,-0.0472222,-0.399254,0,3,partial,8.7,2.5,6.8,"retina: 8.7 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); thymus: 6.3 nTPM (manageable, limit 5); cerebellum: 6.2 nTPM (vital, limit 1); bone marrow: 4.9 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,USP49,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000164675,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.268079,0.253079,0.168079,0,80,unavailable,2.9,1.6,2.9,"kidney: 2.9 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IQUB,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000164729,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.208333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,SLC35G3,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000164744,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.247531,0,3,partial,0.1,0,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced),52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 1 / keratinocytes,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SUN3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000164746,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 63.8095% (minimum 75%, Missing)",0.35,0.3,-0.111905,0,3,partial,7.6,0.8,0.2,"choroid plexus: 7.6 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C7orf57,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000164796,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 34.6154% (minimum 75%, Missing); basal ganglia: 31.0345% (minimum 75%, Missing); cerebellum: 64.2857% (minimum 75%, Missing); cerebral cortex: 25.0000% (minimum 75%, Missing); hippocampal formation: 36.0000% (minimum 75%, Missing); hypothalamus: 30.0000% (minimum 75%, Missing); midbrain: 52.9412% (minimum 75%, Missing); retina: 60.0000% (minimum 75%, Missing); spinal cord: 64.2857% (minimum 75%, Missing)",0.1,0.3,-0.5,0,80,unavailable,2.7,0,0.3,"cerebral cortex: 2.7 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CSMD3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000164815,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 66.4311% (minimum 75%, Missing); amygdala: 74.0157% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 59.6825% (minimum 75%, Missing); cerebral cortex: 63.5135% (minimum 75%, Missing); colon: 61.8421% (minimum 70%, Missing); duodenum: 69.6296% (minimum 75%, Missing); esophagus: 64.6048% (minimum 70%, Missing); hippocampal formation: 69.8885% (minimum 75%, Missing); hypothalamus: 68.6131% (minimum 75%, Missing); kidney: 65.2778% (minimum 75%, Missing); liver: 52.6611% (minimum 75%, Missing); lymph node: 61.2378% (minimum 70%, Missing); midbrain: 74.0157% (minimum 75%, Missing); pancreas: 57.3171% (minimum 75%, Missing); pituitary gland: 72.0307% (minimum 75%, Missing); rectum: 60.2564% (minimum 70%, Missing); retina: 57.8462% (minimum 75%, Missing); salivary gland: 68.6131% (minimum 70%, Missing); skeletal muscle: 68.3636% (minimum 75%, Missing); skin: 62.6667% (minimum 65%, Missing); small intestine: 72.0307% (minimum 75%, Missing); smooth muscle: 64.1638% (minimum 75%, Missing); stomach: 65.2778% (minimum 70%, Missing); thymus: 59.3060% (minimum 65%, Missing); urinary bladder: 63.9456% (minimum 70%, Missing)",-0.0569401,-0.0974359,-0.223389,0,0,routine_complete,16.9,12.4,12.9,"liver: 16.9 nTPM (vital, limit 1); pancreas: 14 nTPM (vital, limit 1); retina: 13.7 nTPM (vital, limit 1); thymus: 12.9 nTPM (manageable, limit 5); cerebellum: 12.7 nTPM (vital, limit 1); rectum: 12.4 nTPM (protected, limit 3); lymph node: 11.9 nTPM (protected, limit 3); colon: 11.6 nTPM (protected, limit 3); skin: 11.2 nTPM (manageable, limit 5); cerebral cortex: 10.8 nTPM (vital, limit 1); urinary bladder: 10.6 nTPM (protected, limit 3); smooth muscle: 10.5 nTPM (vital, limit 1); esophagus: 10.3 nTPM (protected, limit 3); kidney: 10 nTPM (vital, limit 1); stomach: 10 nTPM (protected, limit 3); thyroid gland: 9.9 nTPM (manageable, limit 5); parathyroid gland: 9.8 nTPM (protected, limit 4); adrenal gland: 9.5 nTPM (vital, limit 1); adipose tissue: 9.4 nTPM (manageable, limit 5); basal ganglia: 9.4 nTPM (vital, limit 1); spleen: 8.8 nTPM (manageable, limit 5); skeletal muscle: 8.7 nTPM (vital, limit 1); salivary gland: 8.6 nTPM (protected, limit 3); hypothalamus: 8.6 nTPM (vital, limit 1); duodenum: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); tongue: 7.6 nTPM (protected, limit 3); small intestine: 7.3 nTPM (vital, limit 1); pituitary gland: 7.3 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); lung: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); heart muscle: 6.1 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 1); choroid plexus: 5.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ORC5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000164871,True,compatible,,True,True,True,,0.35,0.3,0.249837,0,3,partial,0.2,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPAG11B,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000164898,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 57.9487% (minimum 60%, Approved); adrenal gland: 50.4464% (minimum 75%, Missing); amygdala: 46.6942% (minimum 75%, Missing); basal ganglia: 44.8413% (minimum 75%, Missing); bone marrow: 65.6977% (minimum 70%, Approved); cerebellum: 63.4831% (minimum 75%, Missing); cerebral cortex: 50.6726% (minimum 75%, Missing); choroid plexus: 32.0113% (minimum 75%, Missing); colon: 54.5894% (minimum 70%, Missing); duodenum: 62.7778% (minimum 75%, Missing); esophagus: 67.6647% (minimum 70%, Missing); heart muscle: 29.0488% (minimum 75%, Missing); hippocampal formation: 48.2906% (minimum 75%, Missing); hypothalamus: 47.4790% (minimum 75%, Missing); kidney: 41.6974% (minimum 75%, Missing); liver: 39.5105% (minimum 75%, Missing); lung: 69.3252% (minimum 75%, Missing); lymph node: 68.0723% (minimum 70%, Missing); midbrain: 46.3115% (minimum 75%, Missing); pancreas: 53.0516% (minimum 75%, Missing); parathyroid gland: 51.3636% (minimum 70%, Missing); pituitary gland: 49.1304% (minimum 75%, Missing); rectum: 69.7531% (minimum 70%, Missing); salivary gland: 48.0851% (minimum 70%, Missing); skeletal muscle: 28.0397% (minimum 70%, Approved); small intestine: 62.4309% (minimum 75%, Missing); spinal cord: 50.0000% (minimum 75%, Missing); stomach: 50.6726% (minimum 70%, Missing); thymus: 60.7527% (minimum 65%, Missing); thyroid gland: 52.0737% (minimum 65%, Missing); tongue: 23.3471% (minimum 70%, Missing); urinary bladder: 57.6531% (minimum 70%, Missing)",-0.129263,-0.466529,-0.459512,0,5,partial,29,37.1,10.4,"tongue: 37.1 nTPM (protected, limit 3); skeletal muscle: 29 nTPM (vital, limit 2); heart muscle: 27.6 nTPM (vital, limit 1); choroid plexus: 24 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); kidney: 15.8 nTPM (vital, limit 1); basal ganglia: 13.9 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); salivary gland: 12.2 nTPM (protected, limit 3); hippocampal formation: 12.1 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); spinal cord: 11.3 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 11 nTPM (protected, limit 3); cerebral cortex: 11 nTPM (vital, limit 1); parathyroid gland: 10.7 nTPM (protected, limit 3); thyroid gland: 10.4 nTPM (manageable, limit 5); pancreas: 10 nTPM (vital, limit 1); colon: 9.4 nTPM (protected, limit 3); urinary bladder: 8.3 nTPM (protected, limit 3); thymus: 7.3 nTPM (manageable, limit 5); small intestine: 6.8 nTPM (vital, limit 1); duodenum: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 2); esophagus: 5.4 nTPM (protected, limit 3); lymph node: 5.3 nTPM (protected, limit 3); lung: 5 nTPM (vital, limit 1); rectum: 4.9 nTPM (protected, limit 3); smooth muscle: 3.6 nTPM (vital, limit 2); retina: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FMC1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000164900,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 31.4465% (minimum 70%, Approved)",0.35,0.133333,-0.385535,0,4,partial,10.9,1,0,"skeletal muscle: 10.9 nTPM (vital, limit 2)",,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GBX1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000164944,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 58.4192% (minimum 65%, Missing); adrenal gland: 69.1057% (minimum 75%, Missing); bone marrow: 38.6364% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing); cerebral cortex: 69.1057% (minimum 75%, Missing); colon: 63.9098% (minimum 70%, Missing); duodenum: 68.2731% (minimum 75%, Missing); esophagus: 64.3939% (minimum 70%, Missing); heart muscle: 63.9098% (minimum 70%, Approved); kidney: 61.8182% (minimum 75%, Missing); liver: 58.4192% (minimum 70%, Approved); lung: 62.0438% (minimum 75%, Missing); lymph node: 54.6624% (minimum 70%, Missing); pancreas: 62.9630% (minimum 75%, Missing); parathyroid gland: 54.3131% (minimum 70%, Missing); pituitary gland: 73.5931% (minimum 75%, Missing); rectum: 60.0707% (minimum 70%, Missing); retina: 58.6207% (minimum 75%, Missing); salivary gland: 64.6388% (minimum 65%, Approved); skeletal muscle: 66.9291% (minimum 75%, Missing); skin: 64.3939% (minimum 65%, Missing); small intestine: 65.8915% (minimum 75%, Missing); smooth muscle: 55.9211% (minimum 70%, Approved); spinal cord: 73.5931% (minimum 75%, Missing); spleen: 60.4982% (minimum 65%, Missing); stomach: 60.0707% (minimum 70%, Missing); thymus: 46.5753% (minimum 65%, Missing); thyroid gland: 56.8562% (minimum 65%, Missing); tongue: 65.6371% (minimum 70%, Missing); urinary bladder: 62.7306% (minimum 70%, Missing)",-0.184247,-0.156869,-0.363636,0,5,partial,27,14.3,19.5,"bone marrow: 27 nTPM (vital, limit 1); thymus: 19.5 nTPM (manageable, limit 5); parathyroid gland: 14.3 nTPM (protected, limit 3); lymph node: 14.1 nTPM (protected, limit 3); smooth muscle: 13.4 nTPM (vital, limit 2); thyroid gland: 12.9 nTPM (manageable, limit 5); adipose tissue: 12.1 nTPM (manageable, limit 5); liver: 12.1 nTPM (vital, limit 2); retina: 12 nTPM (vital, limit 1); stomach: 11.3 nTPM (protected, limit 3); rectum: 11.3 nTPM (protected, limit 3); spleen: 11.1 nTPM (manageable, limit 5); kidney: 10.5 nTPM (vital, limit 1); lung: 10.4 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 3); pancreas: 10 nTPM (vital, limit 1); colon: 9.6 nTPM (protected, limit 3); heart muscle: 9.6 nTPM (vital, limit 2); esophagus: 9.4 nTPM (protected, limit 3); skin: 9.4 nTPM (manageable, limit 5); salivary gland: 9.3 nTPM (protected, limit 4); tongue: 8.9 nTPM (protected, limit 3); small intestine: 8.8 nTPM (vital, limit 1); cerebellum: 8.5 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); duodenum: 7.9 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,VIRMA,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000164975,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.2000% (minimum 65%, Missing); adrenal gland: 50.0000% (minimum 75%, Missing); amygdala: 55.6338% (minimum 75%, Missing); basal ganglia: 56.8345% (minimum 75%, Missing); cerebellum: 43.6464% (minimum 75%, Missing); cerebral cortex: 53.7415% (minimum 75%, Missing); choroid plexus: 56.4286% (minimum 75%, Missing); colon: 58.5185% (minimum 70%, Missing); duodenum: 66.9492% (minimum 75%, Missing); esophagus: 53.3784% (minimum 70%, Missing); heart muscle: 40.5128% (minimum 75%, Missing); hippocampal formation: 54.4828% (minimum 75%, Missing); hypothalamus: 58.5185% (minimum 75%, Missing); kidney: 63.7097% (minimum 75%, Missing); liver: 68.1034% (minimum 75%, Missing); lung: 65.2893% (minimum 75%, Missing); midbrain: 56.8345% (minimum 75%, Missing); pancreas: 60.7692% (minimum 75%, Missing); parathyroid gland: 55.6338% (minimum 70%, Missing); pituitary gland: 61.2403% (minimum 75%, Missing); rectum: 65.2893% (minimum 70%, Missing); retina: 56.4286% (minimum 75%, Missing); salivary gland: 64.2276% (minimum 70%, Missing); skeletal muscle: 45.9302% (minimum 75%, Missing); small intestine: 62.6984% (minimum 75%, Missing); smooth muscle: 56.0284% (minimum 75%, Missing); spinal cord: 56.4286% (minimum 75%, Missing); stomach: 63.2000% (minimum 70%, Missing); thyroid gland: 64.7541% (minimum 65%, Missing); tongue: 40.9326% (minimum 70%, Missing); urinary bladder: 61.7188% (minimum 70%, Missing)",-0.018,-0.290674,-0.344872,0,80,unavailable,11.6,11.4,4.6,"heart muscle: 11.6 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 3); cerebellum: 10.2 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 1); adrenal gland: 7.9 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 3); cerebral cortex: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); amygdala: 6.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 3); smooth muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 3); hypothalamus: 5.6 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); urinary bladder: 4.9 nTPM (protected, limit 3); small intestine: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); kidney: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 3); rectum: 4.2 nTPM (protected, limit 3); lung: 4.2 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); lymph node: 3.2 nTPM (protected, limit 3); bone marrow: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SNAPC3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000164989,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 67.7019% (minimum 75%, Missing)",0.0487179,0.186179,-0.0729814,0,0,routine_complete,5.2,1.4,4.7,"retina: 5.2 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC171,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000165059,True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRKACG,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000165076,True,compatible,,True,True,True,,0.340123,0.3,0.247512,0,2,partial,0.1,0,0.4,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRSS37,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000165113,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.306265,0.184144,0.148016,0,14,partial,48.5,25.5,9.6,"skeletal muscle: 48.5 nTPM (vital, limit 6); tongue: 25.5 nTPM (protected, limit 3); retina: 22.1 nTPM (vital, limit 1); cerebellum: 18.6 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 6); midbrain: 14.4 nTPM (vital, limit 1); hypothalamus: 14.1 nTPM (vital, limit 1); spinal cord: 13.1 nTPM (vital, limit 1); amygdala: 12.2 nTPM (vital, limit 1); pituitary gland: 12.2 nTPM (vital, limit 1); colon: 11.7 nTPM (protected, limit 3); hippocampal formation: 10.6 nTPM (vital, limit 1); cerebral cortex: 10.4 nTPM (vital, limit 6); basal ganglia: 10.4 nTPM (vital, limit 1); liver: 9.2 nTPM (vital, limit 6); thymus: 8.9 nTPM (manageable, limit 5); pancreas: 8.3 nTPM (vital, limit 6); kidney: 7.2 nTPM (vital, limit 6); adrenal gland: 6.3 nTPM (vital, limit 6); small intestine: 5.2 nTPM (vital, limit 1); duodenum: 4.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3)",cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GKAP1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000165120,True,compatible,,True,True,True,,0.35,0.3,0.246825,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SSMEM1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000165131,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333155,0.296894,0.225684,0,80,unavailable,1.6,0.2,1.1,"bone marrow: 1.6 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LLCFC1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000165181,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.336111,0.250893,0.102,0,80,unavailable,3.7,1.1,0.3,"adrenal gland: 3.7 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SHOC1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000165182,True,compatible,,True,True,True,,0.276829,0.25,0.154762,0,80,unavailable,0.4,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CXorf58,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000165188,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 58.5185% (minimum 75%, Missing)",0.325309,0.00535714,-0.164815,0,80,unavailable,11.2,6.6,0.4,"kidney: 11.2 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 3); esophagus: 4.8 nTPM (protected, limit 3); stomach: 3.3 nTPM (protected, limit 3); pituitary gland: 1.9 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RNF183,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000165204,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR1K1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000165244,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 18.6120% (minimum 75%, Missing); colon: 67.0455% (minimum 70%, Missing); duodenum: 67.8161% (minimum 75%, Missing); heart muscle: 74.6835% (minimum 75%, Missing); kidney: 67.0455% (minimum 75%, Missing); liver: 35.9756% (minimum 75%, Missing); lymph node: 57.2816% (minimum 70%, Uncertain); rectum: 64.8352% (minimum 70%, Uncertain); skin: 63.4409% (minimum 65%, Missing); small intestine: 67.0455% (minimum 75%, Missing); smooth muscle: 71.9512% (minimum 75%, Uncertain); thymus: 41.2587% (minimum 65%, Missing); tongue: 69.4118% (minimum 70%, Missing)",-0.237413,-0.127184,-0.56388,0,3,partial,25.8,4.4,8.4,"bone marrow: 25.8 nTPM (vital, limit 1); liver: 10.5 nTPM (vital, limit 1); thymus: 8.4 nTPM (manageable, limit 5); lymph node: 4.4 nTPM (protected, limit 3); rectum: 3.2 nTPM (protected, limit 3); kidney: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF367,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000165309,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 46.2446% (minimum 75%, Missing)",0.347685,0.297685,-0.287554,0,4,partial,50.1,0.1,0.3,"choroid plexus: 50.1 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ARMC3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000165325,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.296429,0.281481,0.169075,0,80,unavailable,1.4,0.3,0.9,"pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DEUP1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000165383,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 35.5795% (minimum 75%, Missing)",0.35,0.3,-0.394205,0,4,partial,23.9,0.6,0.7,"choroid plexus: 23.9 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / basal cells: Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRRC18,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000165480,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 56.4815% (minimum 70%, Approved); lymph node: 59.2233% (minimum 65%, Approved); thymus: 34.0782% (minimum 65%, Missing)",-0.309218,-0.057767,-0.135185,0,3,partial,4.7,4.2,11.8,"thymus: 11.8 nTPM (manageable, limit 5); bone marrow: 4.7 nTPM (vital, limit 2); lymph node: 4.2 nTPM (protected, limit 4)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SKA3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000165490,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 57.9235% (minimum 75%, Missing)",0.0208861,0.0114094,-0.170765,0,6,partial,7.7,4.3,5.2,"bone marrow: 7.7 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 4.3 nTPM (protected, limit 3); lung: 3.3 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); smooth muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DDIAS,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000165496,True,compatible,,True,True,True,,0.35,0.271739,0.243333,0,80,unavailable,0.6,2.6,0,,,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RPL10L,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,True,True,True,gained,grid_revised
ENSG00000165555,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 61.4679% (minimum 75%, Missing)",0.293662,0.280556,-0.135321,0,3,partial,4.2,0.5,0.6,"retina: 4.2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NOXRED1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000165568,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.201852,0.224623,0.0979263,0,2,partial,3.3,1.5,3.2,"retina: 3.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AKR1E2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000165583,True,compatible,,True,True,True,,0.116667,0.1,0.0166667,0,3,partial,0.2,0.1,0.2,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SSX5,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,False,gained,selectivity_revised
ENSG00000165584,True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0.1,0,0.2,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SSX3,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000165643,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 65.8635% (minimum 75%, Missing); cerebral cortex: 28.2759% (minimum 75%, Missing); hippocampal formation: 46.5909% (minimum 75%, Missing)",0.320414,0.293939,-0.467241,0,80,unavailable,41.6,0.1,0.5,"cerebral cortex: 41.6 nTPM (vital, limit 1); hippocampal formation: 18.8 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SOHLH1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000165695,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 71.6332% (minimum 75%, Missing)",0.293396,0.292063,-0.0336676,0,7,partial,9.9,3,4.6,"choroid plexus: 9.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); kidney / distal tubules: Low (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AK8,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000165698,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.293089,0.286852,0.12099,0,6,partial,18.9,11.1,15.2,"choroid plexus: 18.9 nTPM (vital, limit 1); hypothalamus: 18.4 nTPM (vital, limit 1); basal ganglia: 17.7 nTPM (vital, limit 1); spinal cord: 16.8 nTPM (vital, limit 1); midbrain: 15.9 nTPM (vital, limit 1); cerebral cortex: 14.9 nTPM (vital, limit 6); amygdala: 14.6 nTPM (vital, limit 1); hippocampal formation: 14.3 nTPM (vital, limit 1); kidney: 11.9 nTPM (vital, limit 6); pituitary gland: 11.2 nTPM (vital, limit 1); heart muscle: 10 nTPM (vital, limit 6); cerebellum: 8.6 nTPM (vital, limit 6); retina: 7.9 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); adrenal gland: 7.4 nTPM (vital, limit 6); lung: 7.2 nTPM (vital, limit 6)",bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPACA9,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000165805,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C12orf50,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000165807,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344475,0.151064,0.0990566,0,13,partial,10.4,7,1.9,"pancreas: 10.4 nTPM (vital, limit 6); duodenum: 6.4 nTPM (vital, limit 1); colon: 6.3 nTPM (protected, limit 3); rectum: 5.4 nTPM (protected, limit 3); choroid plexus: 4.8 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); colon / enterocytes - Microvilli: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); small intestine / enterocytes - Microvilli: Medium (Enhanced),77,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PPP1R36,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000165828,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 16.8079% (minimum 75%, Missing); colon: 14.1667% (minimum 70%, Missing); duodenum: 1.1500% (minimum 75%, Missing); kidney: 7.8444% (minimum 75%, Missing); liver: 1.7881% (minimum 75%, Missing); rectum: 25.6466% (minimum 70%, Missing); small intestine: 1.0666% (minimum 75%, Missing)",0.32541,-0.558333,-0.739334,0,5,partial,1103.8,72.1,1.3,"small intestine: 1103.8 nTPM (vital, limit 1); duodenum: 1022.9 nTPM (vital, limit 1); liver: 653.6 nTPM (vital, limit 1); kidney: 139.8 nTPM (vital, limit 1); colon: 72.1 nTPM (protected, limit 3); choroid plexus: 58.9 nTPM (vital, limit 1); rectum: 34.5 nTPM (protected, limit 3)",duodenum / glandular cells: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / hepatocytes: Medium (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: Medium (Supported),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRAP1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000165837,True,compatible,,True,True,True,,0.35,0.3,0.154762,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ERICH6B,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000165863,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.332079,0.28917,0.229738,0,80,unavailable,1.7,0.9,1.5,"adrenal gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPMIP5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000165891,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 36.3636% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); lymph node: 65.1163% (minimum 70%, Missing); rectum: 66.6667% (minimum 70%, Missing); thymus: 25.9259% (minimum 65%, Missing)",-0.390741,-0.0488372,-0.386364,0,80,unavailable,4.9,1.5,8,"thymus: 8 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,E2F7,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000165923,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.245522,0.216031,0.0553691,0,7,partial,2.9,1.1,1.4,"liver: 2.9 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AGBL2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000165970,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 30.0000% (minimum 75%, Missing); cerebral cortex: 75.0000% (minimum 75%, Missing); lung: 25.0000% (minimum 75%, Missing); pituitary gland: 33.3333% (minimum 75%, Missing); spinal cord: 27.2727% (minimum 75%, Missing)",0.35,0.3,-0.5,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC6A5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000165972,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308824,0.287879,0.107895,0,80,unavailable,2.7,0.2,0.7,"liver: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC38,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000166024,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 72.6619% (minimum 75%, Missing); liver: 69.6552% (minimum 75%, Missing); lung: 74.0831% (minimum 75%, Missing); pancreas: 73.9024% (minimum 75%, Missing); small intestine: 71.6312% (minimum 75%, Missing)",0.020354,0.00465116,-0.0534483,0,2,partial,17.2,12.7,14.9,"bone marrow: 17.2 nTPM (vital, limit 6); spleen: 14.9 nTPM (manageable, limit 5); skin: 14.6 nTPM (manageable, limit 5); thymus: 13.3 nTPM (manageable, limit 5); liver: 13.2 nTPM (vital, limit 1); esophagus: 12.7 nTPM (protected, limit 3); urinary bladder: 12 nTPM (protected, limit 3); small intestine: 12 nTPM (vital, limit 1); lymph node: 11.9 nTPM (protected, limit 3); colon: 11.7 nTPM (protected, limit 3); salivary gland: 11.5 nTPM (protected, limit 3); kidney: 11.4 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); lung: 10.6 nTPM (vital, limit 1); parathyroid gland: 10.2 nTPM (protected, limit 3); thyroid gland: 9.8 nTPM (manageable, limit 5); rectum: 9.8 nTPM (protected, limit 3); retina: 9.7 nTPM (vital, limit 1); skeletal muscle: 9.5 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 3); spinal cord: 9 nTPM (vital, limit 1); choroid plexus: 8.8 nTPM (vital, limit 1); pituitary gland: 8.4 nTPM (vital, limit 1); adrenal gland: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 3); midbrain: 7.3 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); hippocampal formation: 6.8 nTPM (vital, limit 1); amygdala: 6.4 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); smooth muscle: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,R3HCC1L,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000166049,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PASD1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000166068,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5292% (minimum 60%, Approved); adrenal gland: 63.0841% (minimum 75%, Missing); amygdala: 48.3871% (minimum 75%, Missing); basal ganglia: 45.0000% (minimum 75%, Missing); cerebellum: 71.0526% (minimum 75%, Missing); cerebral cortex: 40.2985% (minimum 75%, Missing); colon: 55.1020% (minimum 70%, Missing); duodenum: 62.7907% (minimum 70%, Approved); esophagus: 69.5876% (minimum 70%, Missing); heart muscle: 65.5340% (minimum 75%, Missing); hippocampal formation: 51.1364% (minimum 75%, Missing); hypothalamus: 57.9399% (minimum 75%, Missing); kidney: 60.5381% (minimum 75%, Missing); liver: 71.4286% (minimum 75%, Missing); lung: 44.4079% (minimum 75%, Missing); midbrain: 54.2169% (minimum 75%, Missing); parathyroid gland: 67.1642% (minimum 70%, Missing); rectum: 56.0166% (minimum 70%, Missing); retina: 65.2174% (minimum 75%, Missing); small intestine: 62.5000% (minimum 75%, Missing); smooth muscle: 59.4714% (minimum 70%, Approved); spinal cord: 53.7849% (minimum 75%, Missing); stomach: 57.4468% (minimum 70%, Missing); thyroid gland: 30.8924% (minimum 65%, Missing); tongue: 63.6792% (minimum 70%, Missing); urinary bladder: 51.5267% (minimum 70%, Missing)",-0.341076,-0.184733,-0.347015,0,3,partial,20,12.7,30.2,"thyroid gland: 30.2 nTPM (manageable, limit 5); cerebral cortex: 20 nTPM (vital, limit 1); lung: 16.9 nTPM (vital, limit 1); basal ganglia: 16.5 nTPM (vital, limit 1); amygdala: 14.4 nTPM (vital, limit 1); hippocampal formation: 12.9 nTPM (vital, limit 1); urinary bladder: 12.7 nTPM (protected, limit 3); adipose tissue: 12.2 nTPM (manageable, limit 10); spinal cord: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); colon: 11 nTPM (protected, limit 3); rectum: 10.6 nTPM (protected, limit 3); stomach: 10 nTPM (protected, limit 3); hypothalamus: 9.8 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 2); kidney: 8.8 nTPM (vital, limit 1); small intestine: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 2); adrenal gland: 7.9 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 3); retina: 7.2 nTPM (vital, limit 1); heart muscle: 7.1 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 4); parathyroid gland: 6.6 nTPM (protected, limit 3); skin: 6 nTPM (manageable, limit 5); esophagus: 5.9 nTPM (protected, limit 3); cerebellum: 5.5 nTPM (vital, limit 1); salivary gland: 5.4 nTPM (protected, limit 3); liver: 5.4 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); pituitary gland: 3.9 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPRED1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000166069,True,compatible,,True,True,True,,0.35,0.3,0.249062,0,1,partial,0.1,0.6,0,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TMCO5A,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000166086,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 68.7285% (minimum 75%, Missing); cerebral cortex: 74.2942% (minimum 75%, Missing); choroid plexus: 67.4309% (minimum 75%, Missing); colon: 65.4450% (minimum 70%, Missing); hippocampal formation: 66.0939% (minimum 75%, Missing); midbrain: 66.1376% (minimum 75%, Missing); retina: 68.1199% (minimum 75%, Missing); smooth muscle: 70.7714% (minimum 75%, Missing); spinal cord: 56.4972% (minimum 75%, Missing)",0.203971,-0.0455497,-0.185028,0,6,partial,77,52.8,22.9,"spinal cord: 77 nTPM (vital, limit 1); colon: 52.8 nTPM (protected, limit 3); hippocampal formation: 51.3 nTPM (vital, limit 1); midbrain: 51.2 nTPM (vital, limit 1); choroid plexus: 48.3 nTPM (vital, limit 1); retina: 46.8 nTPM (vital, limit 1); basal ganglia: 45.5 nTPM (vital, limit 1); smooth muscle: 41.3 nTPM (vital, limit 1); urinary bladder: 40.3 nTPM (protected, limit 3); cerebral cortex: 34.6 nTPM (vital, limit 1); amygdala: 33.1 nTPM (vital, limit 1); pituitary gland: 32.4 nTPM (vital, limit 1); hypothalamus: 31.8 nTPM (vital, limit 1); heart muscle: 30.5 nTPM (vital, limit 1); lung: 28.7 nTPM (vital, limit 2); adipose tissue: 22.9 nTPM (manageable, limit 10); small intestine: 21.9 nTPM (vital, limit 2); stomach: 21.7 nTPM (protected, limit 3); esophagus: 21.3 nTPM (protected, limit 3); adrenal gland: 19 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 4); thymus: 17.1 nTPM (manageable, limit 5); thyroid gland: 15.3 nTPM (manageable, limit 5); tongue: 14.1 nTPM (protected, limit 3); spleen: 13.2 nTPM (manageable, limit 5); cerebellum: 12.9 nTPM (vital, limit 1); salivary gland: 12.9 nTPM (protected, limit 4); skin: 12.6 nTPM (manageable, limit 10); rectum: 12.5 nTPM (protected, limit 4); kidney: 11.1 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 3); duodenum: 7.2 nTPM (vital, limit 1); skeletal muscle: 6.8 nTPM (vital, limit 2); pancreas: 5 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,JAM3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000166118,True,compatible,,True,True,True,,0.35,0.3,0.248474,0,3,partial,0.2,0.2,0,,,54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA19,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000166152,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C16orf78,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000166192,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"skeletal muscle: 71.3615% (minimum 75%, Missing)",0.106219,0.0342995,-0.036385,0,1,partial,6.1,5.5,4.9,"skeletal muscle: 6.1 nTPM (vital, limit 1); tongue: 5.5 nTPM (protected, limit 3); retina: 4.5 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SENP8,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000166206,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 46.9388% (minimum 75%, Missing); amygdala: 58.9744% (minimum 75%, Missing); basal ganglia: 32.8571% (minimum 75%, Missing); cerebellum: 31.9444% (minimum 75%, Missing); cerebral cortex: 9.1451% (minimum 75%, Missing); heart muscle: 47.4227% (minimum 75%, Missing); hippocampal formation: 53.4884% (minimum 75%, Missing); hypothalamus: 43.8095% (minimum 75%, Missing); kidney: 39.6552% (minimum 75%, Missing); midbrain: 74.1935% (minimum 75%, Missing); pancreas: 58.9744% (minimum 75%, Missing); parathyroid gland: 69.6970% (minimum 70%, Missing); pituitary gland: 45.0980% (minimum 75%, Missing); retina: 13.5693% (minimum 75%, Missing); stomach: 45.5446% (minimum 70%, Missing); thyroid gland: 35.6589% (minimum 65%, Missing)",-0.293411,-0.244554,-0.658549,0,80,unavailable,45.7,5.5,8.3,"cerebral cortex: 45.7 nTPM (vital, limit 1); retina: 29.3 nTPM (vital, limit 1); cerebellum: 9.8 nTPM (vital, limit 1); basal ganglia: 9.4 nTPM (vital, limit 1); thyroid gland: 8.3 nTPM (manageable, limit 5); kidney: 7 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); stomach: 5.5 nTPM (protected, limit 3); adrenal gland: 5.2 nTPM (vital, limit 1); heart muscle: 5.1 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); amygdala: 3.2 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GABRB3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000166220,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"thymus: 13.9423% (minimum 65%, Missing)",-0.510577,0.3,0.245098,0,80,unavailable,0.1,0,125.3,"thymus: 125.3 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TBATA,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000166246,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.341724,0.284932,0.115223,0,6,partial,11.2,1.1,1.9,"choroid plexus: 11.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAAF8,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000166263,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 64.1509% (minimum 75%, Missing); bone marrow: 70.8333% (minimum 75%, Missing); cerebral cortex: 73.9130% (minimum 75%, Missing); choroid plexus: 60.7143% (minimum 75%, Missing); colon: 68.0000% (minimum 70%, Missing); duodenum: 57.6271% (minimum 75%, Missing); esophagus: 65.3846% (minimum 70%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); kidney: 44.7368% (minimum 75%, Missing); lung: 61.8182% (minimum 75%, Missing); pancreas: 69.3878% (minimum 75%, Missing); parathyroid gland: 36.9565% (minimum 70%, Missing); pituitary gland: 64.1509% (minimum 75%, Missing); rectum: 68.0000% (minimum 70%, Missing); retina: 43.5897% (minimum 75%, Missing); small intestine: 72.3404% (minimum 75%, Missing); smooth muscle: 56.6667% (minimum 75%, Missing); stomach: 69.3878% (minimum 70%, Missing); thyroid gland: 53.1250% (minimum 65%, Missing); urinary bladder: 65.3846% (minimum 70%, Missing)",-0.11875,-0.330435,-0.314103,0,1,partial,4.4,5.8,3,"parathyroid gland: 5.8 nTPM (protected, limit 3); retina: 4.4 nTPM (vital, limit 1); kidney: 4.2 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,STXBP4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000166323,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.316601,0.282036,0.197977,0,80,unavailable,2.7,0.9,1.7,"retina: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C11orf65,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000166329,True,compatible,,True,True,True,,0.35,0.3,0.246403,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC182,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000166349,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 61.5385% (minimum 75%, Missing); bone marrow: 16.0000% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); duodenum: 50.0000% (minimum 75%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); kidney: 38.0952% (minimum 75%, Missing); liver: 53.3333% (minimum 75%, Missing); lung: 57.1429% (minimum 75%, Missing); pancreas: 72.7273% (minimum 75%, Missing); parathyroid gland: 57.1429% (minimum 70%, Missing); retina: 57.1429% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); small intestine: 44.4444% (minimum 75%, Missing); spleen: 22.8571% (minimum 65%, Missing); stomach: 61.5385% (minimum 70%, Missing); thymus: 0.2074% (minimum 65%, Missing); thyroid gland: 25.0000% (minimum 65%, Missing)",-0.647926,-0.128571,-0.59,0,80,unavailable,4.2,0.6,385,"thymus: 385 nTPM (manageable, limit 5); bone marrow: 4.2 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RAG1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000166351,True,compatible,,True,True,True,,0.304545,0.276744,0.204545,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,POTED,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000166359,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.255263,0.177551,0.101485,0,80,unavailable,1.5,1.2,0.9,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,WDR88,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000166368,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR2D2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000166439,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.9123% (minimum 65%, Missing); adrenal gland: 72.5490% (minimum 75%, Missing); bone marrow: 34.1014% (minimum 75%, Missing); cerebellum: 74.0000% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); colon: 63.7931% (minimum 70%, Missing); duodenum: 65.4867% (minimum 75%, Missing); esophagus: 43.0233% (minimum 70%, Missing); heart muscle: 70.4762% (minimum 75%, Missing); kidney: 62.1849% (minimum 75%, Missing); liver: 60.1626% (minimum 75%, Missing); lung: 56.4885% (minimum 75%, Missing); lymph node: 54.4118% (minimum 70%, Missing); pancreas: 63.2479% (minimum 75%, Missing); parathyroid gland: 57.8125% (minimum 70%, Missing); rectum: 59.2000% (minimum 70%, Missing); retina: 55.6391% (minimum 75%, Missing); salivary gland: 62.7119% (minimum 70%, Missing); skeletal muscle: 53.2374% (minimum 75%, Missing); skin: 57.8125% (minimum 65%, Missing); small intestine: 63.2479% (minimum 75%, Missing); smooth muscle: 50.3401% (minimum 75%, Missing); spleen: 50.6849% (minimum 65%, Missing); stomach: 62.1849% (minimum 70%, Missing); thymus: 49.6644% (minimum 65%, Missing); thyroid gland: 56.4885% (minimum 65%, Missing); tongue: 56.9231% (minimum 70%, Missing); urinary bladder: 59.6774% (minimum 70%, Missing)",-0.153356,-0.269767,-0.408986,0,80,unavailable,14.3,9.8,7.5,"bone marrow: 14.3 nTPM (vital, limit 1); esophagus: 9.8 nTPM (protected, limit 3); thymus: 7.5 nTPM (manageable, limit 5); smooth muscle: 7.3 nTPM (vital, limit 1); spleen: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6.5 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 3); retina: 5.9 nTPM (vital, limit 1); lung: 5.7 nTPM (vital, limit 1); thyroid gland: 5.7 nTPM (manageable, limit 5); tongue: 5.6 nTPM (protected, limit 3); skin: 5.4 nTPM (manageable, limit 5); parathyroid gland: 5.4 nTPM (protected, limit 3); rectum: 5.1 nTPM (protected, limit 3); urinary bladder: 5 nTPM (protected, limit 3); liver: 4.9 nTPM (vital, limit 1); stomach: 4.5 nTPM (protected, limit 3); kidney: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 3); small intestine: 4.3 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 3); duodenum: 3.9 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RNF169,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000166546,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 63.6364% (minimum 75%, Missing); cerebellum: 63.6364% (minimum 75%, Missing); cerebral cortex: 38.8889% (minimum 75%, Missing); heart muscle: 70.0000% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 56.0000% (minimum 75%, Missing); retina: 58.3333% (minimum 75%, Missing)",0.05,0.0368421,-0.361111,0,80,unavailable,2.2,0.5,0.6,"cerebral cortex: 2.2 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BEAN1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000166578,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 66.7702% (minimum 75%, Missing)",0.333982,0.283982,-0.0822981,0,4,partial,21.4,4.9,1.7,"choroid plexus: 21.4 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); retina: 3.6 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IQCD,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000166743,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340539,0.289603,0.205292,0,80,unavailable,9.8,2.2,2,"liver: 9.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ACSM1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000166796,True,compatible,,True,True,True,,0.349224,0.299224,0.248836,0,2,partial,1.4,0.4,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LDHC,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,False,unchanged,
ENSG00000166800,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.258163,0.256989,0.14,0,80,unavailable,1.1,0.4,0.9,"retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LDHAL6A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000166845,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.181683,0.152792,0.125,0,80,unavailable,2.4,2.9,3.4,"spinal cord: 2.4 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C18orf54,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000166851,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 50.3925% (minimum 75%, Missing); lymph node: 54.1315% (minimum 70%, Missing); thymus: 42.9144% (minimum 65%, Missing)",-0.220856,-0.158685,-0.246075,0,4,partial,31.6,27.2,42.7,"thymus: 42.7 nTPM (manageable, limit 5); bone marrow: 31.6 nTPM (vital, limit 1); lymph node: 27.2 nTPM (protected, limit 3); esophagus: 13.5 nTPM (protected, limit 3); duodenum: 10.1 nTPM (vital, limit 1); rectum: 9.8 nTPM (protected, limit 3); colon: 9.3 nTPM (protected, limit 3); small intestine: 8.9 nTPM (vital, limit 1); stomach: 6 nTPM (protected, limit 3); skin: 5.6 nTPM (manageable, limit 5); smooth muscle: 3.8 nTPM (vital, limit 1); cerebellum: 3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PLK1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000166884,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR4D6,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000166926,True,compatible,,True,True,True,,0.200427,0.29005,0.220732,0,80,unavailable,0.6,0.2,3.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MS4A6E,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000166928,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.345792,0.295792,0.187913,0,1,partial,11.6,2.6,10.2,"lung: 11.6 nTPM (vital, limit 6); choroid plexus: 4.7 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MS4A14,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000166930,True,compatible,,True,True,True,,0.35,0.3,0.245402,0,0,routine_complete,0.2,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MS4A5,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000167014,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.168103,0,80,unavailable,1.9,0,0,"liver: 1.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TERB2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000167094,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.34359,0.274843,0.183735,0,80,unavailable,1.1,0.4,0.1,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TTC16,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000167098,True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SUN5,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000167139,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TBC1D21,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000167194,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 30.0403% (minimum 75%, Missing)",0.35,0.293333,-0.449597,0,80,unavailable,34.7,0.1,0,"retina: 34.7 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C16orf92,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000167195,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.289796,0.0738806,0,1,partial,3.7,0.1,0.2,"liver: 3.7 nTPM (vital, limit 3)",,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GOLGA6C,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000167210,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.260204,0.291111,0.0189655,0,80,unavailable,6.7,0.2,2.2,"kidney: 6.7 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,gallbladder; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LOXHD1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000167311,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 68.7500% (minimum 75%, Missing)",0.263738,0.0409326,-0.0625,0,80,unavailable,13,10,2.7,"skeletal muscle: 13 nTPM (vital, limit 1); tongue: 10 nTPM (protected, limit 3); choroid plexus: 2.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ART5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000167360,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR51Q1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000167377,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 59.2308% (minimum 65%, Missing); adrenal gland: 65.2542% (minimum 75%, Missing); amygdala: 58.3333% (minimum 75%, Missing); basal ganglia: 57.8947% (minimum 75%, Missing); bone marrow: 64.1667% (minimum 75%, Missing); cerebellum: 42.3077% (minimum 75%, Missing); cerebral cortex: 54.6099% (minimum 75%, Missing); choroid plexus: 33.3333% (minimum 75%, Missing); colon: 58.7786% (minimum 70%, Missing); duodenum: 72.6415% (minimum 75%, Missing); esophagus: 65.8120% (minimum 70%, Missing); heart muscle: 60.6299% (minimum 75%, Missing); hippocampal formation: 55.3957% (minimum 75%, Missing); hypothalamus: 56.2044% (minimum 75%, Missing); kidney: 58.3333% (minimum 75%, Missing); liver: 59.6899% (minimum 75%, Missing); lung: 59.6899% (minimum 75%, Missing); lymph node: 56.2044% (minimum 70%, Missing); midbrain: 61.1111% (minimum 75%, Missing); pancreas: 63.6364% (minimum 75%, Missing); parathyroid gland: 60.6299% (minimum 70%, Missing); pituitary gland: 35.6481% (minimum 75%, Missing); rectum: 58.7786% (minimum 70%, Missing); retina: 33.4783% (minimum 75%, Missing); salivary gland: 64.7059% (minimum 70%, Missing); skeletal muscle: 53.8462% (minimum 75%, Missing); skin: 58.3333% (minimum 65%, Missing); small intestine: 61.1111% (minimum 75%, Missing); smooth muscle: 53.8462% (minimum 75%, Missing); spinal cord: 57.0370% (minimum 75%, Missing); spleen: 57.8947% (minimum 65%, Missing); stomach: 65.8120% (minimum 70%, Missing); thymus: 62.6016% (minimum 65%, Missing); thyroid gland: 51.6779% (minimum 65%, Missing); tongue: 52.7397% (minimum 70%, Missing); urinary bladder: 65.2542% (minimum 70%, Missing)",-0.133221,-0.172603,-0.416667,0,80,unavailable,15.4,6.9,7.2,"choroid plexus: 15.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); pituitary gland: 13.9 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); thyroid gland: 7.2 nTPM (manageable, limit 5); tongue: 6.9 nTPM (protected, limit 3); skeletal muscle: 6.6 nTPM (vital, limit 1); smooth muscle: 6.6 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 3); hypothalamus: 6 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); basal ganglia: 5.6 nTPM (vital, limit 1); kidney: 5.5 nTPM (vital, limit 1); skin: 5.5 nTPM (manageable, limit 5); amygdala: 5.5 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 3); rectum: 5.4 nTPM (protected, limit 3); adipose tissue: 5.3 nTPM (manageable, limit 5); lung: 5.2 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); parathyroid gland: 5 nTPM (protected, limit 3); heart muscle: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); small intestine: 4.9 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.3 nTPM (vital, limit 1); salivary gland: 4.2 nTPM (protected, limit 3); adrenal gland: 4.1 nTPM (vital, limit 1); urinary bladder: 4.1 nTPM (protected, limit 3); esophagus: 4 nTPM (protected, limit 3); stomach: 4 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF23,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000167394,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.4803% (minimum 65%, Missing); adrenal gland: 53.2847% (minimum 75%, Missing); amygdala: 55.7252% (minimum 75%, Missing); basal ganglia: 54.4776% (minimum 75%, Missing); bone marrow: 48.3444% (minimum 75%, Missing); cerebellum: 50.3448% (minimum 75%, Missing); cerebral cortex: 50.3448% (minimum 75%, Missing); colon: 57.4803% (minimum 70%, Missing); duodenum: 62.9310% (minimum 75%, Missing); esophagus: 54.0741% (minimum 70%, Missing); heart muscle: 57.0312% (minimum 75%, Missing); hippocampal formation: 53.2847% (minimum 75%, Missing); hypothalamus: 57.4803% (minimum 75%, Missing); kidney: 62.9310% (minimum 75%, Missing); liver: 60.8333% (minimum 75%, Missing); lung: 62.9310% (minimum 75%, Missing); midbrain: 59.8361% (minimum 75%, Missing); pancreas: 65.7658% (minimum 75%, Missing); pituitary gland: 60.3306% (minimum 75%, Missing); salivary gland: 61.8644% (minimum 70%, Missing); skeletal muscle: 55.3030% (minimum 75%, Missing); skin: 50.6944% (minimum 65%, Missing); small intestine: 60.8333% (minimum 75%, Missing); smooth muscle: 68.8679% (minimum 75%, Missing); spinal cord: 59.3496% (minimum 75%, Missing); spleen: 55.7252% (minimum 65%, Missing); stomach: 61.3445% (minimum 70%, Missing); thyroid gland: 64.6018% (minimum 65%, Missing); urinary bladder: 54.8872% (minimum 70%, Missing)",-0.143056,-0.159259,-0.266556,0,2,partial,7.8,6.2,7.1,"bone marrow: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 1); skin: 7.1 nTPM (manageable, limit 5); adrenal gland: 6.4 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); esophagus: 6.2 nTPM (protected, limit 3); basal ganglia: 6.1 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 3); skeletal muscle: 5.9 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); spleen: 5.8 nTPM (manageable, limit 5); heart muscle: 5.5 nTPM (vital, limit 1); adipose tissue: 5.4 nTPM (manageable, limit 5); hypothalamus: 5.4 nTPM (vital, limit 1); colon: 5.4 nTPM (protected, limit 3); spinal cord: 5 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1); pituitary gland: 4.8 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); small intestine: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); salivary gland: 4.5 nTPM (protected, limit 3); lung: 4.3 nTPM (vital, limit 1); duodenum: 4.3 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF668,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000167395,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 73.3138% (minimum 75%, Uncertain)",0.100751,0.08125,-0.0168622,0,2,partial,9.1,7,8.3,"bone marrow: 9.1 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); spleen: 7.8 nTPM (manageable, limit 5); skin: 7.8 nTPM (manageable, limit 5); skeletal muscle: 7.6 nTPM (vital, limit 1); lymph node: 7 nTPM (protected, limit 3); cerebellum: 6.5 nTPM (vital, limit 1); small intestine: 6.3 nTPM (vital, limit 1); duodenum: 6.2 nTPM (vital, limit 1); salivary gland: 6 nTPM (protected, limit 3); pancreas: 5.4 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); adipose tissue: 5.4 nTPM (manageable, limit 5); urinary bladder: 5.2 nTPM (protected, limit 3); esophagus: 5 nTPM (protected, limit 3); pituitary gland: 4.9 nTPM (vital, limit 1); colon: 4.9 nTPM (protected, limit 3); kidney: 4.7 nTPM (vital, limit 1); heart muscle: 4.6 nTPM (vital, limit 1); lung: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 3); liver: 4.2 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); midbrain: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF646,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000167397,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.6609% (minimum 60%, Approved); adrenal gland: 51.6698% (minimum 75%, Missing); amygdala: 72.0569% (minimum 75%, Missing); basal ganglia: 68.5117% (minimum 75%, Missing); bone marrow: 67.1894% (minimum 75%, Missing); cerebellum: 72.8105% (minimum 75%, Missing); cerebral cortex: 73.4344% (minimum 75%, Missing); choroid plexus: 42.3574% (minimum 75%, Missing); colon: 54.2885% (minimum 70%, Missing); duodenum: 72.1970% (minimum 75%, Missing); esophagus: 68.8504% (minimum 70%, Missing); heart muscle: 53.7645% (minimum 70%, Approved); hippocampal formation: 70.3727% (minimum 75%, Missing); hypothalamus: 70.1070% (minimum 75%, Missing); kidney: 48.2878% (minimum 75%, Missing); liver: 20.0685% (minimum 75%, Missing); lung: 59.7639% (minimum 75%, Missing); midbrain: 67.7204% (minimum 75%, Missing); pancreas: 40.6421% (minimum 75%, Missing); parathyroid gland: 69.2356% (minimum 70%, Missing); pituitary gland: 49.7321% (minimum 75%, Missing); salivary gland: 55.3953% (minimum 70%, Missing); skin: 58.6316% (minimum 65%, Missing); small intestine: 58.2331% (minimum 75%, Missing); smooth muscle: 57.7202% (minimum 70%, Approved); spinal cord: 65.5680% (minimum 75%, Missing); spleen: 64.7298% (minimum 65%, Missing); stomach: 56.6057% (minimum 70%, Missing); thyroid gland: 60.0863% (minimum 65%, Missing); urinary bladder: 53.3781% (minimum 70%, Missing)",-0.0636842,-0.166219,-0.549315,0,4,partial,443.7,97.3,96.2,"liver: 443.7 nTPM (vital, limit 1); pancreas: 162.7 nTPM (vital, limit 1); choroid plexus: 151.6 nTPM (vital, limit 1); kidney: 119.3 nTPM (vital, limit 1); pituitary gland: 112.6 nTPM (vital, limit 1); adrenal gland: 104.2 nTPM (vital, limit 1); urinary bladder: 97.3 nTPM (protected, limit 3); adipose tissue: 96.2 nTPM (manageable, limit 10); heart muscle: 95.8 nTPM (vital, limit 2); colon: 93.8 nTPM (protected, limit 3); salivary gland: 89.7 nTPM (protected, limit 3); stomach: 85.4 nTPM (protected, limit 3); smooth muscle: 81.6 nTPM (vital, limit 2); small intestine: 79.9 nTPM (vital, limit 1); skin: 78.6 nTPM (manageable, limit 5); lung: 75 nTPM (vital, limit 1); thyroid gland: 74 nTPM (manageable, limit 5); spleen: 60.7 nTPM (manageable, limit 5); spinal cord: 58.5 nTPM (vital, limit 1); bone marrow: 54.4 nTPM (vital, limit 1); midbrain: 53.1 nTPM (vital, limit 1); basal ganglia: 51.2 nTPM (vital, limit 1); esophagus: 50.4 nTPM (protected, limit 3); parathyroid gland: 49.5 nTPM (protected, limit 3); hypothalamus: 47.5 nTPM (vital, limit 1); hippocampal formation: 46.9 nTPM (vital, limit 1); amygdala: 43.2 nTPM (vital, limit 1); duodenum: 42.9 nTPM (vital, limit 1); cerebellum: 41.6 nTPM (vital, limit 1); cerebral cortex: 40.3 nTPM (vital, limit 1); rectum: 39.7 nTPM (protected, limit 4); lymph node: 35 nTPM (protected, limit 3); thymus: 34 nTPM (manageable, limit 5); skeletal muscle: 33.2 nTPM (vital, limit 2); tongue: 31.1 nTPM (protected, limit 3); retina: 22.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,VKORC1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000167523,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.320228,0.256822,0.142828,0,13,partial,13.3,5.1,8.1,"choroid plexus: 13.3 nTPM (vital, limit 1); kidney: 11.5 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); cerebral cortex: 9 nTPM (vital, limit 6); small intestine: 8.9 nTPM (vital, limit 1); hippocampal formation: 8.3 nTPM (vital, limit 1); amygdala: 7.9 nTPM (vital, limit 1); basal ganglia: 7.2 nTPM (vital, limit 1); retina: 6.5 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 6); midbrain: 5.7 nTPM (vital, limit 1); spinal cord: 5.1 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 3); stomach: 4.9 nTPM (protected, limit 3); duodenum: 4.8 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / enterocytes: Low (Enhanced); duodenum / paneth cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes: Low (Enhanced); small intestine / paneth cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA33,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000167525,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341949,0.29711,0.221284,0,4,partial,8,2.2,9.6,"kidney: 8 nTPM (vital, limit 2); cerebellum: 7.2 nTPM (vital, limit 2); basal ganglia: 5.1 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); choroid plexus: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 2); midbrain: 4.3 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); small intestine: 3.8 nTPM (vital, limit 2); pituitary gland: 2.9 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 2); heart muscle: 2.2 nTPM (vital, limit 2); retina: 1.3 nTPM (vital, limit 1)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PROCA1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000167531,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LALBA,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000167554,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 71.3415% (minimum 75%, Missing); hippocampal formation: 74.0506% (minimum 75%, Missing); hypothalamus: 73.1250% (minimum 75%, Missing); midbrain: 73.1250% (minimum 75%, Missing); retina: 66.1017% (minimum 75%, Missing); spinal cord: 70.4819% (minimum 75%, Missing)",0.0722222,0.173134,-0.0889831,0,2,partial,6,3.9,4.5,"retina: 6 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); basal ganglia: 4.7 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); lung: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF610,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000167562,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.2381% (minimum 75%, Missing); bone marrow: 52.6786% (minimum 75%, Missing); colon: 60.8247% (minimum 70%, Missing); duodenum: 64.8352% (minimum 75%, Missing); esophagus: 68.6047% (minimum 70%, Missing); heart muscle: 68.6047% (minimum 75%, Missing); kidney: 62.7660% (minimum 75%, Missing); lung: 61.4583% (minimum 75%, Missing); lymph node: 51.3043% (minimum 70%, Missing); pancreas: 67.8161% (minimum 75%, Missing); parathyroid gland: 61.4583% (minimum 70%, Missing); pituitary gland: 72.8395% (minimum 75%, Missing); rectum: 55.6604% (minimum 70%, Missing); retina: 64.1304% (minimum 75%, Missing); salivary gland: 65.5556% (minimum 70%, Missing); skeletal muscle: 73.7500% (minimum 75%, Missing); skin: 59.0000% (minimum 65%, Missing); small intestine: 57.2816% (minimum 75%, Missing); smooth muscle: 64.8352% (minimum 75%, Missing); spleen: 55.6604% (minimum 65%, Missing); stomach: 57.2816% (minimum 70%, Missing); thymus: 45.0382% (minimum 65%, Missing); thyroid gland: 50.8621% (minimum 65%, Missing); tongue: 67.0455% (minimum 70%, Missing); urinary bladder: 65.5556% (minimum 70%, Missing)",-0.199618,-0.186957,-0.223214,0,80,unavailable,5.3,5.6,7.2,"thymus: 7.2 nTPM (manageable, limit 5); thyroid gland: 5.7 nTPM (manageable, limit 5); lymph node: 5.6 nTPM (protected, limit 3); bone marrow: 5.3 nTPM (vital, limit 1); rectum: 4.7 nTPM (protected, limit 3); stomach: 4.4 nTPM (protected, limit 3); small intestine: 4.4 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); parathyroid gland: 3.7 nTPM (protected, limit 3); lung: 3.7 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 3); urinary bladder: 3.1 nTPM (protected, limit 3); pancreas: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF701,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000167612,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"parathyroid gland: 20.0000% (minimum 55%, Enhanced); retina: 2.7322% (minimum 75%, Missing)",0.35,-0.35,-0.722678,0,3,partial,17.8,2,0,"retina: 17.8 nTPM (vital, limit 1)",retina / photoreceptor cells: High (Enhanced),59,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ANKRD33,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000167632,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.7065% (minimum 65%, Missing); adrenal gland: 47.5806% (minimum 75%, Missing); amygdala: 50.6438% (minimum 75%, Missing); basal ganglia: 46.4567% (minimum 75%, Missing); bone marrow: 51.7544% (minimum 75%, Missing); cerebellum: 42.7536% (minimum 75%, Missing); cerebral cortex: 38.6885% (minimum 75%, Missing); choroid plexus: 49.3724% (minimum 75%, Missing); colon: 52.2124% (minimum 70%, Missing); duodenum: 60.2041% (minimum 75%, Missing); esophagus: 49.5798% (minimum 70%, Missing); heart muscle: 44.6970% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 50.4274% (minimum 75%, Missing); kidney: 46.8254% (minimum 75%, Missing); liver: 51.0823% (minimum 75%, Missing); lung: 56.1905% (minimum 75%, Missing); lymph node: 60.2041% (minimum 70%, Missing); midbrain: 47.5806% (minimum 75%, Missing); pancreas: 50.6438% (minimum 75%, Missing); parathyroid gland: 30.8094% (minimum 70%, Missing); pituitary gland: 36.8750% (minimum 75%, Missing); rectum: 67.0455% (minimum 70%, Missing); retina: 46.0938% (minimum 75%, Missing); salivary gland: 51.0823% (minimum 70%, Missing); skeletal muscle: 26.6968% (minimum 75%, Missing); skin: 51.7544% (minimum 65%, Missing); small intestine: 52.9148% (minimum 75%, Missing); smooth muscle: 63.1016% (minimum 75%, Missing); spinal cord: 46.4567% (minimum 75%, Missing); spleen: 51.7544% (minimum 65%, Missing); stomach: 49.3724% (minimum 70%, Missing); thymus: 51.7544% (minimum 65%, Missing); thyroid gland: 48.5597% (minimum 65%, Missing); tongue: 40.9722% (minimum 70%, Missing); urinary bladder: 52.2124% (minimum 70%, Missing)",-0.164403,-0.391906,-0.483032,0,80,unavailable,32.4,26.5,12.5,"skeletal muscle: 32.4 nTPM (vital, limit 1); parathyroid gland: 26.5 nTPM (protected, limit 3); pituitary gland: 20.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); tongue: 17 nTPM (protected, limit 3); cerebellum: 15.8 nTPM (vital, limit 1); heart muscle: 14.6 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); spinal cord: 13.6 nTPM (vital, limit 1); basal ganglia: 13.6 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); midbrain: 13 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); thyroid gland: 12.5 nTPM (manageable, limit 5); choroid plexus: 12.1 nTPM (vital, limit 1); stomach: 12.1 nTPM (protected, limit 3); esophagus: 12 nTPM (protected, limit 3); hippocampal formation: 11.8 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); pancreas: 11.5 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); liver: 11.3 nTPM (vital, limit 1); salivary gland: 11.3 nTPM (protected, limit 3); thymus: 11 nTPM (manageable, limit 5); spleen: 11 nTPM (manageable, limit 5); bone marrow: 11 nTPM (vital, limit 1); skin: 11 nTPM (manageable, limit 5); urinary bladder: 10.8 nTPM (protected, limit 3); colon: 10.8 nTPM (protected, limit 3); small intestine: 10.5 nTPM (vital, limit 1); lung: 9.2 nTPM (vital, limit 1); adipose tissue: 8.3 nTPM (manageable, limit 5); lymph node: 7.8 nTPM (protected, limit 3); duodenum: 7.8 nTPM (vital, limit 1); smooth muscle: 6.9 nTPM (vital, limit 1); rectum: 5.8 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRAPPC9,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000167634,True,compatible,,True,True,True,,0.213636,0.274359,0.2,0,80,unavailable,0.2,0.1,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NLRP7,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000167791,False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,7.1,0,0.8,"retina: 7.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,CABP2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000167981,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.8571% (minimum 70%, Approved); bone marrow: 67.8571% (minimum 70%, Approved); cerebral cortex: 64.4068% (minimum 75%, Missing); kidney: 74.5098% (minimum 75%, Missing); liver: 69.0909% (minimum 70%, Approved); lung: 62.2951% (minimum 70%, Approved); lymph node: 64.4068% (minimum 65%, Approved); pituitary gland: 74.5098% (minimum 75%, Missing); retina: 62.2951% (minimum 75%, Missing)",0.0666667,-0.0059322,-0.127049,0,5,partial,2.3,2.1,1.9,"lung: 2.3 nTPM (vital, limit 2); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); kidney / cells in tubules: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF597,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000167985,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.1056% (minimum 65%, Missing); adrenal gland: 48.6409% (minimum 75%, Missing); amygdala: 59.3368% (minimum 75%, Missing); basal ganglia: 56.7613% (minimum 75%, Missing); bone marrow: 42.9836% (minimum 75%, Missing); cerebellum: 68.0000% (minimum 75%, Missing); cerebral cortex: 58.2192% (minimum 75%, Missing); choroid plexus: 47.6190% (minimum 75%, Missing); colon: 56.3847% (minimum 70%, Missing); duodenum: 58.6207% (minimum 75%, Missing); esophagus: 54.8387% (minimum 70%, Missing); heart muscle: 46.5116% (minimum 75%, Missing); hippocampal formation: 62.8466% (minimum 75%, Missing); hypothalamus: 53.8827% (minimum 75%, Missing); kidney: 48.9209% (minimum 75%, Missing); liver: 42.8752% (minimum 75%, Missing); lung: 59.6491% (minimum 75%, Missing); lymph node: 46.6392% (minimum 70%, Missing); midbrain: 57.4324% (minimum 75%, Missing); pancreas: 59.4406% (minimum 75%, Missing); parathyroid gland: 51.6717% (minimum 70%, Missing); pituitary gland: 46.0081% (minimum 75%, Missing); rectum: 54.6624% (minimum 70%, Missing); retina: 59.9647% (minimum 75%, Missing); salivary gland: 57.1429% (minimum 70%, Missing); skeletal muscle: 47.4860% (minimum 75%, Missing); skin: 57.1429% (minimum 65%, Missing); small intestine: 56.3847% (minimum 75%, Missing); smooth muscle: 56.7613% (minimum 75%, Missing); spinal cord: 61.7060% (minimum 75%, Missing); spleen: 50.0736% (minimum 65%, Missing); stomach: 55.9211% (minimum 70%, Missing); thymus: 47.8873% (minimum 65%, Missing); thyroid gland: 55.0162% (minimum 65%, Missing); tongue: 44.0986% (minimum 70%, Missing); urinary bladder: 51.8293% (minimum 70%, Missing)",-0.171127,-0.259014,-0.321248,0,4,partial,45.3,43.1,37,"liver: 45.3 nTPM (vital, limit 1); bone marrow: 45.1 nTPM (vital, limit 1); tongue: 43.1 nTPM (protected, limit 3); pituitary gland: 39.9 nTPM (vital, limit 1); heart muscle: 39.1 nTPM (vital, limit 1); lymph node: 38.9 nTPM (protected, limit 3); skeletal muscle: 37.6 nTPM (vital, limit 1); choroid plexus: 37.4 nTPM (vital, limit 1); thymus: 37 nTPM (manageable, limit 5); adrenal gland: 35.9 nTPM (vital, limit 1); kidney: 35.5 nTPM (vital, limit 1); spleen: 33.9 nTPM (manageable, limit 5); parathyroid gland: 31.8 nTPM (protected, limit 3); urinary bladder: 31.6 nTPM (protected, limit 3); hypothalamus: 29.1 nTPM (vital, limit 1); rectum: 28.2 nTPM (protected, limit 3); esophagus: 28 nTPM (protected, limit 3); thyroid gland: 27.8 nTPM (manageable, limit 5); stomach: 26.8 nTPM (protected, limit 3); adipose tissue: 26.6 nTPM (manageable, limit 5); small intestine: 26.3 nTPM (vital, limit 1); colon: 26.3 nTPM (protected, limit 3); smooth muscle: 25.9 nTPM (vital, limit 1); basal ganglia: 25.9 nTPM (vital, limit 1); salivary gland: 25.5 nTPM (protected, limit 3); skin: 25.5 nTPM (manageable, limit 5); midbrain: 25.2 nTPM (vital, limit 1); cerebral cortex: 24.4 nTPM (vital, limit 1); duodenum: 24 nTPM (vital, limit 1); amygdala: 23.3 nTPM (vital, limit 1); pancreas: 23.2 nTPM (vital, limit 1); lung: 23 nTPM (vital, limit 1); retina: 22.7 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); hippocampal formation: 20.1 nTPM (vital, limit 1); cerebellum: 16 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Medium (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Low (Supported); lymph node / non-germinal center cells: Low (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: High (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SDHAF2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000168026,True,compatible,,True,True,True,,0.338938,0.293333,0.230263,0,3,partial,1.2,0.8,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TTC21A,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,False,gained,selectivity_revised
ENSG00000168038,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 72.9904% (minimum 75%, Missing); heart muscle: 73.2258% (minimum 75%, Missing)",0.178467,0.0467105,-0.0200965,0,2,partial,8.4,7.7,4.7,"bone marrow: 8.4 nTPM (vital, limit 1); heart muscle: 8.3 nTPM (vital, limit 1); parathyroid gland: 7.7 nTPM (protected, limit 3); choroid plexus: 7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); lung: 3.4 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ULK4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000168061,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 73.5955% (minimum 75%, Missing); choroid plexus: 65.8291% (minimum 75%, Missing); skeletal muscle: 59.5455% (minimum 75%, Missing)",0.005,0.0891566,-0.154545,0,7,partial,8.9,3.5,6.9,"skeletal muscle: 8.9 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); choroid plexus: 6.8 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); colon: 3.5 nTPM (protected, limit 3); adrenal gland: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SAC3D1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000168070,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.297826,0.239655,0.193723,0,80,unavailable,1.3,1.4,1.2,"kidney: 1.3 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAJIN,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000168078,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.104425,0.145105,0.248536,0,3,partial,9,12.5,22.2,"thymus: 22.2 nTPM (manageable, limit 5); lymph node: 12.5 nTPM (protected, limit 3); bone marrow: 9 nTPM (vital, limit 6); duodenum: 8.1 nTPM (vital, limit 6); small intestine: 7.9 nTPM (vital, limit 6)",lymph node / germinal center cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PBK,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000168116,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 66.4234% (minimum 70%, Approved); bone marrow: 52.0000% (minimum 70%, Approved); cerebellum: 67.4074% (minimum 70%, Approved); cerebral cortex: 60.6667% (minimum 75%, Missing); heart muscle: 72.8000% (minimum 75%, Missing); hypothalamus: 74.5902% (minimum 75%, Missing); kidney: 72.2222% (minimum 75%, Missing); liver: 65.4676% (minimum 70%, Approved); parathyroid gland: 64.0845% (minimum 65%, Approved); pituitary gland: 71.6535% (minimum 75%, Missing); retina: 70.5426% (minimum 75%, Missing); smooth muscle: 68.4211% (minimum 75%, Missing); thymus: 61.4865% (minimum 65%, Missing); urinary bladder: 66.4234% (minimum 70%, Missing)",-0.0351351,-0.0357664,-0.18,0,4,partial,8.4,5.1,5.7,"bone marrow: 8.4 nTPM (vital, limit 2); cerebral cortex: 5.9 nTPM (vital, limit 1); thymus: 5.7 nTPM (manageable, limit 5); parathyroid gland: 5.1 nTPM (protected, limit 4); liver: 4.8 nTPM (vital, limit 2); adrenal gland: 4.6 nTPM (vital, limit 2); urinary bladder: 4.6 nTPM (protected, limit 3); lymph node: 4.5 nTPM (protected, limit 4); cerebellum: 4.4 nTPM (vital, limit 2); smooth muscle: 4.2 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); kidney: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 3); esophagus: 3.2 nTPM (protected, limit 3); hypothalamus: 3.1 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 2); small intestine: 2.4 nTPM (vital, limit 2); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KIAA1586,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000168148,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,,0.35,0.267742,0.1875,0,6,partial,0.2,0.1,0,,adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / cells in basal layer: High (Approved); skin 1 / cells in granular layer: High (Approved); skin 1 / cells in spinous layer: High (Approved); skin 1 / endothelial cells: High (Approved); skin 1 / fibrohistiocytic cells: High (Approved); skin 1 / langerhans cells: High (Approved); skin 1 / lymphocytes: High (Approved); skin 1 / vascular mural cells: High (Approved); skin 2 / cells in basal layer: High (Approved); skin 2 / cells in granular layer: High (Approved); skin 2 / cells in spinous layer: High (Approved); skin 2 / endothelial cells: High (Approved); skin 2 / fibrohistiocytic cells: High (Approved); skin 2 / langerhans cells: High (Approved); skin 2 / lymphocytes: High (Approved); skin 2 / vascular mural cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / vascular mural cells; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,H3-4,current_adaptive,False,False,False,False,10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000168152,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 74.7126% (minimum 75%, Missing); basal ganglia: 74.7126% (minimum 75%, Missing); heart muscle: 71.4286% (minimum 75%, Missing); hippocampal formation: 71.4286% (minimum 75%, Missing); kidney: 69.1489% (minimum 75%, Missing); liver: 67.7083% (minimum 75%, Missing); midbrain: 69.8925% (minimum 75%, Missing); pancreas: 73.0337% (minimum 75%, Missing); parathyroid gland: 67.7083% (minimum 70%, Missing); pituitary gland: 71.4286% (minimum 75%, Missing); retina: 60.7477% (minimum 75%, Missing); skeletal muscle: 56.5217% (minimum 75%, Missing); spinal cord: 65.0000% (minimum 75%, Missing); thyroid gland: 61.9048% (minimum 65%, Missing); tongue: 49.6183% (minimum 70%, Missing)",-0.0309524,-0.203817,-0.184783,0,2,partial,5,6.6,4,"tongue: 6.6 nTPM (protected, limit 3); skeletal muscle: 5 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,THAP9,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000168263,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 1.6491% (minimum 75%, Missing)",0.35,0.3,-0.733509,0,1,partial,280.3,0.1,0.1,"retina: 280.3 nTPM (vital, limit 1)",retina / photoreceptor cells: Medium (Enhanced),61,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KCNV2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000168267,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 2.0329% (minimum 75%, Missing); stomach: 52.5000% (minimum 70%, Missing)",0.35,-0.175,-0.729671,0,80,unavailable,101.2,1.9,0,"pancreas: 101.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PTF1A,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000168314,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 2.8711% (minimum 75%, Missing); basal ganglia: 4.0091% (minimum 75%, Missing); cerebellum: 20.3065% (minimum 60%, Enhanced); cerebral cortex: 4.9165% (minimum 75%, Missing); choroid plexus: 9.3805% (minimum 75%, Missing); hippocampal formation: 1.9835% (minimum 75%, Missing); hypothalamus: 2.8836% (minimum 75%, Missing); midbrain: 1.2206% (minimum 75%, Missing); spinal cord: 0.4854% (minimum 75%, Missing)",0.35,0.147368,-0.745146,0,2,partial,1086.6,2.3,0.2,"spinal cord: 1086.6 nTPM (vital, limit 1); midbrain: 428.9 nTPM (vital, limit 1); hippocampal formation: 261.9 nTPM (vital, limit 1); amygdala: 179.3 nTPM (vital, limit 1); hypothalamus: 178.5 nTPM (vital, limit 1); basal ganglia: 126.9 nTPM (vital, limit 1); cerebral cortex: 102.5 nTPM (vital, limit 1); choroid plexus: 51.2 nTPM (vital, limit 1); cerebellum: 20.8 nTPM (vital, limit 6)",cerebral cortex / neuropil: Medium (Enhanced),53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MOBP,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000168438,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.0281% (minimum 65%, Missing); adrenal gland: 50.0000% (minimum 75%, Missing); amygdala: 65.4378% (minimum 75%, Missing); basal ganglia: 50.0000% (minimum 75%, Missing); bone marrow: 27.3603% (minimum 75%, Missing); cerebellum: 62.2807% (minimum 75%, Missing); cerebral cortex: 52.3985% (minimum 75%, Missing); choroid plexus: 68.2692% (minimum 75%, Missing); colon: 57.0281% (minimum 70%, Missing); duodenum: 57.0281% (minimum 75%, Missing); esophagus: 57.7236% (minimum 70%, Missing); heart muscle: 58.4362% (minimum 75%, Missing); hippocampal formation: 57.2581% (minimum 75%, Missing); hypothalamus: 68.5990% (minimum 75%, Missing); kidney: 47.4916% (minimum 75%, Missing); liver: 46.5574% (minimum 75%, Missing); lung: 57.2581% (minimum 75%, Missing); lymph node: 42.6426% (minimum 70%, Missing); midbrain: 70.6468% (minimum 75%, Missing); pancreas: 54.1985% (minimum 75%, Missing); parathyroid gland: 51.2635% (minimum 70%, Missing); pituitary gland: 60.6838% (minimum 75%, Missing); rectum: 54.8263% (minimum 70%, Missing); retina: 49.8246% (minimum 75%, Missing); salivary gland: 57.0281% (minimum 70%, Missing); skeletal muscle: 55.9055% (minimum 75%, Missing); skin: 57.9592% (minimum 65%, Missing); small intestine: 57.0281% (minimum 75%, Missing); smooth muscle: 59.1667% (minimum 75%, Missing); spinal cord: 67.6190% (minimum 75%, Missing); spleen: 47.6510% (minimum 65%, Missing); stomach: 56.1265% (minimum 70%, Missing); thymus: 43.9628% (minimum 65%, Missing); thyroid gland: 47.9730% (minimum 65%, Missing); tongue: 56.1265% (minimum 70%, Missing); urinary bladder: 53.7879% (minimum 70%, Missing)",-0.210372,-0.273574,-0.476397,0,80,unavailable,37.7,19.1,18.1,"bone marrow: 37.7 nTPM (vital, limit 1); lymph node: 19.1 nTPM (protected, limit 3); thymus: 18.1 nTPM (manageable, limit 5); liver: 16.3 nTPM (vital, limit 1); kidney: 15.7 nTPM (vital, limit 1); spleen: 15.6 nTPM (manageable, limit 5); thyroid gland: 15.4 nTPM (manageable, limit 5); retina: 14.3 nTPM (vital, limit 1); adrenal gland: 14.2 nTPM (vital, limit 1); basal ganglia: 14.2 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 3); cerebral cortex: 12.9 nTPM (vital, limit 1); urinary bladder: 12.2 nTPM (protected, limit 3); pancreas: 12 nTPM (vital, limit 1); rectum: 11.7 nTPM (protected, limit 3); skeletal muscle: 11.2 nTPM (vital, limit 1); stomach: 11.1 nTPM (protected, limit 3); tongue: 11.1 nTPM (protected, limit 3); salivary gland: 10.7 nTPM (protected, limit 3); small intestine: 10.7 nTPM (vital, limit 1); adipose tissue: 10.7 nTPM (manageable, limit 5); duodenum: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 3); lung: 10.6 nTPM (vital, limit 1); hippocampal formation: 10.6 nTPM (vital, limit 1); esophagus: 10.4 nTPM (protected, limit 3); skin: 10.3 nTPM (manageable, limit 5); heart muscle: 10.1 nTPM (vital, limit 1); smooth muscle: 9.8 nTPM (vital, limit 1); pituitary gland: 9.2 nTPM (vital, limit 1); cerebellum: 8.6 nTPM (vital, limit 1); amygdala: 7.5 nTPM (vital, limit 1); spinal cord: 6.8 nTPM (vital, limit 1); choroid plexus: 6.6 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CDC40,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000168454,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.298995,0.248995,0,2,partial,0.3,0.1,0.1,,bronchus / respiratory epithelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / macrophages: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder / glandular cells; salivary gland; skin 1 / keratinocytes; skin 1 / melanocytes,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TXNDC2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000168491,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.278298,0.241804,0.0157729,0,80,unavailable,29.7,6,7.5,"pancreas: 29.7 nTPM (vital, limit 1); retina: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); salivary gland: 6 nTPM (protected, limit 3); pituitary gland: 2.8 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC110,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000168515,True,compatible,,True,True,True,,0.0166667,0.223077,0.173077,0,80,unavailable,0.1,0.1,0.6,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SCGB1D1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000168589,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335714,0.280462,0.0468243,0,80,unavailable,56.3,4.4,3.2,"choroid plexus: 56.3 nTPM (vital, limit 1); hippocampal formation: 11.5 nTPM (vital, limit 1); hypothalamus: 11.4 nTPM (vital, limit 1); basal ganglia: 11.3 nTPM (vital, limit 1); amygdala: 8.8 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); spinal cord: 5.6 nTPM (vital, limit 1); parathyroid gland: 4.4 nTPM (protected, limit 3); pituitary gland: 4.2 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DYNLRB2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000168594,True,compatible,,True,True,True,,0.35,0.2975,0.245012,0,80,unavailable,0.2,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ADAM29,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000168619,True,compatible,,True,True,True,,0.35,0.3,0.238889,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ADAM18,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000168658,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.326589,0.296587,0.0124021,0,5,partial,9.1,0.1,0.7,"choroid plexus: 9.1 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved),62,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,VWA3B,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000168676,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.302381,0.281595,0.156516,0,80,unavailable,3.3,0.6,1.6,"bone marrow: 3.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KCTD19,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000168702,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 42.3077% (minimum 65%, Missing); adrenal gland: 62.8571% (minimum 75%, Missing); amygdala: 20.7547% (minimum 75%, Missing); basal ganglia: 21.5686% (minimum 75%, Missing); cerebellum: 28.9474% (minimum 75%, Missing); cerebral cortex: 18.4874% (minimum 75%, Missing); choroid plexus: 68.7500% (minimum 75%, Missing); hippocampal formation: 24.7191% (minimum 75%, Missing); hypothalamus: 25.0000% (minimum 75%, Missing); midbrain: 22.2222% (minimum 75%, Missing); pituitary gland: 53.6585% (minimum 75%, Missing); retina: 46.8085% (minimum 75%, Missing); skeletal muscle: 33.8462% (minimum 75%, Missing); spinal cord: 31.8841% (minimum 75%, Missing); thyroid gland: 28.5714% (minimum 65%, Missing); tongue: 39.2857% (minimum 70%, Missing)",-0.364286,-0.307143,-0.565126,0,1,partial,9.7,3.4,5.5,"cerebral cortex: 9.7 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); basal ganglia: 8 nTPM (vital, limit 1); midbrain: 7.7 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (manageable, limit 5); cerebellum: 5.4 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); tongue: 3.4 nTPM (protected, limit 3); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); thyroid gland / glandular cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRP1B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000168757,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TSPY2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000168904,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 70.2290% (minimum 75%, Missing); duodenum: 62.7273% (minimum 75%, Missing); heart muscle: 74.5946% (minimum 75%, Missing); kidney: 59.6112% (minimum 75%, Missing); liver: 37.7049% (minimum 75%, Missing); pancreas: 59.3548% (minimum 75%, Missing); skeletal muscle: 60.9272% (minimum 75%, Missing); small intestine: 63.3028% (minimum 75%, Missing); thymus: 55.6452% (minimum 65%, Missing); tongue: 61.0619% (minimum 70%, Missing)",-0.0935484,-0.0893805,-0.372951,0,4,partial,45.6,17.6,22,"liver: 45.6 nTPM (vital, limit 1); thymus: 22 nTPM (manageable, limit 5); pancreas: 18.9 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); skeletal muscle: 17.7 nTPM (vital, limit 1); tongue: 17.6 nTPM (protected, limit 3); duodenum: 16.4 nTPM (vital, limit 1); small intestine: 16 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); skin: 10.1 nTPM (manageable, limit 5); rectum: 9.4 nTPM (protected, limit 3); heart muscle: 9.4 nTPM (vital, limit 1); esophagus: 9.3 nTPM (protected, limit 3); parathyroid gland: 9.1 nTPM (protected, limit 3); bone marrow: 8.5 nTPM (vital, limit 1); stomach: 7.9 nTPM (protected, limit 3); adipose tissue: 7.8 nTPM (manageable, limit 5); colon: 7.7 nTPM (protected, limit 3); smooth muscle: 7.6 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); lymph node: 6.7 nTPM (protected, limit 3); retina: 6.6 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (manageable, limit 5); urinary bladder: 6.3 nTPM (protected, limit 3); salivary gland: 6 nTPM (protected, limit 3); cerebellum: 5.5 nTPM (vital, limit 1); lung: 5.1 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); hypothalamus: 4.3 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); amygdala: 4.1 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); basal ganglia: 3.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRRC28,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000168930,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRIM49,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000168944,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.6168% (minimum 65%, Missing); adrenal gland: 66.3366% (minimum 75%, Missing); amygdala: 74.8603% (minimum 75%, Missing); basal ganglia: 73.2240% (minimum 75%, Missing); cerebellum: 54.4715% (minimum 75%, Missing); colon: 66.0099% (minimum 70%, Missing); duodenum: 74.0331% (minimum 75%, Missing); heart muscle: 69.0722% (minimum 75%, Missing); hippocampal formation: 72.0430% (minimum 75%, Missing); hypothalamus: 68.7179% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 63.5071% (minimum 75%, Missing); lung: 65.3659% (minimum 75%, Missing); lymph node: 59.5556% (minimum 70%, Missing); midbrain: 72.0430% (minimum 75%, Missing); pancreas: 68.7179% (minimum 75%, Missing); parathyroid gland: 64.7343% (minimum 70%, Missing); pituitary gland: 67.6768% (minimum 75%, Missing); retina: 54.4715% (minimum 75%, Missing); small intestine: 65.3659% (minimum 75%, Missing); smooth muscle: 63.5071% (minimum 75%, Missing); spinal cord: 66.6667% (minimum 75%, Missing); spleen: 60.3604% (minimum 65%, Missing); thymus: 49.6296% (minimum 65%, Missing); thyroid gland: 62.6168% (minimum 65%, Missing); tongue: 69.4301% (minimum 70%, Missing); urinary bladder: 67.6768% (minimum 70%, Missing)",-0.153704,-0.104444,-0.205285,0,80,unavailable,11.2,9.1,13.6,"thymus: 13.6 nTPM (manageable, limit 5); retina: 11.2 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); lymph node: 9.1 nTPM (protected, limit 3); spleen: 8.8 nTPM (manageable, limit 5); thyroid gland: 8 nTPM (manageable, limit 5); adipose tissue: 8 nTPM (manageable, limit 5); smooth muscle: 7.7 nTPM (vital, limit 1); liver: 7.7 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 3); small intestine: 7.1 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); colon: 6.9 nTPM (protected, limit 3); adrenal gland: 6.8 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); kidney: 6.7 nTPM (vital, limit 1); pituitary gland: 6.4 nTPM (vital, limit 1); urinary bladder: 6.4 nTPM (protected, limit 3); pancreas: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); tongue: 5.9 nTPM (protected, limit 3); midbrain: 5.2 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); salivary gland: 5 nTPM (protected, limit 3); rectum: 5 nTPM (protected, limit 3); stomach: 4.9 nTPM (protected, limit 3); basal ganglia: 4.9 nTPM (vital, limit 1); duodenum: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); esophagus: 4.3 nTPM (protected, limit 3); cerebral cortex: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CEP120,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000169059,True,compatible,,True,True,True,,0.35,0.3,0.242551,0,1,partial,0.4,0.1,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,VCX3A,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000169064,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 72.4066% (minimum 75%, Missing)",0.347143,0.3,-0.0259336,0,4,partial,13.3,0.2,0.1,"choroid plexus: 13.3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZBBX,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000169126,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.3375,0.292462,0.0850951,0,3,partial,7.8,1,0.5,"choroid plexus: 7.8 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ODAD2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000169154,True,compatible,,True,True,True,,0.35,0.292754,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GOT1L1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000169169,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 60.0000% (minimum 70%, Approved); amygdala: 30.1158% (minimum 75%, Missing); basal ganglia: 24.8408% (minimum 75%, Missing); cerebellum: 22.5434% (minimum 75%, Missing); cerebral cortex: 23.6364% (minimum 75%, Missing); choroid plexus: 21.4876% (minimum 75%, Missing); heart muscle: 67.8261% (minimum 70%, Approved); hippocampal formation: 27.3684% (minimum 75%, Missing); hypothalamus: 27.6596% (minimum 75%, Missing); midbrain: 39.1960% (minimum 75%, Missing); pituitary gland: 22.0339% (minimum 75%, Missing); retina: 39.1960% (minimum 75%, Missing); smooth muscle: 63.9344% (minimum 75%, Missing); spinal cord: 40.0000% (minimum 75%, Missing)",0.0190476,0.1,-0.535124,0,2,partial,28.5,2.6,4.8,"choroid plexus: 28.5 nTPM (vital, limit 1); pituitary gland: 27.6 nTPM (vital, limit 1); cerebellum: 26.8 nTPM (vital, limit 1); cerebral cortex: 25.2 nTPM (vital, limit 1); basal ganglia: 23.6 nTPM (vital, limit 1); hippocampal formation: 20.7 nTPM (vital, limit 1); hypothalamus: 20.4 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); midbrain: 12.1 nTPM (vital, limit 1); retina: 12.1 nTPM (vital, limit 1); spinal cord: 11.7 nTPM (vital, limit 1); adrenal gland: 5.2 nTPM (vital, limit 2); smooth muscle: 4.4 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 2); kidney: 1.6 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); salivary gland / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CPT1C,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000169194,True,compatible,,True,True,True,,0.333333,0.291597,0.241597,0,80,unavailable,0.2,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IL13,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000169214,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR6F1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000169248,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 35.7143% (minimum 75%, Missing); basal ganglia: 72.4638% (minimum 75%, Missing); cerebral cortex: 48.0769% (minimum 75%, Uncertain); hippocampal formation: 61.7284% (minimum 75%, Missing); hypothalamus: 58.1395% (minimum 75%, Missing); liver: 68.4932% (minimum 75%, Uncertain); lung: 46.2963% (minimum 75%, Uncertain); lymph node: 30.1205% (minimum 70%, Uncertain); midbrain: 64.9351% (minimum 75%, Missing); pancreas: 36.7647% (minimum 75%, Uncertain); rectum: 54.3478% (minimum 70%, Uncertain); salivary gland: 62.5000% (minimum 70%, Uncertain); spinal cord: 48.0769% (minimum 75%, Missing); spleen: 47.1698% (minimum 65%, Uncertain); stomach: 45.0450% (minimum 70%, Uncertain); thymus: 44.6429% (minimum 65%, Missing); urinary bladder: 52.6316% (minimum 70%, Uncertain)",-0.203571,-0.398795,-0.392857,0,0,routine_complete,9,11.6,6.2,"lymph node: 11.6 nTPM (protected, limit 3); amygdala: 9 nTPM (vital, limit 1); pancreas: 8.6 nTPM (vital, limit 1); thymus: 6.2 nTPM (manageable, limit 5); stomach: 6.1 nTPM (protected, limit 3); lung: 5.8 nTPM (vital, limit 1); spleen: 5.6 nTPM (manageable, limit 5); cerebral cortex: 5.4 nTPM (vital, limit 1); spinal cord: 5.4 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 3); rectum: 4.2 nTPM (protected, limit 3); hypothalamus: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CXCL11,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000169340,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"stomach: 13.1004% (minimum 70%, Missing)",0.35,-0.568996,0.25,0,1,partial,0.4,119.4,0.1,"stomach: 119.4 nTPM (protected, limit 3)",stomach 2 / glandular cells: Low (Approved),55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PDILT,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000169393,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.224473,0,1,partial,72.3,0,0,"retina: 72.3 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ELSPBP1,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000169402,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.09,0,4,partial,3.6,1.2,0.3,"choroid plexus: 3.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),58,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RSPH10B2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000169495,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343837,0.293837,0.236239,0,5,partial,6.8,2.2,1,"bone marrow: 6.8 nTPM (vital, limit 6)",,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HTRA4,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000169551,True,compatible,,True,True,True,,0.323684,0.3,0.175,0,80,unavailable,0.3,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT55,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000169570,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 60.4938% (minimum 75%, Missing); cerebellum: 63.6364% (minimum 70%, Approved); cerebral cortex: 66.2162% (minimum 70%, Approved); colon: 61.2500% (minimum 70%, Missing); duodenum: 62.0253% (minimum 75%, Missing); esophagus: 54.4444% (minimum 70%, Missing); heart muscle: 43.7500% (minimum 75%, Missing); kidney: 44.1441% (minimum 75%, Missing); liver: 53.2609% (minimum 70%, Approved); lung: 68.0556% (minimum 70%, Approved); pancreas: 62.8205% (minimum 75%, Missing); parathyroid gland: 52.1277% (minimum 65%, Approved); rectum: 60.4938% (minimum 70%, Missing); retina: 59.7561% (minimum 75%, Missing); salivary gland: 61.2500% (minimum 70%, Missing); skeletal muscle: 32.8859% (minimum 70%, Approved); skin: 60.4938% (minimum 65%, Missing); small intestine: 65.3333% (minimum 75%, Missing); smooth muscle: 62.0253% (minimum 70%, Approved); spinal cord: 72.0588% (minimum 75%, Missing); spleen: 62.8205% (minimum 65%, Missing); stomach: 65.3333% (minimum 70%, Missing); thyroid gland: 36.0294% (minimum 60%, Approved); tongue: 44.5455% (minimum 70%, Missing); urinary bladder: 63.6364% (minimum 70%, Missing)",-0.239706,-0.254545,-0.371141,0,5,partial,10,6.1,8.7,"skeletal muscle: 10 nTPM (vital, limit 2); heart muscle: 6.3 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 3); parathyroid gland: 4.5 nTPM (protected, limit 4); liver: 4.3 nTPM (vital, limit 2); esophagus: 4.1 nTPM (protected, limit 3); retina: 3.3 nTPM (vital, limit 1); adrenal gland: 3.2 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 3); salivary gland: 3.1 nTPM (protected, limit 3); colon: 3.1 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); smooth muscle: 3 nTPM (vital, limit 2); pancreas: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 2); small intestine: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 2); lung: 2.3 nTPM (vital, limit 2); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / ciliated cells (cell body): Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DTWD2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000169575,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 0.3390% (minimum 75%, Missing); lymph node: 16.6667% (minimum 65%, Approved); small intestine: 50.0000% (minimum 70%, Approved); thymus: 8.3333% (minimum 65%, Missing)",-0.566667,-0.483333,-0.74661,0,1,partial,29.4,0.5,1.1,"bone marrow: 29.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,VPREB1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000169594,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.6598% (minimum 65%, Missing); esophagus: 66.7575% (minimum 70%, Missing)",-0.0234015,-0.0324251,0.199612,0,80,unavailable,1.3,12.2,14.6,"adipose tissue: 14.6 nTPM (manageable, limit 5); esophagus: 12.2 nTPM (protected, limit 3); skin: 9 nTPM (manageable, limit 5); heart muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BNC1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000169607,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 25.2874% (minimum 75%, Missing); duodenum: 74.5763% (minimum 75%, Missing); esophagus: 65.6716% (minimum 70%, Missing); lymph node: 47.3118% (minimum 70%, Missing); rectum: 67.6923% (minimum 70%, Missing); thymus: 27.3292% (minimum 65%, Missing)",-0.376708,-0.226882,-0.497126,0,3,partial,13,4.9,11.7,"bone marrow: 13 nTPM (vital, limit 1); thymus: 11.7 nTPM (manageable, limit 5); lymph node: 4.9 nTPM (protected, limit 3); duodenum: 1.5 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CKAP2L,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000169621,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.6207% (minimum 65%, Uncertain); adrenal gland: 65.3846% (minimum 75%, Uncertain); bone marrow: 70.8333% (minimum 75%, Uncertain); colon: 62.9630% (minimum 70%, Uncertain); duodenum: 73.9130% (minimum 75%, Uncertain); esophagus: 54.8387% (minimum 70%, Uncertain); heart muscle: 68.0000% (minimum 75%, Uncertain); kidney: 65.3846% (minimum 75%, Uncertain); liver: 53.1250% (minimum 75%, Uncertain); lung: 65.3846% (minimum 75%, Uncertain); lymph node: 58.6207% (minimum 70%, Uncertain); pancreas: 73.9130% (minimum 75%, Uncertain); parathyroid gland: 68.0000% (minimum 70%, Uncertain); rectum: 68.0000% (minimum 70%, Uncertain); salivary gland: 60.7143% (minimum 70%, Uncertain); skeletal muscle: 62.9630% (minimum 75%, Uncertain); skin: 42.5000% (minimum 65%, Uncertain); smooth muscle: 60.7143% (minimum 75%, Uncertain); thyroid gland: 60.7143% (minimum 65%, Uncertain); tongue: 58.6207% (minimum 70%, Missing); urinary bladder: 62.9630% (minimum 70%, Uncertain)",-0.225,-0.151613,-0.21875,0,0,routine_complete,1.5,1.4,2.3,"liver: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,APLF,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000169679,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 71.5328% (minimum 75%, Missing); lymph node: 65.3333% (minimum 70%, Missing); thymus: 52.3132% (minimum 65%, Missing)",-0.126868,-0.0466667,-0.0346715,0,80,unavailable,11.7,15.6,26.8,"thymus: 26.8 nTPM (manageable, limit 5); lymph node: 15.6 nTPM (protected, limit 3); bone marrow: 11.7 nTPM (vital, limit 1); rectum: 5.5 nTPM (protected, limit 3); spleen: 5.5 nTPM (manageable, limit 5); esophagus: 4.5 nTPM (protected, limit 3); colon: 4.2 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BUB1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000169684,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 61.2245% (minimum 70%, Approved); choroid plexus: 73.1707% (minimum 75%, Missing); colon: 43.4783% (minimum 65%, Approved); duodenum: 39.4737% (minimum 70%, Approved); pancreas: 62.5000% (minimum 70%, Approved); rectum: 42.2535% (minimum 65%, Approved); retina: 54.5455% (minimum 75%, Missing); skeletal muscle: 44.1176% (minimum 70%, Approved); small intestine: 56.6038% (minimum 70%, Approved); smooth muscle: 60.0000% (minimum 75%, Missing); stomach: 52.6316% (minimum 65%, Approved); urinary bladder: 63.8298% (minimum 65%, Approved)",0.160811,-0.227465,-0.305263,0,2,partial,4.6,4.1,0.8,"duodenum: 4.6 nTPM (vital, limit 2); rectum: 4.1 nTPM (protected, limit 4); skeletal muscle: 3.8 nTPM (vital, limit 2); retina: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 2); smooth muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); cerebral cortex / synapses: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / synapses: Low (Approved); smooth muscle / smooth muscle cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CHRNA5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000169717,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,7,partial,0,0,0,,small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ACTRT2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Wang 2016;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000169760,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 52.2727% (minimum 75%, Missing); basal ganglia: 55.4217% (minimum 75%, Missing); cerebellum: 48.9362% (minimum 75%, Missing); cerebral cortex: 27.2189% (minimum 75%, Missing); heart muscle: 63.0137% (minimum 75%, Missing); hippocampal formation: 50.5495% (minimum 75%, Missing); hypothalamus: 51.1111% (minimum 75%, Missing); kidney: 67.6471% (minimum 75%, Missing); midbrain: 60.5263% (minimum 75%, Missing); pituitary gland: 73.0159% (minimum 75%, Missing); retina: 30.0654% (minimum 75%, Missing); spinal cord: 65.7143% (minimum 75%, Missing); urinary bladder: 67.6471% (minimum 70%, Missing)",0.201852,-0.0235294,-0.477811,0,9,partial,12.3,2.2,1.6,"cerebral cortex: 12.3 nTPM (vital, limit 1); retina: 10.7 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); duodenum / glandular cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),49,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; thymus; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NLGN1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000169777,True,compatible,,True,True,True,,0.35,0.286486,0.223333,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TAS2R1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000169800,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RBMY1F,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000169918,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 39.6040% (minimum 75%, Missing); basal ganglia: 41.6667% (minimum 75%, Missing); cerebellum: 25.0000% (minimum 75%, Missing); cerebral cortex: 33.8983% (minimum 75%, Missing); hippocampal formation: 33.3333% (minimum 75%, Missing); hypothalamus: 43.0108% (minimum 75%, Missing); midbrain: 37.3832% (minimum 75%, Missing); pituitary gland: 72.7273% (minimum 75%, Missing); retina: 72.7273% (minimum 75%, Missing); skin: 61.5385% (minimum 65%, Missing); spinal cord: 28.9855% (minimum 75%, Missing)",-0.0346154,0.054717,-0.5,0,80,unavailable,12,1.3,2.5,"cerebellum: 12 nTPM (vital, limit 1); spinal cord: 9.8 nTPM (vital, limit 1); hippocampal formation: 8 nTPM (vital, limit 1); cerebral cortex: 7.8 nTPM (vital, limit 1); midbrain: 6.7 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); basal ganglia: 5.6 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OTUD7A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000169953,True,compatible,,True,True,True,,0.35,0.3,0.221564,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HSFY2,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000170100,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.4444% (minimum 75%, Missing); amygdala: 73.5294% (minimum 75%, Missing); basal ganglia: 72.4638% (minimum 75%, Missing); cerebellum: 59.5238% (minimum 75%, Missing); cerebral cortex: 63.2911% (minimum 75%, Missing); colon: 69.4444% (minimum 70%, Missing); heart muscle: 69.4444% (minimum 75%, Missing); hippocampal formation: 73.5294% (minimum 75%, Missing); hypothalamus: 73.5294% (minimum 75%, Missing); kidney: 61.7284% (minimum 75%, Missing); liver: 71.4286% (minimum 75%, Missing); lung: 70.4225% (minimum 75%, Missing); midbrain: 73.5294% (minimum 75%, Missing); pancreas: 50.5051% (minimum 75%, Missing); parathyroid gland: 39.0625% (minimum 70%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 56.8182% (minimum 75%, Missing); salivary gland: 67.5676% (minimum 70%, Missing); skeletal muscle: 57.4713% (minimum 75%, Missing); skin: 61.7284% (minimum 65%, Missing); small intestine: 74.6269% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 69.4444% (minimum 75%, Missing); stomach: 68.4932% (minimum 70%, Missing); thyroid gland: 62.5000% (minimum 65%, Missing); tongue: 54.9451% (minimum 70%, Missing)",-0.032716,-0.309375,-0.244949,0,0,routine_complete,4.9,7.8,3.1,"parathyroid gland: 7.8 nTPM (protected, limit 3); pancreas: 4.9 nTPM (vital, limit 1); tongue: 4.1 nTPM (protected, limit 3); retina: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.7 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF778,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000170160,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 55.0562% (minimum 60%, Enhanced); cerebellum: 62.4204% (minimum 75%, Missing); retina: 43.9462% (minimum 75%, Missing)",0.0450355,0.130508,-0.310538,0,3,partial,12.5,2.2,4.3,"retina: 12.5 nTPM (vital, limit 1); bone marrow: 8 nTPM (vital, limit 6); cerebellum: 5.9 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC144A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000170236,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"kidney: 71.4286% (minimum 75%, Missing)",0.183333,0.2375,-0.0357143,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,USP50,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000170264,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 71.0526% (minimum 75%, Missing); cerebral cortex: 72.9730% (minimum 75%, Missing); choroid plexus: 60.0000% (minimum 75%, Missing); hypothalamus: 72.9730% (minimum 75%, Missing); kidney: 73.9726% (minimum 75%, Missing); pituitary gland: 69.2308% (minimum 75%, Missing); retina: 16.1194% (minimum 75%, Missing); stomach: 68.3544% (minimum 70%, Missing)",0.00674157,-0.0164557,-0.588806,0,4,partial,28.1,2.5,3.5,"retina: 28.1 nTPM (vital, limit 1); choroid plexus: 3.6 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 2); cerebral cortex: 2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebral cortex / endothelial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM161A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000170279,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 13.3333% (minimum 75%, Missing)",0.35,0.3,-0.616667,0,80,unavailable,1.3,0,0,"retina: 1.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C7orf33,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000170469,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.329438,0.185927,0.170747,0,2,partial,22.2,18.4,7,"skeletal muscle: 22.2 nTPM (vital, limit 6); heart muscle: 19.9 nTPM (vital, limit 6); tongue: 18.4 nTPM (protected, limit 3); kidney: 14.4 nTPM (vital, limit 6); pituitary gland: 12.3 nTPM (vital, limit 1); choroid plexus: 9.7 nTPM (vital, limit 1); adrenal gland: 6.9 nTPM (vital, limit 6); small intestine: 6.9 nTPM (vital, limit 6); duodenum: 6.3 nTPM (vital, limit 6); retina: 6.3 nTPM (vital, limit 1); amygdala: 6.1 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); midbrain: 5.9 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); spinal cord: 4.2 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA24,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000170486,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0427711,0.3,0.25,0,6,partial,2.1,2.8,10.2,"skin: 10.2 nTPM (manageable, limit 5)",,69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; hair / cells in cuticle; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KRT72,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000170498,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349558,0.299558,0.230936,0,4,partial,4.4,2.1,1.4,"basal ganglia: 4.4 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KISS1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000170516,True,compatible,,True,True,True,,0.348802,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,COX7B2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000170613,True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GARIN3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000170627,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.318348,0.299446,0.245039,0,2,partial,6,5.5,5.9,"bone marrow: 6 nTPM (vital, limit 2); thymus: 5.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 4)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GTSF1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000170703,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.344565,0.135616,0.0456522,0,9,partial,4.7,3.6,0.1,"choroid plexus: 4.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced),84,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TTLL6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000170734,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.5714% (minimum 75%, Missing); bone marrow: 71.5278% (minimum 75%, Missing); choroid plexus: 71.5278% (minimum 75%, Missing); colon: 60.5882% (minimum 70%, Missing); duodenum: 70.0680% (minimum 75%, Missing); esophagus: 66.0256% (minimum 70%, Missing); heart muscle: 74.6377% (minimum 75%, Missing); kidney: 69.5946% (minimum 75%, Missing); liver: 65.6051% (minimum 75%, Missing); lung: 65.1899% (minimum 75%, Missing); lymph node: 44.9782% (minimum 70%, Missing); pancreas: 66.4516% (minimum 75%, Missing); rectum: 59.8837% (minimum 70%, Missing); retina: 58.8571% (minimum 75%, Missing); skeletal muscle: 55.6757% (minimum 75%, Missing); skin: 55.6757% (minimum 65%, Missing); small intestine: 70.5479% (minimum 75%, Missing); smooth muscle: 63.1902% (minimum 75%, Missing); thymus: 45.1754% (minimum 65%, Missing); thyroid gland: 60.9467% (minimum 65%, Missing); tongue: 69.5946% (minimum 70%, Missing); urinary bladder: 69.1275% (minimum 70%, Missing)",-0.198246,-0.250218,-0.193243,0,1,partial,8.2,12.6,12.5,"lymph node: 12.6 nTPM (protected, limit 3); thymus: 12.5 nTPM (manageable, limit 5); skeletal muscle: 8.2 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); rectum: 6.9 nTPM (protected, limit 3); colon: 6.7 nTPM (protected, limit 3); thyroid gland: 6.6 nTPM (manageable, limit 5); smooth muscle: 6 nTPM (vital, limit 1); lung: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); esophagus: 5.3 nTPM (protected, limit 3); pancreas: 5.2 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 3); kidney: 4.5 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 3); stomach: 4.4 nTPM (protected, limit 3); duodenum: 4.4 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); salivary gland: 3.9 nTPM (protected, limit 3); adrenal gland: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); heart muscle: 3.5 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,POLH,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000170748,True,compatible,,True,True,True,,0.35,0.3,0.247143,0,2,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RBMXL2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000170777,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TPD52L3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000170782,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR10A4,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000170788,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349188,0.3,0.237952,0,80,unavailable,1.5,0,0.1,"choroid plexus: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DYDC1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000170820,True,compatible,,True,True,True,,0.314286,0.3,0.15,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FSHR,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000170848,True,compatible,,True,True,True,,0.35,0.3,0.247921,0,2,partial,1.4,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PSG6,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",True,True,True,True,False,unchanged,
ENSG00000170873,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.2784% (minimum 65%, Missing); adrenal gland: 49.5690% (minimum 75%, Missing); amygdala: 63.1868% (minimum 75%, Missing); basal ganglia: 68.4524% (minimum 75%, Missing); bone marrow: 73.7179% (minimum 75%, Missing); cerebellum: 44.7471% (minimum 75%, Missing); cerebral cortex: 59.7920% (minimum 75%, Missing); esophagus: 44.1176% (minimum 70%, Missing); heart muscle: 67.6471% (minimum 70%, Approved); hippocampal formation: 63.3028% (minimum 75%, Missing); hypothalamus: 63.6531% (minimum 75%, Missing); kidney: 59.6886% (minimum 75%, Missing); liver: 32.7947% (minimum 75%, Missing); lung: 68.4524% (minimum 70%, Approved); lymph node: 68.8623% (minimum 70%, Missing); midbrain: 62.8415% (minimum 75%, Missing); pancreas: 55.5556% (minimum 75%, Missing); retina: 70.2648% (minimum 75%, Missing); skeletal muscle: 52.5114% (minimum 75%, Missing); skin: 53.6547% (minimum 65%, Missing); spinal cord: 52.1936% (minimum 75%, Missing); spleen: 50.6608% (minimum 65%, Missing); tongue: 59.2784% (minimum 70%, Missing); urinary bladder: 69.6970% (minimum 70%, Missing)",-0.143392,-0.258824,-0.422053,0,2,partial,70.7,43.7,33.6,"liver: 70.7 nTPM (vital, limit 1); esophagus: 43.7 nTPM (protected, limit 3); cerebellum: 42.6 nTPM (vital, limit 1); adrenal gland: 35.1 nTPM (vital, limit 1); spleen: 33.6 nTPM (manageable, limit 5); spinal cord: 31.6 nTPM (vital, limit 1); skeletal muscle: 31.2 nTPM (vital, limit 1); skin: 29.8 nTPM (manageable, limit 5); pancreas: 27.6 nTPM (vital, limit 1); adipose tissue: 23.7 nTPM (manageable, limit 5); tongue: 23.7 nTPM (protected, limit 3); kidney: 23.3 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); midbrain: 20.4 nTPM (vital, limit 1); amygdala: 20.1 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); hypothalamus: 19.7 nTPM (vital, limit 1); thymus: 17.9 nTPM (manageable, limit 5); heart muscle: 16.5 nTPM (vital, limit 2); lung: 15.9 nTPM (vital, limit 2); basal ganglia: 15.9 nTPM (vital, limit 1); lymph node: 15.6 nTPM (protected, limit 3); urinary bladder: 15 nTPM (protected, limit 3); retina: 14.6 nTPM (vital, limit 1); salivary gland: 13.5 nTPM (protected, limit 3); bone marrow: 12.3 nTPM (vital, limit 1); stomach: 11.7 nTPM (protected, limit 3); pituitary gland: 10.7 nTPM (vital, limit 1); colon: 10.7 nTPM (protected, limit 3); choroid plexus: 10.4 nTPM (vital, limit 1); smooth muscle: 9.3 nTPM (vital, limit 2); rectum: 8.8 nTPM (protected, limit 3); small intestine: 7.7 nTPM (vital, limit 1); duodenum: 6.3 nTPM (vital, limit 1); thyroid gland: 5.9 nTPM (manageable, limit 5); parathyroid gland: 3.6 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MTSS1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000170903,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.1837% (minimum 60%, Approved); adrenal gland: 54.2056% (minimum 75%, Missing); amygdala: 52.2523% (minimum 75%, Missing); basal ganglia: 54.7170% (minimum 75%, Missing); cerebellum: 52.2523% (minimum 75%, Missing); cerebral cortex: 42.3358% (minimum 75%, Missing); choroid plexus: 61.0526% (minimum 75%, Missing); colon: 62.7027% (minimum 70%, Missing); duodenum: 69.4611% (minimum 75%, Missing); esophagus: 60.1036% (minimum 65%, Approved); heart muscle: 43.4457% (minimum 75%, Missing); hippocampal formation: 53.7037% (minimum 75%, Missing); hypothalamus: 54.2056% (minimum 75%, Missing); kidney: 55.7692% (minimum 75%, Missing); liver: 63.0435% (minimum 70%, Approved); lung: 58.5859% (minimum 75%, Missing); lymph node: 54.9763% (minimum 65%, Approved); midbrain: 52.7273% (minimum 75%, Missing); pancreas: 56.0386% (minimum 70%, Approved); parathyroid gland: 59.4872% (minimum 65%, Approved); pituitary gland: 55.2381% (minimum 75%, Missing); rectum: 65.5367% (minimum 70%, Missing); retina: 26.5446% (minimum 75%, Missing); salivary gland: 62.3656% (minimum 70%, Missing); skeletal muscle: 50.4348% (minimum 75%, Missing); small intestine: 67.4419% (minimum 75%, Missing); smooth muscle: 53.4562% (minimum 70%, Approved); spinal cord: 55.5024% (minimum 75%, Missing); spleen: 58.5859% (minimum 60%, Approved); stomach: 62.3656% (minimum 70%, Missing); thymus: 58.8832% (minimum 65%, Missing); thyroid gland: 47.5410% (minimum 65%, Missing); tongue: 41.8773% (minimum 70%, Missing); urinary bladder: 57.7114% (minimum 65%, Approved)",-0.17459,-0.281227,-0.484554,0,7,partial,32.1,16.1,12.8,"retina: 32.1 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 3); cerebral cortex: 15.8 nTPM (vital, limit 1); heart muscle: 15.1 nTPM (vital, limit 1); thyroid gland: 12.8 nTPM (manageable, limit 5); skeletal muscle: 11.4 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); midbrain: 10.4 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 2); hippocampal formation: 10 nTPM (vital, limit 1); adrenal gland: 9.8 nTPM (vital, limit 1); hypothalamus: 9.8 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.5 nTPM (protected, limit 4); pituitary gland: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); kidney: 9.2 nTPM (vital, limit 1); pancreas: 9.1 nTPM (vital, limit 2); urinary bladder: 8.5 nTPM (protected, limit 4); lung: 8.2 nTPM (vital, limit 1); thymus: 8.1 nTPM (manageable, limit 5); parathyroid gland: 7.9 nTPM (protected, limit 4); esophagus: 7.7 nTPM (protected, limit 4); choroid plexus: 7.4 nTPM (vital, limit 1); salivary gland: 7 nTPM (protected, limit 3); stomach: 7 nTPM (protected, limit 3); colon: 6.9 nTPM (protected, limit 3); liver: 6.8 nTPM (vital, limit 2); rectum: 6.1 nTPM (protected, limit 3); small intestine: 5.6 nTPM (vital, limit 1); duodenum: 5.1 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MSANTD4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000170925,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX13B,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000170946,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.1481% (minimum 60%, Approved); adrenal gland: 51.5873% (minimum 75%, Missing); amygdala: 54.1667% (minimum 75%, Missing); basal ganglia: 54.1667% (minimum 75%, Missing); cerebellum: 47.4453% (minimum 70%, Approved); cerebral cortex: 50.3876% (minimum 75%, Missing); choroid plexus: 71.4286% (minimum 75%, Missing); colon: 58.5586% (minimum 70%, Missing); duodenum: 60.1852% (minimum 70%, Approved); esophagus: 56.0345% (minimum 70%, Missing); heart muscle: 36.5169% (minimum 75%, Missing); hippocampal formation: 53.7190% (minimum 75%, Missing); hypothalamus: 52.4194% (minimum 75%, Missing); kidney: 51.5873% (minimum 75%, Missing); liver: 52.8455% (minimum 70%, Approved); lung: 60.7477% (minimum 75%, Missing); lymph node: 49.6183% (minimum 65%, Approved); midbrain: 53.2787% (minimum 75%, Missing); pancreas: 47.7941% (minimum 75%, Missing); parathyroid gland: 58.5586% (minimum 70%, Missing); pituitary gland: 59.0909% (minimum 75%, Missing); rectum: 60.7477% (minimum 65%, Approved); retina: 45.4545% (minimum 75%, Missing); salivary gland: 53.7190% (minimum 70%, Missing); skeletal muscle: 28.3843% (minimum 70%, Approved); skin: 43.3333% (minimum 65%, Missing); small intestine: 60.1852% (minimum 70%, Approved); smooth muscle: 51.5873% (minimum 70%, Approved); spinal cord: 52.4194% (minimum 75%, Missing); spleen: 53.2787% (minimum 60%, Approved); stomach: 57.0175% (minimum 70%, Missing); thymus: 56.5217% (minimum 65%, Missing); thyroid gland: 50.7812% (minimum 65%, Missing); tongue: 37.3563% (minimum 70%, Missing); urinary bladder: 54.6218% (minimum 65%, Approved)",-0.216667,-0.326437,-0.416157,0,7,partial,16.4,10.9,8.5,"skeletal muscle: 16.4 nTPM (vital, limit 2); heart muscle: 11.3 nTPM (vital, limit 1); tongue: 10.9 nTPM (protected, limit 3); skin: 8.5 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); cerebellum: 7.2 nTPM (vital, limit 2); pancreas: 7.1 nTPM (vital, limit 1); lymph node: 6.6 nTPM (protected, limit 4); cerebral cortex: 6.4 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); adrenal gland: 6.1 nTPM (vital, limit 1); smooth muscle: 6.1 nTPM (vital, limit 2); kidney: 6.1 nTPM (vital, limit 1); spinal cord: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 2); midbrain: 5.7 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 3); hippocampal formation: 5.6 nTPM (vital, limit 1); amygdala: 5.5 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 4); esophagus: 5.1 nTPM (protected, limit 3); stomach: 4.9 nTPM (protected, limit 3); parathyroid gland: 4.6 nTPM (protected, limit 3); colon: 4.6 nTPM (protected, limit 3); pituitary gland: 4.5 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 2); duodenum: 4.3 nTPM (vital, limit 2); rectum: 4.2 nTPM (protected, limit 4); lung: 4.2 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAJC24,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000170948,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,7,partial,0.7,0,0,,kidney / proximal tubules (cell body): Medium (Supported),57,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MBD3L1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000170950,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PGK2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000170953,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR8B12,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000170965,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0.1,0.2,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PLAC1,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016",True,True,True,True,True,unchanged,
ENSG00000170967,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DDI1,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000171060,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C8orf74,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000171094,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 70.5882% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); cerebral cortex: 41.3793% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); hypothalamus: 60.0000% (minimum 75%, Missing); midbrain: 75.0000% (minimum 75%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); retina: 63.1579% (minimum 75%, Missing)",0.15,-0.0333333,-0.336207,0,1,partial,1.7,0.6,0.3,"cerebral cortex: 1.7 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ALK,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000171102,True,compatible,,True,True,True,,0.15,0.3,0.239691,0,80,unavailable,0.1,0,2.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OBP2B,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000171121,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 48.9130% (minimum 60%, Approved); adrenal gland: 56.2500% (minimum 75%, Missing); amygdala: 51.1364% (minimum 75%, Missing); basal ganglia: 49.4505% (minimum 75%, Missing); cerebellum: 37.1901% (minimum 70%, Approved); cerebral cortex: 40.5405% (minimum 70%, Approved); choroid plexus: 67.1642% (minimum 75%, Missing); colon: 53.5714% (minimum 70%, Missing); duodenum: 73.7705% (minimum 75%, Missing); esophagus: 69.2308% (minimum 70%, Missing); heart muscle: 56.9620% (minimum 75%, Missing); hippocampal formation: 45.0000% (minimum 75%, Missing); hypothalamus: 48.3871% (minimum 75%, Missing); kidney: 49.4505% (minimum 75%, Missing); liver: 45.4545% (minimum 75%, Missing); lung: 60.8108% (minimum 70%, Approved); midbrain: 48.3871% (minimum 75%, Missing); pancreas: 46.8750% (minimum 75%, Missing); pituitary gland: 58.4416% (minimum 75%, Missing); retina: 61.6438% (minimum 75%, Missing); salivary gland: 60.0000% (minimum 65%, Approved); small intestine: 56.9620% (minimum 75%, Missing); spinal cord: 52.9412% (minimum 75%, Missing); spleen: 38.1356% (minimum 60%, Approved); stomach: 55.5556% (minimum 70%, Missing); thyroid gland: 59.2105% (minimum 60%, Approved); urinary bladder: 55.5556% (minimum 70%, Missing)",-0.218644,-0.164286,-0.328099,0,3,partial,7.6,3.9,7.3,"cerebellum: 7.6 nTPM (vital, limit 2); cerebral cortex: 6.6 nTPM (vital, limit 2); hippocampal formation: 5.5 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); pancreas: 5.1 nTPM (vital, limit 1); midbrain: 4.8 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); kidney: 4.6 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); amygdala: 4.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); colon: 3.9 nTPM (protected, limit 3); stomach: 3.6 nTPM (protected, limit 3); urinary bladder: 3.6 nTPM (protected, limit 3); adrenal gland: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); small intestine: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 2); retina: 2.8 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KCNMB3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000171133,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"amygdala: 66.6667% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 50.0000% (minimum 75%, Missing); midbrain: 28.5714% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); skeletal muscle: 28.5714% (minimum 75%, Missing); spinal cord: 20.0000% (minimum 75%, Missing)",0.35,0.3,-0.55,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR2K2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000171209,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349715,0.292219,0.25,0,2,partial,0.1,65.7,0.1,"salivary gland: 65.7 nTPM (protected, limit 12)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CSN3,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000171320,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 48.6957% (minimum 75%, Missing); colon: 60.8696% (minimum 70%, Missing); duodenum: 34.3558% (minimum 75%, Missing); lymph node: 55.4455% (minimum 70%, Missing); rectum: 57.7320% (minimum 70%, Missing); small intestine: 42.4242% (minimum 75%, Missing); stomach: 69.1358% (minimum 70%, Missing); thymus: 40.2878% (minimum 65%, Missing)",-0.247122,-0.145545,-0.406442,0,80,unavailable,10.7,4.5,8.3,"duodenum: 10.7 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); small intestine: 7.6 nTPM (vital, limit 1); bone marrow: 5.9 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 3); rectum: 4.1 nTPM (protected, limit 3); colon: 3.6 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ESCO2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000171402,True,compatible,,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,1.9,0.3,3,,,54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,XAGE3,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016",True,True,True,True,False,unchanged,
ENSG00000171405,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,XAGE5,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000171478,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.237234,0,1,partial,0.3,0.2,0.2,,,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,SPACA5B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000171481,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR1L3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000171487,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 22.7758% (minimum 70%, Missing)",0.35,-0.472242,0.25,0,80,unavailable,0,21.7,0,"parathyroid gland: 21.7 nTPM (protected, limit 3)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NLRP5,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000171489,True,compatible,,True,True,True,,0.342754,0.3,0.221631,0,1,partial,0.4,0.2,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPACA5,current_adaptive,True,False,True,False,10.1038/ncomms10499,Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000171492,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 32.4675% (minimum 75%, Missing); amygdala: 45.4545% (minimum 75%, Missing); basal ganglia: 42.2297% (minimum 75%, Missing); bone marrow: 47.1698% (minimum 75%, Missing); cerebellum: 60.3865% (minimum 75%, Missing); cerebral cortex: 37.6506% (minimum 75%, Missing); choroid plexus: 61.8812% (minimum 75%, Missing); colon: 41.9463% (minimum 70%, Missing); duodenum: 40.3226% (minimum 75%, Missing); esophagus: 62.1891% (minimum 70%, Missing); heart muscle: 63.1313% (minimum 75%, Missing); hippocampal formation: 33.4225% (minimum 75%, Missing); hypothalamus: 42.6621% (minimum 75%, Missing); kidney: 33.3333% (minimum 75%, Missing); liver: 35.4108% (minimum 75%, Missing); lung: 56.8182% (minimum 75%, Missing); lymph node: 33.9674% (minimum 70%, Missing); midbrain: 36.6569% (minimum 75%, Missing); pancreas: 49.8008% (minimum 75%, Missing); parathyroid gland: 62.8141% (minimum 70%, Missing); pituitary gland: 44.1696% (minimum 75%, Missing); rectum: 41.5282% (minimum 70%, Missing); retina: 51.8672% (minimum 75%, Missing); salivary gland: 34.4353% (minimum 70%, Missing); skeletal muscle: 60.0962% (minimum 75%, Missing); small intestine: 41.6667% (minimum 75%, Missing); smooth muscle: 53.1915% (minimum 75%, Missing); spinal cord: 22.7273% (minimum 75%, Missing); spleen: 34.9162% (minimum 65%, Missing); stomach: 52.7426% (minimum 70%, Missing); thymus: 31.6456% (minimum 65%, Missing); thyroid gland: 44.8029% (minimum 65%, Missing); urinary bladder: 53.6481% (minimum 70%, Missing)",-0.333544,-0.360326,-0.522727,0,80,unavailable,42.5,24.3,27,"spinal cord: 42.5 nTPM (vital, limit 1); thymus: 27 nTPM (manageable, limit 5); adrenal gland: 26 nTPM (vital, limit 1); kidney: 25 nTPM (vital, limit 1); hippocampal formation: 24.9 nTPM (vital, limit 1); lymph node: 24.3 nTPM (protected, limit 3); salivary gland: 23.8 nTPM (protected, limit 3); spleen: 23.3 nTPM (manageable, limit 5); liver: 22.8 nTPM (vital, limit 1); midbrain: 21.6 nTPM (vital, limit 1); cerebral cortex: 20.7 nTPM (vital, limit 1); duodenum: 18.5 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 3); small intestine: 17.5 nTPM (vital, limit 1); colon: 17.3 nTPM (protected, limit 3); basal ganglia: 17.1 nTPM (vital, limit 1); hypothalamus: 16.8 nTPM (vital, limit 1); pituitary gland: 15.8 nTPM (vital, limit 1); thyroid gland: 15.4 nTPM (manageable, limit 5); amygdala: 15 nTPM (vital, limit 1); bone marrow: 14 nTPM (vital, limit 1); pancreas: 12.6 nTPM (vital, limit 1); retina: 11.6 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 3); smooth muscle: 11 nTPM (vital, limit 1); urinary bladder: 10.8 nTPM (protected, limit 3); lung: 9.5 nTPM (vital, limit 1); skeletal muscle: 8.3 nTPM (vital, limit 1); cerebellum: 8.2 nTPM (vital, limit 1); choroid plexus: 7.7 nTPM (vital, limit 1); esophagus: 7.6 nTPM (protected, limit 3); parathyroid gland: 7.4 nTPM (protected, limit 3); heart muscle: 7.3 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); tongue: 3.3 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRRC8D,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000171495,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0.1,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MROH2B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000171505,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 33.3333% (minimum 75%, Missing)",0.35,0.3,-0.416667,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR1N1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000171533,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 36.9606% (minimum 75%, Missing); basal ganglia: 34.3206% (minimum 75%, Missing); cerebellum: 47.5845% (minimum 75%, Missing); cerebral cortex: 31.6975% (minimum 75%, Missing); choroid plexus: 30.6854% (minimum 75%, Missing); colon: 63.9610% (minimum 70%, Missing); hippocampal formation: 38.1783% (minimum 75%, Missing); hypothalamus: 34.2609% (minimum 75%, Missing); kidney: 70.4830% (minimum 75%, Missing); midbrain: 45.2354% (minimum 75%, Missing); pituitary gland: 34.5009% (minimum 75%, Missing); retina: 29.7358% (minimum 75%, Missing); spinal cord: 47.5271% (minimum 75%, Missing)",0.184746,-0.0603896,-0.452642,0,17,partial,93.1,22.2,7.8,"retina: 93.1 nTPM (vital, limit 1); choroid plexus: 89 nTPM (vital, limit 1); cerebral cortex: 84.9 nTPM (vital, limit 1); hypothalamus: 75.6 nTPM (vital, limit 1); basal ganglia: 75.4 nTPM (vital, limit 1); pituitary gland: 74.8 nTPM (vital, limit 1); amygdala: 67.2 nTPM (vital, limit 1); hippocampal formation: 63.8 nTPM (vital, limit 1); midbrain: 47.7 nTPM (vital, limit 1); spinal cord: 43.5 nTPM (vital, limit 1); cerebellum: 43.4 nTPM (vital, limit 1); colon: 22.2 nTPM (protected, limit 3); parathyroid gland: 21.3 nTPM (protected, limit 12); adrenal gland: 18.4 nTPM (vital, limit 6); kidney: 16.5 nTPM (vital, limit 1); smooth muscle: 12.6 nTPM (vital, limit 6); heart muscle: 8.3 nTPM (vital, limit 6); skin: 7.8 nTPM (manageable, limit 5); lung: 7.5 nTPM (vital, limit 6); small intestine: 4.6 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); duodenum: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): Low (Enhanced); bronchus / ciliated cells (tip of cilia): Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Low (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): Low (Enhanced); rectum / peripheral nerve/ganglion: High (Enhanced); skin 1 / cells in corneal layer: High (Enhanced); skin 1 / cells in granular layer: High (Enhanced); skin 1 / eccrine glands: Low (Enhanced); skin 2 / cells in corneal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / eccrine glands: Low (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced),123,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / cells in corneal layer; skin 1 / cells in granular layer; skin 1 / eccrine glands; skin 1 / hair follicles; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / eccrine glands; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAP6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000171540,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 50.0000% (minimum 75%, Missing); hypothalamus: 1.5267% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); spinal cord: 66.6667% (minimum 75%, Missing)",0.35,0.3,-0.734733,0,3,partial,12.9,0,0,"hypothalamus: 12.9 nTPM (vital, limit 1)",hypothalamus / neuronal cells: Medium (Enhanced),56,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OTP,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000171722,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343399,0.290132,0.156627,0,80,unavailable,3.1,0.3,0.2,"adrenal gland: 3.1 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA46,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000171757,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 68.8889% (minimum 75%, Missing); retina: 69.6629% (minimum 75%, Missing)",0.282331,0.26875,-0.0611111,0,6,partial,5.6,0.8,1.5,"choroid plexus: 5.6 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Medium (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRRC34,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000171772,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347106,0.277305,0.110175,0,1,partial,17.5,1.6,1.8,"cerebellum: 17.5 nTPM (vital, limit 6); cerebral cortex: 16.3 nTPM (vital, limit 6); basal ganglia: 11.2 nTPM (vital, limit 1); amygdala: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.9 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SYCE1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000171790,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340617,0.248652,0.22365,0,80,unavailable,2,4,0.7,"salivary gland: 4 nTPM (protected, limit 3); lung: 2 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLFNL1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000171794,True,compatible,,True,True,True,,0.35,0.3,0.233051,0,6,partial,0.1,0,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,UTF1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000171804,True,compatible,,True,True,True,,0.332143,0.3,0.243976,0,80,unavailable,0.1,0,0.3,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,WDR87,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000171827,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.7317% (minimum 75%, Missing); amygdala: 72.5000% (minimum 75%, Missing); basal ganglia: 71.6049% (minimum 75%, Missing); bone marrow: 72.5000% (minimum 75%, Missing); cerebellum: 68.2353% (minimum 75%, Missing); cerebral cortex: 68.2353% (minimum 75%, Missing); heart muscle: 70.7317% (minimum 75%, Missing); hippocampal formation: 71.6049% (minimum 75%, Missing); hypothalamus: 71.6049% (minimum 75%, Missing); kidney: 68.2353% (minimum 75%, Missing); lung: 74.3590% (minimum 75%, Missing); lymph node: 69.0476% (minimum 70%, Missing); midbrain: 68.2353% (minimum 75%, Missing); parathyroid gland: 59.7938% (minimum 70%, Missing); retina: 65.9091% (minimum 75%, Missing); smooth muscle: 72.5000% (minimum 75%, Missing); spinal cord: 63.0435% (minimum 75%, Missing); tongue: 68.2353% (minimum 70%, Missing)",0.00168539,-0.102062,-0.119565,0,2,partial,3.4,3.9,3.1,"parathyroid gland: 3.9 nTPM (protected, limit 3); spinal cord: 3.4 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF570,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000171847,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 52.6316% (minimum 75%, Missing); amygdala: 62.5000% (minimum 75%, Missing); basal ganglia: 50.0000% (minimum 75%, Missing); cerebellum: 47.6190% (minimum 75%, Missing); cerebral cortex: 22.7273% (minimum 75%, Missing); duodenum: 74.0741% (minimum 75%, Missing); esophagus: 64.5161% (minimum 70%, Missing); heart muscle: 57.1429% (minimum 75%, Missing); hippocampal formation: 60.6061% (minimum 75%, Missing); hypothalamus: 58.8235% (minimum 75%, Missing); kidney: 74.0741% (minimum 75%, Missing); lung: 60.6061% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); midbrain: 60.6061% (minimum 75%, Missing); pancreas: 54.0541% (minimum 75%, Missing); pituitary gland: 52.6316% (minimum 75%, Missing); retina: 30.7692% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing); skeletal muscle: 74.0741% (minimum 75%, Missing); skin: 47.6190% (minimum 65%, Missing); spinal cord: 66.6667% (minimum 75%, Missing); thyroid gland: 45.4545% (minimum 65%, Missing)",-0.195455,-0.2,-0.522727,0,80,unavailable,6.8,2,2.4,"cerebral cortex: 6.8 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM90A1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000171864,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 63.5860% (minimum 75%, Missing)",0.348549,0.298549,-0.11414,0,1,partial,39.4,1.9,0.2,"choroid plexus: 39.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRND,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000171872,True,compatible,,True,True,True,,0.35,0.3,0.237805,0,2,partial,1.1,1,0.1,,,52,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KLF17,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,False,gained,selectivity_revised
ENSG00000171931,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.27233,0.269388,0.12963,0,80,unavailable,1.3,0.3,0.8,"cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FBXW10,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Jamin 2021;Loriot 2025 · preferential;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000171956,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 75.0000% (minimum 75%, Missing); hypothalamus: 15.3846% (minimum 75%, Missing); midbrain: 12.7660% (minimum 75%, Missing); spinal cord: 31.5789% (minimum 75%, Missing)",0.35,0.05,-0.62234,0,80,unavailable,4.1,0.2,0,"midbrain: 4.1 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FOXB1,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000171988,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.8383% (minimum 65%, Missing); adrenal gland: 65.8754% (minimum 75%, Missing); bone marrow: 38.0137% (minimum 75%, Missing); cerebellum: 67.6829% (minimum 75%, Missing); cerebral cortex: 64.3478% (minimum 75%, Missing); colon: 68.0982% (minimum 70%, Missing); duodenum: 58.2677% (minimum 75%, Missing); esophagus: 65.2941% (minimum 70%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); kidney: 60.9890% (minimum 75%, Missing); liver: 51.9906% (minimum 75%, Missing); lung: 60.3261% (minimum 75%, Missing); lymph node: 51.7483% (minimum 70%, Missing); pancreas: 64.7230% (minimum 75%, Missing); parathyroid gland: 52.4823% (minimum 70%, Missing); rectum: 66.0714% (minimum 70%, Missing); retina: 36.6942% (minimum 75%, Missing); salivary gland: 64.7230% (minimum 70%, Missing); small intestine: 55.7789% (minimum 75%, Missing); smooth muscle: 60.8219% (minimum 75%, Missing); spleen: 53.1100% (minimum 65%, Missing); stomach: 62.1849% (minimum 70%, Missing); thymus: 54.2787% (minimum 65%, Missing); thyroid gland: 53.7530% (minimum 65%, Missing); tongue: 64.1618% (minimum 70%, Missing); urinary bladder: 60.4905% (minimum 70%, Missing)",-0.1189,-0.182517,-0.383058,0,1,partial,38.3,20.7,19.6,"retina: 38.3 nTPM (vital, limit 1); bone marrow: 36.2 nTPM (vital, limit 1); lymph node: 20.7 nTPM (protected, limit 3); liver: 20.5 nTPM (vital, limit 1); parathyroid gland: 20.1 nTPM (protected, limit 3); spleen: 19.6 nTPM (manageable, limit 5); thyroid gland: 19.1 nTPM (manageable, limit 5); thymus: 18.7 nTPM (manageable, limit 5); small intestine: 17.6 nTPM (vital, limit 1); duodenum: 15.9 nTPM (vital, limit 1); adipose tissue: 14.9 nTPM (manageable, limit 5); lung: 14.6 nTPM (vital, limit 1); urinary bladder: 14.5 nTPM (protected, limit 3); smooth muscle: 14.3 nTPM (vital, limit 1); kidney: 14.2 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 3); tongue: 12.4 nTPM (protected, limit 3); cerebral cortex: 12.3 nTPM (vital, limit 1); salivary gland: 12.1 nTPM (protected, limit 3); pancreas: 12.1 nTPM (vital, limit 1); esophagus: 11.8 nTPM (protected, limit 3); adrenal gland: 11.5 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 3); heart muscle: 11.1 nTPM (vital, limit 1); cerebellum: 10.6 nTPM (vital, limit 1); colon: 10.4 nTPM (protected, limit 3); skin: 10.4 nTPM (manageable, limit 5); skeletal muscle: 6.8 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,JMJD1C,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000171989,True,compatible,,True,True,True,,0.35,0.3,0.247475,0,1,partial,0.3,0.2,0.3,,,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LDHAL6B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000172073,True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPMIP9,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000172139,True,compatible,,True,True,True,,0.137879,0.287342,0.212963,0,80,unavailable,0.3,0.1,2.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC9C1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000172244,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lymph node: 59.7015% (minimum 70%, Missing); thymus: 53.3333% (minimum 65%, Missing)",-0.116667,-0.102985,0.0343137,0,3,partial,1.1,2.7,3.5,"bone marrow: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C5orf34,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000172288,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,50,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,CDY1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000172320,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); bone marrow: 33.3333% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); retina: 33.3333% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing); skin: 40.0000% (minimum 65%, Missing); stomach: 66.6667% (minimum 70%, Missing)",-0.25,-0.0333333,-0.416667,0,80,unavailable,0.4,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR5A1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000172352,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,50,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,CDY1B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000172361,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.343582,0.294859,0.0454779,0,6,partial,19.9,2.4,3.7,"choroid plexus: 19.9 nTPM (vital, limit 1); basal ganglia: 5.8 nTPM (vital, limit 1); hypothalamus: 5.1 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Medium (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP53,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000172362,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR5B12,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000172365,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 33.3333% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); retina: 33.3333% (minimum 75%, Missing)",0.35,-0.2,-0.416667,0,80,unavailable,0.2,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR5B2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000172421,True,compatible,,True,True,True,,0.285484,0.283051,0.216667,0,2,partial,0.2,0.1,0.4,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EFCAB3,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000172465,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"smooth muscle: 64.9405% (minimum 75%, Missing); urinary bladder: 64.1288% (minimum 70%, Missing)",0.195232,-0.0587121,-0.100595,0,7,partial,91.4,94.7,33.8,"urinary bladder: 94.7 nTPM (protected, limit 3); smooth muscle: 91.4 nTPM (vital, limit 1); colon: 59 nTPM (protected, limit 3); cerebellum: 56.2 nTPM (vital, limit 2); cerebral cortex: 55.1 nTPM (vital, limit 1); hypothalamus: 53.3 nTPM (vital, limit 1); skeletal muscle: 53.2 nTPM (vital, limit 2); adrenal gland: 53 nTPM (vital, limit 1); hippocampal formation: 43.2 nTPM (vital, limit 1); amygdala: 42.3 nTPM (vital, limit 1); stomach: 39 nTPM (protected, limit 4); basal ganglia: 37.7 nTPM (vital, limit 1); esophagus: 36.6 nTPM (protected, limit 3); adipose tissue: 33.8 nTPM (manageable, limit 10); pituitary gland: 33 nTPM (vital, limit 1); choroid plexus: 32.5 nTPM (vital, limit 1); tongue: 32.3 nTPM (protected, limit 3); midbrain: 31.4 nTPM (vital, limit 1); heart muscle: 31.1 nTPM (vital, limit 2); thyroid gland: 31 nTPM (manageable, limit 5); parathyroid gland: 30.8 nTPM (protected, limit 4); lung: 29.6 nTPM (vital, limit 1); small intestine: 28.3 nTPM (vital, limit 1); spinal cord: 28.1 nTPM (vital, limit 1); spleen: 25.6 nTPM (manageable, limit 10); kidney: 24.4 nTPM (vital, limit 1); pancreas: 19.7 nTPM (vital, limit 2); liver: 18.5 nTPM (vital, limit 2); skin: 16.8 nTPM (manageable, limit 5); rectum: 16.2 nTPM (protected, limit 3); salivary gland: 15.6 nTPM (protected, limit 3); duodenum: 14.7 nTPM (vital, limit 1); retina: 14.3 nTPM (vital, limit 1); lymph node: 13.7 nTPM (protected, limit 3); thymus: 11.9 nTPM (manageable, limit 5); bone marrow: 9.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TCEAL1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000172468,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.290385,0.186364,0,80,unavailable,0.7,0.1,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,HSFY1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000172519,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); bone marrow: 25.0000% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); lymph node: 66.6667% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 40.0000% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 25.0000% (minimum 75%, Missing); skin: 40.0000% (minimum 65%, Missing); small intestine: 66.6667% (minimum 75%, Missing); stomach: 66.6667% (minimum 70%, Missing)",-0.25,-0.0333333,-0.5,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR10H5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000172538,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM170B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000172671,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.27132,0.183212,0.148515,0,5,partial,6.6,4.8,3.3,"cerebellum: 6.6 nTPM (vital, limit 6); lymph node: 4.8 nTPM (protected, limit 3); spinal cord: 4.1 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1)",duodenum / glandular cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZFAND4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000172680,True,compatible,,True,True,True,,0.35,0.3,0.125,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MOS,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000172717,True,compatible,,True,True,True,,0.333122,0.291489,0.216805,0,80,unavailable,0.8,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GARIN2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000172733,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 34.2466% (minimum 75%, Missing); basal ganglia: 28.0899% (minimum 75%, Missing); cerebellum: 17.8571% (minimum 75%, Missing); cerebral cortex: 31.2500% (minimum 75%, Missing); choroid plexus: 65.7895% (minimum 75%, Missing); hippocampal formation: 34.2466% (minimum 75%, Missing); hypothalamus: 34.2466% (minimum 75%, Missing); midbrain: 39.6825% (minimum 75%, Missing); pituitary gland: 46.2963% (minimum 75%, Missing); retina: 37.3134% (minimum 75%, Missing); spinal cord: 40.3226% (minimum 75%, Missing)",0.311538,0.192857,-0.571429,0,5,partial,11.5,0.3,0.4,"cerebellum: 11.5 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); retina: 4.2 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / molecular layer cells - nucleus: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin 2 / epidermal cells; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PURG,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000172738,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.25625,0.105556,0,0,80,unavailable,2.9,2.1,0.9,"adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TMEM217,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000172771,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 64.4068% (minimum 75%, Missing)",0.290594,0.22233,-0.105932,0,80,unavailable,10.5,1.6,1.2,"choroid plexus: 10.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EFCAB12,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000172785,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.4554% (minimum 60%, Approved); adrenal gland: 39.1459% (minimum 75%, Missing); amygdala: 63.0372% (minimum 75%, Missing); basal ganglia: 58.8235% (minimum 75%, Missing); bone marrow: 63.0372% (minimum 75%, Missing); cerebellum: 60.4396% (minimum 75%, Missing); cerebral cortex: 62.6781% (minimum 75%, Missing); choroid plexus: 41.1985% (minimum 75%, Missing); colon: 57.2917% (minimum 70%, Missing); duodenum: 62.8571% (minimum 75%, Missing); esophagus: 45.7380% (minimum 70%, Missing); heart muscle: 52.3810% (minimum 75%, Missing); hippocampal formation: 66.2651% (minimum 75%, Missing); hypothalamus: 58.5106% (minimum 75%, Missing); kidney: 36.0656% (minimum 75%, Missing); liver: 45.0820% (minimum 75%, Missing); lung: 57.8947% (minimum 75%, Missing); lymph node: 62.1469% (minimum 70%, Missing); midbrain: 62.1469% (minimum 75%, Missing); pancreas: 42.9688% (minimum 75%, Missing); parathyroid gland: 36.9748% (minimum 70%, Missing); pituitary gland: 53.7897% (minimum 75%, Missing); rectum: 58.9812% (minimum 70%, Missing); retina: 44.9898% (minimum 75%, Missing); salivary gland: 48.4581% (minimum 70%, Missing); skeletal muscle: 51.0441% (minimum 75%, Missing); skin: 50.4587% (minimum 65%, Missing); small intestine: 61.6246% (minimum 75%, Missing); smooth muscle: 65.0888% (minimum 75%, Missing); spinal cord: 66.6667% (minimum 75%, Missing); spleen: 57.1429% (minimum 65%, Missing); stomach: 54.1872% (minimum 70%, Missing); thymus: 62.3229% (minimum 65%, Missing); thyroid gland: 46.7091% (minimum 65%, Missing); tongue: 55.5556% (minimum 70%, Missing); urinary bladder: 48.2456% (minimum 70%, Missing)",-0.182909,-0.330252,-0.389344,0,4,partial,39,37.5,25.1,"kidney: 39 nTPM (vital, limit 1); parathyroid gland: 37.5 nTPM (protected, limit 3); adrenal gland: 34.2 nTPM (vital, limit 1); choroid plexus: 31.4 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); retina: 26.9 nTPM (vital, limit 1); liver: 26.8 nTPM (vital, limit 1); esophagus: 26.1 nTPM (protected, limit 3); thyroid gland: 25.1 nTPM (manageable, limit 5); urinary bladder: 23.6 nTPM (protected, limit 3); salivary gland: 23.4 nTPM (protected, limit 3); skin: 21.6 nTPM (manageable, limit 5); skeletal muscle: 21.1 nTPM (vital, limit 1); heart muscle: 20 nTPM (vital, limit 1); pituitary gland: 18.9 nTPM (vital, limit 1); stomach: 18.6 nTPM (protected, limit 3); adipose tissue: 18.4 nTPM (manageable, limit 10); tongue: 17.6 nTPM (protected, limit 3); spleen: 16.5 nTPM (manageable, limit 5); colon: 16.4 nTPM (protected, limit 3); lung: 16 nTPM (vital, limit 1); hypothalamus: 15.6 nTPM (vital, limit 1); basal ganglia: 15.4 nTPM (vital, limit 1); rectum: 15.3 nTPM (protected, limit 3); cerebellum: 14.4 nTPM (vital, limit 1); small intestine: 13.7 nTPM (vital, limit 1); lymph node: 13.4 nTPM (protected, limit 3); midbrain: 13.4 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); cerebral cortex: 13.1 nTPM (vital, limit 1); duodenum: 13 nTPM (vital, limit 1); amygdala: 12.9 nTPM (vital, limit 1); bone marrow: 12.9 nTPM (vital, limit 1); smooth muscle: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); spinal cord: 11 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNG1A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000172840,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.7477% (minimum 65%, Missing); adrenal gland: 67.9487% (minimum 75%, Missing); amygdala: 64.6341% (minimum 75%, Missing); basal ganglia: 66.2500% (minimum 75%, Missing); cerebellum: 54.6392% (minimum 75%, Missing); cerebral cortex: 51.9608% (minimum 75%, Missing); choroid plexus: 57.6087% (minimum 75%, Missing); colon: 58.8889% (minimum 70%, Missing); duodenum: 50.0000% (minimum 75%, Missing); esophagus: 59.5506% (minimum 70%, Missing); hippocampal formation: 65.4321% (minimum 75%, Missing); hypothalamus: 65.4321% (minimum 75%, Missing); kidney: 37.3239% (minimum 75%, Missing); liver: 38.9706% (minimum 75%, Missing); lung: 61.6279% (minimum 75%, Missing); lymph node: 67.9487% (minimum 70%, Missing); midbrain: 62.3529% (minimum 75%, Missing); pancreas: 54.6392% (minimum 75%, Missing); parathyroid gland: 47.3214% (minimum 70%, Missing); pituitary gland: 64.6341% (minimum 75%, Missing); rectum: 57.6087% (minimum 70%, Missing); retina: 52.4752% (minimum 75%, Missing); salivary gland: 60.2273% (minimum 70%, Missing); skeletal muscle: 67.9487% (minimum 75%, Missing); small intestine: 63.0952% (minimum 75%, Missing); smooth muscle: 72.6027% (minimum 75%, Missing); spinal cord: 69.7368% (minimum 75%, Missing); stomach: 64.6341% (minimum 70%, Missing); thyroid gland: 37.0629% (minimum 65%, Missing); tongue: 57.6087% (minimum 70%, Missing)",-0.279371,-0.226786,-0.376761,0,3,partial,8.9,5.9,9,"thyroid gland: 9 nTPM (manageable, limit 5); kidney: 8.9 nTPM (vital, limit 1); liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 3); adipose tissue: 5.8 nTPM (manageable, limit 5); duodenum: 5.3 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); pancreas: 4.4 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); tongue: 3.9 nTPM (protected, limit 3); choroid plexus: 3.9 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 3); esophagus: 3.6 nTPM (protected, limit 3); salivary gland: 3.5 nTPM (protected, limit 3); lung: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PDP2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000172967,True,compatible,,True,True,True,,0.3375,0.3,0.2375,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,XKR3,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000173093,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344083,0.3,0.115979,0,80,unavailable,2.6,0,0.1,"skeletal muscle: 2.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC63,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000173157,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 45.4545% (minimum 75%, Missing)",0.35,0.3,-0.295455,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ADAMTS20,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000173213,False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,True,True,True,,0.35,0.3,0.25,9,3,partial,0,0,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TUBB8B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential,False,False,False,False,False,unchanged,
ENSG00000173258,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 58.2734% (minimum 75%, Missing); bone marrow: 70.4348% (minimum 75%, Missing); cerebellum: 65.8537% (minimum 75%, Missing); cerebral cortex: 43.3155% (minimum 75%, Missing); choroid plexus: 51.5924% (minimum 75%, Missing); parathyroid gland: 68.0672% (minimum 70%, Missing); pituitary gland: 58.2734% (minimum 75%, Missing); retina: 41.7526% (minimum 75%, Missing); spinal cord: 74.3119% (minimum 75%, Missing); thyroid gland: 58.2734% (minimum 65%, Missing)",-0.0672662,-0.0193277,-0.332474,0,80,unavailable,11.3,3.8,5.8,"retina: 11.3 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); choroid plexus: 7.6 nTPM (vital, limit 1); adrenal gland: 5.8 nTPM (vital, limit 1); pituitary gland: 5.8 nTPM (vital, limit 1); thyroid gland: 5.8 nTPM (manageable, limit 5); cerebellum: 4.2 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 3); bone marrow: 3.4 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF483,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000173261,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.307219,0.278142,0.131773,0,80,unavailable,2.4,0.4,0.8,"spinal cord: 2.4 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PLAC8L1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000173262,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.347487,0.3,0.17757,0,9,partial,6.4,1.5,1.8,"pancreas: 6.4 nTPM (vital, limit 3); bone marrow: 6.2 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Supported),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC2A14,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Bruggeman 2018;Gong 2021 · reproductive coding;Loriot 2025 · preferential,False,False,False,False,False,unchanged,
ENSG00000173335,True,compatible,,True,True,True,,0.35,0.3,0.2,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CST9,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000173389,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IQCF1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000173401,True,compatible,,True,True,True,,0.35,0.296845,0.240596,0,2,partial,0.4,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GLIPR1L1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000173421,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.292361,0.269811,0.201852,0,3,partial,1.4,1.1,3.1,"choroid plexus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IHO1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000173431,False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.2,53.2,0.2,"salivary gland: 53.2 nTPM (protected, limit 3)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RNASE8,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000173451,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.1722% (minimum 65%, Missing); adrenal gland: 41.1215% (minimum 75%, Missing); bone marrow: 54.6584% (minimum 75%, Missing); lymph node: 69.5652% (minimum 70%, Missing); pituitary gland: 61.9718% (minimum 75%, Missing); retina: 61.7544% (minimum 75%, Missing); urinary bladder: 39.2857% (minimum 65%, Approved)",-0.118278,-0.257143,-0.338785,0,5,partial,25.2,27.2,15.5,"urinary bladder: 27.2 nTPM (protected, limit 4); adrenal gland: 25.2 nTPM (vital, limit 1); adipose tissue: 15.5 nTPM (manageable, limit 5); bone marrow: 14.6 nTPM (vital, limit 1); retina: 10.9 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 3); cerebellum: 6.4 nTPM (vital, limit 2); esophagus: 6.4 nTPM (protected, limit 3); stomach: 6.2 nTPM (protected, limit 3); spinal cord: 5.6 nTPM (vital, limit 1); skin: 5.5 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 3); duodenum: 5.5 nTPM (vital, limit 1); kidney: 5.4 nTPM (vital, limit 1); tongue: 5.4 nTPM (protected, limit 3); thymus: 5.3 nTPM (manageable, limit 5); heart muscle: 5 nTPM (vital, limit 1); cerebral cortex: 4.9 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.8 nTPM (vital, limit 1); lung: 4.6 nTPM (vital, limit 1); salivary gland: 4.6 nTPM (protected, limit 3); midbrain: 4.4 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 2); liver: 4.3 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); hippocampal formation: 4.1 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); pancreas: 3.7 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 3); choroid plexus: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: High (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,THAP2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000173464,True,compatible,,True,True,True,,0.35,0.3,0.249845,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RNASE11,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000173557,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.277273,0.00218659,0,4,partial,8.5,4.6,1.1,"choroid plexus: 8.5 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1)",,52,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CIMIP2C,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000173611,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.4103% (minimum 65%, Missing); adrenal gland: 46.8085% (minimum 75%, Missing); amygdala: 48.8889% (minimum 75%, Missing); basal ganglia: 39.2857% (minimum 75%, Missing); bone marrow: 44.0000% (minimum 75%, Missing); cerebellum: 41.5094% (minimum 75%, Missing); cerebral cortex: 24.1758% (minimum 75%, Missing); choroid plexus: 50.0000% (minimum 75%, Missing); colon: 55.0000% (minimum 70%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 62.8571% (minimum 70%, Missing); heart muscle: 62.8571% (minimum 75%, Missing); hippocampal formation: 48.8889% (minimum 75%, Missing); hypothalamus: 45.8333% (minimum 75%, Missing); kidney: 61.1111% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Missing); lung: 41.5094% (minimum 75%, Missing); lymph node: 44.0000% (minimum 70%, Missing); midbrain: 61.1111% (minimum 75%, Missing); pancreas: 56.4103% (minimum 75%, Missing); parathyroid gland: 59.4595% (minimum 70%, Missing); pituitary gland: 57.8947% (minimum 75%, Missing); rectum: 56.4103% (minimum 70%, Missing); retina: 23.4043% (minimum 75%, Missing); salivary gland: 62.8571% (minimum 70%, Missing); skeletal muscle: 57.8947% (minimum 75%, Missing); skin: 48.8889% (minimum 65%, Missing); small intestine: 59.4595% (minimum 75%, Missing); smooth muscle: 62.8571% (minimum 75%, Missing); spinal cord: 62.8571% (minimum 75%, Missing); spleen: 53.6585% (minimum 65%, Missing); stomach: 59.4595% (minimum 70%, Missing); thymus: 16.7939% (minimum 65%, Missing); thyroid gland: 55.0000% (minimum 65%, Missing); urinary bladder: 59.4595% (minimum 70%, Missing)",-0.482061,-0.26,-0.515957,0,4,partial,7.2,2.8,10.9,"thymus: 10.9 nTPM (manageable, limit 5); retina: 7.2 nTPM (vital, limit 1); cerebral cortex: 6.9 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); cerebellum: 3.1 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SCAI,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000173621,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 53.6232% (minimum 75%, Missing); basal ganglia: 60.9890% (minimum 75%, Missing); cerebellum: 35.6340% (minimum 75%, Missing); cerebral cortex: 48.0519% (minimum 75%, Missing); hippocampal formation: 53.7530% (minimum 75%, Missing); hypothalamus: 61.4958% (minimum 75%, Missing); kidney: 65.4867% (minimum 75%, Missing); midbrain: 72.5490% (minimum 75%, Missing); pituitary gland: 74.2475% (minimum 75%, Missing); spinal cord: 74.2475% (minimum 75%, Missing)",0.1,0.0326733,-0.39366,0,4,partial,40.1,14.4,14.8,"cerebellum: 40.1 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); amygdala: 19.2 nTPM (vital, limit 1); hippocampal formation: 19.1 nTPM (vital, limit 1); colon: 14.4 nTPM (protected, limit 12); basal ganglia: 14.2 nTPM (vital, limit 1); hypothalamus: 13.9 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 6); heart muscle: 11.9 nTPM (vital, limit 6); kidney: 11.7 nTPM (vital, limit 1); skeletal muscle: 9.3 nTPM (vital, limit 6); midbrain: 8.4 nTPM (vital, limit 1); lung: 8.1 nTPM (vital, limit 6); stomach: 8.1 nTPM (protected, limit 3); pituitary gland: 7.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1)",caudate / glial cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in tubules: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRFN4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000173627,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.29115,0.160569,0,80,unavailable,1.1,0.1,0,"lung: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,APOBEC4,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000173673,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"thymus: 12.5000% (minimum 65%, Missing)",-0.525,0.3,0.25,0,80,unavailable,0,0,0.7,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HES3,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000173699,True,compatible,,True,True,True,,0.35,0.3,0.248257,0,1,partial,0.3,0.2,0.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000173714,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"choroid plexus: 11.0868% (minimum 75%, Missing)",0.343684,0.292987,-0.639132,0,80,unavailable,1135.6,1,0.9,"choroid plexus: 1135.6 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,WFIKKN2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000173728,True,compatible,,True,True,True,,0.35,0.285507,0.25,0,80,unavailable,0,0.5,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPMIP3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000173769,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TOPAZ1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000173809,True,compatible,,True,True,True,,0.295578,0.285816,0.208621,0,80,unavailable,0.6,0.2,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TDRD12,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,True,True,True,True,gained,selectivity_revised
ENSG00000173818,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 74.0385% (minimum 75%, Missing); amygdala: 69.3694% (minimum 75%, Missing); basal ganglia: 64.1667% (minimum 75%, Missing); cerebellum: 66.9565% (minimum 75%, Missing); cerebral cortex: 65.6250% (minimum 75%, Missing); choroid plexus: 72.4138% (minimum 75%, Missing); colon: 68.5460% (minimum 70%, Missing); hippocampal formation: 69.3694% (minimum 75%, Missing); hypothalamus: 68.7500% (minimum 75%, Missing); kidney: 60.3133% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Missing); lung: 71.0769% (minimum 75%, Missing); midbrain: 73.8019% (minimum 75%, Missing); pancreas: 69.3694% (minimum 75%, Missing); pituitary gland: 71.9626% (minimum 75%, Missing); retina: 47.5309% (minimum 75%, Missing); salivary gland: 69.5783% (minimum 70%, Missing); skeletal muscle: 65.4391% (minimum 75%, Missing); skin: 61.4362% (minimum 65%, Missing); small intestine: 72.1875% (minimum 75%, Missing); spinal cord: 71.2963% (minimum 75%, Missing); spleen: 63.8122% (minimum 65%, Missing)",-0.0356383,-0.0145401,-0.274691,0,80,unavailable,25.5,10.6,14.5,"retina: 25.5 nTPM (vital, limit 1); kidney: 15.2 nTPM (vital, limit 1); liver: 14.7 nTPM (vital, limit 1); skin: 14.5 nTPM (manageable, limit 5); spleen: 13.1 nTPM (manageable, limit 5); basal ganglia: 12.9 nTPM (vital, limit 1); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); cerebellum: 11.4 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 3); hypothalamus: 10.5 nTPM (vital, limit 1); hippocampal formation: 10.2 nTPM (vital, limit 1); pancreas: 10.2 nTPM (vital, limit 1); amygdala: 10.2 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 3); lung: 9.4 nTPM (vital, limit 1); spinal cord: 9.3 nTPM (vital, limit 1); adipose tissue: 9.3 nTPM (manageable, limit 5); stomach: 9.2 nTPM (protected, limit 3); pituitary gland: 9 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 3); esophagus: 9 nTPM (protected, limit 3); small intestine: 8.9 nTPM (vital, limit 1); thyroid gland: 8.9 nTPM (manageable, limit 5); choroid plexus: 8.8 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 3); tongue: 5.3 nTPM (protected, limit 3); lymph node: 5.1 nTPM (protected, limit 3); thymus: 5.1 nTPM (manageable, limit 5); bone marrow: 4.9 nTPM (vital, limit 1); smooth muscle: 4.8 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENDOV,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000173838,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348506,0.3,0.132508,0,1,partial,17.8,1,0.2,"choroid plexus: 17.8 nTPM (vital, limit 1); pituitary gland: 12.3 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MARCHF10,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000173868,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.228841,0.269961,0.0925926,0,80,unavailable,18.7,3.1,13.8,"bone marrow: 18.7 nTPM (vital, limit 1); spleen: 13.8 nTPM (manageable, limit 5); cerebral cortex: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); small intestine: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PHOSPHO1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000173889,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.4879% (minimum 65%, Missing); adrenal gland: 62.3037% (minimum 75%, Missing); bone marrow: 19.1318% (minimum 75%, Missing); cerebellum: 70.0000% (minimum 75%, Missing); cerebral cortex: 67.2316% (minimum 75%, Missing); choroid plexus: 70.8333% (minimum 75%, Missing); colon: 54.0909% (minimum 70%, Missing); duodenum: 52.1930% (minimum 75%, Missing); esophagus: 49.7908% (minimum 70%, Missing); heart muscle: 60.4061% (minimum 75%, Missing); kidney: 55.8685% (minimum 75%, Missing); liver: 58.6207% (minimum 75%, Missing); lung: 55.8685% (minimum 75%, Missing); lymph node: 40.3390% (minimum 70%, Missing); pancreas: 52.1930% (minimum 75%, Missing); parathyroid gland: 44.9057% (minimum 70%, Missing); pituitary gland: 69.1860% (minimum 75%, Missing); rectum: 52.1930% (minimum 70%, Missing); retina: 22.6236% (minimum 75%, Missing); salivary gland: 58.0488% (minimum 70%, Missing); skeletal muscle: 58.6207% (minimum 75%, Missing); skin: 58.9109% (minimum 65%, Missing); small intestine: 49.7908% (minimum 75%, Missing); smooth muscle: 47.9839% (minimum 75%, Missing); spinal cord: 74.8428% (minimum 75%, Missing); spleen: 46.6667% (minimum 65%, Missing); stomach: 50.8547% (minimum 70%, Missing); thymus: 42.1986% (minimum 65%, Missing); thyroid gland: 42.5000% (minimum 65%, Missing); tongue: 47.0356% (minimum 70%, Missing); urinary bladder: 51.0730% (minimum 70%, Missing)",-0.228014,-0.29661,-0.558682,0,4,partial,50.3,17.6,16.3,"bone marrow: 50.3 nTPM (vital, limit 1); retina: 40.7 nTPM (vital, limit 1); lymph node: 17.6 nTPM (protected, limit 3); thymus: 16.3 nTPM (manageable, limit 5); thyroid gland: 16.1 nTPM (manageable, limit 5); parathyroid gland: 14.6 nTPM (protected, limit 3); spleen: 13.6 nTPM (manageable, limit 5); tongue: 13.4 nTPM (protected, limit 3); smooth muscle: 12.9 nTPM (vital, limit 1); small intestine: 12 nTPM (vital, limit 1); esophagus: 12 nTPM (protected, limit 3); stomach: 11.5 nTPM (protected, limit 3); urinary bladder: 11.4 nTPM (protected, limit 3); pancreas: 10.9 nTPM (vital, limit 1); rectum: 10.9 nTPM (protected, limit 3); duodenum: 10.9 nTPM (vital, limit 1); colon: 10.1 nTPM (protected, limit 3); kidney: 9.4 nTPM (vital, limit 1); lung: 9.4 nTPM (vital, limit 1); adipose tissue: 8.8 nTPM (manageable, limit 5); salivary gland: 8.6 nTPM (protected, limit 3); liver: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); heart muscle: 7.8 nTPM (vital, limit 1); adrenal gland: 7.2 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PHC3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000173894,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"thymus: 63.4518% (minimum 65%, Missing)",-0.0154822,0.053012,0.10034,0,1,partial,2.2,4.1,7.2,"thymus: 7.2 nTPM (manageable, limit 5); esophagus: 4.1 nTPM (protected, limit 3); bone marrow: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 2); lung: 1.2 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); lung / alveolar cells: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CBX2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000173908,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 5.8333% (minimum 65%, Missing)",-0.591667,0.3,0.25,0,5,partial,0,0,11.3,"skin: 11.3 nTPM (manageable, limit 5)",,68,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KRT28,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000173930,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 29.1667% (minimum 75%, Missing); duodenum: 62.5000% (minimum 75%, Missing); kidney: 8.0275% (minimum 75%, Missing); liver: 32.4074% (minimum 75%, Missing); lung: 31.5315% (minimum 75%, Missing); salivary gland: 64.8148% (minimum 70%, Missing); small intestine: 70.0000% (minimum 75%, Missing)",0.0362745,-0.0518519,-0.669725,0,80,unavailable,40.1,1.9,1.6,"kidney: 40.1 nTPM (vital, limit 1); bone marrow: 8.5 nTPM (vital, limit 1); lung: 7.6 nTPM (vital, limit 1); liver: 7.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLCO4C1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000173933,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.6604% (minimum 65%, Missing); adrenal gland: 48.1517% (minimum 75%, Missing); amygdala: 62.5702% (minimum 75%, Missing); basal ganglia: 62.2595% (minimum 75%, Missing); bone marrow: 43.6466% (minimum 75%, Missing); cerebellum: 47.6711% (minimum 75%, Missing); cerebral cortex: 62.7660% (minimum 75%, Missing); choroid plexus: 58.0776% (minimum 75%, Missing); colon: 51.9151% (minimum 70%, Missing); duodenum: 60.4217% (minimum 75%, Missing); esophagus: 50.7078% (minimum 70%, Missing); heart muscle: 57.8098% (minimum 75%, Missing); hippocampal formation: 63.4008% (minimum 75%, Missing); hypothalamus: 61.8754% (minimum 75%, Missing); kidney: 46.3066% (minimum 75%, Missing); liver: 55.5371% (minimum 75%, Missing); lung: 57.2162% (minimum 75%, Missing); lymph node: 51.3043% (minimum 70%, Missing); midbrain: 64.1715% (minimum 75%, Missing); pancreas: 47.2000% (minimum 75%, Missing); parathyroid gland: 57.3471% (minimum 70%, Missing); pituitary gland: 54.4813% (minimum 75%, Missing); rectum: 62.3756% (minimum 70%, Missing); retina: 58.3140% (minimum 75%, Missing); salivary gland: 53.6938% (minimum 70%, Missing); skeletal muscle: 51.8346% (minimum 75%, Missing); skin: 56.1276% (minimum 65%, Missing); small intestine: 55.2313% (minimum 75%, Missing); smooth muscle: 60.2041% (minimum 75%, Missing); spinal cord: 64.1715% (minimum 75%, Missing); spleen: 49.5064% (minimum 65%, Missing); stomach: 51.2257% (minimum 70%, Missing); thymus: 48.4307% (minimum 65%, Missing); thyroid gland: 54.6892% (minimum 65%, Missing); tongue: 59.0695% (minimum 70%, Missing); urinary bladder: 55.1705% (minimum 70%, Missing)",-0.165693,-0.192922,-0.313534,0,0,routine_complete,129.5,97.5,106.8,"bone marrow: 129.5 nTPM (vital, limit 1); kidney: 116.3 nTPM (vital, limit 1); pancreas: 112.2 nTPM (vital, limit 1); cerebellum: 110.1 nTPM (vital, limit 1); adrenal gland: 108 nTPM (vital, limit 1); thymus: 106.8 nTPM (manageable, limit 5); spleen: 102.3 nTPM (manageable, limit 5); esophagus: 97.5 nTPM (protected, limit 3); stomach: 95.5 nTPM (protected, limit 3); lymph node: 95.2 nTPM (protected, limit 3); skeletal muscle: 93.2 nTPM (vital, limit 1); colon: 92.9 nTPM (protected, limit 3); salivary gland: 86.5 nTPM (protected, limit 3); pituitary gland: 83.8 nTPM (vital, limit 1); thyroid gland: 83.1 nTPM (manageable, limit 5); urinary bladder: 81.5 nTPM (protected, limit 3); small intestine: 81.3 nTPM (vital, limit 1); liver: 80.3 nTPM (vital, limit 1); adipose tissue: 79.9 nTPM (manageable, limit 5); skin: 78.4 nTPM (manageable, limit 5); lung: 75 nTPM (vital, limit 1); parathyroid gland: 74.6 nTPM (protected, limit 3); heart muscle: 73.2 nTPM (vital, limit 1); choroid plexus: 72.4 nTPM (vital, limit 1); retina: 71.7 nTPM (vital, limit 1); tongue: 69.5 nTPM (protected, limit 3); smooth muscle: 66.3 nTPM (vital, limit 1); duodenum: 65.7 nTPM (vital, limit 1); hypothalamus: 61.8 nTPM (vital, limit 1); basal ganglia: 60.8 nTPM (vital, limit 1); rectum: 60.5 nTPM (protected, limit 3); amygdala: 60 nTPM (vital, limit 1); cerebral cortex: 59.5 nTPM (vital, limit 1); hippocampal formation: 57.9 nTPM (vital, limit 1); spinal cord: 56 nTPM (vital, limit 1); midbrain: 56 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RBM4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000173988,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 73.3333% (minimum 75%, Missing); midbrain: 68.7500% (minimum 75%, Missing); retina: 58.9286% (minimum 75%, Missing); spinal cord: 45.2055% (minimum 75%, Missing)",0.0833333,0.216667,-0.297945,0,80,unavailable,4,0.3,1.2,"spinal cord: 4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRRC63,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,False,False,False,False,unchanged,
ENSG00000174007,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 67.1329% (minimum 75%, Missing); basal ganglia: 60.7595% (minimum 75%, Missing); cerebellum: 72.7273% (minimum 75%, Missing); cerebral cortex: 60.0000% (minimum 75%, Missing); choroid plexus: 75.0000% (minimum 75%, Missing); hippocampal formation: 67.1329% (minimum 75%, Missing); hypothalamus: 64.4295% (minimum 75%, Missing); midbrain: 71.6418% (minimum 75%, Missing); pituitary gland: 72.1805% (minimum 75%, Missing); retina: 60.0000% (minimum 75%, Missing); thymus: 56.4706% (minimum 65%, Missing)",-0.0852941,0.142105,-0.15,0,5,partial,6.4,3.2,7.4,"thymus: 7.4 nTPM (manageable, limit 5); cerebral cortex: 6.4 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); pituitary gland: 3.7 nTPM (vital, limit 1); cerebellum: 3.6 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); hippocampus / glial cells: Medium (Enhanced); lung / macrophages: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CEP19,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000174015,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0.1,0.2,,,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CBY2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000174016,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TENT5D,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000174038,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.319359,0.277528,0.180481,0,80,unavailable,2.6,0.8,1.1,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA31G1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000174206,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 56.9892% (minimum 75%, Uncertain); amygdala: 65.4321% (minimum 75%, Missing); basal ganglia: 54.6392% (minimum 75%, Missing); cerebellum: 74.6479% (minimum 75%, Uncertain); cerebral cortex: 58.8889% (minimum 75%, Missing); choroid plexus: 74.6479% (minimum 75%, Missing); colon: 66.2500% (minimum 70%, Missing); duodenum: 63.8554% (minimum 75%, Missing); esophagus: 56.3830% (minimum 70%, Uncertain); heart muscle: 70.6667% (minimum 75%, Uncertain); hippocampal formation: 62.3529% (minimum 75%, Missing); hypothalamus: 64.6341% (minimum 75%, Missing); kidney: 50.0000% (minimum 75%, Missing); liver: 38.9706% (minimum 75%, Uncertain); lung: 66.2500% (minimum 75%, Missing); lymph node: 52.4752% (minimum 70%, Uncertain); midbrain: 61.6279% (minimum 75%, Missing); pancreas: 51.4563% (minimum 75%, Missing); parathyroid gland: 49.0741% (minimum 70%, Uncertain); pituitary gland: 67.9487% (minimum 75%, Missing); rectum: 63.8554% (minimum 70%, Missing); salivary gland: 65.4321% (minimum 70%, Uncertain); skeletal muscle: 55.2083% (minimum 75%, Uncertain); skin: 49.5327% (minimum 65%, Uncertain); small intestine: 68.8312% (minimum 75%, Missing); smooth muscle: 70.6667% (minimum 75%, Uncertain); spinal cord: 59.5506% (minimum 75%, Missing); spleen: 52.4752% (minimum 65%, Uncertain); stomach: 63.8554% (minimum 70%, Missing); thymus: 62.3529% (minimum 65%, Missing); thyroid gland: 49.5327% (minimum 65%, Missing); tongue: 63.0952% (minimum 70%, Missing); urinary bladder: 67.9487% (minimum 70%, Missing)",-0.154673,-0.209259,-0.360294,0,4,partial,8.3,5.5,5.4,"liver: 8.3 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 3); thyroid gland: 5.4 nTPM (manageable, limit 5); skin: 5.4 nTPM (manageable, limit 5); kidney: 5.3 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); lymph node: 4.8 nTPM (protected, limit 3); basal ganglia: 4.4 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); esophagus: 4.1 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KICS2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000174225,True,compatible,,True,True,True,,0.227193,0.243396,0.193396,0,80,unavailable,0.3,0.3,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ARL13A,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000174279,True,compatible,,True,True,True,,0.35,0.0631579,0.25,0,80,unavailable,0,0.9,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EVX2,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000174371,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 24.3363% (minimum 75%, Missing); colon: 63.9535% (minimum 70%, Missing); duodenum: 66.2651% (minimum 75%, Missing); esophagus: 69.6203% (minimum 70%, Missing); lymph node: 49.1071% (minimum 70%, Missing); rectum: 60.4396% (minimum 70%, Missing); small intestine: 69.6203% (minimum 75%, Missing); thymus: 33.7423% (minimum 65%, Missing)",-0.312577,-0.208929,-0.506637,0,80,unavailable,17.1,5.7,10.8,"bone marrow: 17.1 nTPM (vital, limit 1); thymus: 10.8 nTPM (manageable, limit 5); lymph node: 5.7 nTPM (protected, limit 3); rectum: 3.6 nTPM (protected, limit 3); colon: 3.1 nTPM (protected, limit 3); duodenum: 2.8 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EXO1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000174405,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.7381% (minimum 65%, Missing); adrenal gland: 54.4944% (minimum 75%, Missing); amygdala: 59.8765% (minimum 75%, Missing); basal ganglia: 58.7879% (minimum 75%, Missing); bone marrow: 69.7842% (minimum 75%, Missing); cerebellum: 59.5092% (minimum 75%, Missing); cerebral cortex: 45.1163% (minimum 75%, Missing); choroid plexus: 60.6250% (minimum 75%, Missing); colon: 63.3987% (minimum 70%, Missing); duodenum: 58.0838% (minimum 75%, Missing); esophagus: 69.2857% (minimum 70%, Missing); heart muscle: 59.8765% (minimum 75%, Missing); hippocampal formation: 55.7471% (minimum 75%, Missing); hypothalamus: 53.5912% (minimum 75%, Missing); kidney: 54.8023% (minimum 75%, Missing); liver: 43.4978% (minimum 75%, Missing); lung: 58.0838% (minimum 75%, Missing); lymph node: 46.8599% (minimum 70%, Missing); midbrain: 56.7251% (minimum 75%, Missing); pancreas: 65.5405% (minimum 75%, Missing); parathyroid gland: 46.6346% (minimum 70%, Missing); pituitary gland: 57.7381% (minimum 75%, Missing); rectum: 59.5092% (minimum 70%, Missing); retina: 27.6353% (minimum 75%, Missing); salivary gland: 68.7943% (minimum 70%, Missing); skeletal muscle: 58.0838% (minimum 75%, Missing); small intestine: 58.7879% (minimum 75%, Missing); smooth muscle: 59.1463% (minimum 75%, Missing); spinal cord: 53.2967% (minimum 75%, Missing); spleen: 54.1899% (minimum 65%, Missing); stomach: 55.7471% (minimum 70%, Missing); thymus: 30.9904% (minimum 65%, Missing); thyroid gland: 56.0694% (minimum 65%, Missing); tongue: 60.6250% (minimum 70%, Missing); urinary bladder: 58.7879% (minimum 70%, Missing)",-0.340096,-0.233654,-0.473647,0,8,partial,25.4,11.1,21.6,"retina: 25.4 nTPM (vital, limit 1); thymus: 21.6 nTPM (manageable, limit 5); liver: 12.6 nTPM (vital, limit 1); cerebral cortex: 11.8 nTPM (vital, limit 1); parathyroid gland: 11.1 nTPM (protected, limit 3); lymph node: 11 nTPM (protected, limit 3); spinal cord: 8.5 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); spleen: 8.2 nTPM (manageable, limit 5); adrenal gland: 8.1 nTPM (vital, limit 1); kidney: 8 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 3); hippocampal formation: 7.7 nTPM (vital, limit 1); thyroid gland: 7.6 nTPM (manageable, limit 5); midbrain: 7.4 nTPM (vital, limit 1); pituitary gland: 7.1 nTPM (vital, limit 1); adipose tissue: 7.1 nTPM (manageable, limit 5); lung: 7 nTPM (vital, limit 1); skeletal muscle: 7 nTPM (vital, limit 1); duodenum: 7 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); small intestine: 6.8 nTPM (vital, limit 1); urinary bladder: 6.8 nTPM (protected, limit 3); smooth muscle: 6.7 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 3); cerebellum: 6.6 nTPM (vital, limit 1); heart muscle: 6.5 nTPM (vital, limit 1); amygdala: 6.5 nTPM (vital, limit 1); choroid plexus: 6.3 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 3); colon: 5.6 nTPM (protected, limit 3); pancreas: 5.1 nTPM (vital, limit 1); skin: 5.1 nTPM (manageable, limit 5); salivary gland: 4.4 nTPM (protected, limit 3); esophagus: 4.3 nTPM (protected, limit 3); bone marrow: 4.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LIG4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000174446,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.9919% (minimum 65%, Uncertain); adrenal gland: 61.4089% (minimum 75%, Missing); amygdala: 46.7911% (minimum 75%, Missing); basal ganglia: 47.5682% (minimum 75%, Missing); bone marrow: 73.1752% (minimum 75%, Missing); cerebellum: 48.1971% (minimum 75%, Missing); cerebral cortex: 45.9336% (minimum 75%, Missing); choroid plexus: 47.7381% (minimum 75%, Missing); colon: 55.8496% (minimum 70%, Missing); duodenum: 72.5136% (minimum 75%, Missing); heart muscle: 49.4451% (minimum 75%, Missing); hippocampal formation: 55.0824% (minimum 75%, Missing); hypothalamus: 49.8137% (minimum 75%, Missing); kidney: 55.6172% (minimum 75%, Missing); liver: 54.1161% (minimum 75%, Missing); lung: 68.0815% (minimum 75%, Missing); lymph node: 63.4494% (minimum 70%, Missing); midbrain: 53.7534% (minimum 75%, Missing); pancreas: 64.8867% (minimum 75%, Missing); parathyroid gland: 55.7719% (minimum 70%, Missing); pituitary gland: 60.1199% (minimum 75%, Missing); rectum: 68.9003% (minimum 70%, Missing); retina: 59.2319% (minimum 75%, Missing); salivary gland: 69.1379% (minimum 70%, Missing); skeletal muscle: 40.8767% (minimum 75%, Missing); small intestine: 67.6223% (minimum 75%, Missing); smooth muscle: 67.2819% (minimum 75%, Uncertain); spinal cord: 61.3150% (minimum 75%, Missing); spleen: 64.3660% (minimum 65%, Missing); stomach: 64.0575% (minimum 70%, Missing); thyroid gland: 60.5740% (minimum 65%, Missing); tongue: 60.1199% (minimum 70%, Missing); urinary bladder: 60.2102% (minimum 70%, Missing)",-0.0442598,-0.142281,-0.341233,0,1,partial,58,31.8,26.1,"skeletal muscle: 58 nTPM (vital, limit 1); cerebral cortex: 47.2 nTPM (vital, limit 1); amygdala: 45.6 nTPM (vital, limit 1); basal ganglia: 44.2 nTPM (vital, limit 1); choroid plexus: 43.9 nTPM (vital, limit 1); cerebellum: 43.1 nTPM (vital, limit 1); heart muscle: 41 nTPM (vital, limit 1); hypothalamus: 40.4 nTPM (vital, limit 1); midbrain: 34.5 nTPM (vital, limit 1); liver: 34 nTPM (vital, limit 1); hippocampal formation: 32.7 nTPM (vital, limit 1); kidney: 32 nTPM (vital, limit 1); parathyroid gland: 31.8 nTPM (protected, limit 3); colon: 31.7 nTPM (protected, limit 3); retina: 27.6 nTPM (vital, limit 1); tongue: 26.6 nTPM (protected, limit 3); pituitary gland: 26.6 nTPM (vital, limit 1); urinary bladder: 26.5 nTPM (protected, limit 3); thyroid gland: 26.1 nTPM (manageable, limit 5); spinal cord: 25.3 nTPM (vital, limit 1); adrenal gland: 25.2 nTPM (vital, limit 1); lymph node: 23.1 nTPM (protected, limit 3); stomach: 22.5 nTPM (protected, limit 3); spleen: 22.2 nTPM (manageable, limit 5); pancreas: 21.7 nTPM (vital, limit 1); adipose tissue: 21.6 nTPM (manageable, limit 5); thymus: 20.7 nTPM (manageable, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); small intestine: 19.2 nTPM (vital, limit 1); lung: 18.8 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 3); salivary gland: 17.9 nTPM (protected, limit 3); esophagus: 15.3 nTPM (protected, limit 3); duodenum: 15.2 nTPM (vital, limit 1); skin: 14.7 nTPM (manageable, limit 5); bone marrow: 14.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SNAPC5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000174448,True,compatible,,True,True,True,,0.35,0.3,0.213855,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,STARD6,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000174450,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347996,0.297996,0.228389,0,80,unavailable,1.1,0.1,0.1,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GOLGA6L2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000174483,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 64.6778% (minimum 75%, Missing); amygdala: 59.9558% (minimum 75%, Missing); basal ganglia: 54.5272% (minimum 75%, Missing); cerebellum: 57.9060% (minimum 75%, Uncertain); cerebral cortex: 52.8265% (minimum 75%, Uncertain); choroid plexus: 57.4153% (minimum 75%, Missing); colon: 60.8989% (minimum 70%, Missing); heart muscle: 73.4417% (minimum 75%, Missing); hippocampal formation: 64.5238% (minimum 75%, Missing); hypothalamus: 62.0137% (minimum 75%, Missing); kidney: 53.7698% (minimum 75%, Missing); lung: 72.8495% (minimum 75%, Uncertain); midbrain: 68.2620% (minimum 75%, Missing); pancreas: 67.5810% (minimum 75%, Missing); parathyroid gland: 42.4765% (minimum 70%, Missing); pituitary gland: 60.8989% (minimum 75%, Missing); retina: 56.5762% (minimum 75%, Missing); salivary gland: 62.4424% (minimum 70%, Uncertain); small intestine: 74.8619% (minimum 75%, Missing); smooth muscle: 66.5848% (minimum 75%, Uncertain); spinal cord: 74.8619% (minimum 75%, Missing); stomach: 66.9136% (minimum 70%, Missing); thyroid gland: 50.6542% (minimum 65%, Missing); urinary bladder: 64.5238% (minimum 70%, Uncertain)",-0.143458,-0.275235,-0.221735,0,1,partial,24.2,36.7,26.4,"parathyroid gland: 36.7 nTPM (protected, limit 3); thyroid gland: 26.4 nTPM (manageable, limit 5); cerebral cortex: 24.2 nTPM (vital, limit 1); kidney: 23.3 nTPM (vital, limit 1); basal ganglia: 22.6 nTPM (vital, limit 1); retina: 20.8 nTPM (vital, limit 1); choroid plexus: 20.1 nTPM (vital, limit 1); cerebellum: 19.7 nTPM (vital, limit 1); amygdala: 18.1 nTPM (vital, limit 1); colon: 17.4 nTPM (protected, limit 3); pituitary gland: 17.4 nTPM (vital, limit 1); hypothalamus: 16.6 nTPM (vital, limit 1); salivary gland: 16.3 nTPM (protected, limit 3); urinary bladder: 14.9 nTPM (protected, limit 3); hippocampal formation: 14.9 nTPM (vital, limit 1); adrenal gland: 14.8 nTPM (vital, limit 1); smooth muscle: 13.6 nTPM (vital, limit 1); stomach: 13.4 nTPM (protected, limit 3); pancreas: 13 nTPM (vital, limit 1); midbrain: 12.6 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (manageable, limit 5); lung: 10.1 nTPM (vital, limit 1); heart muscle: 9.8 nTPM (vital, limit 1); skin: 9.3 nTPM (manageable, limit 5); small intestine: 9.1 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); esophagus: 8.7 nTPM (protected, limit 3); tongue: 7.9 nTPM (protected, limit 3); skeletal muscle: 7.8 nTPM (vital, limit 1); thymus: 7.7 nTPM (manageable, limit 5); rectum: 7.1 nTPM (protected, limit 3); liver: 6.8 nTPM (vital, limit 1); duodenum: 6.4 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5 nTPM (protected, limit 3); bone marrow: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BBS1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000174527,True,compatible,,True,True,True,,0.25,0.3,0,0,80,unavailable,0.3,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MYO1H,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000174562,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.8947% (minimum 75%, Uncertain); colon: 33.3333% (minimum 70%, Uncertain); rectum: 55.0000% (minimum 70%, Uncertain); salivary gland: 22.0000% (minimum 70%, Uncertain); thyroid gland: 61.1111% (minimum 65%, Uncertain)",-0.0388889,-0.48,-0.171053,0,0,routine_complete,0.8,3.9,0.7,"salivary gland: 3.9 nTPM (protected, limit 3)",,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KLK15,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000174667,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 25.0000% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); retina: 25.0000% (minimum 75%, Missing); skeletal muscle: 50.0000% (minimum 75%, Missing); skin: 50.0000% (minimum 65%, Missing); small intestine: 50.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing)",-0.15,0.3,-0.5,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR7D4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000174776,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 49.1620% (minimum 75%, Missing); small intestine: 67.1756% (minimum 75%, Missing)",0.306522,0.207216,-0.25838,0,80,unavailable,9.1,0.9,0.4,"choroid plexus: 9.1 nTPM (vital, limit 1); small intestine: 4.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,WDR49,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000174788,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 48.4701% (minimum 75%, Missing)",0.29143,0.173701,-0.265299,0,80,unavailable,116.2,15.8,6.8,"cerebellum: 116.2 nTPM (vital, limit 1); retina: 32.3 nTPM (vital, limit 1); salivary gland: 15.8 nTPM (protected, limit 3); kidney: 7.8 nTPM (vital, limit 1); skin: 6.8 nTPM (manageable, limit 5); hypothalamus: 6.6 nTPM (vital, limit 1); thyroid gland: 5.5 nTPM (manageable, limit 5); spinal cord: 5.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCP2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000174796,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.5439% (minimum 75%, Missing); bone marrow: 65.0704% (minimum 75%, Missing); cerebellum: 66.9565% (minimum 75%, Missing); cerebral cortex: 65.0704% (minimum 75%, Missing); duodenum: 65.6250% (minimum 75%, Missing); heart muscle: 62.2642% (minimum 75%, Missing); kidney: 70.6422% (minimum 75%, Missing); liver: 65.6250% (minimum 75%, Missing); lung: 71.7391% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); pancreas: 73.5669% (minimum 75%, Missing); parathyroid gland: 66.0000% (minimum 70%, Missing); pituitary gland: 71.5170% (minimum 75%, Missing); rectum: 66.9565% (minimum 70%, Missing); retina: 52.3810% (minimum 75%, Missing); salivary gland: 63.9889% (minimum 70%, Missing); skeletal muscle: 60.6299% (minimum 75%, Missing); skin: 58.7786% (minimum 65%, Missing); small intestine: 64.5251% (minimum 75%, Missing); smooth muscle: 69.1617% (minimum 75%, Missing); spinal cord: 71.7391% (minimum 75%, Missing); stomach: 68.5460% (minimum 70%, Missing); thyroid gland: 60.6299% (minimum 65%, Missing); tongue: 63.9889% (minimum 70%, Missing)",-0.0622137,-0.1,-0.22619,0,80,unavailable,21,15.4,16.2,"retina: 21 nTPM (vital, limit 1); skin: 16.2 nTPM (manageable, limit 5); lymph node: 15.4 nTPM (protected, limit 3); skeletal muscle: 15 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); heart muscle: 14 nTPM (vital, limit 1); salivary gland: 13 nTPM (protected, limit 3); tongue: 13 nTPM (protected, limit 3); small intestine: 12.7 nTPM (vital, limit 1); cerebral cortex: 12.4 nTPM (vital, limit 1); bone marrow: 12.4 nTPM (vital, limit 1); spleen: 12.3 nTPM (manageable, limit 5); duodenum: 12.1 nTPM (vital, limit 1); liver: 12.1 nTPM (vital, limit 1); parathyroid gland: 11.9 nTPM (protected, limit 3); cerebellum: 11.4 nTPM (vital, limit 1); rectum: 11.4 nTPM (protected, limit 3); adrenal gland: 11.1 nTPM (vital, limit 1); stomach: 10.6 nTPM (protected, limit 3); smooth muscle: 10.3 nTPM (vital, limit 1); adipose tissue: 9.6 nTPM (manageable, limit 5); colon: 9.6 nTPM (protected, limit 3); kidney: 9.6 nTPM (vital, limit 1); esophagus: 9.4 nTPM (protected, limit 3); pituitary gland: 9.2 nTPM (vital, limit 1); spinal cord: 9.1 nTPM (vital, limit 1); lung: 9.1 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); urinary bladder: 8.9 nTPM (protected, limit 3); pancreas: 8.3 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); choroid plexus: 6.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); hippocampal formation: 6.1 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,THAP6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000174886,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.4670% (minimum 65%, Missing); adrenal gland: 34.7028% (minimum 75%, Missing); amygdala: 42.7055% (minimum 75%, Missing); basal ganglia: 46.9055% (minimum 75%, Missing); bone marrow: 58.6691% (minimum 75%, Missing); cerebellum: 56.1533% (minimum 75%, Missing); cerebral cortex: 45.3856% (minimum 75%, Missing); choroid plexus: 44.9067% (minimum 75%, Missing); colon: 42.3136% (minimum 70%, Missing); duodenum: 64.6320% (minimum 75%, Missing); esophagus: 44.5541% (minimum 70%, Missing); heart muscle: 24.9746% (minimum 75%, Missing); hippocampal formation: 46.9951% (minimum 75%, Missing); hypothalamus: 44.5900% (minimum 75%, Missing); kidney: 43.9523% (minimum 75%, Missing); liver: 37.3502% (minimum 75%, Missing); lung: 59.5373% (minimum 75%, Missing); lymph node: 60.9810% (minimum 70%, Missing); midbrain: 42.8461% (minimum 75%, Missing); pancreas: 52.5528% (minimum 75%, Missing); parathyroid gland: 62.3556% (minimum 70%, Missing); pituitary gland: 52.4656% (minimum 75%, Missing); salivary gland: 49.6857% (minimum 70%, Missing); skeletal muscle: 35.0214% (minimum 75%, Missing); skin: 54.8995% (minimum 65%, Missing); small intestine: 55.1046% (minimum 75%, Missing); smooth muscle: 71.9909% (minimum 75%, Missing); spinal cord: 46.1715% (minimum 75%, Missing); spleen: 53.5835% (minimum 65%, Missing); stomach: 47.6734% (minimum 70%, Missing); thyroid gland: 54.7095% (minimum 65%, Missing); tongue: 41.1033% (minimum 70%, Missing); urinary bladder: 52.2180% (minimum 70%, Missing)",-0.11533,-0.288967,-0.500254,0,80,unavailable,664.8,317.1,192.6,"heart muscle: 664.8 nTPM (vital, limit 1); adrenal gland: 416.4 nTPM (vital, limit 1); skeletal muscle: 410.6 nTPM (vital, limit 1); liver: 371.2 nTPM (vital, limit 1); tongue: 317.1 nTPM (protected, limit 3); colon: 301.7 nTPM (protected, limit 3); amygdala: 296.9 nTPM (vital, limit 1); midbrain: 295.2 nTPM (vital, limit 1); kidney: 282.2 nTPM (vital, limit 1); esophagus: 275.4 nTPM (protected, limit 3); hypothalamus: 275 nTPM (vital, limit 1); choroid plexus: 271.5 nTPM (vital, limit 1); cerebral cortex: 266.3 nTPM (vital, limit 1); spinal cord: 258 nTPM (vital, limit 1); basal ganglia: 250.5 nTPM (vital, limit 1); hippocampal formation: 249.6 nTPM (vital, limit 1); stomach: 242.9 nTPM (protected, limit 3); salivary gland: 224.1 nTPM (protected, limit 3); urinary bladder: 202.5 nTPM (protected, limit 3); pituitary gland: 200.5 nTPM (vital, limit 1); pancreas: 199.8 nTPM (vital, limit 1); adipose tissue: 192.6 nTPM (manageable, limit 5); spleen: 191.7 nTPM (manageable, limit 5); thyroid gland: 183.2 nTPM (manageable, limit 5); skin: 181.8 nTPM (manageable, limit 5); small intestine: 180.3 nTPM (vital, limit 1); cerebellum: 172.8 nTPM (vital, limit 1); bone marrow: 155.9 nTPM (vital, limit 1); lung: 150.4 nTPM (vital, limit 1); lymph node: 141.6 nTPM (protected, limit 3); parathyroid gland: 133.6 nTPM (protected, limit 3); duodenum: 121.1 nTPM (vital, limit 1); thymus: 117.3 nTPM (manageable, limit 5); smooth muscle: 86.1 nTPM (vital, limit 1); rectum: 54.2 nTPM (protected, limit 3); retina: 30.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NDUFA11,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000174898,True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CATSPERD,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000175018,True,compatible,,True,True,True,,0.338593,0.292366,0.234848,0,80,unavailable,0.4,0.2,0.3,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX36,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000175073,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.5556% (minimum 65%, Missing); adrenal gland: 61.1111% (minimum 75%, Missing); amygdala: 66.2651% (minimum 75%, Missing); basal ganglia: 65.4762% (minimum 75%, Missing); bone marrow: 21.5686% (minimum 75%, Missing); cerebellum: 65.4762% (minimum 75%, Missing); cerebral cortex: 49.1071% (minimum 75%, Missing); colon: 56.1224% (minimum 70%, Missing); duodenum: 59.7826% (minimum 75%, Missing); esophagus: 62.5000% (minimum 70%, Missing); heart muscle: 66.2651% (minimum 75%, Missing); hippocampal formation: 64.7059% (minimum 75%, Missing); hypothalamus: 66.2651% (minimum 75%, Missing); kidney: 56.7010% (minimum 75%, Missing); liver: 44.7154% (minimum 75%, Missing); lung: 57.8947% (minimum 75%, Missing); lymph node: 39.8551% (minimum 70%, Missing); midbrain: 66.2651% (minimum 75%, Missing); pancreas: 58.5106% (minimum 75%, Missing); parathyroid gland: 50.4587% (minimum 70%, Missing); rectum: 58.5106% (minimum 70%, Missing); retina: 55.5556% (minimum 75%, Missing); salivary gland: 57.2917% (minimum 70%, Missing); skeletal muscle: 51.8868% (minimum 75%, Missing); skin: 63.2184% (minimum 65%, Missing); small intestine: 61.1111% (minimum 75%, Missing); smooth muscle: 63.2184% (minimum 75%, Missing); spinal cord: 67.9012% (minimum 75%, Missing); spleen: 39.0071% (minimum 65%, Missing); stomach: 55.5556% (minimum 70%, Missing); thymus: 51.4019% (minimum 65%, Missing); thyroid gland: 57.2917% (minimum 65%, Missing); tongue: 51.8868% (minimum 70%, Missing); urinary bladder: 57.8947% (minimum 70%, Missing)",-0.259929,-0.301449,-0.534314,0,80,unavailable,20,8.3,8.6,"bone marrow: 20 nTPM (vital, limit 1); spleen: 8.6 nTPM (manageable, limit 5); lymph node: 8.3 nTPM (protected, limit 3); liver: 6.8 nTPM (vital, limit 1); cerebral cortex: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.4 nTPM (protected, limit 3); thymus: 5.2 nTPM (manageable, limit 5); tongue: 5.1 nTPM (protected, limit 3); skeletal muscle: 5.1 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); retina: 4.4 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 3); kidney: 4.2 nTPM (vital, limit 1); salivary gland: 4.1 nTPM (protected, limit 3); lung: 4 nTPM (vital, limit 1); urinary bladder: 4 nTPM (protected, limit 3); rectum: 3.9 nTPM (protected, limit 3); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1); adrenal gland: 3.5 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); esophagus: 3.3 nTPM (protected, limit 3); smooth muscle: 3.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,VCPIP1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000175097,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 41.6667% (minimum 75%, Missing); thymus: 0.6784% (minimum 65%, Missing); thyroid gland: 4.1667% (minimum 65%, Missing)",-0.643216,0.3,-0.333333,0,80,unavailable,1.4,0,146.4,"thymus: 146.4 nTPM (manageable, limit 5); thyroid gland: 23 nTPM (manageable, limit 5); bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RAG2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000175106,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 57.0470% (minimum 75%, Uncertain); amygdala: 73.2759% (minimum 75%, Missing); basal ganglia: 74.5614% (minimum 75%, Missing); bone marrow: 44.2708% (minimum 75%, Missing); cerebellum: 68.5484% (minimum 75%, Missing); choroid plexus: 56.2914% (minimum 75%, Missing); esophagus: 59.8592% (minimum 70%, Missing); heart muscle: 68.5484% (minimum 75%, Missing); hippocampal formation: 70.2479% (minimum 75%, Missing); hypothalamus: 69.6721% (minimum 75%, Missing); kidney: 57.8231% (minimum 75%, Missing); liver: 69.1057% (minimum 75%, Uncertain); lung: 65.8915% (minimum 75%, Missing); midbrain: 69.1057% (minimum 75%, Missing); pancreas: 62.9630% (minimum 75%, Missing); pituitary gland: 46.4481% (minimum 75%, Missing); retina: 68.0000% (minimum 75%, Missing); salivary gland: 59.4406% (minimum 70%, Missing); skeletal muscle: 74.5614% (minimum 75%, Uncertain); small intestine: 69.6721% (minimum 75%, Missing); spinal cord: 63.4328% (minimum 75%, Missing); spleen: 64.8855% (minimum 65%, Uncertain); stomach: 69.6721% (minimum 70%, Missing); thyroid gland: 56.2914% (minimum 65%, Missing); urinary bladder: 69.1057% (minimum 70%, Missing)",-0.0870861,-0.105594,-0.307292,0,1,partial,10.7,5.8,6.6,"bone marrow: 10.7 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); choroid plexus: 6.6 nTPM (vital, limit 1); adrenal gland: 6.4 nTPM (vital, limit 1); kidney: 6.2 nTPM (vital, limit 1); salivary gland: 5.8 nTPM (protected, limit 3); esophagus: 5.7 nTPM (protected, limit 3); pancreas: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); retina: 4 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1); heart muscle: 3.9 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); liver: 3.8 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 3); hypothalamus: 3.7 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 3); parathyroid gland: 3.6 nTPM (protected, limit 3); hippocampal formation: 3.6 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); amygdala: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TVP23C,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000175175,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 55.0847% (minimum 75%, Missing); amygdala: 65.0000% (minimum 75%, Missing); cerebellum: 50.3876% (minimum 75%, Missing); cerebral cortex: 34.9462% (minimum 75%, Missing); hippocampal formation: 38.6905% (minimum 75%, Missing); hypothalamus: 54.1667% (minimum 75%, Missing); midbrain: 65.6566% (minimum 75%, Missing); retina: 23.1317% (minimum 75%, Missing); spinal cord: 74.7126% (minimum 75%, Missing)",0.320149,0.255882,-0.518683,0,1,partial,21.6,0.4,0.2,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 12.1 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); cerebellum: 6.4 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); adrenal gland: 5.3 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); parathyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PPM1E,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000175202,True,compatible,,True,True,True,,0.295946,0.3,0.25,0,80,unavailable,0,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HIGD2B,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding,False,True,True,True,True,gained,selectivity_revised
ENSG00000175294,True,compatible,,True,True,True,,0.332456,0.294083,0.221098,0,80,unavailable,0.5,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CATSPER1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000175305,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 27.8656% (minimum 75%, Missing); cerebral cortex: 65.8879% (minimum 75%, Missing); lymph node: 57.0850% (minimum 70%, Missing); midbrain: 72.3077% (minimum 75%, Missing); retina: 73.8220% (minimum 75%, Missing); spinal cord: 44.6203% (minimum 75%, Missing); thymus: 48.9583% (minimum 65%, Missing)",-0.160417,-0.12915,-0.471344,0,1,partial,36.5,10.6,14.7,"bone marrow: 36.5 nTPM (vital, limit 1); spinal cord: 17.5 nTPM (vital, limit 1); thymus: 14.7 nTPM (manageable, limit 5); lymph node: 10.6 nTPM (protected, limit 3); cerebral cortex: 7.3 nTPM (vital, limit 1); skin: 5.7 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 3); midbrain: 5.4 nTPM (vital, limit 1); colon: 5.3 nTPM (protected, limit 3); retina: 5 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 3); small intestine: 4.2 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); stomach: 3.9 nTPM (protected, limit 3); duodenum: 3.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Medium (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCNE2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000175344,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 24.2424% (minimum 75%, Missing); amygdala: 70.5882% (minimum 75%, Missing); bone marrow: 72.7273% (minimum 75%, Missing); cerebral cortex: 58.5366% (minimum 75%, Missing); choroid plexus: 38.7097% (minimum 75%, Missing); colon: 63.1579% (minimum 70%, Missing); duodenum: 35.8209% (minimum 75%, Missing); hippocampal formation: 75.0000% (minimum 75%, Missing); hypothalamus: 55.8140% (minimum 75%, Missing); midbrain: 75.0000% (minimum 75%, Missing); pancreas: 51.0638% (minimum 75%, Missing); parathyroid gland: 27.9070% (minimum 70%, Missing); pituitary gland: 70.5882% (minimum 75%, Missing); rectum: 52.1739% (minimum 70%, Missing); retina: 48.9796% (minimum 75%, Missing); small intestine: 20.3390% (minimum 75%, Missing); stomach: 27.2727% (minimum 70%, Missing); thyroid gland: 53.3333% (minimum 65%, Missing); urinary bladder: 63.1579% (minimum 70%, Missing)",-0.116667,-0.427273,-0.54661,0,8,partial,9.4,6.4,2.1,"small intestine: 9.4 nTPM (vital, limit 1); adrenal gland: 7.5 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 3); parathyroid gland: 6.2 nTPM (protected, limit 3); duodenum: 4.3 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); liver / hepatocytes: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Medium (Enhanced); rectum / peripheral nerve/ganglion: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); soft tissue 2 / chondrocytes: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),76,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CHRNA7,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000175449,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 40.3390% (minimum 75%, Uncertain); skeletal muscle: 72.1212% (minimum 75%, Missing)",0.0668675,0.104054,-0.34661,0,1,partial,17.6,2.9,4.7,"bone marrow: 17.6 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); spinal cord: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RFESD,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000175513,True,compatible,,True,True,True,,0.329798,0.3,0.182692,0,80,unavailable,0.7,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TSGA10IP,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000175518,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.306656,0.277848,0.209627,0,80,unavailable,1.3,0.7,1.4,"kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,UBQLNL,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000175520,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,UBQLN3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000175536,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"kidney: 73.1707% (minimum 75%, Missing); skeletal muscle: 60.6061% (minimum 75%, Missing); tongue: 63.8298% (minimum 70%, Missing)",0.155369,-0.0617021,-0.143939,0,9,partial,7.8,6.8,2.9,"skeletal muscle: 7.8 nTPM (vital, limit 1); tongue: 6.8 nTPM (protected, limit 3); kidney: 4.4 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1); small intestine: 3.5 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LIPT2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000175548,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 59.5238% (minimum 75%, Missing); bone marrow: 54.3478% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); duodenum: 67.5676% (minimum 75%, Missing); heart muscle: 70.4225% (minimum 75%, Missing); kidney: 61.7284% (minimum 75%, Missing); liver: 58.1395% (minimum 75%, Missing); lung: 67.5676% (minimum 75%, Missing); lymph node: 52.6316% (minimum 70%, Missing); pancreas: 64.1026% (minimum 75%, Missing); parathyroid gland: 58.8235% (minimum 70%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 36.2319% (minimum 75%, Missing); salivary gland: 64.9351% (minimum 70%, Missing); skin: 54.3478% (minimum 65%, Missing); small intestine: 66.6667% (minimum 75%, Missing); smooth muscle: 67.5676% (minimum 75%, Missing); spleen: 52.6316% (minimum 65%, Missing); stomach: 58.1395% (minimum 70%, Missing); thymus: 56.1798% (minimum 65%, Missing); thyroid gland: 55.5556% (minimum 65%, Missing); tongue: 68.4932% (minimum 70%, Missing)",-0.123684,-0.173684,-0.387681,0,1,partial,8.8,4.5,4.5,"retina: 8.8 nTPM (vital, limit 1); lymph node: 4.5 nTPM (protected, limit 3); bone marrow: 4.2 nTPM (vital, limit 1); liver: 3.6 nTPM (vital, limit 1); stomach: 3.6 nTPM (protected, limit 3); parathyroid gland: 3.5 nTPM (protected, limit 3); adrenal gland: 3.4 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ALG10B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000175646,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.249862,0,1,partial,5.6,2.3,4.2,"pituitary gland: 1.9 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRM1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000175664,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 64.3077% (minimum 75%, Missing)",0.345238,0.3,-0.106923,0,80,unavailable,11.6,0,0.1,"choroid plexus: 11.6 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX26,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000175699,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.228571,0.136364,0,80,unavailable,1,0.6,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,CCDC197,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000175718,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RBMXL3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000175764,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.0058% (minimum 75%, Missing); amygdala: 57.5610% (minimum 75%, Missing); basal ganglia: 58.7065% (minimum 75%, Missing); cerebellum: 65.9218% (minimum 75%, Missing); cerebral cortex: 52.6786% (minimum 75%, Missing); choroid plexus: 70.2381% (minimum 75%, Missing); colon: 54.3779% (minimum 70%, Missing); esophagus: 63.1016% (minimum 70%, Missing); heart muscle: 70.2381% (minimum 75%, Missing); hippocampal formation: 51.3043% (minimum 75%, Missing); hypothalamus: 62.7660% (minimum 75%, Missing); liver: 69.4118% (minimum 75%, Missing); midbrain: 47.3896% (minimum 75%, Missing); pancreas: 70.2381% (minimum 75%, Missing); retina: 64.1304% (minimum 75%, Missing); skeletal muscle: 30.8094% (minimum 75%, Missing); smooth muscle: 55.6604% (minimum 75%, Missing); spinal cord: 35.1190% (minimum 75%, Missing); tongue: 58.1281% (minimum 70%, Missing); urinary bladder: 68.2081% (minimum 70%, Missing)",0.0739264,-0.156221,-0.441906,0,2,partial,26.5,9.9,4.5,"skeletal muscle: 26.5 nTPM (vital, limit 1); spinal cord: 21.8 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hippocampal formation: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.6 nTPM (vital, limit 1); colon: 9.9 nTPM (protected, limit 3); smooth muscle: 9.4 nTPM (vital, limit 1); amygdala: 8.7 nTPM (vital, limit 1); tongue: 8.5 nTPM (protected, limit 3); basal ganglia: 8.3 nTPM (vital, limit 1); hypothalamus: 7 nTPM (vital, limit 1); esophagus: 6.9 nTPM (protected, limit 3); retina: 6.6 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); urinary bladder: 5.5 nTPM (protected, limit 3); adrenal gland: 5.3 nTPM (vital, limit 1); liver: 5.2 nTPM (vital, limit 1); pancreas: 5 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 3); parathyroid gland: 4.5 nTPM (protected, limit 4); stomach: 4.1 nTPM (protected, limit 3); rectum: 4 nTPM (protected, limit 3); lung: 3.9 nTPM (vital, limit 2); small intestine: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TTLL11,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000175787,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.1975% (minimum 65%, Missing); adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 59.7701% (minimum 75%, Missing); basal ganglia: 56.5217% (minimum 75%, Missing); bone marrow: 63.4146% (minimum 75%, Missing); cerebellum: 46.8468% (minimum 75%, Missing); cerebral cortex: 49.0566% (minimum 75%, Missing); choroid plexus: 73.2394% (minimum 75%, Missing); colon: 55.3191% (minimum 70%, Missing); duodenum: 65.0000% (minimum 75%, Missing); esophagus: 67.5325% (minimum 70%, Missing); heart muscle: 67.5325% (minimum 75%, Missing); hippocampal formation: 52.5253% (minimum 75%, Missing); hypothalamus: 62.6506% (minimum 75%, Missing); kidney: 59.0909% (minimum 75%, Missing); liver: 71.2329% (minimum 75%, Missing); lung: 62.6506% (minimum 75%, Missing); lymph node: 47.2727% (minimum 70%, Missing); midbrain: 62.6506% (minimum 75%, Missing); pancreas: 61.9048% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); rectum: 50.0000% (minimum 70%, Missing); retina: 57.1429% (minimum 75%, Missing); salivary gland: 57.7778% (minimum 70%, Missing); skeletal muscle: 56.5217% (minimum 75%, Missing); skin: 51.4851% (minimum 65%, Missing); small intestine: 48.5981% (minimum 75%, Missing); smooth muscle: 65.8228% (minimum 75%, Missing); spinal cord: 59.7701% (minimum 75%, Missing); spleen: 46.8468% (minimum 65%, Missing); stomach: 57.1429% (minimum 70%, Missing); thymus: 59.0909% (minimum 65%, Missing); thyroid gland: 52.5253% (minimum 65%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",-0.181532,-0.227273,-0.281532,0,3,partial,5.9,5.8,5.9,"cerebellum: 5.9 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 3); small intestine: 5.5 nTPM (vital, limit 1); cerebral cortex: 5.4 nTPM (vital, limit 1); rectum: 5.2 nTPM (protected, limit 3); hippocampal formation: 4.7 nTPM (vital, limit 1); colon: 4.2 nTPM (protected, limit 3); skeletal muscle: 4 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); retina: 3.9 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 3); stomach: 3.9 nTPM (protected, limit 3); salivary gland: 3.8 nTPM (protected, limit 3); kidney: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); spinal cord: 3.5 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF169,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000175809,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CBLL2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000175820,True,compatible,,True,True,True,,0.35,0.3,0.238506,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC168,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,True,True,True,True,gained,selectivity_revised
ENSG00000175877,True,compatible,,True,True,True,,0.35,0.3,0.246037,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TMEM270,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000176020,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 68.0000% (minimum 75%, Missing); basal ganglia: 73.9130% (minimum 75%, Missing); bone marrow: 53.1250% (minimum 75%, Missing); cerebellum: 68.0000% (minimum 75%, Missing); esophagus: 65.3846% (minimum 70%, Missing); heart muscle: 65.3846% (minimum 75%, Missing); hypothalamus: 62.9630% (minimum 75%, Missing); kidney: 73.9130% (minimum 75%, Missing); liver: 48.5714% (minimum 75%, Missing); lung: 65.3846% (minimum 75%, Missing); pancreas: 53.1250% (minimum 75%, Missing); pituitary gland: 36.1702% (minimum 75%, Missing); salivary gland: 65.3846% (minimum 70%, Missing); skeletal muscle: 34.0000% (minimum 75%, Missing); skin: 36.9565% (minimum 65%, Missing); small intestine: 70.8333% (minimum 75%, Missing); spinal cord: 73.9130% (minimum 75%, Missing); spleen: 62.9630% (minimum 65%, Missing); stomach: 62.9630% (minimum 70%, Missing)",-0.280435,-0.0703704,-0.41,0,80,unavailable,3.3,1,2.9,"skeletal muscle: 3.3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AMIGO3,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000176040,True,compatible,,True,True,True,,0.216667,0.166667,0.116667,0,80,unavailable,0.2,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TMPRSS7,current_adaptive,True,False,True,False,10.1038/ncomms10499,Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000176083,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.316019,0.19038,0.195368,0,2,partial,4.6,9.8,2.8,"salivary gland: 9.8 nTPM (protected, limit 3); lung: 4.6 nTPM (vital, limit 1); stomach: 3.3 nTPM (protected, limit 3); bone marrow: 1.9 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF683,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000176148,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.7132% (minimum 65%, Missing); adrenal gland: 58.1197% (minimum 75%, Missing); amygdala: 58.6207% (minimum 75%, Missing); basal ganglia: 64.1509% (minimum 75%, Missing); bone marrow: 48.2270% (minimum 75%, Missing); cerebellum: 56.1983% (minimum 75%, Missing); cerebral cortex: 35.7895% (minimum 75%, Missing); choroid plexus: 64.7619% (minimum 75%, Missing); colon: 50.3704% (minimum 70%, Missing); duodenum: 53.5433% (minimum 75%, Missing); esophagus: 59.1304% (minimum 70%, Missing); heart muscle: 60.1770% (minimum 70%, Approved); hippocampal formation: 56.1983% (minimum 75%, Missing); hypothalamus: 55.2846% (minimum 75%, Missing); kidney: 54.4000% (minimum 75%, Missing); liver: 63.5514% (minimum 75%, Missing); lung: 60.1770% (minimum 75%, Missing); lymph node: 58.6207% (minimum 70%, Missing); midbrain: 51.9084% (minimum 75%, Missing); pancreas: 55.2846% (minimum 75%, Missing); parathyroid gland: 63.5514% (minimum 70%, Missing); pituitary gland: 58.1197% (minimum 75%, Missing); rectum: 49.2754% (minimum 70%, Missing); retina: 53.9683% (minimum 75%, Missing); salivary gland: 58.6207% (minimum 70%, Missing); skin: 56.6667% (minimum 65%, Missing); small intestine: 44.1558% (minimum 75%, Missing); smooth muscle: 44.7368% (minimum 75%, Missing); spinal cord: 51.1278% (minimum 75%, Missing); spleen: 56.6667% (minimum 65%, Missing); stomach: 62.3853% (minimum 70%, Missing); thymus: 47.8873% (minimum 65%, Missing); tongue: 63.5514% (minimum 70%, Missing); urinary bladder: 54.8387% (minimum 70%, Missing)",-0.171127,-0.207246,-0.392105,0,10,partial,12.2,7,7.4,"cerebral cortex: 12.2 nTPM (vital, limit 1); small intestine: 8.6 nTPM (vital, limit 1); smooth muscle: 8.4 nTPM (vital, limit 1); thymus: 7.4 nTPM (manageable, limit 5); bone marrow: 7.3 nTPM (vital, limit 1); rectum: 7 nTPM (protected, limit 3); colon: 6.7 nTPM (protected, limit 3); spinal cord: 6.5 nTPM (vital, limit 1); midbrain: 6.3 nTPM (vital, limit 1); adipose tissue: 6.1 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 3); hypothalamus: 5.5 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); spleen: 5.2 nTPM (manageable, limit 5); adrenal gland: 4.9 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 3); lymph node: 4.8 nTPM (protected, limit 3); esophagus: 4.7 nTPM (protected, limit 3); heart muscle: 4.5 nTPM (vital, limit 2); lung: 4.5 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 3); liver: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 3); tongue: 3.9 nTPM (protected, limit 3); basal ganglia: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TCP11L1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000176160,True,compatible,,True,True,True,,0.333368,0.3,0.24789,0,2,partial,0.4,1.1,0.8,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HSF5,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000176165,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 20.2128% (minimum 75%, Missing); basal ganglia: 16.8889% (minimum 75%, Missing); cerebral cortex: 15.5738% (minimum 75%, Missing); hippocampal formation: 19.7917% (minimum 75%, Missing); hypothalamus: 62.2951% (minimum 75%, Missing); pituitary gland: 58.4615% (minimum 75%, Missing); thymus: 55.8824% (minimum 65%, Missing)",-0.0911765,0.183721,-0.594262,0,80,unavailable,20.6,0.5,3,"cerebral cortex: 20.6 nTPM (vital, limit 1); basal ganglia: 18.7 nTPM (vital, limit 1); hippocampal formation: 15.4 nTPM (vital, limit 1); amygdala: 15 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FOXG1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000176177,True,compatible,,True,True,True,,0.241667,0.246903,0.172414,0,80,unavailable,0.9,0.6,1.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENTHD1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000176198,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR11H4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000176208,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 13.4752% (minimum 75%, Missing); cerebellum: 51.3514% (minimum 75%, Missing); colon: 61.2903% (minimum 70%, Missing); duodenum: 57.5758% (minimum 75%, Missing); esophagus: 59.3750% (minimum 70%, Missing); lung: 73.0769% (minimum 75%, Missing); lymph node: 35.1852% (minimum 70%, Missing); rectum: 55.8824% (minimum 70%, Missing); retina: 44.1860% (minimum 75%, Missing); skin: 44.1860% (minimum 65%, Missing); small intestine: 59.3750% (minimum 75%, Missing); spleen: 59.3750% (minimum 65%, Missing); stomach: 65.5172% (minimum 70%, Missing); thymus: 26.7606% (minimum 65%, Missing)",-0.382394,-0.348148,-0.615248,0,80,unavailable,12.2,3.5,5.2,"bone marrow: 12.2 nTPM (vital, limit 1); thymus: 5.2 nTPM (manageable, limit 5); lymph node: 3.5 nTPM (protected, limit 3); retina: 2.4 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ATAD5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000176219,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR11H6,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000176256,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HMGB4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000176294,True,compatible,,True,True,True,,0.35,0.180952,0.130952,0,80,unavailable,0.5,0.5,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR4N2,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000176299,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR4M1,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000176302,True,compatible,,True,True,True,,0.32619,0.3,0.22619,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FOXR1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000176401,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 58.8235% (minimum 75%, Missing); amygdala: 37.0370% (minimum 75%, Missing); basal ganglia: 29.7619% (minimum 75%, Missing); cerebellum: 23.9234% (minimum 70%, Approved); cerebral cortex: 31.0559% (minimum 75%, Missing); choroid plexus: 49.5050% (minimum 75%, Missing); colon: 58.1395% (minimum 70%, Missing); heart muscle: 63.2911% (minimum 75%, Missing); hippocampal formation: 39.0625% (minimum 75%, Missing); hypothalamus: 27.0270% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); lung: 70.4225% (minimum 75%, Missing); lymph node: 60.9756% (minimum 65%, Approved); midbrain: 47.1698% (minimum 75%, Missing); pituitary gland: 33.3333% (minimum 75%, Missing); retina: 35.2113% (minimum 75%, Missing); small intestine: 67.5676% (minimum 75%, Missing); spinal cord: 51.5464% (minimum 75%, Missing); thyroid gland: 58.1395% (minimum 65%, Missing); urinary bladder: 63.2911% (minimum 70%, Missing)",-0.0686047,-0.118605,-0.47973,0,7,partial,15.9,3.6,3.6,"cerebellum: 15.9 nTPM (vital, limit 2); hypothalamus: 13.5 nTPM (vital, limit 1); basal ganglia: 11.8 nTPM (vital, limit 1); cerebral cortex: 11.1 nTPM (vital, limit 1); pituitary gland: 10 nTPM (vital, limit 1); retina: 9.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); hippocampal formation: 7.8 nTPM (vital, limit 1); midbrain: 5.6 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); spinal cord: 4.7 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); adrenal gland: 3.5 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EID2B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000176563,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342754,0.227765,0.214789,0,80,unavailable,1.5,3.2,0.3,"stomach: 3.2 nTPM (protected, limit 3); kidney: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CNTD1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000176566,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DCAF4L2,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000176571,True,compatible,,True,True,True,,0.292308,0.28,0.23,0,80,unavailable,0.1,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CNBD1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000176597,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.8153% (minimum 65%, Uncertain); bone marrow: 15.0393% (minimum 75%, Missing); colon: 37.9603% (minimum 70%, Missing); duodenum: 26.5347% (minimum 75%, Missing); esophagus: 26.9618% (minimum 70%, Missing); lung: 48.0287% (minimum 75%, Missing); pancreas: 65.0485% (minimum 75%, Missing); pituitary gland: 70.5263% (minimum 75%, Missing); rectum: 41.3580% (minimum 70%, Uncertain); salivary gland: 57.7586% (minimum 70%, Uncertain); skeletal muscle: 65.0485% (minimum 75%, Uncertain); skin: 57.2650% (minimum 65%, Missing); small intestine: 24.7232% (minimum 75%, Missing); smooth muscle: 67.3367% (minimum 75%, Missing); stomach: 54.9180% (minimum 70%, Missing); thymus: 64.4231% (minimum 65%, Missing); urinary bladder: 36.5123% (minimum 70%, Missing)",-0.111847,-0.430382,-0.599607,0,1,partial,75.7,36.3,11.5,"bone marrow: 75.7 nTPM (vital, limit 1); small intestine: 40.8 nTPM (vital, limit 1); duodenum: 37.1 nTPM (vital, limit 1); esophagus: 36.3 nTPM (protected, limit 3); urinary bladder: 23.3 nTPM (protected, limit 3); colon: 21.9 nTPM (protected, limit 3); rectum: 19 nTPM (protected, limit 3); lung: 14.5 nTPM (vital, limit 1); adipose tissue: 11.5 nTPM (manageable, limit 5); stomach: 11 nTPM (protected, limit 3); skin: 10 nTPM (manageable, limit 5); salivary gland: 9.8 nTPM (protected, limit 3); thymus: 7.4 nTPM (manageable, limit 5); pancreas: 7.2 nTPM (vital, limit 1); skeletal muscle: 7.2 nTPM (vital, limit 1); smooth muscle: 6.5 nTPM (vital, limit 1); pituitary gland: 5.6 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); spinal cord: 4.3 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 3); kidney: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 3); heart muscle: 3.4 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,B3GNT5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000176635,True,compatible,,True,True,True,,0.35,0.3,0.241071,0,4,partial,2.8,0.1,0.1,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HORMAD2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,False,gained,selectivity_revised
ENSG00000176679,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TGIF2LY,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000176732,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.326456,0.287469,0.214504,0,80,unavailable,2.9,1,1.9,"retina: 2.9 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PFN4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000176746,False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.35,0.3,0.25,0,3,unreliable,0,0,0,,kidney / proximal tubules (microvilli): Medium (Enhanced),57,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEB6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000176771,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.0435% (minimum 65%, Missing); adrenal gland: 74.3590% (minimum 75%, Missing); amygdala: 44.6154% (minimum 75%, Missing); basal ganglia: 41.4286% (minimum 75%, Missing); cerebral cortex: 53.7037% (minimum 75%, Missing); choroid plexus: 60.4167% (minimum 75%, Missing); duodenum: 58.0000% (minimum 75%, Missing); esophagus: 43.2836% (minimum 70%, Missing); heart muscle: 53.7037% (minimum 75%, Missing); hippocampal formation: 40.8451% (minimum 75%, Missing); hypothalamus: 50.8772% (minimum 75%, Missing); kidney: 42.6471% (minimum 75%, Missing); liver: 42.6471% (minimum 75%, Missing); lung: 20.7143% (minimum 75%, Missing); lymph node: 69.0476% (minimum 70%, Missing); midbrain: 36.7089% (minimum 75%, Missing); pancreas: 74.3590% (minimum 75%, Missing); retina: 38.6667% (minimum 75%, Missing); salivary gland: 59.1837% (minimum 70%, Missing); skin: 59.1837% (minimum 65%, Missing); small intestine: 48.3333% (minimum 75%, Missing); spinal cord: 37.1795% (minimum 75%, Missing); spleen: 63.0435% (minimum 65%, Missing); stomach: 63.0435% (minimum 70%, Missing)",-0.0581633,-0.267164,-0.542857,0,80,unavailable,11.1,3.8,2,"lung: 11.1 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); spinal cord: 4.9 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); basal ganglia: 4.1 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); liver: 3.9 nTPM (vital, limit 1); esophagus: 3.8 nTPM (protected, limit 3); amygdala: 3.6 nTPM (vital, limit 1); small intestine: 3.1 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); heart muscle: 2.5 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NCKAP5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000176774,True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEB18,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000176782,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,1.6,0,,,53,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,DEFB104A,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000176787,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR52E2,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000176895,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR51A7,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000176922,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR51S1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000176927,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.326471,0.182979,0.123684,0,80,unavailable,1.2,1.1,0.2,"bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EFCAB5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000176979,True,compatible,,True,True,True,,0.2875,0.3,0.25,0,2,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRIM60,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000176988,True,compatible,,True,True,True,,0.35,0.3,0.248233,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FMR1NB,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000177023,False,unresolved,unresolved_reproductive_selectivity;existing_nomination_or_manual_review,True,True,True,,,,,0,0,routine_complete,0,0.2,0,,,55,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,DEFB104B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000177025,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 43.4783% (minimum 75%, Missing); retina: 70.5882% (minimum 75%, Missing)",0.225912,0.213309,-0.315217,0,6,partial,15.6,1.9,1.7,"choroid plexus: 15.6 nTPM (vital, limit 1); retina: 5 nTPM (vital, limit 1); heart muscle: 4.7 nTPM (vital, limit 2); pituitary gland: 3.8 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 2); spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 2); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1)",thyroid gland / glandular cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C19orf18,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000177058,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.21646,0.136582,0.0260779,0,7,partial,16.1,10.9,8.6,"liver: 16.1 nTPM (vital, limit 1); pancreas: 11.8 nTPM (vital, limit 1); lymph node: 10.9 nTPM (protected, limit 3); parathyroid gland: 10.3 nTPM (protected, limit 3); retina: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 3); colon: 9.1 nTPM (protected, limit 3); thymus: 8.6 nTPM (manageable, limit 5); smooth muscle: 8.2 nTPM (vital, limit 1); urinary bladder: 8.1 nTPM (protected, limit 3); spleen: 8.1 nTPM (manageable, limit 5); esophagus: 8.1 nTPM (protected, limit 3); stomach: 7.9 nTPM (protected, limit 3); duodenum: 7.8 nTPM (vital, limit 1); lung: 7.7 nTPM (vital, limit 1); skin: 7.4 nTPM (manageable, limit 5); thyroid gland: 7.4 nTPM (manageable, limit 5); kidney: 7.1 nTPM (vital, limit 1); bone marrow: 7 nTPM (vital, limit 1); small intestine: 6.4 nTPM (vital, limit 1); salivary gland: 6.2 nTPM (protected, limit 3); adipose tissue: 6.2 nTPM (manageable, limit 5); cerebral cortex: 4.8 nTPM (vital, limit 1); cerebellum: 4.8 nTPM (vital, limit 1); adrenal gland: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 1); spinal cord: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); heart muscle: 3.7 nTPM (vital, limit 1); basal ganglia: 3.7 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 3); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); liver / hepatocytes: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC38A9,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-020-19141-w,"Bradley et al., Nature Communications (2020);Bruggeman 2018",False,False,False,False,False,unchanged,
ENSG00000177138,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 65.5172% (minimum 75%, Missing)",0.284426,0.266102,-0.0948276,0,80,unavailable,3,0.2,0.4,"liver: 3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM9B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000177143,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CETN1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000177202,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,3,3.5,1.3,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPACA4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,True,True,True,True,False,unchanged,
ENSG00000177272,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 42.8571% (minimum 60%, Approved); amygdala: 50.0000% (minimum 75%, Missing); basal ganglia: 25.0000% (minimum 75%, Missing); cerebellum: 33.3333% (minimum 75%, Missing); cerebral cortex: 37.5000% (minimum 75%, Missing); colon: 33.3333% (minimum 65%, Approved); heart muscle: 60.0000% (minimum 70%, Approved); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 21.4286% (minimum 75%, Missing); kidney: 60.0000% (minimum 70%, Approved); liver: 60.0000% (minimum 70%, Approved); lung: 12.5000% (minimum 70%, Approved); midbrain: 60.0000% (minimum 75%, Missing); pituitary gland: 42.8571% (minimum 75%, Missing); salivary gland: 27.2727% (minimum 65%, Approved); small intestine: 13.6364% (minimum 70%, Approved); spinal cord: 50.0000% (minimum 75%, Missing); spleen: 10.7143% (minimum 60%, Approved); stomach: 42.8571% (minimum 65%, Approved); thyroid gland: 37.5000% (minimum 60%, Approved); urinary bladder: 60.0000% (minimum 65%, Approved)",-0.492857,-0.377273,-0.575,0,0,routine_complete,2.1,0.8,2.5,"lung: 2.1 nTPM (vital, limit 2); hypothalamus: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KCNA3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000177294,True,compatible,,True,True,True,,0.339933,0.289933,0.223597,0,80,unavailable,0.8,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FBXO39,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000177324,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.2,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BEND2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000177398,True,compatible,,True,True,True,,0.119231,0.209091,0.0833333,0,80,unavailable,0.2,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,UMODL1,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,True,True,True,True,gained,selectivity_revised
ENSG00000177414,True,compatible,,True,True,True,,0.35,0.234844,0.226331,0,80,unavailable,0.8,2.3,0,,,0,not_established,required,local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,UBE2U,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,True,True,True,gained,grid_revised
ENSG00000177483,True,compatible,,True,True,True,,0.35,0.280769,0.230769,0,5,partial,0.5,0.3,0.3,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RBM44,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000177504,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,adrenal gland / glandular cells: Low (Enhanced),54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,VCX2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000177558,True,compatible,,True,True,True,,0.35,0.3,0.248505,0,2,partial,0.1,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM187B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000177627,True,compatible,,True,True,True,,0.347429,0.289796,0.242327,0,80,unavailable,0.3,0.4,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C12orf54,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000177673,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX44,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,True,True,True,True,True,unchanged,
ENSG00000177684,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,DEFB114,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000177689,True,compatible,,True,True,True,,0.273077,0.26,0.138889,0,80,unavailable,0.3,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEB10,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000177692,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 72.3404% (minimum 75%, Missing); cerebral cortex: 71.5789% (minimum 75%, Missing); heart muscle: 70.8333% (minimum 75%, Missing); kidney: 73.1183% (minimum 75%, Missing); liver: 73.1183% (minimum 75%, Missing); skeletal muscle: 71.5789% (minimum 75%, Missing)",0.0891304,0.0816092,-0.0416667,0,0,routine_complete,2.8,1.9,2.4,"heart muscle: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAJC28,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000177694,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 67.7778% (minimum 70%, Missing); kidney: 65.5914% (minimum 75%, Missing); liver: 68.5393% (minimum 70%, Approved); pancreas: 74.3902% (minimum 75%, Missing); parathyroid gland: 38.1250% (minimum 70%, Missing); salivary gland: 52.1368% (minimum 70%, Missing); smooth muscle: 64.2105% (minimum 70%, Approved); urinary bladder: 62.2449% (minimum 70%, Missing)",0.0761905,-0.31875,-0.094086,0,8,partial,3.4,9.9,2.3,"parathyroid gland: 9.9 nTPM (protected, limit 3); salivary gland: 5.6 nTPM (protected, limit 3); urinary bladder: 3.7 nTPM (protected, limit 3); smooth muscle: 3.4 nTPM (vital, limit 2); kidney: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 2); heart muscle: 2.5 nTPM (vital, limit 2); pancreas: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NAALADL2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000177839,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.0769% (minimum 75%, Missing); amygdala: 65.5172% (minimum 75%, Missing); basal ganglia: 73.0769% (minimum 75%, Missing); cerebellum: 65.5172% (minimum 75%, Missing); cerebral cortex: 31.1475% (minimum 75%, Missing); colon: 65.5172% (minimum 70%, Missing); heart muscle: 63.3333% (minimum 75%, Missing); hippocampal formation: 67.8571% (minimum 75%, Missing); hypothalamus: 73.0769% (minimum 75%, Missing); lung: 63.3333% (minimum 75%, Missing); pancreas: 73.0769% (minimum 75%, Missing); parathyroid gland: 63.3333% (minimum 70%, Missing); pituitary gland: 44.1860% (minimum 75%, Missing); retina: 61.2903% (minimum 75%, Missing); salivary gland: 65.5172% (minimum 70%, Missing); smooth muscle: 63.3333% (minimum 75%, Missing); spinal cord: 73.0769% (minimum 75%, Missing); tongue: 67.8571% (minimum 70%, Missing)",0.0285714,-0.0666667,-0.438525,0,6,partial,4.2,1.1,0.9,"cerebral cortex: 4.2 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHB9,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000177842,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.8571% (minimum 65%, Missing); adrenal gland: 55.0000% (minimum 75%, Missing); amygdala: 61.1111% (minimum 75%, Missing); basal ganglia: 57.8947% (minimum 75%, Missing); bone marrow: 41.5094% (minimum 75%, Missing); cerebellum: 40.7407% (minimum 75%, Missing); cerebral cortex: 48.8889% (minimum 75%, Missing); choroid plexus: 61.1111% (minimum 75%, Missing); colon: 55.0000% (minimum 70%, Missing); duodenum: 57.8947% (minimum 75%, Missing); esophagus: 68.7500% (minimum 70%, Missing); heart muscle: 57.8947% (minimum 75%, Missing); hippocampal formation: 61.1111% (minimum 75%, Missing); hypothalamus: 59.4595% (minimum 75%, Missing); kidney: 48.8889% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Missing); lung: 51.1628% (minimum 75%, Missing); lymph node: 64.7059% (minimum 70%, Missing); midbrain: 57.8947% (minimum 75%, Missing); pancreas: 47.8261% (minimum 75%, Missing); parathyroid gland: 45.8333% (minimum 70%, Missing); pituitary gland: 47.8261% (minimum 75%, Missing); rectum: 51.1628% (minimum 70%, Missing); retina: 34.9206% (minimum 75%, Missing); salivary gland: 68.7500% (minimum 70%, Missing); skeletal muscle: 46.8085% (minimum 75%, Missing); small intestine: 59.4595% (minimum 75%, Missing); smooth muscle: 59.4595% (minimum 75%, Missing); spinal cord: 59.4595% (minimum 75%, Missing); spleen: 56.4103% (minimum 65%, Missing); stomach: 45.8333% (minimum 70%, Missing); thymus: 59.4595% (minimum 65%, Missing); thyroid gland: 40.0000% (minimum 65%, Missing); tongue: 50.0000% (minimum 70%, Missing); urinary bladder: 62.8571% (minimum 70%, Missing)",-0.25,-0.241667,-0.400794,0,80,unavailable,4.1,2.6,3.3,"retina: 4.1 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF620,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000177873,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6364% (minimum 65%, Missing); adrenal gland: 63.6364% (minimum 75%, Missing); amygdala: 70.0000% (minimum 75%, Missing); basal ganglia: 68.2927% (minimum 75%, Missing); bone marrow: 48.2759% (minimum 75%, Missing); cerebellum: 65.1163% (minimum 75%, Missing); cerebral cortex: 60.8696% (minimum 75%, Missing); choroid plexus: 71.7949% (minimum 75%, Missing); colon: 58.3333% (minimum 70%, Missing); duodenum: 54.9020% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 62.2222% (minimum 75%, Missing); hippocampal formation: 70.0000% (minimum 75%, Missing); hypothalamus: 71.7949% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); liver: 54.9020% (minimum 75%, Missing); lung: 59.5745% (minimum 75%, Missing); lymph node: 54.9020% (minimum 70%, Missing); midbrain: 68.2927% (minimum 75%, Missing); pancreas: 53.8462% (minimum 75%, Missing); parathyroid gland: 48.2759% (minimum 70%, Missing); pituitary gland: 71.7949% (minimum 75%, Missing); rectum: 52.8302% (minimum 70%, Missing); retina: 41.1765% (minimum 75%, Missing); salivary gland: 51.8519% (minimum 70%, Missing); skeletal muscle: 52.8302% (minimum 75%, Missing); skin: 54.9020% (minimum 65%, Missing); small intestine: 59.5745% (minimum 75%, Missing); smooth muscle: 56.0000% (minimum 75%, Missing); spinal cord: 63.6364% (minimum 75%, Missing); spleen: 49.1228% (minimum 65%, Missing); stomach: 54.9020% (minimum 70%, Missing); thyroid gland: 49.1228% (minimum 65%, Missing); tongue: 57.1429% (minimum 70%, Missing); urinary bladder: 63.6364% (minimum 70%, Missing)",-0.158772,-0.217241,-0.338235,0,4,partial,4,3,2.9,"retina: 4 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF619,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000177910,False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA31C2,current_adaptive,True,False,False,False,10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Loriot 2025 · strict;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000177938,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,1.2,1.2,2.1,,,55,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CAPZA3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,False,unchanged,
ENSG00000177947,True,compatible,,True,True,True,,0.35,0.3,0.207895,0,3,partial,0.4,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CIMAP1A,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000177992,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA31E1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000177994,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328131,0.284,0.178302,0,80,unavailable,3.8,0.8,1.1,"choroid plexus: 3.8 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CIMIP6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000178021,True,compatible,,True,True,True,,0.35,0.3,0.245215,0,1,partial,0.1,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TSPYL6,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000178053,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skeletal muscle: 68.5106% (minimum 75%, Missing)",0.344026,0.0877727,-0.0648944,0,7,partial,175.9,103.1,16,"skeletal muscle: 175.9 nTPM (vital, limit 1); heart muscle: 134.3 nTPM (vital, limit 6); tongue: 103.1 nTPM (protected, limit 3); choroid plexus: 93.2 nTPM (vital, limit 1); retina: 45.4 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); kidney: 20.4 nTPM (vital, limit 6); hypothalamus: 20.2 nTPM (vital, limit 1); parathyroid gland: 19.6 nTPM (protected, limit 12); hippocampal formation: 18.9 nTPM (vital, limit 1); amygdala: 18 nTPM (vital, limit 1); pituitary gland: 17.6 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 6); midbrain: 16.6 nTPM (vital, limit 1); cerebral cortex: 15.8 nTPM (vital, limit 6); spinal cord: 15.3 nTPM (vital, limit 1); smooth muscle: 13.6 nTPM (vital, limit 6); urinary bladder: 13.6 nTPM (protected, limit 12); colon: 9.6 nTPM (protected, limit 3); pancreas: 9.3 nTPM (vital, limit 6); cerebellum: 7.4 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 6)",bronchus / respiratory epithelial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MLF1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000178093,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340876,0.294505,0.242687,0,80,unavailable,1.2,0.9,1.5,"liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TSSK6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000178125,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.317391,0.267391,0.14,0,80,unavailable,1.1,0.3,0.3,"choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PPP1R42,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000178177,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 61.2903% (minimum 75%, Missing); amygdala: 71.2500% (minimum 75%, Missing); bone marrow: 61.2903% (minimum 75%, Missing); cerebellum: 62.6374% (minimum 75%, Missing); cerebral cortex: 68.6747% (minimum 75%, Missing); colon: 64.7727% (minimum 70%, Missing); duodenum: 50.4425% (minimum 75%, Missing); hippocampal formation: 70.3704% (minimum 75%, Missing); hypothalamus: 65.5172% (minimum 75%, Missing); kidney: 59.3750% (minimum 75%, Missing); liver: 63.3333% (minimum 75%, Missing); lung: 67.8571% (minimum 75%, Missing); lymph node: 61.9565% (minimum 70%, Uncertain); midbrain: 69.5122% (minimum 75%, Missing); pancreas: 64.0449% (minimum 75%, Missing); parathyroid gland: 56.4356% (minimum 70%, Uncertain); rectum: 61.9565% (minimum 70%, Missing); retina: 47.1074% (minimum 75%, Missing); skeletal muscle: 67.8571% (minimum 75%, Missing); skin: 54.8077% (minimum 65%, Missing); small intestine: 45.6000% (minimum 75%, Missing); smooth muscle: 68.6747% (minimum 75%, Missing); spinal cord: 64.7727% (minimum 75%, Missing); spleen: 63.3333% (minimum 65%, Uncertain); stomach: 56.4356% (minimum 70%, Missing); thymus: 60.0000% (minimum 65%, Missing); thyroid gland: 61.2903% (minimum 65%, Missing); tongue: 67.0588% (minimum 70%, Missing); urinary bladder: 67.8571% (minimum 70%, Missing)",-0.101923,-0.135644,-0.294,0,1,partial,6.8,4.4,4.7,"small intestine: 6.8 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); duodenum: 5.6 nTPM (vital, limit 1); stomach: 4.4 nTPM (protected, limit 3); parathyroid gland: 4.4 nTPM (protected, limit 3); kidney: 3.9 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); rectum: 3.5 nTPM (protected, limit 3); cerebellum: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); pancreas: 3.2 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); hypothalamus: 3 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); smooth muscle: 2.6 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LCORL,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000178229,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.0769% (minimum 75%, Missing); bone marrow: 67.8571% (minimum 75%, Missing); cerebellum: 70.3704% (minimum 75%, Missing); cerebral cortex: 71.6981% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 73.0769% (minimum 75%, Missing); kidney: 71.6981% (minimum 75%, Missing); lung: 70.3704% (minimum 75%, Missing); lymph node: 62.2951% (minimum 70%, Missing); pancreas: 67.8571% (minimum 75%, Missing); parathyroid gland: 56.7164% (minimum 70%, Missing); pituitary gland: 69.0909% (minimum 75%, Missing); retina: 59.3750% (minimum 75%, Missing); skeletal muscle: 69.0909% (minimum 75%, Missing); skin: 62.2951% (minimum 65%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spleen: 60.3175% (minimum 65%, Missing); thymus: 55.0725% (minimum 65%, Missing); thyroid gland: 60.3175% (minimum 65%, Missing); tongue: 67.8571% (minimum 70%, Missing)",-0.0992754,-0.132836,-0.15625,0,80,unavailable,2.6,2.9,3.1,"retina: 2.6 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF543,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000178257,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343103,0.29654,0.220787,0,80,unavailable,2.6,0.3,0.6,"bone marrow: 2.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRM3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000178279,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TNP2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000178287,True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPAG11A,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000178295,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 37.5000% (minimum 75%, Missing); choroid plexus: 68.1818% (minimum 75%, Missing); colon: 64.2857% (minimum 70%, Missing); duodenum: 74.3802% (minimum 75%, Missing); esophagus: 62.5000% (minimum 70%, Missing); liver: 51.7241% (minimum 75%, Missing); lymph node: 46.1538% (minimum 70%, Missing); rectum: 57.3248% (minimum 70%, Missing); skin: 55.2147% (minimum 65%, Missing); small intestine: 67.1642% (minimum 75%, Missing); spleen: 64.2857% (minimum 65%, Missing); thymus: 62.9371% (minimum 65%, Missing)",-0.0978528,-0.238462,-0.375,0,3,partial,15,10.5,7.3,"bone marrow: 15 nTPM (vital, limit 1); lymph node: 10.5 nTPM (protected, limit 3); liver: 8.4 nTPM (vital, limit 1); skin: 7.3 nTPM (manageable, limit 5); rectum: 6.7 nTPM (protected, limit 3); esophagus: 5.4 nTPM (protected, limit 3); thymus: 5.3 nTPM (manageable, limit 5); colon: 5 nTPM (protected, limit 3); small intestine: 4.4 nTPM (vital, limit 1); choroid plexus: 4.2 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells: Low (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: High (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GEN1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000178297,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 47.3684% (minimum 75%, Missing); spleen: 61.0169% (minimum 65%, Missing)",-0.0398305,0.223077,-0.276316,0,80,unavailable,4,0.3,2.3,"liver: 4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TMPRSS9,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000178385,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.7241% (minimum 65%, Missing); adrenal gland: 42.8571% (minimum 75%, Missing); amygdala: 54.5455% (minimum 75%, Missing); basal ganglia: 49.1803% (minimum 75%, Missing); bone marrow: 41.6667% (minimum 75%, Missing); cerebellum: 38.9610% (minimum 75%, Missing); cerebral cortex: 36.5854% (minimum 75%, Missing); colon: 50.0000% (minimum 70%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 51.7241% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 43.4783% (minimum 75%, Missing); kidney: 62.5000% (minimum 75%, Missing); liver: 49.1803% (minimum 75%, Missing); lung: 50.8475% (minimum 75%, Missing); lymph node: 68.1818% (minimum 70%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 57.6923% (minimum 75%, Missing); parathyroid gland: 43.4783% (minimum 70%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); rectum: 68.1818% (minimum 70%, Missing); retina: 27.0270% (minimum 75%, Missing); salivary gland: 58.8235% (minimum 70%, Missing); skeletal muscle: 56.6038% (minimum 75%, Missing); skin: 54.5455% (minimum 65%, Missing); small intestine: 62.5000% (minimum 75%, Missing); smooth muscle: 62.5000% (minimum 75%, Missing); spinal cord: 44.7761% (minimum 75%, Missing); spleen: 62.5000% (minimum 65%, Missing); stomach: 57.6923% (minimum 70%, Missing); thymus: 58.8235% (minimum 65%, Missing); thyroid gland: 46.1538% (minimum 65%, Missing); tongue: 66.6667% (minimum 70%, Missing); urinary bladder: 61.2245% (minimum 70%, Missing)",-0.188462,-0.265217,-0.47973,0,1,partial,8.1,3.9,3.5,"retina: 8.1 nTPM (vital, limit 1); cerebral cortex: 5.2 nTPM (vital, limit 1); cerebellum: 4.7 nTPM (vital, limit 1); bone marrow: 4.2 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 3); spinal cord: 3.7 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); liver: 3.1 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PLEKHM3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000178386,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 63.6364% (minimum 75%, Missing); amygdala: 70.0000% (minimum 75%, Missing); basal ganglia: 63.6364% (minimum 75%, Missing); cerebellum: 55.2632% (minimum 75%, Missing); cerebral cortex: 60.0000% (minimum 75%, Missing); choroid plexus: 74.1176% (minimum 75%, Missing); colon: 59.4340% (minimum 70%, Missing); duodenum: 61.7647% (minimum 75%, Missing); esophagus: 68.4783% (minimum 70%, Missing); heart muscle: 57.2727% (minimum 75%, Missing); hippocampal formation: 67.0213% (minimum 75%, Missing); hypothalamus: 63.6364% (minimum 75%, Missing); kidney: 62.3762% (minimum 75%, Missing); lung: 62.3762% (minimum 70%, Approved); lymph node: 64.2857% (minimum 65%, Approved); midbrain: 70.0000% (minimum 75%, Missing); pancreas: 69.2308% (minimum 75%, Missing); parathyroid gland: 57.2727% (minimum 70%, Missing); pituitary gland: 61.1650% (minimum 75%, Missing); rectum: 53.3898% (minimum 70%, Missing); retina: 59.4340% (minimum 75%, Missing); salivary gland: 64.2857% (minimum 70%, Missing); skin: 56.7568% (minimum 60%, Approved); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 63.0000% (minimum 70%, Approved); spinal cord: 71.5909% (minimum 75%, Missing); spleen: 56.7568% (minimum 60%, Approved); stomach: 57.2727% (minimum 70%, Missing); thyroid gland: 50.4000% (minimum 65%, Missing); urinary bladder: 62.3762% (minimum 70%, Missing)",-0.146,-0.166102,-0.197368,0,8,partial,5.1,5.5,6.2,"thyroid gland: 6.2 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 3); cerebellum: 5.1 nTPM (vital, limit 1); parathyroid gland: 4.7 nTPM (protected, limit 3); stomach: 4.7 nTPM (protected, limit 3); heart muscle: 4.7 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 3); retina: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.2 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); lung: 3.8 nTPM (vital, limit 2); urinary bladder: 3.8 nTPM (protected, limit 3); kidney: 3.8 nTPM (vital, limit 1); smooth muscle: 3.7 nTPM (vital, limit 2); hypothalamus: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 3); hippocampal formation: 3.1 nTPM (vital, limit 1); pancreas: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 2); spinal cord: 2.5 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF223,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000178395,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC185,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000178403,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 51.6129% (minimum 75%, Missing); basal ganglia: 43.2432% (minimum 75%, Missing); cerebellum: 45.7143% (minimum 75%, Missing); hippocampal formation: 44.4444% (minimum 75%, Missing)",0.35,0.3,-0.317568,0,80,unavailable,2.1,0,0,"basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NEUROG2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000178404,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335714,0.275265,0.182432,0,80,unavailable,2,0.7,0.4,"bone marrow: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CEP295NL,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000178409,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing); cerebellum: 58.0645% (minimum 75%, Missing); cerebral cortex: 66.6667% (minimum 75%, Missing); colon: 56.2500% (minimum 70%, Missing); duodenum: 60.0000% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 64.2857% (minimum 75%, Missing); kidney: 62.0690% (minimum 75%, Missing); liver: 72.0000% (minimum 75%, Missing); lung: 69.2308% (minimum 75%, Missing); lymph node: 69.2308% (minimum 70%, Missing); pancreas: 54.5455% (minimum 75%, Missing); pituitary gland: 69.2308% (minimum 75%, Missing); rectum: 54.5455% (minimum 70%, Missing); retina: 69.2308% (minimum 75%, Missing); salivary gland: 56.2500% (minimum 70%, Missing); skeletal muscle: 60.0000% (minimum 75%, Uncertain); small intestine: 64.2857% (minimum 75%, Missing); smooth muscle: 72.0000% (minimum 75%, Missing); stomach: 48.6486% (minimum 70%, Missing); thymus: 64.2857% (minimum 65%, Missing)",-0.00714286,-0.213514,-0.204545,0,1,partial,1.5,1.9,1,"pancreas: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BEND3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000178460,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 73.8854% (minimum 75%, Missing); retina: 72.9560% (minimum 75%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing)",0.196715,0.111189,-0.0833333,0,80,unavailable,5.8,2.7,2.1,"skeletal muscle: 5.8 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MCMDC2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000178502,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 51.3661% (minimum 75%, Missing); cerebral cortex: 59.4937% (minimum 75%, Missing); parathyroid gland: 68.1159% (minimum 70%, Missing); retina: 58.0247% (minimum 75%, Missing); skeletal muscle: 69.6296% (minimum 75%, Missing)",0.0361314,-0.0188406,-0.236339,0,0,routine_complete,8.9,4.4,4.3,"bone marrow: 8.9 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); parathyroid gland: 4.4 nTPM (protected, limit 3); skeletal muscle: 4.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KLHL11,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000178573,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 58.2298% (minimum 65%, Missing); adrenal gland: 71.4286% (minimum 75%, Missing); duodenum: 35.4108% (minimum 75%, Missing); esophagus: 63.0252% (minimum 70%, Missing); kidney: 44.6429% (minimum 75%, Missing); liver: 60.0000% (minimum 75%, Missing); lung: 67.3250% (minimum 75%, Missing); lymph node: 55.3914% (minimum 70%, Missing); parathyroid gland: 43.2526% (minimum 70%, Missing); skeletal muscle: 43.9625% (minimum 75%, Missing); skin: 39.9787% (minimum 65%, Missing); small intestine: 31.7259% (minimum 75%, Missing); smooth muscle: 68.5558% (minimum 75%, Missing); spleen: 59.7134% (minimum 65%, Missing); thyroid gland: 62.6043% (minimum 65%, Missing); tongue: 66.3717% (minimum 70%, Missing); urinary bladder: 68.6813% (minimum 70%, Missing)",-0.250213,-0.267474,-0.432741,0,0,routine_complete,80.7,49.2,56.3,"small intestine: 80.7 nTPM (vital, limit 1); duodenum: 68.4 nTPM (vital, limit 1); skin: 56.3 nTPM (manageable, limit 5); parathyroid gland: 49.2 nTPM (protected, limit 3); skeletal muscle: 47.8 nTPM (vital, limit 1); kidney: 46.5 nTPM (vital, limit 1); lymph node: 30.2 nTPM (protected, limit 3); adipose tissue: 26.9 nTPM (manageable, limit 5); spleen: 25.3 nTPM (manageable, limit 5); liver: 25 nTPM (vital, limit 1); thyroid gland: 22.4 nTPM (manageable, limit 5); esophagus: 22 nTPM (protected, limit 3); tongue: 19 nTPM (protected, limit 3); lung: 18.2 nTPM (vital, limit 1); thymus: 17.4 nTPM (manageable, limit 5); smooth muscle: 17.2 nTPM (vital, limit 1); urinary bladder: 17.1 nTPM (protected, limit 3); adrenal gland: 15 nTPM (vital, limit 1); stomach: 12.7 nTPM (protected, limit 3); spinal cord: 11.8 nTPM (vital, limit 1); salivary gland: 11.5 nTPM (protected, limit 3); colon: 11 nTPM (protected, limit 3); cerebral cortex: 10.7 nTPM (vital, limit 1); rectum: 10.4 nTPM (protected, limit 3); cerebellum: 10.1 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); midbrain: 8.7 nTPM (vital, limit 1); hippocampal formation: 7.6 nTPM (vital, limit 1); basal ganglia: 7.1 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); choroid plexus: 5.1 nTPM (vital, limit 1); pituitary gland: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); bone marrow: 4 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAF,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000178591,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DEFB125,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000178645,True,compatible,,True,True,True,,0.35,0.3,0.242268,0,1,partial,0.3,0,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C10orf53,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000178665,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 69.2308% (minimum 75%, Missing); basal ganglia: 70.5882% (minimum 75%, Missing); bone marrow: 69.2308% (minimum 75%, Missing); cerebral cortex: 61.0169% (minimum 75%, Missing); hippocampal formation: 69.2308% (minimum 75%, Missing); hypothalamus: 70.5882% (minimum 75%, Missing); midbrain: 69.2308% (minimum 75%, Missing); pituitary gland: 67.9245% (minimum 75%, Missing); retina: 61.0169% (minimum 75%, Missing); skeletal muscle: 67.9245% (minimum 75%, Missing); spinal cord: 57.1429% (minimum 75%, Missing)",0.07,0.02,-0.178571,0,80,unavailable,2.7,1.4,1.4,"spinal cord: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF713,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000178694,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.1429% (minimum 65%, Missing); adrenal gland: 54.2373% (minimum 75%, Missing); amygdala: 62.7451% (minimum 75%, Missing); basal ganglia: 53.3333% (minimum 75%, Missing); bone marrow: 47.0588% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing); cerebral cortex: 60.3774% (minimum 75%, Missing); choroid plexus: 72.7273% (minimum 75%, Missing); colon: 48.4848% (minimum 70%, Missing); duodenum: 51.6129% (minimum 75%, Missing); esophagus: 59.2593% (minimum 70%, Missing); heart muscle: 58.1818% (minimum 75%, Missing); hippocampal formation: 60.3774% (minimum 75%, Missing); hypothalamus: 59.2593% (minimum 75%, Missing); kidney: 58.1818% (minimum 75%, Missing); liver: 51.6129% (minimum 75%, Missing); lung: 55.1724% (minimum 75%, Missing); lymph node: 50.7937% (minimum 70%, Missing); midbrain: 60.3774% (minimum 75%, Missing); pancreas: 51.6129% (minimum 75%, Missing); parathyroid gland: 59.2593% (minimum 70%, Missing); pituitary gland: 59.2593% (minimum 75%, Missing); rectum: 45.7143% (minimum 70%, Missing); retina: 49.2308% (minimum 75%, Missing); salivary gland: 55.1724% (minimum 70%, Missing); skeletal muscle: 74.4186% (minimum 75%, Missing); skin: 50.7937% (minimum 65%, Missing); small intestine: 52.4590% (minimum 75%, Missing); smooth muscle: 57.1429% (minimum 75%, Missing); spinal cord: 58.1818% (minimum 75%, Missing); spleen: 48.4848% (minimum 65%, Missing); stomach: 50.7937% (minimum 70%, Missing); thymus: 50.0000% (minimum 65%, Missing); thyroid gland: 52.4590% (minimum 65%, Missing); urinary bladder: 56.1404% (minimum 70%, Missing)",-0.165152,-0.242857,-0.279412,0,80,unavailable,3.6,3.8,3.4,"rectum: 3.8 nTPM (protected, limit 3); bone marrow: 3.6 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); retina: 3.3 nTPM (vital, limit 1); stomach: 3.1 nTPM (protected, limit 3); lymph node: 3.1 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NSUN3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000178795,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 72.0000% (minimum 75%, Missing)",0.322973,0.3,-0.03,0,80,unavailable,1.4,0,0.1,"retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GDPD4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000178796,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 70.6745% (minimum 75%, Missing); pituitary gland: 41.6235% (minimum 75%, Missing)",0.35,0.260159,-0.333765,0,10,partial,33.8,1,0,"pituitary gland: 33.8 nTPM (vital, limit 1); basal ganglia: 10 nTPM (vital, limit 1); hypothalamus: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); amygdala: 5.4 nTPM (vital, limit 1); retina: 4.7 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / enterocytes - Microvilli: Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced); rectum / enterocytes - Microvilli: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),82,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RIIAD1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000178804,False,excluded,positive_ihc_outside_permitted;family_exclusion,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,cerebellum / cells in molecular layer: Low (Enhanced),52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,H1-8,current_adaptive,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000178852,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"thyroid gland: 59.2814% (minimum 65%, Missing)",-0.0571856,0.121577,0.042,0,80,unavailable,5.2,4.3,13.6,"thyroid gland: 13.6 nTPM (manageable, limit 5); kidney: 5.2 nTPM (vital, limit 1); duodenum: 4.6 nTPM (vital, limit 1); lymph node: 4.3 nTPM (protected, limit 3); bone marrow: 3.8 nTPM (vital, limit 1); retina: 3.8 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); liver: 3.3 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); rectum: 3.2 nTPM (protected, limit 3); lung: 3 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EFCAB13,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000178928,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,1.1,0,0,"retina: 1.1 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TPRX1,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000178997,True,compatible,,True,True,True,,0.336395,0.3,0.223154,0,80,unavailable,0.4,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EXD1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,True,True,True,True,gained,selectivity_revised
ENSG00000179008,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 69.0789% (minimum 75%, Missing)",0.322222,0,-0.0592105,0,80,unavailable,4.7,4.5,0.3,"pituitary gland: 4.7 nTPM (vital, limit 1); salivary gland: 4.5 nTPM (protected, limit 3); tongue: 3.5 nTPM (protected, limit 3); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,appendix; salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C14orf39,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000179046,True,compatible,,True,True,True,,0.35,0.275,0.156977,0,80,unavailable,0.4,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRIML2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000179055,False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR13D1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000179059,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 74.0741% (minimum 75%, Missing)",0.15,0.133333,-0.00925926,0,80,unavailable,0.7,0.4,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZFP42,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000179071,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.340654,0.283759,0.213636,0,5,partial,1.6,1.2,0.6,"retina: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / basal cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC89,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000179083,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 73.5294% (minimum 75%, Missing); basal ganglia: 61.4754% (minimum 75%, Missing); cerebral cortex: 70.7547% (minimum 75%, Missing); hypothalamus: 61.9835% (minimum 75%, Missing)",0.324026,0.286842,-0.135246,0,80,unavailable,4.7,0.1,0.2,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM133A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000179088,True,compatible,,True,True,True,,0.277778,0.254286,0.226608,0,80,unavailable,0.4,0.8,1.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C12orf42,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000179133,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 68.5714% (minimum 75%, Missing)",0.309091,0.291736,-0.0642857,0,6,partial,5.5,0.4,1.2,"choroid plexus: 5.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 2); pituitary gland: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Low (Approved); nasopharynx / ciliated cells (tip of cilia): Low (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C10orf67,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000179142,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,0,routine_complete,173.3,0.1,0,"adrenal gland: 173.3 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: High (Supported); adrenal gland / cells in zona glomerulosa: High (Supported); adrenal gland / cells in zona reticularis: High (Supported); adrenal gland / glandular cells: High (Supported),59,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,CYP11B2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000179165,True,compatible,,True,True,True,,0.306522,0.256522,0.13,0,80,unavailable,0.3,0.1,0.1,,,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PXT1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000179168,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.338384,0.292577,0.220954,0,80,unavailable,2.8,0.7,1.1,"small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GGN,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000179172,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HNRNPCL1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,gained,admission_only
ENSG00000179213,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0.1,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SIGLECL1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000179295,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 41.9689% (minimum 65%, Missing); adrenal gland: 56.4854% (minimum 75%, Missing); amygdala: 35.4641% (minimum 75%, Missing); basal ganglia: 35.9043% (minimum 75%, Missing); bone marrow: 49.4505% (minimum 75%, Missing); cerebellum: 57.2034% (minimum 75%, Missing); cerebral cortex: 37.6045% (minimum 75%, Missing); choroid plexus: 63.7795% (minimum 75%, Missing); colon: 56.3282% (minimum 70%, Missing); duodenum: 60.9023% (minimum 75%, Missing); esophagus: 52.1236% (minimum 70%, Missing); heart muscle: 38.5347% (minimum 75%, Missing); hippocampal formation: 36.2254% (minimum 75%, Missing); hypothalamus: 38.9423% (minimum 75%, Missing); kidney: 52.8721% (minimum 75%, Missing); liver: 46.9293% (minimum 75%, Missing); lung: 56.0942% (minimum 75%, Missing); lymph node: 56.0166% (minimum 70%, Missing); midbrain: 29.9335% (minimum 75%, Missing); pancreas: 58.1062% (minimum 75%, Missing); parathyroid gland: 44.2623% (minimum 70%, Missing); pituitary gland: 72.0641% (minimum 75%, Missing); rectum: 58.1897% (minimum 70%, Missing); retina: 46.9838% (minimum 75%, Missing); salivary gland: 64.6965% (minimum 70%, Missing); skeletal muscle: 35.8407% (minimum 70%, Approved); skin: 61.5502% (minimum 65%, Missing); small intestine: 62.4037% (minimum 75%, Missing); smooth muscle: 48.5612% (minimum 75%, Missing); spinal cord: 29.9778% (minimum 75%, Missing); spleen: 62.2120% (minimum 65%, Missing); stomach: 59.0379% (minimum 70%, Missing); thymus: 54.8038% (minimum 65%, Missing); thyroid gland: 47.4239% (minimum 65%, Missing); tongue: 40.0990% (minimum 70%, Missing); urinary bladder: 51.4612% (minimum 70%, Missing)",-0.230311,-0.29901,-0.450665,0,12,partial,94.8,60.5,56,"midbrain: 94.8 nTPM (vital, limit 1); spinal cord: 94.6 nTPM (vital, limit 1); amygdala: 73.7 nTPM (vital, limit 1); skeletal muscle: 72.5 nTPM (vital, limit 2); basal ganglia: 72.3 nTPM (vital, limit 1); hippocampal formation: 71.3 nTPM (vital, limit 1); cerebral cortex: 67.2 nTPM (vital, limit 1); heart muscle: 64.6 nTPM (vital, limit 1); hypothalamus: 63.5 nTPM (vital, limit 1); tongue: 60.5 nTPM (protected, limit 3); adipose tissue: 56 nTPM (manageable, limit 5); parathyroid gland: 51 nTPM (protected, limit 3); liver: 45.8 nTPM (vital, limit 1); retina: 45.7 nTPM (vital, limit 1); thyroid gland: 44.9 nTPM (manageable, limit 5); smooth muscle: 42.9 nTPM (vital, limit 1); bone marrow: 41.4 nTPM (vital, limit 1); urinary bladder: 38.2 nTPM (protected, limit 3); esophagus: 37.2 nTPM (protected, limit 3); kidney: 36.1 nTPM (vital, limit 1); thymus: 33.4 nTPM (manageable, limit 5); lymph node: 31.8 nTPM (protected, limit 3); lung: 31.7 nTPM (vital, limit 1); colon: 31.4 nTPM (protected, limit 3); adrenal gland: 31.2 nTPM (vital, limit 1); cerebellum: 30.3 nTPM (vital, limit 1); pancreas: 29.2 nTPM (vital, limit 1); rectum: 29.1 nTPM (protected, limit 3); stomach: 28.1 nTPM (protected, limit 3); duodenum: 26 nTPM (vital, limit 1); skin: 25.3 nTPM (manageable, limit 5); spleen: 24.6 nTPM (manageable, limit 5); small intestine: 24.4 nTPM (vital, limit 1); choroid plexus: 23 nTPM (vital, limit 1); salivary gland: 22.1 nTPM (protected, limit 3); pituitary gland: 15.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),44,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PTPN11,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000179299,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 62.2568% (minimum 75%, Missing); pancreas: 69.5652% (minimum 75%, Missing)",0.126699,0.0729469,-0.127432,0,7,partial,9.7,4.7,4.6,"choroid plexus: 9.7 nTPM (vital, limit 1); pancreas: 7 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 3); kidney: 4.5 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); stomach: 3.1 nTPM (protected, limit 3); heart muscle: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NSUN7,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000179363,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346276,0.287996,0.229853,0,80,unavailable,2.2,1.3,0.4,"hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TMEM31,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000179397,True,compatible,,True,True,True,,0.308716,0.263134,0.204338,0,80,unavailable,1,0.8,0.9,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CATSPERE,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000179407,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAJB8,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000179412,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,HNRNPCL4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000179468,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR9A2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000179580,True,compatible,,True,True,True,,0.34946,0.29946,0.24946,0,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RNF151,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000179598,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 69.1275% (minimum 75%, Missing); cerebellum: 48.8152% (minimum 75%, Missing); cerebral cortex: 73.0496% (minimum 75%, Missing); hypothalamus: 68.4385% (minimum 75%, Missing); pituitary gland: 72.2807% (minimum 75%, Missing)",0.177309,0.00307167,-0.261848,0,11,partial,21.6,8.7,4.4,"cerebellum: 21.6 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); colon: 8.7 nTPM (protected, limit 3); pituitary gland: 7.9 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); hippocampal formation: 6.2 nTPM (vital, limit 1); midbrain: 6 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); amygdala: 5.9 nTPM (vital, limit 1); liver: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.5 nTPM (protected, limit 3); spinal cord: 5.3 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); stomach: 4.3 nTPM (protected, limit 3); urinary bladder: 4.1 nTPM (protected, limit 3); adrenal gland: 4 nTPM (vital, limit 2); retina: 3.4 nTPM (vital, limit 1); salivary gland: 3.1 nTPM (protected, limit 3); small intestine: 3.1 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PLD6,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000179600,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,GPHB5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000179603,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.2222% (minimum 75%, Missing); amygdala: 72.2222% (minimum 75%, Missing); basal ganglia: 54.1667% (minimum 75%, Missing); cerebral cortex: 38.2353% (minimum 75%, Missing); choroid plexus: 5.8296% (minimum 75%, Missing); colon: 46.4286% (minimum 70%, Missing); hippocampal formation: 68.4211% (minimum 75%, Missing); hypothalamus: 59.0909% (minimum 75%, Missing); kidney: 68.4211% (minimum 75%, Missing); liver: 32.5000% (minimum 75%, Missing); midbrain: 68.4211% (minimum 75%, Missing); rectum: 40.6250% (minimum 70%, Missing); retina: 40.6250% (minimum 75%, Missing)",0,-0.29375,-0.691704,0,80,unavailable,21,1.9,0.7,"choroid plexus: 21 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; gallbladder; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GRM8,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000179636,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.282157,0.242786,0,3,partial,12.8,4.5,0.1,"liver: 12.8 nTPM (vital, limit 6); tongue: 4.5 nTPM (protected, limit 3); choroid plexus: 1.8 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TPPP2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000179695,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR6C2,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000179709,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"salivary gland: 66.6667% (minimum 70%, Missing)",0.35,-0.0333333,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NLRP8,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000179751,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 0.0997% (minimum 75%, Missing)",0.35,0.3,-0.749003,0,4,partial,27446.4,3.9,4.4,"pancreas: 27446.4 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SYCN,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000179796,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 22.2222% (minimum 75%, Missing); basal ganglia: 22.5806% (minimum 75%, Missing); cerebellum: 24.5614% (minimum 70%, Approved); cerebral cortex: 22.5806% (minimum 75%, Missing); hippocampal formation: 31.1111% (minimum 75%, Missing); hypothalamus: 37.8378% (minimum 75%, Missing); midbrain: 34.8259% (minimum 75%, Missing); skeletal muscle: 43.4783% (minimum 75%, Missing); spinal cord: 60.3448% (minimum 75%, Missing); urinary bladder: 60.3448% (minimum 65%, Approved)",0.259091,-0.0465517,-0.527778,0,1,partial,24.5,4.6,0.7,"amygdala: 24.5 nTPM (vital, limit 1); basal ganglia: 24 nTPM (vital, limit 1); cerebral cortex: 24 nTPM (vital, limit 1); cerebellum: 21.5 nTPM (vital, limit 2); hippocampal formation: 15.5 nTPM (vital, limit 1); midbrain: 13.1 nTPM (vital, limit 1); hypothalamus: 11.5 nTPM (vital, limit 1); skeletal muscle: 9.1 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); urinary bladder: 4.6 nTPM (protected, limit 4); pituitary gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); skeletal muscle / myocytes: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRRC3B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000179817,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MRGPRX4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000179869,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 3.2895% (minimum 75%, Missing); esophagus: 55.5556% (minimum 70%, Missing); kidney: 62.5000% (minimum 75%, Missing); lung: 55.5556% (minimum 75%, Missing); pancreas: 68.1818% (minimum 75%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); salivary gland: 65.2174% (minimum 70%, Missing); skin: 62.5000% (minimum 65%, Missing); thyroid gland: 34.0909% (minimum 65%, Missing)",-0.309091,-0.144444,-0.717105,0,80,unavailable,44.1,1.2,2.9,"bone marrow: 44.1 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ABCA13,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000179873,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"liver: 52.3810% (minimum 75%, Missing)",0.266667,0.146154,-0.22619,0,80,unavailable,1,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NLRP11,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000179919,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR10A7,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000179988,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 60.7143% (minimum 75%, Missing); amygdala: 58.6207% (minimum 75%, Missing); basal ganglia: 58.6207% (minimum 75%, Missing); bone marrow: 35.7895% (minimum 75%, Missing); cerebellum: 72.3404% (minimum 75%, Missing); cerebral cortex: 53.1250% (minimum 75%, Missing); choroid plexus: 72.3404% (minimum 75%, Missing); colon: 69.3878% (minimum 70%, Missing); duodenum: 65.3846% (minimum 75%, Missing); esophagus: 69.3878% (minimum 70%, Missing); heart muscle: 68.0000% (minimum 75%, Missing); hippocampal formation: 55.7377% (minimum 75%, Missing); hypothalamus: 54.8387% (minimum 75%, Missing); kidney: 64.1509% (minimum 75%, Missing); liver: 45.9459% (minimum 75%, Missing); midbrain: 58.6207% (minimum 75%, Missing); pancreas: 62.9630% (minimum 75%, Missing); pituitary gland: 56.6667% (minimum 75%, Missing); salivary gland: 64.1509% (minimum 70%, Missing); skeletal muscle: 50.7463% (minimum 75%, Missing); smooth muscle: 65.3846% (minimum 75%, Missing); spinal cord: 51.5152% (minimum 75%, Missing); thyroid gland: 59.6491% (minimum 65%, Missing)",-0.0535088,-0.0584906,-0.392105,0,4,partial,6.1,1.9,2.3,"bone marrow: 6.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PSTK,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000180016,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skeletal muscle: 66.6667% (minimum 75%, Missing); tongue: 66.6667% (minimum 70%, Missing)",0.35,-0.0333333,-0.0833333,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR1E1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000180043,True,compatible,,True,True,True,,0.35,0.3,0.246403,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GARIN5B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000180083,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333906,0.293499,0.219345,0,80,unavailable,2.9,0.6,1.5,"bone marrow: 2.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,WFDC11,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000180090,True,compatible,,True,True,True,,0.225,0.3,0.125,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR3A1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000180113,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.342857,0.296622,0.0242782,0,2,partial,10.6,3.9,5.5,"cerebellum: 10.6 nTPM (vital, limit 6); retina: 8.6 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TDRD6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000180116,True,compatible,,True,True,True,,0.338506,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,REDIC1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000180138,True,compatible,,True,True,True,,0.321429,0.3,0.121795,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CSNK1A1L,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,True,True,True,True,gained,selectivity_revised
ENSG00000180185,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 49.3776% (minimum 50%, Enhanced); adrenal gland: 38.3871% (minimum 75%, Missing); amygdala: 50.8547% (minimum 75%, Missing); basal ganglia: 56.1321% (minimum 75%, Missing); bone marrow: 53.6036% (minimum 75%, Missing); cerebellum: 58.6207% (minimum 75%, Missing); cerebral cortex: 44.5693% (minimum 75%, Missing); choroid plexus: 53.3632% (minimum 75%, Missing); colon: 34.5930% (minimum 70%, Missing); duodenum: 23.1969% (minimum 75%, Missing); esophagus: 39.9329% (minimum 70%, Missing); heart muscle: 37.7778% (minimum 75%, Missing); hippocampal formation: 49.7908% (minimum 75%, Missing); hypothalamus: 47.9839% (minimum 75%, Missing); kidney: 14.3201% (minimum 75%, Missing); liver: 16.0377% (minimum 75%, Missing); lung: 60.7143% (minimum 75%, Missing); midbrain: 51.2931% (minimum 75%, Missing); pancreas: 43.1159% (minimum 75%, Missing); parathyroid gland: 46.8504% (minimum 70%, Missing); pituitary gland: 56.9378% (minimum 75%, Missing); rectum: 42.3488% (minimum 70%, Missing); retina: 61.9792% (minimum 75%, Missing); salivary gland: 54.0909% (minimum 70%, Missing); skeletal muscle: 28.9538% (minimum 60%, Enhanced); skin: 42.1986% (minimum 65%, Missing); small intestine: 28.5372% (minimum 75%, Missing); smooth muscle: 55.0926% (minimum 60%, Enhanced); spinal cord: 52.6549% (minimum 75%, Missing); spleen: 58.6207% (minimum 65%, Missing); stomach: 38.1410% (minimum 70%, Missing); thymus: 57.4879% (minimum 65%, Missing); thyroid gland: 57.7670% (minimum 65%, Missing); tongue: 30.7494% (minimum 70%, Missing); urinary bladder: 53.1250% (minimum 70%, Missing)",-0.228014,-0.392506,-0.606799,0,17,partial,71.2,26.8,16.3,"kidney: 71.2 nTPM (vital, limit 1); liver: 62.3 nTPM (vital, limit 1); duodenum: 39.4 nTPM (vital, limit 1); small intestine: 29.8 nTPM (vital, limit 1); skeletal muscle: 29.2 nTPM (vital, limit 6); tongue: 26.8 nTPM (protected, limit 3); colon: 22.5 nTPM (protected, limit 3); heart muscle: 19.6 nTPM (vital, limit 1); stomach: 19.3 nTPM (protected, limit 3); adrenal gland: 19.1 nTPM (vital, limit 1); esophagus: 17.9 nTPM (protected, limit 3); skin: 16.3 nTPM (manageable, limit 5); rectum: 16.2 nTPM (protected, limit 3); pancreas: 15.7 nTPM (vital, limit 1); cerebral cortex: 14.8 nTPM (vital, limit 1); parathyroid gland: 13.5 nTPM (protected, limit 3); hypothalamus: 12.9 nTPM (vital, limit 1); hippocampal formation: 12 nTPM (vital, limit 1); amygdala: 11.5 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 10.7 nTPM (vital, limit 1); urinary bladder: 10.5 nTPM (protected, limit 3); choroid plexus: 10.4 nTPM (vital, limit 1); bone marrow: 10.3 nTPM (vital, limit 1); salivary gland: 10.1 nTPM (protected, limit 3); smooth muscle: 9.7 nTPM (vital, limit 6); basal ganglia: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); thymus: 8.8 nTPM (manageable, limit 5); thyroid gland: 8.7 nTPM (manageable, limit 5); spleen: 8.4 nTPM (manageable, limit 5); cerebellum: 8.4 nTPM (vital, limit 1); lung: 7.7 nTPM (vital, limit 1); retina: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in molecular layer: High (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: High (Enhanced); colon / mucosal lymphoid cells: Low (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: High (Enhanced); duodenum / glands of Brunner: Low (Enhanced); duodenum / goblet cells: High (Enhanced); duodenum / paneth cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Medium (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / endothelial cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / endothelial cells: High (Enhanced); rectum / enterocytes: High (Enhanced); rectum / goblet cells: High (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / endothelial cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: High (Enhanced); small intestine / goblet cells: High (Enhanced); small intestine / paneth cells: High (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),111,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / endothelial cells; skin 2 / hair follicles; skin 2 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAHD1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000180205,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,WFDC9,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000180219,True,compatible,,True,True,True,,0.35,0.3,0.246951,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GARIN6,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000180269,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 20.0000% (minimum 75%, Missing); bone marrow: 20.0000% (minimum 75%, Missing); choroid plexus: 50.0000% (minimum 75%, Missing); hypothalamus: 33.3333% (minimum 75%, Missing)",0.35,0.3,-0.55,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GPR139,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000180305,True,compatible,,True,True,True,,0.35,0.299644,0.249644,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,WFDC10A,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000180336,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.218553,0,1,partial,3.3,0.4,0.8,"retina: 1.5 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MEIOC,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000180423,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 68.4211% (minimum 70%, Approved)",0.0905063,0.05,-0.0157895,0,4,partial,5.4,3.9,4.1,"bone marrow: 5.4 nTPM (vital, limit 2); stomach: 3.9 nTPM (protected, limit 3); lymph node: 3.3 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 2); smooth muscle: 2.9 nTPM (vital, limit 2); cerebral cortex: 2.8 nTPM (vital, limit 2); spinal cord: 2.8 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 2); small intestine: 2.7 nTPM (vital, limit 2); retina: 2.6 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 2); skeletal muscle: 2.5 nTPM (vital, limit 2); adrenal gland: 2.5 nTPM (vital, limit 2); midbrain: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 2); pancreas: 2.3 nTPM (vital, limit 2); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 2); hippocampal formation: 2.1 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HARBI1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000180424,True,compatible,,True,True,True,,0.349355,0.3,0.247426,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DEFB123,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000180425,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.267799,0.202472,0.112157,0,80,unavailable,21.6,14.6,12.1,"liver: 21.6 nTPM (vital, limit 1); retina: 15.4 nTPM (vital, limit 1); tongue: 14.6 nTPM (protected, limit 3); skeletal muscle: 14.5 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); kidney: 13.4 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 12.8 nTPM (vital, limit 1); hippocampal formation: 12.3 nTPM (vital, limit 1); thyroid gland: 12.1 nTPM (manageable, limit 5); amygdala: 11.7 nTPM (vital, limit 1); midbrain: 11.3 nTPM (vital, limit 1); spinal cord: 11.2 nTPM (vital, limit 1); adrenal gland: 10.3 nTPM (vital, limit 1); cerebral cortex: 9.9 nTPM (vital, limit 1); salivary gland: 9.5 nTPM (protected, limit 3); spleen: 9.1 nTPM (manageable, limit 5); skin: 9.1 nTPM (manageable, limit 5); heart muscle: 9 nTPM (vital, limit 1); thymus: 8.7 nTPM (manageable, limit 5); parathyroid gland: 8.6 nTPM (protected, limit 3); pancreas: 8.5 nTPM (vital, limit 1); cerebellum: 7.7 nTPM (vital, limit 1); duodenum: 7.4 nTPM (vital, limit 1); small intestine: 7.3 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 3); choroid plexus: 7.1 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 3); lymph node: 6.5 nTPM (protected, limit 3); rectum: 6 nTPM (protected, limit 3); lung: 5.8 nTPM (vital, limit 1); adipose tissue: 5.6 nTPM (manageable, limit 5); urinary bladder: 4.4 nTPM (protected, limit 3); esophagus: 4.2 nTPM (protected, limit 3); bone marrow: 3.7 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C11orf71,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000180479,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.8879% (minimum 75%, Missing); bone marrow: 62.6667% (minimum 75%, Missing); cerebellum: 73.0570% (minimum 75%, Missing); cerebral cortex: 71.9388% (minimum 75%, Missing); choroid plexus: 71.2121% (minimum 75%, Missing); hippocampal formation: 74.2105% (minimum 75%, Missing); hypothalamus: 74.6032% (minimum 75%, Missing); kidney: 66.5094% (minimum 75%, Missing); parathyroid gland: 54.8638% (minimum 70%, Missing); pituitary gland: 62.1145% (minimum 75%, Missing); retina: 33.4917% (minimum 75%, Missing); skin: 62.9464% (minimum 65%, Missing); spinal cord: 72.3077% (minimum 75%, Missing); thyroid gland: 15.7895% (minimum 65%, Missing)",-0.492105,-0.151362,-0.415083,0,80,unavailable,28,11.6,75.2,"thyroid gland: 75.2 nTPM (manageable, limit 5); retina: 28 nTPM (vital, limit 1); parathyroid gland: 11.6 nTPM (protected, limit 3); pituitary gland: 8.6 nTPM (vital, limit 1); bone marrow: 8.4 nTPM (vital, limit 1); skin: 8.3 nTPM (manageable, limit 5); adrenal gland: 7.3 nTPM (vital, limit 1); kidney: 7.1 nTPM (vital, limit 1); thymus: 6 nTPM (manageable, limit 5); choroid plexus: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 3); spinal cord: 5.4 nTPM (vital, limit 1); spleen: 5.3 nTPM (manageable, limit 5); cerebellum: 5.2 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.8 nTPM (vital, limit 1); smooth muscle: 4.6 nTPM (vital, limit 1); midbrain: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 3); skeletal muscle: 4 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); esophagus: 4 nTPM (protected, limit 3); lung: 3.8 nTPM (vital, limit 1); stomach: 3.8 nTPM (protected, limit 3); basal ganglia: 3.8 nTPM (vital, limit 1); tongue: 3.7 nTPM (protected, limit 3); liver: 3.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); salivary gland: 3.2 nTPM (protected, limit 3); pancreas: 3.1 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF571,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000180481,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.322103,0.267949,0.126209,0,3,partial,6.4,3.9,2.3,"spinal cord: 6.4 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GLIPR1L2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000180483,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.175402,0,3,partial,150.8,0.1,0.1,"retina: 150.8 nTPM (vital, limit 1)",,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DEFB119,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000180592,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 72.7273% (minimum 75%, Missing); basal ganglia: 64.0000% (minimum 75%, Missing); bone marrow: 72.7273% (minimum 75%, Missing); cerebellum: 64.0000% (minimum 75%, Missing); cerebral cortex: 61.5385% (minimum 75%, Missing); heart muscle: 57.1429% (minimum 75%, Missing); hippocampal formation: 72.7273% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); liver: 53.3333% (minimum 75%, Missing); parathyroid gland: 61.5385% (minimum 70%, Missing); retina: 51.6129% (minimum 75%, Missing); skin: 61.5385% (minimum 65%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing)",-0.0785714,-0.0846154,-0.233871,0,80,unavailable,1.5,1,1.2,"retina: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SKIDA1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000180628,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.6842% (minimum 60%, Approved); adrenal gland: 42.0330% (minimum 70%, Approved); amygdala: 50.3289% (minimum 75%, Missing); basal ganglia: 53.6842% (minimum 75%, Missing); cerebellum: 61.2000% (minimum 75%, Missing); cerebral cortex: 45.9459% (minimum 75%, Missing); colon: 50.8306% (minimum 65%, Approved); duodenum: 47.2222% (minimum 75%, Missing); esophagus: 55.2347% (minimum 70%, Missing); heart muscle: 35.9155% (minimum 70%, Approved); hippocampal formation: 54.8387% (minimum 75%, Missing); hypothalamus: 50.6623% (minimum 75%, Missing); kidney: 40.3694% (minimum 75%, Missing); liver: 37.5921% (minimum 75%, Missing); lung: 54.6429% (minimum 70%, Approved); lymph node: 48.2650% (minimum 65%, Approved); midbrain: 49.1961% (minimum 75%, Missing); pancreas: 49.5146% (minimum 75%, Missing); parathyroid gland: 44.3478% (minimum 65%, Approved); pituitary gland: 68.6099% (minimum 75%, Missing); rectum: 52.7586% (minimum 65%, Approved); retina: 49.3548% (minimum 75%, Missing); salivary gland: 47.2222% (minimum 65%, Approved); skeletal muscle: 51.1706% (minimum 75%, Missing); skin: 58.3969% (minimum 65%, Missing); small intestine: 42.8571% (minimum 75%, Missing); smooth muscle: 57.0896% (minimum 70%, Approved); spinal cord: 47.8125% (minimum 75%, Missing); spleen: 46.7890% (minimum 60%, Approved); stomach: 51.6892% (minimum 70%, Missing); thymus: 44.7368% (minimum 65%, Missing); thyroid gland: 39.5349% (minimum 60%, Approved); tongue: 48.8818% (minimum 70%, Missing); urinary bladder: 56.4576% (minimum 70%, Missing)",-0.204651,-0.211182,-0.374079,0,7,partial,27.3,19.2,23.4,"heart muscle: 27.3 nTPM (vital, limit 2); liver: 25.4 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (manageable, limit 10); kidney: 22.6 nTPM (vital, limit 1); adrenal gland: 21.1 nTPM (vital, limit 2); small intestine: 20.4 nTPM (vital, limit 1); parathyroid gland: 19.2 nTPM (protected, limit 4); thymus: 18.9 nTPM (manageable, limit 5); cerebral cortex: 18 nTPM (vital, limit 1); spleen: 17.4 nTPM (manageable, limit 10); duodenum: 17.1 nTPM (vital, limit 1); salivary gland: 17.1 nTPM (protected, limit 4); spinal cord: 16.7 nTPM (vital, limit 1); lymph node: 16.4 nTPM (protected, limit 4); tongue: 16 nTPM (protected, limit 3); midbrain: 15.8 nTPM (vital, limit 1); retina: 15.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); amygdala: 15.1 nTPM (vital, limit 1); hypothalamus: 14.9 nTPM (vital, limit 1); colon: 14.8 nTPM (protected, limit 4); skeletal muscle: 14.6 nTPM (vital, limit 1); stomach: 14.3 nTPM (protected, limit 3); rectum: 13.7 nTPM (protected, limit 4); adipose tissue: 13.2 nTPM (manageable, limit 10); basal ganglia: 13.2 nTPM (vital, limit 1); lung: 12.7 nTPM (vital, limit 2); hippocampal formation: 12.6 nTPM (vital, limit 1); esophagus: 12.4 nTPM (protected, limit 3); urinary bladder: 11.8 nTPM (protected, limit 3); smooth muscle: 11.5 nTPM (vital, limit 2); skin: 10.9 nTPM (manageable, limit 5); cerebellum: 9.7 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); bone marrow: 5.7 nTPM (vital, limit 2); choroid plexus: 4.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCGF5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000180658,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 75.0000% (minimum 75%, Missing); duodenum: 75.0000% (minimum 75%, Missing)",0.35,0.05,-1.11022e-16,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR2A4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000180697,True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C3orf22,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000180776,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 49.2958% (minimum 75%, Missing); cerebral cortex: 66.0377% (minimum 75%, Missing); colon: 63.3484% (minimum 70%, Missing); duodenum: 60.4752% (minimum 75%, Missing); esophagus: 49.2091% (minimum 70%, Missing); lung: 63.4921% (minimum 75%, Missing); lymph node: 61.8102% (minimum 70%, Missing); midbrain: 65.7277% (minimum 75%, Missing); rectum: 64.8148% (minimum 70%, Missing); skin: 56.9106% (minimum 65%, Missing); small intestine: 60.6061% (minimum 75%, Missing); smooth muscle: 66.1939% (minimum 75%, Missing); spinal cord: 46.2046% (minimum 75%, Missing); spleen: 64.6651% (minimum 65%, Missing); stomach: 42.4242% (minimum 70%, Missing); thymus: 56.5657% (minimum 65%, Missing); thyroid gland: 64.0732% (minimum 65%, Missing); urinary bladder: 56.2249% (minimum 70%, Missing)",-0.0843434,-0.275758,-0.287954,0,3,partial,32.6,38,21.5,"stomach: 38 nTPM (protected, limit 3); spinal cord: 32.6 nTPM (vital, limit 1); esophagus: 28.9 nTPM (protected, limit 3); bone marrow: 28.8 nTPM (vital, limit 1); urinary bladder: 21.8 nTPM (protected, limit 3); thymus: 21.5 nTPM (manageable, limit 5); skin: 21.2 nTPM (manageable, limit 5); duodenum: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); lymph node: 17.3 nTPM (protected, limit 3); colon: 16.2 nTPM (protected, limit 3); lung: 16.1 nTPM (vital, limit 1); thyroid gland: 15.7 nTPM (manageable, limit 5); spleen: 15.3 nTPM (manageable, limit 5); rectum: 15.2 nTPM (protected, limit 3); midbrain: 14.6 nTPM (vital, limit 1); cerebral cortex: 14.4 nTPM (vital, limit 1); smooth muscle: 14.3 nTPM (vital, limit 1); adipose tissue: 10.4 nTPM (manageable, limit 5); liver: 9.3 nTPM (vital, limit 1); hippocampal formation: 9.2 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 3); adrenal gland: 8.8 nTPM (vital, limit 1); hypothalamus: 8.7 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.5 nTPM (protected, limit 3); salivary gland: 8.2 nTPM (protected, limit 3); heart muscle: 7.4 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); retina: 5.2 nTPM (vital, limit 1); basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZDHHC20,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000180872,False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,DEFB112,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000180878,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.19636,0,3,partial,1.4,0.3,1.5,"retina: 1.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C11orf42,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000180934,False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"bone marrow: 50.0000% (minimum 75%, Missing); liver: 66.6667% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing)",0.0166667,-0.0333333,-0.25,9,80,unavailable,0.2,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR56A1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000180938,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"kidney: 68.6275% (minimum 75%, Missing); retina: 66.0377% (minimum 75%, Missing)",0.0103774,0.0103774,-0.0896226,0,1,partial,1.8,1.8,1.8,"retina: 1.8 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF572,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000180974,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 71.4286% (minimum 75%, Missing); retina: 45.4545% (minimum 75%, Missing); skeletal muscle: 71.4286% (minimum 75%, Missing); skin: 55.5556% (minimum 65%, Missing); thyroid gland: 62.5000% (minimum 65%, Missing)",-0.0944444,0.133333,-0.295455,0,80,unavailable,0.6,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR52E4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000180999,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 60.2837% (minimum 75%, Missing)",0.327011,0.188502,-0.147163,0,80,unavailable,16.8,3.2,0.6,"heart muscle: 16.8 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 3); bone marrow: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C1orf105,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000181029,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 67.7159% (minimum 75%, Missing); amygdala: 64.0058% (minimum 75%, Missing); basal ganglia: 63.4076% (minimum 75%, Missing); bone marrow: 73.9003% (minimum 75%, Missing); cerebellum: 74.4304% (minimum 75%, Uncertain); cerebral cortex: 64.5208% (minimum 75%, Missing); choroid plexus: 66.7171% (minimum 75%, Missing); esophagus: 67.9507% (minimum 70%, Uncertain); heart muscle: 63.4076% (minimum 75%, Missing); hippocampal formation: 64.5208% (minimum 75%, Missing); hypothalamus: 67.4312% (minimum 75%, Missing); kidney: 70.5600% (minimum 75%, Missing); liver: 64.4737% (minimum 75%, Uncertain); midbrain: 68.5315% (minimum 75%, Missing); pancreas: 73.0132% (minimum 75%, Missing); skeletal muscle: 61.9382% (minimum 75%, Missing); spinal cord: 73.4694% (minimum 75%, Missing)",0.017676,-0.0204931,-0.130618,0,1,partial,108.4,83.2,87.8,"skeletal muscle: 108.4 nTPM (vital, limit 1); basal ganglia: 101.8 nTPM (vital, limit 1); heart muscle: 101.8 nTPM (vital, limit 1); amygdala: 99.2 nTPM (vital, limit 1); liver: 97.2 nTPM (vital, limit 1); hippocampal formation: 97 nTPM (vital, limit 1); cerebral cortex: 97 nTPM (vital, limit 1); choroid plexus: 88 nTPM (vital, limit 1); skin: 87.8 nTPM (manageable, limit 5); hypothalamus: 85.2 nTPM (vital, limit 1); adrenal gland: 84.1 nTPM (vital, limit 1); esophagus: 83.2 nTPM (protected, limit 3); midbrain: 81 nTPM (vital, limit 1); kidney: 73.6 nTPM (vital, limit 1); pancreas: 65.2 nTPM (vital, limit 1); spinal cord: 63.7 nTPM (vital, limit 1); salivary gland: 62.9 nTPM (protected, limit 3); bone marrow: 62.3 nTPM (vital, limit 1); cerebellum: 60.6 nTPM (vital, limit 1); spleen: 59.1 nTPM (manageable, limit 5); adipose tissue: 57.1 nTPM (manageable, limit 5); pituitary gland: 56.8 nTPM (vital, limit 1); stomach: 55.9 nTPM (protected, limit 3); thyroid gland: 54.3 nTPM (manageable, limit 5); urinary bladder: 53.7 nTPM (protected, limit 3); colon: 51.4 nTPM (protected, limit 3); small intestine: 47.2 nTPM (vital, limit 1); lung: 34.8 nTPM (vital, limit 1); duodenum: 26.7 nTPM (vital, limit 1); tongue: 26.1 nTPM (protected, limit 3); lymph node: 22.8 nTPM (protected, limit 3); parathyroid gland: 19.1 nTPM (protected, limit 3); thymus: 16.3 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); retina: 8.7 nTPM (vital, limit 1); rectum: 8.1 nTPM (protected, limit 3)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRAPPC5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000181195,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 25.5657% (minimum 75%, Missing); basal ganglia: 14.5139% (minimum 75%, Missing); hypothalamus: 60.3755% (minimum 75%, Missing)",0.348408,0.149018,-0.604861,0,7,partial,738.6,22.3,8.3,"basal ganglia: 738.6 nTPM (vital, limit 1); adrenal gland: 365.1 nTPM (vital, limit 1); hypothalamus: 82.3 nTPM (vital, limit 1); cerebellum: 31.6 nTPM (vital, limit 6); spinal cord: 25.5 nTPM (vital, limit 1); heart muscle: 24.7 nTPM (vital, limit 6); colon: 22.3 nTPM (protected, limit 3); amygdala: 20.2 nTPM (vital, limit 1); pituitary gland: 16.6 nTPM (vital, limit 1); cerebral cortex: 7.2 nTPM (vital, limit 6); tongue: 5.1 nTPM (protected, limit 3); hippocampal formation: 4.6 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); adrenal gland / medullary cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced),78,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PENK,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000181322,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 45.8221% (minimum 75%, Missing); hypothalamus: 72.0339% (minimum 75%, Missing); retina: 70.2479% (minimum 75%, Missing)",0.289227,0.271429,-0.291779,0,12,partial,20.1,1.6,1.1,"choroid plexus: 20.1 nTPM (vital, limit 1); retina: 7.2 nTPM (vital, limit 1); hypothalamus: 6.6 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 4.7 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),83,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NME9,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000181323,True,compatible,,True,True,True,,0.35,0.3,0.247015,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPEM1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000181371,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR5M8,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000181433,True,compatible,,True,True,True,,0.35,0.3,0.209184,0,6,partial,0.2,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SAGE1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000181450,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.1212% (minimum 65%, Missing); adrenal gland: 57.7465% (minimum 75%, Missing); amygdala: 73.2143% (minimum 75%, Missing); basal ganglia: 74.5455% (minimum 75%, Missing); bone marrow: 53.9474% (minimum 75%, Missing); cerebellum: 69.4915% (minimum 75%, Missing); cerebral cortex: 51.8987% (minimum 75%, Missing); colon: 59.4203% (minimum 70%, Missing); duodenum: 65.0794% (minimum 75%, Missing); esophagus: 67.2131% (minimum 70%, Missing); heart muscle: 69.4915% (minimum 75%, Missing); hippocampal formation: 74.5455% (minimum 75%, Missing); kidney: 62.1212% (minimum 75%, Missing); liver: 66.1290% (minimum 75%, Missing); lung: 56.9444% (minimum 75%, Missing); lymph node: 48.2353% (minimum 70%, Missing); midbrain: 73.2143% (minimum 75%, Missing); pancreas: 56.1644% (minimum 75%, Missing); parathyroid gland: 64.0625% (minimum 70%, Missing); pituitary gland: 73.2143% (minimum 75%, Missing); rectum: 51.2500% (minimum 70%, Missing); retina: 41.8367% (minimum 75%, Missing); salivary gland: 60.2941% (minimum 70%, Missing); skeletal muscle: 74.5455% (minimum 75%, Missing); small intestine: 65.0794% (minimum 75%, Missing); smooth muscle: 64.0625% (minimum 75%, Missing); spinal cord: 69.4915% (minimum 75%, Missing); spleen: 53.2468% (minimum 65%, Missing); stomach: 56.1644% (minimum 70%, Missing); thymus: 48.8095% (minimum 65%, Missing); thyroid gland: 43.6170% (minimum 65%, Missing); tongue: 61.1940% (minimum 70%, Missing); urinary bladder: 66.1290% (minimum 70%, Missing)",-0.21383,-0.217647,-0.331633,0,80,unavailable,5.7,4.4,5.3,"retina: 5.7 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); lymph node: 4.4 nTPM (protected, limit 3); rectum: 3.9 nTPM (protected, limit 3); cerebral cortex: 3.8 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 3); pancreas: 3.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); heart muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF678,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000181552,True,compatible,,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EDDM3B,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000181562,True,compatible,,True,True,True,,0.35,0.3,0.249678,0,5,partial,0.7,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EDDM3A,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,True,True,True,True,True,unchanged,
ENSG00000181609,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR52D1,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000181616,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR52H1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000181626,True,compatible,,True,True,True,,0.35,0.3,0.04,0,3,partial,0.9,0.2,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ANKRD62,current_adaptive,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,True,True,True,False,gained,selectivity_revised
ENSG00000181722,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"liver: 73.9130% (minimum 75%, Missing); retina: 64.0167% (minimum 75%, Missing); skeletal muscle: 65.6652% (minimum 75%, Missing); tongue: 64.0167% (minimum 70%, Missing)",0.107426,-0.0598326,-0.109833,0,3,partial,8.6,8.6,4.9,"retina: 8.6 nTPM (vital, limit 1); tongue: 8.6 nTPM (protected, limit 3); skeletal muscle: 8 nTPM (vital, limit 1); liver: 5.4 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.7 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); bone marrow: 3.1 nTPM (vital, limit 2); smooth muscle: 2.8 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); colon / endothelial cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZBTB20,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000181781,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 74.0260% (minimum 75%, Missing)",0.320213,0.291304,-0.00974026,0,80,unavailable,8,0.2,0.7,"skeletal muscle: 8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CIMAP1D,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000181786,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ACTL9,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000181827,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 61.4035% (minimum 75%, Missing); bone marrow: 52.6316% (minimum 75%, Missing); cerebellum: 56.0000% (minimum 75%, Missing); cerebral cortex: 61.9469% (minimum 75%, Missing); duodenum: 61.4035% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); liver: 72.9167% (minimum 75%, Missing); lung: 69.3069% (minimum 75%, Missing); lymph node: 56.0000% (minimum 70%, Missing); pancreas: 72.9167% (minimum 75%, Missing); parathyroid gland: 64.2202% (minimum 70%, Missing); pituitary gland: 72.9167% (minimum 75%, Missing); rectum: 69.3069% (minimum 70%, Missing); retina: 44.3038% (minimum 75%, Missing); skeletal muscle: 50.3597% (minimum 75%, Missing); skin: 52.6316% (minimum 65%, Missing); small intestine: 67.3077% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spleen: 61.4035% (minimum 65%, Missing); thymus: 38.4615% (minimum 65%, Missing); tongue: 55.5556% (minimum 70%, Missing); urinary bladder: 67.3077% (minimum 70%, Missing)",-0.265385,-0.144444,-0.306962,0,11,partial,8.8,5.6,11.2,"thymus: 11.2 nTPM (manageable, limit 5); retina: 8.8 nTPM (vital, limit 1); skeletal muscle: 6.9 nTPM (vital, limit 1); bone marrow: 6.3 nTPM (vital, limit 1); skin: 6.3 nTPM (manageable, limit 5); tongue: 5.6 nTPM (protected, limit 3); lymph node: 5.5 nTPM (protected, limit 3); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); duodenum: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 3); smooth muscle: 3.5 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); urinary bladder: 3.4 nTPM (protected, limit 3); small intestine: 3.4 nTPM (vital, limit 1); rectum: 3.1 nTPM (protected, limit 3); lung: 3.1 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 2); pancreas: 2.6 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / granular cells - nucleus: High (Approved); cerebellum / molecular layer cells - nucleus: High (Approved); cerebellum / white matter cells - nucleus: High (Approved); cerebral cortex / glial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / collecting ducts: Medium (Approved); kidney / distal tubules: Medium (Approved); kidney / proximal tubules (cell body): Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: Medium (Approved); lung / endothelial cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: High (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / goblet cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RFX7,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000181867,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FTMT,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000181873,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6486% (minimum 60%, Approved); adrenal gland: 40.0000% (minimum 75%, Missing); amygdala: 60.0000% (minimum 75%, Missing); basal ganglia: 58.0645% (minimum 75%, Missing); bone marrow: 30.5085% (minimum 75%, Missing); cerebellum: 43.9024% (minimum 70%, Approved); cerebral cortex: 52.9412% (minimum 70%, Approved); choroid plexus: 54.5455% (minimum 75%, Missing); colon: 51.4286% (minimum 70%, Missing); duodenum: 52.9412% (minimum 70%, Approved); esophagus: 52.9412% (minimum 65%, Approved); heart muscle: 36.0000% (minimum 70%, Approved); hippocampal formation: 62.0690% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); kidney: 48.6486% (minimum 75%, Missing); liver: 40.0000% (minimum 70%, Approved); lung: 48.6486% (minimum 75%, Missing); lymph node: 52.9412% (minimum 70%, Missing); midbrain: 62.0690% (minimum 75%, Missing); pancreas: 39.1304% (minimum 75%, Missing); parathyroid gland: 46.1538% (minimum 70%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); rectum: 58.0645% (minimum 70%, Missing); retina: 60.0000% (minimum 75%, Missing); salivary gland: 51.4286% (minimum 70%, Missing); skeletal muscle: 23.6842% (minimum 70%, Approved); skin: 38.2979% (minimum 65%, Missing); small intestine: 52.9412% (minimum 75%, Missing); smooth muscle: 52.9412% (minimum 70%, Approved); spinal cord: 66.6667% (minimum 75%, Missing); spleen: 51.4286% (minimum 65%, Missing); stomach: 48.6486% (minimum 70%, Missing); thymus: 58.0645% (minimum 65%, Missing); thyroid gland: 58.0645% (minimum 60%, Approved); tongue: 32.1429% (minimum 70%, Missing); urinary bladder: 58.0645% (minimum 65%, Approved)",-0.267021,-0.378571,-0.463158,0,3,partial,5.8,3.8,2.9,"skeletal muscle: 5.8 nTPM (vital, limit 2); bone marrow: 4.1 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 3); heart muscle: 3.2 nTPM (vital, limit 2); pancreas: 2.8 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 2); adrenal gland: 2.7 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 2); lung: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 2 / chondrocytes: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IBA57,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000181896,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 43.4599% (minimum 75%, Missing); colon: 69.1275% (minimum 70%, Missing); esophagus: 60.5882% (minimum 70%, Missing); kidney: 72.0280% (minimum 75%, Missing); lymph node: 27.7628% (minimum 70%, Missing); retina: 71.5278% (minimum 75%, Missing); small intestine: 56.5934% (minimum 75%, Missing); spleen: 49.0476% (minimum 65%, Missing); thymus: 29.5129% (minimum 65%, Missing); urinary bladder: 65.6051% (minimum 70%, Missing)",-0.354871,-0.422372,-0.315401,0,80,unavailable,13.4,26.8,24.6,"lymph node: 26.8 nTPM (protected, limit 3); thymus: 24.6 nTPM (manageable, limit 5); bone marrow: 13.4 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); small intestine: 7.9 nTPM (vital, limit 1); esophagus: 6.7 nTPM (protected, limit 3); urinary bladder: 5.4 nTPM (protected, limit 3); colon: 4.6 nTPM (protected, limit 3); stomach: 4.4 nTPM (protected, limit 3); rectum: 4.4 nTPM (protected, limit 3); retina: 4.1 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); duodenum: 3.1 nTPM (vital, limit 1); choroid plexus: 3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); liver: 3 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF101,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000181904,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.7758% (minimum 60%, Approved); adrenal gland: 52.8195% (minimum 75%, Missing); amygdala: 59.5339% (minimum 75%, Missing); basal ganglia: 55.7540% (minimum 75%, Missing); bone marrow: 53.2197% (minimum 75%, Missing); cerebellum: 43.9750% (minimum 75%, Missing); cerebral cortex: 53.2197% (minimum 75%, Missing); colon: 57.8189% (minimum 70%, Missing); duodenum: 56.6532% (minimum 75%, Missing); esophagus: 58.0579% (minimum 70%, Missing); heart muscle: 59.9147% (minimum 75%, Missing); hippocampal formation: 58.0579% (minimum 75%, Missing); hypothalamus: 58.9099% (minimum 75%, Missing); kidney: 41.5066% (minimum 75%, Missing); liver: 40.1429% (minimum 75%, Missing); lung: 55.8648% (minimum 75%, Missing); lymph node: 63.8636% (minimum 70%, Missing); midbrain: 60.8225% (minimum 75%, Missing); pancreas: 68.7042% (minimum 75%, Missing); parathyroid gland: 52.0370% (minimum 70%, Missing); pituitary gland: 65.1972% (minimum 75%, Missing); rectum: 61.2200% (minimum 70%, Missing); retina: 60.0427% (minimum 75%, Missing); salivary gland: 61.2200% (minimum 70%, Missing); skeletal muscle: 57.5820% (minimum 75%, Missing); skin: 60.1713% (minimum 65%, Missing); small intestine: 62.7232% (minimum 75%, Missing); smooth muscle: 52.2305% (minimum 75%, Missing); spinal cord: 50.0891% (minimum 75%, Missing); spleen: 63.4312% (minimum 65%, Missing); stomach: 64.1553% (minimum 70%, Missing); thyroid gland: 49.2982% (minimum 65%, Missing); tongue: 52.3277% (minimum 70%, Missing); urinary bladder: 56.7677% (minimum 70%, Missing)",-0.157018,-0.17963,-0.348571,0,3,partial,41.9,25.9,28.9,"liver: 41.9 nTPM (vital, limit 1); kidney: 39.6 nTPM (vital, limit 1); cerebellum: 35.8 nTPM (vital, limit 1); thyroid gland: 28.9 nTPM (manageable, limit 5); spinal cord: 28 nTPM (vital, limit 1); parathyroid gland: 25.9 nTPM (protected, limit 3); smooth muscle: 25.7 nTPM (vital, limit 1); tongue: 25.6 nTPM (protected, limit 3); adrenal gland: 25.1 nTPM (vital, limit 1); bone marrow: 24.7 nTPM (vital, limit 1); cerebral cortex: 24.7 nTPM (vital, limit 1); adipose tissue: 23.2 nTPM (manageable, limit 10); basal ganglia: 22.3 nTPM (vital, limit 1); lung: 22.2 nTPM (vital, limit 1); duodenum: 21.5 nTPM (vital, limit 1); urinary bladder: 21.4 nTPM (protected, limit 3); skeletal muscle: 20.7 nTPM (vital, limit 1); colon: 20.5 nTPM (protected, limit 3); hippocampal formation: 20.3 nTPM (vital, limit 1); esophagus: 20.3 nTPM (protected, limit 3); hypothalamus: 19.6 nTPM (vital, limit 1); amygdala: 19.1 nTPM (vital, limit 1); heart muscle: 18.8 nTPM (vital, limit 1); retina: 18.7 nTPM (vital, limit 1); skin: 18.6 nTPM (manageable, limit 5); midbrain: 18.1 nTPM (vital, limit 1); salivary gland: 17.8 nTPM (protected, limit 3); rectum: 17.8 nTPM (protected, limit 3); small intestine: 16.7 nTPM (vital, limit 1); spleen: 16.2 nTPM (manageable, limit 5); lymph node: 15.9 nTPM (protected, limit 3); stomach: 15.7 nTPM (protected, limit 3); pituitary gland: 15 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); pancreas: 12.8 nTPM (vital, limit 1); choroid plexus: 7.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C5orf24,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000181961,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR4A16,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000181965,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0.7,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NEUROG1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000182035,True,compatible,,True,True,True,,0.331132,0.3,0.244264,0,80,unavailable,0.3,0,1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ADIG,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000182050,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 63.0137% (minimum 75%, Missing); basal ganglia: 51.1111% (minimum 75%, Missing); cerebral cortex: 56.7901% (minimum 70%, Approved); heart muscle: 74.1935% (minimum 75%, Missing); hippocampal formation: 73.0159% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); midbrain: 69.6970% (minimum 75%, Missing); pituitary gland: 59.7403% (minimum 75%, Missing); thyroid gland: 44.2308% (minimum 60%, Approved)",-0.157692,0.22,-0.238889,0,4,partial,4.4,0.4,5.8,"basal ganglia: 4.4 nTPM (vital, limit 1); cerebral cortex: 3.5 nTPM (vital, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); colon / glandular cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved),50,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin 1 / keratinocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MGAT4C,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000182053,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TRIM49B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000182083,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 57.1429% (minimum 75%, Missing)",0.35,0.3,-0.178571,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR6B2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000182111,True,compatible,,True,True,True,,0.35,0.3,0.05,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF716,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000182134,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 62.1387% (minimum 75%, Missing); cerebral cortex: 74.1379% (minimum 75%, Missing); hypothalamus: 74.9129% (minimum 75%, Missing); parathyroid gland: 42.4901% (minimum 70%, Missing); retina: 69.8052% (minimum 75%, Missing)",0.036901,-0.275099,-0.128613,0,3,partial,13.1,29.1,9.8,"parathyroid gland: 29.1 nTPM (protected, limit 3); cerebellum: 13.1 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); retina: 9.3 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 7.2 nTPM (vital, limit 1); thyroid gland: 7.1 nTPM (manageable, limit 5); salivary gland: 6.8 nTPM (protected, limit 3); spinal cord: 6.6 nTPM (vital, limit 1); midbrain: 6.6 nTPM (vital, limit 1); spleen: 6.1 nTPM (manageable, limit 5); hippocampal formation: 5.9 nTPM (vital, limit 1); lymph node: 5.8 nTPM (protected, limit 3); amygdala: 5.8 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 3); pituitary gland: 4.5 nTPM (vital, limit 1); lung: 4.2 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); kidney: 3.9 nTPM (vital, limit 1); liver: 3.5 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); colon: 3.1 nTPM (protected, limit 3); adrenal gland: 3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TDRKH,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000182170,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,MRGPRG,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000182185,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 54.3750% (minimum 75%, Missing); lymph node: 64.9254% (minimum 70%, Missing); parathyroid gland: 64.9254% (minimum 70%, Missing); salivary gland: 40.6542% (minimum 70%, Missing); smooth muscle: 67.4419% (minimum 75%, Missing); spinal cord: 71.9008% (minimum 75%, Missing); thymus: 60.0000% (minimum 65%, Missing)",-0.05,-0.293458,-0.20625,0,7,partial,7.3,12.7,5.8,"salivary gland: 12.7 nTPM (protected, limit 3); bone marrow: 7.3 nTPM (vital, limit 1); thymus: 5.8 nTPM (manageable, limit 5); lymph node: 4.7 nTPM (protected, limit 3); parathyroid gland: 4.7 nTPM (protected, limit 3); smooth muscle: 4.2 nTPM (vital, limit 1); esophagus: 3.6 nTPM (protected, limit 3); urinary bladder: 3.5 nTPM (protected, limit 3); spinal cord: 3.4 nTPM (vital, limit 1); retina: 2.9 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: High (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: High (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: High (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: High (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: High (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: High (Enhanced); nasopharynx / respiratory epithelial cells: High (Enhanced); oral mucosa / squamous epithelial cells: High (Enhanced); pancreas / exocrine glandular cells: High (Enhanced); pancreas / pancreatic endocrine cells: High (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: High (Enhanced); skeletal muscle / myocytes: High (Enhanced); skin 1 / fibroblasts: High (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: High (Enhanced); soft tissue 1 / fibroblasts: High (Enhanced); soft tissue 1 / peripheral nerve: High (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: High (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RAD51B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000182223,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"midbrain: 66.6667% (minimum 75%, Missing)",0.283333,0.175,-0.0833333,0,80,unavailable,0.7,0.2,0.1,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZAR1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000182256,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 73.1707% (minimum 75%, Missing); retina: 25.4958% (minimum 75%, Missing)",0.215385,0.2375,-0.495042,0,3,partial,26.3,0.8,1.4,"retina: 26.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / processes in white matter: Low (Approved); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GABRG3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000182261,False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"skin: 22.5806% (minimum 65%, Missing)",-0.424194,0.3,0.125,0,2,partial,0.2,0,4.8,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NLRP10,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000182264,True,compatible,,True,True,True,,0.35,0.3,0.244595,0,1,partial,1.5,0.9,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IZUMO1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,False,gained,selectivity_revised
ENSG00000182308,True,compatible,,True,True,True,,0.35,0.3,0.22166,0,2,partial,1.1,0.2,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DCAF4L1,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,False,gained,selectivity_revised
ENSG00000182315,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.238889,0.3,0.138889,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,MBD3L3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000182324,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.9048% (minimum 65%, Missing); amygdala: 56.5217% (minimum 75%, Missing); basal ganglia: 22.4138% (minimum 75%, Missing); bone marrow: 39.3939% (minimum 75%, Missing); cerebellum: 43.3333% (minimum 75%, Missing); cerebral cortex: 43.3333% (minimum 75%, Missing); esophagus: 52.0000% (minimum 70%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 54.1667% (minimum 75%, Missing); kidney: 61.9048% (minimum 75%, Missing); liver: 59.0909% (minimum 75%, Missing); lung: 65.0000% (minimum 75%, Missing); midbrain: 52.0000% (minimum 75%, Missing); pancreas: 68.4211% (minimum 75%, Missing); pituitary gland: 59.0909% (minimum 75%, Missing); retina: 2.2337% (minimum 75%, Missing); salivary gland: 68.4211% (minimum 70%, Missing); skeletal muscle: 44.8276% (minimum 75%, Missing); skin: 38.2353% (minimum 65%, Missing); small intestine: 72.2222% (minimum 75%, Missing); spinal cord: 68.4211% (minimum 75%, Missing); thyroid gland: 52.0000% (minimum 65%, Missing); urinary bladder: 68.4211% (minimum 70%, Missing)",-0.267647,-0.18,-0.727663,0,80,unavailable,56.9,1.2,2.1,"retina: 56.9 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KCNJ14,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000182405,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 68.0000% (minimum 75%, Missing); amygdala: 68.0000% (minimum 75%, Missing); basal ganglia: 62.9630% (minimum 75%, Missing); bone marrow: 38.6364% (minimum 75%, Missing); cerebellum: 60.7143% (minimum 75%, Missing); cerebral cortex: 45.9459% (minimum 75%, Missing); choroid plexus: 68.0000% (minimum 75%, Missing); colon: 65.3846% (minimum 70%, Missing); duodenum: 60.7143% (minimum 75%, Missing); heart muscle: 54.8387% (minimum 75%, Missing); hippocampal formation: 65.3846% (minimum 75%, Missing); hypothalamus: 60.7143% (minimum 75%, Missing); kidney: 62.9630% (minimum 75%, Missing); liver: 56.6667% (minimum 75%, Missing); lung: 70.8333% (minimum 75%, Missing); lymph node: 45.9459% (minimum 70%, Missing); midbrain: 62.9630% (minimum 75%, Missing); pancreas: 65.3846% (minimum 75%, Missing); parathyroid gland: 53.1250% (minimum 70%, Missing); pituitary gland: 73.9130% (minimum 75%, Missing); rectum: 60.7143% (minimum 70%, Missing); retina: 42.5000% (minimum 75%, Missing); skeletal muscle: 25.0000% (minimum 75%, Missing); skin: 53.1250% (minimum 65%, Missing); small intestine: 60.7143% (minimum 75%, Missing); smooth muscle: 73.9130% (minimum 75%, Missing); spinal cord: 62.9630% (minimum 75%, Missing); spleen: 54.8387% (minimum 65%, Missing); stomach: 54.8387% (minimum 70%, Missing); thymus: 56.6667% (minimum 65%, Missing); thyroid gland: 62.9630% (minimum 65%, Missing); tongue: 58.6207% (minimum 70%, Missing)",-0.11875,-0.240541,-0.5,0,80,unavailable,5.1,2,1.5,"skeletal muscle: 5.1 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.3 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PGBD4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000182459,True,compatible,,True,True,True,,0.346678,0.3,0.25,0,2,partial,0,0,0.1,,,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX19,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000182481,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 67.4635% (minimum 75%, Missing)",0.0376481,0.0426901,-0.0753652,0,11,partial,98,70.4,92.3,"bone marrow: 98 nTPM (vital, limit 1); thymus: 92.3 nTPM (manageable, limit 5); lymph node: 70.4 nTPM (protected, limit 3); esophagus: 40.2 nTPM (protected, limit 3); urinary bladder: 37.2 nTPM (protected, limit 3); rectum: 34.7 nTPM (protected, limit 3); smooth muscle: 33.3 nTPM (vital, limit 6); colon: 29.7 nTPM (protected, limit 3); spleen: 27.6 nTPM (manageable, limit 5); cerebral cortex: 26.4 nTPM (vital, limit 1); duodenum: 25.4 nTPM (vital, limit 1); heart muscle: 23.1 nTPM (vital, limit 1); hypothalamus: 23 nTPM (vital, limit 1); small intestine: 22.7 nTPM (vital, limit 1); liver: 22.4 nTPM (vital, limit 1); retina: 21.5 nTPM (vital, limit 1); skin: 20.5 nTPM (manageable, limit 5); hippocampal formation: 20 nTPM (vital, limit 1); stomach: 18.5 nTPM (protected, limit 3); amygdala: 17.8 nTPM (vital, limit 1); lung: 17.3 nTPM (vital, limit 1); midbrain: 16.4 nTPM (vital, limit 1); tongue: 16.1 nTPM (protected, limit 3); kidney: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); adrenal gland: 15.4 nTPM (vital, limit 1); pituitary gland: 15.2 nTPM (vital, limit 1); basal ganglia: 15.2 nTPM (vital, limit 1); salivary gland: 15 nTPM (protected, limit 3); skeletal muscle: 14.3 nTPM (vital, limit 1); thyroid gland: 10.6 nTPM (manageable, limit 5); parathyroid gland: 10.3 nTPM (protected, limit 3); cerebellum: 10.3 nTPM (vital, limit 1); pancreas: 9.7 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / ciliated cells (cell body): Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in basal layer: Low (Enhanced); skin 1 / cells in spinous layer: Low (Enhanced); skin 1 / fibrohistiocytic cells: High (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Low (Enhanced); skin 2 / lymphocytes: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),86,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in spinous layer; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in basal layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; skin 2 / lymphocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KPNA2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000182583,True,compatible,,True,True,True,,0.35,0.3,0.237842,0,7,partial,0.4,0.1,0.1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,appendix; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,VCX,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000182613,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 33.3333% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing); small intestine: 66.6667% (minimum 75%, Missing)",0.0166667,0.3,-0.416667,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR2V2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000182645,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.291667,0.0486577,0,80,unavailable,3,0.1,0,"retina: 3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC172,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000182652,False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR4Q3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000182752,True,compatible,,True,True,True,,0.338701,0.281767,0.235915,0,2,partial,4,8.8,3.9,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PAPPA,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,"Bruggeman 2018;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,True,True,True,False,gained,selectivity_revised
ENSG00000182791,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.293662,0.224138,0.155405,0,80,unavailable,1.4,1.1,0.8,"retina: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC87,current_adaptive,True,False,False,False,10.1136/jitc-2023-007935,Carter 2023,False,False,False,False,False,unchanged,
ENSG00000182793,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GSTA5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000182798,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"pancreas: 45.7143% (minimum 75%, Missing)",0.291176,0.1,-0.292857,0,80,unavailable,1.9,0.4,0.1,"pancreas: 1.9 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,MAGEB17,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000182890,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.253614,0.261538,0.0478723,0,1,partial,3.8,0.6,1.6,"liver: 3.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: High (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GLUD2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000182896,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TMEM95,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000182898,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"skin: 12.5000% (minimum 50%, Enhanced)",-0.375,0.3,0.25,0,1,partial,0,0,0.7,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TCHHL1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000182901,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 43.3333% (minimum 60%, Enhanced); amygdala: 17.9724% (minimum 75%, Missing); basal ganglia: 9.4891% (minimum 75%, Missing); cerebellum: 8.4416% (minimum 75%, Missing); cerebral cortex: 8.2105% (minimum 75%, Missing); hippocampal formation: 14.7727% (minimum 75%, Missing); hypothalamus: 19.6970% (minimum 75%, Missing); midbrain: 29.5455% (minimum 75%, Missing); pituitary gland: 58.2090% (minimum 75%, Missing); retina: 48.7500% (minimum 75%, Missing); spinal cord: 42.3913% (minimum 75%, Missing)",0.35,0.2625,-0.667895,0,5,partial,43.6,0.9,0.2,"cerebral cortex: 43.6 nTPM (vital, limit 1); cerebellum: 42.3 nTPM (vital, limit 1); basal ganglia: 37.2 nTPM (vital, limit 1); hippocampal formation: 22.5 nTPM (vital, limit 1); amygdala: 17.8 nTPM (vital, limit 1); hypothalamus: 15.9 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); spinal cord: 5.3 nTPM (vital, limit 1); retina: 4.1 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / molecular layer - neuropil: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / synaptic glomeruli - core: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RGS7,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000182950,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.277966,0.227966,0.133065,0,80,unavailable,2.9,1.7,1.7,"choroid plexus: 2.9 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CIMAP1C,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000182968,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 16.6667% (minimum 75%, Missing); basal ganglia: 17.0213% (minimum 75%, Missing); cerebellum: 30.7692% (minimum 75%, Missing); cerebral cortex: 19.0476% (minimum 75%, Missing); hippocampal formation: 25.0000% (minimum 75%, Missing); hypothalamus: 12.9032% (minimum 75%, Missing); midbrain: 28.5714% (minimum 75%, Missing); spinal cord: 57.1429% (minimum 75%, Missing)",0.238889,0.188889,-0.620968,0,80,unavailable,5.4,0.1,0.1,"hypothalamus: 5.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); basal ganglia: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SOX1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000182974,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR4M2B,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000182993,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 71.1443% (minimum 75%, Missing); retina: 69.7561% (minimum 75%, Missing)",0.167143,0.188199,-0.052439,0,80,unavailable,6.2,1.8,3.2,"retina: 6.2 nTPM (vital, limit 1); liver: 5.8 nTPM (vital, limit 1); adrenal gland: 4.6 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C12orf60,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000183024,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR1G1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000183034,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 17.4468% (minimum 70%, Missing); rectum: 28.4722% (minimum 70%, Missing)",0.303488,-0.525532,0.00925926,0,80,unavailable,1.3,19.4,0.2,"colon: 19.4 nTPM (protected, limit 3); rectum: 10.3 nTPM (protected, limit 3); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OTOP2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000183035,True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CYLC1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000183066,True,compatible,,True,True,True,,0.344253,0.294253,0.211111,0,3,partial,0.7,0.5,0.6,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,WBP2NL,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000183137,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 71.6714% (minimum 75%, Missing); choroid plexus: 69.3151% (minimum 75%, Missing); liver: 72.2857% (minimum 75%, Missing); parathyroid gland: 60.8173% (minimum 70%, Missing); retina: 70.0831% (minimum 75%, Missing); smooth muscle: 70.8683% (minimum 75%, Missing); thymus: 64.3766% (minimum 65%, Missing)",-0.0062341,-0.0918269,-0.0568493,0,3,partial,11.2,16.3,14,"parathyroid gland: 16.3 nTPM (protected, limit 3); thymus: 14 nTPM (manageable, limit 5); choroid plexus: 11.2 nTPM (vital, limit 1); retina: 10.8 nTPM (vital, limit 1); rectum: 10.5 nTPM (protected, limit 3); smooth muscle: 10.4 nTPM (vital, limit 1); adipose tissue: 10.2 nTPM (manageable, limit 5); bone marrow: 10 nTPM (vital, limit 1); liver: 9.7 nTPM (vital, limit 1); lymph node: 8.6 nTPM (protected, limit 3); thyroid gland: 8.4 nTPM (manageable, limit 5); duodenum: 8.4 nTPM (vital, limit 1); spinal cord: 8.4 nTPM (vital, limit 1); colon: 8.2 nTPM (protected, limit 3); kidney: 7.7 nTPM (vital, limit 1); small intestine: 7.6 nTPM (vital, limit 1); spleen: 7.5 nTPM (manageable, limit 5); heart muscle: 7.4 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); pancreas: 7.1 nTPM (vital, limit 1); stomach: 7.1 nTPM (protected, limit 3); cerebral cortex: 6.9 nTPM (vital, limit 1); skin: 6.5 nTPM (manageable, limit 5); lung: 6.4 nTPM (vital, limit 1); tongue: 6.3 nTPM (protected, limit 3); urinary bladder: 6.2 nTPM (protected, limit 3); esophagus: 6 nTPM (protected, limit 3); midbrain: 5.9 nTPM (vital, limit 1); skeletal muscle: 5.8 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); hippocampal formation: 5.3 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); salivary gland: 5.1 nTPM (protected, limit 3); hypothalamus: 4.8 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); cerebellum: 3.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CEP57L1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000183166,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 22.1429% (minimum 75%, Missing); amygdala: 26.9565% (minimum 75%, Missing); basal ganglia: 14.7619% (minimum 75%, Missing); cerebellum: 5.1926% (minimum 75%, Missing); cerebral cortex: 10.5085% (minimum 75%, Missing); hippocampal formation: 20.9459% (minimum 75%, Missing); hypothalamus: 28.4404% (minimum 75%, Missing); midbrain: 21.6783% (minimum 75%, Missing); retina: 63.2653% (minimum 75%, Missing); skin: 48.4375% (minimum 65%, Missing); spinal cord: 15.1961% (minimum 75%, Missing); thymus: 11.3971% (minimum 65%, Missing)",-0.536029,0.26875,-0.698074,0,3,partial,56.6,0.1,24.1,"cerebellum: 56.6 nTPM (vital, limit 1); cerebral cortex: 26.4 nTPM (vital, limit 1); thymus: 24.1 nTPM (manageable, limit 5); basal ganglia: 17.9 nTPM (vital, limit 1); spinal cord: 17.3 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); adrenal gland: 10.9 nTPM (vital, limit 1); amygdala: 8.4 nTPM (vital, limit 1); hypothalamus: 7.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); rectum / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; gallbladder; gallbladder / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CALN1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000183185,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"retina: 1.1628% (minimum 75%, Missing)",0.35,0.3,-0.738372,0,80,unavailable,8.5,0,0,"retina: 8.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,GABRR3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000183206,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,POTEC,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000183246,True,compatible,,True,True,True,,0.311538,0.3,0.25,0,7,partial,0,0,0.2,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;thymic_function_review,spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RIMBP3C,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000183269,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR52E8,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000183304,True,compatible,,True,True,True,,0.326744,0.276744,0.09,0,80,unavailable,0.8,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM9A,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000183305,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEA2B,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000183313,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR52L1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000183318,True,compatible,,True,True,True,,0.35,0.3,0.237013,0,3,partial,0.8,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPDYE4,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000183324,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.144366,0,80,unavailable,4.5,0,0,"heart muscle: 4.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,REC114,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000183396,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.337705,0.275709,0.184109,0,80,unavailable,1.7,0.6,0.3,"bone marrow: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TMEM89,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000183434,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TFDP3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000183476,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 63.8298% (minimum 70%, Missing); duodenum: 56.6038% (minimum 75%, Missing); small intestine: 62.5000% (minimum 75%, Missing)",0.35,-0.0617021,-0.183962,0,9,partial,2.3,1.7,0.1,"duodenum: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1)",colon / endocrine cells: High (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes - Microvilli: Low (Enhanced); rectum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes - Microvilli: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),73,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; appendix / endocrine cells; gallbladder; gallbladder / glandular cells; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SH2D7,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000183496,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.228378,0.257895,0.211945,0,3,partial,4,3.3,6.3,"thymus: 6.3 nTPM (manageable, limit 5); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MEX3B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000183559,True,compatible,,True,True,True,,0.35,0.3,0.246689,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C10orf120,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000183629,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GOLGA8G,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,True,True,True,True,True,unchanged,
ENSG00000183632,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.335294,0.285294,0.207143,0,80,unavailable,0.3,0.1,0.1,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TP53TG3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000183640,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 25.0000% (minimum 65%, Missing); skin: 0.3356% (minimum 65%, Missing)",-0.646644,0.3,0.25,0,80,unavailable,0,0,59.4,"skin: 59.4 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,KRTAP8-1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000183654,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348753,0.28767,0.141982,0,80,unavailable,9.7,1,0.1,"pituitary gland: 9.7 nTPM (vital, limit 1); cerebral cortex: 6 nTPM (vital, limit 1); cerebellum: 5.9 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); heart muscle: 4.8 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); amygdala: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MARCHF11,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000183668,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.7,0.3,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PSG9,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",True,True,True,True,True,unchanged,
ENSG00000183706,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR4N4,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000183753,True,compatible,,True,True,True,,0.35,0.3,0.0961538,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BPY2,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000183795,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.0961538,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,BPY2B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000183808,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.1416% (minimum 75%, Missing); bone marrow: 70.6422% (minimum 75%, Missing); cerebellum: 65.8120% (minimum 75%, Missing); cerebral cortex: 66.3793% (minimum 75%, Missing); colon: 68.1416% (minimum 70%, Missing); duodenum: 64.1667% (minimum 75%, Missing); heart muscle: 64.7059% (minimum 75%, Uncertain); kidney: 65.8120% (minimum 75%, Missing); liver: 73.3333% (minimum 75%, Missing); lung: 68.1416% (minimum 75%, Uncertain); lymph node: 49.3590% (minimum 70%, Uncertain); pancreas: 69.3694% (minimum 75%, Missing); parathyroid gland: 63.1148% (minimum 70%, Missing); pituitary gland: 68.1416% (minimum 75%, Missing); rectum: 65.8120% (minimum 70%, Missing); retina: 43.0168% (minimum 75%, Missing); salivary gland: 63.1148% (minimum 70%, Missing); skeletal muscle: 66.9565% (minimum 75%, Uncertain); small intestine: 64.7059% (minimum 75%, Missing); smooth muscle: 68.7500% (minimum 75%, Uncertain); spleen: 54.2254% (minimum 65%, Uncertain); stomach: 62.0968% (minimum 70%, Missing); thymus: 52.0270% (minimum 65%, Missing); thyroid gland: 54.2254% (minimum 65%, Missing); urinary bladder: 66.9565% (minimum 70%, Missing)",-0.12973,-0.20641,-0.319832,0,1,partial,10.2,7.9,7.1,"retina: 10.2 nTPM (vital, limit 1); lymph node: 7.9 nTPM (protected, limit 3); thymus: 7.1 nTPM (manageable, limit 5); thyroid gland: 6.5 nTPM (manageable, limit 5); spleen: 6.5 nTPM (manageable, limit 5); stomach: 4.7 nTPM (protected, limit 3); parathyroid gland: 4.5 nTPM (protected, limit 3); salivary gland: 4.5 nTPM (protected, limit 3); duodenum: 4.3 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); cerebellum: 4 nTPM (vital, limit 1); kidney: 4 nTPM (vital, limit 1); rectum: 4 nTPM (protected, limit 3); cerebral cortex: 3.9 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); urinary bladder: 3.8 nTPM (protected, limit 3); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); adrenal gland: 3.6 nTPM (vital, limit 1); smooth muscle: 3.5 nTPM (vital, limit 1); pancreas: 3.4 nTPM (vital, limit 1); esophagus: 3.2 nTPM (protected, limit 3); bone marrow: 3.2 nTPM (vital, limit 1); liver: 2.8 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RBM12B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000183831,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 69.4915% (minimum 75%, Missing); choroid plexus: 66.4865% (minimum 75%, Missing)",0.334,0.0274648,-0.0851351,0,6,partial,6.2,9,0.5,"choroid plexus: 6.2 nTPM (vital, limit 1); basal ganglia: 5.4 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); hypothalamus: 2.8 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ANKRD45,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000183833,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 46.4407% (minimum 75%, Missing); pituitary gland: 66.1836% (minimum 75%, Missing)",0.202747,0.178409,-0.285593,0,4,partial,15.8,3.9,4.5,"choroid plexus: 15.8 nTPM (vital, limit 1); pituitary gland: 7 nTPM (vital, limit 1); pancreas: 4.7 nTPM (vital, limit 3); retina: 4 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Supported); bronchus / ciliated cells (ciliary rootlets): Medium (Supported); bronchus / ciliated cells (tip of cilia): High (Supported),60,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP91,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000183840,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 39.2523% (minimum 65%, Approved); duodenum: 48.2759% (minimum 70%, Approved); kidney: 61.7647% (minimum 75%, Missing); liver: 56.7568% (minimum 70%, Approved); lung: 52.5000% (minimum 75%, Missing); pancreas: 52.5000% (minimum 70%, Approved); parathyroid gland: 46.1538% (minimum 65%, Approved); rectum: 43.2990% (minimum 65%, Approved); small intestine: 53.8462% (minimum 70%, Approved); stomach: 41.5842% (minimum 65%, Approved); urinary bladder: 62.6866% (minimum 65%, Approved)",0.157692,-0.257477,-0.225,0,1,partial,4.5,6.5,1.3,"colon: 6.5 nTPM (protected, limit 4); stomach: 5.9 nTPM (protected, limit 4); rectum: 5.5 nTPM (protected, limit 4); parathyroid gland: 4.9 nTPM (protected, limit 4); duodenum: 4.5 nTPM (vital, limit 2); lung: 3.8 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 2); small intestine: 3.6 nTPM (vital, limit 2); liver: 3.2 nTPM (vital, limit 2); kidney: 2.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GPR39,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000183850,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 74.2424% (minimum 75%, Missing)",0.0121622,0.0313433,-0.00757576,0,80,unavailable,1.7,1.8,2.5,"cerebral cortex: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF730,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,False,False,False,False,unchanged,
ENSG00000183862,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CNGA2,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000183914,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 38.5321% (minimum 75%, Missing)",0.326744,0.00263158,-0.364679,0,4,partial,20.1,10.2,0.4,"retina: 20.1 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (ciliary rootlets): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAH2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000183977,True,compatible,,True,True,True,,0.35,0.286301,0.191209,0,4,partial,1.9,0.1,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PP2D1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,False,gained,selectivity_revised
ENSG00000184032,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 6.6667% (minimum 65%, Missing)",-0.583333,0.3,0.25,0,80,unavailable,0,0,1.4,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,KRTAP20-2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000184033,True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0.2,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CTAG1B,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000184108,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRIML1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000184148,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skin: 4.8616% (minimum 65%, Missing)",-0.601384,0.16747,0.25,0,5,partial,0.1,1.1,140.9,"skin: 140.9 nTPM (manageable, limit 5)",esophagus / squamous epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; skin 1 / cells in granular layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPRR4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000184166,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"bone marrow: 40.0000% (minimum 75%, Missing); cerebral cortex: 55.5556% (minimum 75%, Missing); choroid plexus: 50.0000% (minimum 75%, Missing); duodenum: 71.4286% (minimum 75%, Missing); kidney: 58.8235% (minimum 75%, Missing); liver: 58.8235% (minimum 75%, Missing); lung: 71.4286% (minimum 75%, Missing); lymph node: 55.5556% (minimum 70%, Missing); retina: 30.3030% (minimum 75%, Missing); salivary gland: 62.5000% (minimum 70%, Missing); skeletal muscle: 62.5000% (minimum 75%, Missing); skin: 47.6190% (minimum 65%, Missing); small intestine: 71.4286% (minimum 75%, Missing); spleen: 55.5556% (minimum 65%, Missing); thyroid gland: 45.4545% (minimum 65%, Missing)",-0.195455,-0.144444,-0.44697,0,80,unavailable,2.3,0.8,1.2,"retina: 2.3 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR1D2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000184302,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 3.1250% (minimum 75%, Missing); pituitary gland: 0.3597% (minimum 75%, Missing); retina: 1.5385% (minimum 75%, Missing); skeletal muscle: 33.3333% (minimum 70%, Approved)",0.35,0.3,-0.746403,0,0,routine_complete,27.7,0,0,"pituitary gland: 27.7 nTPM (vital, limit 1); retina: 6.4 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1)",pituitary gland / cells in anterior : Medium (Approved); retina / inner nuclear layer: Medium (Approved); retina / photoreceptor cells: Low (Approved),64,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SIX6,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000184305,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.4444% (minimum 75%, Uncertain); heart muscle: 73.5294% (minimum 75%, Uncertain); kidney: 73.5294% (minimum 75%, Uncertain); retina: 43.1034% (minimum 75%, Missing)",0.13125,0.0352941,-0.318966,0,2,partial,3.3,0.9,0.7,"retina: 3.3 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCSER1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000184330,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"esophagus: 32.0988% (minimum 70%, Missing); skin: 61.9048% (minimum 65%, Missing)",-0.0309524,-0.379012,0.25,0,2,partial,0,5.5,1.6,"esophagus: 5.5 nTPM (protected, limit 3)",esophagus / squamous epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: High (Supported),51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,S100A7A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000184345,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IQCF2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000184361,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.5,0.3,0.1,,,54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA32,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000184368,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 72.3014% (minimum 75%, Missing); basal ganglia: 62.7208% (minimum 75%, Missing); cerebellum: 59.9662% (minimum 75%, Missing); cerebral cortex: 53.1437% (minimum 75%, Missing); hippocampal formation: 71.4286% (minimum 75%, Missing); hypothalamus: 62.9433% (minimum 75%, Missing); midbrain: 71.5726% (minimum 75%, Missing); retina: 71.5726% (minimum 75%, Missing)",0.291645,0.106818,-0.218563,0,4,partial,31.3,8.5,2.2,"cerebral cortex: 31.3 nTPM (vital, limit 1); cerebellum: 23.7 nTPM (vital, limit 1); basal ganglia: 21.1 nTPM (vital, limit 1); hypothalamus: 20.9 nTPM (vital, limit 1); hippocampal formation: 14.2 nTPM (vital, limit 1); midbrain: 14.1 nTPM (vital, limit 1); retina: 14.1 nTPM (vital, limit 1); amygdala: 13.6 nTPM (vital, limit 1); stomach: 8.5 nTPM (protected, limit 3); spinal cord: 6 nTPM (vital, limit 1); pituitary gland: 3.8 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Bergmann glia - cytoplasm/membrane: High (Enhanced); cerebellum / GLUC cells - cytoplasm/membrane: High (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / molecular layer cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: High (Enhanced); cerebellum / Purkinje cells - dendrites: High (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); colon / peripheral nerve/ganglion: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); soft tissue 1 / chondrocytes: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAP7D2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000184378,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.332942,0.285043,0.202479,0,1,partial,2.7,1.6,1.5,"liver: 2.7 nTPM (vital, limit 2); choroid plexus: 2.3 nTPM (vital, limit 1); kidney: 2.3 nTPM (vital, limit 2); basal ganglia: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ACTRT3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000184459,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 4.7414% (minimum 65%, Missing)",-0.602586,0.256522,0.166667,0,80,unavailable,0.2,0.1,44.2,"skin: 44.2 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BPIFC,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000184478,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR56A3,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000184502,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 6.7227% (minimum 60%, Enhanced); lung: 53.3333% (minimum 60%, Enhanced); spleen: 30.5344% (minimum 50%, Enhanced); stomach: 0.0430% (minimum 70%, Missing); thymus: 48.7805% (minimum 65%, Missing)",-0.194656,-0.69957,-0.532773,0,8,partial,55.5,9294.1,9.1,"stomach: 9294.1 nTPM (protected, limit 3); duodenum: 55.5 nTPM (vital, limit 6)",stomach 2 / glandular cells: Medium (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GAST,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000184507,True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0.2,0.1,0.2,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NUTM1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000184560,True,compatible,,True,True,True,,0.35,0.3,0.248396,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPEM2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000184571,True,compatible,,True,True,True,,0.35,0.1,0.25,0,80,unavailable,0,0.2,0,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PIWIL3,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000184599,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 37.1429% (minimum 75%, Missing); cerebellum: 67.8261% (minimum 70%, Approved); midbrain: 74.2857% (minimum 75%, Missing); retina: 14.9140% (minimum 75%, Missing)",0.337342,0.3,-0.60086,0,1,partial,44.5,0.3,0.3,"retina: 44.5 nTPM (vital, limit 1); adrenal gland: 13.2 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 2); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved),55,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TAFA3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000184602,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 29.7845% (minimum 65%, Missing); adrenal gland: 45.1056% (minimum 75%, Missing); amygdala: 17.1533% (minimum 75%, Missing); basal ganglia: 12.2587% (minimum 75%, Missing); bone marrow: 49.2662% (minimum 75%, Missing); cerebellum: 20.5420% (minimum 75%, Missing); cerebral cortex: 14.6875% (minimum 75%, Missing); choroid plexus: 61.6798% (minimum 75%, Missing); colon: 59.0452% (minimum 70%, Missing); duodenum: 72.7554% (minimum 75%, Missing); esophagus: 55.9524% (minimum 70%, Missing); heart muscle: 46.0784% (minimum 75%, Missing); hippocampal formation: 17.4074% (minimum 75%, Missing); hypothalamus: 30.4010% (minimum 75%, Missing); kidney: 62.6667% (minimum 75%, Missing); liver: 72.3077% (minimum 75%, Missing); lung: 52.9279% (minimum 75%, Missing); lymph node: 43.8433% (minimum 70%, Missing); midbrain: 17.7761% (minimum 75%, Missing); pancreas: 73.6677% (minimum 75%, Missing); pituitary gland: 61.0390% (minimum 75%, Missing); retina: 37.4204% (minimum 75%, Missing); salivary gland: 56.9007% (minimum 70%, Missing); skeletal muscle: 17.4981% (minimum 75%, Missing); skin: 62.0053% (minimum 65%, Missing); small intestine: 62.6667% (minimum 75%, Missing); smooth muscle: 69.7329% (minimum 75%, Missing); spinal cord: 31.1258% (minimum 75%, Missing); spleen: 41.0839% (minimum 65%, Missing); stomach: 63.3423% (minimum 70%, Missing); thymus: 45.8090% (minimum 65%, Missing); thyroid gland: 58.4577% (minimum 65%, Missing); tongue: 39.8305% (minimum 70%, Missing); urinary bladder: 56.9007% (minimum 70%, Missing)",-0.352155,-0.301695,-0.627413,0,2,partial,168.2,35.5,55.4,"basal ganglia: 168.2 nTPM (vital, limit 1); cerebral cortex: 136.5 nTPM (vital, limit 1); amygdala: 113.5 nTPM (vital, limit 1); hippocampal formation: 111.5 nTPM (vital, limit 1); skeletal muscle: 110.8 nTPM (vital, limit 1); midbrain: 108.7 nTPM (vital, limit 1); cerebellum: 90.9 nTPM (vital, limit 1); adipose tissue: 55.4 nTPM (manageable, limit 5); hypothalamus: 53.8 nTPM (vital, limit 1); spinal cord: 52 nTPM (vital, limit 1); retina: 39.3 nTPM (vital, limit 1); tongue: 35.5 nTPM (protected, limit 3); spleen: 33.7 nTPM (manageable, limit 5); lymph node: 30.1 nTPM (protected, limit 3); adrenal gland: 28.6 nTPM (vital, limit 1); thymus: 27.8 nTPM (manageable, limit 5); heart muscle: 27.5 nTPM (vital, limit 1); bone marrow: 24.2 nTPM (vital, limit 1); lung: 20.9 nTPM (vital, limit 1); esophagus: 18.5 nTPM (protected, limit 3); urinary bladder: 17.8 nTPM (protected, limit 3); salivary gland: 17.8 nTPM (protected, limit 3); thyroid gland: 16.7 nTPM (manageable, limit 5); colon: 16.3 nTPM (protected, limit 3); pituitary gland: 15 nTPM (vital, limit 1); choroid plexus: 14.6 nTPM (vital, limit 1); skin: 14.4 nTPM (manageable, limit 5); small intestine: 14 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); stomach: 13.6 nTPM (protected, limit 3); smooth muscle: 10.2 nTPM (vital, limit 1); parathyroid gland: 9.6 nTPM (protected, limit 3); liver: 9 nTPM (vital, limit 1); duodenum: 8.8 nTPM (vital, limit 1); pancreas: 8.4 nTPM (vital, limit 1); rectum: 5.6 nTPM (protected, limit 3)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SNN,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000184635,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 68.0851% (minimum 75%, Missing); lymph node: 56.6372% (minimum 70%, Missing); pancreas: 68.0851% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing); skin: 64.0000% (minimum 65%, Missing); smooth muscle: 62.7451% (minimum 75%, Missing); thymus: 52.0325% (minimum 65%, Missing); thyroid gland: 48.8550% (minimum 65%, Missing); urinary bladder: 67.3684% (minimum 70%, Missing)",-0.16145,-0.133628,-0.122549,0,80,unavailable,3.8,4.9,6.7,"thyroid gland: 6.7 nTPM (manageable, limit 5); thymus: 5.9 nTPM (manageable, limit 5); lymph node: 4.9 nTPM (protected, limit 3); smooth muscle: 3.8 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); urinary bladder: 3.1 nTPM (protected, limit 3); bone marrow: 3 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF93,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000184647,True,compatible,,True,True,True,,0.35,0.3,0.235401,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRSS55,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000184650,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ODF4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000184661,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 74.7036% (minimum 75%, Missing); thymus: 63.0000% (minimum 65%, Missing)",-0.02,0.0875,-0.00296443,0,13,partial,6.4,5.1,11.1,"thymus: 11.1 nTPM (manageable, limit 5); bone marrow: 6.4 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: High (Enhanced); colon / enterocytes: High (Enhanced); colon / goblet cells: Medium (Enhanced); duodenum / endocrine cells: High (Enhanced); duodenum / enterocytes: Medium (Enhanced); duodenum / goblet cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / exocrine glandular cells: Low (Enhanced); rectum / endocrine cells: High (Enhanced); rectum / enterocytes: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 2 / cells in basal layer: Low (Enhanced); small intestine / endocrine cells: High (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / goblet cells: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / endothelial cells; skin 2 / cells in basal layer; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CDCA2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000184675,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 72.4638% (minimum 75%, Missing); esophagus: 64.9351% (minimum 70%, Missing); kidney: 74.6269% (minimum 75%, Missing); liver: 70.4225% (minimum 75%, Missing); pancreas: 71.4286% (minimum 75%, Missing); skeletal muscle: 56.1798% (minimum 75%, Missing); smooth muscle: 64.9351% (minimum 75%, Missing); tongue: 25.3807% (minimum 70%, Missing)",0.0542254,-0.446193,-0.188202,0,0,routine_complete,3.9,14.7,2.1,"tongue: 14.7 nTPM (protected, limit 3); skeletal muscle: 3.9 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AMER1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000184716,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 25.5319% (minimum 75%, Missing); retina: 7.4534% (minimum 75%, Missing)",0.35,0.3,-0.675466,0,80,unavailable,14.9,0,0,"retina: 14.9 nTPM (vital, limit 1); choroid plexus: 3.5 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SERINC4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000184724,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,KRTAP6-1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000184735,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DDX53,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000184786,True,compatible,,True,True,True,,0.35,0.3,0.244382,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DYNLT2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000184814,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRR23B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000184911,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 29.2929% (minimum 75%, Missing); basal ganglia: 23.5772% (minimum 75%, Missing); cerebellum: 48.0663% (minimum 75%, Missing); cerebral cortex: 27.2727% (minimum 75%, Missing); choroid plexus: 66.9231% (minimum 75%, Missing); hippocampal formation: 33.4615% (minimum 75%, Missing); hypothalamus: 24.3697% (minimum 75%, Missing); midbrain: 48.6034% (minimum 75%, Missing); pancreas: 74.3590% (minimum 75%, Missing); pituitary gland: 26.1261% (minimum 75%, Missing); retina: 52.0958% (minimum 75%, Missing); spinal cord: 69.0476% (minimum 75%, Missing)",0.0810924,0.20625,-0.514228,0,80,unavailable,28.2,0.9,3.2,"basal ganglia: 28.2 nTPM (vital, limit 1); hypothalamus: 27 nTPM (vital, limit 1); pituitary gland: 24.6 nTPM (vital, limit 1); cerebral cortex: 23.2 nTPM (vital, limit 1); amygdala: 21 nTPM (vital, limit 1); hippocampal formation: 17.3 nTPM (vital, limit 1); cerebellum: 9.4 nTPM (vital, limit 1); midbrain: 9.2 nTPM (vital, limit 1); retina: 8 nTPM (vital, limit 1); choroid plexus: 4.3 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DMRTC1B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000184933,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR6A2,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000185002,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 16.9811% (minimum 70%, Approved); colon: 64.2857% (minimum 70%, Missing); duodenum: 29.0323% (minimum 70%, Approved); pancreas: 29.0323% (minimum 75%, Missing); rectum: 42.8571% (minimum 70%, Missing); small intestine: 42.8571% (minimum 75%, Missing); stomach: 12.5000% (minimum 70%, Missing)",0.35,-0.575,-0.530189,0,2,partial,4.4,6.3,0,"stomach: 6.3 nTPM (protected, limit 3); adrenal gland: 4.4 nTPM (vital, limit 2); duodenum: 2.2 nTPM (vital, limit 2); pancreas: 2.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",colon / glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),53,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RFX6,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000185013,True,compatible,,True,True,True,,0.321831,0.274576,0.230114,0,80,unavailable,0.7,0.9,1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NT5C1B,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000185046,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 13.5397% (minimum 75%, Missing); basal ganglia: 9.3085% (minimum 75%, Missing); cerebellum: 22.7273% (minimum 60%, Enhanced); cerebral cortex: 9.9291% (minimum 60%, Enhanced); choroid plexus: 67.3077% (minimum 75%, Missing); colon: 64.8148% (minimum 70%, Missing); hippocampal formation: 10.4012% (minimum 75%, Missing); hypothalamus: 15.9091% (minimum 75%, Missing); midbrain: 15.4867% (minimum 75%, Missing); pituitary gland: 41.6667% (minimum 75%, Missing); retina: 54.2636% (minimum 75%, Missing); skeletal muscle: 30.7018% (minimum 60%, Enhanced); spinal cord: 10.4167% (minimum 75%, Missing)",0.103448,-0.0518519,-0.656915,0,10,partial,68.2,3.8,4.6,"basal ganglia: 68.2 nTPM (vital, limit 1); cerebral cortex: 63.5 nTPM (vital, limit 6); hippocampal formation: 60.3 nTPM (vital, limit 1); spinal cord: 60.2 nTPM (vital, limit 1); amygdala: 44.7 nTPM (vital, limit 1); midbrain: 38.2 nTPM (vital, limit 1); hypothalamus: 37 nTPM (vital, limit 1); cerebellum: 23.8 nTPM (vital, limit 6); skeletal muscle: 15.8 nTPM (vital, limit 6); pituitary gland: 9.8 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); choroid plexus: 3.4 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ANKS1B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000185055,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 69.8297% (minimum 75%, Missing)",0.313087,0.272881,-0.0517032,0,80,unavailable,12.4,0.8,1.1,"choroid plexus: 12.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EFCAB10,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,False,False,False,False,unchanged,
ENSG00000185056,True,compatible,,True,True,True,,0.35,0.3,0.240566,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C5orf47,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000185104,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.4118% (minimum 75%, Missing); amygdala: 66.2921% (minimum 75%, Missing); basal ganglia: 63.4409% (minimum 75%, Missing); bone marrow: 60.2041% (minimum 75%, Missing); cerebellum: 50.4274% (minimum 75%, Missing); cerebral cortex: 57.8431% (minimum 75%, Missing); choroid plexus: 70.2381% (minimum 75%, Missing); colon: 59.5960% (minimum 70%, Missing); duodenum: 71.0843% (minimum 75%, Missing); esophagus: 60.2041% (minimum 70%, Missing); heart muscle: 47.2000% (minimum 75%, Missing); hippocampal formation: 65.5556% (minimum 75%, Missing); hypothalamus: 63.4409% (minimum 75%, Missing); kidney: 60.2041% (minimum 75%, Missing); liver: 65.5556% (minimum 70%, Approved); lung: 67.8161% (minimum 75%, Missing); lymph node: 67.0455% (minimum 70%, Missing); midbrain: 68.6047% (minimum 75%, Missing); pancreas: 60.2041% (minimum 75%, Missing); parathyroid gland: 50.4274% (minimum 70%, Missing); pituitary gland: 67.8161% (minimum 75%, Missing); rectum: 62.1053% (minimum 70%, Missing); retina: 46.0938% (minimum 75%, Missing); salivary gland: 66.2921% (minimum 70%, Missing); skeletal muscle: 33.3333% (minimum 75%, Missing); skin: 59.5960% (minimum 65%, Missing); small intestine: 68.6047% (minimum 75%, Missing); smooth muscle: 59.5960% (minimum 75%, Missing); spinal cord: 68.6047% (minimum 75%, Missing); thymus: 56.1905% (minimum 65%, Missing); thyroid gland: 56.1905% (minimum 65%, Missing); tongue: 39.5973% (minimum 70%, Missing); urinary bladder: 64.1304% (minimum 70%, Missing)",-0.0880952,-0.304027,-0.416667,0,8,partial,11.8,9,4.6,"skeletal muscle: 11.8 nTPM (vital, limit 1); tongue: 9 nTPM (protected, limit 3); retina: 6.9 nTPM (vital, limit 1); heart muscle: 6.6 nTPM (vital, limit 1); parathyroid gland: 5.8 nTPM (protected, limit 3); cerebellum: 5.8 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); pancreas: 3.9 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 3); bone marrow: 3.9 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); hypothalamus: 3.4 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 2); hippocampal formation: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAF1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000185156,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pancreas: 73.1563% (minimum 75%, Missing)",0.232562,0.0898089,-0.0184366,0,80,unavailable,9.1,6.6,3.3,"pancreas: 9.1 nTPM (vital, limit 1); salivary gland: 6.6 nTPM (protected, limit 3); pituitary gland: 4.7 nTPM (vital, limit 1); parathyroid gland: 4 nTPM (protected, limit 3); stomach: 3.9 nTPM (protected, limit 3); duodenum: 2.3 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MFSD6L,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000185177,True,compatible,,True,True,True,,0.314286,0.3,0.214286,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF479,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000185236,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.7046% (minimum 65%, Missing); adrenal gland: 54.0236% (minimum 75%, Missing); amygdala: 47.0714% (minimum 75%, Missing); basal ganglia: 44.4131% (minimum 75%, Missing); bone marrow: 61.9235% (minimum 75%, Missing); cerebellum: 44.2524% (minimum 75%, Missing); cerebral cortex: 44.2524% (minimum 75%, Missing); choroid plexus: 63.0946% (minimum 75%, Missing); colon: 53.4726% (minimum 70%, Missing); duodenum: 59.7072% (minimum 75%, Missing); esophagus: 54.3435% (minimum 70%, Missing); heart muscle: 40.3740% (minimum 75%, Missing); hippocampal formation: 45.5712% (minimum 75%, Missing); hypothalamus: 47.2938% (minimum 75%, Missing); kidney: 46.6921% (minimum 75%, Missing); liver: 45.7416% (minimum 75%, Missing); lung: 53.6288% (minimum 75%, Missing); lymph node: 65.7706% (minimum 70%, Missing); midbrain: 43.3124% (minimum 75%, Missing); pancreas: 46.6328% (minimum 75%, Missing); parathyroid gland: 69.9936% (minimum 70%, Missing); pituitary gland: 49.4165% (minimum 75%, Missing); retina: 74.8470% (minimum 75%, Missing); salivary gland: 52.1060% (minimum 70%, Missing); skeletal muscle: 48.8248% (minimum 75%, Missing); skin: 52.7552% (minimum 65%, Missing); small intestine: 53.8123% (minimum 75%, Missing); spinal cord: 40.1972% (minimum 75%, Missing); spleen: 48.7384% (minimum 65%, Missing); stomach: 48.9987% (minimum 70%, Missing); thyroid gland: 35.0972% (minimum 65%, Missing); urinary bladder: 53.3689% (minimum 70%, Missing)",-0.299028,-0.210013,-0.348028,0,80,unavailable,163.8,114.6,203.6,"thyroid gland: 203.6 nTPM (manageable, limit 5); spinal cord: 163.8 nTPM (vital, limit 1); heart muscle: 162.6 nTPM (vital, limit 1); midbrain: 144.1 nTPM (vital, limit 1); cerebellum: 138.7 nTPM (vital, limit 1); cerebral cortex: 138.7 nTPM (vital, limit 1); basal ganglia: 137.8 nTPM (vital, limit 1); hippocampal formation: 131.5 nTPM (vital, limit 1); liver: 130.6 nTPM (vital, limit 1); pancreas: 126 nTPM (vital, limit 1); kidney: 125.7 nTPM (vital, limit 1); amygdala: 123.8 nTPM (vital, limit 1); hypothalamus: 122.7 nTPM (vital, limit 1); spleen: 115.8 nTPM (manageable, limit 5); skeletal muscle: 115.4 nTPM (vital, limit 1); stomach: 114.6 nTPM (protected, limit 3); pituitary gland: 112.7 nTPM (vital, limit 1); salivary gland: 101.2 nTPM (protected, limit 3); adipose tissue: 98.8 nTPM (manageable, limit 5); skin: 98.6 nTPM (manageable, limit 5); urinary bladder: 96.2 nTPM (protected, limit 3); colon: 95.8 nTPM (protected, limit 3); lung: 95.2 nTPM (vital, limit 1); small intestine: 94.5 nTPM (vital, limit 1); adrenal gland: 93.7 nTPM (vital, limit 1); esophagus: 92.5 nTPM (protected, limit 3); duodenum: 74.3 nTPM (vital, limit 1); bone marrow: 67.7 nTPM (vital, limit 1); choroid plexus: 64.4 nTPM (vital, limit 1); lymph node: 57.3 nTPM (protected, limit 3); parathyroid gland: 47.2 nTPM (protected, limit 3); thymus: 42.9 nTPM (manageable, limit 5); retina: 37 nTPM (vital, limit 1); tongue: 35.4 nTPM (protected, limit 3); smooth muscle: 26.8 nTPM (vital, limit 1); rectum: 22.6 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RAB11B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000185245,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 42.8571% (minimum 55%, Supported); amygdala: 75.0000% (minimum 75%, Missing); basal ganglia: 60.0000% (minimum 75%, Missing); bone marrow: 5.7692% (minimum 75%, Missing); cerebellum: 50.0000% (minimum 65%, Supported); cerebral cortex: 37.5000% (minimum 65%, Supported); colon: 42.8571% (minimum 60%, Supported); duodenum: 20.0000% (minimum 65%, Supported); esophagus: 50.0000% (minimum 60%, Supported); heart muscle: 37.5000% (minimum 65%, Supported); hippocampal formation: 75.0000% (minimum 75%, Missing); kidney: 42.8571% (minimum 65%, Supported); liver: 42.8571% (minimum 65%, Supported); lung: 20.0000% (minimum 65%, Supported); lymph node: 2.0548% (minimum 60%, Supported); rectum: 42.8571% (minimum 60%, Supported); retina: 11.5385% (minimum 75%, Missing); salivary gland: 25.0000% (minimum 60%, Supported); skeletal muscle: 10.3448% (minimum 65%, Supported); skin: 11.5385% (minimum 55%, Supported); small intestine: 20.0000% (minimum 65%, Supported); spleen: 7.6923% (minimum 65%, Missing); stomach: 30.0000% (minimum 60%, Supported); thymus: 33.3333% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 55%, Supported)",-0.573077,-0.579452,-0.692308,0,0,routine_complete,4.9,14.3,3.6,"lymph node: 14.3 nTPM (protected, limit 6); bone marrow: 4.9 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Supported); spleen / cells in red pulp: Medium (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GP1BA,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000185247,True,compatible,,True,True,True,,0.35,0.295146,0.245146,0,80,unavailable,0.1,0.1,0,,,0,not_established,not_triggered,,,False,MAGE-A family target with trace non-reproductive HPA RNA; keep clinical discoverability but do not silently promote into the default strict CTA set.,True,Apply the same policy transition to the historical trace-RNA holdback. The current numerical gates assess the 0.1 nTPM choroid-plexus signal; no gene-specific ceiling or positive-IHC exemption.,True,Research-screen eligibility does not establish clinical safety. Frozen core/extended policies retain their original holdback.,https://pirl-unc.github.io/oncoref/normal-tissue-scopes/,MAGEA11,current_adaptive,True,True,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,True,True,gained,current_adaptive
ENSG00000185261,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 72.9730% (minimum 75%, Missing); basal ganglia: 61.3636% (minimum 75%, Missing); bone marrow: 71.0526% (minimum 75%, Uncertain); cerebellum: 62.7907% (minimum 75%, Missing); cerebral cortex: 62.7907% (minimum 75%, Missing); kidney: 67.5000% (minimum 75%, Missing); liver: 72.9730% (minimum 75%, Missing); parathyroid gland: 67.5000% (minimum 70%, Missing); pituitary gland: 72.9730% (minimum 75%, Missing); retina: 45.7627% (minimum 75%, Missing); skeletal muscle: 65.8537% (minimum 75%, Missing); thyroid gland: 61.3636% (minimum 65%, Missing)",-0.0363636,-0.025,-0.292373,0,3,partial,3.2,1.3,1.7,"retina: 3.2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KIAA0825,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000185264,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CIMIP4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000185269,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.334222,0.284962,0.181059,0,80,unavailable,9.7,2,2.1,"liver: 9.7 nTPM (vital, limit 1); skeletal muscle: 7.9 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NOTUM,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000185278,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 61.4815% (minimum 75%, Missing); retina: 44.8649% (minimum 75%, Missing)",0.0533898,0.00940171,-0.301351,0,1,partial,10.2,3.4,3.5,"retina: 10.2 nTPM (vital, limit 1); bone marrow: 5.2 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); midbrain: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZBTB37,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000185290,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308333,0.278723,0.201199,0,80,unavailable,17.7,7.5,15,"kidney: 17.7 nTPM (vital, limit 1); thyroid gland: 15 nTPM (manageable, limit 5); pituitary gland: 12.4 nTPM (vital, limit 1); salivary gland: 7.5 nTPM (protected, limit 3); amygdala: 7 nTPM (vital, limit 1); basal ganglia: 6.3 nTPM (vital, limit 1); cerebellum: 6.2 nTPM (vital, limit 1); stomach: 5.8 nTPM (protected, limit 3); cerebral cortex: 5 nTPM (vital, limit 1); hypothalamus: 4.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); parathyroid gland: 3.2 nTPM (protected, limit 3); midbrain: 2.7 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NUPR2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000185294,True,compatible,,True,True,True,,0.35,0.3,0.23895,0,5,partial,1.7,0,0,,,49,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPPL2C,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,False,gained,selectivity_revised
ENSG00000185306,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.152198,0.3,0.00257732,0,2,partial,2.4,0.9,1.8,"choroid plexus: 2.4 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C12orf56,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000185313,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"heart muscle: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SCN10A,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000185352,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.6061% (minimum 65%, Missing); adrenal gland: 32.7869% (minimum 75%, Missing); amygdala: 27.7778% (minimum 75%, Missing); basal ganglia: 25.3165% (minimum 75%, Missing); cerebellum: 57.1429% (minimum 75%, Missing); cerebral cortex: 10.6952% (minimum 75%, Missing); heart muscle: 68.9655% (minimum 75%, Missing); hippocampal formation: 15.5039% (minimum 75%, Missing); hypothalamus: 22.9885% (minimum 75%, Missing); kidney: 71.4286% (minimum 75%, Missing); midbrain: 40.0000% (minimum 75%, Missing); pancreas: 48.7805% (minimum 75%, Missing); parathyroid gland: 50.0000% (minimum 70%, Missing); pituitary gland: 51.2821% (minimum 75%, Missing); retina: 47.6190% (minimum 75%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing); smooth muscle: 57.1429% (minimum 75%, Missing); spinal cord: 57.1429% (minimum 75%, Missing); thyroid gland: 46.5116% (minimum 65%, Missing); urinary bladder: 43.4783% (minimum 70%, Missing)",-0.184884,-0.265217,-0.643048,0,80,unavailable,16.7,2.6,2.3,"cerebral cortex: 16.7 nTPM (vital, limit 1); hippocampal formation: 10.9 nTPM (vital, limit 1); hypothalamus: 6.7 nTPM (vital, limit 1); basal ganglia: 5.9 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); adrenal gland: 4.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HS6ST3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000185414,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 50.5155% (minimum 60%, Approved); adrenal gland: 44.7489% (minimum 70%, Approved); amygdala: 47.5728% (minimum 75%, Missing); basal ganglia: 51.3089% (minimum 75%, Missing); bone marrow: 74.8092% (minimum 75%, Missing); cerebellum: 49.7462% (minimum 75%, Missing); cerebral cortex: 44.3439% (minimum 75%, Missing); choroid plexus: 74.2424% (minimum 75%, Missing); colon: 50.7772% (minimum 65%, Approved); duodenum: 59.0361% (minimum 75%, Missing); esophagus: 40.8333% (minimum 70%, Missing); heart muscle: 37.6923% (minimum 70%, Approved); hippocampal formation: 50.5155% (minimum 75%, Missing); hypothalamus: 46.4455% (minimum 75%, Missing); kidney: 44.7489% (minimum 75%, Missing); liver: 42.4242% (minimum 75%, Missing); lung: 62.8205% (minimum 75%, Missing); lymph node: 65.7718% (minimum 70%, Missing); midbrain: 48.2759% (minimum 75%, Missing); pancreas: 47.3430% (minimum 75%, Missing); parathyroid gland: 57.9882% (minimum 70%, Missing); pituitary gland: 58.3333% (minimum 75%, Missing); rectum: 60.1227% (minimum 70%, Missing); retina: 62.8205% (minimum 75%, Missing); salivary gland: 50.5155% (minimum 70%, Missing); skeletal muscle: 25.5875% (minimum 70%, Approved); skin: 48.7562% (minimum 65%, Missing); small intestine: 55.6818% (minimum 75%, Missing); smooth muscle: 65.7718% (minimum 70%, Approved); spinal cord: 44.7489% (minimum 75%, Missing); spleen: 58.6826% (minimum 65%, Missing); stomach: 50.0000% (minimum 70%, Missing); thymus: 57.6471% (minimum 65%, Missing); thyroid gland: 59.0361% (minimum 65%, Missing); tongue: 32.6667% (minimum 70%, Missing); urinary bladder: 52.1277% (minimum 70%, Missing)",-0.162438,-0.373333,-0.444125,0,7,partial,28.5,20.2,10.3,"skeletal muscle: 28.5 nTPM (vital, limit 2); tongue: 20.2 nTPM (protected, limit 3); heart muscle: 16.2 nTPM (vital, limit 2); esophagus: 14.2 nTPM (protected, limit 3); liver: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.3 nTPM (vital, limit 1); adrenal gland: 12.1 nTPM (vital, limit 2); spinal cord: 12.1 nTPM (vital, limit 1); kidney: 12.1 nTPM (vital, limit 1); hypothalamus: 11.3 nTPM (vital, limit 1); pancreas: 10.9 nTPM (vital, limit 1); amygdala: 10.8 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); cerebellum: 9.9 nTPM (vital, limit 1); stomach: 9.8 nTPM (protected, limit 3); salivary gland: 9.6 nTPM (protected, limit 3); hippocampal formation: 9.6 nTPM (vital, limit 1); colon: 9.5 nTPM (protected, limit 4); basal ganglia: 9.3 nTPM (vital, limit 1); urinary bladder: 9 nTPM (protected, limit 3); small intestine: 7.8 nTPM (vital, limit 1); thymus: 7.2 nTPM (manageable, limit 5); parathyroid gland: 7.1 nTPM (protected, limit 3); pituitary gland: 7 nTPM (vital, limit 1); spleen: 6.9 nTPM (manageable, limit 5); duodenum: 6.8 nTPM (vital, limit 1); thyroid gland: 6.8 nTPM (manageable, limit 5); rectum: 6.5 nTPM (protected, limit 3); retina: 5.8 nTPM (vital, limit 1); lung: 5.8 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); smooth muscle: 5.1 nTPM (vital, limit 2); choroid plexus: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells type II: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MRPL30,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000185448,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM47A,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000185480,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 29.2308% (minimum 75%, Missing); colon: 56.7164% (minimum 70%, Missing); duodenum: 63.3333% (minimum 70%, Approved); esophagus: 52.0548% (minimum 70%, Missing); lymph node: 48.1013% (minimum 65%, Approved); rectum: 50.6667% (minimum 70%, Missing); small intestine: 58.4615% (minimum 75%, Missing); smooth muscle: 70.3704% (minimum 75%, Missing); stomach: 67.8571% (minimum 70%, Missing); thymus: 33.9286% (minimum 65%, Missing); urinary bladder: 67.8571% (minimum 70%, Missing)",-0.310714,-0.193333,-0.457692,0,8,partial,9.2,4.1,7.4,"bone marrow: 9.2 nTPM (vital, limit 1); thymus: 7.4 nTPM (manageable, limit 5); lymph node: 4.1 nTPM (protected, limit 4); rectum: 3.7 nTPM (protected, limit 3); esophagus: 3.5 nTPM (protected, limit 3); small intestine: 2.7 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 2); smooth muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),48,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PARPBP,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000185523,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308333,0.234959,0.0486111,0,80,unavailable,2.9,0.8,0.5,"pancreas: 2.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA45,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000185634,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 54.5455% (minimum 75%, Missing); basal ganglia: 50.0000% (minimum 75%, Missing); cerebral cortex: 57.6271% (minimum 75%, Missing); hippocampal formation: 48.5714% (minimum 75%, Missing); hypothalamus: 62.5767% (minimum 75%, Missing); midbrain: 44.9339% (minimum 75%, Missing); spinal cord: 39.8437% (minimum 75%, Missing)",0.294444,0.0906977,-0.351563,0,80,unavailable,15.4,2.7,0.6,"spinal cord: 15.4 nTPM (vital, limit 1); midbrain: 12.5 nTPM (vital, limit 1); hippocampal formation: 10.8 nTPM (vital, limit 1); basal ganglia: 10.2 nTPM (vital, limit 1); amygdala: 8.5 nTPM (vital, limit 1); cerebral cortex: 7.5 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SHC4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000185658,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.7841% (minimum 65%, Missing); adrenal gland: 54.7030% (minimum 75%, Missing); amygdala: 35.4167% (minimum 75%, Missing); basal ganglia: 33.6890% (minimum 75%, Missing); bone marrow: 54.5679% (minimum 75%, Missing); cerebellum: 54.1667% (minimum 75%, Missing); cerebral cortex: 29.5060% (minimum 75%, Missing); choroid plexus: 62.4294% (minimum 75%, Missing); colon: 64.6199% (minimum 70%, Missing); duodenum: 69.9367% (minimum 75%, Missing); esophagus: 65.5786% (minimum 70%, Missing); heart muscle: 59.5687% (minimum 75%, Missing); hippocampal formation: 38.5017% (minimum 75%, Missing); hypothalamus: 35.4735% (minimum 75%, Missing); kidney: 59.2493% (minimum 75%, Missing); liver: 46.9214% (minimum 75%, Missing); lung: 63.3238% (minimum 75%, Missing); lymph node: 58.9333% (minimum 70%, Missing); midbrain: 42.5819% (minimum 75%, Missing); pancreas: 53.3816% (minimum 75%, Missing); parathyroid gland: 63.6888% (minimum 70%, Missing); pituitary gland: 63.1429% (minimum 75%, Missing); rectum: 65.0000% (minimum 70%, Missing); retina: 37.1429% (minimum 75%, Missing); salivary gland: 66.1677% (minimum 70%, Missing); skeletal muscle: 51.1574% (minimum 75%, Missing); skin: 60.8815% (minimum 65%, Missing); small intestine: 66.7674% (minimum 75%, Missing); smooth muscle: 67.3780% (minimum 75%, Missing); spinal cord: 51.0393% (minimum 75%, Missing); stomach: 65.1917% (minimum 70%, Missing); thymus: 60.3825% (minimum 65%, Missing); thyroid gland: 53.6408% (minimum 65%, Missing); tongue: 48.8938% (minimum 70%, Missing); urinary bladder: 64.8094% (minimum 70%, Missing)",-0.113592,-0.211062,-0.45494,0,1,partial,52.8,23.1,19.1,"cerebral cortex: 52.8 nTPM (vital, limit 1); basal ganglia: 43.5 nTPM (vital, limit 1); amygdala: 40.3 nTPM (vital, limit 1); hypothalamus: 40.2 nTPM (vital, limit 1); retina: 37.4 nTPM (vital, limit 1); hippocampal formation: 35.3 nTPM (vital, limit 1); midbrain: 29.8 nTPM (vital, limit 1); liver: 25 nTPM (vital, limit 1); tongue: 23.1 nTPM (protected, limit 3); spinal cord: 21.2 nTPM (vital, limit 1); skeletal muscle: 21.1 nTPM (vital, limit 1); pancreas: 19.3 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); cerebellum: 18.7 nTPM (vital, limit 1); bone marrow: 18.4 nTPM (vital, limit 1); adrenal gland: 18.3 nTPM (vital, limit 1); lymph node: 15.4 nTPM (protected, limit 3); kidney: 15.2 nTPM (vital, limit 1); heart muscle: 15 nTPM (vital, limit 1); thymus: 14.5 nTPM (manageable, limit 5); skin: 14.2 nTPM (manageable, limit 5); choroid plexus: 13.3 nTPM (vital, limit 1); adipose tissue: 13.1 nTPM (manageable, limit 5); pituitary gland: 12.9 nTPM (vital, limit 1); lung: 12.8 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 3); colon: 12.1 nTPM (protected, limit 3); urinary bladder: 12 nTPM (protected, limit 3); rectum: 11.9 nTPM (protected, limit 3); stomach: 11.8 nTPM (protected, limit 3); esophagus: 11.6 nTPM (protected, limit 3); salivary gland: 11.3 nTPM (protected, limit 3); small intestine: 11 nTPM (vital, limit 1); smooth muscle: 10.7 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); duodenum: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BRWD1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000185662,True,compatible,,True,True,True,,0.345902,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SMIM23,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000185666,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 64.9123% (minimum 75%, Missing); basal ganglia: 63.7931% (minimum 75%, Missing); bone marrow: 62.7119% (minimum 75%, Uncertain); cerebellum: 74.0000% (minimum 75%, Missing); cerebral cortex: 42.0455% (minimum 75%, Missing); hippocampal formation: 67.2727% (minimum 75%, Missing); hypothalamus: 66.0714% (minimum 75%, Missing); pituitary gland: 69.8113% (minimum 75%, Missing); retina: 51.3889% (minimum 75%, Missing); spinal cord: 72.5490% (minimum 75%, Missing)",0.09,0.04,-0.329545,0,2,partial,5.1,1.3,1.3,"cerebral cortex: 5.1 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SYN3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000185670,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 73.6842% (minimum 75%, Missing); bone marrow: 64.6154% (minimum 75%, Missing); cerebellum: 73.6842% (minimum 75%, Missing); cerebral cortex: 63.6364% (minimum 75%, Missing); colon: 64.6154% (minimum 70%, Missing); duodenum: 65.6250% (minimum 75%, Missing); heart muscle: 59.1549% (minimum 75%, Missing); kidney: 71.1864% (minimum 75%, Missing); lung: 60.0000% (minimum 75%, Missing); lymph node: 64.6154% (minimum 70%, Missing); pancreas: 63.6364% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing); rectum: 67.7419% (minimum 70%, Missing); retina: 58.3333% (minimum 75%, Missing); salivary gland: 56.0000% (minimum 70%, Missing); skeletal muscle: 60.8696% (minimum 75%, Missing); skin: 42.8571% (minimum 65%, Missing); small intestine: 65.6250% (minimum 75%, Missing); smooth muscle: 71.1864% (minimum 75%, Missing); spinal cord: 72.4138% (minimum 75%, Missing); stomach: 46.6667% (minimum 70%, Missing); thymus: 60.8696% (minimum 65%, Missing); thyroid gland: 61.7647% (minimum 65%, Missing); tongue: 57.5342% (minimum 70%, Missing)",-0.221429,-0.233333,-0.166667,0,1,partial,3,4.8,5.6,"skin: 5.6 nTPM (manageable, limit 5); stomach: 4.8 nTPM (protected, limit 3); salivary gland: 3.3 nTPM (protected, limit 3); tongue: 3.1 nTPM (protected, limit 3); retina: 3 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZBTB3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000185686,True,compatible,,True,True,True,,0.348047,0.3,0.243197,0,3,partial,3.6,0.2,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRAME,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,False,unchanged,
ENSG00000185697,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lymph node: 36.6559% (minimum 70%, Uncertain); retina: 66.6667% (minimum 75%, Missing); spleen: 60.6383% (minimum 65%, Uncertain)",-0.043617,-0.333441,-0.0833333,0,3,partial,5.7,19.7,7.4,"lymph node: 19.7 nTPM (protected, limit 3); spleen: 7.4 nTPM (manageable, limit 5); retina: 5.7 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 2.9 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MYBL1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000185730,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.0864% (minimum 65%, Missing); adrenal gland: 57.3333% (minimum 75%, Missing); amygdala: 51.8072% (minimum 75%, Missing); basal ganglia: 51.8072% (minimum 75%, Missing); bone marrow: 55.1282% (minimum 75%, Missing); cerebellum: 44.3299% (minimum 75%, Missing); cerebral cortex: 42.5743% (minimum 75%, Missing); choroid plexus: 72.8814% (minimum 75%, Missing); colon: 57.3333% (minimum 70%, Missing); duodenum: 42.1569% (minimum 75%, Missing); esophagus: 63.2353% (minimum 70%, Missing); heart muscle: 60.5634% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 46.2366% (minimum 75%, Missing); kidney: 57.3333% (minimum 75%, Missing); liver: 48.8636% (minimum 75%, Missing); lung: 61.4286% (minimum 75%, Missing); lymph node: 53.7500% (minimum 70%, Missing); midbrain: 53.0864% (minimum 75%, Missing); pancreas: 46.7391% (minimum 75%, Missing); parathyroid gland: 50.5882% (minimum 70%, Missing); pituitary gland: 58.1081% (minimum 75%, Missing); rectum: 69.3548% (minimum 70%, Missing); retina: 55.1282% (minimum 75%, Missing); salivary gland: 43.8776% (minimum 70%, Missing); skeletal muscle: 53.7500% (minimum 75%, Missing); skin: 40.5660% (minimum 65%, Missing); small intestine: 54.4304% (minimum 75%, Missing); smooth muscle: 66.1538% (minimum 75%, Missing); spinal cord: 54.4304% (minimum 75%, Missing); spleen: 52.4390% (minimum 65%, Missing); stomach: 57.3333% (minimum 70%, Missing); thyroid gland: 54.4304% (minimum 65%, Missing); tongue: 65.1515% (minimum 70%, Missing); urinary bladder: 54.4304% (minimum 70%, Missing)",-0.24434,-0.261224,-0.328431,0,80,unavailable,5.9,5.5,6.3,"skin: 6.3 nTPM (manageable, limit 5); duodenum: 5.9 nTPM (vital, limit 1); cerebral cortex: 5.8 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); cerebellum: 5.4 nTPM (vital, limit 1); hypothalamus: 5 nTPM (vital, limit 1); pancreas: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 3); basal ganglia: 4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); midbrain: 3.8 nTPM (vital, limit 1); lymph node: 3.7 nTPM (protected, limit 3); skeletal muscle: 3.7 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 3); small intestine: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); bone marrow: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); stomach: 3.2 nTPM (protected, limit 3); adrenal gland: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); pituitary gland: 3.1 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF696,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000185775,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA31A6,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000185792,False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.35,0.3,0.202381,0,2,unreliable,0.1,0,0,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin 1 / Langerhans; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NLRP9,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000185798,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.209356,0.156295,0.11244,0,5,partial,14.5,12.1,11.8,"bone marrow: 14.5 nTPM (vital, limit 2); skeletal muscle: 12.6 nTPM (vital, limit 2); tongue: 12.1 nTPM (protected, limit 3); thymus: 11.8 nTPM (manageable, limit 5); skin: 11.6 nTPM (manageable, limit 10); choroid plexus: 11.5 nTPM (vital, limit 1); spleen: 10.6 nTPM (manageable, limit 10); lymph node: 10.3 nTPM (protected, limit 4); liver: 9.7 nTPM (vital, limit 2); parathyroid gland: 9.6 nTPM (protected, limit 3); esophagus: 8.7 nTPM (protected, limit 4); kidney: 8.6 nTPM (vital, limit 1); retina: 8.6 nTPM (vital, limit 1); heart muscle: 7.8 nTPM (vital, limit 2); colon: 7.8 nTPM (protected, limit 3); small intestine: 7.7 nTPM (vital, limit 1); smooth muscle: 7.1 nTPM (vital, limit 2); adrenal gland: 7.1 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 3); urinary bladder: 7 nTPM (protected, limit 3); cerebellum: 7 nTPM (vital, limit 2); rectum: 6.9 nTPM (protected, limit 3); thyroid gland: 6.9 nTPM (manageable, limit 5); salivary gland: 6.8 nTPM (protected, limit 3); basal ganglia: 6.8 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 2); spinal cord: 6.7 nTPM (vital, limit 1); pituitary gland: 6.5 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); midbrain: 6.4 nTPM (vital, limit 1); hypothalamus: 6.3 nTPM (vital, limit 1); amygdala: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); pancreas: 5.7 nTPM (vital, limit 1); duodenum: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (ciliary rootlets): Medium (Approved); bronchus / ciliated cells (tip of cilia): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,WDR53,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000185823,True,compatible,,True,True,True,,0.198485,0.265517,0.0277778,0,80,unavailable,0.8,0.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder; lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NPAP1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000185829,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 68.4211% (minimum 75%, Uncertain); cerebellum: 73.4463% (minimum 75%, Missing); choroid plexus: 63.6215% (minimum 75%, Missing); liver: 73.3083% (minimum 75%, Missing); lung: 74.8560% (minimum 75%, Missing); parathyroid gland: 64.4628% (minimum 70%, Missing); rectum: 68.3012% (minimum 70%, Missing); retina: 53.7190% (minimum 75%, Missing); skeletal muscle: 69.2718% (minimum 75%, Uncertain); smooth muscle: 67.3575% (minimum 75%, Missing); tongue: 66.3265% (minimum 70%, Missing)",0.0166667,-0.0553719,-0.21281,0,6,partial,33.6,21.5,19.5,"retina: 33.6 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); parathyroid gland: 21.5 nTPM (protected, limit 3); tongue: 19.8 nTPM (protected, limit 3); thymus: 19.5 nTPM (manageable, limit 5); smooth muscle: 18.9 nTPM (vital, limit 1); rectum: 18.1 nTPM (protected, limit 3); thyroid gland: 18 nTPM (manageable, limit 5); bone marrow: 18 nTPM (vital, limit 1); skin: 17.6 nTPM (manageable, limit 5); skeletal muscle: 17.3 nTPM (vital, limit 1); lymph node: 16.1 nTPM (protected, limit 3); spleen: 14.4 nTPM (manageable, limit 5); liver: 14.2 nTPM (vital, limit 1); cerebellum: 14.1 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (manageable, limit 5); lung: 13.1 nTPM (vital, limit 1); pituitary gland: 13 nTPM (vital, limit 1); kidney: 12.8 nTPM (vital, limit 1); colon: 12.5 nTPM (protected, limit 3); adrenal gland: 11.5 nTPM (vital, limit 1); salivary gland: 11 nTPM (protected, limit 3); heart muscle: 10.5 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 3); stomach: 10.3 nTPM (protected, limit 3); esophagus: 9.8 nTPM (protected, limit 3); cerebral cortex: 9.5 nTPM (vital, limit 1); pancreas: 9.2 nTPM (vital, limit 1); small intestine: 9.2 nTPM (vital, limit 1); duodenum: 7.3 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); basal ganglia: 6 nTPM (vital, limit 1); hypothalamus: 5.9 nTPM (vital, limit 1); amygdala: 5.3 nTPM (vital, limit 1); midbrain: 4.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: High (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ARL17A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000185842,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.186576,0.195833,0.0206093,0,3,partial,6.4,2.5,4.2,"pituitary gland: 6.4 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hypothalamus: 4 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); colon / endothelial cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAH14,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000185863,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.2,1.4,0,,,55,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TMEM210,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000185883,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.5282% (minimum 65%, Missing); adrenal gland: 45.6176% (minimum 75%, Missing); amygdala: 35.4634% (minimum 75%, Missing); basal ganglia: 34.0508% (minimum 75%, Missing); bone marrow: 52.7020% (minimum 75%, Missing); cerebellum: 30.4302% (minimum 75%, Missing); cerebral cortex: 25.4079% (minimum 75%, Missing); choroid plexus: 47.6857% (minimum 75%, Missing); colon: 54.6072% (minimum 70%, Missing); duodenum: 68.5432% (minimum 75%, Missing); esophagus: 38.0204% (minimum 70%, Missing); heart muscle: 49.5193% (minimum 75%, Missing); hippocampal formation: 34.1550% (minimum 75%, Missing); hypothalamus: 32.9398% (minimum 75%, Missing); kidney: 33.2726% (minimum 75%, Missing); liver: 49.8759% (minimum 75%, Missing); lung: 47.3374% (minimum 75%, Missing); midbrain: 38.4424% (minimum 75%, Missing); pancreas: 59.5612% (minimum 75%, Missing); parathyroid gland: 66.7220% (minimum 70%, Missing); pituitary gland: 38.6792% (minimum 75%, Missing); retina: 65.2273% (minimum 75%, Missing); salivary gland: 49.1559% (minimum 70%, Missing); skeletal muscle: 40.8915% (minimum 75%, Missing); skin: 42.4377% (minimum 65%, Missing); small intestine: 55.6973% (minimum 75%, Missing); spinal cord: 42.6720% (minimum 75%, Missing); spleen: 48.1198% (minimum 65%, Missing); stomach: 54.0926% (minimum 70%, Missing); thyroid gland: 55.4054% (minimum 65%, Missing); urinary bladder: 60.7132% (minimum 70%, Missing)",-0.225623,-0.319796,-0.495921,0,80,unavailable,589.8,327.5,272.5,"cerebral cortex: 589.8 nTPM (vital, limit 1); cerebellum: 459.3 nTPM (vital, limit 1); hypothalamus: 409 nTPM (vital, limit 1); kidney: 402.9 nTPM (vital, limit 1); basal ganglia: 389.1 nTPM (vital, limit 1); hippocampal formation: 387.3 nTPM (vital, limit 1); amygdala: 365.6 nTPM (vital, limit 1); esophagus: 327.5 nTPM (protected, limit 3); midbrain: 321.7 nTPM (vital, limit 1); pituitary gland: 318.5 nTPM (vital, limit 1); skeletal muscle: 290.4 nTPM (vital, limit 1); skin: 272.5 nTPM (manageable, limit 5); spinal cord: 269.9 nTPM (vital, limit 1); adrenal gland: 239.5 nTPM (vital, limit 1); lung: 223.5 nTPM (vital, limit 1); choroid plexus: 220.4 nTPM (vital, limit 1); spleen: 216.6 nTPM (manageable, limit 5); salivary gland: 207.8 nTPM (protected, limit 3); heart muscle: 204.8 nTPM (vital, limit 1); liver: 201.9 nTPM (vital, limit 1); adipose tissue: 196.7 nTPM (manageable, limit 5); bone marrow: 180.3 nTPM (vital, limit 1); stomach: 170.5 nTPM (protected, limit 3); colon: 167 nTPM (protected, limit 3); thyroid gland: 161.7 nTPM (manageable, limit 5); small intestine: 159.8 nTPM (vital, limit 1); pancreas: 136.4 nTPM (vital, limit 1); urinary bladder: 130 nTPM (protected, limit 3); retina: 107.1 nTPM (vital, limit 1); parathyroid gland: 100.2 nTPM (protected, limit 3); duodenum: 92.2 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 3); lymph node: 49.6 nTPM (protected, limit 3); thymus: 43.7 nTPM (manageable, limit 5); smooth muscle: 28.8 nTPM (vital, limit 1); rectum: 28.7 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ATP6V0C,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000185888,True,compatible,,True,True,True,,0.35,0.3,0.22619,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRSS38,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000185894,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.0961538,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,BPY2C,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000185920,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"rectum: 68.9320% (minimum 70%, Missing); small intestine: 71.1423% (minimum 75%, Missing); stomach: 68.6654% (minimum 70%, Missing)",0.197255,-0.0133462,-0.0385772,0,3,partial,14.4,16.2,6.4,"stomach: 16.2 nTPM (protected, limit 3); rectum: 16 nTPM (protected, limit 3); colon: 14.9 nTPM (protected, limit 3); small intestine: 14.4 nTPM (vital, limit 1); duodenum: 9.3 nTPM (vital, limit 1); salivary gland: 8.4 nTPM (protected, limit 3); retina: 8.1 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); cerebral cortex: 7.4 nTPM (vital, limit 1); lung: 7.1 nTPM (vital, limit 1); thyroid gland: 6.4 nTPM (manageable, limit 5); tongue: 6.2 nTPM (protected, limit 3); urinary bladder: 6.2 nTPM (protected, limit 3); cerebellum: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); esophagus: 3.9 nTPM (protected, limit 3); adrenal gland: 3.9 nTPM (vital, limit 1); parathyroid gland: 3.3 nTPM (protected, limit 3); smooth muscle: 2.8 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.7 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: High (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: High (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: High (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PTCH1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000185955,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.338113,0.292537,0.12963,0,2,partial,9.1,1.5,2.5,"midbrain: 9.1 nTPM (vital, limit 1); spinal cord: 8.8 nTPM (vital, limit 1); hippocampal formation: 8.1 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1); amygdala: 7.3 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPACDR,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000185958,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.328723,0.285714,0.176174,0,80,unavailable,1.1,0.2,0.3,"skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM186A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000185972,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344521,0.294521,0.225806,0,80,unavailable,1.8,0.4,0.4,"smooth muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix; gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCIN,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000185982,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,DEFB128,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000186007,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340758,0.267509,0.187063,0,80,unavailable,3.6,1.8,0.5,"cerebellum: 3.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LEMD1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000186026,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 53.8462% (minimum 65%, Missing); adrenal gland: 46.6667% (minimum 75%, Missing); amygdala: 63.6364% (minimum 75%, Missing); basal ganglia: 58.3333% (minimum 75%, Missing); bone marrow: 66.6667% (minimum 75%, Missing); cerebellum: 41.1765% (minimum 75%, Missing); cerebral cortex: 58.3333% (minimum 75%, Missing); choroid plexus: 56.0000% (minimum 75%, Missing); colon: 53.8462% (minimum 70%, Missing); duodenum: 53.8462% (minimum 75%, Missing); esophagus: 60.8696% (minimum 70%, Missing); heart muscle: 51.8519% (minimum 75%, Missing); hippocampal formation: 58.3333% (minimum 75%, Missing); hypothalamus: 58.3333% (minimum 75%, Missing); kidney: 53.8462% (minimum 75%, Missing); liver: 58.3333% (minimum 75%, Missing); lung: 56.0000% (minimum 75%, Missing); lymph node: 46.6667% (minimum 70%, Missing); midbrain: 58.3333% (minimum 75%, Missing); pancreas: 56.0000% (minimum 75%, Missing); parathyroid gland: 58.3333% (minimum 70%, Missing); pituitary gland: 48.2759% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 38.8889% (minimum 75%, Missing); salivary gland: 51.8519% (minimum 70%, Missing); skeletal muscle: 46.6667% (minimum 75%, Missing); skin: 33.3333% (minimum 65%, Missing); small intestine: 50.0000% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 58.3333% (minimum 75%, Missing); spleen: 40.0000% (minimum 65%, Missing); stomach: 56.0000% (minimum 70%, Missing); thymus: 46.6667% (minimum 65%, Missing); thyroid gland: 48.2759% (minimum 65%, Missing); urinary bladder: 56.0000% (minimum 70%, Missing)",-0.316667,-0.233333,-0.361111,0,80,unavailable,2.2,1.6,2.8,"retina: 2.2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); small intestine: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF284,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000186075,True,compatible,,True,True,True,,0.34892,0.29892,0.244624,0,1,partial,0.5,0.7,0.2,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZPBP2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000186086,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 49.0566% (minimum 75%, Missing)",0.35,0.196552,-0.259434,0,80,unavailable,2.7,0.3,0,"liver: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review,tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NBPF6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000186103,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 75.0000% (minimum 75%, Missing); bone marrow: 23.0769% (minimum 75%, Missing); cerebral cortex: 60.0000% (minimum 75%, Missing); duodenum: 60.0000% (minimum 75%, Missing); esophagus: 60.0000% (minimum 70%, Missing); heart muscle: 75.0000% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); liver: 75.0000% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); pancreas: 50.0000% (minimum 75%, Missing); retina: 37.5000% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing); skeletal muscle: 42.8571% (minimum 75%, Missing); skin: 30.0000% (minimum 65%, Missing); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 75.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 42.8571% (minimum 70%, Missing); thyroid gland: 60.0000% (minimum 65%, Missing)",-0.35,-0.271429,-0.519231,0,80,unavailable,1,0.4,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ARGFX,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000186118,True,compatible,,True,True,True,,0.349207,0.298414,0.247887,0,80,unavailable,0.8,0.6,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX38,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000186143,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRR30,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000186150,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293184,0.219582,0,1,partial,3.2,0.7,0.3,"choroid plexus: 3.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,53,not_established,required,local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,UBL4B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000186190,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 44.4444% (minimum 75%, Missing); salivary gland: 44.4444% (minimum 70%, Missing)",0.15,-0.255556,-0.305556,0,80,unavailable,0.5,0.5,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BPIFB3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000186230,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.1724% (minimum 65%, Missing); adrenal gland: 57.1429% (minimum 75%, Missing); amygdala: 66.6667% (minimum 75%, Missing); basal ganglia: 61.5385% (minimum 75%, Missing); bone marrow: 53.3333% (minimum 75%, Missing); cerebellum: 41.0256% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); colon: 64.0000% (minimum 70%, Missing); duodenum: 53.3333% (minimum 75%, Missing); esophagus: 53.3333% (minimum 70%, Missing); heart muscle: 61.5385% (minimum 75%, Missing); hippocampal formation: 66.6667% (minimum 75%, Missing); hypothalamus: 61.5385% (minimum 75%, Missing); kidney: 61.5385% (minimum 75%, Missing); liver: 51.6129% (minimum 75%, Missing); lung: 61.5385% (minimum 75%, Missing); lymph node: 48.4848% (minimum 70%, Missing); midbrain: 69.5652% (minimum 75%, Missing); pancreas: 59.2593% (minimum 75%, Missing); parathyroid gland: 53.3333% (minimum 70%, Missing); pituitary gland: 61.5385% (minimum 75%, Missing); rectum: 64.0000% (minimum 70%, Missing); retina: 29.0909% (minimum 75%, Missing); salivary gland: 51.6129% (minimum 70%, Missing); skeletal muscle: 55.1724% (minimum 75%, Missing); skin: 43.2432% (minimum 65%, Missing); small intestine: 57.1429% (minimum 75%, Missing); smooth muscle: 59.2593% (minimum 75%, Missing); spinal cord: 66.6667% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 57.1429% (minimum 70%, Missing); thymus: 47.0588% (minimum 65%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing); urinary bladder: 57.1429% (minimum 70%, Missing)",-0.217568,-0.215152,-0.459091,0,80,unavailable,3.9,1.7,2.1,"retina: 3.9 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF749,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000186280,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.328788,0.272892,0.191691,0,1,partial,2,0.9,0.7,"retina: 2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KDM4D,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000186300,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 67.4699% (minimum 75%, Missing); cerebellum: 70.0000% (minimum 75%, Missing); cerebral cortex: 73.6842% (minimum 75%, Missing); esophagus: 63.6364% (minimum 70%, Missing); heart muscle: 65.8824% (minimum 75%, Missing); kidney: 65.8824% (minimum 75%, Missing); liver: 71.7949% (minimum 75%, Missing); lung: 72.7273% (minimum 75%, Missing); pancreas: 68.2927% (minimum 75%, Missing); parathyroid gland: 63.6364% (minimum 70%, Missing); retina: 50.9091% (minimum 75%, Missing); skeletal muscle: 68.2927% (minimum 75%, Missing); smooth muscle: 72.7273% (minimum 75%, Missing); thyroid gland: 58.9474% (minimum 65%, Missing); tongue: 55.4455% (minimum 70%, Missing); urinary bladder: 68.2927% (minimum 70%, Missing)",-0.0605263,-0.145545,-0.240909,0,80,unavailable,5.4,4.5,3.9,"retina: 5.4 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 3); esophagus: 3.2 nTPM (protected, limit 3); parathyroid gland: 3.2 nTPM (protected, limit 3); heart muscle: 2.9 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.6 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF555,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000186334,True,compatible,,True,True,True,,0.336486,0.3,0.223333,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC36A3,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000186393,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 35.7143% (minimum 75%, Missing); skin: 8.0645% (minimum 65%, Missing)",-0.569355,0.3,-0.392857,0,6,partial,0.9,0,5.7,"skin: 5.7 nTPM (manageable, limit 5)",,69,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KRT26,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000186446,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.5556% (minimum 65%, Missing); amygdala: 52.6316% (minimum 75%, Missing); basal ganglia: 55.5556% (minimum 75%, Missing); cerebellum: 51.2821% (minimum 75%, Missing); cerebral cortex: 58.8235% (minimum 75%, Missing); colon: 52.6316% (minimum 70%, Missing); esophagus: 68.9655% (minimum 70%, Missing); heart muscle: 62.5000% (minimum 75%, Missing); hippocampal formation: 57.1429% (minimum 75%, Missing); hypothalamus: 60.6061% (minimum 75%, Missing); kidney: 58.8235% (minimum 75%, Missing); lung: 68.9655% (minimum 75%, Missing); midbrain: 55.5556% (minimum 75%, Missing); pancreas: 58.8235% (minimum 75%, Missing); pituitary gland: 74.0741% (minimum 75%, Missing); retina: 51.2821% (minimum 75%, Missing); salivary gland: 64.5161% (minimum 70%, Missing); skeletal muscle: 62.5000% (minimum 75%, Missing); skin: 64.5161% (minimum 65%, Missing); small intestine: 68.9655% (minimum 75%, Missing); smooth muscle: 60.6061% (minimum 75%, Missing); spinal cord: 54.0541% (minimum 75%, Missing); spleen: 64.5161% (minimum 65%, Missing); stomach: 64.5161% (minimum 70%, Missing); thyroid gland: 60.6061% (minimum 65%, Missing); tongue: 64.5161% (minimum 70%, Missing); urinary bladder: 55.5556% (minimum 70%, Missing)",-0.0944444,-0.173684,-0.237179,0,80,unavailable,1.9,1.8,1.6,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF501,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000186451,True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0.3,0.3,0,,,51,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,gallbladder; lymph node; salivary gland; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA12,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000186452,True,compatible,,True,True,True,,0.345261,0.3,0.240566,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TMPRSS12,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000186453,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.297222,0.274286,0.202514,0,80,unavailable,1.7,0.9,1.9,"cerebral cortex: 1.7 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM228A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000186469,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 59.7185% (minimum 75%, Missing); bone marrow: 65.8901% (minimum 75%, Uncertain); cerebral cortex: 56.9437% (minimum 75%, Missing); hippocampal formation: 71.4378% (minimum 75%, Missing); hypothalamus: 60.4053% (minimum 75%, Missing)",0.00850746,0.0324037,-0.180563,0,4,partial,83.4,40.3,57.2,"cerebral cortex: 83.4 nTPM (vital, limit 1); amygdala: 74.4 nTPM (vital, limit 1); hypothalamus: 72.3 nTPM (vital, limit 1); thymus: 57.2 nTPM (manageable, limit 5); bone marrow: 57.1 nTPM (vital, limit 1); spleen: 52.3 nTPM (manageable, limit 5); hippocampal formation: 44.1 nTPM (vital, limit 1); adipose tissue: 44 nTPM (manageable, limit 5); lymph node: 40.3 nTPM (protected, limit 3); choroid plexus: 27.3 nTPM (vital, limit 1); colon: 23.3 nTPM (protected, limit 3); urinary bladder: 19.9 nTPM (protected, limit 3); adrenal gland: 19.2 nTPM (vital, limit 1); small intestine: 18 nTPM (vital, limit 1); lung: 16.7 nTPM (vital, limit 1); smooth muscle: 16.5 nTPM (vital, limit 1); rectum: 16.2 nTPM (protected, limit 3); pituitary gland: 14.5 nTPM (vital, limit 1); stomach: 13.8 nTPM (protected, limit 3); midbrain: 13.8 nTPM (vital, limit 1); retina: 13.3 nTPM (vital, limit 1); basal ganglia: 13 nTPM (vital, limit 1); duodenum: 12.7 nTPM (vital, limit 1); tongue: 12.5 nTPM (protected, limit 3); esophagus: 11.9 nTPM (protected, limit 3); spinal cord: 11.8 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); skin: 6.9 nTPM (manageable, limit 5); salivary gland: 6.7 nTPM (protected, limit 3); pancreas: 6.5 nTPM (vital, limit 1); kidney: 6.4 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GNG2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000186471,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 52.0434% (minimum 75%, Missing)",0.35,0.3,-0.229566,0,5,partial,75.1,0.1,0,"choroid plexus: 75.1 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); amygdala: 4.2 nTPM (vital, limit 1); lung: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),66,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,AKAP14,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000186487,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 23.6842% (minimum 75%, Missing); basal ganglia: 15.8358% (minimum 75%, Missing); cerebellum: 12.9808% (minimum 75%, Missing); cerebral cortex: 12.0536% (minimum 75%, Missing); hippocampal formation: 18.7500% (minimum 75%, Missing); hypothalamus: 22.5941% (minimum 75%, Missing); midbrain: 42.5197% (minimum 75%, Missing); pituitary gland: 27.2727% (minimum 75%, Missing); retina: 54.0000% (minimum 75%, Missing); spinal cord: 64.2857% (minimum 75%, Missing)",0.297368,0.247368,-0.629464,0,80,unavailable,39.4,0.3,0.3,"cerebral cortex: 39.4 nTPM (vital, limit 1); cerebellum: 36.2 nTPM (vital, limit 1); basal ganglia: 28.7 nTPM (vital, limit 1); hippocampal formation: 23.4 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 17.4 nTPM (vital, limit 1); pituitary gland: 14.4 nTPM (vital, limit 1); midbrain: 7.3 nTPM (vital, limit 1); retina: 4.6 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MYT1L,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000186513,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR9Q2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000186562,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.349668,0.299751,0.249503,0,80,unavailable,0.6,0.3,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,DEFB105A,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000186572,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,DEFB107A,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000186579,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,0,routine_complete,0,0.1,0,,,55,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,DEFB106A,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000186583,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.298052,0.283827,0.0629176,0,80,unavailable,8.4,0.6,2,"bone marrow: 8.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATC1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000186599,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,DEFB105B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000186638,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0718543,0.179032,0.00694444,0,80,unavailable,3.5,1.5,4.2,"choroid plexus: 3.5 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KIF24,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000186645,False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"skin: 50.0000% (minimum 55%, Supported)",-0.05,0.3,0.25,9,3,partial,0,0,0.5,,kidney / cells in tubules: Low (Supported); thyroid gland / glandular cells: Low (Supported),53,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,SPDYE17,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000186714,True,compatible,,True,True,True,,0.275,0.3,0.152439,0,80,unavailable,0.4,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC73,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,True,True,True,True,gained,selectivity_revised
ENSG00000186788,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA31D3,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000186790,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"basal ganglia: 53.3333% (minimum 75%, Missing); cerebellum: 66.6667% (minimum 75%, Missing)",0.35,0.188889,-0.216667,0,80,unavailable,0.7,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FOXE3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000186812,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.7143% (minimum 65%, Missing); adrenal gland: 54.5455% (minimum 75%, Missing); amygdala: 59.3156% (minimum 75%, Missing); basal ganglia: 57.9926% (minimum 75%, Missing); cerebellum: 58.2090% (minimum 75%, Missing); cerebral cortex: 51.8272% (minimum 75%, Missing); choroid plexus: 58.8679% (minimum 75%, Missing); colon: 55.7143% (minimum 70%, Missing); duodenum: 60.2317% (minimum 75%, Missing); esophagus: 62.1514% (minimum 70%, Missing); heart muscle: 60.7004% (minimum 75%, Missing); hippocampal formation: 54.7368% (minimum 75%, Missing); hypothalamus: 60.9375% (minimum 75%, Missing); kidney: 58.8679% (minimum 75%, Missing); liver: 60.0000% (minimum 75%, Missing); lung: 60.7004% (minimum 75%, Missing); lymph node: 49.8403% (minimum 70%, Missing); midbrain: 54.3554% (minimum 75%, Missing); pancreas: 56.5217% (minimum 75%, Missing); parathyroid gland: 52.1739% (minimum 70%, Missing); pituitary gland: 57.1429% (minimum 75%, Missing); rectum: 53.7931% (minimum 70%, Missing); retina: 39.2947% (minimum 75%, Missing); salivary gland: 56.5217% (minimum 70%, Missing); skeletal muscle: 58.2090% (minimum 75%, Uncertain); skin: 54.1667% (minimum 65%, Missing); small intestine: 56.1151% (minimum 75%, Missing); smooth muscle: 58.6466% (minimum 75%, Missing); spinal cord: 50.9804% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 54.7368% (minimum 70%, Missing); thymus: 55.1237% (minimum 65%, Missing); thyroid gland: 50.4854% (minimum 65%, Missing); tongue: 59.5420% (minimum 70%, Missing); urinary bladder: 57.5646% (minimum 70%, Missing)",-0.15,-0.201597,-0.357053,0,2,partial,24.1,15.7,15.6,"retina: 24.1 nTPM (vital, limit 1); lymph node: 15.7 nTPM (protected, limit 3); spleen: 15.6 nTPM (manageable, limit 5); thyroid gland: 15.3 nTPM (manageable, limit 5); spinal cord: 15 nTPM (vital, limit 1); cerebral cortex: 14.5 nTPM (vital, limit 1); parathyroid gland: 14.3 nTPM (protected, limit 3); rectum: 13.4 nTPM (protected, limit 3); skin: 13.2 nTPM (manageable, limit 5); midbrain: 13.1 nTPM (vital, limit 1); adrenal gland: 13 nTPM (vital, limit 1); stomach: 12.9 nTPM (protected, limit 3); hippocampal formation: 12.9 nTPM (vital, limit 1); thymus: 12.7 nTPM (manageable, limit 5); adipose tissue: 12.4 nTPM (manageable, limit 5); colon: 12.4 nTPM (protected, limit 3); small intestine: 12.2 nTPM (vital, limit 1); salivary gland: 12 nTPM (protected, limit 3); pancreas: 12 nTPM (vital, limit 1); pituitary gland: 11.7 nTPM (vital, limit 1); urinary bladder: 11.5 nTPM (protected, limit 3); basal ganglia: 11.3 nTPM (vital, limit 1); cerebellum: 11.2 nTPM (vital, limit 1); skeletal muscle: 11.2 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); choroid plexus: 10.9 nTPM (vital, limit 1); kidney: 10.9 nTPM (vital, limit 1); amygdala: 10.7 nTPM (vital, limit 1); tongue: 10.6 nTPM (protected, limit 3); liver: 10.4 nTPM (vital, limit 1); duodenum: 10.3 nTPM (vital, limit 1); lung: 10.1 nTPM (vital, limit 1); heart muscle: 10.1 nTPM (vital, limit 1); hypothalamus: 10 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 3); bone marrow: 4.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: High (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF397,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000186871,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 17.9487% (minimum 75%, Missing); colon: 43.7500% (minimum 70%, Missing); duodenum: 50.0000% (minimum 75%, Missing); esophagus: 38.8889% (minimum 70%, Missing); lymph node: 23.3333% (minimum 70%, Missing); rectum: 38.8889% (minimum 70%, Missing); retina: 63.6364% (minimum 75%, Missing); skin: 53.8462% (minimum 65%, Missing); small intestine: 53.8462% (minimum 75%, Missing); smooth muscle: 70.0000% (minimum 75%, Missing); spleen: 58.3333% (minimum 60%, Approved); stomach: 50.0000% (minimum 70%, Missing); thymus: 16.6667% (minimum 65%, Missing)",-0.483333,-0.466667,-0.570513,0,4,partial,3.2,2.3,3.5,"bone marrow: 3.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ERCC6L,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000186897,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.17,0.27619,0.0384615,0,80,unavailable,1.1,0.1,0.9,"hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C1QL4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000186918,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 61.6587% (minimum 65%, Uncertain); adrenal gland: 74.1329% (minimum 75%, Missing); bone marrow: 58.3618% (minimum 75%, Missing); choroid plexus: 69.7011% (minimum 75%, Missing); colon: 67.4113% (minimum 70%, Missing); duodenum: 71.6480% (minimum 75%, Missing); esophagus: 52.5615% (minimum 70%, Missing); heart muscle: 66.1082% (minimum 75%, Missing); kidney: 69.3243% (minimum 75%, Missing); liver: 58.6957% (minimum 75%, Missing); lung: 72.8693% (minimum 75%, Missing); pancreas: 52.7235% (minimum 75%, Missing); retina: 66.1082% (minimum 75%, Missing); salivary gland: 57.6404% (minimum 70%, Missing); skin: 55.2802% (minimum 65%, Missing); small intestine: 68.1275% (minimum 75%, Missing); stomach: 66.8840% (minimum 70%, Missing); urinary bladder: 66.8840% (minimum 70%, Missing)",-0.0971983,-0.174385,-0.222765,0,3,partial,46,46.3,41.5,"esophagus: 46.3 nTPM (protected, limit 3); pancreas: 46 nTPM (vital, limit 1); skin: 41.5 nTPM (manageable, limit 5); salivary gland: 37.7 nTPM (protected, limit 3); bone marrow: 36.6 nTPM (vital, limit 1); liver: 36.1 nTPM (vital, limit 1); adipose tissue: 31.9 nTPM (manageable, limit 5); retina: 26.3 nTPM (vital, limit 1); heart muscle: 26.3 nTPM (vital, limit 1); stomach: 25.4 nTPM (protected, limit 3); urinary bladder: 25.4 nTPM (protected, limit 3); colon: 24.8 nTPM (protected, limit 3); small intestine: 24 nTPM (vital, limit 1); kidney: 22.7 nTPM (vital, limit 1); choroid plexus: 22.3 nTPM (vital, limit 1); spleen: 21.3 nTPM (manageable, limit 5); lymph node: 20.8 nTPM (protected, limit 3); duodenum: 20.3 nTPM (vital, limit 1); lung: 19.1 nTPM (vital, limit 1); thymus: 18.4 nTPM (manageable, limit 5); thyroid gland: 18 nTPM (manageable, limit 5); adrenal gland: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 3); pituitary gland: 16 nTPM (vital, limit 1); skeletal muscle: 15.7 nTPM (vital, limit 1); basal ganglia: 15.7 nTPM (vital, limit 1); amygdala: 13.9 nTPM (vital, limit 1); rectum: 13.5 nTPM (protected, limit 3); tongue: 13.4 nTPM (protected, limit 3); cerebral cortex: 12.9 nTPM (vital, limit 1); cerebellum: 12.3 nTPM (vital, limit 1); hippocampal formation: 11.4 nTPM (vital, limit 1); midbrain: 11.2 nTPM (vital, limit 1); hypothalamus: 9.3 nTPM (vital, limit 1); spinal cord: 9.2 nTPM (vital, limit 1); smooth muscle: 9.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF395,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000186952,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.17,0.191304,0.0741206,0,80,unavailable,3.5,2,3.6,"kidney: 3.5 nTPM (vital, limit 1); retina: 3.5 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TMEM232,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000186976,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.237218,0.211197,0.133895,0,80,unavailable,3.1,2.3,3,"choroid plexus: 3.1 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EFCAB6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000187003,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ACTL7A,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000187005,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,KRTAP21-1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000187017,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 61.4747% (minimum 75%, Missing); kidney: 69.6146% (minimum 75%, Missing); liver: 52.8507% (minimum 75%, Missing); retina: 55.1900% (minimum 75%, Missing); small intestine: 61.7712% (minimum 75%, Missing)",0.11128,0.10884,-0.221493,0,3,partial,125.7,33.3,89.6,"liver: 125.7 nTPM (vital, limit 1); retina: 114.4 nTPM (vital, limit 1); skin: 89.6 nTPM (manageable, limit 30); duodenum: 88.3 nTPM (vital, limit 1); small intestine: 87.2 nTPM (vital, limit 1); kidney: 61.5 nTPM (vital, limit 1); pituitary gland: 40.9 nTPM (vital, limit 1); esophagus: 33.3 nTPM (protected, limit 3); bone marrow: 27.6 nTPM (vital, limit 6); colon: 27.3 nTPM (protected, limit 3); parathyroid gland: 26 nTPM (protected, limit 3); cerebellum: 20.5 nTPM (vital, limit 1); rectum: 6.6 nTPM (protected, limit 3); adrenal gland: 5.5 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: High (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / glandular cells: High (Enhanced); small intestine / glandular cells: High (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ESPN,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000187024,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 51.2121% (minimum 65%, Missing); adrenal gland: 40.6250% (minimum 75%, Missing); amygdala: 46.1749% (minimum 75%, Missing); basal ganglia: 50.0000% (minimum 75%, Missing); cerebral cortex: 47.4719% (minimum 75%, Missing); choroid plexus: 62.8253% (minimum 75%, Missing); colon: 59.0909% (minimum 70%, Missing); esophagus: 62.5926% (minimum 70%, Missing); heart muscle: 48.8439% (minimum 75%, Missing); hippocampal formation: 50.7508% (minimum 75%, Missing); hypothalamus: 52.0000% (minimum 75%, Missing); kidney: 39.3939% (minimum 75%, Missing); liver: 48.9855% (minimum 75%, Missing); lung: 57.8767% (minimum 75%, Missing); midbrain: 50.2976% (minimum 75%, Missing); pancreas: 45.4301% (minimum 75%, Missing); parathyroid gland: 69.8347% (minimum 70%, Missing); pituitary gland: 49.4152% (minimum 75%, Missing); salivary gland: 60.1423% (minimum 70%, Missing); skeletal muscle: 46.8144% (minimum 75%, Missing); skin: 41.3203% (minimum 65%, Missing); small intestine: 69.5473% (minimum 75%, Missing); spinal cord: 62.5926% (minimum 75%, Missing); spleen: 57.8767% (minimum 65%, Missing); stomach: 54.5161% (minimum 70%, Missing); thyroid gland: 46.4286% (minimum 65%, Missing); urinary bladder: 57.4830% (minimum 70%, Missing)",-0.236797,-0.154839,-0.356061,0,6,partial,26,14.1,24,"kidney: 26 nTPM (vital, limit 1); adrenal gland: 24.7 nTPM (vital, limit 1); skin: 24 nTPM (manageable, limit 5); pancreas: 20.3 nTPM (vital, limit 1); amygdala: 19.7 nTPM (vital, limit 1); thyroid gland: 19.5 nTPM (manageable, limit 5); skeletal muscle: 19.2 nTPM (vital, limit 1); cerebral cortex: 18.7 nTPM (vital, limit 1); heart muscle: 17.7 nTPM (vital, limit 1); liver: 17.6 nTPM (vital, limit 1); pituitary gland: 17.3 nTPM (vital, limit 1); basal ganglia: 16.9 nTPM (vital, limit 1); midbrain: 16.7 nTPM (vital, limit 1); hippocampal formation: 16.4 nTPM (vital, limit 1); adipose tissue: 16.1 nTPM (manageable, limit 5); hypothalamus: 15.6 nTPM (vital, limit 1); stomach: 14.1 nTPM (protected, limit 3); urinary bladder: 12.5 nTPM (protected, limit 3); lung: 12.3 nTPM (vital, limit 1); spleen: 12.3 nTPM (manageable, limit 5); colon: 11.7 nTPM (protected, limit 3); salivary gland: 11.2 nTPM (protected, limit 3); esophagus: 10.1 nTPM (protected, limit 3); spinal cord: 10.1 nTPM (vital, limit 1); choroid plexus: 10 nTPM (vital, limit 1); small intestine: 7.4 nTPM (vital, limit 1); parathyroid gland: 7.3 nTPM (protected, limit 3); cerebellum: 4.6 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); smooth muscle: 3.4 nTPM (vital, limit 1); lymph node: 3.2 nTPM (protected, limit 3); tongue: 3.1 nTPM (protected, limit 3); retina: 2.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PTRH1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000187026,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 55.1724% (minimum 65%, Missing)",-0.0982759,0.3,0.25,0,80,unavailable,0,0,1.3,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,KRTAP21-2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000187033,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"lymph node: 33.3333% (minimum 70%, Missing); retina: 0.0769% (minimum 75%, Missing)",0.35,-0.366667,-0.749231,0,80,unavailable,130,0.2,0,"retina: 130 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SAMD7,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000187066,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.345146,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TMEM262,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000187080,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 33.3333% (minimum 75%, Missing)",0.35,0.3,-0.416667,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR2AK2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000187082,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,52,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,DEFB106B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000187105,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.265517,0.180952,0.0485612,0,4,partial,2.8,1.5,3.4,"retina: 2.8 nTPM (vital, limit 1)",colon / peripheral nerve/ganglion: Low (Enhanced); kidney / proximal tubules (microvilli): High (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HEATR4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000187122,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 8.2524% (minimum 75%, Missing); basal ganglia: 6.8826% (minimum 75%, Missing); cerebellum: 62.9630% (minimum 75%, Missing); cerebral cortex: 4.7753% (minimum 75%, Missing); hippocampal formation: 7.8341% (minimum 75%, Missing); hypothalamus: 10.6250% (minimum 75%, Missing); midbrain: 23.6111% (minimum 75%, Missing); pituitary gland: 11.4865% (minimum 75%, Missing); retina: 70.8333% (minimum 75%, Missing); spinal cord: 45.9459% (minimum 75%, Missing); thymus: 42.5000% (minimum 65%, Missing); thyroid gland: 41.4634% (minimum 65%, Missing)",-0.235366,0.0727273,-0.702247,0,80,unavailable,33.9,0.5,2.4,"cerebral cortex: 33.9 nTPM (vital, limit 1); basal ganglia: 23 nTPM (vital, limit 1); hippocampal formation: 20 nTPM (vital, limit 1); amygdala: 18.9 nTPM (vital, limit 1); hypothalamus: 14.3 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); midbrain: 5.5 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,appendix; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLIT1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000187144,True,compatible,,True,True,True,,0.311039,0.286667,0.152439,0,80,unavailable,0.8,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA21,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000187166,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,,0.349053,0.298108,0.246693,0,8,partial,0.7,0.4,0.3,,adipose tissue / adipocytes: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: High (Approved),47,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 2 / epidermal cells; spleen; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,H1-7,current_adaptive,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000187186,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 74.8355% (minimum 75%, Missing)",0.342668,0.229389,-0.00164517,0,2,partial,95.6,21.6,13.2,"basal ganglia: 95.6 nTPM (vital, limit 1); cerebral cortex: 75.4 nTPM (vital, limit 6); pituitary gland: 59 nTPM (vital, limit 1); amygdala: 57.3 nTPM (vital, limit 1); hippocampal formation: 56.4 nTPM (vital, limit 1); hypothalamus: 47.3 nTPM (vital, limit 1); midbrain: 46.6 nTPM (vital, limit 1); skeletal muscle: 35.4 nTPM (vital, limit 6); cerebellum: 33 nTPM (vital, limit 6); choroid plexus: 28.6 nTPM (vital, limit 1); heart muscle: 27 nTPM (vital, limit 6); spinal cord: 26.7 nTPM (vital, limit 1); tongue: 21.6 nTPM (protected, limit 3); kidney: 14.2 nTPM (vital, limit 6); adrenal gland: 9.4 nTPM (vital, limit 6); pancreas: 8.5 nTPM (vital, limit 6); liver: 6.6 nTPM (vital, limit 6); retina: 6.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000187186,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,False,False,False,False,unchanged,
ENSG00000187187,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.159816,0.168421,0.0357143,0,80,unavailable,3.6,2,3.1,"liver: 3.6 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); adrenal gland: 2.7 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF546,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000187191,True,compatible,,True,True,True,,0.223529,0.05,0.25,0,1,partial,0,0.6,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DAZ3,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000187223,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 4.4156% (minimum 65%, Missing)",-0.605844,0.3,0.0140449,0,80,unavailable,2.1,0,147.2,"skin: 147.2 nTPM (manageable, limit 5); skeletal muscle: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LCE2D,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000187268,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"spleen: 10.1449% (minimum 65%, Missing)",-0.548551,0.254545,0.0735294,0,80,unavailable,0.9,0.2,37.2,"spleen: 37.2 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM9C,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000187372,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 57.6923% (minimum 65%, Missing); adrenal gland: 55.5556% (minimum 75%, Missing); basal ganglia: 71.4286% (minimum 75%, Missing); cerebellum: 62.5000% (minimum 75%, Missing); cerebral cortex: 57.6923% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); esophagus: 68.1818% (minimum 70%, Missing); heart muscle: 51.7241% (minimum 75%, Missing); kidney: 65.2174% (minimum 75%, Missing); lung: 65.2174% (minimum 75%, Missing); pancreas: 44.1176% (minimum 75%, Missing); parathyroid gland: 68.1818% (minimum 70%, Missing); pituitary gland: 51.7241% (minimum 75%, Missing); retina: 55.5556% (minimum 75%, Missing); salivary gland: 51.7241% (minimum 70%, Missing); skin: 45.4545% (minimum 65%, Missing); smooth muscle: 53.5714% (minimum 75%, Missing); spinal cord: 71.4286% (minimum 75%, Missing); stomach: 68.1818% (minimum 70%, Missing); tongue: 68.1818% (minimum 70%, Missing); urinary bladder: 65.2174% (minimum 70%, Missing)",-0.195455,-0.182759,-0.308824,0,80,unavailable,1.9,1.4,1.8,"pancreas: 1.9 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHB13,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000187475,True,compatible,family_exclusion,True,True,True,,0.35,0.3,0.159091,0,1,partial,0.1,0,0,,,54,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,H1-6,current_adaptive,False,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000187479,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.0456% (minimum 65%, Missing); heart muscle: 73.5918% (minimum 75%, Missing); lung: 66.4559% (minimum 75%, Missing)",-0.0395437,0.0574428,-0.0854413,0,4,partial,366,232.2,462.7,"adipose tissue: 462.7 nTPM (manageable, limit 5); lung: 366 nTPM (vital, limit 1); heart muscle: 260.2 nTPM (vital, limit 1); stomach: 232.2 nTPM (protected, limit 3); kidney: 219.4 nTPM (vital, limit 1); adrenal gland: 192.8 nTPM (vital, limit 1); liver: 174.8 nTPM (vital, limit 1); urinary bladder: 170.5 nTPM (protected, limit 3); colon: 145.8 nTPM (protected, limit 3); small intestine: 126.4 nTPM (vital, limit 1); pituitary gland: 123.1 nTPM (vital, limit 1); thyroid gland: 115.7 nTPM (manageable, limit 5); skeletal muscle: 107 nTPM (vital, limit 1); skin: 94 nTPM (manageable, limit 5); hypothalamus: 78.3 nTPM (vital, limit 1); midbrain: 64.7 nTPM (vital, limit 1); pancreas: 58.8 nTPM (vital, limit 1); spleen: 53.1 nTPM (manageable, limit 5); spinal cord: 45.8 nTPM (vital, limit 1); esophagus: 43.5 nTPM (protected, limit 3); amygdala: 42.2 nTPM (vital, limit 1); basal ganglia: 40.9 nTPM (vital, limit 1); cerebral cortex: 36.5 nTPM (vital, limit 1); hippocampal formation: 36.3 nTPM (vital, limit 1); choroid plexus: 31.3 nTPM (vital, limit 1); smooth muscle: 27.4 nTPM (vital, limit 1); salivary gland: 21.5 nTPM (protected, limit 3); cerebellum: 19.2 nTPM (vital, limit 1); duodenum: 19 nTPM (vital, limit 1); tongue: 9.9 nTPM (protected, limit 3); rectum: 8.1 nTPM (protected, limit 3); lymph node: 6.6 nTPM (protected, limit 3); bone marrow: 4.8 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 3); retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: High (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C11orf96,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000187516,True,compatible,,True,True,True,,0.35,0.3,0.247674,0,1,partial,0.1,0,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,H2AP,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000187533,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"pancreas: 31.2500% (minimum 60%, Enhanced); salivary gland: 0.0466% (minimum 70%, Missing)",0.35,-0.699534,-0.2875,0,2,partial,1.1,1071.7,0,"salivary gland: 1071.7 nTPM (protected, limit 3)",salivary gland / glandular cells: High (Enhanced),54,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; salivary gland / glandular cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRR27,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000187537,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,POTEG,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000187569,True,compatible,,True,True,True,,0.31875,0.26875,0.111111,0,80,unavailable,0.5,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DPPA3,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000187581,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.35,0.298652,0.247308,0,5,partial,0.4,0.1,0,,bone marrow / hematopoietic cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node / germinal center cells; skin 1 / fibroblasts; skin 2 / epidermal cells; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,COX8C,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000187607,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 66.9565% (minimum 75%, Missing); amygdala: 72.9858% (minimum 75%, Missing); basal ganglia: 73.6842% (minimum 75%, Missing); cerebellum: 69.6833% (minimum 75%, Missing); cerebral cortex: 65.5319% (minimum 75%, Missing); choroid plexus: 67.5439% (minimum 75%, Missing); esophagus: 61.3546% (minimum 70%, Missing); heart muscle: 50.6579% (minimum 75%, Missing); hippocampal formation: 70.6422% (minimum 75%, Missing); hypothalamus: 73.3333% (minimum 75%, Missing); kidney: 67.2489% (minimum 75%, Missing); lymph node: 64.1667% (minimum 70%, Missing); midbrain: 67.5439% (minimum 75%, Missing); parathyroid gland: 52.5597% (minimum 70%, Missing); pituitary gland: 73.6842% (minimum 75%, Missing); retina: 57.4627% (minimum 75%, Missing); smooth muscle: 59.2308% (minimum 75%, Missing); spinal cord: 61.6000% (minimum 75%, Missing); thymus: 55.0000% (minimum 65%, Missing); thyroid gland: 60.3922% (minimum 65%, Missing); tongue: 62.0968% (minimum 70%, Missing); urinary bladder: 64.1667% (minimum 70%, Missing)",-0.1,-0.174403,-0.243421,0,80,unavailable,15,13.9,12.6,"heart muscle: 15 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 3); thymus: 12.6 nTPM (manageable, limit 5); retina: 11.4 nTPM (vital, limit 1); smooth muscle: 10.6 nTPM (vital, limit 1); thyroid gland: 10.1 nTPM (manageable, limit 5); esophagus: 9.7 nTPM (protected, limit 3); spinal cord: 9.6 nTPM (vital, limit 1); tongue: 9.4 nTPM (protected, limit 3); urinary bladder: 8.6 nTPM (protected, limit 3); lymph node: 8.6 nTPM (protected, limit 3); cerebral cortex: 8.1 nTPM (vital, limit 1); adrenal gland: 7.6 nTPM (vital, limit 1); kidney: 7.5 nTPM (vital, limit 1); midbrain: 7.4 nTPM (vital, limit 1); choroid plexus: 7.4 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); hippocampal formation: 6.4 nTPM (vital, limit 1); amygdala: 5.7 nTPM (vital, limit 1); hypothalamus: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 3); skin: 5.6 nTPM (manageable, limit 5); spleen: 5.5 nTPM (manageable, limit 5); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.5 nTPM (vital, limit 1); adipose tissue: 5.3 nTPM (manageable, limit 5); stomach: 5.1 nTPM (protected, limit 3); lung: 4.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 3); rectum: 4.6 nTPM (protected, limit 3); liver: 4 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); small intestine: 3.7 nTPM (vital, limit 1); duodenum: 3.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF286A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000187624,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.245149,0.23617,0.103731,0,3,partial,9.8,3.9,6.7,"basal ganglia: 9.8 nTPM (vital, limit 1); cerebral cortex: 8.4 nTPM (vital, limit 1); kidney: 8.2 nTPM (vital, limit 1); hypothalamus: 8 nTPM (vital, limit 1); pituitary gland: 6.8 nTPM (vital, limit 1); hippocampal formation: 6.7 nTPM (vital, limit 1); thyroid gland: 6.7 nTPM (manageable, limit 5); amygdala: 6.5 nTPM (vital, limit 1); midbrain: 5 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); choroid plexus: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 2); colon: 3.9 nTPM (protected, limit 3); heart muscle: 3.6 nTPM (vital, limit 1); cerebellum: 3.3 nTPM (vital, limit 2); spinal cord: 3.3 nTPM (vital, limit 1); esophagus: 3.1 nTPM (protected, limit 3); pancreas: 2.8 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); liver: 2.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LIAT1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000187658,True,compatible,,True,True,True,,0.35,0.253552,0.230337,0,80,unavailable,0.7,1.7,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C5orf52,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000187690,True,compatible,,True,True,True,,0.35,0.3,0.100746,0,2,partial,1.6,0.1,0.5,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EZHIP,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016,False,True,True,True,False,gained,selectivity_revised
ENSG00000187726,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 66.3660% (minimum 75%, Missing)",0.35,0.3,-0.0863402,0,6,partial,26.1,2,1.2,"choroid plexus: 26.1 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAJB13,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000187736,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.7761% (minimum 65%, Missing); adrenal gland: 66.3900% (minimum 75%, Missing); cerebellum: 71.1111% (minimum 75%, Missing); colon: 54.0541% (minimum 70%, Missing); duodenum: 70.1754% (minimum 75%, Missing); esophagus: 69.5652% (minimum 70%, Missing); heart muscle: 72.7273% (minimum 75%, Missing); kidney: 56.1404% (minimum 75%, Missing); liver: 66.9456% (minimum 75%, Missing); lung: 70.4846% (minimum 75%, Missing); pancreas: 66.1157% (minimum 75%, Missing); rectum: 64.7773% (minimum 70%, Missing); skeletal muscle: 49.2308% (minimum 75%, Missing); small intestine: 57.5540% (minimum 75%, Missing); smooth muscle: 72.0721% (minimum 75%, Missing); stomach: 64.7773% (minimum 70%, Missing); urinary bladder: 61.3027% (minimum 70%, Missing)",-0.0322394,-0.159459,-0.257692,0,1,partial,16.5,13.6,9.9,"skeletal muscle: 16.5 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 3); kidney: 12.5 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); urinary bladder: 10.1 nTPM (protected, limit 3); adipose tissue: 9.9 nTPM (manageable, limit 5); rectum: 8.7 nTPM (protected, limit 3); stomach: 8.7 nTPM (protected, limit 3); skin: 8.2 nTPM (manageable, limit 5); pancreas: 8.2 nTPM (vital, limit 1); adrenal gland: 8.1 nTPM (vital, limit 1); liver: 7.9 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 3); duodenum: 6.8 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); lung: 6.7 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); tongue: 6.2 nTPM (protected, limit 3); smooth muscle: 6.2 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); thymus: 5.3 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 3); spinal cord: 3.7 nTPM (vital, limit 1); bone marrow: 3.2 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 3); hypothalamus: 3.1 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); retina: 2.8 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NHEJ1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000187741,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 65.0155% (minimum 75%, Missing)",0.113636,0.0317073,-0.0998452,0,80,unavailable,11.3,7.7,6.5,"bone marrow: 11.3 nTPM (vital, limit 1); lymph node: 7.7 nTPM (protected, limit 3); spleen: 6.5 nTPM (manageable, limit 5); esophagus: 6.4 nTPM (protected, limit 3); liver: 5.9 nTPM (vital, limit 1); small intestine: 5.5 nTPM (vital, limit 1); cerebellum: 5.2 nTPM (vital, limit 1); colon: 4 nTPM (protected, limit 3); duodenum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); kidney: 2.8 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FANCA,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000187753,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.335222,0.27561,0.142857,0,80,unavailable,2.4,0.5,0.3,"bone marrow: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C9orf153,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000187754,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 33.3333% (minimum 70%, Approved); cerebral cortex: 33.3333% (minimum 70%, Approved); duodenum: 50.0000% (minimum 70%, Approved); esophagus: 25.0000% (minimum 65%, Approved); lung: 50.0000% (minimum 70%, Approved); lymph node: 50.0000% (minimum 65%, Approved); retina: 14.2857% (minimum 75%, Missing); salivary gland: 25.0000% (minimum 65%, Approved); skin: 25.0000% (minimum 60%, Approved); spleen: 50.0000% (minimum 60%, Approved); stomach: 50.0000% (minimum 65%, Approved)",-0.35,-0.4,-0.607143,0,2,partial,0.6,0.3,0.3,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SSX7,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000187772,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.226816,0,4,partial,1.5,0.1,0.2,"retina: 1.5 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LIN28B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,"Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics",False,False,False,False,False,unchanged,
ENSG00000187775,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 69.2308% (minimum 75%, Missing)",0.35,0.3,-0.0576923,0,1,partial,2.4,0,0.4,"retina: 2.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAH17,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000187790,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 66.3265% (minimum 75%, Missing)",0.0642857,0.0831325,-0.0867347,0,80,unavailable,3.3,1.8,2.6,"bone marrow: 3.3 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FANCM,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000187791,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.339437,0.282517,0.225694,0,80,unavailable,0.7,0.5,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,SPATA31F3,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000187792,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.0930% (minimum 75%, Missing); bone marrow: 65.9574% (minimum 75%, Missing); cerebellum: 68.8889% (minimum 75%, Missing); cerebral cortex: 72.0930% (minimum 75%, Missing); colon: 68.8889% (minimum 70%, Missing); heart muscle: 67.3913% (minimum 75%, Missing); lung: 72.0930% (minimum 75%, Missing); lymph node: 68.8889% (minimum 70%, Missing); pancreas: 64.5833% (minimum 75%, Missing); parathyroid gland: 59.6154% (minimum 70%, Missing); pituitary gland: 65.9574% (minimum 75%, Missing); retina: 51.6667% (minimum 75%, Missing); salivary gland: 60.7843% (minimum 70%, Missing); skeletal muscle: 55.3571% (minimum 75%, Missing); small intestine: 72.0930% (minimum 75%, Missing); smooth muscle: 65.9574% (minimum 75%, Missing); spinal cord: 73.8095% (minimum 75%, Missing); thyroid gland: 63.2653% (minimum 65%, Missing); tongue: 59.6154% (minimum 70%, Missing)",-0.0173469,-0.103846,-0.233333,0,80,unavailable,2.9,2.1,1.8,"retina: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF70,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000187806,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TMEM202,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000187815,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.8148% (minimum 65%, Missing); adrenal gland: 72.9167% (minimum 75%, Missing); amygdala: 53.0303% (minimum 75%, Missing); basal ganglia: 52.2388% (minimum 75%, Missing); bone marrow: 64.8148% (minimum 75%, Missing); cerebellum: 60.3448% (minimum 75%, Missing); cerebral cortex: 60.3448% (minimum 75%, Missing); choroid plexus: 64.8148% (minimum 75%, Missing); colon: 57.3770% (minimum 70%, Missing); duodenum: 66.0377% (minimum 75%, Missing); esophagus: 64.8148% (minimum 70%, Missing); heart muscle: 67.3077% (minimum 75%, Missing); hippocampal formation: 54.6875% (minimum 75%, Missing); hypothalamus: 58.3333% (minimum 75%, Missing); kidney: 62.5000% (minimum 75%, Missing); liver: 64.8148% (minimum 75%, Missing); lung: 60.3448% (minimum 75%, Missing); lymph node: 55.5556% (minimum 70%, Missing); midbrain: 53.8462% (minimum 75%, Missing); pancreas: 59.3220% (minimum 75%, Missing); parathyroid gland: 59.3220% (minimum 70%, Missing); pituitary gland: 72.9167% (minimum 75%, Missing); rectum: 64.8148% (minimum 70%, Missing); retina: 63.6364% (minimum 75%, Missing); salivary gland: 67.3077% (minimum 70%, Missing); skin: 56.4516% (minimum 65%, Missing); small intestine: 60.3448% (minimum 75%, Missing); smooth muscle: 58.3333% (minimum 75%, Missing); spinal cord: 47.2973% (minimum 75%, Missing); spleen: 53.0303% (minimum 65%, Missing); stomach: 63.6364% (minimum 70%, Missing); thymus: 54.6875% (minimum 65%, Missing); thyroid gland: 63.6364% (minimum 65%, Missing); urinary bladder: 57.3770% (minimum 70%, Missing)",-0.119697,-0.144444,-0.277027,0,80,unavailable,3.9,2.8,3.1,"spinal cord: 3.9 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); midbrain: 3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); choroid plexus: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZFP69,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000187833,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C2orf78,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000187860,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.234488,0.224138,0.0621212,0,80,unavailable,6.2,2.2,3.5,"choroid plexus: 6.2 nTPM (vital, limit 1); hypothalamus: 6 nTPM (vital, limit 1); pituitary gland: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); cerebral cortex: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC157,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000187918,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR51I2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000187969,True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZCCHC13,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000187987,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"parathyroid gland: 61.1111% (minimum 70%, Uncertain); retina: 47.8261% (minimum 75%, Missing); salivary gland: 68.7500% (minimum 70%, Missing); thyroid gland: 57.8947% (minimum 65%, Missing)",-0.0710526,-0.0888889,-0.271739,0,2,partial,1.2,0.7,0.8,"retina: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: High (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZSCAN23,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000188032,True,compatible,,True,True,True,,0.334615,0.269697,0.234615,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C19orf67,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000188033,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 68.9655% (minimum 75%, Missing); bone marrow: 55.5556% (minimum 75%, Missing); cerebellum: 74.0741% (minimum 75%, Missing); cerebral cortex: 51.2821% (minimum 75%, Missing); choroid plexus: 58.8235% (minimum 75%, Missing); colon: 64.5161% (minimum 70%, Missing); duodenum: 64.5161% (minimum 75%, Missing); heart muscle: 71.4286% (minimum 75%, Missing); kidney: 62.5000% (minimum 75%, Missing); liver: 54.0541% (minimum 75%, Missing); lung: 60.6061% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); pancreas: 58.8235% (minimum 75%, Missing); parathyroid gland: 52.6316% (minimum 70%, Missing); rectum: 62.5000% (minimum 70%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 64.5161% (minimum 70%, Missing); skeletal muscle: 68.9655% (minimum 75%, Missing); skin: 54.0541% (minimum 65%, Missing); small intestine: 71.4286% (minimum 75%, Missing); smooth muscle: 68.9655% (minimum 75%, Missing); spleen: 46.5116% (minimum 65%, Missing); stomach: 64.5161% (minimum 70%, Missing); thymus: 48.7805% (minimum 65%, Missing); thyroid gland: 47.6190% (minimum 65%, Missing); tongue: 66.6667% (minimum 70%, Missing); urinary bladder: 68.9655% (minimum 70%, Missing)",-0.184884,-0.2,-0.25,0,80,unavailable,2,2,2.3,"retina: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF490,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000188050,True,compatible,,True,True,True,,0.345146,0.292736,0.240338,0,80,unavailable,0.4,0.3,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RNF133,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000188092,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.3540% (minimum 65%, Missing); adrenal gland: 60.0000% (minimum 75%, Missing); amygdala: 67.1053% (minimum 75%, Missing); basal ganglia: 67.1053% (minimum 75%, Missing); cerebellum: 60.0000% (minimum 75%, Missing); cerebral cortex: 61.0778% (minimum 75%, Missing); colon: 66.2338% (minimum 70%, Missing); esophagus: 64.9682% (minimum 70%, Missing); heart muscle: 64.9682% (minimum 75%, Missing); hippocampal formation: 68.0000% (minimum 75%, Missing); hypothalamus: 60.0000% (minimum 75%, Missing); kidney: 45.9459% (minimum 75%, Missing); liver: 59.3023% (minimum 75%, Missing); lung: 65.8065% (minimum 75%, Missing); midbrain: 63.7500% (minimum 75%, Missing); pancreas: 70.3448% (minimum 75%, Missing); pituitary gland: 68.4564% (minimum 75%, Missing); salivary gland: 58.9595% (minimum 70%, Missing); skeletal muscle: 54.5455% (minimum 75%, Missing); skin: 55.4348% (minimum 65%, Missing); small intestine: 59.6491% (minimum 75%, Missing); spinal cord: 56.9832% (minimum 75%, Missing); stomach: 62.1951% (minimum 70%, Missing); tongue: 64.1509% (minimum 70%, Missing); urinary bladder: 62.5767% (minimum 70%, Missing)",-0.0956522,-0.110405,-0.290541,0,80,unavailable,12,7.1,8.2,"kidney: 12 nTPM (vital, limit 1); skeletal muscle: 8.5 nTPM (vital, limit 1); skin: 8.2 nTPM (manageable, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); salivary gland: 7.1 nTPM (protected, limit 3); liver: 7 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); cerebellum: 6.8 nTPM (vital, limit 1); adrenal gland: 6.8 nTPM (vital, limit 1); cerebral cortex: 6.5 nTPM (vital, limit 1); stomach: 6.2 nTPM (protected, limit 3); urinary bladder: 6.1 nTPM (protected, limit 3); adipose tissue: 5.9 nTPM (manageable, limit 5); midbrain: 5.8 nTPM (vital, limit 1); tongue: 5.7 nTPM (protected, limit 3); esophagus: 5.5 nTPM (protected, limit 3); heart muscle: 5.5 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); colon: 5.2 nTPM (protected, limit 3); amygdala: 5 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); hippocampal formation: 4.8 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GPR89B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000188120,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0.2,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DAZ1,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000188155,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 7.4074% (minimum 65%, Missing)",-0.575926,0.3,0.25,0,80,unavailable,0,0,2.5,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,KRTAP10-6,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000188162,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"pituitary gland: 38.0952% (minimum 75%, Missing); retina: 61.5385% (minimum 75%, Missing)",0.35,0.3,-0.369048,0,80,unavailable,1.3,0,0,"pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OTOG,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000188163,True,compatible,,True,True,True,,0.35,0.3,0.235,0,3,partial,1.8,0.4,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CIMIP2A,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,False,gained,selectivity_revised
ENSG00000188167,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 70.5882% (minimum 75%, Missing); bone marrow: 18.1818% (minimum 75%, Missing); cerebral cortex: 54.5455% (minimum 75%, Missing); choroid plexus: 70.5882% (minimum 75%, Missing); colon: 57.1429% (minimum 70%, Missing); duodenum: 50.0000% (minimum 75%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 75.0000% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); liver: 70.5882% (minimum 75%, Missing); lung: 54.5455% (minimum 75%, Missing); lymph node: 52.1739% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 40.0000% (minimum 70%, Missing); rectum: 50.0000% (minimum 70%, Missing); retina: 30.7692% (minimum 75%, Missing); salivary gland: 63.1579% (minimum 70%, Missing); skin: 52.1739% (minimum 65%, Missing); small intestine: 52.1739% (minimum 75%, Missing); smooth muscle: 60.0000% (minimum 70%, Approved); spleen: 44.4444% (minimum 65%, Missing); stomach: 48.0000% (minimum 70%, Missing); thyroid gland: 54.5455% (minimum 65%, Missing); urinary bladder: 63.1579% (minimum 70%, Missing)",-0.205556,-0.3,-0.568182,0,1,partial,5.4,1.8,1.5,"bone marrow: 5.4 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TMPPE,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000188171,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.0884% (minimum 75%, Missing); cerebral cortex: 73.5915% (minimum 75%, Missing); heart muscle: 68.7500% (minimum 75%, Missing); kidney: 66.7732% (minimum 75%, Uncertain); lymph node: 63.9144% (minimum 70%, Uncertain); parathyroid gland: 51.9900% (minimum 70%, Missing); retina: 74.6429% (minimum 75%, Missing); smooth muscle: 70.3704% (minimum 75%, Missing); thyroid gland: 49.0610% (minimum 65%, Missing); urinary bladder: 60.2305% (minimum 70%, Missing)",-0.15939,-0.1801,-0.0822684,0,3,partial,10.4,19.3,21.7,"thyroid gland: 21.7 nTPM (manageable, limit 5); parathyroid gland: 19.3 nTPM (protected, limit 3); urinary bladder: 13.8 nTPM (protected, limit 3); lymph node: 11.8 nTPM (protected, limit 3); kidney: 10.4 nTPM (vital, limit 1); heart muscle: 9.5 nTPM (vital, limit 1); skin: 9 nTPM (manageable, limit 5); smooth muscle: 8.8 nTPM (vital, limit 1); adrenal gland: 8.5 nTPM (vital, limit 1); thymus: 8.2 nTPM (manageable, limit 5); stomach: 7.8 nTPM (protected, limit 3); cerebral cortex: 7.5 nTPM (vital, limit 1); retina: 7.1 nTPM (vital, limit 1); adipose tissue: 7 nTPM (manageable, limit 5); pancreas: 6.8 nTPM (vital, limit 1); salivary gland: 6.7 nTPM (protected, limit 3); spleen: 6.7 nTPM (manageable, limit 5); esophagus: 6 nTPM (protected, limit 3); tongue: 5.6 nTPM (protected, limit 3); liver: 5.3 nTPM (vital, limit 1); lung: 4.9 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); choroid plexus: 4.1 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.6 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); pituitary gland: 3.4 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3); cerebellum: 2.5 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF626,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000188295,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.6279% (minimum 65%, Missing); adrenal gland: 74.6479% (minimum 75%, Missing); bone marrow: 31.5476% (minimum 75%, Missing); cerebellum: 64.6341% (minimum 75%, Missing); cerebral cortex: 62.3529% (minimum 75%, Missing); choroid plexus: 74.6479% (minimum 75%, Missing); colon: 59.5506% (minimum 70%, Missing); duodenum: 65.4321% (minimum 75%, Missing); esophagus: 68.8312% (minimum 70%, Missing); heart muscle: 68.8312% (minimum 75%, Missing); kidney: 59.5506% (minimum 75%, Missing); liver: 71.6216% (minimum 75%, Missing); lung: 62.3529% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); pancreas: 56.3830% (minimum 75%, Missing); parathyroid gland: 56.3830% (minimum 70%, Missing); rectum: 60.9195% (minimum 70%, Missing); retina: 51.9608% (minimum 75%, Missing); salivary gland: 65.4321% (minimum 70%, Missing); skeletal muscle: 73.6111% (minimum 75%, Missing); small intestine: 69.7368% (minimum 75%, Missing); smooth muscle: 60.2273% (minimum 75%, Missing); spleen: 57.6087% (minimum 65%, Missing); stomach: 62.3529% (minimum 70%, Missing); thymus: 38.1295% (minimum 65%, Missing); thyroid gland: 52.4752% (minimum 65%, Missing); tongue: 60.2273% (minimum 70%, Missing); urinary bladder: 67.0886% (minimum 70%, Missing)",-0.268705,-0.2,-0.434524,0,80,unavailable,11.5,5.3,8.6,"bone marrow: 11.5 nTPM (vital, limit 1); thymus: 8.6 nTPM (manageable, limit 5); lymph node: 5.3 nTPM (protected, limit 3); retina: 4.9 nTPM (vital, limit 1); parathyroid gland: 4.1 nTPM (protected, limit 3); pancreas: 4.1 nTPM (vital, limit 1); kidney: 3.6 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); tongue: 3.5 nTPM (protected, limit 3); smooth muscle: 3.5 nTPM (vital, limit 1); rectum: 3.4 nTPM (protected, limit 3); stomach: 3.2 nTPM (protected, limit 3); lung: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF669,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000188306,True,compatible,,True,True,True,,0.35,0.203226,0.125,0,80,unavailable,0.4,0.3,0,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,appendix; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRRIQ4,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000188312,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 57.3333% (minimum 65%, Uncertain); adrenal gland: 59.7222% (minimum 75%, Missing); amygdala: 62.3188% (minimum 75%, Missing); basal ganglia: 58.9041% (minimum 75%, Missing); bone marrow: 26.2195% (minimum 75%, Missing); cerebellum: 65.1515% (minimum 75%, Missing); cerebral cortex: 56.5789% (minimum 75%, Missing); colon: 65.1515% (minimum 70%, Missing); duodenum: 61.4286% (minimum 75%, Missing); esophagus: 50.0000% (minimum 70%, Missing); heart muscle: 61.4286% (minimum 75%, Uncertain); hippocampal formation: 59.7222% (minimum 75%, Missing); hypothalamus: 63.2353% (minimum 75%, Missing); kidney: 69.3548% (minimum 75%, Missing); liver: 70.4918% (minimum 75%, Missing); lung: 69.3548% (minimum 75%, Missing); lymph node: 43.8776% (minimum 70%, Uncertain); midbrain: 64.1791% (minimum 75%, Missing); pancreas: 67.1875% (minimum 75%, Missing); parathyroid gland: 65.1515% (minimum 70%, Missing); pituitary gland: 71.6667% (minimum 75%, Missing); rectum: 62.3188% (minimum 70%, Missing); retina: 65.1515% (minimum 75%, Missing); salivary gland: 66.1538% (minimum 70%, Missing); skeletal muscle: 33.0769% (minimum 75%, Missing); skin: 17.0635% (minimum 65%, Missing); small intestine: 70.4918% (minimum 75%, Missing); smooth muscle: 59.7222% (minimum 75%, Missing); spinal cord: 67.1875% (minimum 75%, Missing); spleen: 61.4286% (minimum 65%, Uncertain); thymus: 38.3929% (minimum 65%, Missing); tongue: 50.0000% (minimum 70%, Missing); urinary bladder: 66.1538% (minimum 70%, Missing)",-0.479365,-0.261224,-0.487805,0,3,partial,12.1,5.5,20.9,"skin: 20.9 nTPM (manageable, limit 5); bone marrow: 12.1 nTPM (vital, limit 1); skeletal muscle: 8.7 nTPM (vital, limit 1); thymus: 6.9 nTPM (manageable, limit 5); lymph node: 5.5 nTPM (protected, limit 3); tongue: 4.3 nTPM (protected, limit 3); esophagus: 4.3 nTPM (protected, limit 3); cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); amygdala: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CENPP,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000188321,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.8238% (minimum 75%, Missing); basal ganglia: 74.5882% (minimum 75%, Missing); cerebellum: 70.7589% (minimum 75%, Missing); choroid plexus: 60.6119% (minimum 75%, Missing); colon: 66.3180% (minimum 70%, Missing); heart muscle: 62.4016% (minimum 75%, Missing); hippocampal formation: 74.2389% (minimum 75%, Missing); hypothalamus: 74.2389% (minimum 75%, Missing); kidney: 63.0219% (minimum 75%, Missing); liver: 74.5882% (minimum 75%, Missing); lung: 72.3744% (minimum 75%, Missing); lymph node: 67.0190% (minimum 70%, Missing); parathyroid gland: 59.5865% (minimum 70%, Missing); pituitary gland: 55.7118% (minimum 75%, Missing); retina: 61.5534% (minimum 75%, Missing); small intestine: 68.7636% (minimum 75%, Missing); smooth muscle: 63.1474% (minimum 75%, Missing); spleen: 59.5865% (minimum 65%, Missing); thymus: 59.1418% (minimum 65%, Missing); thyroid gland: 62.4016% (minimum 65%, Missing); urinary bladder: 65.9044% (minimum 70%, Missing)",-0.0585821,-0.104135,-0.192882,0,2,partial,25.2,21.5,21.9,"pituitary gland: 25.2 nTPM (vital, limit 1); thymus: 21.9 nTPM (manageable, limit 5); spleen: 21.5 nTPM (manageable, limit 5); parathyroid gland: 21.5 nTPM (protected, limit 3); choroid plexus: 20.6 nTPM (vital, limit 1); retina: 19.8 nTPM (vital, limit 1); thyroid gland: 19.1 nTPM (manageable, limit 5); heart muscle: 19.1 nTPM (vital, limit 1); kidney: 18.6 nTPM (vital, limit 1); smooth muscle: 18.5 nTPM (vital, limit 1); urinary bladder: 16.4 nTPM (protected, limit 3); colon: 16.1 nTPM (protected, limit 3); lymph node: 15.6 nTPM (protected, limit 3); small intestine: 14.4 nTPM (vital, limit 1); adipose tissue: 14.3 nTPM (manageable, limit 10); adrenal gland: 13.7 nTPM (vital, limit 1); cerebellum: 13.1 nTPM (vital, limit 1); stomach: 12.6 nTPM (protected, limit 3); lung: 12.1 nTPM (vital, limit 1); salivary gland: 12 nTPM (protected, limit 3); hypothalamus: 11 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); liver: 10.8 nTPM (vital, limit 1); basal ganglia: 10.8 nTPM (vital, limit 1); rectum: 10.7 nTPM (protected, limit 3); skin: 10.4 nTPM (manageable, limit 5); pancreas: 10.3 nTPM (vital, limit 1); spinal cord: 10.2 nTPM (vital, limit 1); tongue: 10.2 nTPM (protected, limit 3); midbrain: 10.1 nTPM (vital, limit 1); amygdala: 9.6 nTPM (vital, limit 1); cerebral cortex: 8.3 nTPM (vital, limit 1); esophagus: 7.2 nTPM (protected, limit 3); duodenum: 6.2 nTPM (vital, limit 1); skeletal muscle: 4.6 nTPM (vital, limit 1); bone marrow: 3.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF559,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000188334,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.230835,0,1,partial,7.3,0,0,"retina: 7.3 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BSPH1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000188368,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.317742,0.250226,0.0866534,0,80,unavailable,4.1,1.1,0.7,"basal ganglia: 4.1 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRR19,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000188386,True,compatible,,True,True,True,,0.35,0.3,0.248729,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PPP3R2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000188394,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.0000% (minimum 65%, Missing); amygdala: 69.2308% (minimum 75%, Missing); basal ganglia: 64.2857% (minimum 75%, Missing); cerebral cortex: 36.0000% (minimum 75%, Missing); esophagus: 64.2857% (minimum 70%, Missing); lymph node: 50.0000% (minimum 70%, Missing); rectum: 64.2857% (minimum 70%, Missing); retina: 69.2308% (minimum 75%, Missing); smooth muscle: 50.0000% (minimum 75%, Missing)",-0.15,-0.2,-0.39,0,80,unavailable,1.6,0.9,0.9,"cerebral cortex: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GPR21,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000188408,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEB5,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000188425,True,compatible,,True,True,True,,0.35,0.3,0.222222,0,5,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NANOS2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000188467,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"midbrain: 72.7273% (minimum 75%, Missing); skin: 16.6667% (minimum 65%, Missing)",-0.483333,0.241176,-0.0227273,0,80,unavailable,0.6,0.1,8,"skin: 8 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC24A5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000188558,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); bone marrow: 40.0000% (minimum 75%, Missing); duodenum: 50.0000% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); pancreas: 40.0000% (minimum 75%, Missing); retina: 28.5714% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing); skeletal muscle: 66.6667% (minimum 75%, Missing); skin: 50.0000% (minimum 65%, Missing); small intestine: 66.6667% (minimum 75%, Missing); stomach: 50.0000% (minimum 70%, Missing)",-0.15,-0.2,-0.464286,0,80,unavailable,0.5,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR2G6,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000188585,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 72.4138% (minimum 75%, Missing); lymph node: 65.6250% (minimum 70%, Missing)",0.157692,-0.04375,-0.0258621,0,80,unavailable,0.8,1.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,CLEC20A,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000188687,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 26.5060% (minimum 75%, Missing); parathyroid gland: 56.6176% (minimum 70%, Missing); retina: 27.5000% (minimum 75%, Missing); thyroid gland: 37.2881% (minimum 65%, Uncertain)",-0.277119,-0.133824,-0.48494,0,1,partial,42.7,11.8,25.9,"choroid plexus: 42.7 nTPM (vital, limit 1); retina: 40.6 nTPM (vital, limit 1); thyroid gland: 25.9 nTPM (manageable, limit 5); parathyroid gland: 11.8 nTPM (protected, limit 3); cerebellum: 3.3 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); bone marrow: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC4A5,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000188691,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR56A5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000188738,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"stomach: 67.5325% (minimum 70%, Missing)",0.312963,-0.0246753,0.146552,0,80,unavailable,0.6,2.5,0.2,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FSIP2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential,False,False,False,False,False,unchanged,
ENSG00000188739,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 63.6923% (minimum 65%, Missing); adrenal gland: 67.6471% (minimum 75%, Missing); amygdala: 63.4969% (minimum 75%, Missing); basal ganglia: 66.1342% (minimum 75%, Missing); bone marrow: 37.1634% (minimum 75%, Missing); cerebellum: 73.9286% (minimum 75%, Missing); cerebral cortex: 63.1098% (minimum 75%, Missing); choroid plexus: 58.3099% (minimum 75%, Missing); colon: 63.1098% (minimum 70%, Missing); duodenum: 54.3307% (minimum 75%, Missing); esophagus: 60.7038% (minimum 70%, Missing); heart muscle: 57.9832% (minimum 75%, Missing); hippocampal formation: 65.2997% (minimum 75%, Missing); hypothalamus: 64.0867% (minimum 75%, Missing); kidney: 55.6452% (minimum 75%, Missing); liver: 58.9744% (minimum 75%, Missing); lung: 64.2857% (minimum 75%, Missing); lymph node: 47.8060% (minimum 70%, Missing); midbrain: 61.6071% (minimum 75%, Missing); pancreas: 61.9760% (minimum 75%, Missing); parathyroid gland: 69.6970% (minimum 70%, Missing); pituitary gland: 70.8904% (minimum 75%, Missing); rectum: 60.3499% (minimum 70%, Missing); salivary gland: 51.6209% (minimum 70%, Missing); skeletal muscle: 52.1411% (minimum 75%, Missing); skin: 53.7662% (minimum 65%, Missing); small intestine: 57.3407% (minimum 75%, Missing); smooth muscle: 64.8903% (minimum 75%, Missing); spinal cord: 59.1429% (minimum 75%, Missing); spleen: 62.5378% (minimum 65%, Missing); stomach: 59.8266% (minimum 70%, Missing); thymus: 56.5574% (minimum 65%, Missing); thyroid gland: 57.6602% (minimum 65%, Missing); tongue: 64.4860% (minimum 70%, Missing); urinary bladder: 57.8212% (minimum 70%, Missing)",-0.112338,-0.22194,-0.378366,0,6,partial,35,22.6,17.8,"bone marrow: 35 nTPM (vital, limit 1); lymph node: 22.6 nTPM (protected, limit 3); salivary gland: 19.4 nTPM (protected, limit 3); skeletal muscle: 19 nTPM (vital, limit 1); skin: 17.8 nTPM (manageable, limit 5); duodenum: 17.4 nTPM (vital, limit 1); kidney: 16.5 nTPM (vital, limit 1); thymus: 15.9 nTPM (manageable, limit 5); small intestine: 15.4 nTPM (vital, limit 1); thyroid gland: 15.2 nTPM (manageable, limit 5); urinary bladder: 15.1 nTPM (protected, limit 3); heart muscle: 15 nTPM (vital, limit 1); choroid plexus: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); stomach: 13.9 nTPM (protected, limit 3); rectum: 13.6 nTPM (protected, limit 3); esophagus: 13.4 nTPM (protected, limit 3); midbrain: 12.9 nTPM (vital, limit 1); pancreas: 12.7 nTPM (vital, limit 1); spleen: 12.4 nTPM (manageable, limit 5); cerebral cortex: 12.1 nTPM (vital, limit 1); colon: 12.1 nTPM (protected, limit 3); amygdala: 11.9 nTPM (vital, limit 1); adipose tissue: 11.8 nTPM (manageable, limit 5); hypothalamus: 11.6 nTPM (vital, limit 1); lung: 11.5 nTPM (vital, limit 1); tongue: 11.4 nTPM (protected, limit 3); smooth muscle: 11.2 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); basal ganglia: 10.6 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); parathyroid gland: 9 nTPM (protected, limit 3); pituitary gland: 8.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 1); retina: 6.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: High (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RBM34,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000188782,True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0.2,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CATSPER4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000188784,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.1,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,PLA2G2E,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000188785,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 47.0356% (minimum 65%, Uncertain); adrenal gland: 64.3243% (minimum 75%, Missing); basal ganglia: 73.4568% (minimum 75%, Missing); bone marrow: 31.4815% (minimum 75%, Uncertain); cerebellum: 53.1250% (minimum 75%, Missing); cerebral cortex: 68.3908% (minimum 75%, Missing); choroid plexus: 58.6207% (minimum 75%, Missing); colon: 55.3488% (minimum 70%, Missing); duodenum: 64.3243% (minimum 75%, Missing); esophagus: 60.4061% (minimum 70%, Missing); heart muscle: 52.6549% (minimum 75%, Missing); hippocampal formation: 73.4568% (minimum 75%, Missing); hypothalamus: 74.3750% (minimum 75%, Missing); kidney: 65.3846% (minimum 75%, Missing); liver: 64.3243% (minimum 75%, Missing); lung: 50.6383% (minimum 75%, Missing); lymph node: 33.9031% (minimum 70%, Missing); pancreas: 64.3243% (minimum 75%, Missing); parathyroid gland: 58.9109% (minimum 70%, Missing); pituitary gland: 63.2979% (minimum 75%, Missing); rectum: 60.1010% (minimum 70%, Missing); retina: 49.3776% (minimum 75%, Missing); salivary gland: 63.2979% (minimum 70%, Missing); skeletal muscle: 61.9792% (minimum 75%, Missing); skin: 54.3379% (minimum 65%, Missing); small intestine: 45.5939% (minimum 75%, Missing); smooth muscle: 51.5152% (minimum 75%, Missing); spinal cord: 72.1212% (minimum 75%, Missing); spleen: 39.2739% (minimum 65%, Missing); stomach: 62.9630% (minimum 70%, Missing); thymus: 47.7912% (minimum 65%, Missing); thyroid gland: 51.0730% (minimum 65%, Missing); tongue: 69.1860% (minimum 70%, Missing); urinary bladder: 59.5000% (minimum 70%, Missing)",-0.257261,-0.360969,-0.435185,0,3,partial,25.9,23.2,18.4,"bone marrow: 25.9 nTPM (vital, limit 1); lymph node: 23.2 nTPM (protected, limit 3); spleen: 18.4 nTPM (manageable, limit 5); small intestine: 14.2 nTPM (vital, limit 1); adipose tissue: 13.4 nTPM (manageable, limit 5); thymus: 13 nTPM (manageable, limit 5); retina: 12.2 nTPM (vital, limit 1); lung: 11.6 nTPM (vital, limit 1); thyroid gland: 11.4 nTPM (manageable, limit 5); smooth muscle: 11.2 nTPM (vital, limit 1); heart muscle: 10.7 nTPM (vital, limit 1); cerebellum: 10.5 nTPM (vital, limit 1); skin: 10 nTPM (manageable, limit 5); colon: 9.6 nTPM (protected, limit 3); choroid plexus: 8.4 nTPM (vital, limit 1); parathyroid gland: 8.3 nTPM (protected, limit 3); urinary bladder: 8.1 nTPM (protected, limit 3); rectum: 7.9 nTPM (protected, limit 3); esophagus: 7.8 nTPM (protected, limit 3); skeletal muscle: 7.3 nTPM (vital, limit 1); stomach: 7 nTPM (protected, limit 3); pituitary gland: 6.9 nTPM (vital, limit 1); salivary gland: 6.9 nTPM (protected, limit 3); liver: 6.6 nTPM (vital, limit 1); pancreas: 6.6 nTPM (vital, limit 1); adrenal gland: 6.6 nTPM (vital, limit 1); duodenum: 6.6 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); cerebral cortex: 5.5 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 3); spinal cord: 4.6 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.3 nTPM (vital, limit 1); hypothalamus: 4.1 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / neuronal cells: Low (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF548,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000188800,True,compatible,,True,True,True,,0.35,0.299162,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TMCO2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000188848,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.242157,0.142593,0.142157,0,80,unavailable,1.1,1.7,1.1,"small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BEND4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000188859,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"adipose tissue: 64.7059% (minimum 65%, Missing); colon: 68.7500% (minimum 70%, Missing); heart muscle: 64.7059% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Missing); pancreas: 73.3333% (minimum 75%, Missing); pituitary gland: 68.7500% (minimum 75%, Missing); retina: 57.8947% (minimum 75%, Missing); skeletal muscle: 61.1111% (minimum 75%, Missing); urinary bladder: 61.1111% (minimum 70%, Missing)",-0.00294118,-0.0888889,-0.171053,0,80,unavailable,0.8,0.7,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM78B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000188877,False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,POTEA,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000188909,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"hypothalamus: 18.1818% (minimum 75%, Missing)",0.35,0.3,-0.568182,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BSX,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000188931,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 41.3822% (minimum 75%, Missing)",0.345251,0.299319,-0.336178,0,4,partial,207.8,17.7,25.6,"choroid plexus: 207.8 nTPM (vital, limit 1); skeletal muscle: 81.3 nTPM (vital, limit 6); heart muscle: 38.2 nTPM (vital, limit 6); retina: 31.8 nTPM (vital, limit 1); cerebral cortex: 28 nTPM (vital, limit 6); esophagus: 17.7 nTPM (protected, limit 12); kidney: 16.1 nTPM (vital, limit 6); hypothalamus: 14.9 nTPM (vital, limit 1); lung: 13.5 nTPM (vital, limit 6); adrenal gland: 12.9 nTPM (vital, limit 6); basal ganglia: 12.5 nTPM (vital, limit 1); salivary gland: 12.3 nTPM (protected, limit 12); hippocampal formation: 11.1 nTPM (vital, limit 1); small intestine: 10.8 nTPM (vital, limit 6); duodenum: 10.1 nTPM (vital, limit 6); liver: 9.7 nTPM (vital, limit 6); pancreas: 9.4 nTPM (vital, limit 6); amygdala: 8.5 nTPM (vital, limit 1); midbrain: 8.5 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (ciliary rootlets): Low (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (ciliary rootlets): Low (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP126,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000189023,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEB16,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000189037,True,compatible,,True,True,True,,0.35,0.290476,0.231132,0,80,unavailable,0.2,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DUSP21,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000189052,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"pituitary gland: 74.7748% (minimum 75%, Missing)",0.35,0.3,-0.00225225,0,1,partial,8.4,0.3,0.4,"pituitary gland: 8.4 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CGB5,current_adaptive,True,False,False,False,10.1038/s41467-020-19141-w;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Bradley et al., Nature Communications (2020);Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased",False,False,False,False,False,unchanged,
ENSG00000189064,True,compatible,,True,True,True,,0.35,0.3,0.241435,0,4,partial,0.8,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GAGE2A,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000189090,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 35.8156% (minimum 70%, Missing); salivary gland: 54.0107% (minimum 70%, Missing); skin: 19.4231% (minimum 65%, Missing)",-0.455769,-0.341844,0.113248,0,80,unavailable,1.6,18.1,41.9,"skin: 41.9 nTPM (manageable, limit 5); esophagus: 18.1 nTPM (protected, limit 3); salivary gland: 8.6 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM25G,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000189114,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.8519% (minimum 60%, Approved); adrenal gland: 53.4351% (minimum 75%, Missing); amygdala: 56.0000% (minimum 75%, Missing); basal ganglia: 53.0303% (minimum 75%, Missing); bone marrow: 36.4583% (minimum 75%, Missing); cerebellum: 55.5556% (minimum 75%, Missing); cerebral cortex: 48.6111% (minimum 70%, Approved); choroid plexus: 66.6667% (minimum 75%, Missing); colon: 55.5556% (minimum 70%, Missing); duodenum: 57.3770% (minimum 75%, Missing); esophagus: 53.0303% (minimum 70%, Missing); heart muscle: 58.3333% (minimum 70%, Approved); hippocampal formation: 54.2636% (minimum 75%, Missing); hypothalamus: 56.4516% (minimum 75%, Missing); kidney: 55.5556% (minimum 75%, Missing); liver: 47.9452% (minimum 75%, Missing); lung: 56.9106% (minimum 75%, Missing); lymph node: 48.6111% (minimum 70%, Missing); midbrain: 56.9106% (minimum 75%, Missing); pancreas: 54.2636% (minimum 75%, Missing); parathyroid gland: 60.3448% (minimum 70%, Missing); pituitary gland: 61.9469% (minimum 75%, Missing); rectum: 62.5000% (minimum 70%, Missing); retina: 68.6275% (minimum 75%, Missing); salivary gland: 56.0000% (minimum 70%, Missing); skeletal muscle: 62.5000% (minimum 70%, Approved); skin: 35.3535% (minimum 65%, Missing); small intestine: 51.8519% (minimum 75%, Missing); smooth muscle: 64.2202% (minimum 70%, Approved); spinal cord: 53.4351% (minimum 75%, Missing); spleen: 39.5480% (minimum 65%, Missing); stomach: 48.6111% (minimum 70%, Missing); thymus: 60.3448% (minimum 65%, Missing); thyroid gland: 60.8696% (minimum 65%, Missing); tongue: 68.6275% (minimum 70%, Missing); urinary bladder: 52.2388% (minimum 70%, Missing)",-0.296465,-0.213889,-0.385417,0,5,partial,12.2,7.4,12.8,"skin: 12.8 nTPM (manageable, limit 5); bone marrow: 12.2 nTPM (vital, limit 1); spleen: 10.7 nTPM (manageable, limit 5); liver: 7.6 nTPM (vital, limit 1); lymph node: 7.4 nTPM (protected, limit 3); stomach: 7.4 nTPM (protected, limit 3); cerebral cortex: 7.4 nTPM (vital, limit 2); small intestine: 6.5 nTPM (vital, limit 1); urinary bladder: 6.4 nTPM (protected, limit 3); esophagus: 6.2 nTPM (protected, limit 3); basal ganglia: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); hippocampal formation: 5.9 nTPM (vital, limit 1); kidney: 5.6 nTPM (vital, limit 1); cerebellum: 5.6 nTPM (vital, limit 1); colon: 5.6 nTPM (protected, limit 3); salivary gland: 5.5 nTPM (protected, limit 3); amygdala: 5.5 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); lung: 5.3 nTPM (vital, limit 1); duodenum: 5.2 nTPM (vital, limit 1); heart muscle: 5 nTPM (vital, limit 2); parathyroid gland: 4.6 nTPM (protected, limit 3); pituitary gland: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 2); rectum: 4.2 nTPM (protected, limit 3); smooth muscle: 3.9 nTPM (vital, limit 2); choroid plexus: 3.5 nTPM (vital, limit 1); retina: 3.2 nTPM (vital, limit 1); tongue: 3.2 nTPM (protected, limit 3)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); cerebellum / Purkinje cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Low (Approved); nasopharynx / ciliated cells (ciliary rootlets): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BLOC1S3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000189132,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM47B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000189134,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 72.0183% (minimum 75%, Missing)",0.295783,0.192045,-0.0298165,0,80,unavailable,12.2,3.8,1.8,"retina: 12.2 nTPM (vital, limit 1); skeletal muscle: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); tongue: 3.8 nTPM (protected, limit 3); midbrain: 3.6 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NKAPL,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000189139,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FSCB,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000189144,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 71.7949% (minimum 75%, Missing); bone marrow: 59.5745% (minimum 75%, Missing); cerebral cortex: 68.2927% (minimum 75%, Missing); duodenum: 68.2927% (minimum 75%, Missing); kidney: 70.0000% (minimum 75%, Missing); lung: 68.2927% (minimum 75%, Missing); pancreas: 70.0000% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing); retina: 52.8302% (minimum 75%, Missing); skin: 57.1429% (minimum 65%, Missing); small intestine: 73.6842% (minimum 75%, Missing); spleen: 63.6364% (minimum 65%, Missing); stomach: 59.5745% (minimum 70%, Missing); thyroid gland: 53.8462% (minimum 65%, Missing)",-0.111538,-0.104255,-0.221698,0,3,partial,2.5,1.9,2.4,"retina: 2.5 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: High (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF573,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000189164,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.5385% (minimum 65%, Missing); adrenal gland: 61.5385% (minimum 75%, Missing); amygdala: 69.5652% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); bone marrow: 58.1818% (minimum 75%, Missing); cerebellum: 61.5385% (minimum 75%, Missing); cerebral cortex: 65.3061% (minimum 75%, Missing); colon: 56.1404% (minimum 70%, Missing); esophagus: 69.5652% (minimum 70%, Missing); heart muscle: 59.2593% (minimum 75%, Missing); hippocampal formation: 68.0851% (minimum 75%, Missing); hypothalamus: 65.3061% (minimum 75%, Missing); kidney: 60.3774% (minimum 75%, Missing); liver: 65.3061% (minimum 75%, Missing); lung: 69.5652% (minimum 75%, Missing); lymph node: 61.5385% (minimum 70%, Missing); midbrain: 68.0851% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 55.1724% (minimum 70%, Missing); pituitary gland: 59.2593% (minimum 75%, Missing); rectum: 69.5652% (minimum 70%, Missing); retina: 50.7937% (minimum 75%, Missing); salivary gland: 64.0000% (minimum 70%, Missing); skeletal muscle: 59.2593% (minimum 75%, Missing); small intestine: 65.3061% (minimum 75%, Missing); smooth muscle: 64.0000% (minimum 75%, Missing); spinal cord: 68.0851% (minimum 75%, Missing); spleen: 62.7451% (minimum 65%, Missing); stomach: 65.3061% (minimum 70%, Missing); thymus: 57.1429% (minimum 65%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing); tongue: 52.4590% (minimum 70%, Missing); urinary bladder: 58.1818% (minimum 70%, Missing)",-0.0785714,-0.17541,-0.242063,0,80,unavailable,3.1,2.9,2.4,"retina: 3.1 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); heart muscle: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); adrenal gland: 2 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF527,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000189167,True,compatible,,True,True,True,,0.35,0.175,0.125,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZAR1L,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000189169,False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,9.5,"skin: 9.5 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,KRTAP10-12,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000189186,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DCAF8L2,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000189252,True,compatible,,True,True,True,,0.35,0.3,0.233471,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPANXN3,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000189269,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.283747,0.135185,0.17229,0,80,unavailable,3.8,8.9,3.2,"parathyroid gland: 8.9 nTPM (protected, limit 3); retina: 3.8 nTPM (vital, limit 1); bone marrow: 3.7 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DRICH1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000189298,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 67.1053% (minimum 75%, Missing); cerebral cortex: 69.8630% (minimum 75%, Missing); choroid plexus: 68.0000% (minimum 75%, Missing); colon: 60.7143% (minimum 70%, Missing); duodenum: 70.8333% (minimum 75%, Missing); esophagus: 68.9189% (minimum 70%, Missing); heart muscle: 68.9189% (minimum 75%, Missing); kidney: 61.4458% (minimum 75%, Missing); liver: 65.3846% (minimum 75%, Missing); lung: 62.9630% (minimum 75%, Missing); lymph node: 63.7500% (minimum 70%, Missing); pancreas: 69.8630% (minimum 75%, Missing); parathyroid gland: 52.5773% (minimum 70%, Missing); pituitary gland: 66.2338% (minimum 75%, Missing); rectum: 57.9545% (minimum 70%, Missing); retina: 57.9545% (minimum 75%, Missing); skeletal muscle: 68.0000% (minimum 75%, Missing); skin: 57.9545% (minimum 65%, Missing); small intestine: 68.9189% (minimum 75%, Missing); smooth muscle: 53.1250% (minimum 75%, Missing); spleen: 60.7143% (minimum 65%, Missing); stomach: 56.0440% (minimum 70%, Missing); thymus: 54.8387% (minimum 65%, Missing); thyroid gland: 54.8387% (minimum 65%, Missing); tongue: 68.0000% (minimum 70%, Missing); urinary bladder: 65.3846% (minimum 70%, Missing)",-0.101613,-0.174227,-0.21875,0,3,partial,4.5,4.6,4.2,"parathyroid gland: 4.6 nTPM (protected, limit 3); smooth muscle: 4.5 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 3); retina: 3.7 nTPM (vital, limit 1); rectum: 3.7 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); kidney: 3.2 nTPM (vital, limit 1); lung: 3 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZKSCAN3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000189299,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FOXR2,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000189326,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPANXN4,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000189357,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA31D4,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000189362,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 64.4444% (minimum 75%, Missing); bone marrow: 60.4167% (minimum 75%, Missing); cerebellum: 55.7692% (minimum 75%, Missing); cerebral cortex: 70.7317% (minimum 75%, Missing); colon: 69.0476% (minimum 70%, Missing); esophagus: 65.9091% (minimum 70%, Missing); hippocampal formation: 72.5000% (minimum 75%, Missing); kidney: 69.0476% (minimum 75%, Missing); liver: 63.0435% (minimum 75%, Missing); lung: 64.4444% (minimum 75%, Missing); lymph node: 44.6154% (minimum 70%, Missing); midbrain: 70.7317% (minimum 75%, Missing); pancreas: 72.5000% (minimum 75%, Missing); pituitary gland: 70.7317% (minimum 75%, Missing); retina: 70.7317% (minimum 75%, Missing); salivary gland: 59.1837% (minimum 70%, Missing); skin: 59.1837% (minimum 65%, Missing); small intestine: 64.4444% (minimum 75%, Missing); smooth muscle: 72.5000% (minimum 75%, Missing); spinal cord: 72.5000% (minimum 75%, Missing); spleen: 55.7692% (minimum 65%, Missing); stomach: 61.7021% (minimum 70%, Missing); thymus: 39.1892% (minimum 65%, Missing); thyroid gland: 60.4167% (minimum 65%, Missing)",-0.258108,-0.253846,-0.192308,0,80,unavailable,2.3,3.6,4.5,"lymph node: 3.6 nTPM (protected, limit 3); cerebellum: 2.3 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1); midbrain: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NEMP2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000189375,True,compatible,,True,True,True,,0.340783,0.29537,0.240783,0,80,unavailable,0.2,0.1,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TBC1D28,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000189401,True,compatible,,True,True,True,,0.35,0.3,0.208333,0,6,partial,0.7,0.1,0.3,,,51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OTUD6A,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding,False,True,True,True,True,gained,selectivity_revised
ENSG00000196074,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.280958,0.17631,0.11722,0,80,unavailable,6.4,5.9,3.1,"pancreas: 6.4 nTPM (vital, limit 1); stomach: 5.9 nTPM (protected, limit 3); salivary gland: 4.3 nTPM (protected, limit 3); kidney: 4.2 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SYCP2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000196109,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"heart muscle: 74.0000% (minimum 75%, Missing); kidney: 71.1538% (minimum 75%, Missing); parathyroid gland: 50.6849% (minimum 70%, Missing); thyroid gland: 53.6232% (minimum 65%, Missing)",-0.113768,-0.193151,-0.0384615,0,80,unavailable,1.5,3.6,3.2,"parathyroid gland: 3.6 nTPM (protected, limit 3); kidney: 1.5 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF676,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000196119,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"bone marrow: 25.0000% (minimum 75%, Missing); cerebral cortex: 75.0000% (minimum 75%, Missing); duodenum: 75.0000% (minimum 75%, Missing); heart muscle: 75.0000% (minimum 75%, Missing); liver: 27.2727% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); pancreas: 60.0000% (minimum 75%, Missing); parathyroid gland: 60.0000% (minimum 70%, Missing); retina: 37.5000% (minimum 75%, Missing); salivary gland: 60.0000% (minimum 70%, Missing); skin: 33.3333% (minimum 65%, Missing); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 75.0000% (minimum 75%, Missing); spleen: 60.0000% (minimum 65%, Missing)",-0.316667,-0.1,-0.5,0,80,unavailable,0.9,0.2,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR8A1,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000196172,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 75.0000% (minimum 75%, Missing); cerebellum: 54.5455% (minimum 75%, Missing); cerebral cortex: 51.0638% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); duodenum: 72.7273% (minimum 75%, Missing); esophagus: 55.8140% (minimum 70%, Missing); hypothalamus: 70.5882% (minimum 75%, Missing); lung: 72.7273% (minimum 75%, Missing); lymph node: 47.0588% (minimum 70%, Missing); pancreas: 57.1429% (minimum 75%, Missing); rectum: 57.1429% (minimum 70%, Missing); retina: 72.7273% (minimum 75%, Missing); skin: 53.3333% (minimum 65%, Missing); smooth muscle: 75.0000% (minimum 75%, Missing); spinal cord: 75.0000% (minimum 75%, Missing); spleen: 57.1429% (minimum 65%, Missing); thymus: 38.7097% (minimum 65%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing); urinary bladder: 61.5385% (minimum 70%, Missing)",-0.262903,-0.229412,-0.239362,0,80,unavailable,2.3,2.7,3.8,"cerebral cortex: 2.3 nTPM (vital, limit 1); cerebellum: 2 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF681,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000196184,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR10J1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000196233,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 59.5506% (minimum 65%, Missing); adrenal gland: 63.8554% (minimum 75%, Missing); amygdala: 64.6341% (minimum 75%, Missing); basal ganglia: 64.6341% (minimum 75%, Missing); bone marrow: 17.3770% (minimum 75%, Missing); cerebellum: 45.2991% (minimum 75%, Missing); cerebral cortex: 58.8889% (minimum 75%, Missing); colon: 38.6861% (minimum 70%, Missing); duodenum: 32.7160% (minimum 75%, Missing); esophagus: 43.8017% (minimum 70%, Missing); heart muscle: 59.5506% (minimum 75%, Missing); hippocampal formation: 60.9195% (minimum 75%, Missing); hypothalamus: 62.3529% (minimum 75%, Missing); kidney: 50.9615% (minimum 75%, Missing); liver: 48.1818% (minimum 75%, Missing); lung: 53.0000% (minimum 75%, Missing); lymph node: 46.4912% (minimum 70%, Missing); midbrain: 60.9195% (minimum 75%, Missing); pancreas: 40.1515% (minimum 75%, Missing); parathyroid gland: 55.7895% (minimum 70%, Missing); pituitary gland: 50.9615% (minimum 75%, Missing); rectum: 38.9706% (minimum 70%, Missing); retina: 25.7282% (minimum 75%, Missing); salivary gland: 49.5327% (minimum 70%, Missing); skeletal muscle: 37.3239% (minimum 75%, Missing); skin: 56.9892% (minimum 65%, Missing); small intestine: 33.7580% (minimum 75%, Missing); smooth muscle: 62.3529% (minimum 75%, Missing); spinal cord: 51.4563% (minimum 75%, Missing); spleen: 49.5327% (minimum 65%, Missing); stomach: 39.5522% (minimum 70%, Missing); thymus: 47.7477% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); tongue: 51.9608% (minimum 70%, Missing); urinary bladder: 44.9153% (minimum 70%, Missing)",-0.172523,-0.313139,-0.57623,0,2,partial,25.2,8.4,5.8,"bone marrow: 25.2 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); duodenum: 10.9 nTPM (vital, limit 1); small intestine: 10.4 nTPM (vital, limit 1); skeletal muscle: 8.9 nTPM (vital, limit 1); colon: 8.4 nTPM (protected, limit 3); rectum: 8.3 nTPM (protected, limit 3); stomach: 8.1 nTPM (protected, limit 3); pancreas: 7.9 nTPM (vital, limit 1); esophagus: 6.8 nTPM (protected, limit 3); urinary bladder: 6.5 nTPM (protected, limit 3); cerebellum: 6.4 nTPM (vital, limit 1); lymph node: 6.1 nTPM (protected, limit 3); thymus: 5.8 nTPM (manageable, limit 5); liver: 5.7 nTPM (vital, limit 1); spleen: 5.4 nTPM (manageable, limit 5); salivary gland: 5.4 nTPM (protected, limit 3); thyroid gland: 5.3 nTPM (manageable, limit 5); pituitary gland: 5.1 nTPM (vital, limit 1); kidney: 5.1 nTPM (vital, limit 1); spinal cord: 5 nTPM (vital, limit 1); tongue: 4.9 nTPM (protected, limit 3); lung: 4.7 nTPM (vital, limit 1); parathyroid gland: 4.2 nTPM (protected, limit 3); cerebral cortex: 3.7 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.4 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); basal ganglia: 2.9 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 1 / peripheral nerve: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LCOR,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000196242,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 63.6364% (minimum 75%, Missing)",0.225,0.3,-0.113636,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR2C3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000196335,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.346795,0.29361,0.232622,0,4,partial,1.3,0.4,0.2,"basal ganglia: 1.1 nTPM (vital, limit 1)",stomach 1 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,STK31,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000196341,True,compatible,,True,True,True,,0.207143,0.3,0.107143,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR8D1,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000196350,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF729,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000196357,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.5275% (minimum 75%, Missing); amygdala: 68.0412% (minimum 75%, Missing); basal ganglia: 67.3469% (minimum 75%, Missing); bone marrow: 64.7059% (minimum 75%, Missing); cerebellum: 70.9677% (minimum 75%, Missing); cerebral cortex: 65.3465% (minimum 75%, Missing); choroid plexus: 64.0777% (minimum 75%, Missing); heart muscle: 74.1573% (minimum 75%, Missing); hippocampal formation: 67.3469% (minimum 75%, Missing); hypothalamus: 68.0412% (minimum 75%, Missing); kidney: 73.3333% (minimum 75%, Missing); liver: 69.4737% (minimum 75%, Missing); midbrain: 66.0000% (minimum 75%, Missing); pancreas: 73.3333% (minimum 75%, Missing); pituitary gland: 71.7391% (minimum 75%, Missing); retina: 66.0000% (minimum 75%, Missing); salivary gland: 64.7059% (minimum 70%, Missing); skeletal muscle: 62.2642% (minimum 75%, Missing); smooth muscle: 70.2128% (minimum 75%, Missing); spinal cord: 61.1111% (minimum 75%, Missing); stomach: 69.4737% (minimum 70%, Missing); tongue: 60.0000% (minimum 70%, Missing)",0.0375,-0.1,-0.138889,0,80,unavailable,4.2,4.4,3,"tongue: 4.4 nTPM (protected, limit 3); spinal cord: 4.2 nTPM (vital, limit 1); skeletal muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.5 nTPM (vital, limit 1); midbrain: 3.4 nTPM (vital, limit 1); retina: 3.4 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); liver: 2.9 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF565,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000196388,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.207671,0.148263,0.0669014,0,80,unavailable,10.4,8.3,7.7,"duodenum: 10.4 nTPM (vital, limit 1); skeletal muscle: 10.4 nTPM (vital, limit 1); lymph node: 8.3 nTPM (protected, limit 3); thyroid gland: 7.7 nTPM (manageable, limit 5); small intestine: 7.6 nTPM (vital, limit 1); skin: 7.6 nTPM (manageable, limit 5); spleen: 7.1 nTPM (manageable, limit 5); cerebral cortex: 6.9 nTPM (vital, limit 1); heart muscle: 6.2 nTPM (vital, limit 1); salivary gland: 5.5 nTPM (protected, limit 3); esophagus: 4.9 nTPM (protected, limit 3); stomach: 4.8 nTPM (protected, limit 3); tongue: 4.6 nTPM (protected, limit 3); lung: 4.4 nTPM (vital, limit 1); retina: 4.3 nTPM (vital, limit 1); hippocampal formation: 4 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); spinal cord: 3.7 nTPM (vital, limit 1); liver: 3.7 nTPM (vital, limit 1); adrenal gland: 3.6 nTPM (vital, limit 1); choroid plexus: 3.3 nTPM (vital, limit 1); midbrain: 3.3 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); basal ganglia: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,INCA1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000196391,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 67.9012% (minimum 75%, Missing); amygdala: 71.4286% (minimum 75%, Missing); basal ganglia: 61.1111% (minimum 75%, Missing); cerebellum: 51.8868% (minimum 75%, Missing); cerebral cortex: 54.4554% (minimum 75%, Missing); colon: 55.5556% (minimum 70%, Missing); duodenum: 70.5128% (minimum 75%, Missing); heart muscle: 67.0732% (minimum 75%, Missing); hippocampal formation: 73.3333% (minimum 75%, Missing); hypothalamus: 64.7059% (minimum 75%, Missing); midbrain: 71.4286% (minimum 75%, Missing); pancreas: 59.1398% (minimum 75%, Missing); parathyroid gland: 64.7059% (minimum 70%, Missing); pituitary gland: 65.4762% (minimum 75%, Missing); rectum: 44.7154% (minimum 70%, Missing); retina: 57.2917% (minimum 75%, Missing); salivary gland: 59.1398% (minimum 70%, Missing); skeletal muscle: 48.2456% (minimum 75%, Missing); skin: 64.7059% (minimum 65%, Missing); small intestine: 73.3333% (minimum 75%, Missing); stomach: 67.9012% (minimum 70%, Missing); tongue: 44.3548% (minimum 70%, Missing)",-0.00294118,-0.256452,-0.267544,0,80,unavailable,5.9,6.9,3,"tongue: 6.9 nTPM (protected, limit 3); rectum: 6.8 nTPM (protected, limit 3); skeletal muscle: 5.9 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); cerebral cortex: 4.6 nTPM (vital, limit 1); colon: 4.4 nTPM (protected, limit 3); retina: 4.1 nTPM (vital, limit 1); pancreas: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 3); basal ganglia: 3.5 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); adrenal gland: 2.6 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF774,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000196406,True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPANXD,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000196417,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 68.1034% (minimum 75%, Missing); bone marrow: 65.8333% (minimum 75%, Missing); duodenum: 72.4771% (minimum 75%, Missing); kidney: 74.5283% (minimum 75%, Missing); lung: 72.4771% (minimum 75%, Missing); lymph node: 67.5214% (minimum 70%, Missing); pancreas: 64.2276% (minimum 75%, Missing); parathyroid gland: 48.1707% (minimum 70%, Missing); rectum: 68.6957% (minimum 70%, Missing); small intestine: 74.5283% (minimum 75%, Missing)",0.00289256,-0.218293,-0.107724,0,80,unavailable,4.4,8.5,4.2,"parathyroid gland: 8.5 nTPM (protected, limit 3); pancreas: 4.4 nTPM (vital, limit 1); bone marrow: 4.1 nTPM (vital, limit 1); lymph node: 3.8 nTPM (protected, limit 3); adrenal gland: 3.7 nTPM (vital, limit 1); rectum: 3.6 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); lung: 3 nTPM (vital, limit 1); duodenum: 3 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF765,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000196418,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 62.7119% (minimum 65%, Missing); adrenal gland: 66.0714% (minimum 75%, Missing); bone marrow: 45.1220% (minimum 75%, Missing); cerebellum: 68.5185% (minimum 75%, Missing); cerebral cortex: 69.8113% (minimum 75%, Missing); colon: 38.1443% (minimum 70%, Missing); duodenum: 41.1111% (minimum 75%, Missing); esophagus: 68.5185% (minimum 70%, Missing); heart muscle: 68.5185% (minimum 75%, Missing); hippocampal formation: 72.5490% (minimum 75%, Missing); hypothalamus: 69.8113% (minimum 75%, Missing); kidney: 48.6842% (minimum 75%, Missing); liver: 57.8125% (minimum 75%, Missing); lung: 52.1127% (minimum 75%, Missing); lymph node: 42.0455% (minimum 70%, Missing); midbrain: 69.8113% (minimum 75%, Missing); pancreas: 52.8571% (minimum 75%, Missing); rectum: 40.2174% (minimum 70%, Missing); retina: 54.4118% (minimum 75%, Missing); salivary gland: 63.7931% (minimum 70%, Missing); skeletal muscle: 71.1538% (minimum 75%, Missing); skin: 55.2239% (minimum 65%, Missing); small intestine: 41.5730% (minimum 75%, Missing); smooth muscle: 56.0606% (minimum 75%, Missing); spinal cord: 66.0714% (minimum 75%, Missing); spleen: 44.0476% (minimum 65%, Missing); stomach: 50.0000% (minimum 70%, Missing); thymus: 38.5417% (minimum 65%, Missing); thyroid gland: 56.0606% (minimum 65%, Missing); urinary bladder: 57.8125% (minimum 70%, Missing)",-0.264583,-0.318557,-0.338889,0,80,unavailable,5.3,6,5.9,"colon: 6 nTPM (protected, limit 3); thymus: 5.9 nTPM (manageable, limit 5); rectum: 5.5 nTPM (protected, limit 3); duodenum: 5.3 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); lymph node: 5.1 nTPM (protected, limit 3); bone marrow: 4.5 nTPM (vital, limit 1); kidney: 3.9 nTPM (vital, limit 1); stomach: 3.7 nTPM (protected, limit 3); lung: 3.4 nTPM (vital, limit 1); pancreas: 3.3 nTPM (vital, limit 1); retina: 3.1 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF124,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000196427,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.305556,0.234783,0.0462963,0,1,partial,1.1,0.3,0.2,"small intestine: 1.1 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NBPF4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000196431,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.283333,0.3,0.183333,0,0,routine_complete,0.2,0.1,0.2,,eye / lens fiber cells: High (Supported),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,appendix; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CRYBA4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000196437,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.6027% (minimum 75%, Missing); basal ganglia: 74.1259% (minimum 75%, Missing); bone marrow: 70.1987% (minimum 75%, Missing); cerebellum: 65.8385% (minimum 75%, Missing); cerebral cortex: 69.2810% (minimum 75%, Missing); heart muscle: 72.1088% (minimum 75%, Missing); hypothalamus: 70.6667% (minimum 75%, Missing); retina: 44.3515% (minimum 75%, Missing); skeletal muscle: 71.6216% (minimum 75%, Missing); spinal cord: 74.6479% (minimum 75%, Missing)",0.0125,0.00198675,-0.306485,0,80,unavailable,13.3,4.5,5.4,"retina: 13.3 nTPM (vital, limit 1); cerebellum: 5.5 nTPM (vital, limit 1); thyroid gland: 5.4 nTPM (manageable, limit 5); cerebral cortex: 4.7 nTPM (vital, limit 1); tongue: 4.5 nTPM (protected, limit 3); bone marrow: 4.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 3); skeletal muscle: 4.2 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); lymph node: 3.9 nTPM (protected, limit 3); basal ganglia: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); kidney: 3.4 nTPM (vital, limit 1); smooth muscle: 3.3 nTPM (vital, limit 1); liver: 3.2 nTPM (vital, limit 1); pituitary gland: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.1 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF569,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000196460,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.7059% (minimum 65%, Missing); bone marrow: 22.9167% (minimum 75%, Missing); thymus: 61.1111% (minimum 65%, Missing)",-0.0388889,0.0857143,-0.520833,0,80,unavailable,3.7,0.3,0.7,"bone marrow: 3.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RFX8,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000196466,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.1622% (minimum 65%, Missing); adrenal gland: 62.1622% (minimum 75%, Missing); amygdala: 73.0159% (minimum 75%, Missing); basal ganglia: 71.8750% (minimum 75%, Missing); cerebellum: 70.7692% (minimum 75%, Missing); colon: 64.7887% (minimum 70%, Missing); duodenum: 68.6567% (minimum 75%, Missing); heart muscle: 69.6970% (minimum 75%, Missing); hippocampal formation: 70.7692% (minimum 75%, Missing); hypothalamus: 73.0159% (minimum 75%, Missing); kidney: 58.2278% (minimum 75%, Missing); liver: 55.4217% (minimum 75%, Missing); lung: 62.1622% (minimum 75%, Missing); lymph node: 64.7887% (minimum 70%, Missing); midbrain: 70.7692% (minimum 75%, Missing); pancreas: 68.6567% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing); rectum: 64.7887% (minimum 70%, Missing); salivary gland: 68.6567% (minimum 70%, Missing); skeletal muscle: 71.8750% (minimum 75%, Missing); small intestine: 65.7143% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 70.7692% (minimum 75%, Missing); spleen: 61.3333% (minimum 65%, Missing); thymus: 59.7403% (minimum 65%, Missing); tongue: 67.6471% (minimum 70%, Missing); urinary bladder: 63.8889% (minimum 70%, Missing)",-0.0525974,-0.0611111,-0.195783,0,3,partial,3.7,2.6,3.1,"liver: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); small intestine: 2.4 nTPM (vital, limit 1); smooth muscle: 2.3 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF799,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000196470,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 63.5171% (minimum 75%, Missing); liver: 68.7500% (minimum 75%, Missing); lung: 73.8931% (minimum 75%, Missing); retina: 72.3468% (minimum 75%, Missing); skeletal muscle: 69.9422% (minimum 75%, Missing)",0.0326516,0.0446154,-0.114829,0,4,partial,27.8,16.6,22.5,"bone marrow: 27.8 nTPM (vital, limit 1); adipose tissue: 22.5 nTPM (manageable, limit 5); liver: 22 nTPM (vital, limit 1); skin: 21.6 nTPM (manageable, limit 5); skeletal muscle: 20.8 nTPM (vital, limit 1); retina: 18.5 nTPM (vital, limit 1); lung: 17.1 nTPM (vital, limit 1); thyroid gland: 17 nTPM (manageable, limit 5); tongue: 16.6 nTPM (protected, limit 3); small intestine: 15.8 nTPM (vital, limit 1); salivary gland: 15.6 nTPM (protected, limit 3); colon: 15.5 nTPM (protected, limit 3); duodenum: 15.5 nTPM (vital, limit 1); cerebral cortex: 15.3 nTPM (vital, limit 1); stomach: 15.3 nTPM (protected, limit 3); spinal cord: 14.6 nTPM (vital, limit 1); heart muscle: 14.4 nTPM (vital, limit 1); cerebellum: 14.3 nTPM (vital, limit 1); parathyroid gland: 14.1 nTPM (protected, limit 3); kidney: 14.1 nTPM (vital, limit 1); rectum: 14.1 nTPM (protected, limit 3); hippocampal formation: 14.1 nTPM (vital, limit 1); smooth muscle: 14 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); urinary bladder: 13.7 nTPM (protected, limit 3); pancreas: 13.7 nTPM (vital, limit 1); adrenal gland: 13.7 nTPM (vital, limit 1); lymph node: 13.6 nTPM (protected, limit 3); esophagus: 13.6 nTPM (protected, limit 3); hypothalamus: 13.3 nTPM (vital, limit 1); midbrain: 13.2 nTPM (vital, limit 1); spleen: 13.1 nTPM (manageable, limit 5); amygdala: 13.1 nTPM (vital, limit 1); basal ganglia: 12.4 nTPM (vital, limit 1); pituitary gland: 10.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Enhanced); adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: High (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: High (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: High (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: High (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / collecting ducts: Low (Enhanced); kidney / distal tubules: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / alveolar cells type II: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SIAH1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000196475,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GK2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000196505,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.3333% (minimum 65%, Missing); adrenal gland: 66.6667% (minimum 75%, Missing); bone marrow: 36.8000% (minimum 75%, Missing); cerebral cortex: 74.1935% (minimum 75%, Missing); choroid plexus: 69.6970% (minimum 75%, Missing); colon: 56.0976% (minimum 70%, Missing); duodenum: 54.1176% (minimum 75%, Missing); esophagus: 60.5263% (minimum 70%, Missing); heart muscle: 65.7143% (minimum 75%, Missing); kidney: 50.0000% (minimum 75%, Missing); liver: 48.4211% (minimum 70%, Approved); lung: 58.2278% (minimum 75%, Missing); lymph node: 56.7901% (minimum 65%, Approved); pancreas: 51.6854% (minimum 75%, Missing); parathyroid gland: 49.4624% (minimum 65%, Approved); pituitary gland: 66.6667% (minimum 75%, Missing); rectum: 51.6854% (minimum 70%, Missing); retina: 62.1622% (minimum 75%, Missing); salivary gland: 61.3333% (minimum 70%, Missing); skin: 62.1622% (minimum 65%, Missing); small intestine: 50.5495% (minimum 75%, Missing); smooth muscle: 62.1622% (minimum 70%, Approved); spleen: 52.8736% (minimum 60%, Approved); stomach: 52.2727% (minimum 70%, Missing); thymus: 54.1176% (minimum 65%, Missing); thyroid gland: 50.5495% (minimum 65%, Missing); tongue: 69.6970% (minimum 70%, Missing); urinary bladder: 51.6854% (minimum 70%, Missing)",-0.144505,-0.183146,-0.382,0,4,partial,7.9,4.7,4.5,"bone marrow: 7.9 nTPM (vital, limit 1); liver: 4.9 nTPM (vital, limit 2); parathyroid gland: 4.7 nTPM (protected, limit 4); kidney: 4.6 nTPM (vital, limit 1); small intestine: 4.5 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 3); pancreas: 4.3 nTPM (vital, limit 1); urinary bladder: 4.3 nTPM (protected, limit 3); stomach: 4.2 nTPM (protected, limit 3); duodenum: 3.9 nTPM (vital, limit 1); colon: 3.6 nTPM (protected, limit 3); lung: 3.3 nTPM (vital, limit 1); smooth muscle: 2.8 nTPM (vital, limit 2); retina: 2.8 nTPM (vital, limit 1); heart muscle: 2.4 nTPM (vital, limit 1); pituitary gland: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells type II: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GDAP2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000196511,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.9451% (minimum 65%, Missing); adrenal gland: 60.2410% (minimum 75%, Missing); amygdala: 69.4444% (minimum 75%, Missing); basal ganglia: 71.4286% (minimum 75%, Missing); bone marrow: 64.9351% (minimum 75%, Missing); cerebellum: 74.6269% (minimum 75%, Missing); cerebral cortex: 60.2410% (minimum 75%, Missing); choroid plexus: 51.5464% (minimum 75%, Missing); colon: 45.0450% (minimum 70%, Missing); duodenum: 26.8817% (minimum 75%, Missing); heart muscle: 61.7284% (minimum 75%, Missing); hippocampal formation: 71.4286% (minimum 75%, Missing); hypothalamus: 64.9351% (minimum 75%, Missing); kidney: 56.8182% (minimum 75%, Missing); liver: 54.3478% (minimum 75%, Missing); lung: 50.5051% (minimum 75%, Missing); lymph node: 47.1698% (minimum 70%, Missing); midbrain: 69.4444% (minimum 75%, Missing); pancreas: 72.4638% (minimum 75%, Missing); rectum: 46.2963% (minimum 70%, Missing); retina: 69.4444% (minimum 75%, Missing); salivary gland: 58.8235% (minimum 70%, Missing); small intestine: 40.9836% (minimum 75%, Missing); smooth muscle: 59.5238% (minimum 75%, Missing); spinal cord: 67.5676% (minimum 75%, Missing); spleen: 39.3701% (minimum 65%, Missing); thymus: 64.9351% (minimum 65%, Missing); thyroid gland: 62.5000% (minimum 65%, Missing); tongue: 64.1026% (minimum 70%, Missing); urinary bladder: 56.1798% (minimum 70%, Missing)",-0.256299,-0.24955,-0.481183,0,2,partial,13.6,6.1,7.7,"duodenum: 13.6 nTPM (vital, limit 1); spleen: 7.7 nTPM (manageable, limit 5); small intestine: 7.2 nTPM (vital, limit 1); colon: 6.1 nTPM (protected, limit 3); rectum: 5.8 nTPM (protected, limit 3); lymph node: 5.6 nTPM (protected, limit 3); lung: 4.9 nTPM (vital, limit 1); choroid plexus: 4.7 nTPM (vital, limit 1); liver: 4.2 nTPM (vital, limit 1); urinary bladder: 3.9 nTPM (protected, limit 3); kidney: 3.8 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 3); smooth muscle: 3.4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); spinal cord: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.6 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TPK1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000196550,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.8889% (minimum 65%, Missing); adrenal gland: 69.0000% (minimum 75%, Missing); bone marrow: 44.8052% (minimum 75%, Missing); cerebellum: 55.6452% (minimum 75%, Missing); duodenum: 70.4082% (minimum 75%, Missing); hippocampal formation: 74.1935% (minimum 75%, Missing); lung: 72.6316% (minimum 75%, Missing); lymph node: 39.2045% (minimum 70%, Missing); midbrain: 72.6316% (minimum 75%, Missing); skin: 53.9062% (minimum 65%, Missing); small intestine: 70.4082% (minimum 75%, Missing); spinal cord: 71.8750% (minimum 75%, Missing); spleen: 53.0769% (minimum 65%, Missing); thymus: 45.0980% (minimum 65%, Missing)",-0.19902,-0.307955,-0.301948,0,80,unavailable,8.5,10.7,8.4,"lymph node: 10.7 nTPM (protected, limit 3); bone marrow: 8.5 nTPM (vital, limit 1); thymus: 8.4 nTPM (manageable, limit 5); spleen: 6.1 nTPM (manageable, limit 5); skin: 5.9 nTPM (manageable, limit 5); cerebellum: 5.5 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); midbrain: 2.6 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM72A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000196553,True,compatible,,True,True,True,,0.35,0.3,0.231481,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC196,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Gong 2021 · reproductive coding;Loriot 2025 · preferential,False,True,True,True,True,gained,selectivity_revised
ENSG00000196565,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.349769,0.29995,0.242322,0,2,partial,77,3.7,26.7,"bone marrow: 77 nTPM (vital, limit 1); spleen: 26.7 nTPM (manageable, limit 10); lung: 15.9 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); pancreas: 9 nTPM (vital, limit 2); midbrain: 8.1 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 2); liver: 6 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 2); spinal cord: 4.8 nTPM (vital, limit 1); amygdala: 4.7 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 2); skeletal muscle: 4 nTPM (vital, limit 2); basal ganglia: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 2); cerebellum: 2.1 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HBG2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000196570,True,compatible,,True,True,True,,0.35,0.3,0.215251,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PFN3,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000196578,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR5AC2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000196584,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 36.6667% (minimum 75%, Missing); duodenum: 64.7059% (minimum 75%, Missing); heart muscle: 71.7391% (minimum 75%, Missing); lymph node: 51.5625% (minimum 70%, Missing); rectum: 63.4615% (minimum 70%, Missing); retina: 62.2642% (minimum 75%, Missing); skin: 61.1111% (minimum 65%, Missing); small intestine: 67.3469% (minimum 75%, Missing); thymus: 46.4789% (minimum 65%, Missing)",-0.185211,-0.184375,-0.383333,0,80,unavailable,5.7,3.1,3.8,"bone marrow: 5.7 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 3); retina: 2 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,XRCC2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000196597,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 67.4157% (minimum 75%, Missing); cerebral cortex: 68.1818% (minimum 75%, Missing); duodenum: 73.1707% (minimum 75%, Missing); kidney: 69.7674% (minimum 75%, Missing); lymph node: 68.9655% (minimum 70%, Missing); pancreas: 56.6038% (minimum 75%, Missing); parathyroid gland: 65.9341% (minimum 70%, Missing); rectum: 68.1818% (minimum 70%, Missing); retina: 40.0000% (minimum 75%, Missing); skeletal muscle: 73.1707% (minimum 75%, Missing); skin: 60.6061% (minimum 65%, Missing); small intestine: 67.4157% (minimum 75%, Missing); smooth muscle: 73.1707% (minimum 75%, Missing); stomach: 68.9655% (minimum 70%, Missing); thymus: 64.5161% (minimum 65%, Missing); thyroid gland: 64.5161% (minimum 65%, Missing)",-0.0439394,-0.0406593,-0.35,0,2,partial,9,3.1,3.9,"retina: 9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 3); small intestine: 2.9 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.2 nTPM (vital, limit 1); choroid plexus: 1.8 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF782,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000196604,True,compatible,,True,True,True,,0.35,0.3,0.144737,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,POTEF,current_adaptive,True,False,True,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,True,True,True,True,gained,selectivity_revised
ENSG00000196605,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 73.1707% (minimum 75%, Missing); choroid plexus: 72.2892% (minimum 75%, Missing); colon: 69.4981% (minimum 70%, Missing); esophagus: 66.6667% (minimum 70%, Missing); heart muscle: 69.4981% (minimum 75%, Missing); hippocampal formation: 73.1707% (minimum 75%, Missing); lung: 73.1707% (minimum 75%, Missing); midbrain: 69.7674% (minimum 75%, Missing); retina: 72.8745% (minimum 75%, Missing); smooth muscle: 64.0569% (minimum 70%, Approved); spinal cord: 65.6934% (minimum 75%, Missing); urinary bladder: 58.6319% (minimum 70%, Missing)",0.0614625,-0.113681,-0.0930657,0,1,partial,10.1,12.7,7.6,"urinary bladder: 12.7 nTPM (protected, limit 3); smooth muscle: 10.1 nTPM (vital, limit 2); spinal cord: 9.4 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 3); colon: 7.9 nTPM (protected, limit 3); heart muscle: 7.9 nTPM (vital, limit 1); midbrain: 7.8 nTPM (vital, limit 1); lymph node: 7.8 nTPM (protected, limit 4); thymus: 7.3 nTPM (manageable, limit 5); skin: 7.3 nTPM (manageable, limit 5); parathyroid gland: 7 nTPM (protected, limit 4); salivary gland: 6.9 nTPM (protected, limit 3); choroid plexus: 6.9 nTPM (vital, limit 1); rectum: 6.8 nTPM (protected, limit 4); retina: 6.7 nTPM (vital, limit 1); hippocampal formation: 6.6 nTPM (vital, limit 1); lung: 6.6 nTPM (vital, limit 1); amygdala: 6.6 nTPM (vital, limit 1); stomach: 6.3 nTPM (protected, limit 3); adrenal gland: 6.1 nTPM (vital, limit 2); hypothalamus: 5.9 nTPM (vital, limit 1); basal ganglia: 5.5 nTPM (vital, limit 1); pituitary gland: 5.4 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 3); cerebral cortex: 5.2 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); skeletal muscle: 5 nTPM (vital, limit 1); kidney: 4.9 nTPM (vital, limit 1); liver: 4.5 nTPM (vital, limit 2); bone marrow: 4.4 nTPM (vital, limit 1); duodenum: 4.1 nTPM (vital, limit 2); cerebellum: 3.9 nTPM (vital, limit 2); pancreas: 3.7 nTPM (vital, limit 2)",bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF846,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000196632,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341379,0.274576,0.0323129,0,1,partial,3.5,0.9,0.6,"liver: 3.5 nTPM (vital, limit 2); retina: 3.2 nTPM (vital, limit 1); adrenal gland: 2.4 nTPM (vital, limit 2); pituitary gland: 2.4 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,WNK3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000196659,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 71.4286% (minimum 75%, Missing); retina: 66.2252% (minimum 75%, Missing)",0.00865922,0.0575758,-0.0877483,0,8,partial,5.1,4.9,7.9,"retina: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 3); choroid plexus: 4 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); lung: 3.1 nTPM (vital, limit 3); small intestine: 2.8 nTPM (vital, limit 1); duodenum: 2.5 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: High (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IFT70B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000196689,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.4615% (minimum 65%, Missing); adrenal gland: 67.3469% (minimum 75%, Missing); amygdala: 61.4907% (minimum 75%, Missing); basal ganglia: 61.4907% (minimum 75%, Missing); cerebellum: 43.2314% (minimum 75%, Missing); cerebral cortex: 60.7362% (minimum 75%, Missing); colon: 64.2857% (minimum 70%, Missing); duodenum: 58.2353% (minimum 75%, Missing); heart muscle: 57.5581% (minimum 75%, Missing); hippocampal formation: 58.9286% (minimum 75%, Missing); hypothalamus: 61.8750% (minimum 75%, Missing); kidney: 55.6180% (minimum 75%, Missing); liver: 29.2035% (minimum 75%, Missing); midbrain: 58.9286% (minimum 75%, Missing); pancreas: 56.5714% (minimum 75%, Missing); pituitary gland: 63.4615% (minimum 75%, Missing); retina: 44.1964% (minimum 75%, Missing); skeletal muscle: 61.1111% (minimum 75%, Missing); small intestine: 54.0984% (minimum 75%, Missing); spinal cord: 59.6386% (minimum 75%, Missing); stomach: 63.4615% (minimum 70%, Missing); urinary bladder: 67.3469% (minimum 70%, Missing)",-0.0153846,-0.0653846,-0.457965,0,80,unavailable,24,5.7,5.7,"liver: 24 nTPM (vital, limit 1); cerebellum: 13 nTPM (vital, limit 1); retina: 12.5 nTPM (vital, limit 1); small intestine: 8.4 nTPM (vital, limit 1); kidney: 7.9 nTPM (vital, limit 1); pancreas: 7.6 nTPM (vital, limit 1); heart muscle: 7.3 nTPM (vital, limit 1); duodenum: 7.1 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); midbrain: 6.9 nTPM (vital, limit 1); spinal cord: 6.7 nTPM (vital, limit 1); cerebral cortex: 6.4 nTPM (vital, limit 1); skeletal muscle: 6.3 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); amygdala: 6.2 nTPM (vital, limit 1); hypothalamus: 6.1 nTPM (vital, limit 1); stomach: 5.7 nTPM (protected, limit 3); pituitary gland: 5.7 nTPM (vital, limit 1); adipose tissue: 5.7 nTPM (manageable, limit 5); colon: 5.5 nTPM (protected, limit 3); skin: 5.3 nTPM (manageable, limit 5); adrenal gland: 4.8 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); salivary gland: 4.2 nTPM (protected, limit 3); esophagus: 3.2 nTPM (protected, limit 3); lung: 3.1 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRPV1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000196712,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 62.8099% (minimum 65%, Uncertain); adrenal gland: 57.7947% (minimum 75%, Missing); amygdala: 61.7886% (minimum 75%, Missing); basal ganglia: 61.2903% (minimum 75%, Missing); cerebellum: 54.8736% (minimum 75%, Missing); cerebral cortex: 44.3149% (minimum 75%, Missing); choroid plexus: 61.5385% (minimum 75%, Missing); colon: 60.5578% (minimum 70%, Missing); duodenum: 65.5172% (minimum 75%, Missing); heart muscle: 54.8736% (minimum 75%, Missing); hippocampal formation: 61.7886% (minimum 75%, Missing); hypothalamus: 62.2951% (minimum 75%, Missing); kidney: 52.5952% (minimum 75%, Missing); liver: 55.8824% (minimum 75%, Missing); lung: 65.2361% (minimum 75%, Missing); lymph node: 61.2903% (minimum 70%, Missing); midbrain: 62.0408% (minimum 75%, Missing); pancreas: 58.4615% (minimum 75%, Missing); parathyroid gland: 45.3731% (minimum 70%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); rectum: 60.0791% (minimum 70%, Missing); retina: 36.8039% (minimum 75%, Missing); salivary gland: 57.3585% (minimum 70%, Missing); skeletal muscle: 62.2951% (minimum 75%, Missing); skin: 58.2375% (minimum 65%, Missing); small intestine: 63.5983% (minimum 75%, Missing); smooth muscle: 61.0442% (minimum 75%, Missing); spinal cord: 58.9147% (minimum 75%, Missing); spleen: 64.1350% (minimum 65%, Missing); stomach: 62.5514% (minimum 70%, Missing); thymus: 47.7987% (minimum 65%, Missing); thyroid gland: 42.9379% (minimum 65%, Missing); tongue: 55.2727% (minimum 70%, Missing); urinary bladder: 56.7164% (minimum 70%, Missing)",-0.220621,-0.246269,-0.381961,0,6,partial,26.1,18.3,20.2,"retina: 26.1 nTPM (vital, limit 1); thyroid gland: 20.2 nTPM (manageable, limit 5); cerebral cortex: 19.1 nTPM (vital, limit 1); parathyroid gland: 18.3 nTPM (protected, limit 3); thymus: 16.6 nTPM (manageable, limit 5); kidney: 13.7 nTPM (vital, limit 1); cerebellum: 12.5 nTPM (vital, limit 1); heart muscle: 12.5 nTPM (vital, limit 1); tongue: 12.3 nTPM (protected, limit 3); liver: 12 nTPM (vital, limit 1); urinary bladder: 11.6 nTPM (protected, limit 3); salivary gland: 11.3 nTPM (protected, limit 3); adrenal gland: 11.1 nTPM (vital, limit 1); skin: 10.9 nTPM (manageable, limit 5); pancreas: 10.8 nTPM (vital, limit 1); spinal cord: 10.6 nTPM (vital, limit 1); rectum: 10.1 nTPM (protected, limit 3); colon: 9.9 nTPM (protected, limit 3); smooth muscle: 9.7 nTPM (vital, limit 1); basal ganglia: 9.6 nTPM (vital, limit 1); lymph node: 9.6 nTPM (protected, limit 3); choroid plexus: 9.5 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); hippocampal formation: 9.4 nTPM (vital, limit 1); midbrain: 9.3 nTPM (vital, limit 1); skeletal muscle: 9.2 nTPM (vital, limit 1); hypothalamus: 9.2 nTPM (vital, limit 1); stomach: 9.1 nTPM (protected, limit 3); adipose tissue: 9 nTPM (manageable, limit 5); small intestine: 8.7 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); lung: 8.1 nTPM (vital, limit 1); duodenum: 8 nTPM (vital, limit 1); pituitary gland: 7.6 nTPM (vital, limit 1); esophagus: 6.4 nTPM (protected, limit 3); bone marrow: 3.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); kidney / cells in tubules: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); skin 1 / keratinocytes: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NF1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000196748,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.349807,0.296923,0.249229,0,3,partial,5,1.6,0.2,"pancreas: 5 nTPM (vital, limit 2)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); colon / glandular cells: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skin 2 / epidermal cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder / glandular cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CLPSL2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000196772,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.25,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR14A16,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000196832,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR11G2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000196834,True,compatible,,True,True,True,,0.319697,0.241176,0.138889,0,80,unavailable,0.4,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,POTEI,current_adaptive,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,True,True,True,True,gained,selectivity_revised
ENSG00000196844,True,compatible,,True,True,True,,0.35,0.3,0.249091,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PATE2,current_adaptive,True,False,True,True,10.1038/ncomms10499,Wang 2016,True,True,True,True,True,unchanged,
ENSG00000196860,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.213636,0,4,partial,0.4,0.5,0.5,,duodenum / glandular cells: Low (Enhanced); small intestine / glandular cells: Low (Enhanced),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TOMM20L,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000196862,True,compatible,,True,True,True,,0.273077,0.223077,0.0326087,0,80,unavailable,1,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RGPD4,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,True,True,True,True,gained,selectivity_revised
ENSG00000196900,True,compatible,,True,True,True,,0.35,0.274249,0.241266,0,80,unavailable,0.2,0.6,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPMIP10,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000196911,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 67.6080% (minimum 75%, Missing)",0.135714,0.0664783,-0.0739203,0,8,partial,19.5,12.4,11.1,"retina: 19.5 nTPM (vital, limit 1); skeletal muscle: 12.7 nTPM (vital, limit 1); tongue: 12.4 nTPM (protected, limit 3); thyroid gland: 11.1 nTPM (manageable, limit 5); cerebral cortex: 10.4 nTPM (vital, limit 1); thymus: 9.6 nTPM (manageable, limit 5); cerebellum: 7.4 nTPM (vital, limit 1); parathyroid gland: 7 nTPM (protected, limit 3); smooth muscle: 6.6 nTPM (vital, limit 6); adrenal gland: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); bone marrow: 4.5 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); heart muscle: 4.4 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 3); salivary gland: 4.2 nTPM (protected, limit 3); stomach: 3.7 nTPM (protected, limit 3); rectum: 3.3 nTPM (protected, limit 3); colon: 3.2 nTPM (protected, limit 3); small intestine: 3.2 nTPM (vital, limit 1); spinal cord: 3.1 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Low (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / distal tubules: Medium (Enhanced); kidney / proximal tubules (cell body): Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 1 / cells in granular layer: Low (Enhanced); skin 1 / endothelial cells: Medium (Enhanced); skin 1 / fibrohistiocytic cells: Medium (Enhanced); skin 2 / cells in granular layer: Low (Enhanced); skin 2 / cells in spinous layer: Low (Enhanced); skin 2 / endothelial cells: Medium (Enhanced); skin 2 / fibrohistiocytic cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in granular layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KPNA5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000196912,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 56.7164% (minimum 65%, Missing); adrenal gland: 73.0769% (minimum 75%, Missing); amygdala: 63.3333% (minimum 75%, Missing); basal ganglia: 60.3175% (minimum 75%, Missing); bone marrow: 33.6283% (minimum 75%, Missing); cerebellum: 29.9213% (minimum 75%, Missing); cerebral cortex: 60.3175% (minimum 75%, Missing); colon: 60.3175% (minimum 70%, Missing); heart muscle: 66.6667% (minimum 75%, Missing); hippocampal formation: 59.3750% (minimum 75%, Missing); hypothalamus: 64.4068% (minimum 75%, Missing); kidney: 71.6981% (minimum 75%, Missing); lung: 64.4068% (minimum 75%, Missing); lymph node: 64.4068% (minimum 70%, Missing); midbrain: 63.3333% (minimum 75%, Missing); pancreas: 48.1013% (minimum 75%, Missing); pituitary gland: 61.2903% (minimum 75%, Missing); rectum: 65.5172% (minimum 70%, Missing); retina: 55.8824% (minimum 75%, Missing); salivary gland: 51.3514% (minimum 70%, Missing); skin: 55.8824% (minimum 65%, Missing); small intestine: 62.2951% (minimum 75%, Missing); spinal cord: 55.8824% (minimum 75%, Missing); spleen: 64.4068% (minimum 65%, Missing); stomach: 63.3333% (minimum 70%, Missing); thyroid gland: 62.2951% (minimum 65%, Missing); urinary bladder: 64.4068% (minimum 70%, Missing)",-0.0911765,-0.186486,-0.450787,0,80,unavailable,8.9,3.6,3,"cerebellum: 8.9 nTPM (vital, limit 1); bone marrow: 7.5 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); salivary gland: 3.6 nTPM (protected, limit 3); spinal cord: 3 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); lung: 2.1 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); kidney: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ANKRD36B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000196946,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 62.1622% (minimum 75%, Missing); smooth muscle: 74.1935% (minimum 75%, Missing)",0.00714286,0.0931034,-0.128378,0,80,unavailable,1.4,0.6,1.2,"cerebral cortex: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF705A,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000197054,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 61.0526% (minimum 65%, Missing); adrenal gland: 65.9091% (minimum 75%, Missing); basal ganglia: 74.3590% (minimum 75%, Missing); cerebellum: 68.2353% (minimum 70%, Approved); choroid plexus: 65.1685% (minimum 75%, Missing); colon: 63.7363% (minimum 70%, Missing); duodenum: 72.5000% (minimum 75%, Missing); heart muscle: 60.4167% (minimum 75%, Missing); hippocampal formation: 73.4177% (minimum 75%, Missing); kidney: 50.4348% (minimum 75%, Missing); liver: 70.7317% (minimum 75%, Missing); lung: 67.4419% (minimum 75%, Missing); lymph node: 62.3656% (minimum 70%, Missing); midbrain: 71.6049% (minimum 75%, Missing); pancreas: 56.8627% (minimum 75%, Missing); parathyroid gland: 55.7692% (minimum 70%, Missing); pituitary gland: 67.4419% (minimum 75%, Missing); rectum: 66.6667% (minimum 70%, Missing); retina: 46.4000% (minimum 75%, Missing); salivary gland: 64.4444% (minimum 70%, Missing); small intestine: 58.0000% (minimum 75%, Missing); smooth muscle: 73.4177% (minimum 75%, Missing); spinal cord: 74.3590% (minimum 75%, Missing); spleen: 52.7273% (minimum 65%, Missing); stomach: 63.0435% (minimum 70%, Missing); thymus: 58.0000% (minimum 65%, Missing); thyroid gland: 55.2381% (minimum 65%, Missing); urinary bladder: 63.0435% (minimum 70%, Missing)",-0.122727,-0.142308,-0.286,0,5,partial,6.7,4.6,5.2,"retina: 6.7 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); spleen: 5.2 nTPM (manageable, limit 5); parathyroid gland: 4.6 nTPM (protected, limit 3); pancreas: 4.4 nTPM (vital, limit 1); small intestine: 4.2 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); lymph node: 3.5 nTPM (protected, limit 3); urinary bladder: 3.4 nTPM (protected, limit 3); stomach: 3.4 nTPM (protected, limit 3); colon: 3.3 nTPM (protected, limit 3); salivary gland: 3.2 nTPM (protected, limit 3); choroid plexus: 3.1 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); lung: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 2); liver: 2.4 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); duodenum: 2.2 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF763,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000197079,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 5.0000% (minimum 50%, Enhanced); salivary gland: 14.2857% (minimum 55%, Enhanced); skin: 0.1773% (minimum 50%, Enhanced)",-0.498227,-0.407143,0.25,0,6,partial,0,0.6,56.3,"skin: 56.3 nTPM (manageable, limit 30)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,hair / cells in cortex/medulla; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KRT35,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000197123,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF679,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000197134,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 38.8060% (minimum 75%, Missing); lymph node: 50.9804% (minimum 70%, Missing); pancreas: 55.3191% (minimum 75%, Missing); spleen: 61.9048% (minimum 65%, Missing); stomach: 65.0000% (minimum 70%, Missing); thymus: 61.9048% (minimum 65%, Missing); thyroid gland: 54.1667% (minimum 65%, Missing)",-0.108333,-0.190196,-0.36194,0,80,unavailable,4.1,2.5,2.2,"bone marrow: 4.1 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF257,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000197140,True,compatible,,True,True,True,,0.35,0.296255,0.217273,0,6,partial,1.7,0.5,0.9,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ADAM32,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,False,gained,selectivity_revised
ENSG00000197153,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"amygdala: 50.0000% (minimum 75%, Missing); bone marrow: 20.0000% (minimum 75%, Missing); liver: 75.0000% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 23.0769% (minimum 70%, Missing); small intestine: 75.0000% (minimum 75%, Missing); spleen: 42.8571% (minimum 65%, Missing); thymus: 21.4286% (minimum 65%, Missing)",-0.435714,-0.469231,-0.55,0,7,partial,1.2,1,1.1,"bone marrow: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / cells in basal layer: High (Approved); skin 1 / cells in granular layer: High (Approved); skin 1 / cells in spinous layer: High (Approved); skin 1 / endothelial cells: High (Approved); skin 1 / fibrohistiocytic cells: High (Approved); skin 1 / langerhans cells: High (Approved); skin 1 / lymphocytes: High (Approved); skin 1 / vascular mural cells: High (Approved); skin 2 / cells in basal layer: High (Approved); skin 2 / cells in granular layer: High (Approved); skin 2 / cells in spinous layer: High (Approved); skin 2 / endothelial cells: High (Approved); skin 2 / fibrohistiocytic cells: High (Approved); skin 2 / langerhans cells: High (Approved); skin 2 / lymphocytes: High (Approved); skin 2 / vascular mural cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / chondrocytes: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 2 / chondrocytes: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: High (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),70,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / fibrohistiocytic cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / vascular mural cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,H3C12,current_adaptive,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000197172,True,compatible,,True,True,True,,0.321831,0.3,0.235714,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEA6,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000197181,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.312069,0.252218,0.0778932,0,80,unavailable,5.8,1.4,1.1,"duodenum: 5.8 nTPM (vital, limit 1); skeletal muscle: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PIWIL2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000197183,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 69.1438% (minimum 75%, Missing); duodenum: 69.7068% (minimum 75%, Missing); hippocampal formation: 74.5645% (minimum 75%, Missing); pituitary gland: 66.4596% (minimum 75%, Missing); retina: 47.1366% (minimum 75%, Missing); small intestine: 68.5897% (minimum 75%, Missing); spinal cord: 67.4016% (minimum 75%, Missing)",0.0853952,0.0205387,-0.278634,0,4,partial,48,16.6,15.4,"retina: 48 nTPM (vital, limit 1); pituitary gland: 21.6 nTPM (vital, limit 1); bone marrow: 20.9 nTPM (vital, limit 6); spinal cord: 20.7 nTPM (vital, limit 1); small intestine: 19.6 nTPM (vital, limit 1); cerebellum: 19.1 nTPM (vital, limit 1); duodenum: 18.6 nTPM (vital, limit 1); colon: 16.6 nTPM (protected, limit 3); thymus: 15.4 nTPM (manageable, limit 5); hippocampal formation: 14.6 nTPM (vital, limit 1); kidney: 14 nTPM (vital, limit 1); rectum: 13.2 nTPM (protected, limit 3); amygdala: 13 nTPM (vital, limit 1); stomach: 13 nTPM (protected, limit 3); lung: 12.7 nTPM (vital, limit 1); spleen: 12.6 nTPM (manageable, limit 5); cerebral cortex: 12.3 nTPM (vital, limit 1); hypothalamus: 12 nTPM (vital, limit 1); midbrain: 12 nTPM (vital, limit 1); pancreas: 10.7 nTPM (vital, limit 1); adipose tissue: 9.9 nTPM (manageable, limit 5); salivary gland: 9.5 nTPM (protected, limit 3); thyroid gland: 9.3 nTPM (manageable, limit 5); urinary bladder: 9.3 nTPM (protected, limit 3); basal ganglia: 9.3 nTPM (vital, limit 1); choroid plexus: 9.1 nTPM (vital, limit 1); adrenal gland: 8.6 nTPM (vital, limit 6); lymph node: 8.1 nTPM (protected, limit 3); liver: 6.7 nTPM (vital, limit 6); smooth muscle: 6.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / cells in granular layer: Low (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endothelial cells: High (Enhanced); colon / glandular cells: High (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 1 / peripheral nerve: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); spleen / cells in red pulp: Medium (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NOL4L,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000197213,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.294444,0.3,0.1,0,1,partial,0.3,0,0.1,,cerebral cortex / neuronal cells: Low (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain),54,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZSCAN5B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000197217,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 63.4868% (minimum 75%, Missing); amygdala: 68.1979% (minimum 75%, Missing); basal ganglia: 68.6833% (minimum 75%, Missing); bone marrow: 38.9899% (minimum 75%, Missing); cerebellum: 54.0616% (minimum 75%, Missing); cerebral cortex: 49.1094% (minimum 75%, Missing); choroid plexus: 66.7820% (minimum 75%, Missing); colon: 50.2604% (minimum 70%, Missing); duodenum: 52.4457% (minimum 75%, Missing); heart muscle: 48.6146% (minimum 65%, Supported); hippocampal formation: 63.6964% (minimum 75%, Missing); hypothalamus: 65.2027% (minimum 75%, Missing); kidney: 62.0579% (minimum 75%, Missing); liver: 59.0214% (minimum 65%, Supported); lung: 50.0000% (minimum 75%, Missing); lymph node: 40.2923% (minimum 70%, Missing); midbrain: 64.3333% (minimum 75%, Missing); pancreas: 48.1297% (minimum 75%, Missing); parathyroid gland: 42.4176% (minimum 70%, Missing); pituitary gland: 52.0216% (minimum 75%, Missing); rectum: 49.6144% (minimum 70%, Missing); retina: 37.8431% (minimum 75%, Missing); salivary gland: 47.4201% (minimum 70%, Missing); skeletal muscle: 56.7647% (minimum 75%, Missing); skin: 61.4650% (minimum 65%, Missing); small intestine: 43.0804% (minimum 75%, Missing); smooth muscle: 54.8295% (minimum 65%, Supported); spinal cord: 64.1196% (minimum 75%, Missing); spleen: 43.7642% (minimum 65%, Missing); stomach: 49.4872% (minimum 70%, Missing); thymus: 57.7844% (minimum 65%, Missing); thyroid gland: 57.6119% (minimum 65%, Missing); tongue: 55.7803% (minimum 70%, Missing); urinary bladder: 54.5198% (minimum 70%, Missing)",-0.212358,-0.297077,-0.371569,0,13,partial,31.7,28.6,24.8,"retina: 31.7 nTPM (vital, limit 1); bone marrow: 30.2 nTPM (vital, limit 1); lymph node: 28.6 nTPM (protected, limit 3); parathyroid gland: 26.2 nTPM (protected, limit 3); small intestine: 25.5 nTPM (vital, limit 1); spleen: 24.8 nTPM (manageable, limit 5); salivary gland: 21.4 nTPM (protected, limit 3); pancreas: 20.8 nTPM (vital, limit 1); heart muscle: 20.4 nTPM (vital, limit 3); cerebral cortex: 20 nTPM (vital, limit 1); stomach: 19.7 nTPM (protected, limit 3); rectum: 19.6 nTPM (protected, limit 3); lung: 19.3 nTPM (vital, limit 1); colon: 19.1 nTPM (protected, limit 3); pituitary gland: 17.8 nTPM (vital, limit 1); duodenum: 17.5 nTPM (vital, limit 1); cerebellum: 16.4 nTPM (vital, limit 1); urinary bladder: 16.1 nTPM (protected, limit 3); smooth muscle: 15.9 nTPM (vital, limit 3); adipose tissue: 15.7 nTPM (manageable, limit 15); tongue: 15.3 nTPM (protected, limit 3); skeletal muscle: 14.7 nTPM (vital, limit 1); thyroid gland: 14.2 nTPM (manageable, limit 5); thymus: 14.1 nTPM (manageable, limit 5); liver: 13.4 nTPM (vital, limit 3); esophagus: 12.2 nTPM (protected, limit 6); skin: 12.1 nTPM (manageable, limit 5); kidney: 11.8 nTPM (vital, limit 1); adrenal gland: 11.1 nTPM (vital, limit 1); hippocampal formation: 11 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); hypothalamus: 10.3 nTPM (vital, limit 1); choroid plexus: 9.6 nTPM (vital, limit 1); amygdala: 9 nTPM (vital, limit 1); basal ganglia: 8.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Supported); bronchus / basal cells: Medium (Supported); bronchus / ciliated cells (cell body): High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endocrine cells: High (Supported); colon / enterocytes: High (Supported); colon / goblet cells: High (Supported); colon / mucosal lymphoid cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / enterocytes: High (Supported); duodenum / goblet cells: High (Supported); duodenum / paneth cells: High (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Low (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / basal cells: High (Supported); nasopharynx / ciliated cells (cell body): High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / endocrine cells: High (Supported); rectum / enterocytes: High (Supported); rectum / goblet cells: High (Supported); rectum / mucosal lymphoid cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: Low (Supported); small intestine / endocrine cells: High (Supported); small intestine / enterocytes: High (Supported); small intestine / goblet cells: High (Supported); small intestine / paneth cells: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: High (Supported),80,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; appendix / enterocytes; appendix / germinal center cells; appendix / goblet cells; appendix / non-germinal center cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / melanocytes; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENTPD4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000197233,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR1J2,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000197275,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 71.0145% (minimum 75%, Missing); choroid plexus: 67.1233% (minimum 75%, Missing); lymph node: 64.4737% (minimum 70%, Missing); retina: 41.8803% (minimum 75%, Missing); thymus: 54.4444% (minimum 65%, Missing)",-0.105556,-0.0552632,-0.331197,0,4,partial,6.8,2.7,4.1,"retina: 6.8 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebellum / Purkinje cells: Low (Enhanced); cerebral cortex / endothelial cells: Low (Enhanced); cerebral cortex / glial cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / cholangiocytes: Low (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); parathyroid gland / glandular cells: High (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Low (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); spleen / cells in white pulp: Medium (Enhanced); stomach 1 / glandular cells: Medium (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RAD54B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000197279,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.181169,0.0559055,0.0466805,0,80,unavailable,4.9,6.2,3.9,"parathyroid gland: 6.2 nTPM (protected, limit 3); choroid plexus: 4.9 nTPM (vital, limit 1); pancreas: 4.6 nTPM (vital, limit 1); kidney: 4.4 nTPM (vital, limit 1); rectum: 4.3 nTPM (protected, limit 3); pituitary gland: 3.7 nTPM (vital, limit 1); urinary bladder: 3.3 nTPM (protected, limit 3); stomach: 3.2 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF165,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000197309,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR10D3,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000197343,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.2500% (minimum 65%, Missing); adrenal gland: 55.5985% (minimum 75%, Missing); amygdala: 63.7168% (minimum 75%, Missing); basal ganglia: 65.4545% (minimum 75%, Missing); bone marrow: 62.0690% (minimum 75%, Missing); cerebellum: 63.4361% (minimum 75%, Missing); cerebral cortex: 55.1724% (minimum 75%, Missing); choroid plexus: 58.5366% (minimum 75%, Missing); colon: 48.9796% (minimum 70%, Missing); duodenum: 48.4848% (minimum 75%, Missing); esophagus: 35.4680% (minimum 70%, Missing); heart muscle: 64.0000% (minimum 75%, Missing); hippocampal formation: 63.7168% (minimum 75%, Missing); hypothalamus: 63.1579% (minimum 75%, Missing); kidney: 51.9856% (minimum 75%, Missing); liver: 50.0000% (minimum 75%, Uncertain); lung: 49.3151% (minimum 75%, Missing); lymph node: 42.8571% (minimum 70%, Missing); midbrain: 57.6000% (minimum 75%, Missing); pancreas: 41.2607% (minimum 75%, Missing); parathyroid gland: 50.8834% (minimum 70%, Uncertain); pituitary gland: 64.2857% (minimum 75%, Missing); rectum: 55.8140% (minimum 70%, Missing); retina: 63.7168% (minimum 75%, Missing); salivary gland: 47.0588% (minimum 70%, Missing); skeletal muscle: 54.1353% (minimum 75%, Missing); skin: 44.5820% (minimum 65%, Missing); small intestine: 51.6129% (minimum 75%, Missing); smooth muscle: 56.0311% (minimum 75%, Missing); spinal cord: 51.6129% (minimum 75%, Missing); spleen: 51.0638% (minimum 65%, Missing); stomach: 45.1411% (minimum 70%, Missing); thymus: 39.5604% (minimum 65%, Missing); thyroid gland: 55.5985% (minimum 65%, Missing); tongue: 52.5547% (minimum 70%, Missing); urinary bladder: 44.3077% (minimum 70%, Missing)",-0.254396,-0.34532,-0.337393,0,2,partial,20.5,26.2,22,"esophagus: 26.2 nTPM (protected, limit 3); thymus: 22 nTPM (manageable, limit 5); pancreas: 20.5 nTPM (vital, limit 1); lymph node: 19.2 nTPM (protected, limit 3); urinary bladder: 18.1 nTPM (protected, limit 3); skin: 17.9 nTPM (manageable, limit 5); stomach: 17.5 nTPM (protected, limit 3); salivary gland: 16.2 nTPM (protected, limit 3); duodenum: 15.3 nTPM (vital, limit 1); colon: 15 nTPM (protected, limit 3); lung: 14.8 nTPM (vital, limit 1); liver: 14.4 nTPM (vital, limit 1); parathyroid gland: 13.9 nTPM (protected, limit 3); spleen: 13.8 nTPM (manageable, limit 5); spinal cord: 13.5 nTPM (vital, limit 1); small intestine: 13.5 nTPM (vital, limit 1); kidney: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 3); skeletal muscle: 12.2 nTPM (vital, limit 1); cerebral cortex: 11.7 nTPM (vital, limit 1); adrenal gland: 11.5 nTPM (vital, limit 1); thyroid gland: 11.5 nTPM (manageable, limit 5); rectum: 11.4 nTPM (protected, limit 3); smooth muscle: 11.3 nTPM (vital, limit 1); adipose tissue: 11.2 nTPM (manageable, limit 5); midbrain: 10.6 nTPM (vital, limit 1); choroid plexus: 10.2 nTPM (vital, limit 1); bone marrow: 8.8 nTPM (vital, limit 1); hypothalamus: 8.4 nTPM (vital, limit 1); cerebellum: 8.3 nTPM (vital, limit 1); retina: 8.2 nTPM (vital, limit 1); hippocampal formation: 8.2 nTPM (vital, limit 1); amygdala: 8.2 nTPM (vital, limit 1); heart muscle: 8.1 nTPM (vital, limit 1); pituitary gland: 8 nTPM (vital, limit 1); basal ganglia: 7.6 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / chondrocytes: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF655,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000197360,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 64.5390% (minimum 75%, Missing); cerebral cortex: 73.9837% (minimum 75%, Missing); pancreas: 20.2222% (minimum 75%, Missing)",0.0191176,0.0109375,-0.547778,0,80,unavailable,35.9,3.7,4.5,"pancreas: 35.9 nTPM (vital, limit 1); basal ganglia: 5 nTPM (vital, limit 1); parathyroid gland: 3.7 nTPM (protected, limit 3); cerebral cortex: 3.2 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); smooth muscle: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF98,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000197372,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.3564% (minimum 65%, Missing); adrenal gland: 71.0383% (minimum 75%, Missing); amygdala: 73.0337% (minimum 75%, Missing); bone marrow: 53.7190% (minimum 75%, Missing); cerebellum: 72.2222% (minimum 75%, Missing); cerebral cortex: 54.8523% (minimum 75%, Missing); colon: 61.9048% (minimum 70%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 69.1489% (minimum 70%, Missing); hippocampal formation: 71.4286% (minimum 75%, Missing); hypothalamus: 73.8636% (minimum 75%, Missing); kidney: 72.2222% (minimum 75%, Missing); liver: 67.3575% (minimum 75%, Missing); lung: 66.3265% (minimum 75%, Missing); lymph node: 50.7812% (minimum 70%, Missing); pancreas: 63.7255% (minimum 75%, Missing); parathyroid gland: 64.3564% (minimum 70%, Missing); rectum: 52.4194% (minimum 70%, Missing); retina: 55.7940% (minimum 75%, Missing); salivary gland: 66.3265% (minimum 70%, Missing); skin: 57.7778% (minimum 65%, Missing); small intestine: 69.1489% (minimum 75%, Missing); spleen: 58.5586% (minimum 65%, Missing); stomach: 59.6330% (minimum 70%, Missing); thymus: 56.0345% (minimum 65%, Missing); thyroid gland: 61.0329% (minimum 65%, Missing)",-0.0896552,-0.192187,-0.21281,0,80,unavailable,11.2,12.6,10.2,"lymph node: 12.6 nTPM (protected, limit 3); rectum: 11.8 nTPM (protected, limit 3); bone marrow: 11.2 nTPM (vital, limit 1); cerebral cortex: 10.7 nTPM (vital, limit 1); retina: 10.3 nTPM (vital, limit 1); thymus: 10.2 nTPM (manageable, limit 5); skin: 9.5 nTPM (manageable, limit 5); spleen: 9.2 nTPM (manageable, limit 5); stomach: 8.8 nTPM (protected, limit 3); thyroid gland: 8.3 nTPM (manageable, limit 5); colon: 8 nTPM (protected, limit 3); pancreas: 7.4 nTPM (vital, limit 1); adipose tissue: 7.2 nTPM (manageable, limit 5); parathyroid gland: 7.2 nTPM (protected, limit 3); salivary gland: 6.6 nTPM (protected, limit 3); lung: 6.6 nTPM (vital, limit 1); duodenum: 6.5 nTPM (vital, limit 1); liver: 6.3 nTPM (vital, limit 1); small intestine: 5.8 nTPM (vital, limit 1); esophagus: 5.8 nTPM (protected, limit 3); urinary bladder: 5.3 nTPM (protected, limit 3); adrenal gland: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); kidney: 5 nTPM (vital, limit 1); cerebellum: 5 nTPM (vital, limit 1); amygdala: 4.8 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); basal ganglia: 4.3 nTPM (vital, limit 1); smooth muscle: 4 nTPM (vital, limit 1); choroid plexus: 3.8 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); tongue: 3.5 nTPM (protected, limit 3); skeletal muscle: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF675,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000197410,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 72.2222% (minimum 75%, Missing); basal ganglia: 37.1429% (minimum 75%, Missing); cerebral cortex: 43.3333% (minimum 75%, Missing); colon: 43.3333% (minimum 70%, Missing); hippocampal formation: 68.4211% (minimum 75%, Missing); hypothalamus: 61.9048% (minimum 75%, Missing); midbrain: 68.4211% (minimum 75%, Missing); pituitary gland: 72.2222% (minimum 75%, Missing); stomach: 52.0000% (minimum 70%, Missing); urinary bladder: 68.4211% (minimum 70%, Missing)",0.216667,-0.266667,-0.378571,0,80,unavailable,2.2,1.7,0.2,"basal ganglia: 2.2 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DCHS2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000197416,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 11.6694% (minimum 75%, Missing)",0.35,0.2,-0.633306,0,3,partial,54.5,2.4,0,"retina: 54.5 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced),52,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FABP12,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000197437,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR13G1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000197557,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"retina: 54.5455% (minimum 75%, Missing)",0.0318182,0.0357616,-0.204545,0,8,partial,8,5.5,6.9,"retina: 8 nTPM (vital, limit 1); kidney: 4.8 nTPM (vital, limit 3); heart muscle: 3.2 nTPM (vital, limit 3); pancreas: 3.2 nTPM (vital, limit 3); choroid plexus: 3.1 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IFT70A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000197566,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebral cortex: 72.3077% (minimum 75%, Missing); kidney: 72.3077% (minimum 75%, Missing); lung: 71.2121% (minimum 75%, Missing); lymph node: 66.1972% (minimum 70%, Missing); parathyroid gland: 66.1972% (minimum 70%, Missing); retina: 64.3836% (minimum 75%, Missing); smooth muscle: 71.2121% (minimum 75%, Missing); spinal cord: 73.4375% (minimum 75%, Missing); spleen: 58.0247% (minimum 65%, Missing); thymus: 61.0390% (minimum 65%, Missing)",-0.0697531,-0.0380282,-0.106164,0,1,partial,2.6,2.4,3.4,"retina: 2.6 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: Low (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 2 / chondrocytes: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF624,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000197584,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.316387,0.22246,0.110349,0,0,routine_complete,5.6,2.9,1.2,"heart muscle: 5.6 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); cerebral cortex: 4.8 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); midbrain: 2.4 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KCNMB2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000197587,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"midbrain: 69.2308% (minimum 75%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 56.2500% (minimum 75%, Missing)",0.168182,0.118182,-0.1875,0,80,unavailable,0.7,0.2,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DMBX1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000197617,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,9,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,VN1R5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000197651,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCER1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000197653,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.101064,0,6,partial,1.2,0.1,0.1,,adrenal gland / glandular cells: Low (Enhanced); bronchus / ciliated cells (cilia axoneme): Medium (Enhanced); bronchus / ciliated cells (tip of cilia): Medium (Enhanced); choroid plexus / ependymal cells: Medium (Enhanced); kidney / cells in tubules: Low (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAH10,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000197683,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"skin: 6.5000% (minimum 65%, Missing)",-0.585,0.3,0.25,0,80,unavailable,0,0,18.7,"skin: 18.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,KRTAP26-1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000197714,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 55.0000% (minimum 65%, Missing); adrenal gland: 31.4286% (minimum 75%, Missing); basal ganglia: 73.3333% (minimum 75%, Missing); bone marrow: 27.1605% (minimum 75%, Missing); cerebellum: 64.7059% (minimum 75%, Missing); cerebral cortex: 68.7500% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); esophagus: 64.7059% (minimum 70%, Missing); heart muscle: 61.1111% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); liver: 61.1111% (minimum 75%, Missing); lung: 62.8571% (minimum 75%, Missing); pancreas: 68.7500% (minimum 75%, Missing); parathyroid gland: 62.8571% (minimum 70%, Missing); pituitary gland: 57.8947% (minimum 75%, Missing); retina: 46.8085% (minimum 75%, Missing); salivary gland: 62.8571% (minimum 70%, Missing); skeletal muscle: 59.4595% (minimum 75%, Missing); skin: 55.0000% (minimum 65%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 70.9677% (minimum 75%, Missing); spleen: 61.1111% (minimum 65%, Missing); thyroid gland: 61.1111% (minimum 65%, Missing); tongue: 64.7059% (minimum 70%, Missing); urinary bladder: 66.6667% (minimum 70%, Missing)",-0.1,-0.0714286,-0.478395,0,80,unavailable,5.9,1.3,1.8,"bone marrow: 5.9 nTPM (vital, limit 1); adrenal gland: 4.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF460,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000197748,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 36.4590% (minimum 75%, Missing)",0.264474,0.239189,-0.38541,0,80,unavailable,96.9,3.6,5.2,"choroid plexus: 96.9 nTPM (vital, limit 1); hypothalamus: 11.9 nTPM (vital, limit 1); retina: 10.4 nTPM (vital, limit 1); basal ganglia: 9.9 nTPM (vital, limit 1); pituitary gland: 9.8 nTPM (vital, limit 1); hippocampal formation: 9.3 nTPM (vital, limit 1); lung: 7.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); thyroid gland: 5.2 nTPM (manageable, limit 5); parathyroid gland: 3.6 nTPM (protected, limit 3); midbrain: 2.7 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP43,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000197768,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.319484,0.269484,0.165743,0,80,unavailable,3.8,1.3,1.3,"duodenum: 3.8 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,STPG3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000197779,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.5238% (minimum 60%, Approved); adrenal gland: 58.1395% (minimum 75%, Missing); amygdala: 65.7895% (minimum 75%, Missing); basal ganglia: 65.7895% (minimum 75%, Missing); bone marrow: 43.8596% (minimum 70%, Approved); cerebellum: 56.8182% (minimum 75%, Missing); cerebral cortex: 54.3478% (minimum 75%, Missing); choroid plexus: 59.5238% (minimum 75%, Missing); colon: 52.0833% (minimum 70%, Missing); duodenum: 62.5000% (minimum 75%, Missing); esophagus: 54.3478% (minimum 70%, Missing); heart muscle: 42.3729% (minimum 75%, Missing); hippocampal formation: 67.5676% (minimum 75%, Missing); hypothalamus: 69.4444% (minimum 75%, Missing); kidney: 50.0000% (minimum 75%, Missing); liver: 62.5000% (minimum 75%, Missing); lung: 56.8182% (minimum 75%, Missing); lymph node: 53.1915% (minimum 70%, Missing); midbrain: 60.9756% (minimum 75%, Missing); pancreas: 59.5238% (minimum 75%, Missing); parathyroid gland: 42.3729% (minimum 70%, Missing); pituitary gland: 53.1915% (minimum 75%, Missing); rectum: 47.1698% (minimum 70%, Missing); retina: 37.3134% (minimum 75%, Missing); salivary gland: 62.5000% (minimum 70%, Missing); skeletal muscle: 58.1395% (minimum 75%, Missing); skin: 41.6667% (minimum 65%, Missing); small intestine: 60.9756% (minimum 75%, Missing); smooth muscle: 53.1915% (minimum 70%, Approved); spinal cord: 60.9756% (minimum 75%, Missing); spleen: 48.0769% (minimum 65%, Missing); stomach: 59.5238% (minimum 70%, Missing); thymus: 46.2963% (minimum 65%, Missing); thyroid gland: 47.1698% (minimum 65%, Missing); urinary bladder: 55.5556% (minimum 70%, Missing)",-0.233333,-0.276271,-0.376866,0,2,partial,4.2,3.4,3.5,"retina: 4.2 nTPM (vital, limit 1); heart muscle: 3.4 nTPM (vital, limit 1); parathyroid gland: 3.4 nTPM (protected, limit 3); bone marrow: 3.2 nTPM (vital, limit 2); kidney: 2.5 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 2); pituitary gland: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); choroid plexus: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF81,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000197798,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 67.0968% (minimum 75%, Missing); amygdala: 59.4286% (minimum 75%, Missing); basal ganglia: 47.4886% (minimum 75%, Missing); cerebral cortex: 57.9387% (minimum 75%, Missing); choroid plexus: 41.1067% (minimum 75%, Missing); colon: 47.2727% (minimum 70%, Missing); duodenum: 53.6082% (minimum 75%, Missing); heart muscle: 54.1667% (minimum 75%, Missing); hippocampal formation: 63.6086% (minimum 75%, Missing); hypothalamus: 65.8228% (minimum 75%, Missing); kidney: 67.5325% (minimum 75%, Missing); liver: 70.5085% (minimum 75%, Missing); lung: 56.9863% (minimum 75%, Missing); lymph node: 62.6506% (minimum 70%, Missing); midbrain: 64.0000% (minimum 75%, Missing); pituitary gland: 70.2703% (minimum 75%, Missing); rectum: 47.5973% (minimum 70%, Missing); retina: 70.2703% (minimum 75%, Missing); skeletal muscle: 49.5238% (minimum 75%, Missing); small intestine: 62.0896% (minimum 75%, Missing); smooth muscle: 60.2899% (minimum 75%, Missing); spinal cord: 63.0303% (minimum 75%, Missing); stomach: 58.9235% (minimum 70%, Missing); thymus: 60.2899% (minimum 65%, Missing); tongue: 56.9863% (minimum 70%, Missing); urinary bladder: 61.3569% (minimum 70%, Missing)",-0.0471014,-0.227273,-0.338933,0,6,partial,29.8,23.2,13.7,"choroid plexus: 29.8 nTPM (vital, limit 1); colon: 23.2 nTPM (protected, limit 3); basal ganglia: 23 nTPM (vital, limit 1); rectum: 22.9 nTPM (protected, limit 3); skeletal muscle: 21.2 nTPM (vital, limit 1); duodenum: 18 nTPM (vital, limit 1); heart muscle: 17.6 nTPM (vital, limit 1); tongue: 15.7 nTPM (protected, limit 3); lung: 15.7 nTPM (vital, limit 1); cerebral cortex: 15.1 nTPM (vital, limit 1); stomach: 14.5 nTPM (protected, limit 3); amygdala: 14.2 nTPM (vital, limit 1); smooth muscle: 13.7 nTPM (vital, limit 1); thymus: 13.7 nTPM (manageable, limit 5); urinary bladder: 13.1 nTPM (protected, limit 3); small intestine: 12.7 nTPM (vital, limit 1); lymph node: 12.4 nTPM (protected, limit 3); spinal cord: 12.2 nTPM (vital, limit 1); hippocampal formation: 11.9 nTPM (vital, limit 1); midbrain: 11.7 nTPM (vital, limit 1); hypothalamus: 10.8 nTPM (vital, limit 1); spleen: 10.2 nTPM (manageable, limit 5); adrenal gland: 10.2 nTPM (vital, limit 1); kidney: 10 nTPM (vital, limit 1); thyroid gland: 9.9 nTPM (manageable, limit 5); pituitary gland: 8.8 nTPM (vital, limit 1); retina: 8.8 nTPM (vital, limit 1); liver: 8.7 nTPM (vital, limit 1); salivary gland: 7.8 nTPM (protected, limit 3); parathyroid gland: 7.4 nTPM (protected, limit 3); esophagus: 7.4 nTPM (protected, limit 3); cerebellum: 5.6 nTPM (vital, limit 1); pancreas: 5.5 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); bone marrow: 4.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type II: High (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: High (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM118B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000197826,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.346255,0.3,0.0891167,0,6,partial,5.1,0.1,0.5,"choroid plexus: 5.1 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); hippocampal formation: 2.8 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1)",nasopharynx / ciliated cells (ciliary rootlets): Low (Approved),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,gallbladder; lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP299,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000197849,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing)",0.35,0.3,-0.0833333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR8G1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000197863,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 69.4805% (minimum 75%, Missing); amygdala: 74.3056% (minimum 75%, Missing); basal ganglia: 74.8252% (minimum 75%, Missing); cerebral cortex: 70.3947% (minimum 75%, Missing); choroid plexus: 68.1529% (minimum 75%, Missing); duodenum: 73.7931% (minimum 75%, Missing); heart muscle: 66.8750% (minimum 75%, Uncertain); kidney: 65.2439% (minimum 75%, Missing); liver: 55.7292% (minimum 75%, Missing); lung: 74.8252% (minimum 75%, Missing); lymph node: 66.8750% (minimum 70%, Missing); pancreas: 71.3333% (minimum 75%, Missing); parathyroid gland: 65.6442% (minimum 70%, Uncertain); retina: 57.8378% (minimum 75%, Missing); skeletal muscle: 69.0323% (minimum 75%, Missing); skin: 53.7688% (minimum 65%, Missing); small intestine: 74.8252% (minimum 75%, Missing); stomach: 69.4805% (minimum 70%, Missing); thyroid gland: 57.8378% (minimum 65%, Missing); tongue: 69.0323% (minimum 70%, Missing)",-0.112312,-0.0435583,-0.192708,0,2,partial,8.5,5.6,9.2,"skin: 9.2 nTPM (manageable, limit 5); liver: 8.5 nTPM (vital, limit 1); thyroid gland: 7.8 nTPM (manageable, limit 5); retina: 7.8 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); parathyroid gland: 5.6 nTPM (protected, limit 3); lymph node: 5.3 nTPM (protected, limit 3); heart muscle: 5.3 nTPM (vital, limit 1); choroid plexus: 5 nTPM (vital, limit 1); tongue: 4.8 nTPM (protected, limit 3); skeletal muscle: 4.8 nTPM (vital, limit 1); stomach: 4.7 nTPM (protected, limit 3); adrenal gland: 4.7 nTPM (vital, limit 1); cerebral cortex: 4.5 nTPM (vital, limit 1); pancreas: 4.3 nTPM (vital, limit 1); esophagus: 4.2 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); amygdala: 3.7 nTPM (vital, limit 1); lung: 3.6 nTPM (vital, limit 1); basal ganglia: 3.6 nTPM (vital, limit 1); small intestine: 3.6 nTPM (vital, limit 1); urinary bladder: 3.5 nTPM (protected, limit 3); midbrain: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); smooth muscle: 3.2 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: High (Uncertain); duodenum / glandular cells: High (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: High (Uncertain); liver / hepatocytes: High (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: High (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / chondrocytes: High (Uncertain); soft tissue 1 / fibroblasts: High (Uncertain); soft tissue 2 / fibroblasts: High (Uncertain); soft tissue 2 / peripheral nerve: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF790,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000197889,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.330198,0.280198,0.15,0,80,unavailable,1.1,0.2,0.2,"basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MEIG1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000197928,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.140909,0.123864,0.0437956,0,6,partial,11.3,9.3,11.5,"thyroid gland: 11.5 nTPM (manageable, limit 5); retina: 11.3 nTPM (vital, limit 1); heart muscle: 11 nTPM (vital, limit 1); parathyroid gland: 9.3 nTPM (protected, limit 3); thymus: 9 nTPM (manageable, limit 5); smooth muscle: 9 nTPM (vital, limit 1); skin: 8.7 nTPM (manageable, limit 5); cerebral cortex: 7.7 nTPM (vital, limit 1); salivary gland: 7.6 nTPM (protected, limit 3); urinary bladder: 7.5 nTPM (protected, limit 3); tongue: 6.9 nTPM (protected, limit 3); colon: 6.6 nTPM (protected, limit 3); kidney: 6.2 nTPM (vital, limit 1); lymph node: 6.2 nTPM (protected, limit 4); lung: 6.1 nTPM (vital, limit 1); adrenal gland: 6.1 nTPM (vital, limit 1); bone marrow: 5.4 nTPM (vital, limit 1); esophagus: 5.3 nTPM (protected, limit 3); pancreas: 5.2 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 3); skeletal muscle: 5.1 nTPM (vital, limit 1); pituitary gland: 4.7 nTPM (vital, limit 1); spinal cord: 4.6 nTPM (vital, limit 1); cerebellum: 4.4 nTPM (vital, limit 1); basal ganglia: 4 nTPM (vital, limit 1); rectum: 3.9 nTPM (protected, limit 3); amygdala: 3.9 nTPM (vital, limit 1); hippocampal formation: 3.8 nTPM (vital, limit 1); choroid plexus: 3.7 nTPM (vital, limit 1); duodenum: 3.4 nTPM (vital, limit 1); small intestine: 3.3 nTPM (vital, limit 1); midbrain: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: Low (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF677,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000197935,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.0857143,0.124194,0.00588235,0,2,partial,1,0.7,1.1,,bronchus / respiratory epithelial cells: Low (Approved); caudate / glial cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF311,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000197977,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 73.0193% (minimum 75%, Missing); cerebral cortex: 72.2458% (minimum 75%, Missing); liver: 40.1176% (minimum 75%, Missing); retina: 55.8101% (minimum 75%, Missing); spinal cord: 62.5688% (minimum 75%, Missing)",0.302514,0.083908,-0.348824,0,80,unavailable,50.9,9.4,1.7,"liver: 50.9 nTPM (vital, limit 1); retina: 27 nTPM (vital, limit 1); spinal cord: 20.4 nTPM (vital, limit 1); cerebral cortex: 13.1 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 10.9 nTPM (vital, limit 1); parathyroid gland: 9.4 nTPM (protected, limit 3); midbrain: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.1 nTPM (vital, limit 1); cerebellum: 5.8 nTPM (vital, limit 1); hypothalamus: 5.3 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); pituitary gland: 2.9 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ELOVL2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000198021,True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPANXA1,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000198028,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0,0,80,unavailable,2,0,0,"retina: 2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF560,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000198033,True,compatible,family_exclusion,True,True,True,,0.349746,0.298731,0.249492,0,80,unavailable,0.2,0.5,0.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TUBA3C,current_adaptive,False,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000198062,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,POTEH,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,True,True,True,True,True,unchanged,
ENSG00000198088,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 55.7756% (minimum 75%, Missing); choroid plexus: 61.9048% (minimum 75%, Missing); kidney: 74.7788% (minimum 75%, Missing); thyroid gland: 63.5338% (minimum 65%, Missing)",-0.0146617,0.108612,-0.192244,0,2,partial,13.4,4,9.7,"adrenal gland: 13.4 nTPM (vital, limit 1); choroid plexus: 10.4 nTPM (vital, limit 1); thyroid gland: 9.7 nTPM (manageable, limit 5); kidney: 5.7 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 2); parathyroid gland: 4 nTPM (protected, limit 3); rectum: 3.1 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1); small intestine: 2.9 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 2); lung: 1.6 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / ciliated cells (cell body): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NUP62CL,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000198092,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 24.2268% (minimum 70%, Missing); skin: 34.3066% (minimum 65%, Missing)",-0.306934,-0.457732,0.25,0,80,unavailable,0,14.7,9,"esophagus: 14.7 nTPM (protected, limit 3); skin: 9 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TMPRSS11F,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000198129,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,DEFB107B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000198173,True,compatible,,True,True,True,,0.35,0.3,0.215517,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM47C,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000198178,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 46.4286% (minimum 75%, Missing); lung: 68.4211% (minimum 75%, Missing); lymph node: 19.6970% (minimum 70%, Missing); spleen: 26.0000% (minimum 65%, Missing); thymus: 39.3939% (minimum 65%, Missing); urinary bladder: 56.5217% (minimum 70%, Missing)",-0.39,-0.50303,-0.285714,0,3,partial,1.5,5.3,3.7,"lymph node: 5.3 nTPM (protected, limit 3); bone marrow: 1.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CLEC4C,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000198182,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 72.7273% (minimum 75%, Missing); cerebellum: 60.6897% (minimum 75%, Missing); cerebral cortex: 70.4000% (minimum 75%, Missing); choroid plexus: 72.1311% (minimum 75%, Missing); hippocampal formation: 73.3333% (minimum 75%, Missing); hypothalamus: 72.7273% (minimum 75%, Missing); kidney: 73.3333% (minimum 75%, Missing); midbrain: 73.3333% (minimum 75%, Missing); parathyroid gland: 63.7681% (minimum 70%, Missing); pituitary gland: 62.4113% (minimum 75%, Missing); retina: 65.6716% (minimum 75%, Missing); spinal cord: 70.9677% (minimum 75%, Missing)",0.0484127,-0.0623188,-0.143103,0,80,unavailable,5.7,5,3.8,"cerebellum: 5.7 nTPM (vital, limit 1); pituitary gland: 5.3 nTPM (vital, limit 1); parathyroid gland: 5 nTPM (protected, limit 3); retina: 4.6 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); choroid plexus: 3.4 nTPM (vital, limit 1); basal ganglia: 3.3 nTPM (vital, limit 1); hypothalamus: 3.3 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); kidney: 3.2 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); adrenal gland: 2.8 nTPM (vital, limit 1); pancreas: 2.7 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); lung: 2 nTPM (vital, limit 1); skeletal muscle: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF607,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000198183,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"lung: 25.3165% (minimum 75%, Missing); pituitary gland: 33.7079% (minimum 75%, Missing)",0.245522,0.025,-0.496835,0,2,partial,17.7,3.6,0.7,"lung: 17.7 nTPM (vital, limit 1); pituitary gland: 11.8 nTPM (vital, limit 1)",nasopharynx / respiratory epithelial cells: Medium (Supported),57,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BPIFA1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000198205,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 64.8148% (minimum 70%, Approved); bone marrow: 55.5556% (minimum 70%, Approved); cerebellum: 72.9167% (minimum 75%, Missing); cerebral cortex: 59.3220% (minimum 75%, Missing); colon: 67.3077% (minimum 70%, Missing); duodenum: 72.9167% (minimum 75%, Missing); heart muscle: 62.5000% (minimum 75%, Missing); kidney: 63.6364% (minimum 75%, Missing); liver: 67.3077% (minimum 75%, Missing); lung: 66.0377% (minimum 70%, Approved); lymph node: 54.6875% (minimum 65%, Approved); pancreas: 60.3448% (minimum 75%, Missing); parathyroid gland: 57.3770% (minimum 70%, Missing); retina: 67.3077% (minimum 75%, Missing); salivary gland: 68.6275% (minimum 70%, Missing); skeletal muscle: 53.8462% (minimum 75%, Missing); small intestine: 72.9167% (minimum 75%, Missing); smooth muscle: 62.5000% (minimum 70%, Approved); spleen: 53.0303% (minimum 60%, Approved); stomach: 59.3220% (minimum 70%, Missing); thymus: 61.4035% (minimum 65%, Missing); thyroid gland: 54.6875% (minimum 65%, Missing); tongue: 54.6875% (minimum 70%, Missing); urinary bladder: 67.3077% (minimum 70%, Missing)",-0.103125,-0.153125,-0.211538,0,5,partial,3,2.9,3.1,"skeletal muscle: 3 nTPM (vital, limit 1); bone marrow: 2.8 nTPM (vital, limit 2); cerebral cortex: 2.4 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 2); kidney: 2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZXDA,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000198283,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR5B21,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000198298,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.3704% (minimum 75%, Missing); basal ganglia: 74.5098% (minimum 75%, Missing); cerebellum: 71.6981% (minimum 75%, Missing); cerebral cortex: 74.5098% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); duodenum: 70.3704% (minimum 75%, Missing); esophagus: 67.8571% (minimum 70%, Missing); heart muscle: 74.5098% (minimum 75%, Missing); hippocampal formation: 74.5098% (minimum 75%, Missing); kidney: 65.5172% (minimum 75%, Missing); liver: 69.0909% (minimum 75%, Missing); lymph node: 55.0725% (minimum 70%, Missing); midbrain: 73.0769% (minimum 75%, Missing); pancreas: 48.7179% (minimum 75%, Missing); rectum: 67.8571% (minimum 70%, Missing); salivary gland: 69.0909% (minimum 70%, Missing); skeletal muscle: 55.8824% (minimum 75%, Missing); skin: 54.2857% (minimum 65%, Missing); small intestine: 71.6981% (minimum 75%, Missing); smooth muscle: 73.0769% (minimum 75%, Missing); spinal cord: 73.0769% (minimum 75%, Missing); spleen: 64.4068% (minimum 65%, Missing); stomach: 63.3333% (minimum 70%, Missing); tongue: 61.2903% (minimum 70%, Missing)",-0.107143,-0.149275,-0.262821,0,80,unavailable,4,3.1,3.2,"pancreas: 4 nTPM (vital, limit 1); lymph node: 3.1 nTPM (protected, limit 3); skeletal muscle: 3 nTPM (vital, limit 1); kidney: 2 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF485,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000198326,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.242322,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TMEM239,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000198346,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"duodenum: 73.4375% (minimum 75%, Missing); lymph node: 69.1176% (minimum 70%, Missing); parathyroid gland: 67.1429% (minimum 70%, Missing); small intestine: 74.6032% (minimum 75%, Missing)",0.0411765,-0.0285714,-0.015625,0,80,unavailable,1.7,2.3,2.1,"duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); bone marrow: 1.3 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF813,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000198390,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 2.2472% (minimum 65%, Missing)",-0.627528,0.3,0.25,0,80,unavailable,0,0,8.7,"skin: 8.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KRTAP13-1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000198440,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 69.6078% (minimum 75%, Missing); basal ganglia: 70.2970% (minimum 75%, Missing); cerebellum: 63.9640% (minimum 75%, Missing); cerebral cortex: 65.7407% (minimum 75%, Missing); hippocampal formation: 68.9320% (minimum 75%, Missing); hypothalamus: 70.2970% (minimum 75%, Missing); kidney: 72.4490% (minimum 75%, Missing); liver: 73.9583% (minimum 75%, Missing); lung: 72.4490% (minimum 75%, Missing); midbrain: 68.9320% (minimum 75%, Missing); pancreas: 73.9583% (minimum 75%, Missing); parathyroid gland: 64.5455% (minimum 70%, Missing); pituitary gland: 73.1959% (minimum 75%, Missing); retina: 64.5455% (minimum 75%, Missing); smooth muscle: 73.9583% (minimum 75%, Missing); spinal cord: 67.6190% (minimum 75%, Missing); tongue: 69.6078% (minimum 70%, Missing)",0.0326923,-0.0545455,-0.11036,0,80,unavailable,4,3.9,3.3,"cerebellum: 4 nTPM (vital, limit 1); parathyroid gland: 3.9 nTPM (protected, limit 3); retina: 3.9 nTPM (vital, limit 1); cerebral cortex: 3.7 nTPM (vital, limit 1); spinal cord: 3.4 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1); tongue: 3.1 nTPM (protected, limit 3); amygdala: 3.1 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); liver: 2.5 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF583,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000198445,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCT8L2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000198453,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.7363% (minimum 65%, Missing); adrenal gland: 56.8627% (minimum 75%, Missing); amygdala: 54.2056% (minimum 75%, Missing); basal ganglia: 58.0000% (minimum 75%, Missing); cerebellum: 49.5726% (minimum 75%, Missing); cerebral cortex: 57.4257% (minimum 75%, Missing); choroid plexus: 63.7363% (minimum 75%, Missing); colon: 62.3656% (minimum 70%, Missing); esophagus: 69.8795% (minimum 70%, Missing); heart muscle: 65.9091% (minimum 75%, Missing); hippocampal formation: 55.7692% (minimum 75%, Missing); hypothalamus: 51.7857% (minimum 75%, Missing); kidney: 65.1685% (minimum 75%, Missing); liver: 73.4177% (minimum 75%, Missing); lung: 69.0476% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); midbrain: 52.7273% (minimum 75%, Missing); pancreas: 65.9091% (minimum 75%, Missing); parathyroid gland: 49.5726% (minimum 70%, Missing); pituitary gland: 58.0000% (minimum 75%, Missing); retina: 40.8451% (minimum 75%, Missing); salivary gland: 62.3656% (minimum 70%, Missing); skeletal muscle: 41.7266% (minimum 75%, Missing); skin: 63.0435% (minimum 65%, Missing); small intestine: 71.6049% (minimum 75%, Missing); smooth muscle: 57.4257% (minimum 75%, Missing); spinal cord: 50.0000% (minimum 75%, Missing); spleen: 58.5859% (minimum 65%, Missing); stomach: 67.4419% (minimum 70%, Missing); thymus: 64.4444% (minimum 65%, Missing); thyroid gland: 52.2523% (minimum 65%, Missing); tongue: 57.4257% (minimum 70%, Missing); urinary bladder: 61.7021% (minimum 70%, Missing)",-0.127477,-0.204274,-0.341549,0,80,unavailable,8.4,5.9,5.3,"retina: 8.4 nTPM (vital, limit 1); skeletal muscle: 8.1 nTPM (vital, limit 1); parathyroid gland: 5.9 nTPM (protected, limit 3); cerebellum: 5.9 nTPM (vital, limit 1); spinal cord: 5.8 nTPM (vital, limit 1); hypothalamus: 5.4 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); midbrain: 5.2 nTPM (vital, limit 1); amygdala: 4.9 nTPM (vital, limit 1); hippocampal formation: 4.6 nTPM (vital, limit 1); adrenal gland: 4.4 nTPM (vital, limit 1); tongue: 4.3 nTPM (protected, limit 3); cerebral cortex: 4.3 nTPM (vital, limit 1); smooth muscle: 4.3 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); pituitary gland: 4.2 nTPM (vital, limit 1); urinary bladder: 3.6 nTPM (protected, limit 3); salivary gland: 3.5 nTPM (protected, limit 3); colon: 3.5 nTPM (protected, limit 3); choroid plexus: 3.3 nTPM (vital, limit 1); kidney: 3.1 nTPM (vital, limit 1); pancreas: 3 nTPM (vital, limit 1); heart muscle: 3 nTPM (vital, limit 1); lung: 2.6 nTPM (vital, limit 1); small intestine: 2.3 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); duodenum: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF568,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000198466,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 65.9864% (minimum 75%, Missing); amygdala: 72.9323% (minimum 75%, Missing); basal ganglia: 65.5405% (minimum 75%, Missing); bone marrow: 59.1463% (minimum 75%, Missing); cerebellum: 58.7879% (minimum 75%, Missing); cerebral cortex: 69.2857% (minimum 75%, Missing); choroid plexus: 70.8029% (minimum 75%, Missing); colon: 53.8889% (minimum 70%, Missing); duodenum: 54.8023% (minimum 75%, Missing); esophagus: 61.7834% (minimum 70%, Missing); heart muscle: 62.5806% (minimum 75%, Missing); hippocampal formation: 69.7842% (minimum 75%, Missing); hypothalamus: 68.3099% (minimum 75%, Missing); kidney: 60.6250% (minimum 75%, Missing); liver: 61.3924% (minimum 75%, Missing); lung: 61.7834% (minimum 75%, Missing); lymph node: 64.6667% (minimum 70%, Uncertain); pancreas: 52.4324% (minimum 75%, Missing); parathyroid gland: 66.8966% (minimum 70%, Missing); pituitary gland: 46.4115% (minimum 75%, Missing); rectum: 43.3036% (minimum 70%, Missing); retina: 46.4115% (minimum 75%, Missing); salivary gland: 45.3271% (minimum 70%, Missing); skeletal muscle: 69.2857% (minimum 75%, Missing); skin: 62.5806% (minimum 65%, Missing); small intestine: 55.7471% (minimum 75%, Missing); smooth muscle: 64.6667% (minimum 75%, Missing); spinal cord: 69.2857% (minimum 75%, Missing); spleen: 61.7834% (minimum 65%, Uncertain); stomach: 52.7174% (minimum 70%, Missing); thymus: 64.6667% (minimum 65%, Missing); thyroid gland: 56.3953% (minimum 65%, Missing); urinary bladder: 61.7834% (minimum 70%, Missing)",-0.0860465,-0.266964,-0.285885,0,3,partial,11.2,12.7,7.5,"rectum: 12.7 nTPM (protected, limit 3); salivary gland: 11.7 nTPM (protected, limit 3); retina: 11.2 nTPM (vital, limit 1); pituitary gland: 11.2 nTPM (vital, limit 1); pancreas: 8.8 nTPM (vital, limit 1); stomach: 8.7 nTPM (protected, limit 3); colon: 8.3 nTPM (protected, limit 3); duodenum: 8 nTPM (vital, limit 1); small intestine: 7.7 nTPM (vital, limit 1); thyroid gland: 7.5 nTPM (manageable, limit 5); cerebellum: 6.8 nTPM (vital, limit 1); bone marrow: 6.7 nTPM (vital, limit 1); kidney: 6.3 nTPM (vital, limit 1); liver: 6.1 nTPM (vital, limit 1); lung: 6 nTPM (vital, limit 1); urinary bladder: 6 nTPM (protected, limit 3); esophagus: 6 nTPM (protected, limit 3); spleen: 6 nTPM (manageable, limit 5); skin: 5.8 nTPM (manageable, limit 5); heart muscle: 5.8 nTPM (vital, limit 1); lymph node: 5.3 nTPM (protected, limit 3); smooth muscle: 5.3 nTPM (vital, limit 1); thymus: 5.3 nTPM (manageable, limit 5); basal ganglia: 5.1 nTPM (vital, limit 1); adrenal gland: 5 nTPM (vital, limit 1); parathyroid gland: 4.8 nTPM (protected, limit 3); hypothalamus: 4.5 nTPM (vital, limit 1); skeletal muscle: 4.3 nTPM (vital, limit 1); spinal cord: 4.3 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); hippocampal formation: 4.2 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); tongue: 4 nTPM (protected, limit 3); amygdala: 3.6 nTPM (vital, limit 1); midbrain: 3.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Low (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: High (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 1 / peripheral nerve: Medium (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF587,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000198471,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skeletal muscle: 38.7097% (minimum 75%, Missing)",0.35,0.3,-0.362903,0,80,unavailable,1.9,0,0,"skeletal muscle: 1.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RTP2,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000198521,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 71.5328% (minimum 75%, Missing); bone marrow: 47.8049% (minimum 75%, Missing); cerebellum: 72.5926% (minimum 75%, Missing); cerebral cortex: 62.8205% (minimum 75%, Missing); colon: 69.5035% (minimum 70%, Missing); duodenum: 71.5328% (minimum 75%, Missing); heart muscle: 67.1233% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); lung: 70.5036% (minimum 75%, Missing); lymph node: 54.7486% (minimum 70%, Missing); parathyroid gland: 60.4938% (minimum 70%, Missing); rectum: 65.7718% (minimum 70%, Missing); retina: 59.3939% (minimum 75%, Missing); skeletal muscle: 70.5036% (minimum 75%, Missing); skin: 57.6471% (minimum 65%, Missing); small intestine: 70.0000% (minimum 75%, Missing); smooth muscle: 69.5035% (minimum 75%, Missing); spinal cord: 74.8092% (minimum 75%, Missing); spleen: 60.1227% (minimum 65%, Missing); stomach: 67.1233% (minimum 70%, Missing); thymus: 50.0000% (minimum 65%, Missing); thyroid gland: 53.5519% (minimum 65%, Missing); tongue: 67.5862% (minimum 70%, Missing)",-0.15,-0.152514,-0.271951,0,80,unavailable,10.7,8.1,9.8,"bone marrow: 10.7 nTPM (vital, limit 1); thymus: 9.8 nTPM (manageable, limit 5); thyroid gland: 8.5 nTPM (manageable, limit 5); lymph node: 8.1 nTPM (protected, limit 3); skin: 7.2 nTPM (manageable, limit 5); retina: 6.7 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); parathyroid gland: 6.4 nTPM (protected, limit 3); cerebral cortex: 5.8 nTPM (vital, limit 1); rectum: 5.1 nTPM (protected, limit 3); kidney: 4.9 nTPM (vital, limit 1); stomach: 4.8 nTPM (protected, limit 3); heart muscle: 4.8 nTPM (vital, limit 1); tongue: 4.7 nTPM (protected, limit 3); smooth muscle: 4.3 nTPM (vital, limit 1); colon: 4.3 nTPM (protected, limit 3); small intestine: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); duodenum: 3.9 nTPM (vital, limit 1); adrenal gland: 3.9 nTPM (vital, limit 1); cerebellum: 3.7 nTPM (vital, limit 1); salivary gland: 3.5 nTPM (protected, limit 3); urinary bladder: 3.5 nTPM (protected, limit 3); esophagus: 3.5 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.7 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF43,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000198554,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 41.8033% (minimum 75%, Missing); colon: 65.3846% (minimum 70%, Missing); duodenum: 73.9130% (minimum 75%, Missing); esophagus: 68.0000% (minimum 70%, Missing); lymph node: 48.5714% (minimum 70%, Missing); rectum: 56.6667% (minimum 70%, Missing); thymus: 39.5349% (minimum 65%, Missing)",-0.254651,-0.214286,-0.331967,0,7,partial,7.1,5.4,7.8,"thymus: 7.8 nTPM (manageable, limit 5); bone marrow: 7.1 nTPM (vital, limit 1); lymph node: 5.4 nTPM (protected, limit 3); rectum: 3.9 nTPM (protected, limit 3); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); lung: 1.3 nTPM (vital, limit 1)",bronchus / basal cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); lung / alveolar cells: Low (Enhanced); lymph node / germinal center cells: High (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / basal cells: High (Enhanced); nasopharynx / ciliated cells (cell body): High (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Low (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 2 / epidermal cells: High (Enhanced); small intestine / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: High (Enhanced),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,WDHD1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000198573,True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPANXC,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000198586,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 63.3333% (minimum 75%, Missing); amygdala: 61.7329% (minimum 75%, Missing); basal ganglia: 62.8676% (minimum 75%, Missing); bone marrow: 61.0714% (minimum 75%, Missing); cerebellum: 73.7069% (minimum 75%, Missing); cerebral cortex: 56.8106% (minimum 75%, Missing); choroid plexus: 68.4000% (minimum 75%, Missing); colon: 57.5758% (minimum 70%, Missing); duodenum: 65.0190% (minimum 75%, Missing); esophagus: 65.5172% (minimum 70%, Missing); heart muscle: 71.8487% (minimum 75%, Missing); hippocampal formation: 62.4088% (minimum 75%, Missing); hypothalamus: 64.2857% (minimum 75%, Missing); kidney: 57.7703% (minimum 75%, Missing); liver: 54.4586% (minimum 75%, Missing); lung: 67.8571% (minimum 75%, Missing); lymph node: 53.7736% (minimum 70%, Missing); midbrain: 61.5108% (minimum 75%, Missing); pancreas: 62.8676% (minimum 75%, Missing); parathyroid gland: 49.4220% (minimum 70%, Missing); pituitary gland: 74.0260% (minimum 75%, Missing); rectum: 58.9655% (minimum 70%, Missing); retina: 52.7778% (minimum 75%, Missing); salivary gland: 65.7692% (minimum 70%, Missing); skeletal muscle: 52.1341% (minimum 75%, Missing); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 60.2113% (minimum 75%, Missing); spinal cord: 63.3333% (minimum 75%, Missing); spleen: 57.1906% (minimum 65%, Missing); stomach: 56.6225% (minimum 70%, Missing); thymus: 56.0656% (minimum 65%, Missing); thyroid gland: 50.0000% (minimum 65%, Missing); urinary bladder: 60.2113% (minimum 70%, Missing)",-0.15,-0.20578,-0.228659,0,4,partial,15.7,17.5,17.1,"parathyroid gland: 17.5 nTPM (protected, limit 3); thyroid gland: 17.1 nTPM (manageable, limit 5); skeletal muscle: 15.7 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); lymph node: 14.7 nTPM (protected, limit 3); liver: 14.3 nTPM (vital, limit 1); thymus: 13.4 nTPM (manageable, limit 5); stomach: 13.1 nTPM (protected, limit 3); cerebral cortex: 13 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); colon: 12.6 nTPM (protected, limit 3); kidney: 12.5 nTPM (vital, limit 1); rectum: 11.9 nTPM (protected, limit 3); small intestine: 11.4 nTPM (vital, limit 1); smooth muscle: 11.3 nTPM (vital, limit 1); urinary bladder: 11.3 nTPM (protected, limit 3); bone marrow: 10.9 nTPM (vital, limit 1); midbrain: 10.7 nTPM (vital, limit 1); amygdala: 10.6 nTPM (vital, limit 1); hippocampal formation: 10.3 nTPM (vital, limit 1); pancreas: 10.1 nTPM (vital, limit 1); basal ganglia: 10.1 nTPM (vital, limit 1); adrenal gland: 9.9 nTPM (vital, limit 1); spinal cord: 9.9 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); duodenum: 9.2 nTPM (vital, limit 1); esophagus: 9 nTPM (protected, limit 3); salivary gland: 8.9 nTPM (protected, limit 3); skin: 8.3 nTPM (manageable, limit 5); lung: 8.1 nTPM (vital, limit 1); choroid plexus: 7.9 nTPM (vital, limit 1); adipose tissue: 7.4 nTPM (manageable, limit 5); heart muscle: 6.7 nTPM (vital, limit 1); cerebellum: 6.1 nTPM (vital, limit 1); pituitary gland: 6 nTPM (vital, limit 1); tongue: 5.3 nTPM (protected, limit 3)",adipose tissue / adipocytes: High (Approved); adrenal gland / glandular cells: High (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: High (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: High (Approved); cerebral cortex / glial cells: High (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: High (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: High (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: High (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Medium (Approved); liver / hepatocytes: High (Approved); lung / alveolar cells type I: High (Approved); lung / alveolar cells type II: High (Approved); lung / endothelial cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: High (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: High (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: High (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: High (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: High (Approved); soft tissue 1 / fibroblasts: High (Approved); soft tissue 1 / peripheral nerve: High (Approved); soft tissue 2 / fibroblasts: High (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TLK1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000198681,True,compatible,,True,True,True,,0.35,0.3,0.25,0,5,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEA1,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000198691,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 5.1829% (minimum 75%, Missing); kidney: 66.2338% (minimum 75%, Missing); retina: 1.4626% (minimum 75%, Missing)",0.312264,0.3,-0.735374,0,3,partial,343.6,0.2,0.4,"retina: 343.6 nTPM (vital, limit 1); choroid plexus: 93.3 nTPM (vital, limit 1); kidney: 2.6 nTPM (vital, limit 1)",kidney / collecting ducts: High (Enhanced); kidney / distal tubules: High (Enhanced); kidney / proximal tubules (cell body): High (Enhanced); retina / photoreceptor cells: High (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ABCA4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000198704,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GPX6,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000198723,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.288967,0.285222,0.175926,0,80,unavailable,1.6,0.3,1.3,"bone marrow: 1.6 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SAXO5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000198754,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.299198,0.3,0.234743,0,4,partial,6.3,0.9,3.8,"heart muscle: 6.3 nTPM (vital, limit 6); hippocampal formation: 1.1 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",kidney / distal tubules: Low (Enhanced),57,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OXCT2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000198759,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349679,0.297441,0.246008,0,2,partial,24.8,10.3,19.5,"lung: 24.8 nTPM (vital, limit 6); pituitary gland: 2.5 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EGFL6,current_adaptive,True,False,False,False,10.1158/0008-5472.CAN-16-0225,Bai 2016,False,False,False,False,False,unchanged,
ENSG00000198765,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0.1,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SYCP1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000198785,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 56.0000% (minimum 75%, Missing); cerebral cortex: 15.9091% (minimum 75%, Missing); heart muscle: 70.0000% (minimum 75%, Missing); hippocampal formation: 58.3333% (minimum 75%, Missing); hypothalamus: 42.4242% (minimum 75%, Missing); midbrain: 58.3333% (minimum 75%, Missing); retina: 63.6364% (minimum 75%, Missing)",0.0166667,0.0777778,-0.590909,0,80,unavailable,7.4,0.4,0.7,"cerebral cortex: 7.4 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GRIN3A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000198798,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEB3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000198815,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 49.3213% (minimum 65%, Missing); adrenal gland: 63.5569% (minimum 75%, Missing); amygdala: 59.7260% (minimum 75%, Missing); basal ganglia: 54.7739% (minimum 75%, Missing); bone marrow: 42.2481% (minimum 75%, Missing); cerebellum: 43.0830% (minimum 75%, Missing); cerebral cortex: 54.0943% (minimum 75%, Missing); choroid plexus: 64.3068% (minimum 75%, Missing); colon: 55.8974% (minimum 70%, Missing); duodenum: 58.7601% (minimum 75%, Missing); esophagus: 59.2391% (minimum 70%, Missing); heart muscle: 52.9126% (minimum 75%, Missing); hippocampal formation: 56.3307% (minimum 75%, Missing); hypothalamus: 58.1333% (minimum 75%, Missing); kidney: 62.6437% (minimum 75%, Missing); liver: 57.9787% (minimum 75%, Missing); lung: 54.7739% (minimum 75%, Missing); lymph node: 55.6122% (minimum 70%, Missing); midbrain: 64.6884% (minimum 75%, Missing); pancreas: 54.2289% (minimum 75%, Missing); parathyroid gland: 51.2941% (minimum 70%, Missing); pituitary gland: 56.7708% (minimum 75%, Missing); rectum: 55.3299% (minimum 70%, Missing); retina: 53.6946% (minimum 75%, Missing); salivary gland: 57.0681% (minimum 70%, Missing); skeletal muscle: 34.9359% (minimum 75%, Missing); skin: 49.5455% (minimum 65%, Missing); small intestine: 56.0411% (minimum 75%, Missing); smooth muscle: 56.0411% (minimum 75%, Missing); spinal cord: 63.7427% (minimum 75%, Missing); spleen: 56.6234% (minimum 65%, Missing); stomach: 56.1856% (minimum 70%, Missing); thymus: 50.2304% (minimum 65%, Missing); thyroid gland: 53.9604% (minimum 65%, Missing); tongue: 43.7751% (minimum 70%, Missing); urinary bladder: 55.1899% (minimum 70%, Missing)",-0.156787,-0.262249,-0.400641,0,80,unavailable,40.6,28,22.4,"skeletal muscle: 40.6 nTPM (vital, limit 1); bone marrow: 29.8 nTPM (vital, limit 1); cerebellum: 28.8 nTPM (vital, limit 1); tongue: 28 nTPM (protected, limit 3); adipose tissue: 22.4 nTPM (manageable, limit 5); skin: 22.2 nTPM (manageable, limit 5); thymus: 21.6 nTPM (manageable, limit 5); parathyroid gland: 20.7 nTPM (protected, limit 3); heart muscle: 19.4 nTPM (vital, limit 1); retina: 18.8 nTPM (vital, limit 1); thyroid gland: 18.6 nTPM (manageable, limit 5); cerebral cortex: 18.5 nTPM (vital, limit 1); pancreas: 18.4 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); basal ganglia: 18 nTPM (vital, limit 1); urinary bladder: 17.7 nTPM (protected, limit 3); rectum: 17.6 nTPM (protected, limit 3); lymph node: 17.4 nTPM (protected, limit 3); colon: 17.2 nTPM (protected, limit 3); smooth muscle: 17.1 nTPM (vital, limit 1); small intestine: 17.1 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 3); hippocampal formation: 16.9 nTPM (vital, limit 1); spleen: 16.7 nTPM (manageable, limit 5); pituitary gland: 16.6 nTPM (vital, limit 1); salivary gland: 16.4 nTPM (protected, limit 3); liver: 15.8 nTPM (vital, limit 1); hypothalamus: 15.7 nTPM (vital, limit 1); duodenum: 15.3 nTPM (vital, limit 1); esophagus: 15 nTPM (protected, limit 3); amygdala: 14.7 nTPM (vital, limit 1); kidney: 13 nTPM (vital, limit 1); adrenal gland: 12.5 nTPM (vital, limit 1); spinal cord: 12.4 nTPM (vital, limit 1); choroid plexus: 12.1 nTPM (vital, limit 1); midbrain: 11.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FOXJ3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000198816,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.6420% (minimum 60%, Approved); adrenal gland: 60.6789% (minimum 75%, Missing); amygdala: 42.6653% (minimum 75%, Missing); basal ganglia: 50.4113% (minimum 75%, Missing); cerebellum: 52.4450% (minimum 75%, Missing); cerebral cortex: 37.0787% (minimum 75%, Missing); choroid plexus: 69.6429% (minimum 75%, Missing); colon: 45.1341% (minimum 70%, Missing); duodenum: 75.0000% (minimum 75%, Missing); heart muscle: 44.7574% (minimum 75%, Missing); hippocampal formation: 43.8650% (minimum 75%, Missing); hypothalamus: 51.5315% (minimum 75%, Missing); kidney: 62.5364% (minimum 75%, Missing); liver: 56.7460% (minimum 75%, Missing); lung: 63.6027% (minimum 75%, Missing); midbrain: 49.7680% (minimum 75%, Missing); pancreas: 63.6027% (minimum 75%, Missing); parathyroid gland: 64.1735% (minimum 65%, Approved); pituitary gland: 59.1316% (minimum 75%, Missing); salivary gland: 63.3210% (minimum 65%, Approved); skeletal muscle: 33.6207% (minimum 70%, Approved); small intestine: 64.8526% (minimum 75%, Missing); spinal cord: 56.9343% (minimum 75%, Missing); stomach: 56.5590% (minimum 70%, Missing); thyroid gland: 59.6247% (minimum 65%, Missing); tongue: 37.8140% (minimum 70%, Missing); urinary bladder: 50.0876% (minimum 70%, Missing)",-0.0537526,-0.32186,-0.379213,0,3,partial,169.4,141.1,68.4,"skeletal muscle: 169.4 nTPM (vital, limit 2); cerebral cortex: 145.6 nTPM (vital, limit 1); tongue: 141.1 nTPM (protected, limit 3); amygdala: 115.3 nTPM (vital, limit 1); hippocampal formation: 109.8 nTPM (vital, limit 1); heart muscle: 105.9 nTPM (vital, limit 1); colon: 104.3 nTPM (protected, limit 3); midbrain: 86.6 nTPM (vital, limit 1); urinary bladder: 85.5 nTPM (protected, limit 3); basal ganglia: 84.4 nTPM (vital, limit 1); hypothalamus: 80.7 nTPM (vital, limit 1); cerebellum: 77.8 nTPM (vital, limit 1); adipose tissue: 68.4 nTPM (manageable, limit 10); stomach: 65.9 nTPM (protected, limit 3); liver: 65.4 nTPM (vital, limit 1); spinal cord: 64.9 nTPM (vital, limit 1); pituitary gland: 59.3 nTPM (vital, limit 1); thyroid gland: 58.1 nTPM (manageable, limit 5); adrenal gland: 55.6 nTPM (vital, limit 1); kidney: 51.4 nTPM (vital, limit 1); salivary gland: 49.7 nTPM (protected, limit 4); lung: 49.1 nTPM (vital, limit 1); pancreas: 49.1 nTPM (vital, limit 1); parathyroid gland: 47.9 nTPM (protected, limit 4); small intestine: 46.5 nTPM (vital, limit 1); spleen: 38.6 nTPM (manageable, limit 5); skin: 37.5 nTPM (manageable, limit 5); choroid plexus: 37.4 nTPM (vital, limit 1); smooth muscle: 36 nTPM (vital, limit 2); esophagus: 31 nTPM (protected, limit 3); duodenum: 28.6 nTPM (vital, limit 1); rectum: 17.7 nTPM (protected, limit 3); thymus: 13.7 nTPM (manageable, limit 5); retina: 11.4 nTPM (vital, limit 1); lymph node: 10.3 nTPM (protected, limit 3); bone marrow: 2.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: High (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: High (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF358,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000198826,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"bone marrow: 25.1592% (minimum 75%, Missing); colon: 52.3179% (minimum 70%, Missing); duodenum: 58.0882% (minimum 75%, Missing); esophagus: 61.2403% (minimum 70%, Missing); lymph node: 37.9808% (minimum 70%, Missing); midbrain: 73.1481% (minimum 75%, Missing); rectum: 48.4663% (minimum 70%, Missing); small intestine: 52.6667% (minimum 75%, Missing); smooth muscle: 63.2000% (minimum 75%, Missing); spinal cord: 55.2448% (minimum 75%, Missing); stomach: 69.9115% (minimum 70%, Missing); thymus: 23.7952% (minimum 65%, Missing)",-0.412048,-0.320192,-0.498408,0,8,partial,23.5,12.9,25.3,"thymus: 25.3 nTPM (manageable, limit 5); bone marrow: 23.5 nTPM (vital, limit 1); lymph node: 12.9 nTPM (protected, limit 3); rectum: 8.4 nTPM (protected, limit 3); colon: 7.2 nTPM (protected, limit 3); small intestine: 7.1 nTPM (vital, limit 1); spinal cord: 6.4 nTPM (vital, limit 1); duodenum: 5.7 nTPM (vital, limit 1); esophagus: 5 nTPM (protected, limit 3); smooth muscle: 4.6 nTPM (vital, limit 1); stomach: 3.4 nTPM (protected, limit 3); midbrain: 2.9 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Low (Enhanced); colon / glandular cells: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); lung / macrophages: Low (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Low (Enhanced); skin 2 / epidermal cells: Low (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 2 / peripheral nerve: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced); thyroid gland / glandular cells: Medium (Enhanced),46,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ARHGAP11A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000198865,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.2876% (minimum 65%, Missing); adrenal gland: 59.2593% (minimum 75%, Missing); amygdala: 60.6061% (minimum 75%, Missing); basal ganglia: 58.3942% (minimum 75%, Missing); cerebral cortex: 72.7273% (minimum 75%, Missing); choroid plexus: 74.7664% (minimum 75%, Missing); colon: 61.0687% (minimum 70%, Missing); duodenum: 67.7966% (minimum 75%, Missing); heart muscle: 51.6129% (minimum 75%, Missing); hippocampal formation: 57.1429% (minimum 75%, Missing); hypothalamus: 53.3333% (minimum 75%, Missing); kidney: 48.7805% (minimum 75%, Missing); liver: 4.3980% (minimum 75%, Missing); lung: 57.5540% (minimum 75%, Missing); lymph node: 52.6316% (minimum 70%, Missing); midbrain: 41.2371% (minimum 75%, Missing); pancreas: 67.2269% (minimum 75%, Missing); pituitary gland: 51.6129% (minimum 75%, Missing); small intestine: 38.0952% (minimum 75%, Missing); spinal cord: 29.9625% (minimum 75%, Missing); spleen: 35.3982% (minimum 65%, Missing); stomach: 65.0407% (minimum 70%, Missing)",-0.296018,-0.173684,-0.70602,0,4,partial,173.9,7.2,14.6,"liver: 173.9 nTPM (vital, limit 1); spinal cord: 18.7 nTPM (vital, limit 1); spleen: 14.6 nTPM (manageable, limit 5); small intestine: 13 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); kidney: 8.4 nTPM (vital, limit 1); heart muscle: 7.5 nTPM (vital, limit 1); pituitary gland: 7.5 nTPM (vital, limit 1); adipose tissue: 7.3 nTPM (manageable, limit 5); lymph node: 7.2 nTPM (protected, limit 3); hypothalamus: 7 nTPM (vital, limit 1); hippocampal formation: 6 nTPM (vital, limit 1); lung: 5.9 nTPM (vital, limit 1); basal ganglia: 5.7 nTPM (vital, limit 1); adrenal gland: 5.5 nTPM (vital, limit 1); amygdala: 5.2 nTPM (vital, limit 1); colon: 5.1 nTPM (protected, limit 3); stomach: 4.3 nTPM (protected, limit 3); pancreas: 3.9 nTPM (vital, limit 1); duodenum: 3.8 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1); retina: 2.2 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.5 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Low (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC152,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000198870,True,compatible,,True,True,True,,0.329798,0.279798,0.191748,0,80,unavailable,0.6,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,STKLD1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,True,True,True,True,gained,selectivity_revised
ENSG00000198883,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 54.1401% (minimum 75%, Missing); basal ganglia: 33.7302% (minimum 75%, Missing); cerebral cortex: 48.2955% (minimum 75%, Missing); hippocampal formation: 65.3846% (minimum 75%, Missing); hypothalamus: 28.1457% (minimum 75%, Missing)",0.35,0.288372,-0.468543,0,1,partial,21.7,0.1,0.5,"hypothalamus: 21.7 nTPM (vital, limit 1); basal ganglia: 16.7 nTPM (vital, limit 1); cerebral cortex: 9.1 nTPM (vital, limit 1); amygdala: 7.2 nTPM (vital, limit 1); hippocampal formation: 4.5 nTPM (vital, limit 1)",caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PNMA5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000198885,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.19375,0.087172,0.14404,0,80,unavailable,3.2,7.3,5,"salivary gland: 7.3 nTPM (protected, limit 3); lymph node: 3.8 nTPM (protected, limit 3); cerebellum: 3.2 nTPM (vital, limit 1); small intestine: 1.6 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ITPRIPL1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000198889,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.257143,0.182353,0.05,0,5,partial,1.5,0.8,1,"kidney: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 2 / chondrocytes: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node / germinal center cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DCAF12L1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000198919,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 74.6667% (minimum 75%, Missing); basal ganglia: 67.8788% (minimum 75%, Missing); cerebellum: 70.2929% (minimum 75%, Missing); cerebral cortex: 59.7865% (minimum 75%, Missing); choroid plexus: 60.7595% (minimum 75%, Missing); hippocampal formation: 72.4138% (minimum 75%, Missing); hypothalamus: 65.3696% (minimum 75%, Missing); pituitary gland: 58.4348% (minimum 75%, Missing); retina: 53.7600% (minimum 75%, Missing); skeletal muscle: 73.8462% (minimum 75%, Missing); tongue: 68.2927% (minimum 70%, Missing)",0.0804348,-0.0170732,-0.2124,0,4,partial,28.9,15.6,12.4,"retina: 28.9 nTPM (vital, limit 1); pituitary gland: 23.9 nTPM (vital, limit 1); cerebral cortex: 22.6 nTPM (vital, limit 1); choroid plexus: 21.7 nTPM (vital, limit 1); hypothalamus: 17.8 nTPM (vital, limit 1); basal ganglia: 15.9 nTPM (vital, limit 1); tongue: 15.6 nTPM (protected, limit 3); cerebellum: 14.2 nTPM (vital, limit 1); hippocampal formation: 12.8 nTPM (vital, limit 1); thyroid gland: 12.4 nTPM (manageable, limit 5); skeletal muscle: 11.9 nTPM (vital, limit 1); amygdala: 11.4 nTPM (vital, limit 1); heart muscle: 11.2 nTPM (vital, limit 1); kidney: 10.5 nTPM (vital, limit 1); midbrain: 10.1 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 3); adrenal gland: 9.4 nTPM (vital, limit 1); thymus: 8.3 nTPM (manageable, limit 5); spinal cord: 8.2 nTPM (vital, limit 1); parathyroid gland: 7.5 nTPM (protected, limit 4); stomach: 6.4 nTPM (protected, limit 3); lung: 6.3 nTPM (vital, limit 1); pancreas: 5.2 nTPM (vital, limit 1); smooth muscle: 5 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 3); urinary bladder: 5 nTPM (protected, limit 4); rectum: 4.5 nTPM (protected, limit 3); liver: 4.1 nTPM (vital, limit 2); small intestine: 3.8 nTPM (vital, limit 1); bone marrow: 3.8 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 3); salivary gland: 3.4 nTPM (protected, limit 3); duodenum: 3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: High (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DZIP3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000198930,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"amygdala: 43.3333% (minimum 75%, Missing); basal ganglia: 40.6250% (minimum 75%, Missing); cerebral cortex: 44.8276% (minimum 75%, Missing); hippocampal formation: 44.8276% (minimum 75%, Missing); hypothalamus: 56.5217% (minimum 75%, Missing); midbrain: 44.8276% (minimum 75%, Missing); spinal cord: 68.4211% (minimum 75%, Missing)",0.278571,0.1125,-0.34375,0,80,unavailable,1.9,0.3,0.1,"basal ganglia: 1.9 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; tonsil,False,CSAG/CSAGE cancer-testis antigen reported in chondrosarcoma; keep candidate-only until HPA specificity evidence is curated.,False,CSAG/CSAGE cancer-testis antigen reported in chondrosarcoma; keep candidate-only until HPA specificity evidence is curated.,False,,,CSAG1,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000198948,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 69.6594% (minimum 75%, Missing); basal ganglia: 63.0252% (minimum 75%, Missing); cerebral cortex: 67.7711% (minimum 75%, Missing); choroid plexus: 52.2648% (minimum 75%, Missing); hippocampal formation: 68.7023% (minimum 75%, Missing); hypothalamus: 74.8752% (minimum 75%, Missing); kidney: 60.8108% (minimum 75%, Missing); liver: 55.3506% (minimum 75%, Missing); midbrain: 65.5977% (minimum 75%, Missing); retina: 65.0289% (minimum 75%, Missing); spinal cord: 66.7656% (minimum 75%, Missing)",0.15407,0.25339,-0.227352,0,2,partial,41.1,9.8,23.8,"choroid plexus: 41.1 nTPM (vital, limit 1); liver: 36.3 nTPM (vital, limit 1); kidney: 29 nTPM (vital, limit 1); basal ganglia: 26.4 nTPM (vital, limit 1); retina: 24.2 nTPM (vital, limit 1); midbrain: 23.6 nTPM (vital, limit 1); spinal cord: 22.4 nTPM (vital, limit 1); cerebral cortex: 21.4 nTPM (vital, limit 1); hippocampal formation: 20.5 nTPM (vital, limit 1); amygdala: 19.6 nTPM (vital, limit 1); hypothalamus: 15.1 nTPM (vital, limit 1); skeletal muscle: 4.9 nTPM (vital, limit 1); pituitary gland: 4 nTPM (vital, limit 1); adrenal gland: 3.3 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / cells in tubules: Low (Enhanced); liver / hepatocytes: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MFAP3L,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000203326,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 70.0000% (minimum 75%, Missing); bone marrow: 68.6275% (minimum 75%, Missing); cerebellum: 64.8148% (minimum 75%, Missing); duodenum: 73.4266% (minimum 75%, Missing); kidney: 63.6364% (minimum 75%, Missing); lymph node: 57.6923% (minimum 70%, Missing); pancreas: 64.0244% (minimum 75%, Missing); parathyroid gland: 43.5685% (minimum 70%, Missing); pituitary gland: 66.0377% (minimum 75%, Missing); rectum: 67.7419% (minimum 70%, Missing); retina: 68.6275% (minimum 75%, Missing); skin: 56.1497% (minimum 65%, Missing); small intestine: 66.8790% (minimum 75%, Missing); spleen: 62.8743% (minimum 65%, Missing); stomach: 66.0377% (minimum 70%, Missing); thymus: 62.5000% (minimum 65%, Missing); urinary bladder: 69.0789% (minimum 70%, Missing)",-0.0885027,-0.264315,-0.113636,0,80,unavailable,6,13.6,8.2,"parathyroid gland: 13.6 nTPM (protected, limit 3); skin: 8.2 nTPM (manageable, limit 5); lymph node: 7.7 nTPM (protected, limit 3); thymus: 6.3 nTPM (manageable, limit 5); spleen: 6.2 nTPM (manageable, limit 5); kidney: 6 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); cerebellum: 5.7 nTPM (vital, limit 1); stomach: 5.4 nTPM (protected, limit 3); pituitary gland: 5.4 nTPM (vital, limit 1); small intestine: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); rectum: 5 nTPM (protected, limit 3); bone marrow: 4.8 nTPM (vital, limit 1); retina: 4.8 nTPM (vital, limit 1); urinary bladder: 4.7 nTPM (protected, limit 3); adrenal gland: 4.5 nTPM (vital, limit 1); salivary gland: 4.4 nTPM (protected, limit 3); esophagus: 4.1 nTPM (protected, limit 3); duodenum: 3.8 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); lung: 3.3 nTPM (vital, limit 1); choroid plexus: 2.8 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); liver: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); heart muscle: 2.3 nTPM (vital, limit 1); hypothalamus: 2.2 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF525,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000203666,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 73.7705% (minimum 75%, Missing); bone marrow: 62.6741% (minimum 70%, Approved); cerebral cortex: 74.5033% (minimum 75%, Missing); choroid plexus: 52.5701% (minimum 75%, Missing); heart muscle: 69.2308% (minimum 75%, Missing); hippocampal formation: 73.2899% (minimum 75%, Missing); kidney: 74.5033% (minimum 75%, Missing); lung: 69.2308% (minimum 75%, Missing); midbrain: 70.5329% (minimum 75%, Missing); parathyroid gland: 69.2308% (minimum 70%, Missing); rectum: 67.5676% (minimum 70%, Missing); retina: 59.2105% (minimum 75%, Missing); skeletal muscle: 55.4187% (minimum 75%, Missing); smooth muscle: 71.6561% (minimum 75%, Missing); spinal cord: 69.0184% (minimum 75%, Missing); thyroid gland: 51.2528% (minimum 65%, Missing)",-0.137472,-0.0243243,-0.224299,0,1,partial,20.3,10.8,21.4,"thyroid gland: 21.4 nTPM (manageable, limit 5); choroid plexus: 20.3 nTPM (vital, limit 1); skeletal muscle: 18.1 nTPM (vital, limit 1); retina: 15.5 nTPM (vital, limit 1); bone marrow: 13.4 nTPM (vital, limit 2); rectum: 10.8 nTPM (protected, limit 3); spinal cord: 10.1 nTPM (vital, limit 1); heart muscle: 10 nTPM (vital, limit 1); parathyroid gland: 10 nTPM (protected, limit 3); lung: 10 nTPM (vital, limit 1); adipose tissue: 9.5 nTPM (manageable, limit 5); midbrain: 9.4 nTPM (vital, limit 1); stomach: 9.2 nTPM (protected, limit 3); esophagus: 9 nTPM (protected, limit 3); smooth muscle: 8.9 nTPM (vital, limit 1); lymph node: 8.4 nTPM (protected, limit 3); hippocampal formation: 8.2 nTPM (vital, limit 1); adrenal gland: 8 nTPM (vital, limit 1); cerebral cortex: 7.7 nTPM (vital, limit 1); kidney: 7.7 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); salivary gland: 7.2 nTPM (protected, limit 3); pancreas: 7.2 nTPM (vital, limit 1); hypothalamus: 6.8 nTPM (vital, limit 1); basal ganglia: 6.8 nTPM (vital, limit 1); spleen: 6.5 nTPM (manageable, limit 5); urinary bladder: 6.1 nTPM (protected, limit 3); skin: 6 nTPM (manageable, limit 5); pituitary gland: 5.9 nTPM (vital, limit 1); small intestine: 5.9 nTPM (vital, limit 1); thymus: 5.5 nTPM (manageable, limit 5); tongue: 5.4 nTPM (protected, limit 3); colon: 5.2 nTPM (protected, limit 3); liver: 3.8 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: High (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: High (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: High (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: High (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / chondrocytes: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Medium (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EFCAB2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000203772,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 47.3684% (minimum 75%, Missing); amygdala: 27.6923% (minimum 75%, Missing); basal ganglia: 29.2683% (minimum 75%, Missing); cerebellum: 17.7340% (minimum 75%, Missing); cerebral cortex: 12.5436% (minimum 75%, Missing); colon: 61.0169% (minimum 70%, Missing); esophagus: 56.2500% (minimum 70%, Missing); heart muscle: 67.9245% (minimum 75%, Missing); hippocampal formation: 21.3018% (minimum 75%, Missing); hypothalamus: 35.6436% (minimum 75%, Missing); kidney: 40.4494% (minimum 75%, Missing); liver: 17.2249% (minimum 75%, Missing); lung: 69.2308% (minimum 75%, Missing); midbrain: 45.5696% (minimum 75%, Missing); pancreas: 55.3846% (minimum 75%, Missing); pituitary gland: 41.8605% (minimum 75%, Missing); salivary gland: 63.1579% (minimum 70%, Missing); skeletal muscle: 65.4545% (minimum 75%, Missing); small intestine: 52.9412% (minimum 75%, Missing); spinal cord: 52.1739% (minimum 75%, Missing); spleen: 43.9024% (minimum 65%, Missing); stomach: 50.7042% (minimum 70%, Missing); thyroid gland: 51.4286% (minimum 65%, Missing); urinary bladder: 69.2308% (minimum 70%, Missing)",-0.210976,-0.192958,-0.624564,0,80,unavailable,25.1,3.5,4.6,"cerebral cortex: 25.1 nTPM (vital, limit 1); liver: 17.3 nTPM (vital, limit 1); cerebellum: 16.7 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 9.4 nTPM (vital, limit 1); basal ganglia: 8.7 nTPM (vital, limit 1); hypothalamus: 6.5 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); pituitary gland: 5 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); adrenal gland: 4 nTPM (vital, limit 1); stomach: 3.5 nTPM (protected, limit 3); spinal cord: 3.3 nTPM (vital, limit 1); small intestine: 3.2 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); skeletal muscle: 1.9 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPRN,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000203778,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.305263,0.21206,0.0608712,0,80,unavailable,101.6,42,20.4,"choroid plexus: 101.6 nTPM (vital, limit 1); spinal cord: 100.2 nTPM (vital, limit 1); midbrain: 90.3 nTPM (vital, limit 1); amygdala: 74.3 nTPM (vital, limit 1); basal ganglia: 72 nTPM (vital, limit 1); hypothalamus: 70.2 nTPM (vital, limit 1); heart muscle: 67.7 nTPM (vital, limit 1); hippocampal formation: 64.9 nTPM (vital, limit 1); pituitary gland: 64.3 nTPM (vital, limit 1); cerebral cortex: 58.9 nTPM (vital, limit 1); parathyroid gland: 42 nTPM (protected, limit 3); retina: 34.3 nTPM (vital, limit 1); kidney: 28.4 nTPM (vital, limit 1); liver: 24.2 nTPM (vital, limit 1); cerebellum: 23.4 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 1); thyroid gland: 20.4 nTPM (manageable, limit 5); colon: 20.4 nTPM (protected, limit 3); urinary bladder: 18.4 nTPM (protected, limit 3); stomach: 18.1 nTPM (protected, limit 3); smooth muscle: 17.7 nTPM (vital, limit 1); adipose tissue: 17.6 nTPM (manageable, limit 5); lung: 14.8 nTPM (vital, limit 1); tongue: 14.7 nTPM (protected, limit 3); skeletal muscle: 13.2 nTPM (vital, limit 1); thymus: 10.6 nTPM (manageable, limit 5); salivary gland: 8.7 nTPM (protected, limit 3); pancreas: 8.3 nTPM (vital, limit 1); skin: 7.5 nTPM (manageable, limit 5); small intestine: 7.2 nTPM (vital, limit 1); esophagus: 7 nTPM (protected, limit 3); rectum: 5.2 nTPM (protected, limit 3); spleen: 5.1 nTPM (manageable, limit 5); bone marrow: 3.7 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); duodenum: 3.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM229B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000203780,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 45.2597% (minimum 75%, Missing)",0.222814,0.213478,-0.297403,0,80,unavailable,66.4,5.2,8,"choroid plexus: 66.4 nTPM (vital, limit 1); retina: 15.3 nTPM (vital, limit 1); hypothalamus: 9.5 nTPM (vital, limit 1); thyroid gland: 8 nTPM (manageable, limit 5); basal ganglia: 7.4 nTPM (vital, limit 1); pituitary gland: 7.2 nTPM (vital, limit 1); hippocampal formation: 6.9 nTPM (vital, limit 1); kidney: 5.7 nTPM (vital, limit 1); skin: 5.6 nTPM (manageable, limit 5); lung: 5.5 nTPM (vital, limit 1); stomach: 5.2 nTPM (protected, limit 3); amygdala: 5.2 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 3); midbrain: 4.3 nTPM (vital, limit 1); parathyroid gland: 4.3 nTPM (protected, limit 3); pancreas: 4.1 nTPM (vital, limit 1); esophagus: 3.5 nTPM (protected, limit 3); adrenal gland: 3.5 nTPM (vital, limit 1); spinal cord: 3.2 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); smooth muscle: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FANK1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000203784,True,compatible,,True,True,True,,0.349908,0.3,0.249908,0,1,partial,0.4,0.1,0.3,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LELP1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000203795,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM24A,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000203857,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.234293,0,5,partial,8.4,0.4,4.3,"small intestine: 8.4 nTPM (vital, limit 3); adrenal gland: 1.2 nTPM (vital, limit 1)",adrenal gland / cells in zona fasciculata: Low (Supported); adrenal gland / cells in zona glomerulosa: Low (Supported); adrenal gland / glandular cells: Low (Supported),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HSD3B1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000203907,True,compatible,,True,True,True,,0.338776,0.240323,0.215035,0,4,partial,0.9,1.7,0.9,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OOEP,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1371/journal.pgen.1011734,Bruggeman 2018;Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000203909,True,compatible,,True,True,True,,0.302381,0.3,0.05,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DPPA5,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000203910,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.274051,0.273333,0.0349462,0,80,unavailable,2,0.2,0.6,"retina: 2 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C1orf146,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000203923,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPANXN1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000203926,True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPANXA2,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000203933,True,compatible,,True,True,True,,0.35,0.3,0.205882,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CXorf66,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000203942,True,compatible,,True,True,True,,0.35,0.29926,0.248153,0,5,partial,0.8,0.2,0.1,,,51,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C10orf62,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000203963,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293333,0.0777778,0,80,unavailable,3.1,0.1,0,"retina: 3.1 nTPM (vital, limit 1); choroid plexus: 2.7 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C1orf141,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000203970,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,DEFB110,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000203989,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RHOXF2B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000203995,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 56.9231% (minimum 75%, Missing); thyroid gland: 62.7119% (minimum 65%, Missing)",-0.0228814,0.160465,-0.180769,0,80,unavailable,2.8,0.6,2.2,"kidney: 2.8 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZYG11A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000204006,True,compatible,,True,True,True,,0.345968,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C1orf185,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000204007,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GLT6D1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000204019,True,compatible,,True,True,True,,0.35,0.259877,0.25,0,80,unavailable,0,2.6,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT83,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,True,True,True,gained,grid_revised
ENSG00000204022,True,compatible,,True,True,True,,0.281507,0.257746,0.181507,0,80,unavailable,0.5,0.3,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LIPJ,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000204025,True,compatible,,True,True,True,,0.35,0.3,0.240521,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRPC5OS,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000204052,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.290783,0.0247748,0,12,partial,12.5,3.5,1,"cerebral cortex: 12.5 nTPM (vital, limit 1); basal ganglia: 9.8 nTPM (vital, limit 1); hippocampal formation: 8.4 nTPM (vital, limit 1); amygdala: 7.1 nTPM (vital, limit 1); adrenal gland: 6.2 nTPM (vital, limit 6); choroid plexus: 6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1)",bronchus / ciliated cells (ciliary rootlets): High (Enhanced); caudate / glial cells: Low (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Low (Enhanced); cerebellum / synaptic glomeruli - core: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); rectum / glandular cells: Low (Enhanced),69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRRC73,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000204086,False,excluded,positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.15,0.188889,0.05,0,2,partial,0.4,0.2,0.4,,adipose tissue / adipocytes: Low (Approved); adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: High (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: High (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RPA4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000204140,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.173553,0,1,partial,173.3,1.5,0.1,"pancreas: 173.3 nTPM (vital, limit 6); hippocampal formation: 2.8 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1)",,52,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CLPSL1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204165,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.258333,0.290909,0.201965,0,80,unavailable,1.1,0.2,2.2,"small intestine: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CXorf65,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000204193,True,compatible,,True,True,True,,0.345327,0.3,0.25,0,80,unavailable,0,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TXNDC8,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000204246,False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR13C3,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204279,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PAGE3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000204296,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0.2,0.1,,,54,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TSBP1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000204300,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TMEM225,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000204311,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.21645,0.20785,0.0609756,0,80,unavailable,6.2,2.7,4.1,"retina: 6.2 nTPM (vital, limit 1); pituitary gland: 5.7 nTPM (vital, limit 1); choroid plexus: 5.2 nTPM (vital, limit 1); basal ganglia: 4.4 nTPM (vital, limit 1); midbrain: 4.3 nTPM (vital, limit 1); kidney: 4.1 nTPM (vital, limit 1); liver: 4 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); hippocampal formation: 3.7 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); skeletal muscle: 3.3 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); bone marrow: 1.4 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PJVK,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000204334,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.288751,0.261979,0.023411,0,80,unavailable,46.7,6.3,10.4,"choroid plexus: 46.7 nTPM (vital, limit 1); thyroid gland: 10.4 nTPM (manageable, limit 5); lung: 9.3 nTPM (vital, limit 1); parathyroid gland: 6.3 nTPM (protected, limit 3); retina: 5.5 nTPM (vital, limit 1); hypothalamus: 4.4 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.9 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); midbrain: 3.7 nTPM (vital, limit 1); kidney: 3.7 nTPM (vital, limit 1); basal ganglia: 3.4 nTPM (vital, limit 1); liver: 3.3 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); adrenal gland: 2.2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ERICH2,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,False,False,False,False,unchanged,
ENSG00000204363,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPANXN5,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000204379,True,compatible,,True,True,True,,0.347817,0.297817,0.247817,0,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,XAGE1A,current_adaptive,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000204382,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.338827,0.290672,0.222527,0,80,unavailable,1.5,0.5,0.6,"liver: 1.5 nTPM (vital, limit 1); lung: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,XAGE1B,current_adaptive,True,False,False,False,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Seager 2024 · panel;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204390,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.35,0.298374,0.200464,0,4,partial,3.8,1.7,2.4,"basal ganglia: 3.2 nTPM (vital, limit 1); spinal cord: 3 nTPM (vital, limit 1); amygdala: 2.9 nTPM (vital, limit 1); midbrain: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced),65,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HSPA1L,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000204414,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.348625,0.3,0.244524,0,3,partial,0.8,0.3,0.2,,pituitary gland / cells in anterior : High (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CSHL1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics",False,False,False,False,False,unchanged,
ENSG00000204449,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TRIM49C,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204478,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRAMEF20,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000204480,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,PRAMEF19,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204481,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRAMEF14,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204501,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,PRAMEF15,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204505,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 44.4444% (minimum 70%, Missing); heart muscle: 40.0000% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); retina: 57.1429% (minimum 75%, Missing); skeletal muscle: 1.2308% (minimum 75%, Missing); skin: 57.1429% (minimum 65%, Missing); thyroid gland: 57.1429% (minimum 65%, Missing)",-0.0785714,-0.255556,-0.737692,0,80,unavailable,32.1,0.5,0.3,"skeletal muscle: 32.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRAMEF9,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204524,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 58.3333% (minimum 65%, Uncertain); adrenal gland: 52.5000% (minimum 75%, Missing); bone marrow: 24.1379% (minimum 75%, Missing); cerebral cortex: 65.6250% (minimum 75%, Missing); choroid plexus: 60.0000% (minimum 75%, Missing); colon: 63.6364% (minimum 70%, Missing); duodenum: 67.7419% (minimum 75%, Missing); esophagus: 65.6250% (minimum 70%, Missing); heart muscle: 58.3333% (minimum 75%, Missing); kidney: 61.7647% (minimum 75%, Missing); liver: 52.5000% (minimum 75%, Missing); lung: 58.3333% (minimum 75%, Missing); lymph node: 58.3333% (minimum 70%, Missing); pancreas: 61.7647% (minimum 75%, Missing); parathyroid gland: 50.0000% (minimum 70%, Missing); pituitary gland: 61.7647% (minimum 75%, Missing); rectum: 58.3333% (minimum 70%, Missing); retina: 44.6809% (minimum 75%, Missing); salivary gland: 60.0000% (minimum 70%, Missing); skeletal muscle: 55.2632% (minimum 75%, Missing); skin: 52.5000% (minimum 65%, Missing); small intestine: 65.6250% (minimum 75%, Missing); smooth muscle: 55.2632% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 58.3333% (minimum 70%, Missing); thymus: 56.7568% (minimum 65%, Missing); thyroid gland: 56.7568% (minimum 65%, Missing); tongue: 51.2195% (minimum 70%, Missing); urinary bladder: 61.7647% (minimum 70%, Missing)",-0.15,-0.2,-0.508621,0,7,partial,6.6,2.1,2.1,"bone marrow: 6.6 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); liver: 1.9 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1); small intestine: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / glial cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF805,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000204536,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.238816,0.195889,0.126135,0,80,unavailable,19.1,15.7,16.9,"kidney: 19.1 nTPM (vital, limit 1); skeletal muscle: 18.6 nTPM (vital, limit 1); skin: 16.9 nTPM (manageable, limit 5); cerebellum: 16.8 nTPM (vital, limit 1); colon: 15.7 nTPM (protected, limit 3); thyroid gland: 15.6 nTPM (manageable, limit 5); esophagus: 14.7 nTPM (protected, limit 3); small intestine: 14.3 nTPM (vital, limit 1); pancreas: 14.1 nTPM (vital, limit 1); stomach: 13.5 nTPM (protected, limit 3); spleen: 13 nTPM (manageable, limit 5); urinary bladder: 12.9 nTPM (protected, limit 3); liver: 11.9 nTPM (vital, limit 1); heart muscle: 11.3 nTPM (vital, limit 1); salivary gland: 11.1 nTPM (protected, limit 3); basal ganglia: 10.5 nTPM (vital, limit 1); cerebral cortex: 10.2 nTPM (vital, limit 1); adipose tissue: 10.1 nTPM (manageable, limit 5); hypothalamus: 9.6 nTPM (vital, limit 1); duodenum: 9.6 nTPM (vital, limit 1); amygdala: 9.3 nTPM (vital, limit 1); pituitary gland: 9 nTPM (vital, limit 1); hippocampal formation: 8.7 nTPM (vital, limit 1); lung: 8.7 nTPM (vital, limit 1); midbrain: 8.2 nTPM (vital, limit 1); adrenal gland: 7.3 nTPM (vital, limit 1); spinal cord: 7.2 nTPM (vital, limit 1); lymph node: 6.8 nTPM (protected, limit 3); rectum: 3.1 nTPM (protected, limit 3); smooth muscle: 1.5 nTPM (vital, limit 1); retina: 1.2 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCHCR1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000204540,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.320909,0.28615,0.233425,0,80,unavailable,1.8,1.5,3.2,"small intestine: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); cerebral cortex: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PSORS1C1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000204548,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,51,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,DEFB121,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204614,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 41.1765% (minimum 70%, Missing); liver: 48.2759% (minimum 75%, Missing); small intestine: 32.5581% (minimum 75%, Missing)",0.35,-0.288235,-0.424419,0,80,unavailable,2.9,2,0,"small intestine: 2.9 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review,appendix,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRIM40,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000204640,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"hypothalamus: 27.2727% (minimum 75%, Missing); spinal cord: 42.8571% (minimum 75%, Missing)",0.35,0.05,-0.477273,0,80,unavailable,0.8,0.1,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,NMS,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204659,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.311538,0.261538,0.0833333,0,80,unavailable,3,0.6,0.6,"spinal cord: 3 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CBY3,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,False,False,False,False,unchanged,
ENSG00000204661,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA31J1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204669,True,compatible,,True,True,True,,0.35,0.3,0.242188,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C9orf57,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000204671,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IL31,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000204688,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR2H1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000204694,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR11A1,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204695,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 75.0000% (minimum 75%, Missing); bone marrow: 40.0000% (minimum 75%, Missing); cerebral cortex: 75.0000% (minimum 75%, Missing); duodenum: 75.0000% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); liver: 54.5455% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); retina: 25.0000% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 60.0000% (minimum 75%, Missing); skin: 46.1538% (minimum 65%, Missing); small intestine: 60.0000% (minimum 75%, Missing); spleen: 60.0000% (minimum 65%, Missing); stomach: 66.6667% (minimum 70%, Missing)",-0.188462,-0.0333333,-0.5,0,80,unavailable,1.8,0.3,0.7,"retina: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR14J1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204700,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing)",0.15,0.3,-0.0833333,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR2J2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204701,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 75.0000% (minimum 75%, Missing)",0.35,0.3,-1.11022e-16,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR2J3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204704,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR2W1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204764,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.0000% (minimum 75%, Missing); lung: 65.0000% (minimum 75%, Missing); pancreas: 50.0000% (minimum 75%, Missing); parathyroid gland: 61.9048% (minimum 70%, Missing); retina: 61.9048% (minimum 75%, Missing); salivary gland: 61.9048% (minimum 70%, Missing); thyroid gland: 56.5217% (minimum 65%, Missing)",-0.0847826,-0.0809524,-0.25,0,80,unavailable,1.3,0.8,1,"pancreas: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RANBP17,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000204849,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA31A1,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000204897,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 2.3339% (minimum 65%, Missing)",-0.626661,0.3,0.212963,0,4,partial,0.1,0.2,108.8,"skin: 108.8 nTPM (manageable, limit 5)",,71,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,hair / cells in internal root sheath; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KRT25,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204918,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,PRR20B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204919,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,PRR20A,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204930,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.319388,0.25,0.172358,0,5,partial,2.8,0.5,0.3,,kidney / cells in tubules: Low (Enhanced); lung / alveolar cells: Low (Enhanced); parathyroid gland / glandular cells: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); stomach 2 / glandular cells: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM221B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204941,True,compatible,,True,True,True,,0.35,0.3,0.247245,0,2,partial,0.8,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PSG5,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",True,True,True,True,True,unchanged,
ENSG00000204947,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.7273% (minimum 75%, Missing); amygdala: 56.1404% (minimum 75%, Missing); basal ganglia: 54.2373% (minimum 75%, Missing); cerebellum: 48.4848% (minimum 75%, Missing); cerebral cortex: 48.4848% (minimum 75%, Missing); choroid plexus: 68.0851% (minimum 75%, Missing); colon: 61.5385% (minimum 70%, Missing); esophagus: 60.3774% (minimum 70%, Missing); hippocampal formation: 58.1818% (minimum 75%, Missing); hypothalamus: 58.1818% (minimum 75%, Missing); kidney: 59.2593% (minimum 75%, Missing); midbrain: 61.5385% (minimum 75%, Missing); pancreas: 69.5652% (minimum 75%, Missing); parathyroid gland: 58.1818% (minimum 70%, Missing); pituitary gland: 69.5652% (minimum 75%, Missing); retina: 71.1111% (minimum 75%, Missing); salivary gland: 65.3061% (minimum 70%, Missing); skeletal muscle: 47.0588% (minimum 75%, Missing); skin: 57.1429% (minimum 65%, Missing); smooth muscle: 65.3061% (minimum 75%, Missing); spinal cord: 62.7451% (minimum 75%, Missing); stomach: 68.0851% (minimum 70%, Missing); thyroid gland: 62.7451% (minimum 65%, Missing); tongue: 64.0000% (minimum 70%, Missing); urinary bladder: 64.0000% (minimum 70%, Missing)",-0.0785714,-0.118182,-0.279412,0,80,unavailable,3.6,2.3,2.4,"skeletal muscle: 3.6 nTPM (vital, limit 1); cerebellum: 3.4 nTPM (vital, limit 1); cerebral cortex: 3.4 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); hypothalamus: 2.3 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); smooth muscle: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF425,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000204952,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FBXO47,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000204956,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 58.8235% (minimum 75%, Missing); basal ganglia: 40.0000% (minimum 75%, Missing); cerebellum: 43.4783% (minimum 75%, Missing); cerebral cortex: 35.7143% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); heart muscle: 45.4545% (minimum 75%, Missing); hippocampal formation: 55.5556% (minimum 75%, Missing); hypothalamus: 62.5000% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 66.6667% (minimum 70%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); retina: 47.6190% (minimum 75%, Missing); skeletal muscle: 62.5000% (minimum 75%, Missing); smooth muscle: 71.4286% (minimum 75%, Missing); spinal cord: 71.4286% (minimum 75%, Missing)",0.119231,-0.0333333,-0.392857,0,80,unavailable,1.8,0.5,0.3,"cerebral cortex: 1.8 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); cerebellum: 1.3 nTPM (vital, limit 1); heart muscle: 1.2 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHGA1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000204961,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 57.8947% (minimum 75%, Missing); cerebral cortex: 73.3333% (minimum 75%, Missing); pancreas: 61.1111% (minimum 75%, Missing); spinal cord: 73.3333% (minimum 75%, Missing)",0.266667,0.3,-0.171053,0,80,unavailable,0.8,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHA9,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000204962,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 75.0000% (minimum 75%, Missing); amygdala: 50.0000% (minimum 75%, Missing); basal ganglia: 60.0000% (minimum 75%, Missing); cerebellum: 14.2857% (minimum 75%, Missing); cerebral cortex: 37.5000% (minimum 75%, Missing); hippocampal formation: 50.0000% (minimum 75%, Missing); hypothalamus: 50.0000% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); midbrain: 60.0000% (minimum 75%, Missing); pancreas: 75.0000% (minimum 75%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); retina: 37.5000% (minimum 75%, Missing); spinal cord: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.607143,0,80,unavailable,1.8,0,0,"cerebellum: 1.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHA8,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000204963,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 72.7273% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebellum: 32.0000% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); hippocampal formation: 61.5385% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); kidney: 72.7273% (minimum 75%, Missing); midbrain: 61.5385% (minimum 75%, Missing); pancreas: 72.7273% (minimum 75%, Missing); pituitary gland: 66.6667% (minimum 75%, Missing); retina: 66.6667% (minimum 75%, Missing); spinal cord: 40.0000% (minimum 75%, Missing)",0.15,0.1,-0.43,0,80,unavailable,1.7,0.2,0.2,"cerebellum: 1.7 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHA7,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204965,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 27.2727% (minimum 75%, Missing); basal ganglia: 37.5000% (minimum 75%, Missing); cerebellum: 9.6774% (minimum 75%, Missing); cerebral cortex: 12.5000% (minimum 75%, Missing); hippocampal formation: 30.0000% (minimum 75%, Missing); hypothalamus: 30.0000% (minimum 75%, Missing); midbrain: 37.5000% (minimum 75%, Missing); pancreas: 60.0000% (minimum 70%, Approved); pituitary gland: 37.5000% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); spinal cord: 42.8571% (minimum 75%, Missing)",0.15,0.1,-0.653226,0,0,routine_complete,2.8,0.1,0.1,"cerebellum: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1)",caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved),55,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHA5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000204967,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 38.4615% (minimum 75%, Missing); basal ganglia: 33.3333% (minimum 75%, Missing); bone marrow: 38.4615% (minimum 70%, Approved); cerebellum: 22.7273% (minimum 75%, Missing); cerebral cortex: 20.0000% (minimum 75%, Missing); duodenum: 71.4286% (minimum 75%, Missing); hippocampal formation: 38.4615% (minimum 75%, Missing); hypothalamus: 35.7143% (minimum 75%, Missing); kidney: 55.5556% (minimum 75%, Missing); lung: 55.5556% (minimum 70%, Approved); lymph node: 62.5000% (minimum 65%, Approved); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 29.4118% (minimum 75%, Missing); pituitary gland: 62.5000% (minimum 75%, Missing); retina: 38.4615% (minimum 75%, Missing); skin: 55.5556% (minimum 60%, Approved); small intestine: 71.4286% (minimum 75%, Missing); smooth muscle: 62.5000% (minimum 70%, Approved); spinal cord: 50.0000% (minimum 75%, Missing)",-0.0444444,-0.025,-0.55,0,3,partial,2,0.3,0.4,"cerebral cortex: 2 nTPM (vital, limit 1); cerebellum: 1.7 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 2 / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHA4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000204969,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 53.3333% (minimum 75%, Missing); basal ganglia: 57.1429% (minimum 75%, Missing); cerebellum: 25.0000% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); hippocampal formation: 53.3333% (minimum 75%, Missing); hypothalamus: 57.1429% (minimum 75%, Missing); kidney: 72.7273% (minimum 75%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 72.7273% (minimum 75%, Missing); pituitary gland: 32.0000% (minimum 75%, Missing); retina: 61.5385% (minimum 75%, Missing); spinal cord: 61.5385% (minimum 75%, Missing)",0.238889,0.1,-0.5,0,80,unavailable,2.4,0.2,0.1,"cerebellum: 2.4 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHA2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204970,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 40.0000% (minimum 75%, Missing); basal ganglia: 32.2581% (minimum 75%, Missing); cerebellum: 30.3030% (minimum 60%, Enhanced); cerebral cortex: 31.2500% (minimum 75%, Missing); hippocampal formation: 35.7143% (minimum 75%, Missing); hypothalamus: 35.7143% (minimum 75%, Missing); midbrain: 41.6667% (minimum 75%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); spinal cord: 26.3158% (minimum 75%, Missing)",0.35,0.3,-0.486842,0,1,partial,2.8,0.1,0,"spinal cord: 2.8 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); basal ganglia: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); hypothalamus: 1.8 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHA1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000204979,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MS4A13,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000205078,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.223563,0.123105,0.130309,0,80,unavailable,3.1,4.9,3.3,"salivary gland: 4.9 nTPM (protected, limit 3); kidney: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); amygdala: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); spinal cord: 2.2 nTPM (vital, limit 1); pituitary gland: 2.1 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); heart muscle: 1.3 nTPM (vital, limit 1); bone marrow: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SYCE1L,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000205085,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347183,0.3,0.141688,0,1,partial,4.3,2.3,2.6,"pituitary gland: 4.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1)",,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GARIN1A,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000205108,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA31F1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000205111,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 74.0741% (minimum 75%, Missing)",0.302381,0.252381,-0.00925926,0,80,unavailable,0.7,0.1,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CDKL4,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000205129,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 71.6049% (minimum 75%, Missing); choroid plexus: 27.3585% (minimum 75%, Missing); retina: 46.9636% (minimum 75%, Missing)",0.238854,0.291453,-0.476415,0,4,partial,30.8,0.5,4.1,"choroid plexus: 30.8 nTPM (vital, limit 1); retina: 13.1 nTPM (vital, limit 1); basal ganglia: 4.6 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); hippocampal formation: 2.9 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); amygdala: 2 nTPM (vital, limit 1); spinal cord: 1.6 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); nasopharynx / ciliated cells (cilia axoneme): High (Enhanced); nasopharynx / ciliated cells (tip of cilia): High (Enhanced); skeletal muscle / myocytes: Low (Enhanced),64,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP96,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000205133,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.5769% (minimum 65%, Missing); adrenal gland: 47.1322% (minimum 75%, Missing); amygdala: 60.5769% (minimum 75%, Missing); basal ganglia: 56.0831% (minimum 75%, Missing); bone marrow: 56.9277% (minimum 75%, Missing); cerebellum: 54.6243% (minimum 75%, Missing); cerebral cortex: 51.7808% (minimum 75%, Missing); choroid plexus: 70.0000% (minimum 75%, Missing); colon: 48.5861% (minimum 70%, Missing); duodenum: 61.1650% (minimum 75%, Missing); esophagus: 66.5493% (minimum 70%, Missing); heart muscle: 49.3473% (minimum 75%, Missing); hippocampal formation: 61.7647% (minimum 75%, Missing); hypothalamus: 61.9672% (minimum 75%, Missing); kidney: 50.2660% (minimum 75%, Missing); liver: 38.3367% (minimum 75%, Missing); lung: 53.3898% (minimum 75%, Missing); midbrain: 62.3762% (minimum 75%, Missing); pancreas: 52.0661% (minimum 75%, Missing); parathyroid gland: 48.7113% (minimum 70%, Missing); pituitary gland: 64.5051% (minimum 75%, Missing); rectum: 48.2143% (minimum 70%, Missing); retina: 61.1650% (minimum 75%, Missing); salivary gland: 63.6364% (minimum 70%, Missing); small intestine: 61.5635% (minimum 75%, Missing); smooth muscle: 63.2107% (minimum 75%, Missing); spinal cord: 54.7826% (minimum 75%, Missing); spleen: 59.6215% (minimum 65%, Missing); stomach: 52.6462% (minimum 70%, Missing); thyroid gland: 45.4327% (minimum 65%, Missing); urinary bladder: 55.9172% (minimum 70%, Missing)",-0.195673,-0.217857,-0.366633,0,80,unavailable,30.4,20.3,22.7,"liver: 30.4 nTPM (vital, limit 1); thyroid gland: 22.7 nTPM (manageable, limit 5); adrenal gland: 21.2 nTPM (vital, limit 1); rectum: 20.3 nTPM (protected, limit 3); colon: 20 nTPM (protected, limit 3); parathyroid gland: 19.9 nTPM (protected, limit 3); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 18.7 nTPM (vital, limit 1); cerebral cortex: 17.6 nTPM (vital, limit 1); pancreas: 17.4 nTPM (vital, limit 1); stomach: 17 nTPM (protected, limit 3); lung: 16.5 nTPM (vital, limit 1); cerebellum: 15.7 nTPM (vital, limit 1); spinal cord: 15.6 nTPM (vital, limit 1); urinary bladder: 14.9 nTPM (protected, limit 3); basal ganglia: 14.8 nTPM (vital, limit 1); bone marrow: 14.3 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); adipose tissue: 12.3 nTPM (manageable, limit 5); amygdala: 12.3 nTPM (vital, limit 1); retina: 12 nTPM (vital, limit 1); duodenum: 12 nTPM (vital, limit 1); small intestine: 11.8 nTPM (vital, limit 1); hippocampal formation: 11.7 nTPM (vital, limit 1); hypothalamus: 11.6 nTPM (vital, limit 1); midbrain: 11.4 nTPM (vital, limit 1); smooth muscle: 11 nTPM (vital, limit 1); salivary gland: 10.8 nTPM (protected, limit 3); pituitary gland: 10.4 nTPM (vital, limit 1); esophagus: 9.5 nTPM (protected, limit 3); choroid plexus: 8.1 nTPM (vital, limit 1); thymus: 7.1 nTPM (manageable, limit 5); skin: 5.5 nTPM (manageable, limit 5); tongue: 5.4 nTPM (protected, limit 3); lymph node: 5.2 nTPM (protected, limit 3); skeletal muscle: 2.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRIQK,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000205177,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.0190647,0.0622951,0.111111,0,80,unavailable,1.5,2.9,4.6,"pancreas: 1.5 nTPM (vital, limit 1); kidney: 1.3 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C11orf91,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,False,False,False,False,unchanged,
ENSG00000205208,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 46.4419% (minimum 75%, Uncertain); lymph node: 67.7596% (minimum 70%, Missing); retina: 57.4074% (minimum 75%, Missing); thymus: 55.6054% (minimum 65%, Missing); tongue: 68.1319% (minimum 70%, Missing)",-0.0939462,-0.0224044,-0.285581,0,1,partial,14.3,5.9,9.9,"bone marrow: 14.3 nTPM (vital, limit 1); thymus: 9.9 nTPM (manageable, limit 5); retina: 9.2 nTPM (vital, limit 1); lymph node: 5.9 nTPM (protected, limit 3); tongue: 5.8 nTPM (protected, limit 3); rectum: 4 nTPM (protected, limit 3); smooth muscle: 3.9 nTPM (vital, limit 1); heart muscle: 3.5 nTPM (vital, limit 1); colon: 3.2 nTPM (protected, limit 3); duodenum: 2.9 nTPM (vital, limit 1); spinal cord: 2.7 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); lung: 2.5 nTPM (vital, limit 1); pancreas: 2.3 nTPM (vital, limit 1); cerebellum: 2.3 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); skeletal muscle: 2 nTPM (vital, limit 1); kidney: 1.9 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",bronchus / respiratory epithelial cells: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C4orf46,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000205301,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MGAT4D,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000205359,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLCO6A1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000205409,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR52E6,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · testis-biased",False,False,False,False,False,unchanged,
ENSG00000205442,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IZUMO3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000205445,False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,14.6,"skin: 14.6 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KRTAP10-2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000205456,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebellum: 68.7500% (minimum 75%, Missing)",0.306522,0.162745,-0.0625,0,80,unavailable,2,0.7,0.2,"cerebellum: 2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TP53TG3D,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,False,False,False,False,unchanged,
ENSG00000205457,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 75.0000% (minimum 75%, Missing); pancreas: 60.0000% (minimum 75%, Missing)",0.35,0.3,-0.15,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TP53TG3C,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000205639,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"basal ganglia: 71.4286% (minimum 75%, Missing); bone marrow: 4.0984% (minimum 75%, Missing); spleen: 62.5000% (minimum 65%, Missing)",-0.025,0.3,-0.709016,0,4,partial,11.7,0,0.3,"bone marrow: 11.7 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: High (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / Purkinje cells: Medium (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen; spleen / cells in red pulp; tonsil; tonsil / germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MFSD2B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000205642,True,compatible,,True,True,True,,0.342958,0.3,0.222414,0,7,partial,0.4,0,0.1,,,50,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,VCX3B,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000205649,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"bone marrow: 40.2556% (minimum 60%, Enhanced); heart muscle: 33.3333% (minimum 60%, Enhanced); pancreas: 9.5382% (minimum 60%, Enhanced); salivary gland: 0.0096% (minimum 70%, Missing)",0.0650224,-0.699904,-0.504618,0,1,partial,119.5,131918,9.7,"salivary gland: 131918 nTPM (protected, limit 3); pancreas: 119.5 nTPM (vital, limit 6); heart muscle: 25.2 nTPM (vital, limit 6); bone marrow: 18.7 nTPM (vital, limit 6); pituitary gland: 1.7 nTPM (vital, limit 1)",salivary gland / glandular cells: High (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HTN3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000205707,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 54.9296% (minimum 70%, Approved); amygdala: 63.1214% (minimum 75%, Missing); basal ganglia: 65.4676% (minimum 75%, Missing); cerebral cortex: 64.0094% (minimum 70%, Approved); duodenum: 62.6866% (minimum 70%, Approved); heart muscle: 51.6068% (minimum 75%, Missing); hippocampal formation: 63.5623% (minimum 75%, Missing); hypothalamus: 67.6580% (minimum 75%, Missing); kidney: 50.3690% (minimum 70%, Approved); liver: 31.7073% (minimum 70%, Approved); lung: 72.2222% (minimum 75%, Missing); midbrain: 58.5837% (minimum 75%, Missing); parathyroid gland: 60.2649% (minimum 65%, Approved); retina: 64.9227% (minimum 75%, Missing); salivary gland: 64.9227% (minimum 65%, Approved); skeletal muscle: 38.8612% (minimum 75%, Missing); spinal cord: 43.7150% (minimum 75%, Missing); stomach: 64.9227% (minimum 70%, Missing); thyroid gland: 56.5803% (minimum 60%, Approved); tongue: 35.8739% (minimum 70%, Missing)",-0.0341969,-0.341261,-0.382927,0,3,partial,117.6,97.6,41.9,"liver: 117.6 nTPM (vital, limit 2); tongue: 97.6 nTPM (protected, limit 3); skeletal muscle: 85.9 nTPM (vital, limit 1); spinal cord: 70.3 nTPM (vital, limit 1); kidney: 53.8 nTPM (vital, limit 2); heart muscle: 51.2 nTPM (vital, limit 1); adrenal gland: 44.8 nTPM (vital, limit 2); thyroid gland: 41.9 nTPM (manageable, limit 10); midbrain: 38.6 nTPM (vital, limit 1); parathyroid gland: 36 nTPM (protected, limit 4); duodenum: 32.5 nTPM (vital, limit 2); amygdala: 31.9 nTPM (vital, limit 1); hippocampal formation: 31.3 nTPM (vital, limit 1); cerebral cortex: 30.7 nTPM (vital, limit 2); stomach: 29.5 nTPM (protected, limit 3); salivary gland: 29.5 nTPM (protected, limit 4); retina: 29.5 nTPM (vital, limit 1); basal ganglia: 28.8 nTPM (vital, limit 1); adipose tissue: 27.2 nTPM (manageable, limit 10); hypothalamus: 26.1 nTPM (vital, limit 1); skin: 23.6 nTPM (manageable, limit 5); pancreas: 23.3 nTPM (vital, limit 2); small intestine: 23.2 nTPM (vital, limit 2); esophagus: 21.8 nTPM (protected, limit 3); lung: 21 nTPM (vital, limit 1); rectum: 18.8 nTPM (protected, limit 4); thymus: 18.4 nTPM (manageable, limit 5); spleen: 17.8 nTPM (manageable, limit 10); smooth muscle: 17.6 nTPM (vital, limit 2); lymph node: 17.5 nTPM (protected, limit 4); urinary bladder: 17.4 nTPM (protected, limit 4); colon: 17.3 nTPM (protected, limit 3); pituitary gland: 14.7 nTPM (vital, limit 1); choroid plexus: 13.6 nTPM (vital, limit 1); bone marrow: 12.8 nTPM (vital, limit 2); cerebellum: 10.1 nTPM (vital, limit 2)",colon / endothelial cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); lung / alveolar cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ETFRF1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000205718,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,MBD3L4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000205777,True,compatible,,True,True,True,,0.35,0.3,0.0326087,0,4,partial,0.5,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GAGE1,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,True,True,True,True,gained,selectivity_revised
ENSG00000205784,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.237097,0.206593,0.161602,0,80,unavailable,1.6,1.7,2.1,"bone marrow: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ARRDC5,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000205832,True,compatible,,True,True,True,,0.321429,0.290291,0.194444,0,80,unavailable,0.6,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C16orf96,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000205835,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 72.8972% (minimum 75%, Missing); liver: 66.1017% (minimum 75%, Missing)",0.35,0.3,-0.0889831,0,80,unavailable,4,0,0,"liver: 4 nTPM (vital, limit 1); choroid plexus: 2.9 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GMNC,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000205838,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.340654,0.3,0.188053,0,2,partial,1.4,0.8,0.9,"retina: 1.4 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TTC23L,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000205856,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"hypothalamus: 52.5510% (minimum 75%, Missing)",0.35,0.3,-0.22449,0,3,partial,9.3,0.3,0,"hypothalamus: 9.3 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C22orf42,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000205858,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRRC72,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000205882,True,compatible,,True,True,True,,0.35,0.287903,0.23,0,80,unavailable,0.5,0.3,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DEFB134,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000205883,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.248195,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,DEFB135,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000205916,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 30.7692% (minimum 65%, Approved)",0.35,-0.342308,0.25,0,1,partial,0.1,25.2,0.4,"stomach: 25.2 nTPM (protected, limit 4)",,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DAZ4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000205944,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 35.8025% (minimum 65%, Approved)",0.335484,-0.291975,0.25,0,1,partial,0,5.2,0.2,"stomach: 5.2 nTPM (protected, limit 4)",,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DAZ2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000206026,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SMIM21,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000206043,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C18orf63,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000206052,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"amygdala: 25.9091% (minimum 75%, Missing); basal ganglia: 44.8819% (minimum 75%, Missing); cerebellum: 52.7778% (minimum 75%, Missing); cerebral cortex: 24.3590% (minimum 75%, Missing); heart muscle: 48.7179% (minimum 75%, Missing); hippocampal formation: 30.1587% (minimum 75%, Missing); hypothalamus: 44.5312% (minimum 75%, Missing); kidney: 54.8077% (minimum 75%, Missing); lung: 71.2500% (minimum 75%, Missing); midbrain: 38.2550% (minimum 75%, Missing); parathyroid gland: 32.0225% (minimum 65%, Approved); retina: 20.8791% (minimum 75%, Missing)",0.121519,-0.329775,-0.541209,0,0,routine_complete,21.6,12.1,2.2,"retina: 21.6 nTPM (vital, limit 1); cerebral cortex: 17.7 nTPM (vital, limit 1); amygdala: 16.3 nTPM (vital, limit 1); hippocampal formation: 13.2 nTPM (vital, limit 1); parathyroid gland: 12.1 nTPM (protected, limit 4); midbrain: 9.2 nTPM (vital, limit 1); hypothalamus: 7.1 nTPM (vital, limit 1); basal ganglia: 7 nTPM (vital, limit 1); heart muscle: 6 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); kidney: 4.7 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 2); liver: 2.3 nTPM (vital, limit 2); lung: 2.3 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in white pulp: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / keratinocytes; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DOK6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000206102,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing)",0.15,0.3,-0.0833333,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,KRTAP19-8,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000206113,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"choroid plexus: 67.1053% (minimum 75%, Missing)",0.312264,0.280769,-0.0789474,0,80,unavailable,2.5,0.1,0.2,"choroid plexus: 2.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP99,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,False,False,False,False,unchanged,
ENSG00000206150,True,compatible,,True,True,True,,0.348334,0.290413,0.247337,0,80,unavailable,0.8,2.9,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RNASE13,current_adaptive,True,False,True,False,10.1038/ncomms10499,Wang 2016,False,False,True,True,True,gained,grid_revised
ENSG00000206181,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,gallbladder / glandular cells; lymph node / germinal center cells; skin 2 / epidermal cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ELOA2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000206203,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.349244,0.3,0.246229,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,appendix; skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TSSK2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000206260,True,compatible,,True,True,True,,0.35,0.3,0.1875,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRR23A,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000206530,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"cerebellum: 70.9677% (minimum 75%, Uncertain); choroid plexus: 52.8000% (minimum 75%, Missing); lung: 73.3333% (minimum 75%, Uncertain); pancreas: 64.7059% (minimum 75%, Uncertain); pituitary gland: 51.9685% (minimum 75%, Missing); retina: 44.0000% (minimum 75%, Missing); salivary gland: 57.8947% (minimum 70%, Uncertain); small intestine: 70.2128% (minimum 75%, Uncertain); stomach: 69.4737% (minimum 70%, Uncertain)",0.0304124,-0.121053,-0.31,0,1,partial,8.4,4.8,3.1,"retina: 8.4 nTPM (vital, limit 1); pituitary gland: 6.1 nTPM (vital, limit 1); choroid plexus: 5.9 nTPM (vital, limit 1); salivary gland: 4.8 nTPM (protected, limit 3); pancreas: 3.6 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); liver: 2 nTPM (vital, limit 1); kidney: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); hypothalamus: 1.3 nTPM (vital, limit 1); skeletal muscle: 1.3 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",cerebral cortex / neuronal cells: Low (Uncertain); skin 2 / epidermal cells: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP44,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000206531,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CD200R1L,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000206557,True,compatible,,True,True,True,,0.35,0.3,0.104545,0,80,unavailable,0.8,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRIM71,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000212122,True,compatible,,True,True,True,,0.35,0.3,0.248084,0,1,partial,0.1,0,0.2,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TSSK1B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000212123,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333838,0.227619,0.138686,0,5,partial,11.6,4.9,6.3,"liver: 11.6 nTPM (vital, limit 6); kidney: 6.9 nTPM (vital, limit 6); pancreas: 6.1 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); pituitary gland: 3.7 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); spinal cord: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRR22,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000212710,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CTAGE1,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000212916,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"basal ganglia: 68.4211% (minimum 75%, Missing); cerebral cortex: 55.3191% (minimum 75%, Missing); duodenum: 70.2703% (minimum 75%, Missing); heart muscle: 55.3191% (minimum 75%, Missing); hypothalamus: 74.2857% (minimum 75%, Missing); kidney: 74.2857% (minimum 75%, Missing); liver: 54.1667% (minimum 70%, Approved); lung: 72.2222% (minimum 75%, Missing); lymph node: 54.1667% (minimum 70%, Missing); pancreas: 60.4651% (minimum 75%, Missing); retina: 48.1481% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 55.3191% (minimum 75%, Missing); small intestine: 63.4146% (minimum 75%, Missing); smooth muscle: 72.2222% (minimum 75%, Missing); stomach: 66.6667% (minimum 70%, Missing); thymus: 45.6140% (minimum 65%, Missing); thyroid gland: 59.0909% (minimum 65%, Missing); tongue: 68.4211% (minimum 70%, Missing)",-0.19386,-0.158333,-0.268519,0,2,partial,2.8,2.2,3.1,"retina: 2.8 nTPM (vital, limit 1); liver: 2.2 nTPM (vital, limit 2); cerebral cortex: 2.1 nTPM (vital, limit 1); heart muscle: 2.1 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); pancreas: 1.7 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); basal ganglia: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: High (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); kidney / cells in tubules: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: High (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: High (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / chondrocytes: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); stomach 1 / glandular cells: High (Approved); stomach 2 / glandular cells: High (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAP10,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000212933,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0.5,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,KRTAP12-4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000213020,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 72.0430% (minimum 75%, Missing); bone marrow: 66.3366% (minimum 75%, Missing); cerebellum: 72.0430% (minimum 75%, Missing); cerebral cortex: 70.5263% (minimum 75%, Missing); duodenum: 74.4444% (minimum 75%, Missing); heart muscle: 70.5263% (minimum 75%, Missing); kidney: 63.8095% (minimum 75%, Missing); lung: 69.7917% (minimum 75%, Missing); lymph node: 66.3366% (minimum 70%, Missing); pancreas: 62.0370% (minimum 75%, Missing); rectum: 69.0722% (minimum 70%, Missing); retina: 62.0370% (minimum 75%, Missing); smooth muscle: 68.3673% (minimum 75%, Missing); thymus: 61.4679% (minimum 65%, Missing); thyroid gland: 63.8095% (minimum 65%, Missing)",-0.0353211,-0.0366337,-0.12963,0,80,unavailable,4.1,3.4,4.2,"retina: 4.1 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); kidney: 3.8 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); bone marrow: 3.4 nTPM (vital, limit 1); smooth muscle: 3.1 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); heart muscle: 2.8 nTPM (vital, limit 1); basal ganglia: 2.6 nTPM (vital, limit 1); cerebellum: 2.6 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); small intestine: 1.9 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF611,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000213024,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 62.7297% (minimum 75%, Missing); bone marrow: 64.8575% (minimum 75%, Missing); cerebellum: 62.9776% (minimum 75%, Missing); colon: 68.7770% (minimum 70%, Missing); duodenum: 67.7054% (minimum 75%, Missing); esophagus: 66.3889% (minimum 70%, Missing); heart muscle: 70.8148% (minimum 75%, Missing); kidney: 72.7549% (minimum 75%, Missing); liver: 60.7370% (minimum 75%, Missing); lung: 72.0965% (minimum 75%, Missing); lymph node: 56.1692% (minimum 70%, Missing); pancreas: 70.1909% (minimum 75%, Missing); pituitary gland: 68.2857% (minimum 75%, Missing); salivary gland: 69.3759% (minimum 70%, Missing); skeletal muscle: 59.6010% (minimum 75%, Missing); small intestine: 66.9468% (minimum 75%, Missing); smooth muscle: 64.2473% (minimum 75%, Missing); spleen: 62.4837% (minimum 65%, Missing); thymus: 54.6286% (minimum 65%, Missing); tongue: 69.6793% (minimum 70%, Missing); urinary bladder: 67.1348% (minimum 70%, Missing)",-0.103714,-0.138308,-0.15399,0,6,partial,32.4,37.3,39.7,"thymus: 39.7 nTPM (manageable, limit 5); lymph node: 37.3 nTPM (protected, limit 3); skeletal muscle: 32.4 nTPM (vital, limit 1); liver: 30.9 nTPM (vital, limit 1); spleen: 28.7 nTPM (manageable, limit 5); adrenal gland: 28.4 nTPM (vital, limit 1); cerebellum: 28.1 nTPM (vital, limit 1); smooth muscle: 26.6 nTPM (vital, limit 1); bone marrow: 25.9 nTPM (vital, limit 1); esophagus: 24.2 nTPM (protected, limit 3); small intestine: 23.6 nTPM (vital, limit 1); urinary bladder: 23.4 nTPM (protected, limit 3); duodenum: 22.8 nTPM (vital, limit 1); skin: 22.5 nTPM (manageable, limit 5); pituitary gland: 22.2 nTPM (vital, limit 1); colon: 21.7 nTPM (protected, limit 3); salivary gland: 21.1 nTPM (protected, limit 3); tongue: 20.8 nTPM (protected, limit 3); pancreas: 20.3 nTPM (vital, limit 1); rectum: 19.8 nTPM (protected, limit 3); heart muscle: 19.7 nTPM (vital, limit 1); adipose tissue: 19.2 nTPM (manageable, limit 5); stomach: 18.8 nTPM (protected, limit 3); lung: 18.5 nTPM (vital, limit 1); kidney: 17.9 nTPM (vital, limit 1); parathyroid gland: 17.1 nTPM (protected, limit 3); thyroid gland: 15.8 nTPM (manageable, limit 5); hypothalamus: 14.7 nTPM (vital, limit 1); spinal cord: 14.3 nTPM (vital, limit 1); cerebral cortex: 14.3 nTPM (vital, limit 1); hippocampal formation: 12.7 nTPM (vital, limit 1); basal ganglia: 12.6 nTPM (vital, limit 1); amygdala: 12.4 nTPM (vital, limit 1); midbrain: 12.3 nTPM (vital, limit 1); choroid plexus: 11.5 nTPM (vital, limit 1); retina: 9.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Supported); adrenal gland / glandular cells: Low (Supported); bone marrow / hematopoietic cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); bronchus / ciliated cells (ciliary rootlets): Low (Supported); bronchus / ciliated cells (tip of cilia): Low (Supported); caudate / glial cells: Low (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Low (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: Low (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Low (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Low (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Low (Supported); lung / alveolar cells type II: Low (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / ciliated cells (cell body): Medium (Supported); oral mucosa / squamous epithelial cells: Low (Supported); pancreas / exocrine glandular cells: Medium (Supported); pancreas / pancreatic endocrine cells: Low (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / fibroblasts: Low (Supported); skin 1 / keratinocytes: Low (Supported); skin 1 / Langerhans: Low (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 1 / peripheral nerve: Low (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Medium (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),66,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NUP62,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000213030,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.137255,0,1,partial,2.3,0,0,"pituitary gland: 2.3 nTPM (vital, limit 1)",,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CGB8,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased",False,False,False,False,False,unchanged,
ENSG00000213145,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 44.0175% (minimum 65%, Missing); colon: 60.8145% (minimum 70%, Missing); duodenum: 63.0788% (minimum 75%, Missing); esophagus: 63.5962% (minimum 65%, Approved); heart muscle: 44.2591% (minimum 70%, Approved); kidney: 65.4333% (minimum 75%, Missing); lung: 44.9599% (minimum 75%, Missing); salivary gland: 60.5042% (minimum 65%, Approved); skin: 40.8593% (minimum 65%, Missing); small intestine: 39.9129% (minimum 75%, Missing); stomach: 68.7585% (minimum 70%, Missing); thyroid gland: 53.3051% (minimum 65%, Missing); urinary bladder: 64.6983% (minimum 65%, Approved)",-0.241407,-0.0918552,-0.350871,0,7,partial,303.5,131.6,291.8,"small intestine: 303.5 nTPM (vital, limit 1); skin: 291.8 nTPM (manageable, limit 5); adipose tissue: 256.4 nTPM (manageable, limit 5); heart muscle: 253.9 nTPM (vital, limit 2); lung: 246.8 nTPM (vital, limit 1); thyroid gland: 176.6 nTPM (manageable, limit 5); salivary gland: 131.6 nTPM (protected, limit 4); colon: 129.9 nTPM (protected, limit 3); duodenum: 118 nTPM (vital, limit 1); esophagus: 115.4 nTPM (protected, limit 4); urinary bladder: 110 nTPM (protected, limit 4); kidney: 106.5 nTPM (vital, limit 1); spleen: 92.2 nTPM (manageable, limit 5); stomach: 91.6 nTPM (protected, limit 3); lymph node: 81.8 nTPM (protected, limit 3); thymus: 77.5 nTPM (manageable, limit 5); rectum: 53.5 nTPM (protected, limit 3); tongue: 48.1 nTPM (protected, limit 3); choroid plexus: 44.8 nTPM (vital, limit 1); skeletal muscle: 43.2 nTPM (vital, limit 2); smooth muscle: 40.8 nTPM (vital, limit 1); pituitary gland: 40.4 nTPM (vital, limit 1); midbrain: 30.6 nTPM (vital, limit 1); basal ganglia: 29.7 nTPM (vital, limit 1); hypothalamus: 29.2 nTPM (vital, limit 1); bone marrow: 29 nTPM (vital, limit 2); hippocampal formation: 28 nTPM (vital, limit 1); amygdala: 24.8 nTPM (vital, limit 1); spinal cord: 21.9 nTPM (vital, limit 1); adrenal gland: 21 nTPM (vital, limit 2); parathyroid gland: 20.5 nTPM (protected, limit 4); pancreas: 17.7 nTPM (vital, limit 2); liver: 17.4 nTPM (vital, limit 2); cerebral cortex: 15.5 nTPM (vital, limit 1); cerebellum: 7.3 nTPM (vital, limit 2)",adipose tissue / adipocytes: Medium (Approved); bronchus / ciliated cells (cell body): High (Approved); bronchus / goblet cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Low (Approved); lung / macrophages: High (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: Medium (Approved); skin 1 / fibroblasts: High (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: High (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Low (Approved); soft tissue 1 / fibroblasts: Medium (Approved); spleen / cells in white pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved),61,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CRIP1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000213186,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 62.6866% (minimum 75%, Missing); basal ganglia: 56.7568% (minimum 75%, Missing); bone marrow: 33.0709% (minimum 75%, Missing); cerebral cortex: 44.6809% (minimum 75%, Missing); esophagus: 64.1221% (minimum 70%, Missing); hippocampal formation: 48.8372% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); lymph node: 41.5842% (minimum 70%, Missing); midbrain: 48.2759% (minimum 75%, Missing); skin: 61.3139% (minimum 65%, Missing); spinal cord: 45.6522% (minimum 75%, Missing); spleen: 62.6866% (minimum 65%, Missing); thymus: 38.7097% (minimum 65%, Missing)",-0.262903,-0.284158,-0.419291,0,80,unavailable,17,11.8,13.3,"bone marrow: 17 nTPM (vital, limit 1); thymus: 13.3 nTPM (manageable, limit 5); lymph node: 11.8 nTPM (protected, limit 3); cerebral cortex: 10.4 nTPM (vital, limit 1); spinal cord: 10 nTPM (vital, limit 1); midbrain: 9 nTPM (vital, limit 1); hippocampal formation: 8.8 nTPM (vital, limit 1); basal ganglia: 6.4 nTPM (vital, limit 1); skin: 5.3 nTPM (manageable, limit 5); amygdala: 5 nTPM (vital, limit 1); esophagus: 4.7 nTPM (protected, limit 3); hypothalamus: 4.2 nTPM (vital, limit 1); small intestine: 2.8 nTPM (vital, limit 1); smooth muscle: 2.7 nTPM (vital, limit 1); duodenum: 2.7 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); skeletal muscle: 1.2 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRIM59,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000213213,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.288596,0.251111,0.180435,0,80,unavailable,1.6,1.1,1.4,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC183,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000213215,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR2F1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000213218,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.349687,0.3,0.249406,0,1,partial,14.6,5,8.4,"smooth muscle: 14.6 nTPM (vital, limit 3); lung: 3.4 nTPM (vital, limit 3); pituitary gland: 1.9 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review;thymic_function_review,salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CSH2,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased",False,False,False,False,False,unchanged,
ENSG00000213231,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 69.4444% (minimum 75%, Missing); lymph node: 54.3478% (minimum 70%, Missing)",0.13125,-0.156522,-0.0555556,0,80,unavailable,1.1,2.1,0.7,"bone marrow: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TCL1B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000213265,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TSGA13,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding,True,True,True,True,True,unchanged,
ENSG00000213401,True,compatible,,True,True,True,,0.35,0.3,0.09375,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEA12,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000213471,True,compatible,,True,True,True,,0.35,0.3,0.2375,0,4,partial,0.1,0.1,0,,,49,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TTLL13,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000213588,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.4545% (minimum 75%, Missing); cerebellum: 72.7273% (minimum 75%, Missing); cerebral cortex: 72.7273% (minimum 75%, Missing); choroid plexus: 73.4694% (minimum 75%, Missing); esophagus: 66.0550% (minimum 70%, Missing); heart muscle: 71.2871% (minimum 75%, Missing); hypothalamus: 73.4694% (minimum 75%, Missing); kidney: 62.6087% (minimum 75%, Missing); liver: 69.9029% (minimum 75%, Missing); pancreas: 71.2871% (minimum 75%, Missing); pituitary gland: 42.6036% (minimum 75%, Missing); small intestine: 72.7273% (minimum 75%, Missing)",0.0105505,-0.0394495,-0.323964,0,80,unavailable,9.7,3.7,3.7,"pituitary gland: 9.7 nTPM (vital, limit 1); kidney: 4.3 nTPM (vital, limit 1); adrenal gland: 3.8 nTPM (vital, limit 1); esophagus: 3.7 nTPM (protected, limit 3); liver: 3.1 nTPM (vital, limit 1); pancreas: 2.9 nTPM (vital, limit 1); heart muscle: 2.9 nTPM (vital, limit 1); small intestine: 2.7 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); cerebral cortex: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); duodenum: 2.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); hippocampal formation: 2 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZBTB9,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000213714,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344633,0.297309,0.241971,0,3,partial,11.6,1.3,2.5,"bone marrow: 11.6 nTPM (vital, limit 6)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM209B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000213782,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 55.9937% (minimum 60%, Approved); adrenal gland: 60.2716% (minimum 75%, Missing); amygdala: 65.7407% (minimum 75%, Missing); basal ganglia: 65.0183% (minimum 75%, Missing); bone marrow: 46.6491% (minimum 75%, Missing); cerebellum: 62.6102% (minimum 75%, Missing); cerebral cortex: 64.6630% (minimum 75%, Missing); choroid plexus: 50.2833% (minimum 75%, Missing); colon: 55.5556% (minimum 70%, Missing); duodenum: 66.7293% (minimum 75%, Missing); esophagus: 55.6426% (minimum 70%, Missing); heart muscle: 61.4187% (minimum 75%, Missing); hippocampal formation: 65.4982% (minimum 75%, Missing); hypothalamus: 65.7407% (minimum 75%, Missing); kidney: 53.4639% (minimum 75%, Missing); liver: 49.1690% (minimum 75%, Missing); lung: 59.5638% (minimum 75%, Missing); lymph node: 52.6706% (minimum 70%, Missing); midbrain: 64.6630% (minimum 75%, Missing); pancreas: 54.2813% (minimum 75%, Missing); parathyroid gland: 50.1412% (minimum 70%, Missing); pituitary gland: 67.4905% (minimum 75%, Missing); rectum: 58.1967% (minimum 70%, Missing); retina: 68.4008% (minimum 75%, Missing); salivary gland: 59.9662% (minimum 70%, Missing); skeletal muscle: 45.2229% (minimum 75%, Missing); skin: 54.5315% (minimum 65%, Missing); small intestine: 62.7208% (minimum 75%, Missing); smooth muscle: 52.4372% (minimum 75%, Missing); spinal cord: 63.8489% (minimum 75%, Missing); stomach: 55.4688% (minimum 70%, Missing); thymus: 50.6419% (minimum 65%, Missing); thyroid gland: 52.3599% (minimum 65%, Missing); tongue: 47.0199% (minimum 70%, Missing); urinary bladder: 43.6118% (minimum 70%, Missing)",-0.143581,-0.263882,-0.297771,0,1,partial,43,45.9,34.6,"urinary bladder: 45.9 nTPM (protected, limit 3); skeletal muscle: 43 nTPM (vital, limit 1); bone marrow: 40.6 nTPM (vital, limit 1); tongue: 40 nTPM (protected, limit 3); liver: 36.7 nTPM (vital, limit 1); parathyroid gland: 35.3 nTPM (protected, limit 3); choroid plexus: 35.1 nTPM (vital, limit 1); thymus: 34.6 nTPM (manageable, limit 5); thyroid gland: 32.3 nTPM (manageable, limit 5); smooth muscle: 32.2 nTPM (vital, limit 1); lymph node: 31.9 nTPM (protected, limit 3); kidney: 30.9 nTPM (vital, limit 1); pancreas: 29.9 nTPM (vital, limit 1); skin: 29.6 nTPM (manageable, limit 5); stomach: 28.5 nTPM (protected, limit 3); colon: 28.4 nTPM (protected, limit 3); esophagus: 28.3 nTPM (protected, limit 3); adipose tissue: 27.9 nTPM (manageable, limit 10); rectum: 25.5 nTPM (protected, limit 3); lung: 24.1 nTPM (vital, limit 1); salivary gland: 23.7 nTPM (protected, limit 3); adrenal gland: 23.4 nTPM (vital, limit 1); spleen: 22.8 nTPM (manageable, limit 10); heart muscle: 22.3 nTPM (vital, limit 1); cerebellum: 21.2 nTPM (vital, limit 1); small intestine: 21.1 nTPM (vital, limit 1); spinal cord: 20.1 nTPM (vital, limit 1); cerebral cortex: 19.4 nTPM (vital, limit 1); midbrain: 19.4 nTPM (vital, limit 1); basal ganglia: 19.1 nTPM (vital, limit 1); hippocampal formation: 18.7 nTPM (vital, limit 1); hypothalamus: 18.5 nTPM (vital, limit 1); amygdala: 18.5 nTPM (vital, limit 1); duodenum: 17.7 nTPM (vital, limit 1); pituitary gland: 17.1 nTPM (vital, limit 1); retina: 16.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: High (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: High (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / chondrocytes: Medium (Approved); soft tissue 1 / fibroblasts: Medium (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DDX47,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000213799,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.9375% (minimum 65%, Missing); adrenal gland: 69.6429% (minimum 75%, Missing); bone marrow: 44.3182% (minimum 75%, Missing); cerebellum: 70.9091% (minimum 75%, Missing); colon: 58.2090% (minimum 70%, Missing); duodenum: 61.9048% (minimum 75%, Missing); esophagus: 61.9048% (minimum 70%, Missing); heart muscle: 66.1017% (minimum 75%, Missing); kidney: 61.9048% (minimum 75%, Missing); liver: 72.2222% (minimum 75%, Missing); lung: 58.2090% (minimum 75%, Missing); lymph node: 48.1481% (minimum 70%, Missing); pancreas: 66.1017% (minimum 75%, Missing); parathyroid gland: 52.7027% (minimum 70%, Missing); rectum: 56.5217% (minimum 70%, Missing); salivary gland: 66.1017% (minimum 70%, Missing); skin: 56.5217% (minimum 65%, Missing); small intestine: 60.9375% (minimum 75%, Missing); smooth muscle: 67.2414% (minimum 75%, Missing); spleen: 52.7027% (minimum 65%, Missing); stomach: 52.7027% (minimum 70%, Missing); thymus: 48.7500% (minimum 65%, Missing); thyroid gland: 52.0000% (minimum 65%, Missing); tongue: 67.2414% (minimum 70%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.1625,-0.218519,-0.306818,0,80,unavailable,4.9,4.2,4.1,"bone marrow: 4.9 nTPM (vital, limit 1); lymph node: 4.2 nTPM (protected, limit 3); stomach: 3.5 nTPM (protected, limit 3); parathyroid gland: 3.5 nTPM (protected, limit 3); lung: 2.8 nTPM (vital, limit 1); small intestine: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); smooth muscle: 1.9 nTPM (vital, limit 1); adrenal gland: 1.7 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); liver: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF845,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000213927,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"skin: 5.3510% (minimum 65%, Missing)",-0.59649,0.288848,0.193262,0,6,partial,1.6,0.7,470.5,"skin: 470.5 nTPM (manageable, limit 5); bone marrow: 1.6 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / fibrohistiocytic cells: High (Enhanced); spleen / cells in red pulp: Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 1 / cells in spinous layer; skin 2 / cells in spinous layer; skin 2 / fibrohistiocytic cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCL27,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000214107,True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEB1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000214216,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 61.5385% (minimum 75%, Missing)",0.35,0.3,-0.134615,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IQCJ,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000214226,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 59.3750% (minimum 60%, Approved); amygdala: 65.5172% (minimum 75%, Missing); basal ganglia: 70.3704% (minimum 75%, Missing); cerebellum: 67.8571% (minimum 70%, Approved); cerebral cortex: 67.8571% (minimum 75%, Missing); choroid plexus: 73.0769% (minimum 75%, Missing); colon: 59.3750% (minimum 70%, Missing); duodenum: 73.0769% (minimum 75%, Missing); heart muscle: 67.8571% (minimum 70%, Approved); hippocampal formation: 63.3333% (minimum 75%, Missing); hypothalamus: 57.5758% (minimum 75%, Missing); liver: 46.3415% (minimum 70%, Approved); lung: 55.8824% (minimum 70%, Approved); lymph node: 55.8824% (minimum 65%, Approved); midbrain: 65.5172% (minimum 75%, Missing); pancreas: 54.2857% (minimum 70%, Approved); pituitary gland: 59.3750% (minimum 75%, Missing); retina: 70.3704% (minimum 75%, Missing); small intestine: 54.2857% (minimum 75%, Missing); smooth muscle: 63.3333% (minimum 70%, Approved); spinal cord: 57.5758% (minimum 75%, Missing); spleen: 42.2222% (minimum 60%, Approved); stomach: 67.8571% (minimum 70%, Missing); thymus: 26.3889% (minimum 65%, Missing); thyroid gland: 59.3750% (minimum 60%, Approved); urinary bladder: 57.5758% (minimum 65%, Approved)",-0.386111,-0.10625,-0.236585,0,1,partial,2.2,1.5,5.3,"thymus: 5.3 nTPM (manageable, limit 5); liver: 2.2 nTPM (vital, limit 2); small intestine: 1.6 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",caudate / glial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: High (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); hippocampus / glial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Low (Approved); rectum / glandular cells: High (Approved); small intestine / glandular cells: High (Approved); stomach 2 / glandular cells: Medium (Approved),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C17orf67,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000214274,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 60.6911% (minimum 65%, Missing); choroid plexus: 70.6918% (minimum 75%, Missing); colon: 64.0821% (minimum 70%, Missing); duodenum: 71.4104% (minimum 75%, Missing); liver: 1.8881% (minimum 75%, Missing); pancreas: 65.2729% (minimum 75%, Missing); rectum: 55.9761% (minimum 70%, Missing); salivary gland: 52.4254% (minimum 70%, Missing); small intestine: 68.1212% (minimum 75%, Missing); stomach: 49.8227% (minimum 70%, Missing)",-0.0430886,-0.201773,-0.731119,0,80,unavailable,2920.4,56.6,36.4,"liver: 2920.4 nTPM (vital, limit 1); stomach: 56.6 nTPM (protected, limit 3); salivary gland: 51 nTPM (protected, limit 3); rectum: 44.2 nTPM (protected, limit 3); adipose tissue: 36.4 nTPM (manageable, limit 5); colon: 31.5 nTPM (protected, limit 3); pancreas: 29.9 nTPM (vital, limit 1); skin: 26.5 nTPM (manageable, limit 5); small intestine: 26.3 nTPM (vital, limit 1); urinary bladder: 24 nTPM (protected, limit 3); choroid plexus: 23.3 nTPM (vital, limit 1); duodenum: 22.5 nTPM (vital, limit 1); lung: 18 nTPM (vital, limit 1); kidney: 17.7 nTPM (vital, limit 1); heart muscle: 16.3 nTPM (vital, limit 1); smooth muscle: 10.1 nTPM (vital, limit 1); tongue: 10.1 nTPM (protected, limit 3); esophagus: 9.5 nTPM (protected, limit 3); thyroid gland: 8.5 nTPM (manageable, limit 5); spleen: 7.2 nTPM (manageable, limit 5); skeletal muscle: 6 nTPM (vital, limit 1); parathyroid gland: 5.1 nTPM (protected, limit 3); pituitary gland: 4.8 nTPM (vital, limit 1); spinal cord: 3.9 nTPM (vital, limit 1); lymph node: 3.4 nTPM (protected, limit 3); hippocampal formation: 3 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); adrenal gland: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); amygdala: 2.5 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); cerebellum: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ANG,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000214300,True,compatible,,True,True,True,,0.35,0.3,0.21,0,3,partial,0.1,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPDYE3,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,True,True,True,True,gained,selectivity_revised
ENSG00000214324,False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,PRR23E,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive noncoding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000214338,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 42.3077% (minimum 75%, Missing); amygdala: 64.7059% (minimum 75%, Missing); cerebellum: 73.3333% (minimum 75%, Missing); cerebral cortex: 12.0879% (minimum 75%, Missing); choroid plexus: 73.3333% (minimum 75%, Missing); colon: 64.7059% (minimum 70%, Missing); duodenum: 64.7059% (minimum 75%, Missing); esophagus: 47.8261% (minimum 70%, Missing); hippocampal formation: 61.1111% (minimum 75%, Missing); hypothalamus: 61.1111% (minimum 75%, Missing); lung: 32.3529% (minimum 75%, Missing); lymph node: 68.7500% (minimum 70%, Missing); midbrain: 37.9310% (minimum 75%, Missing); pancreas: 55.0000% (minimum 75%, Missing); pituitary gland: 36.6667% (minimum 75%, Missing); rectum: 64.7059% (minimum 70%, Missing); retina: 25.0000% (minimum 75%, Missing); salivary gland: 68.7500% (minimum 70%, Missing); skin: 64.7059% (minimum 65%, Missing); small intestine: 47.8261% (minimum 75%, Missing); spinal cord: 23.4043% (minimum 75%, Missing); spleen: 52.3810% (minimum 65%, Missing); stomach: 33.3333% (minimum 70%, Missing); thyroid gland: 55.0000% (minimum 65%, Missing); urinary bladder: 64.7059% (minimum 70%, Missing)",-0.12619,-0.366667,-0.629121,0,80,unavailable,8,2.2,1,"cerebral cortex: 8 nTPM (vital, limit 1); spinal cord: 3.6 nTPM (vital, limit 1); retina: 3.3 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MTCL3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000214360,True,compatible,,True,True,True,,0.35,0.3,0.229798,0,80,unavailable,0.2,0,0,,,0,not_established,required,in_situ_inflammation_review,gallbladder,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EFCAB9,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000214415,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 15.0000% (minimum 75%, Missing); small intestine: 20.0000% (minimum 75%, Missing)",0.1,0.3,-0.6,0,10,partial,1.7,0,0.2,"duodenum: 1.7 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1)",duodenum / endocrine cells: High (Enhanced); small intestine / endocrine cells: High (Enhanced),70,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GNAT3,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000214511,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"adipose tissue: 50.0000% (minimum 65%, Missing); bone marrow: 75.0000% (minimum 75%, Missing); cerebral cortex: 75.0000% (minimum 75%, Missing); liver: 33.3333% (minimum 75%, Missing); lung: 60.0000% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); pancreas: 27.2727% (minimum 75%, Missing); parathyroid gland: 50.0000% (minimum 70%, Missing); pituitary gland: 75.0000% (minimum 75%, Missing); retina: 60.0000% (minimum 75%, Missing); salivary gland: 60.0000% (minimum 70%, Missing); skeletal muscle: 42.8571% (minimum 75%, Missing); skin: 42.8571% (minimum 65%, Missing); small intestine: 75.0000% (minimum 75%, Missing); smooth muscle: 60.0000% (minimum 75%, Missing); spleen: 60.0000% (minimum 65%, Missing); stomach: 42.8571% (minimum 70%, Missing); thyroid gland: 42.8571% (minimum 65%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.221429,-0.271429,-0.477273,0,80,unavailable,0.8,0.4,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,HIGD1C,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000214681,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IQCF5,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000214686,True,compatible,,True,True,True,,0.35,0.295238,0.235849,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IQCF6,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000214782,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"duodenum: 24.2678% (minimum 75%, Missing); small intestine: 65.9091% (minimum 75%, Missing)",0.35,0.3,-0.507322,0,3,partial,18.1,0.2,0,"duodenum: 18.1 nTPM (vital, limit 1); small intestine: 3 nTPM (vital, limit 1)",colon / glandular cells: Low (Approved); duodenum / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); small intestine / glandular cells: Medium (Approved),53,not_established,required,lymphatic_and_immune_function_review,lymph node,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,MS4A18,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000214814,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 32.8767% (minimum 70%, Missing); duodenum: 46.1538% (minimum 75%, Missing); kidney: 43.6364% (minimum 60%, Enhanced); rectum: 18.7500% (minimum 70%, Missing); small intestine: 35.2941% (minimum 75%, Missing); stomach: 5.4054% (minimum 70%, Missing); thyroid gland: 52.1739% (minimum 65%, Missing)",-0.128261,-0.645946,-0.397059,0,9,partial,4.4,42,2.2,"stomach: 42 nTPM (protected, limit 3); rectum: 10.4 nTPM (protected, limit 3); colon: 4.9 nTPM (protected, limit 3); small intestine: 4.4 nTPM (vital, limit 1); duodenum: 2.8 nTPM (vital, limit 1)",adrenal gland / glandular cells: Low (Enhanced); bronchus / respiratory epithelial cells: Low (Enhanced); colon / goblet cells: Low (Enhanced); duodenum / goblet cells: Medium (Enhanced); rectum / goblet cells: Medium (Enhanced); skeletal muscle / myocytes: Low (Enhanced); small intestine / goblet cells: High (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: Low (Enhanced),70,not_established,required,in_situ_inflammation_review,appendix; appendix / goblet cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FER1L6,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000214819,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293421,0.122832,0,80,unavailable,2.2,0.1,0,"hippocampal formation: 2.2 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,lymph node; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CDRT15L2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000214842,True,compatible,,True,True,True,,0.33913,0.278495,0.218085,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RAD51AP2,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000214866,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.302381,0.27561,0.0192308,0,80,unavailable,1.2,0.1,0.2,"choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DCDC2C,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000214897,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.341453,0.3,0.22479,0,80,unavailable,0.3,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,PNMA6E,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000214929,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA31D1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000214946,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.343548,0.293548,0.0357143,0,80,unavailable,4.2,0.1,0.1,"basal ganglia: 4.2 nTPM (vital, limit 1); hippocampal formation: 3 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebral cortex: 1.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TBC1D26,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000215009,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"retina: 66.6667% (minimum 75%, Missing); small intestine: 72.7273% (minimum 75%, Missing); spleen: 61.5385% (minimum 65%, Missing)",-0.0346154,0.188889,-0.0833333,0,80,unavailable,0.4,0.1,0.5,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; gallbladder; lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ACSM4,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000215113,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CXorf49B,current_adaptive,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000215115,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CXorf49,current_adaptive,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000215126,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.8140% (minimum 60%, Approved); adrenal gland: 32.0000% (minimum 75%, Missing); amygdala: 53.3333% (minimum 75%, Missing); basal ganglia: 61.5385% (minimum 75%, Missing); bone marrow: 52.1739% (minimum 70%, Approved); cerebellum: 68.5714% (minimum 75%, Missing); cerebral cortex: 58.5366% (minimum 75%, Missing); colon: 57.1429% (minimum 70%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 46.1538% (minimum 70%, Missing); heart muscle: 42.8571% (minimum 75%, Missing); hippocampal formation: 66.6667% (minimum 75%, Missing); hypothalamus: 55.8140% (minimum 75%, Missing); kidney: 42.1053% (minimum 75%, Missing); liver: 25.2632% (minimum 75%, Missing); lung: 55.8140% (minimum 75%, Missing); midbrain: 54.5455% (minimum 75%, Missing); pancreas: 42.1053% (minimum 75%, Missing); pituitary gland: 48.0000% (minimum 75%, Missing); retina: 58.5366% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing); skeletal muscle: 40.6780% (minimum 70%, Approved); skin: 63.1579% (minimum 65%, Missing); small intestine: 57.1429% (minimum 75%, Missing); spinal cord: 53.3333% (minimum 75%, Missing); spleen: 54.5455% (minimum 65%, Missing); stomach: 52.1739% (minimum 70%, Missing); thyroid gland: 53.3333% (minimum 65%, Missing); urinary bladder: 68.5714% (minimum 70%, Missing)",-0.116667,-0.238462,-0.497368,0,7,partial,7.1,2.8,2.1,"liver: 7.1 nTPM (vital, limit 1); adrenal gland: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.5 nTPM (vital, limit 2); pancreas: 3.3 nTPM (vital, limit 1); kidney: 3.3 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); pituitary gland: 2.6 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 2); amygdala: 2.1 nTPM (vital, limit 1); spinal cord: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.7 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); duodenum: 1.2 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Medium (Approved); caudate / neuronal cells: High (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / glial cells: Medium (Approved); cerebral cortex / neuronal cells: High (Approved); cerebral cortex / neuropil: Medium (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: High (Approved); lung / macrophages: Medium (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Low (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Low (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); spleen / cells in red pulp: Medium (Approved); spleen / cells in white pulp: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNG1F,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000215131,True,compatible,,True,True,True,,0.35,0.3,0.247877,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C16orf90,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000215148,True,compatible,,True,True,True,,0.35,0.05,0.173077,0,80,unavailable,0.1,0.4,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRSS41,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000215186,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"liver: 62.5000% (minimum 65%, Supported)",0.35,0.3,-0.025,0,1,partial,4.2,0,0.2,"liver: 4.2 nTPM (vital, limit 3)",,54,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GOLGA6B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000215203,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.238889,0.3,0.25,0,80,unavailable,0,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,GRXCR1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000215262,True,compatible,,True,True,True,,0.35,0.3,0.235507,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KCNU1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000215269,True,compatible,,True,True,True,,0.35,0.3,0.233633,0,4,partial,1,5.9,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GAGE12G,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,True,True,True,False,gained,selectivity_revised
ENSG00000215274,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"pituitary gland: 66.6667% (minimum 75%, Missing)",0.338889,0.241176,-0.0833333,0,4,partial,0.8,0.1,0.2,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GAGE10,current_adaptive,True,False,False,False,10.1186/s12967-024-04918-0,Seager 2024 · panel,False,False,False,False,False,unchanged,
ENSG00000215277,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"kidney: 17.2185% (minimum 75%, Missing)",0.278571,0.262963,-0.577815,0,80,unavailable,25,0.2,0.4,"kidney: 25 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RNF212B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.18632/oncotarget.21715,Chang 2019 · TGCT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000215343,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF705D,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000215356,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ZNF705B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000215372,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.107143,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ZNF705G,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000215421,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 64.4068% (minimum 65%, Uncertain); adrenal gland: 67.8571% (minimum 75%, Missing); basal ganglia: 74.5098% (minimum 75%, Missing); bone marrow: 42.6966% (minimum 75%, Missing); cerebellum: 64.4068% (minimum 75%, Missing); cerebral cortex: 63.3333% (minimum 75%, Missing); colon: 58.4615% (minimum 70%, Missing); duodenum: 65.5172% (minimum 75%, Missing); esophagus: 62.2951% (minimum 70%, Missing); heart muscle: 55.8824% (minimum 75%, Missing); kidney: 63.3333% (minimum 75%, Missing); liver: 64.4068% (minimum 75%, Missing); lung: 63.3333% (minimum 75%, Missing); lymph node: 55.0725% (minimum 70%, Missing); pancreas: 65.5172% (minimum 75%, Missing); parathyroid gland: 51.3514% (minimum 70%, Missing); pituitary gland: 71.6981% (minimum 75%, Missing); rectum: 64.4068% (minimum 70%, Missing); retina: 58.4615% (minimum 75%, Missing); salivary gland: 63.3333% (minimum 70%, Missing); skeletal muscle: 50.0000% (minimum 75%, Missing); skin: 63.3333% (minimum 65%, Missing); small intestine: 63.3333% (minimum 75%, Missing); smooth muscle: 56.7164% (minimum 75%, Missing); spinal cord: 74.5098% (minimum 75%, Missing); spleen: 54.2857% (minimum 65%, Missing); stomach: 64.4068% (minimum 70%, Missing); thymus: 43.1818% (minimum 65%, Missing); thyroid gland: 52.7778% (minimum 65%, Missing); tongue: 54.2857% (minimum 70%, Missing); urinary bladder: 62.2951% (minimum 70%, Missing)",-0.218182,-0.186486,-0.323034,0,5,partial,5.1,3.6,5,"bone marrow: 5.1 nTPM (vital, limit 1); skeletal muscle: 3.8 nTPM (vital, limit 1); parathyroid gland: 3.6 nTPM (protected, limit 3); tongue: 3.2 nTPM (protected, limit 3); lymph node: 3.1 nTPM (protected, limit 3); heart muscle: 3 nTPM (vital, limit 1); smooth muscle: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); liver: 2.1 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Uncertain); bone marrow / hematopoietic cells: High (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / glial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Low (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / cholangiocytes: Low (Uncertain); liver / hepatocytes: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF407,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000215455,False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,10.1,"skin: 10.1 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,KRTAP10-1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000215474,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"cerebellum: 70.0000% (minimum 75%, Missing)",0.35,0.3,-0.05,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,SKOR2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000215529,True,compatible,,True,True,True,,0.266667,0.270588,0.166667,0,80,unavailable,0.3,0.1,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EFCAB8,current_adaptive,True,False,True,False,10.1371/journal.pgen.1011734,Loriot 2025 · preferential,False,True,True,True,True,gained,selectivity_revised
ENSG00000215568,True,compatible,,True,True,True,,0.35,0.3,0.202381,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GAB4,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000215817,True,compatible,,True,True,True,,0.31,0.26,0.191176,0,80,unavailable,0.3,0.2,0.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZC3H11B,current_adaptive,True,False,True,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict,False,True,True,True,True,gained,selectivity_revised
ENSG00000215883,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 41.0959% (minimum 75%, Missing); amygdala: 61.2245% (minimum 75%, Missing); basal ganglia: 62.5000% (minimum 75%, Missing); bone marrow: 58.8235% (minimum 75%, Missing); cerebellum: 61.2245% (minimum 75%, Missing); cerebral cortex: 58.8235% (minimum 75%, Missing); choroid plexus: 58.8235% (minimum 75%, Missing); colon: 57.6923% (minimum 70%, Missing); duodenum: 55.5556% (minimum 75%, Missing); esophagus: 61.2245% (minimum 70%, Missing); heart muscle: 52.6316% (minimum 75%, Missing); hippocampal formation: 58.8235% (minimum 75%, Missing); hypothalamus: 65.2174% (minimum 75%, Missing); kidney: 55.5556% (minimum 75%, Missing); liver: 50.8475% (minimum 75%, Missing); lung: 63.8298% (minimum 75%, Missing); lymph node: 56.6038% (minimum 70%, Missing); midbrain: 60.0000% (minimum 75%, Missing); pancreas: 42.2535% (minimum 75%, Missing); parathyroid gland: 49.1803% (minimum 70%, Missing); pituitary gland: 45.4545% (minimum 75%, Missing); rectum: 56.6038% (minimum 70%, Missing); retina: 54.5455% (minimum 75%, Missing); salivary gland: 53.5714% (minimum 70%, Missing); skeletal muscle: 43.4783% (minimum 75%, Missing); skin: 48.3871% (minimum 65%, Missing); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 60.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 60%, Approved); stomach: 50.0000% (minimum 70%, Missing); thyroid gland: 55.5556% (minimum 65%, Missing); tongue: 52.6316% (minimum 70%, Missing); urinary bladder: 61.2245% (minimum 70%, Missing)",-0.166129,-0.208197,-0.339041,0,7,partial,4.3,3.1,3.2,"adrenal gland: 4.3 nTPM (vital, limit 1); pancreas: 4.1 nTPM (vital, limit 1); skeletal muscle: 3.9 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); parathyroid gland: 3.1 nTPM (protected, limit 3); liver: 2.9 nTPM (vital, limit 1); heart muscle: 2.7 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); cerebral cortex: 2.1 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); small intestine: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); lung: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells type I: Medium (Approved); lung / alveolar cells type II: Medium (Approved); lung / macrophages: Medium (Approved); nasopharynx / respiratory epithelial cells: High (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 2 / fibroblasts: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CYB5RL,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000215906,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"retina: 5.0000% (minimum 75%, Missing)",0.35,0.3,-0.7,0,80,unavailable,3.8,0,0,"retina: 3.8 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,LACTBL1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000215910,True,compatible,,True,True,True,,0.346364,0.296364,0.246364,0,6,partial,0.5,0.1,0.3,,,69,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; skin 1 / hair follicles; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C1orf167,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000216649,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GAGE12E,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000216937,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.329618,0.280867,0.217296,0,80,unavailable,2.6,1.5,1.6,"retina: 2.6 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); pancreas: 1.4 nTPM (vital, limit 1); pituitary gland: 1.1 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC7,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT,False,False,False,False,False,unchanged,
ENSG00000217442,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.33784,0.295674,0.230824,0,80,unavailable,2.7,0.6,1.7,"kidney: 2.7 nTPM (vital, limit 1); midbrain: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); amygdala: 2.2 nTPM (vital, limit 1); hypothalamus: 2 nTPM (vital, limit 1); cerebral cortex: 1.9 nTPM (vital, limit 1); liver: 1.7 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); retina: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SYCE3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000218819,True,compatible,,True,True,True,,0.35,0.3,0.104839,0,80,unavailable,0.9,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TDRD15,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000218823,True,compatible,,True,True,True,,0.35,0.3,0.243151,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PAPOLB,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000219073,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 53.2258% (minimum 55%, Supported); duodenum: 61.1111% (minimum 65%, Supported); heart muscle: 55.0000% (minimum 65%, Supported); pancreas: 0.0206% (minimum 75%, Missing); salivary gland: 51.0309% (minimum 60%, Supported); stomach: 37.2180% (minimum 60%, Supported)",-0.0177419,-0.22782,-0.749794,0,4,partial,48049.2,16.7,8.7,"pancreas: 48049.2 nTPM (vital, limit 1); stomach: 16.7 nTPM (protected, limit 6); salivary gland: 9.5 nTPM (protected, limit 6); heart muscle: 8.1 nTPM (vital, limit 3); duodenum: 6.3 nTPM (vital, limit 3); liver: 4.9 nTPM (vital, limit 3); pituitary gland: 2.2 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CELA3B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000219435,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347899,0.299124,0.244244,0,80,unavailable,3.3,0.5,1.2,"hippocampal formation: 3.3 nTPM (vital, limit 1); amygdala: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.9 nTPM (vital, limit 1); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CATSPERZ,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000220205,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 57.4254% (minimum 75%, Missing); amygdala: 33.6656% (minimum 75%, Missing); basal ganglia: 35.8303% (minimum 75%, Missing); bone marrow: 49.3147% (minimum 75%, Missing); cerebellum: 30.4676% (minimum 75%, Missing); cerebral cortex: 26.0097% (minimum 75%, Missing); choroid plexus: 68.8150% (minimum 75%, Missing); colon: 64.1971% (minimum 70%, Missing); heart muscle: 63.0957% (minimum 75%, Missing); hippocampal formation: 33.6861% (minimum 75%, Missing); hypothalamus: 36.6556% (minimum 75%, Missing); kidney: 56.5812% (minimum 75%, Missing); liver: 73.9500% (minimum 75%, Missing); lung: 66.6801% (minimum 75%, Missing); midbrain: 39.2087% (minimum 75%, Missing); pancreas: 67.9114% (minimum 75%, Missing); parathyroid gland: 48.5765% (minimum 70%, Missing); pituitary gland: 42.7759% (minimum 75%, Missing); retina: 27.4598% (minimum 75%, Missing); skeletal muscle: 63.4829% (minimum 75%, Missing); skin: 58.9808% (minimum 65%, Missing); small intestine: 65.0295% (minimum 75%, Missing); smooth muscle: 71.7693% (minimum 75%, Missing); spinal cord: 49.2413% (minimum 75%, Missing); spleen: 59.4896% (minimum 65%, Missing); stomach: 65.9100% (minimum 70%, Missing); thyroid gland: 62.5709% (minimum 65%, Missing); urinary bladder: 68.4167% (minimum 70%, Missing)",-0.0601924,-0.214235,-0.489903,0,80,unavailable,470.8,175.2,115.1,"cerebral cortex: 470.8 nTPM (vital, limit 1); retina: 437.2 nTPM (vital, limit 1); cerebellum: 377.7 nTPM (vital, limit 1); amygdala: 326.1 nTPM (vital, limit 1); hippocampal formation: 325.8 nTPM (vital, limit 1); basal ganglia: 296.4 nTPM (vital, limit 1); hypothalamus: 286 nTPM (vital, limit 1); midbrain: 256.6 nTPM (vital, limit 1); pituitary gland: 221.4 nTPM (vital, limit 1); parathyroid gland: 175.2 nTPM (protected, limit 3); spinal cord: 170.6 nTPM (vital, limit 1); bone marrow: 170.1 nTPM (vital, limit 1); kidney: 127 nTPM (vital, limit 1); adrenal gland: 122.7 nTPM (vital, limit 1); skin: 115.1 nTPM (manageable, limit 5); spleen: 112.7 nTPM (manageable, limit 5); thyroid gland: 99 nTPM (manageable, limit 5); heart muscle: 96.8 nTPM (vital, limit 1); skeletal muscle: 95.2 nTPM (vital, limit 1); colon: 92.3 nTPM (protected, limit 3); small intestine: 89 nTPM (vital, limit 1); adipose tissue: 85.7 nTPM (manageable, limit 5); stomach: 85.6 nTPM (protected, limit 3); lung: 82.7 nTPM (vital, limit 1); pancreas: 78.2 nTPM (vital, limit 1); urinary bladder: 76.4 nTPM (protected, limit 3); choroid plexus: 75 nTPM (vital, limit 1); salivary gland: 70 nTPM (protected, limit 3); thymus: 69.6 nTPM (manageable, limit 5); lymph node: 68.6 nTPM (protected, limit 3); smooth muscle: 65.1 nTPM (vital, limit 1); tongue: 61.1 nTPM (protected, limit 3); esophagus: 59.1 nTPM (protected, limit 3); liver: 58.3 nTPM (vital, limit 1); rectum: 49.7 nTPM (protected, limit 3); duodenum: 41.9 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,VAMP2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000221813,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing); pancreas: 28.5714% (minimum 75%, Missing)",0.35,0.3,-0.464286,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR6B1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000221826,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.6,0.1,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PSG3,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased",True,True,True,True,True,unchanged,
ENSG00000221843,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.314912,0.264912,0.0357143,0,80,unavailable,1.5,0.2,0.2,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA31H1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000221855,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TAS2R41,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000221867,True,compatible,,True,True,True,,0.325,0.3,0.25,0,80,unavailable,0,0,0.2,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEA3,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000221878,True,compatible,,True,True,True,,0.219231,0.3,0.238889,0,2,partial,0.5,0,1.2,,,53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PSG7,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,True,True,True,True,gained,selectivity_revised
ENSG00000221882,False,unresolved,incomplete_routine_rna,True,True,True,,0.253226,0.203226,0.00675676,9,80,unavailable,0.9,0.3,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; lymph node; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR3A2,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000221888,True,compatible,,True,True,True,,0.35,0.3,0.175926,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR1C1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000221900,True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,POM121L12,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000221910,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR2F2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000221926,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 68.3049% (minimum 75%, Uncertain); esophagus: 32.4440% (minimum 70%, Missing); salivary gland: 64.8571% (minimum 70%, Missing); skeletal muscle: 65.7336% (minimum 75%, Uncertain); skin: 61.0215% (minimum 65%, Missing); stomach: 68.0320% (minimum 70%, Missing); tongue: 69.3483% (minimum 70%, Missing); urinary bladder: 66.1808% (minimum 70%, Missing)",-0.0397849,-0.37556,-0.0926641,0,3,partial,35.5,141.8,43.5,"esophagus: 141.8 nTPM (protected, limit 3); skin: 43.5 nTPM (manageable, limit 5); salivary gland: 36.9 nTPM (protected, limit 3); skeletal muscle: 35.5 nTPM (vital, limit 1); urinary bladder: 34.8 nTPM (protected, limit 3); stomach: 32 nTPM (protected, limit 3); adrenal gland: 31.6 nTPM (vital, limit 1); tongue: 30.1 nTPM (protected, limit 3); duodenum: 22.5 nTPM (vital, limit 1); heart muscle: 22.3 nTPM (vital, limit 1); thyroid gland: 18.2 nTPM (manageable, limit 5); bone marrow: 17.8 nTPM (vital, limit 1); adipose tissue: 17.7 nTPM (manageable, limit 5); spinal cord: 14.8 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); colon: 13.6 nTPM (protected, limit 3); small intestine: 12.4 nTPM (vital, limit 1); midbrain: 12.2 nTPM (vital, limit 1); rectum: 11.5 nTPM (protected, limit 3); hypothalamus: 10.8 nTPM (vital, limit 1); thymus: 10.1 nTPM (manageable, limit 5); lymph node: 9.8 nTPM (protected, limit 3); smooth muscle: 9.6 nTPM (vital, limit 1); basal ganglia: 9.2 nTPM (vital, limit 1); kidney: 8.3 nTPM (vital, limit 1); cerebral cortex: 7.9 nTPM (vital, limit 1); amygdala: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.3 nTPM (vital, limit 1); choroid plexus: 7.1 nTPM (vital, limit 1); pancreas: 5.9 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); liver: 5.8 nTPM (vital, limit 1); cerebellum: 5.1 nTPM (vital, limit 1); retina: 4.5 nTPM (vital, limit 1); pituitary gland: 4.3 nTPM (vital, limit 1); parathyroid gland: 3.8 nTPM (protected, limit 3)",bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); kidney / cells in tubules: Medium (Uncertain); oral mucosa / squamous epithelial cells: Low (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain); thyroid gland / glandular cells: Low (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TRIM16,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000221947,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 73.1959% (minimum 75%, Missing); small intestine: 57.7236% (minimum 75%, Missing)",0.2375,0.116092,-0.172764,0,2,partial,5.2,1.6,0.9,"small intestine: 5.2 nTPM (vital, limit 1); duodenum: 2.6 nTPM (vital, limit 1); retina: 2 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / glandular cells: Low (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in tubules: Medium (Enhanced); lung / macrophages: Low (Enhanced); oral mucosa / squamous epithelial cells: Low (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); salivary gland / glandular cells: Low (Enhanced); skeletal muscle / myocytes: Low (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Low (Enhanced); urinary bladder / urothelial cells: Low (Enhanced),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,XKR9,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000221977,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR4E2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000222028,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"thymus: 0.9967% (minimum 65%, Missing)",-0.640033,0.3,0.25,0,4,partial,0,0,29.8,"thymus: 29.8 nTPM (manageable, limit 5)",thymus / cortical cells: Medium (Enhanced),52,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus; thymus / cortical cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PSMB11,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000222036,True,compatible,,True,True,True,,0.317914,0.283696,0.207672,0,80,unavailable,0.8,0.3,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,POTEM,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,True,True,True,True,gained,selectivity_revised
ENSG00000223510,True,compatible,,True,True,True,,0.21383,0.186463,0.212085,0,80,unavailable,0.8,2.6,3.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CDRT15,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,True,True,True,gained,grid_revised
ENSG00000223591,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 55.0000% (minimum 75%, Missing); basal ganglia: 22.0000% (minimum 75%, Missing); cerebral cortex: 64.7059% (minimum 75%, Missing); hippocampal formation: 68.7500% (minimum 75%, Missing); hypothalamus: 22.0000% (minimum 75%, Missing); midbrain: 64.7059% (minimum 75%, Missing)",0.35,0.3,-0.53,0,80,unavailable,3.9,0,0,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 3.9 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CENPVL1,current_adaptive,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict,False,False,False,False,False,unchanged,
ENSG00000223601,True,compatible,,True,True,True,,0.35,0.264286,0.214286,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EBLN1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000223614,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ZNF735,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000223802,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"amygdala: 17.4099% (minimum 75%, Missing); basal ganglia: 14.6079% (minimum 75%, Missing); cerebellum: 33.0243% (minimum 60%, Enhanced); cerebral cortex: 16.9240% (minimum 75%, Missing); choroid plexus: 66.4336% (minimum 75%, Missing); hippocampal formation: 16.7549% (minimum 75%, Missing); hypothalamus: 21.1581% (minimum 75%, Missing); midbrain: 15.2081% (minimum 75%, Missing); pituitary gland: 69.6822% (minimum 75%, Missing); spinal cord: 14.9764% (minimum 75%, Missing)",0.339583,0.0160804,-0.603921,0,10,partial,166.6,11.3,1,"basal ganglia: 166.6 nTPM (vital, limit 1); spinal cord: 161.8 nTPM (vital, limit 1); midbrain: 158.9 nTPM (vital, limit 1); hippocampal formation: 141.6 nTPM (vital, limit 1); cerebral cortex: 139.9 nTPM (vital, limit 1); amygdala: 135.2 nTPM (vital, limit 1); hypothalamus: 106.2 nTPM (vital, limit 1); cerebellum: 57.8 nTPM (vital, limit 6); skeletal muscle: 17.5 nTPM (vital, limit 6); choroid plexus: 14.4 nTPM (vital, limit 1); pituitary gland: 12.4 nTPM (vital, limit 1); tongue: 11.3 nTPM (protected, limit 3); retina: 4.6 nTPM (vital, limit 1); heart muscle: 4.2 nTPM (vital, limit 1); colon: 3.4 nTPM (protected, limit 3)",caudate / glial cells: Low (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); colon / endocrine cells: Medium (Enhanced); colon / enterocytes: Low (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); lymph node / germinal center cells: Low (Enhanced); rectum / endocrine cells: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Low (Enhanced),71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node / germinal center cells; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CERS1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000224089,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT47A10,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000224107,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.223913,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ETDB,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000224440,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,CXorf51A,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000224586,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GPX5,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000224659,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.160931,0,4,partial,2.2,0.2,0,"retina: 2.2 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GAGE12J,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000224902,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GAGE12H,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000224960,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PPP4R3C,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Gong 2021 · reproductive coding;Loriot 2025 · strict,True,True,True,True,True,unchanged,
ENSG00000225614,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 62.8571% (minimum 75%, Missing); basal ganglia: 66.6667% (minimum 75%, Missing); cerebral cortex: 62.8571% (minimum 75%, Missing); hippocampal formation: 61.1111% (minimum 75%, Missing); hypothalamus: 70.9677% (minimum 75%, Missing); midbrain: 70.9677% (minimum 75%, Missing); smooth muscle: 73.3333% (minimum 75%, Missing); spinal cord: 70.9677% (minimum 75%, Missing)",0.0596774,0.00967742,-0.138889,0,80,unavailable,1.4,0.9,0.9,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF469,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000225781,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR6V1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000225828,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.281946,0.262779,0.173077,0,80,unavailable,9.7,4.5,8.5,"liver: 9.7 nTPM (vital, limit 1); spleen: 8.5 nTPM (manageable, limit 5); kidney: 8.5 nTPM (vital, limit 1); cerebellum: 8 nTPM (vital, limit 1); amygdala: 7.4 nTPM (vital, limit 1); adrenal gland: 6.5 nTPM (vital, limit 1); thyroid gland: 6.3 nTPM (manageable, limit 5); basal ganglia: 6.2 nTPM (vital, limit 1); midbrain: 6.1 nTPM (vital, limit 1); hippocampal formation: 5.7 nTPM (vital, limit 1); cerebral cortex: 5.6 nTPM (vital, limit 1); hypothalamus: 5.5 nTPM (vital, limit 1); small intestine: 5.4 nTPM (vital, limit 1); skin: 5.3 nTPM (manageable, limit 5); spinal cord: 4.9 nTPM (vital, limit 1); urinary bladder: 4.5 nTPM (protected, limit 3); lung: 4.2 nTPM (vital, limit 1); stomach: 4 nTPM (protected, limit 3); salivary gland: 3.9 nTPM (protected, limit 3); pituitary gland: 3.9 nTPM (vital, limit 1); colon: 3.7 nTPM (protected, limit 3); pancreas: 3.4 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); bone marrow: 2.1 nTPM (vital, limit 1); skeletal muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM229A,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,False,False,False,False,unchanged,
ENSG00000226023,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT47A6,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000226372,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,bronchus / respiratory epithelial cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Low (Enhanced),52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DCAF8L1,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000226600,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT47A9,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000226650,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KIF4B,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000226685,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT47A12,current_adaptive,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000226929,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT47A11,current_adaptive,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000226941,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RBMY1J,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000227059,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ANHX,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000227124,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 72.8155% (minimum 75%, Missing); basal ganglia: 74.6269% (minimum 75%, Missing); duodenum: 73.1707% (minimum 75%, Missing); heart muscle: 72.4638% (minimum 75%, Missing); hypothalamus: 74.2574% (minimum 75%, Missing); kidney: 60.9756% (minimum 75%, Missing); liver: 66.0793% (minimum 75%, Missing); midbrain: 73.8916% (minimum 75%, Missing); pancreas: 63.2911% (minimum 75%, Missing); parathyroid gland: 64.9351% (minimum 70%, Missing); pituitary gland: 62.5000% (minimum 75%, Missing); rectum: 69.7674% (minimum 70%, Missing); retina: 66.6667% (minimum 75%, Missing); salivary gland: 68.1818% (minimum 70%, Missing); skin: 60.7287% (minimum 65%, Missing); spinal cord: 70.7547% (minimum 75%, Missing); stomach: 67.5676% (minimum 70%, Missing); thyroid gland: 61.9835% (minimum 65%, Missing)",-0.0427126,-0.0506494,-0.140244,0,80,unavailable,9.6,8.1,9.7,"skin: 9.7 nTPM (manageable, limit 5); kidney: 9.6 nTPM (vital, limit 1); thyroid gland: 9.2 nTPM (manageable, limit 5); pituitary gland: 9 nTPM (vital, limit 1); pancreas: 8.7 nTPM (vital, limit 1); parathyroid gland: 8.1 nTPM (protected, limit 3); liver: 7.7 nTPM (vital, limit 1); retina: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 3); salivary gland: 7 nTPM (protected, limit 3); spleen: 6.9 nTPM (manageable, limit 5); rectum: 6.5 nTPM (protected, limit 3); spinal cord: 6.2 nTPM (vital, limit 1); heart muscle: 5.7 nTPM (vital, limit 1); adrenal gland: 5.6 nTPM (vital, limit 1); urinary bladder: 5.6 nTPM (protected, limit 3); duodenum: 5.5 nTPM (vital, limit 1); midbrain: 5.3 nTPM (vital, limit 1); hypothalamus: 5.2 nTPM (vital, limit 1); esophagus: 5.2 nTPM (protected, limit 3); basal ganglia: 5.1 nTPM (vital, limit 1); small intestine: 5 nTPM (vital, limit 1); colon: 5 nTPM (protected, limit 3); hippocampal formation: 4.8 nTPM (vital, limit 1); lymph node: 4.7 nTPM (protected, limit 3); lung: 4.5 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); cerebral cortex: 4.3 nTPM (vital, limit 1); tongue: 4.2 nTPM (protected, limit 3); skeletal muscle: 4.1 nTPM (vital, limit 1); smooth muscle: 4.1 nTPM (vital, limit 1); cerebellum: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); bone marrow: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF717,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000227151,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,PRR20D,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000227234,True,compatible,,True,True,True,,0.35,0.288545,0.25,0,3,partial,0.3,1,0.6,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPANXB1,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000227488,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GAGE12D,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1038/ncomms10499;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000227868,True,compatible,,True,True,True,,0.342629,0.296301,0.242629,0,80,unavailable,0.6,0.3,0.6,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,appendix; lymph node; skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX46,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000228075,True,compatible,,True,True,True,,0.35,0.3,0.249628,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BOD1L2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000228372,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,SMIM10L2B-AS1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive noncoding,False,False,False,False,False,unchanged,
ENSG00000228517,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT47A7,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000228567,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,VN1R4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000228836,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"basal ganglia: 51.0204% (minimum 75%, Missing); pituitary gland: 72.4638% (minimum 75%, Missing)",0.35,0.3,-0.239796,0,1,partial,4.8,0.1,0.1,"basal ganglia: 4.8 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,False,CT45A paralog target with basal-ganglia RNA signal; keep explicit clinical tier while excluding from strict defaults.,False,CT45A paralog target with basal-ganglia RNA signal; keep explicit clinical tier while excluding from strict defaults.,False,,,CT45A5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000228927,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0.2,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TSPY3,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000229292,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"amygdala: 66.6667% (minimum 75%, Missing); liver: 25.0000% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); spleen: 40.0000% (minimum 65%, Missing)",-0.25,0.3,-0.5,0,80,unavailable,0.6,0,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,RFPL4AL1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000229549,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TSPY8,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000229665,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,PRR20C,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000229676,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 43.1818% (minimum 75%, Missing)",0.0807692,0.163636,-0.318182,0,80,unavailable,2.5,0.3,0.7,"bone marrow: 2.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF492,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000229894,True,compatible,,True,True,True,,0.342187,0.3,0.219466,0,80,unavailable,0.4,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GK3,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Bruggeman 2018;Carter 2023;Gong 2021 · reproductive coding;Jamin 2021,False,True,True,True,True,gained,selectivity_revised
ENSG00000229937,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRPS1L1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000229972,True,compatible,,True,True,True,,0.35,0.3,0.246124,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,IQCF3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000230031,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,POTEB2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000230054,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.344003,0.298494,0.245495,0,80,unavailable,0.3,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TEX53,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000230178,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR4F3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000230246,False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.172078,9,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA31C1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000230268,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,SSU72L6,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000230301,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR5H6,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000230347,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT47A8,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000230522,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,MBD3L2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000230594,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT47A4,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000230601,True,compatible,,True,True,True,,0.35,0.3,0.242278,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX48,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · strict;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000231256,True,compatible,,True,True,True,,0.35,0.3,0.227273,0,3,partial,0.5,0.1,0.3,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP97D1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000231887,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"salivary gland: 20.0000% (minimum 70%, Missing)",0.327853,-0.5,0.187908,0,80,unavailable,3.8,229.6,1.3,"salivary gland: 229.6 nTPM (protected, limit 3); esophagus: 10.7 nTPM (protected, limit 3); pituitary gland: 3.8 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.4 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); kidney: 1.2 nTPM (vital, limit 1); cerebellum: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRH1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000231924,True,compatible,,True,True,True,,0.35,0.3,0.249604,0,2,partial,0.5,0.4,0.6,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PSG1,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",True,True,True,True,True,unchanged,
ENSG00000231989,True,compatible,,True,True,True,,0.35,0.3,0.245327,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PPP1R2B,current_adaptive,True,False,True,True,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Gong 2021 · reproductive coding,True,True,True,True,True,unchanged,
ENSG00000232030,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEB6B,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,True,True,True,True,True,gained,admission_only
ENSG00000232040,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.191584,0.204255,0.0673077,0,80,unavailable,1.9,0.9,1.6,"cerebellum: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SCAND3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000232113,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TEX50,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000232423,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRAMEF6,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000232948,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,DEFB130A,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000233050,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,DEFB130B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000233056,False,excluded,rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,,0.341957,0.297305,0.239967,9,80,unavailable,1.5,0.4,1.2,"retina: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ERVH48-1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive noncoding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000233412,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR5H15,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000233436,True,compatible,,True,True,True,,0.263043,0.3,0.163043,0,80,unavailable,0.2,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BTBD18,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000233701,True,compatible,,True,True,True,,0.35,0.3,0.15,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRR23C,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding;Wang 2016,False,True,True,True,True,gained,selectivity_revised
ENSG00000233802,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TRIM49D2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000233803,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0,0.2,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TSPY4,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000233917,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,POTEB,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000234068,True,compatible,,True,True,True,,0.342674,0.3,0.246324,0,2,partial,0.2,0.3,0.5,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PAGE2,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Carter 2023;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000234186,True,compatible,,True,True,True,,0.35,0.3,0.248885,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C16orf82,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000234278,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,PRR20E,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000234284,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"cerebellum: 57.1429% (minimum 75%, Missing); heart muscle: 69.7674% (minimum 75%, Missing); kidney: 73.1707% (minimum 75%, Missing); lymph node: 66.6667% (minimum 70%, Missing); pituitary gland: 70.5882% (minimum 75%, Missing); retina: 46.5116% (minimum 75%, Missing); skeletal muscle: 74.0741% (minimum 75%, Uncertain); skin: 63.8298% (minimum 65%, Missing); smooth muscle: 73.1707% (minimum 75%, Uncertain); thymus: 64.5161% (minimum 65%, Missing); thyroid gland: 62.5000% (minimum 65%, Missing); tongue: 66.6667% (minimum 70%, Missing)",-0.025,-0.0333333,-0.284884,0,6,partial,6.9,3,3.6,"retina: 6.9 nTPM (vital, limit 1); cerebellum: 4.5 nTPM (vital, limit 1); heart muscle: 2.6 nTPM (vital, limit 1); pituitary gland: 2.5 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); cerebral cortex: 2 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); pancreas: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); adrenal gland: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / neuropil: Medium (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lymph node / germinal center cells: Medium (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: Medium (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: Medium (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / chondrocytes: Medium (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: High (Uncertain),49,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF879,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000234289,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"adipose tissue: 60.8696% (minimum 65%, Missing); adrenal gland: 70.0000% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); esophagus: 51.8519% (minimum 70%, Missing); heart muscle: 73.6842% (minimum 75%, Missing); liver: 42.4242% (minimum 75%, Missing); lung: 60.8696% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing); pancreas: 58.3333% (minimum 75%, Missing); small intestine: 63.6364% (minimum 75%, Missing); spleen: 48.2759% (minimum 65%, Missing)",-0.167241,-0.2,-0.325758,0,3,partial,1.9,1.4,1.5,"liver: 1.9 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Medium (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Medium (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,H2BC12L,current_adaptive,False,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000234409,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.313054,0.282412,0.0578512,0,80,unavailable,9.3,0.7,1.5,"pituitary gland: 9.3 nTPM (vital, limit 1); hypothalamus: 2.9 nTPM (vital, limit 1); cerebellum: 2.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC188,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,False,False,False,False,unchanged,
ENSG00000234414,True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RBMY1A1,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000234469,True,compatible,,True,True,True,,0.238889,0.241176,0.0119048,0,80,unavailable,0.5,0.1,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CLDN34,current_adaptive,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,True,True,True,True,gained,selectivity_revised
ENSG00000234511,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.333514,0.289573,0.215326,0,80,unavailable,7.5,2.2,3.5,"spinal cord: 7.5 nTPM (vital, limit 1); bone marrow: 6.6 nTPM (vital, limit 1); lung: 4.8 nTPM (vital, limit 1); midbrain: 2.3 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C5orf58,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000234776,True,compatible,,True,True,True,,0.35,0.294393,0.25,0,80,unavailable,0,0.3,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FREY1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000234828,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.23617,0.25,0,80,unavailable,0,0.3,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,IQCM,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000235608,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.0833333,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,NKX1-1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000235631,True,compatible,,True,True,True,,0.345842,0.291718,0.239669,0,80,unavailable,0.5,0.4,0.2,,,0,not_established,required,in_situ_inflammation_review;local_control_not_established;persistent_salivary_dysfunction_review,gallbladder; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RNF148,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000235699,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CXorf51B,current_adaptive,True,False,True,True,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000236027,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PATE3,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000236032,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 60.0000% (minimum 75%, Missing); choroid plexus: 75.0000% (minimum 75%, Missing); retina: 75.0000% (minimum 75%, Missing)",0.1,0.3,-0.15,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR5H14,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000236126,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT47A3,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000236362,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.23381,0,4,partial,1.7,8.3,0,"stomach: 8.3 nTPM (protected, limit 6); retina: 1.7 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GAGE12F,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000236371,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT47A1,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000236396,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,SLC35G4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000236424,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0.1,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TSPY10,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000236446,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT47B1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000236737,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.341361,0.282168,0.228678,0,80,unavailable,3,2.5,1.2,"basal ganglia: 3 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); cerebellum: 1.4 nTPM (vital, limit 1); duodenum: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GAGE12B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000236761,True,compatible,,True,True,True,,0.337805,0.275904,0.237805,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CTAGE9,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000236980,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CIMIP7,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000237136,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C4orf51,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000237247,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MBD3L5,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000237452,True,compatible,,True,True,True,,0.35,0.3,0.209459,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MEIOSIN,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000237521,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR7E24,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000237524,True,compatible,,True,True,True,,0.35,0.3,0.244881,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX51,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding,True,True,True,True,True,unchanged,
ENSG00000237671,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GAGE12C,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000237957,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT47A5,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000238074,False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna,True,True,True,,0.35,0.286395,0.25,9,2,partial,0,0.2,0.1,,adrenal gland / glandular cells: Low (Supported); stomach 1 / glandular cells: Low (Supported); stomach 2 / glandular cells: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TSPY9,current_adaptive,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict,False,False,False,False,False,unchanged,
ENSG00000238083,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.255405,0.217808,0.155405,0,9,partial,0.7,0.6,0.7,,small intestine / enterocytes - Gradient: Ascending (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRRC37A2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000238205,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,MPC1L,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000238269,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.346377,0.289209,0.246377,0,2,partial,4,0.6,0.7,"bone marrow: 4 nTPM (vital, limit 3)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PAGE2B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000239306,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 62.6973% (minimum 65%, Missing); adrenal gland: 58.5007% (minimum 75%, Missing); amygdala: 65.1267% (minimum 75%, Missing); basal ganglia: 62.0739% (minimum 75%, Missing); bone marrow: 57.5000% (minimum 75%, Missing); cerebellum: 47.8118% (minimum 75%, Missing); cerebral cortex: 60.5263% (minimum 75%, Missing); choroid plexus: 60.4426% (minimum 75%, Missing); colon: 60.6103% (minimum 70%, Missing); duodenum: 74.1935% (minimum 75%, Missing); esophagus: 56.9752% (minimum 70%, Missing); heart muscle: 57.5758% (minimum 75%, Missing); hippocampal formation: 64.6450% (minimum 75%, Missing); hypothalamus: 64.9331% (minimum 75%, Missing); kidney: 47.0905% (minimum 75%, Missing); liver: 52.5240% (minimum 75%, Missing); lung: 62.3395% (minimum 75%, Missing); lymph node: 61.2903% (minimum 70%, Missing); midbrain: 66.3126% (minimum 75%, Missing); pancreas: 56.9010% (minimum 75%, Missing); pituitary gland: 56.5330% (minimum 75%, Missing); retina: 55.7398% (minimum 75%, Missing); salivary gland: 64.0762% (minimum 70%, Missing); skeletal muscle: 60.4426% (minimum 75%, Missing); skin: 61.3764% (minimum 65%, Missing); small intestine: 60.6944% (minimum 75%, Missing); smooth muscle: 74.3197% (minimum 75%, Missing); spinal cord: 67.4383% (minimum 75%, Missing); spleen: 52.5872% (minimum 65%, Missing); stomach: 59.9451% (minimum 70%, Missing); thymus: 63.6099% (minimum 65%, Missing); thyroid gland: 61.2903% (minimum 65%, Missing); urinary bladder: 59.7811% (minimum 70%, Missing)",-0.124128,-0.130248,-0.279095,0,5,partial,49.1,33,39.4,"kidney: 49.1 nTPM (vital, limit 1); cerebellum: 47.7 nTPM (vital, limit 1); liver: 39.5 nTPM (vital, limit 1); spleen: 39.4 nTPM (manageable, limit 5); retina: 34.7 nTPM (vital, limit 1); pituitary gland: 33.6 nTPM (vital, limit 1); pancreas: 33.1 nTPM (vital, limit 1); esophagus: 33 nTPM (protected, limit 3); bone marrow: 32.3 nTPM (vital, limit 1); heart muscle: 32.2 nTPM (vital, limit 1); adrenal gland: 31 nTPM (vital, limit 1); urinary bladder: 29.4 nTPM (protected, limit 3); stomach: 29.2 nTPM (protected, limit 3); choroid plexus: 28.6 nTPM (vital, limit 1); skeletal muscle: 28.6 nTPM (vital, limit 1); cerebral cortex: 28.5 nTPM (vital, limit 1); colon: 28.4 nTPM (protected, limit 3); small intestine: 28.3 nTPM (vital, limit 1); lymph node: 27.6 nTPM (protected, limit 3); thyroid gland: 27.6 nTPM (manageable, limit 5); skin: 27.5 nTPM (manageable, limit 5); basal ganglia: 26.7 nTPM (vital, limit 1); lung: 26.4 nTPM (vital, limit 1); adipose tissue: 26 nTPM (manageable, limit 5); thymus: 25 nTPM (manageable, limit 5); salivary gland: 24.5 nTPM (protected, limit 3); hippocampal formation: 23.9 nTPM (vital, limit 1); hypothalamus: 23.6 nTPM (vital, limit 1); amygdala: 23.4 nTPM (vital, limit 1); midbrain: 22.2 nTPM (vital, limit 1); spinal cord: 21.1 nTPM (vital, limit 1); rectum: 17.6 nTPM (protected, limit 3); parathyroid gland: 16.9 nTPM (protected, limit 3); duodenum: 15.2 nTPM (vital, limit 1); smooth muscle: 15.1 nTPM (vital, limit 1); tongue: 11.1 nTPM (protected, limit 3)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / bowman's capsule: Low (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: Low (Supported); kidney / distal tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); lung / alveolar cells type I: High (Supported); lung / alveolar cells type II: High (Supported); lung / endothelial cells: High (Supported); lung / macrophages: Low (Supported); lymph node / germinal center cells: High (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: Low (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 1 / Langerhans: Medium (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); soft tissue 2 / fibroblasts: Medium (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),59,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RBM14,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000239388,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 50.0000% (minimum 65%, Missing); adrenal gland: 66.6667% (minimum 75%, Missing); amygdala: 75.0000% (minimum 75%, Missing); basal ganglia: 75.0000% (minimum 75%, Missing); bone marrow: 24.0000% (minimum 75%, Missing); cerebellum: 54.5455% (minimum 75%, Missing); cerebral cortex: 60.0000% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); duodenum: 75.0000% (minimum 75%, Missing); esophagus: 60.0000% (minimum 70%, Missing); heart muscle: 13.9535% (minimum 75%, Missing); hippocampal formation: 75.0000% (minimum 75%, Missing); hypothalamus: 66.6667% (minimum 75%, Missing); kidney: 75.0000% (minimum 75%, Missing); liver: 66.6667% (minimum 75%, Missing); lung: 54.5455% (minimum 75%, Missing); lymph node: 46.1538% (minimum 70%, Missing); midbrain: 66.6667% (minimum 75%, Missing); pancreas: 28.5714% (minimum 75%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 27.2727% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing); skeletal muscle: 2.1661% (minimum 75%, Missing); skin: 42.8571% (minimum 65%, Missing); small intestine: 54.5455% (minimum 75%, Missing); spinal cord: 66.6667% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 54.5455% (minimum 70%, Missing); thyroid gland: 60.0000% (minimum 65%, Missing); tongue: 3.3520% (minimum 70%, Missing); urinary bladder: 60.0000% (minimum 70%, Missing)",-0.221429,-0.66648,-0.728339,0,80,unavailable,27.1,17.3,0.8,"skeletal muscle: 27.1 nTPM (vital, limit 1); tongue: 17.3 nTPM (protected, limit 3); heart muscle: 3.7 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); retina: 1.6 nTPM (vital, limit 1); pancreas: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ASB14,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000239389,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 33.3333% (minimum 75%, Missing); basal ganglia: 31.2500% (minimum 75%, Missing); cerebellum: 21.7391% (minimum 75%, Missing); cerebral cortex: 26.3158% (minimum 75%, Missing); hippocampal formation: 31.2500% (minimum 75%, Missing); hypothalamus: 38.4615% (minimum 75%, Missing); liver: 71.4286% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 45.4545% (minimum 75%, Missing); parathyroid gland: 12.8205% (minimum 70%, Missing); pituitary gland: 55.5556% (minimum 75%, Missing); retina: 31.2500% (minimum 75%, Missing); spinal cord: 55.5556% (minimum 75%, Missing)",0.0642857,-0.571795,-0.532609,0,80,unavailable,1.8,3.4,0.2,"parathyroid gland: 3.4 nTPM (protected, limit 3); cerebellum: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); retina: 1.1 nTPM (vital, limit 1)",,0,not_established,required,in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHA13,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000239590,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR1J4,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000239605,True,compatible,,True,True,True,,0.343056,0.3,0.243056,0,4,partial,0.1,0.2,0.1,,,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,STPG4,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.18632/oncotarget.21715,Chang 2019 · TGCT;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000239620,False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRR20G,current_adaptive,True,False,False,False,10.1136/jitc-2023-007935,Carter 2023,False,False,False,False,False,unchanged,
ENSG00000239704,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 56.8773% (minimum 75%, Missing); amygdala: 68.6099% (minimum 75%, Missing); basal ganglia: 61.2000% (minimum 75%, Missing); cerebellum: 57.9545% (minimum 75%, Missing); cerebral cortex: 66.2338% (minimum 75%, Uncertain); choroid plexus: 50.4950% (minimum 75%, Missing); colon: 69.5455% (minimum 70%, Missing); hippocampal formation: 67.1053% (minimum 75%, Missing); hypothalamus: 60.2362% (minimum 75%, Missing); kidney: 59.0734% (minimum 75%, Uncertain); liver: 70.1835% (minimum 75%, Missing); midbrain: 69.2308% (minimum 75%, Missing); pancreas: 55.8394% (minimum 75%, Uncertain); pituitary gland: 33.7004% (minimum 75%, Missing); retina: 72.1698% (minimum 75%, Missing); salivary gland: 61.4458% (minimum 70%, Missing); skin: 60.9562% (minimum 65%, Uncertain); small intestine: 67.1053% (minimum 75%, Missing); spinal cord: 70.8333% (minimum 75%, Missing); spleen: 59.5331% (minimum 65%, Uncertain); stomach: 68.0000% (minimum 70%, Missing); thyroid gland: 51.3423% (minimum 65%, Missing)",-0.136577,-0.0855422,-0.412996,0,2,partial,30.1,9.6,14.5,"pituitary gland: 30.1 nTPM (vital, limit 1); choroid plexus: 15 nTPM (vital, limit 1); thyroid gland: 14.5 nTPM (manageable, limit 5); pancreas: 12.1 nTPM (vital, limit 1); adrenal gland: 11.6 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); kidney: 10.6 nTPM (vital, limit 1); spleen: 10.4 nTPM (manageable, limit 5); hypothalamus: 10.1 nTPM (vital, limit 1); skin: 9.8 nTPM (manageable, limit 5); basal ganglia: 9.7 nTPM (vital, limit 1); salivary gland: 9.6 nTPM (protected, limit 3); cerebral cortex: 7.8 nTPM (vital, limit 1); hippocampal formation: 7.5 nTPM (vital, limit 1); small intestine: 7.5 nTPM (vital, limit 1); stomach: 7.2 nTPM (protected, limit 3); amygdala: 7 nTPM (vital, limit 1); midbrain: 6.8 nTPM (vital, limit 1); colon: 6.7 nTPM (protected, limit 3); esophagus: 6.5 nTPM (protected, limit 3); liver: 6.5 nTPM (vital, limit 1); spinal cord: 6.3 nTPM (vital, limit 1); retina: 5.9 nTPM (vital, limit 1); urinary bladder: 5.4 nTPM (protected, limit 3); lung: 5 nTPM (vital, limit 1); heart muscle: 3.2 nTPM (vital, limit 1); bone marrow: 3 nTPM (vital, limit 1); smooth muscle: 1.1 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); duodenum / glandular cells: Medium (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / macrophages: Medium (Uncertain); nasopharynx / respiratory epithelial cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CDRT4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000239789,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 55.2885% (minimum 60%, Approved); adrenal gland: 46.7480% (minimum 75%, Missing); amygdala: 46.5587% (minimum 75%, Missing); basal ganglia: 45.4545% (minimum 75%, Missing); bone marrow: 53.7383% (minimum 75%, Missing); cerebellum: 47.9167% (minimum 75%, Missing); cerebral cortex: 41.6667% (minimum 75%, Missing); choroid plexus: 60.5263% (minimum 75%, Missing); colon: 47.7178% (minimum 70%, Missing); duodenum: 57.2139% (minimum 75%, Missing); esophagus: 46.7480% (minimum 70%, Missing); heart muscle: 37.2168% (minimum 75%, Missing); hippocampal formation: 46.3710% (minimum 75%, Missing); hypothalamus: 47.9167% (minimum 75%, Missing); kidney: 41.3669% (minimum 75%, Missing); liver: 34.7432% (minimum 75%, Missing); lung: 63.1868% (minimum 75%, Missing); lymph node: 56.6502% (minimum 70%, Missing); midbrain: 54.2453% (minimum 75%, Missing); pancreas: 46.5587% (minimum 75%, Missing); parathyroid gland: 55.2885% (minimum 65%, Approved); pituitary gland: 58.6735% (minimum 75%, Missing); rectum: 54.7619% (minimum 70%, Missing); retina: 68.0473% (minimum 75%, Missing); salivary gland: 56.9307% (minimum 70%, Missing); skeletal muscle: 26.6204% (minimum 75%, Missing); skin: 58.9744% (minimum 65%, Missing); small intestine: 56.3725% (minimum 75%, Missing); smooth muscle: 56.0976% (minimum 75%, Missing); spinal cord: 59.8958% (minimum 75%, Missing); spleen: 53.7383% (minimum 60%, Approved); stomach: 50.6608% (minimum 70%, Missing); thymus: 56.3725% (minimum 65%, Missing); thyroid gland: 59.2784% (minimum 65%, Missing); tongue: 26.8692% (minimum 70%, Missing); urinary bladder: 52.0362% (minimum 70%, Missing)",-0.0862745,-0.431308,-0.483796,0,4,partial,31.7,31.3,9.9,"skeletal muscle: 31.7 nTPM (vital, limit 1); tongue: 31.3 nTPM (protected, limit 3); liver: 21.6 nTPM (vital, limit 1); heart muscle: 19.4 nTPM (vital, limit 1); kidney: 16.3 nTPM (vital, limit 1); cerebral cortex: 16.1 nTPM (vital, limit 1); basal ganglia: 13.8 nTPM (vital, limit 1); hippocampal formation: 13.3 nTPM (vital, limit 1); amygdala: 13.2 nTPM (vital, limit 1); pancreas: 13.2 nTPM (vital, limit 1); adrenal gland: 13.1 nTPM (vital, limit 1); esophagus: 13.1 nTPM (protected, limit 3); colon: 12.6 nTPM (protected, limit 3); cerebellum: 12.5 nTPM (vital, limit 1); hypothalamus: 12.5 nTPM (vital, limit 1); stomach: 11.2 nTPM (protected, limit 3); urinary bladder: 10.6 nTPM (protected, limit 3); bone marrow: 9.9 nTPM (vital, limit 1); midbrain: 9.7 nTPM (vital, limit 1); rectum: 9.5 nTPM (protected, limit 3); parathyroid gland: 9.3 nTPM (protected, limit 4); smooth muscle: 9 nTPM (vital, limit 1); small intestine: 8.9 nTPM (vital, limit 1); thymus: 8.9 nTPM (manageable, limit 5); lymph node: 8.8 nTPM (protected, limit 3); salivary gland: 8.7 nTPM (protected, limit 3); duodenum: 8.6 nTPM (vital, limit 1); pituitary gland: 8.1 nTPM (vital, limit 1); skin: 8 nTPM (manageable, limit 5); thyroid gland: 7.9 nTPM (manageable, limit 5); spinal cord: 7.7 nTPM (vital, limit 1); choroid plexus: 7.5 nTPM (vital, limit 1); lung: 6.7 nTPM (vital, limit 1); retina: 5.4 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / glandular cells: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); lung / macrophages: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); rectum / glandular cells: Low (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MRPS17,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000239810,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRAMEF11,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000239886,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"skin: 0.3145% (minimum 65%, Missing)",-0.646855,0.3,0.25,0,80,unavailable,0,0,31.7,"skin: 31.7 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KRTAP9-2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000239887,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 45.9302% (minimum 75%, Missing); cerebellum: 54.8611% (minimum 75%, Missing); choroid plexus: 71.1712% (minimum 75%, Missing); colon: 46.7456% (minimum 70%, Missing); duodenum: 59.3985% (minimum 75%, Missing); esophagus: 66.3866% (minimum 70%, Missing); heart muscle: 70.5357% (minimum 75%, Missing); hypothalamus: 69.2982% (minimum 75%, Missing); kidney: 41.7989% (minimum 75%, Missing); liver: 26.9625% (minimum 75%, Missing); midbrain: 73.8318% (minimum 75%, Missing); pancreas: 69.2982% (minimum 75%, Missing); parathyroid gland: 66.9492% (minimum 70%, Missing); pituitary gland: 45.1429% (minimum 75%, Missing); rectum: 45.6647% (minimum 70%, Missing); retina: 53.7415% (minimum 75%, Missing); salivary gland: 48.7654% (minimum 70%, Missing); skin: 60.7692% (minimum 65%, Missing); small intestine: 50.6410% (minimum 75%, Missing); spinal cord: 70.5357% (minimum 75%, Missing); stomach: 48.4663% (minimum 70%, Missing)",-0.0423077,-0.243353,-0.480375,0,2,partial,21.4,9.4,5.1,"liver: 21.4 nTPM (vital, limit 1); kidney: 11 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); rectum: 9.4 nTPM (protected, limit 3); adrenal gland: 9.3 nTPM (vital, limit 1); colon: 9 nTPM (protected, limit 3); stomach: 8.4 nTPM (protected, limit 3); salivary gland: 8.3 nTPM (protected, limit 3); small intestine: 7.7 nTPM (vital, limit 1); retina: 6.8 nTPM (vital, limit 1); cerebellum: 6.5 nTPM (vital, limit 1); duodenum: 5.4 nTPM (vital, limit 1); skin: 5.1 nTPM (manageable, limit 5); esophagus: 4 nTPM (protected, limit 3); parathyroid gland: 3.9 nTPM (protected, limit 3); hypothalamus: 3.5 nTPM (vital, limit 1); pancreas: 3.5 nTPM (vital, limit 1); heart muscle: 3.3 nTPM (vital, limit 1); spinal cord: 3.3 nTPM (vital, limit 1); choroid plexus: 3.2 nTPM (vital, limit 1); midbrain: 2.8 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); bone marrow: 2 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); basal ganglia: 1.7 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Medium (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / glial cells: Low (Approved); cerebral cortex / neuronal cells: Medium (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: High (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: High (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: High (Approved); kidney / cells in glomeruli: Medium (Approved); kidney / cells in tubules: High (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Medium (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Medium (Approved); lymph node / non-germinal center cells: Low (Approved); nasopharynx / respiratory epithelial cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: High (Approved); salivary gland / glandular cells: High (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: High (Approved); smooth muscle / smooth muscle cells: Medium (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: High (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C1orf226,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000240021,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.348259,0.297391,0.237091,0,3,partial,1.8,1.4,1.5,"retina: 1.5 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX35,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000240204,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.344205,0.250911,0.173136,0,80,unavailable,10,6.2,0.7,"basal ganglia: 10 nTPM (vital, limit 1); cerebral cortex: 6.6 nTPM (vital, limit 1); parathyroid gland: 6.2 nTPM (protected, limit 3); pituitary gland: 5.9 nTPM (vital, limit 1); amygdala: 5 nTPM (vital, limit 1); hippocampal formation: 4.9 nTPM (vital, limit 1); hypothalamus: 4.7 nTPM (vital, limit 1); midbrain: 2.2 nTPM (vital, limit 1); pancreas: 2.2 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SMKR1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000240303,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 38.0952% (minimum 50%, Enhanced); adrenal gland: 56.4706% (minimum 60%, Enhanced); amygdala: 73.2824% (minimum 75%, Missing); basal ganglia: 69.5652% (minimum 75%, Missing); bone marrow: 55.4913% (minimum 60%, Enhanced); cerebellum: 69.5652% (minimum 75%, Missing); cerebral cortex: 70.0730% (minimum 75%, Missing); choroid plexus: 17.2043% (minimum 75%, Missing); colon: 56.4706% (minimum 70%, Missing); duodenum: 36.6412% (minimum 75%, Missing); heart muscle: 39.1837% (minimum 75%, Missing); hippocampal formation: 73.2824% (minimum 75%, Missing); hypothalamus: 75.0000% (minimum 75%, Missing); kidney: 13.3891% (minimum 75%, Missing); liver: 8.7193% (minimum 75%, Missing); midbrain: 70.5882% (minimum 75%, Missing); pancreas: 54.8571% (minimum 60%, Enhanced); parathyroid gland: 52.7473% (minimum 55%, Enhanced); pituitary gland: 50.2618% (minimum 75%, Missing); retina: 45.9330% (minimum 75%, Missing); skeletal muscle: 70.0730% (minimum 75%, Missing); small intestine: 38.5542% (minimum 75%, Missing); spinal cord: 67.1329% (minimum 75%, Missing); stomach: 67.6056% (minimum 70%, Missing)",-0.119048,-0.135294,-0.662807,0,12,partial,100.5,8.6,15.6,"liver: 100.5 nTPM (vital, limit 1); kidney: 62.1 nTPM (vital, limit 1); choroid plexus: 46.2 nTPM (vital, limit 1); duodenum: 16.6 nTPM (vital, limit 1); small intestine: 15.3 nTPM (vital, limit 1); heart muscle: 14.9 nTPM (vital, limit 1); retina: 11.3 nTPM (vital, limit 1); pituitary gland: 9.5 nTPM (vital, limit 1); pancreas: 7.9 nTPM (vital, limit 6); bone marrow: 7.7 nTPM (vital, limit 6); adrenal gland: 7.4 nTPM (vital, limit 6); colon: 7.4 nTPM (protected, limit 3); smooth muscle: 6.1 nTPM (vital, limit 6); spinal cord: 4.7 nTPM (vital, limit 1); stomach: 4.6 nTPM (protected, limit 3); cerebellum: 4.2 nTPM (vital, limit 1); basal ganglia: 4.2 nTPM (vital, limit 1); cerebral cortex: 4.1 nTPM (vital, limit 1); skeletal muscle: 4.1 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.5 nTPM (vital, limit 1); rectum: 3.3 nTPM (protected, limit 3); hypothalamus: 3.2 nTPM (vital, limit 1)",caudate / neuronal cells: Low (Enhanced); cerebellum / granular cells - cytoplasm/membrane: Medium (Enhanced); cerebellum / processes in granular layer: High (Enhanced); cerebellum / processes in white matter: High (Enhanced); cerebellum / Purkinje cells - cytoplasm/membrane: Low (Enhanced); cerebellum / Purkinje cells - dendrites: Medium (Enhanced); cerebellum / white matter cells - cytoplasm/membrane: High (Enhanced); cerebral cortex / neuronal cells: Low (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / enterocytes - Microvilli: Medium (Enhanced); heart muscle / cardiomyocytes: Medium (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Low (Enhanced); kidney / proximal tubules (cell body): Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); rectum / mucosal lymphoid cells: Low (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); small intestine / endocrine cells: Medium (Enhanced); small intestine / enterocytes: Medium (Enhanced); small intestine / enterocytes - Gradient: Ascending (Enhanced); stomach 1 / glandular cells: Low (Enhanced),93,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / enterocytes - Microvilli; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ACAD11,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000240445,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,"cerebral cortex: 67.1642% (minimum 75%, Missing); retina: 72.5806% (minimum 75%, Missing); smooth muscle: 73.7705% (minimum 75%, Missing)",0.0117647,0.0258065,-0.0783582,9,80,unavailable,2.2,1.7,2.3,"cerebral cortex: 2.2 nTPM (vital, limit 1); retina: 1.7 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); heart muscle: 1.5 nTPM (vital, limit 1); adrenal gland: 1.1 nTPM (vital, limit 1); skeletal muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FOXO3B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000240563,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"colon: 68.2927% (minimum 70%, Missing)",0.27562,-0.0170732,0.138889,0,80,unavailable,1.4,5.2,0.9,"colon: 5.2 nTPM (protected, limit 3); lung: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,L1TD1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Jamin 2021;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000240682,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 54.0609% (minimum 65%, Missing); adrenal gland: 61.5607% (minimum 75%, Missing); amygdala: 67.1924% (minimum 75%, Missing); basal ganglia: 66.5625% (minimum 75%, Missing); bone marrow: 29.7071% (minimum 75%, Missing); cerebellum: 64.7416% (minimum 75%, Missing); cerebral cortex: 62.4633% (minimum 75%, Missing); choroid plexus: 67.4051% (minimum 75%, Missing); colon: 50.4739% (minimum 70%, Missing); duodenum: 58.8398% (minimum 75%, Missing); esophagus: 49.7664% (minimum 70%, Missing); heart muscle: 50.8353% (minimum 75%, Missing); hippocampal formation: 68.2692% (minimum 75%, Missing); hypothalamus: 67.8344% (minimum 75%, Missing); kidney: 59.3315% (minimum 75%, Missing); liver: 66.7712% (minimum 75%, Missing); lung: 60.8571% (minimum 75%, Missing); lymph node: 40.5714% (minimum 70%, Missing); midbrain: 66.9811% (minimum 75%, Missing); pancreas: 58.1967% (minimum 75%, Missing); parathyroid gland: 66.3551% (minimum 70%, Missing); pituitary gland: 71.4765% (minimum 75%, Missing); rectum: 56.6489% (minimum 70%, Missing); retina: 67.8344% (minimum 75%, Missing); salivary gland: 59.6639% (minimum 70%, Missing); skeletal muscle: 38.7978% (minimum 75%, Missing); skin: 51.9512% (minimum 65%, Missing); small intestine: 57.5676% (minimum 75%, Missing); smooth muscle: 52.2059% (minimum 75%, Missing); spinal cord: 66.3551% (minimum 75%, Missing); spleen: 54.4757% (minimum 65%, Missing); stomach: 59.6639% (minimum 70%, Missing); thymus: 49.0783% (minimum 65%, Missing); thyroid gland: 59.6639% (minimum 65%, Missing); tongue: 51.0791% (minimum 70%, Missing); urinary bladder: 54.6154% (minimum 70%, Missing)",-0.159217,-0.294286,-0.452929,0,4,partial,50.4,31.2,22.1,"bone marrow: 50.4 nTPM (vital, limit 1); skeletal muscle: 33.6 nTPM (vital, limit 1); lymph node: 31.2 nTPM (protected, limit 3); thymus: 22.1 nTPM (manageable, limit 5); esophagus: 21.5 nTPM (protected, limit 3); colon: 20.9 nTPM (protected, limit 3); heart muscle: 20.6 nTPM (vital, limit 1); tongue: 20.4 nTPM (protected, limit 3); skin: 19.7 nTPM (manageable, limit 5); smooth muscle: 19.5 nTPM (vital, limit 1); adipose tissue: 18.1 nTPM (manageable, limit 5); spleen: 17.8 nTPM (manageable, limit 5); urinary bladder: 17.7 nTPM (protected, limit 3); rectum: 16.3 nTPM (protected, limit 3); small intestine: 15.7 nTPM (vital, limit 1); pancreas: 15.3 nTPM (vital, limit 1); duodenum: 14.9 nTPM (vital, limit 1); kidney: 14.6 nTPM (vital, limit 1); salivary gland: 14.4 nTPM (protected, limit 3); thyroid gland: 14.4 nTPM (manageable, limit 5); stomach: 14.4 nTPM (protected, limit 3); lung: 13.7 nTPM (vital, limit 1); adrenal gland: 13.3 nTPM (vital, limit 1); cerebral cortex: 12.8 nTPM (vital, limit 1); cerebellum: 11.6 nTPM (vital, limit 1); spinal cord: 10.8 nTPM (vital, limit 1); parathyroid gland: 10.8 nTPM (protected, limit 3); basal ganglia: 10.7 nTPM (vital, limit 1); liver: 10.6 nTPM (vital, limit 1); midbrain: 10.5 nTPM (vital, limit 1); amygdala: 10.4 nTPM (vital, limit 1); choroid plexus: 10.3 nTPM (vital, limit 1); retina: 10.1 nTPM (vital, limit 1); hypothalamus: 10.1 nTPM (vital, limit 1); hippocampal formation: 9.9 nTPM (vital, limit 1); pituitary gland: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: Medium (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: Medium (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: Low (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ISY1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000240720,True,compatible,,True,True,True,,0.35,0.3,0.222789,0,4,partial,0.4,0.1,0.3,,,51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LRRD1,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000240747,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.324138,0.276614,0.223151,0,80,unavailable,5.3,4.6,5.1,"kidney: 5.3 nTPM (vital, limit 1); smooth muscle: 5.2 nTPM (vital, limit 1); thyroid gland: 5.1 nTPM (manageable, limit 5); spinal cord: 4.6 nTPM (vital, limit 1); esophagus: 4.6 nTPM (protected, limit 3); colon: 4.5 nTPM (protected, limit 3); adrenal gland: 4.5 nTPM (vital, limit 1); pancreas: 3.9 nTPM (vital, limit 1); amygdala: 3.9 nTPM (vital, limit 1); heart muscle: 3.6 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); midbrain: 3.5 nTPM (vital, limit 1); urinary bladder: 3.4 nTPM (protected, limit 3); hippocampal formation: 3.3 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); cerebral cortex: 3.2 nTPM (vital, limit 1); basal ganglia: 3.2 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); choroid plexus: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); skeletal muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KRBOX1,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,False,False,False,False,unchanged,
ENSG00000241128,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR14A2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000241149,True,compatible,,True,True,True,,0.35,0.3,0.194444,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF722,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,Gong 2021 · reproductive coding;Loriot 2025 · strict,False,True,True,True,True,gained,selectivity_revised
ENSG00000241233,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 73.6842% (minimum 75%, Missing); cerebral cortex: 73.6842% (minimum 75%, Missing); kidney: 19.4444% (minimum 75%, Missing); skin: 16.0920% (minimum 65%, Missing)",-0.48908,0.0368421,-0.555556,0,80,unavailable,5.8,0.5,7.3,"skin: 7.3 nTPM (manageable, limit 5); kidney: 5.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KRTAP5-8,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000241258,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 56.6667% (minimum 65%, Missing); adrenal gland: 53.6278% (minimum 75%, Missing); amygdala: 56.1056% (minimum 75%, Missing); basal ganglia: 55.7377% (minimum 75%, Missing); bone marrow: 31.6574% (minimum 70%, Approved); cerebellum: 53.7975% (minimum 75%, Missing); cerebral cortex: 48.8506% (minimum 75%, Missing); choroid plexus: 66.6667% (minimum 75%, Missing); colon: 48.9914% (minimum 70%, Missing); duodenum: 51.2048% (minimum 75%, Missing); esophagus: 46.8320% (minimum 65%, Approved); heart muscle: 50.2959% (minimum 75%, Missing); hippocampal formation: 57.2391% (minimum 75%, Missing); hypothalamus: 53.9683% (minimum 75%, Missing); kidney: 51.6717% (minimum 75%, Missing); liver: 39.7196% (minimum 75%, Missing); lung: 54.6624% (minimum 75%, Missing); lymph node: 51.6717% (minimum 70%, Missing); midbrain: 55.0162% (minimum 75%, Missing); pancreas: 46.0705% (minimum 75%, Missing); parathyroid gland: 45.4545% (minimum 70%, Missing); pituitary gland: 61.1511% (minimum 75%, Missing); rectum: 47.3538% (minimum 70%, Missing); retina: 55.1948% (minimum 75%, Missing); salivary gland: 52.1472% (minimum 70%, Missing); skeletal muscle: 54.4872% (minimum 75%, Missing); skin: 52.1472% (minimum 65%, Missing); small intestine: 54.3131% (minimum 75%, Missing); smooth muscle: 49.2754% (minimum 75%, Missing); spinal cord: 55.3746% (minimum 75%, Missing); spleen: 50.1475% (minimum 65%, Missing); stomach: 49.5627% (minimum 70%, Missing); thymus: 53.7975% (minimum 65%, Missing); thyroid gland: 46.7033% (minimum 65%, Missing); tongue: 56.6667% (minimum 70%, Missing); urinary bladder: 51.6717% (minimum 70%, Missing)",-0.182967,-0.245455,-0.383426,0,3,partial,36.7,20.4,19.4,"bone marrow: 36.7 nTPM (vital, limit 2); liver: 25.8 nTPM (vital, limit 1); parathyroid gland: 20.4 nTPM (protected, limit 3); pancreas: 19.9 nTPM (vital, limit 1); thyroid gland: 19.4 nTPM (manageable, limit 5); esophagus: 19.3 nTPM (protected, limit 4); rectum: 18.9 nTPM (protected, limit 3); cerebral cortex: 17.8 nTPM (vital, limit 1); colon: 17.7 nTPM (protected, limit 3); smooth muscle: 17.5 nTPM (vital, limit 1); stomach: 17.3 nTPM (protected, limit 3); spleen: 16.9 nTPM (manageable, limit 5); heart muscle: 16.8 nTPM (vital, limit 1); duodenum: 16.2 nTPM (vital, limit 1); kidney: 15.9 nTPM (vital, limit 1); lymph node: 15.9 nTPM (protected, limit 3); urinary bladder: 15.9 nTPM (protected, limit 3); skin: 15.6 nTPM (manageable, limit 5); salivary gland: 15.6 nTPM (protected, limit 3); adrenal gland: 14.7 nTPM (vital, limit 1); cerebellum: 14.6 nTPM (vital, limit 1); thymus: 14.6 nTPM (manageable, limit 5); hypothalamus: 14.5 nTPM (vital, limit 1); small intestine: 14.3 nTPM (vital, limit 1); skeletal muscle: 14.2 nTPM (vital, limit 1); lung: 14.1 nTPM (vital, limit 1); midbrain: 13.9 nTPM (vital, limit 1); retina: 13.8 nTPM (vital, limit 1); spinal cord: 13.7 nTPM (vital, limit 1); basal ganglia: 13.5 nTPM (vital, limit 1); amygdala: 13.3 nTPM (vital, limit 1); tongue: 13 nTPM (protected, limit 3); adipose tissue: 13 nTPM (manageable, limit 5); hippocampal formation: 12.7 nTPM (vital, limit 1); pituitary gland: 10.8 nTPM (vital, limit 1); choroid plexus: 8.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): High (Approved); bronchus / ciliated cells (ciliary rootlets): High (Approved); bronchus / ciliated cells (tip of cilia): High (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in granular layer: High (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / neuronal cells: Medium (Approved); cerebral cortex / neuropil: Medium (Approved); colon / endothelial cells: Low (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Medium (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Medium (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Low (Approved); lymph node / germinal center cells: Low (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): High (Approved); nasopharynx / ciliated cells (cilia axoneme): High (Approved); nasopharynx / ciliated cells (ciliary rootlets): High (Approved); nasopharynx / ciliated cells (tip of cilia): High (Approved); nasopharynx / goblet cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Medium (Approved); parathyroid gland / glandular cells: High (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Low (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Medium (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Low (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 1 / peripheral nerve: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); soft tissue 2 / peripheral nerve: Low (Approved); spleen / cells in red pulp: Low (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),63,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CRCP,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000241476,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0,0,0.2,,,54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SSX2,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1002/cam4.2223;10.1038/ncomms10499;10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;Seager 2024 · panel;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000242220,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.347984,0.294475,0.164972,0,3,partial,18.4,1.1,1,"liver: 18.4 nTPM (vital, limit 1); cerebellum: 3.8 nTPM (vital, limit 2); cerebral cortex: 3.2 nTPM (vital, limit 2); basal ganglia: 2.7 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.4 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); midbrain: 1.9 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",liver / hepatocytes: Medium (Approved),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TCP10L,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000242221,True,compatible,,True,True,True,,0.348276,0.299137,0.246129,0,80,unavailable,0.9,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PSG2,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",True,True,True,True,True,unchanged,
ENSG00000242362,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT47A2,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000242389,True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RBMY1E,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000242441,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.316777,0.173874,0.223244,0,80,unavailable,1.6,8.4,2,"colon: 8.4 nTPM (protected, limit 3); urinary bladder: 4.1 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1); kidney: 1.1 nTPM (vital, limit 1); lung: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GTF2A1L,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000242715,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.339673,0.269646,0.203566,0,80,unavailable,2.8,1.8,0.6,"bone marrow: 2.8 nTPM (vital, limit 1); retina: 2.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC169,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1371/journal.pgen.1011734,Chang 2019 · TGCT;Loriot 2025 · preferential;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000242852,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.191808,0.171345,0.0824022,0,80,unavailable,3,2.2,2.8,"retina: 3 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); kidney: 1.6 nTPM (vital, limit 1); pituitary gland: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF709,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000242875,True,compatible,,True,True,True,,0.35,0.3,0.25,0,6,partial,0,0,0,,,48,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RBMY1B,current_adaptive,True,False,True,True,10.1038/ncomms10499;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000242950,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.331413,0.277778,0.137395,0,80,unavailable,6.7,1.2,1,"retina: 6.7 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ERVW-1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);Jamin 2021;Loriot 2025 · preferential",False,False,False,False,False,unchanged,
ENSG00000243073,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRAMEF4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000243130,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0.5,0,0.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PSG11,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased",True,True,True,True,True,unchanged,
ENSG00000243137,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.121676,0.249284,0,2,partial,1,53.8,3.2,"parathyroid gland: 53.8 nTPM (protected, limit 6)",,53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PSG4,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000243543,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347704,0.29954,0.244053,0,80,unavailable,1.3,0.1,0.5,"lung: 1.3 nTPM (vital, limit 1)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,WFDC6,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000243667,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adrenal gland: 69.6429% (minimum 75%, Missing); basal ganglia: 72.2222% (minimum 75%, Missing); choroid plexus: 63.6735% (minimum 75%, Missing); duodenum: 71.8894% (minimum 75%, Missing); esophagus: 69.6429% (minimum 70%, Missing); heart muscle: 64.1975% (minimum 75%, Missing); kidney: 74.6411% (minimum 75%, Missing); lung: 73.5849% (minimum 75%, Missing); lymph node: 62.1514% (minimum 65%, Approved); rectum: 66.9528% (minimum 70%, Missing); retina: 69.9552% (minimum 75%, Missing); skeletal muscle: 58.6466% (minimum 75%, Missing); skin: 60.2317% (minimum 65%, Missing); smooth muscle: 68.4211% (minimum 70%, Approved); tongue: 64.1975% (minimum 70%, Missing)",-0.0476834,-0.0580247,-0.163534,0,2,partial,11,9.5,10.3,"skeletal muscle: 11 nTPM (vital, limit 1); skin: 10.3 nTPM (manageable, limit 5); lymph node: 9.5 nTPM (protected, limit 4); choroid plexus: 8.9 nTPM (vital, limit 1); tongue: 8.7 nTPM (protected, limit 3); heart muscle: 8.7 nTPM (vital, limit 1); thyroid gland: 8.1 nTPM (manageable, limit 5); thymus: 7.9 nTPM (manageable, limit 5); rectum: 7.7 nTPM (protected, limit 3); smooth muscle: 7.2 nTPM (vital, limit 2); parathyroid gland: 7 nTPM (protected, limit 4); adrenal gland: 6.8 nTPM (vital, limit 1); esophagus: 6.8 nTPM (protected, limit 3); retina: 6.7 nTPM (vital, limit 1); duodenum: 6.1 nTPM (vital, limit 1); salivary gland: 6.1 nTPM (protected, limit 3); basal ganglia: 6 nTPM (vital, limit 1); colon: 5.9 nTPM (protected, limit 3); stomach: 5.8 nTPM (protected, limit 3); lung: 5.6 nTPM (vital, limit 1); kidney: 5.3 nTPM (vital, limit 1); hippocampal formation: 5.2 nTPM (vital, limit 1); small intestine: 5.1 nTPM (vital, limit 1); cerebral cortex: 5.1 nTPM (vital, limit 1); liver: 5 nTPM (vital, limit 2); cerebellum: 5 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); hypothalamus: 4.7 nTPM (vital, limit 1); pituitary gland: 4.6 nTPM (vital, limit 1); spinal cord: 4.4 nTPM (vital, limit 1); amygdala: 4.4 nTPM (vital, limit 1); pancreas: 4.2 nTPM (vital, limit 1); midbrain: 4 nTPM (vital, limit 1); bone marrow: 3.6 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Approved); bone marrow / hematopoietic cells: Low (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / neuronal cells: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Medium (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Low (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); lung / macrophages: Low (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / keratinocytes: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Low (Approved); urinary bladder / urothelial cells: Medium (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAAF10,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000243710,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"choroid plexus: 62.5344% (minimum 75%, Missing)",0.341266,0.3,-0.124656,0,5,partial,13.6,0.2,1,"choroid plexus: 13.6 nTPM (vital, limit 1); lung: 2.4 nTPM (vital, limit 1); basal ganglia: 2.3 nTPM (vital, limit 1); pituitary gland: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); retina: 1.4 nTPM (vital, limit 1)",bronchus / ciliated cells (cell body): Medium (Enhanced); bronchus / ciliated cells (cilia axoneme): High (Enhanced); bronchus / ciliated cells (tip of cilia): High (Enhanced); caudate / glial cells: Low (Enhanced); lung / alveolar cells type I: High (Enhanced); lung / macrophages: Medium (Enhanced); nasopharynx / ciliated cells (cell body): Medium (Enhanced); nasopharynx / ciliated cells (cilia axoneme): Medium (Enhanced); nasopharynx / ciliated cells (tip of cilia): Medium (Enhanced),67,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CFAP57,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000243729,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR5V1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000243978,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.113636,0,4,partial,1.2,0,0.1,"hypothalamus: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RTL9,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000244057,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"esophagus: 50.0000% (minimum 70%, Missing); skin: 10.5263% (minimum 65%, Missing)",-0.544737,-0.2,0.25,0,80,unavailable,0,0.2,1.7,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review,skin; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LCE3C,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000244219,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.322263,0.282301,0.22511,0,80,unavailable,3.4,2.4,3.8,"kidney: 3.4 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); amygdala: 2.8 nTPM (vital, limit 1); pituitary gland: 2.8 nTPM (vital, limit 1); hypothalamus: 2.7 nTPM (vital, limit 1); hippocampal formation: 2.6 nTPM (vital, limit 1); basal ganglia: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.3 nTPM (vital, limit 1); spinal cord: 2.3 nTPM (vital, limit 1); adrenal gland: 1.9 nTPM (vital, limit 1); cerebellum: 1.5 nTPM (vital, limit 1); lung: 1.4 nTPM (vital, limit 1); pancreas: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); choroid plexus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TMEM225B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000244234,False,excluded,positive_ihc_outside_permitted;incomplete_routine_rna,True,True,True,,0.35,0.289362,0.25,9,5,partial,0,0.2,0,,adipose tissue / adipocytes: Low (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / basal cells: High (Uncertain); bronchus / ciliated cells (cell body): High (Uncertain); bronchus / goblet cells: High (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in molecular layer: Low (Uncertain); cerebellum / Purkinje cells: Low (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / endothelial cells: Medium (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: High (Uncertain); liver / cholangiocytes: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lung / alveolar cells: Low (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / basal cells: Medium (Uncertain); nasopharynx / ciliated cells (cell body): Low (Uncertain); nasopharynx / goblet cells: Low (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix / glandular cells; gallbladder / glandular cells; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen / cells in red pulp; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GMCL2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000244395,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RBMY1D,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000244476,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.336226,0.132558,0.233516,0,80,unavailable,0.6,7.2,0.5,"parathyroid gland: 7.2 nTPM (protected, limit 3)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; salivary gland; skin; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ERVFRD-1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000244588,True,compatible,,True,True,True,,0.35,0.3,0.178571,0,5,partial,0.8,0.1,0,,,51,not_established,required,lymphatic_and_immune_function_review,lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RAD21L1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000244624,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"skin: 20.0000% (minimum 65%, Missing)",-0.45,0.3,0.25,0,80,unavailable,0,0,0.4,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,KRTAP20-1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000244687,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 52.0292% (minimum 65%, Missing); adrenal gland: 54.0928% (minimum 75%, Missing); amygdala: 51.1981% (minimum 75%, Missing); basal ganglia: 54.4605% (minimum 75%, Missing); bone marrow: 55.8849% (minimum 75%, Missing); cerebellum: 54.6928% (minimum 75%, Missing); cerebral cortex: 45.0140% (minimum 75%, Missing); choroid plexus: 45.4288% (minimum 75%, Missing); colon: 48.8567% (minimum 70%, Missing); duodenum: 53.0190% (minimum 75%, Missing); esophagus: 48.0870% (minimum 70%, Missing); heart muscle: 51.6103% (minimum 75%, Missing); hippocampal formation: 55.6907% (minimum 75%, Missing); hypothalamus: 53.6851% (minimum 75%, Missing); kidney: 53.4612% (minimum 75%, Missing); liver: 45.8184% (minimum 75%, Missing); lung: 53.1069% (minimum 75%, Missing); lymph node: 48.9687% (minimum 70%, Missing); midbrain: 56.0315% (minimum 75%, Missing); pancreas: 50.5521% (minimum 75%, Missing); parathyroid gland: 52.0292% (minimum 70%, Missing); pituitary gland: 65.7436% (minimum 75%, Missing); rectum: 51.9449% (minimum 70%, Missing); retina: 58.3789% (minimum 75%, Missing); salivary gland: 54.2760% (minimum 70%, Missing); skeletal muscle: 43.0490% (minimum 75%, Missing); skin: 50.8730% (minimum 65%, Missing); small intestine: 55.9825% (minimum 75%, Missing); smooth muscle: 47.5167% (minimum 75%, Missing); spinal cord: 64.1000% (minimum 75%, Missing); spleen: 55.9337% (minimum 65%, Missing); stomach: 54.1385% (minimum 70%, Missing); thymus: 51.9870% (minimum 65%, Missing); thyroid gland: 56.9778% (minimum 65%, Missing); tongue: 48.4505% (minimum 70%, Missing); urinary bladder: 49.5363% (minimum 70%, Missing)",-0.14127,-0.21913,-0.31951,0,80,unavailable,84.8,69.2,61.9,"skeletal muscle: 84.8 nTPM (vital, limit 1); cerebral cortex: 78.3 nTPM (vital, limit 1); choroid plexus: 77 nTPM (vital, limit 1); liver: 75.8 nTPM (vital, limit 1); smooth muscle: 70.8 nTPM (vital, limit 1); esophagus: 69.2 nTPM (protected, limit 3); tongue: 68.2 nTPM (protected, limit 3); colon: 67.1 nTPM (protected, limit 3); lymph node: 66.8 nTPM (protected, limit 3); urinary bladder: 65.3 nTPM (protected, limit 3); pancreas: 62.7 nTPM (vital, limit 1); skin: 61.9 nTPM (manageable, limit 5); amygdala: 61.1 nTPM (vital, limit 1); heart muscle: 60.1 nTPM (vital, limit 1); rectum: 59.3 nTPM (protected, limit 3); thymus: 59.2 nTPM (manageable, limit 5); parathyroid gland: 59.1 nTPM (protected, limit 3); adipose tissue: 59.1 nTPM (manageable, limit 5); duodenum: 56.8 nTPM (vital, limit 1); lung: 56.6 nTPM (vital, limit 1); kidney: 55.8 nTPM (vital, limit 1); hypothalamus: 55.3 nTPM (vital, limit 1); adrenal gland: 54.4 nTPM (vital, limit 1); stomach: 54.3 nTPM (protected, limit 3); salivary gland: 54 nTPM (protected, limit 3); basal ganglia: 53.6 nTPM (vital, limit 1); cerebellum: 53.1 nTPM (vital, limit 1); hippocampal formation: 51 nTPM (vital, limit 1); bone marrow: 50.6 nTPM (vital, limit 1); spleen: 50.5 nTPM (manageable, limit 5); small intestine: 50.4 nTPM (vital, limit 1); midbrain: 50.3 nTPM (vital, limit 1); thyroid gland: 48.4 nTPM (manageable, limit 5); retina: 45.7 nTPM (vital, limit 1); spinal cord: 35.9 nTPM (vital, limit 1); pituitary gland: 33.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,UBE2V1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000247077,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 60.5263% (minimum 65%, Missing); adrenal gland: 48.4940% (minimum 75%, Missing); amygdala: 58.1227% (minimum 75%, Missing); basal ganglia: 58.5455% (minimum 75%, Missing); bone marrow: 49.2355% (minimum 75%, Missing); cerebellum: 52.7869% (minimum 75%, Missing); cerebral cortex: 47.6331% (minimum 75%, Missing); choroid plexus: 64.9194% (minimum 75%, Missing); colon: 50.1558% (minimum 70%, Missing); duodenum: 52.1036% (minimum 75%, Missing); esophagus: 41.0714% (minimum 70%, Missing); heart muscle: 45.3521% (minimum 75%, Missing); hippocampal formation: 52.7869% (minimum 75%, Missing); hypothalamus: 57.5000% (minimum 75%, Missing); kidney: 53.8462% (minimum 75%, Missing); liver: 36.3431% (minimum 75%, Missing); lung: 64.1434% (minimum 75%, Missing); lymph node: 43.5135% (minimum 70%, Missing); midbrain: 62.4031% (minimum 75%, Missing); pancreas: 39.0777% (minimum 75%, Missing); pituitary gland: 62.6459% (minimum 75%, Missing); rectum: 58.9744% (minimum 70%, Missing); retina: 73.5160% (minimum 75%, Missing); salivary gland: 51.1111% (minimum 70%, Missing); skeletal muscle: 33.4719% (minimum 60%, Enhanced); skin: 47.9167% (minimum 65%, Missing); small intestine: 55.7093% (minimum 75%, Missing); smooth muscle: 60.2996% (minimum 75%, Missing); spinal cord: 67.6471% (minimum 75%, Missing); spleen: 55.7093% (minimum 65%, Missing); stomach: 54.7619% (minimum 70%, Missing); thymus: 53.3113% (minimum 65%, Missing); thyroid gland: 58.9744% (minimum 65%, Missing); tongue: 47.0760% (minimum 70%, Missing); urinary bladder: 51.7685% (minimum 70%, Missing)",-0.170833,-0.289286,-0.386569,0,4,partial,32,23.1,17.5,"skeletal muscle: 32 nTPM (vital, limit 6); liver: 28.2 nTPM (vital, limit 1); pancreas: 25.1 nTPM (vital, limit 1); esophagus: 23.1 nTPM (protected, limit 3); lymph node: 20.9 nTPM (protected, limit 3); heart muscle: 19.4 nTPM (vital, limit 1); tongue: 18.1 nTPM (protected, limit 3); cerebral cortex: 17.7 nTPM (vital, limit 1); skin: 17.5 nTPM (manageable, limit 5); adrenal gland: 17.1 nTPM (vital, limit 1); bone marrow: 16.6 nTPM (vital, limit 1); colon: 16 nTPM (protected, limit 3); salivary gland: 15.4 nTPM (protected, limit 3); urinary bladder: 15 nTPM (protected, limit 3); duodenum: 14.8 nTPM (vital, limit 1); cerebellum: 14.4 nTPM (vital, limit 1); hippocampal formation: 14.4 nTPM (vital, limit 1); thymus: 14.1 nTPM (manageable, limit 5); kidney: 13.8 nTPM (vital, limit 1); stomach: 13.3 nTPM (protected, limit 3); small intestine: 12.8 nTPM (vital, limit 1); spleen: 12.8 nTPM (manageable, limit 5); hypothalamus: 11.9 nTPM (vital, limit 1); amygdala: 11.6 nTPM (vital, limit 1); basal ganglia: 11.4 nTPM (vital, limit 1); rectum: 11.2 nTPM (protected, limit 3); thyroid gland: 11.2 nTPM (manageable, limit 5); smooth muscle: 10.6 nTPM (vital, limit 1); adipose tissue: 10.5 nTPM (manageable, limit 5); midbrain: 9.7 nTPM (vital, limit 1); pituitary gland: 9.6 nTPM (vital, limit 1); lung: 9 nTPM (vital, limit 1); choroid plexus: 8.7 nTPM (vital, limit 1); spinal cord: 7.7 nTPM (vital, limit 1); retina: 5.8 nTPM (vital, limit 1)",adipose tissue / adipocytes: Low (Enhanced); adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Medium (Enhanced); bronchus / respiratory epithelial cells: Medium (Enhanced); caudate / glial cells: Medium (Enhanced); caudate / neuronal cells: Medium (Enhanced); cerebellum / cells in granular layer: Medium (Enhanced); cerebellum / cells in molecular layer: Low (Enhanced); cerebral cortex / endothelial cells: Medium (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: Medium (Enhanced); cerebral cortex / neuropil: Low (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: Medium (Enhanced); colon / peripheral nerve/ganglion: Medium (Enhanced); duodenum / glandular cells: Medium (Enhanced); esophagus / squamous epithelial cells: High (Enhanced); heart muscle / cardiomyocytes: Low (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: Medium (Enhanced); kidney / cells in glomeruli: Low (Enhanced); kidney / cells in tubules: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Medium (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Low (Enhanced); rectum / glandular cells: Medium (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skin 1 / fibroblasts: Medium (Enhanced); skin 1 / keratinocytes: Medium (Enhanced); skin 1 / Langerhans: Medium (Enhanced); skin 2 / epidermal cells: Medium (Enhanced); small intestine / glandular cells: Medium (Enhanced); smooth muscle / smooth muscle cells: Low (Enhanced); soft tissue 1 / chondrocytes: Medium (Enhanced); soft tissue 1 / fibroblasts: Low (Enhanced); soft tissue 1 / peripheral nerve: Low (Enhanced); soft tissue 2 / fibroblasts: Medium (Enhanced); soft tissue 2 / peripheral nerve: Low (Enhanced); spleen / cells in red pulp: Medium (Enhanced); spleen / cells in white pulp: High (Enhanced); stomach 1 / glandular cells: Low (Enhanced); stomach 2 / glandular cells: Medium (Enhanced); thyroid gland / glandular cells: Medium (Enhanced); urinary bladder / urothelial cells: Medium (Enhanced),56,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PGAM5,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000247746,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,,0.254494,0.199441,0.182432,0,6,partial,3.5,5.4,5.1,"parathyroid gland: 5.4 nTPM (protected, limit 3); thyroid gland: 5.1 nTPM (manageable, limit 5); kidney: 3.5 nTPM (vital, limit 1); retina: 3 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); hypothalamus: 2.4 nTPM (vital, limit 1); choroid plexus: 2.1 nTPM (vital, limit 1); heart muscle: 2 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); cerebellum: 1.6 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1); liver: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Medium (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Low (Uncertain); cerebellum / cells in granular layer: Medium (Uncertain); cerebellum / cells in molecular layer: High (Uncertain); cerebellum / Purkinje cells: High (Uncertain); cerebral cortex / endothelial cells: Medium (Uncertain); cerebral cortex / neuronal cells: High (Uncertain); colon / endothelial cells: High (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); esophagus / squamous epithelial cells: High (Uncertain); heart muscle / cardiomyocytes: Medium (Uncertain); hippocampus / neuronal cells: High (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); lung / alveolar cells: High (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: High (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: High (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Medium (Uncertain); parathyroid gland / glandular cells: High (Uncertain); rectum / glandular cells: High (Uncertain); salivary gland / glandular cells: High (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: High (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: High (Uncertain); small intestine / glandular cells: High (Uncertain); soft tissue 1 / fibroblasts: Low (Uncertain); soft tissue 1 / peripheral nerve: Low (Uncertain); soft tissue 2 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: High (Uncertain); stomach 1 / glandular cells: High (Uncertain); stomach 2 / glandular cells: High (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: High (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,USP51,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000248098,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 48.6614% (minimum 65%, Missing); adrenal gland: 28.9326% (minimum 75%, Missing); amygdala: 59.0822% (minimum 75%, Missing); basal ganglia: 57.0111% (minimum 75%, Missing); bone marrow: 49.1256% (minimum 75%, Missing); cerebellum: 61.5538% (minimum 75%, Missing); cerebral cortex: 55.0802% (minimum 75%, Missing); choroid plexus: 36.2251% (minimum 75%, Missing); colon: 60.3516% (minimum 70%, Missing); duodenum: 61.4314% (minimum 75%, Missing); esophagus: 32.8374% (minimum 70%, Missing); heart muscle: 26.0980% (minimum 75%, Missing); hippocampal formation: 62.8049% (minimum 75%, Missing); hypothalamus: 63.5802% (minimum 75%, Missing); kidney: 41.8133% (minimum 75%, Missing); liver: 22.3589% (minimum 75%, Missing); lung: 58.7452% (minimum 75%, Missing); lymph node: 56.3869% (minimum 70%, Missing); midbrain: 56.4899% (minimum 75%, Missing); pancreas: 40.8190% (minimum 75%, Missing); parathyroid gland: 36.2251% (minimum 70%, Missing); pituitary gland: 56.9061% (minimum 75%, Missing); rectum: 68.0617% (minimum 70%, Missing); retina: 59.5376% (minimum 75%, Missing); salivary gland: 43.7677% (minimum 70%, Missing); skeletal muscle: 22.5547% (minimum 75%, Missing); skin: 50.0000% (minimum 65%, Missing); small intestine: 62.9328% (minimum 75%, Missing); smooth muscle: 71.6937% (minimum 75%, Missing); spinal cord: 62.1730% (minimum 75%, Missing); spleen: 56.5934% (minimum 65%, Missing); stomach: 37.6829% (minimum 70%, Missing); thymus: 54.1156% (minimum 65%, Missing); thyroid gland: 43.3380% (minimum 65%, Missing); tongue: 20.8643% (minimum 70%, Missing); urinary bladder: 59.5376% (minimum 70%, Missing)",-0.21662,-0.491357,-0.526411,0,3,partial,107.3,117.2,40.4,"tongue: 117.2 nTPM (protected, limit 3); liver: 107.3 nTPM (vital, limit 1); skeletal muscle: 106.1 nTPM (vital, limit 1); heart muscle: 87.5 nTPM (vital, limit 1); adrenal gland: 75.9 nTPM (vital, limit 1); esophagus: 63.2 nTPM (protected, limit 3); parathyroid gland: 54.4 nTPM (protected, limit 3); choroid plexus: 54.4 nTPM (vital, limit 1); stomach: 51.1 nTPM (protected, limit 3); pancreas: 44.8 nTPM (vital, limit 1); kidney: 43 nTPM (vital, limit 1); thyroid gland: 40.4 nTPM (manageable, limit 5); salivary gland: 39.7 nTPM (protected, limit 3); adipose tissue: 32.6 nTPM (manageable, limit 5); bone marrow: 32 nTPM (vital, limit 1); skin: 30.9 nTPM (manageable, limit 5); thymus: 26.2 nTPM (manageable, limit 5); cerebral cortex: 25.2 nTPM (vital, limit 1); lymph node: 23.9 nTPM (protected, limit 3); midbrain: 23.8 nTPM (vital, limit 1); spleen: 23.7 nTPM (manageable, limit 5); pituitary gland: 23.4 nTPM (vital, limit 1); basal ganglia: 23.3 nTPM (vital, limit 1); lung: 21.7 nTPM (vital, limit 1); amygdala: 21.4 nTPM (vital, limit 1); retina: 21 nTPM (vital, limit 1); urinary bladder: 21 nTPM (protected, limit 3); colon: 20.3 nTPM (protected, limit 3); duodenum: 19.4 nTPM (vital, limit 1); cerebellum: 19.3 nTPM (vital, limit 1); spinal cord: 18.8 nTPM (vital, limit 1); hippocampal formation: 18.3 nTPM (vital, limit 1); small intestine: 18.2 nTPM (vital, limit 1); hypothalamus: 17.7 nTPM (vital, limit 1); rectum: 14.5 nTPM (protected, limit 3); smooth muscle: 12.2 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: Medium (Supported); caudate / neuronal cells: Medium (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: Low (Supported); cerebellum / Purkinje cells: High (Supported); cerebral cortex / endothelial cells: High (Supported); cerebral cortex / glial cells: Low (Supported); cerebral cortex / neuronal cells: Medium (Supported); cerebral cortex / neuropil: High (Supported); colon / endothelial cells: High (Supported); colon / glandular cells: High (Supported); colon / peripheral nerve/ganglion: Medium (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: Medium (Supported); hippocampus / neuronal cells: Medium (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: Medium (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: High (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: High (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: Medium (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: Medium (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BCKDHA,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000248099,True,compatible,,True,True,True,,0.348994,0.298994,0.24824,0,2,partial,1.8,2.8,5.1,,,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,INSL3,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,False,unchanged,
ENSG00000248383,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 63.6364% (minimum 65%, Missing); adrenal gland: 63.6364% (minimum 75%, Missing); amygdala: 63.6364% (minimum 75%, Missing); basal ganglia: 70.0000% (minimum 75%, Missing); cerebellum: 53.8462% (minimum 75%, Missing); cerebral cortex: 41.1765% (minimum 75%, Missing); hippocampal formation: 63.6364% (minimum 75%, Missing); hypothalamus: 58.3333% (minimum 75%, Missing); lung: 53.8462% (minimum 75%, Missing); lymph node: 36.8421% (minimum 70%, Missing); midbrain: 63.6364% (minimum 75%, Missing); pancreas: 38.8889% (minimum 75%, Missing); parathyroid gland: 2.3729% (minimum 70%, Missing); pituitary gland: 50.0000% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 63.6364% (minimum 70%, Missing); thyroid gland: 43.7500% (minimum 65%, Missing)",-0.2125,-0.676271,-0.361111,0,80,unavailable,1.1,28.8,0.9,"parathyroid gland: 28.8 nTPM (protected, limit 3); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHAC1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.18632/oncotarget.21715,Bruggeman 2018;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000248483,False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted,True,True,True,"retina: 65.5172% (minimum 75%, Missing)",0.3,0.25,-0.0948276,0,4,partial,1,0.2,0.4,,kidney / cells in tubules: Low (Enhanced),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,POU5F2,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000248767,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,FOXL3,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000248905,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"colon: 64.2857% (minimum 70%, Missing); pituitary gland: 73.3333% (minimum 75%, Missing); retina: 25.3846% (minimum 75%, Missing); stomach: 56.2500% (minimum 70%, Missing)",0.0622302,-0.1375,-0.496154,0,13,partial,29.1,7.7,4,"retina: 29.1 nTPM (vital, limit 1); stomach: 7.7 nTPM (protected, limit 3); colon: 5.5 nTPM (protected, limit 3); rectum: 4.2 nTPM (protected, limit 3); salivary gland: 4.1 nTPM (protected, limit 3); pituitary gland: 3.6 nTPM (vital, limit 1); lung: 3.3 nTPM (vital, limit 1); kidney: 2.7 nTPM (vital, limit 1); choroid plexus: 2.6 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); duodenum: 1.3 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Supported); bronchus / ciliated cells (cell body): Medium (Supported); colon / endothelial cells: Medium (Supported); colon / glandular cells: Medium (Supported); duodenum / glandular cells: Medium (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); kidney / bowman's capsule: Medium (Supported); kidney / cells in glomeruli: Low (Supported); kidney / collecting ducts: High (Supported); kidney / distal tubules: High (Supported); kidney / proximal tubules (cell body): Low (Supported); lung / macrophages: Low (Supported); nasopharynx / basal cells: Low (Supported); oral mucosa / squamous epithelial cells: Medium (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: Medium (Supported); retina / outer plexiform layer: High (Supported); retina / photoreceptor cells: High (Supported); salivary gland / glandular cells: Low (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / cells in basal layer: Low (Supported); skin 1 / cells in granular layer: Low (Supported); skin 1 / cells in spinous layer: Low (Supported); skin 1 / endothelial cells: Low (Supported); skin 1 / langerhans cells: Low (Supported); skin 2 / cells in basal layer: Low (Supported); skin 2 / cells in corneal layer: Low (Supported); skin 2 / cells in granular layer: Low (Supported); skin 2 / cells in spinous layer: Low (Supported); skin 2 / endothelial cells: High (Supported); skin 2 / fibrohistiocytic cells: Medium (Supported); skin 2 / langerhans cells: Low (Supported); skin 2 / lymphocytes: Low (Supported); small intestine / glandular cells: Medium (Supported); smooth muscle / smooth muscle cells: Medium (Supported); stomach 1 / glandular cells: Medium (Supported); stomach 2 / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),92,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / hair follicles; skin 1 / langerhans cells; skin 1 / melanocytes; skin 2 / cells in basal layer; skin 2 / cells in corneal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / fibrohistiocytic cells; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; spleen; thymus; tonsil; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FMN1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000249139,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,1,partial,0.1,0,0.1,,,54,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,EPPIN-WFDC6,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000249471,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 58.9286% (minimum 65%, Missing); adrenal gland: 61.1111% (minimum 75%, Missing); amygdala: 66.0000% (minimum 75%, Missing); basal ganglia: 62.2642% (minimum 75%, Missing); bone marrow: 66.0000% (minimum 75%, Missing); cerebellum: 55.0000% (minimum 75%, Missing); cerebral cortex: 52.3810% (minimum 75%, Missing); choroid plexus: 68.7500% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); duodenum: 64.7059% (minimum 75%, Missing); esophagus: 53.2258% (minimum 70%, Missing); heart muscle: 66.0000% (minimum 75%, Missing); hippocampal formation: 64.7059% (minimum 75%, Missing); hypothalamus: 66.0000% (minimum 75%, Missing); kidney: 60.0000% (minimum 75%, Missing); liver: 57.8947% (minimum 75%, Missing); lung: 60.0000% (minimum 75%, Missing); lymph node: 60.0000% (minimum 70%, Missing); midbrain: 71.7391% (minimum 75%, Missing); pancreas: 48.5294% (minimum 75%, Missing); parathyroid gland: 56.8966% (minimum 70%, Missing); pituitary gland: 52.3810% (minimum 75%, Missing); rectum: 66.0000% (minimum 70%, Missing); retina: 64.7059% (minimum 75%, Missing); salivary gland: 55.9322% (minimum 70%, Missing); skeletal muscle: 52.3810% (minimum 75%, Missing); skin: 47.1429% (minimum 65%, Missing); small intestine: 60.0000% (minimum 75%, Missing); smooth muscle: 61.1111% (minimum 75%, Missing); spinal cord: 73.3333% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 55.9322% (minimum 70%, Missing); thymus: 56.8966% (minimum 65%, Missing); thyroid gland: 55.0000% (minimum 65%, Missing); tongue: 67.3469% (minimum 70%, Missing); urinary bladder: 53.2258% (minimum 70%, Missing)",-0.178571,-0.167742,-0.264706,0,80,unavailable,3.5,2.9,3.7,"pancreas: 3.5 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); skeletal muscle: 3 nTPM (vital, limit 1); pituitary gland: 3 nTPM (vital, limit 1); cerebellum: 2.7 nTPM (vital, limit 1); liver: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); small intestine: 2.2 nTPM (vital, limit 1); lung: 2.2 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); adrenal gland: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); duodenum: 1.8 nTPM (vital, limit 1); retina: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); bone marrow: 1.7 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF324B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000249481,True,compatible,,True,True,True,,0.345349,0.3,0.205357,0,4,partial,1,0.1,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;lymphatic_and_immune_function_review;thymic_function_review,lymph node; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATS1,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000249581,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"kidney: 50.0000% (minimum 75%, Missing); salivary gland: 50.0000% (minimum 70%, Missing)",0.35,-0.2,-0.25,0,80,unavailable,0.1,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,CLRN2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000249693,True,compatible,,True,True,True,,0.268919,0.244444,0.121795,0,80,unavailable,0.5,0.2,0.3,,,0,not_established,required,in_situ_inflammation_review;local_control_not_guaranteed;skin_compartment_and_extent_review,gallbladder; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPMAP2L,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1136/jitc-2023-007935,Carter 2023;Chang 2019 · TGCT,False,True,True,True,True,gained,selectivity_revised
ENSG00000249709,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 61.5385% (minimum 65%, Missing); adrenal gland: 67.9245% (minimum 75%, Missing); basal ganglia: 72.0000% (minimum 75%, Missing); bone marrow: 62.6087% (minimum 75%, Missing); cerebral cortex: 72.0000% (minimum 75%, Missing); choroid plexus: 64.2857% (minimum 75%, Missing); colon: 50.0000% (minimum 70%, Missing); duodenum: 54.1353% (minimum 75%, Missing); heart muscle: 59.5041% (minimum 75%, Missing); kidney: 49.3151% (minimum 75%, Missing); liver: 56.6929% (minimum 75%, Missing); lung: 63.7168% (minimum 75%, Missing); lymph node: 51.7986% (minimum 70%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 49.6552% (minimum 70%, Missing); pituitary gland: 69.9029% (minimum 75%, Missing); rectum: 50.7042% (minimum 70%, Missing); retina: 51.0638% (minimum 75%, Missing); salivary gland: 60.5042% (minimum 70%, Missing); skeletal muscle: 54.5455% (minimum 75%, Missing); skin: 58.0645% (minimum 65%, Missing); small intestine: 51.0638% (minimum 75%, Missing); smooth muscle: 63.1579% (minimum 75%, Missing); spleen: 51.7986% (minimum 65%, Missing); stomach: 52.1739% (minimum 70%, Missing); thymus: 49.6552% (minimum 65%, Missing); thyroid gland: 48.3221% (minimum 65%, Missing); tongue: 48.3221% (minimum 70%, Missing); urinary bladder: 58.5366% (minimum 70%, Missing)",-0.166779,-0.216779,-0.256849,0,80,unavailable,7.4,7.7,7.7,"tongue: 7.7 nTPM (protected, limit 3); thyroid gland: 7.7 nTPM (manageable, limit 5); kidney: 7.4 nTPM (vital, limit 1); thymus: 7.3 nTPM (manageable, limit 5); parathyroid gland: 7.3 nTPM (protected, limit 3); colon: 7.2 nTPM (protected, limit 3); rectum: 7 nTPM (protected, limit 3); small intestine: 6.9 nTPM (vital, limit 1); retina: 6.9 nTPM (vital, limit 1); spleen: 6.7 nTPM (manageable, limit 5); lymph node: 6.7 nTPM (protected, limit 3); stomach: 6.6 nTPM (protected, limit 3); duodenum: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); liver: 5.5 nTPM (vital, limit 1); skin: 5.2 nTPM (manageable, limit 5); urinary bladder: 5.1 nTPM (protected, limit 3); heart muscle: 4.9 nTPM (vital, limit 1); salivary gland: 4.7 nTPM (protected, limit 3); bone marrow: 4.3 nTPM (vital, limit 1); smooth muscle: 4.2 nTPM (vital, limit 1); lung: 4.1 nTPM (vital, limit 1); choroid plexus: 4 nTPM (vital, limit 1); pancreas: 3.6 nTPM (vital, limit 1); adrenal gland: 3.4 nTPM (vital, limit 1); pituitary gland: 3.1 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); basal ganglia: 2.8 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); amygdala: 2.3 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); midbrain: 2 nTPM (vital, limit 1); hypothalamus: 1.9 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF564,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000249861,True,compatible,,True,True,True,,0.35,0.3,0.183333,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LGALS16,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,True,True,True,True,gained,selectivity_revised
ENSG00000249884,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"amygdala: 57.1429% (minimum 75%, Missing); basal ganglia: 48.0000% (minimum 75%, Missing); bone marrow: 22.6415% (minimum 75%, Missing); cerebellum: 70.5882% (minimum 75%, Missing); cerebral cortex: 33.3333% (minimum 75%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 63.1579% (minimum 70%, Missing); heart muscle: 23.0769% (minimum 75%, Missing); hippocampal formation: 60.0000% (minimum 75%, Missing); hypothalamus: 63.1579% (minimum 75%, Missing); midbrain: 70.5882% (minimum 75%, Missing); retina: 75.0000% (minimum 75%, Missing); skeletal muscle: 36.3636% (minimum 75%, Missing); stomach: 57.1429% (minimum 70%, Missing)",0.0166667,-0.128571,-0.523585,0,80,unavailable,4.1,0.9,0.6,"bone marrow: 4.1 nTPM (vital, limit 1); heart muscle: 4 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); skeletal muscle: 2.1 nTPM (vital, limit 1); basal ganglia: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,RNF103-CHMP3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000249961,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.303125,0.276,0.147059,0,80,unavailable,1.4,0.3,0.6,"bone marrow: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TERB1,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000250120,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 57.5758% (minimum 75%, Missing); basal ganglia: 55.8824% (minimum 75%, Missing); cerebellum: 39.5833% (minimum 75%, Missing); cerebral cortex: 19.1919% (minimum 75%, Missing); hippocampal formation: 57.5758% (minimum 75%, Missing); hypothalamus: 65.5172% (minimum 75%, Missing); kidney: 57.5758% (minimum 75%, Missing); lung: 73.0769% (minimum 75%, Missing); midbrain: 59.3750% (minimum 75%, Missing); pancreas: 32.2034% (minimum 75%, Missing); pituitary gland: 57.5758% (minimum 75%, Missing); retina: 45.2381% (minimum 75%, Missing); small intestine: 73.0769% (minimum 75%, Missing); smooth muscle: 55.8824% (minimum 75%, Missing); spinal cord: 42.2222% (minimum 75%, Missing); thyroid gland: 48.7179% (minimum 65%, Missing)",-0.162821,0.0307692,-0.558081,0,80,unavailable,8,0.7,2,"cerebral cortex: 8 nTPM (vital, limit 1); pancreas: 4 nTPM (vital, limit 1); cerebellum: 2.9 nTPM (vital, limit 1); spinal cord: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1); amygdala: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); kidney: 1.4 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHA10,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000250312,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.0000% (minimum 65%, Missing); adrenal gland: 52.4590% (minimum 75%, Missing); amygdala: 71.1111% (minimum 75%, Missing); basal ganglia: 69.5652% (minimum 75%, Missing); bone marrow: 52.4590% (minimum 75%, Missing); cerebellum: 60.3774% (minimum 75%, Missing); cerebral cortex: 53.3333% (minimum 75%, Missing); choroid plexus: 72.7273% (minimum 75%, Missing); colon: 57.1429% (minimum 70%, Missing); duodenum: 66.6667% (minimum 75%, Missing); esophagus: 65.3061% (minimum 70%, Missing); heart muscle: 62.7451% (minimum 75%, Missing); hippocampal formation: 71.1111% (minimum 75%, Missing); hypothalamus: 68.0851% (minimum 75%, Missing); kidney: 57.1429% (minimum 75%, Missing); liver: 69.5652% (minimum 75%, Missing); lung: 62.7451% (minimum 75%, Missing); lymph node: 46.3768% (minimum 70%, Missing); midbrain: 68.0851% (minimum 75%, Missing); pancreas: 56.1404% (minimum 75%, Missing); parathyroid gland: 55.1724% (minimum 70%, Missing); pituitary gland: 62.7451% (minimum 75%, Missing); rectum: 60.3774% (minimum 70%, Missing); retina: 55.1724% (minimum 75%, Missing); salivary gland: 60.3774% (minimum 70%, Missing); skin: 52.4590% (minimum 65%, Missing); small intestine: 64.0000% (minimum 75%, Missing); smooth muscle: 64.0000% (minimum 75%, Missing); spinal cord: 64.0000% (minimum 75%, Missing); spleen: 53.3333% (minimum 65%, Missing); stomach: 64.0000% (minimum 70%, Missing); thymus: 41.5584% (minimum 65%, Missing); thyroid gland: 41.0256% (minimum 65%, Missing); tongue: 65.3061% (minimum 70%, Missing); urinary bladder: 62.7451% (minimum 70%, Missing)",-0.239744,-0.236232,-0.22541,0,80,unavailable,2.9,3.7,4.6,"lymph node: 3.7 nTPM (protected, limit 3); adrenal gland: 2.9 nTPM (vital, limit 1); bone marrow: 2.9 nTPM (vital, limit 1); cerebral cortex: 2.8 nTPM (vital, limit 1); retina: 2.6 nTPM (vital, limit 1); pancreas: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 1); cerebellum: 2.1 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); lung: 1.9 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); small intestine: 1.8 nTPM (vital, limit 1); smooth muscle: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); hypothalamus: 1.5 nTPM (vital, limit 1); midbrain: 1.5 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); hippocampal formation: 1.3 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); choroid plexus: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF718,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000250423,True,compatible,,True,True,True,,0.35,0.3,0.247555,0,3,partial,1.3,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KIAA1210,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y,Bruggeman 2018;Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016,True,True,True,True,False,unchanged,
ENSG00000250565,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.308333,0.245205,0.117925,0,8,partial,4.2,2.3,2.8,"basal ganglia: 4.2 nTPM (vital, limit 1); spinal cord: 3.8 nTPM (vital, limit 1); midbrain: 3.6 nTPM (vital, limit 1); amygdala: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.3 nTPM (vital, limit 1); pituitary gland: 2.7 nTPM (vital, limit 1); hypothalamus: 2.6 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); choroid plexus: 2 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",,71,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ATP6V1E2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000250709,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.34,0.270588,0.211165,0,80,unavailable,0.4,0.3,0.1,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,CCDC169-SOHLH2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000250719,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,P3R3URF,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000250741,True,compatible,,True,True,True,,0.35,0.3,0.243827,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NT5C1B-RDH14,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000250803,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.348984,0.3,0.24797,0,80,unavailable,0.2,0,0.1,,,0,not_established,required,in_situ_inflammation_review,gallbladder,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ZNF475,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000251258,True,compatible,,True,True,True,,0.35,0.3,0.0921053,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RFPL4B,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000251493,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 64.0000% (minimum 75%, Missing); amygdala: 74.4186% (minimum 75%, Missing); basal ganglia: 64.0000% (minimum 75%, Missing); cerebral cortex: 71.1111% (minimum 75%, Missing); choroid plexus: 68.0851% (minimum 75%, Missing); esophagus: 65.3061% (minimum 70%, Missing); hippocampal formation: 74.4186% (minimum 75%, Missing); hypothalamus: 54.2373% (minimum 75%, Missing); kidney: 60.3774% (minimum 75%, Missing); midbrain: 64.0000% (minimum 75%, Missing); pituitary gland: 62.7451% (minimum 75%, Missing); small intestine: 72.7273% (minimum 75%, Missing); tongue: 62.7451% (minimum 70%, Missing)",0.0772727,-0.072549,-0.207627,0,80,unavailable,2.7,1.9,1.2,"hypothalamus: 2.7 nTPM (vital, limit 1); kidney: 2.1 nTPM (vital, limit 1); pituitary gland: 1.9 nTPM (vital, limit 1); adrenal gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); choroid plexus: 1.5 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); small intestine: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FOXD1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000251503,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.296237,0.261749,0.0591954,0,80,unavailable,8.3,1.4,2,"bone marrow: 8.3 nTPM (vital, limit 1); basal ganglia: 4.5 nTPM (vital, limit 1); amygdala: 4 nTPM (vital, limit 1); cerebral cortex: 3.8 nTPM (vital, limit 1); hypothalamus: 3.5 nTPM (vital, limit 1); hippocampal formation: 3.2 nTPM (vital, limit 1); midbrain: 2.9 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); retina: 2.4 nTPM (vital, limit 1); kidney: 2.2 nTPM (vital, limit 1); spinal cord: 1.9 nTPM (vital, limit 1); duodenum: 1.6 nTPM (vital, limit 1); liver: 1.2 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,CENPS-CORT,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000253506,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.329592,0.282677,0.232677,0,80,unavailable,1.1,1.1,1.3,"pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NACA2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000253910,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 48.2759% (minimum 75%, Missing); basal ganglia: 48.2759% (minimum 75%, Missing); cerebellum: 46.6667% (minimum 75%, Missing); cerebral cortex: 43.7500% (minimum 75%, Missing); heart muscle: 62.2222% (minimum 75%, Missing); hippocampal formation: 57.1429% (minimum 75%, Missing); hypothalamus: 62.2222% (minimum 75%, Missing); lung: 63.6364% (minimum 75%, Missing); midbrain: 63.6364% (minimum 75%, Missing); retina: 65.1163% (minimum 75%, Missing); smooth muscle: 66.6667% (minimum 75%, Missing); spinal cord: 65.1163% (minimum 75%, Missing)",0.0166667,0.0179487,-0.3125,0,80,unavailable,3.6,1.1,1.4,"cerebral cortex: 3.6 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); amygdala: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.1 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1); hypothalamus: 1.7 nTPM (vital, limit 1); lung: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); spinal cord: 1.5 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHGB2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000254221,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 61.1111% (minimum 75%, Missing); amygdala: 36.6667% (minimum 75%, Missing); basal ganglia: 36.6667% (minimum 75%, Missing); cerebellum: 52.3810% (minimum 75%, Missing); cerebral cortex: 8.1481% (minimum 75%, Missing); heart muscle: 68.7500% (minimum 75%, Missing); hippocampal formation: 44.0000% (minimum 75%, Missing); hypothalamus: 50.0000% (minimum 75%, Missing); kidney: 73.3333% (minimum 75%, Missing); lung: 64.7059% (minimum 75%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 61.1111% (minimum 75%, Missing); parathyroid gland: 34.3750% (minimum 70%, Missing); pituitary gland: 52.3810% (minimum 75%, Missing); retina: 42.3077% (minimum 75%, Missing); smooth muscle: 57.8947% (minimum 75%, Missing); spinal cord: 47.8261% (minimum 75%, Missing); thyroid gland: 64.7059% (minimum 65%, Missing)",-0.00294118,-0.35625,-0.668519,0,80,unavailable,12.4,2.1,0.6,"cerebral cortex: 12.4 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); basal ganglia: 1.9 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); hippocampal formation: 1.4 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHGB1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000254535,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"parathyroid gland: 65.5629% (minimum 70%, Missing)",0.181933,-0.0443709,0.0614754,0,80,unavailable,2.3,5.2,2,"parathyroid gland: 5.2 nTPM (protected, limit 3); smooth muscle: 2.3 nTPM (vital, limit 1); heart muscle: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PABPC4L,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000254726,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"cerebral cortex: 73.0769% (minimum 75%, Missing)",0.213636,0.138235,-0.0192308,0,80,unavailable,2.1,1.1,0.9,"cerebral cortex: 2.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MEX3A,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000255150,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.292857,0.208257,0.152736,0,2,partial,6.4,6,3.6,"retina: 6.4 nTPM (vital, limit 1); lymph node: 6 nTPM (protected, limit 3); bone marrow: 5.2 nTPM (vital, limit 1); pituitary gland: 3.6 nTPM (vital, limit 1); adrenal gland: 3 nTPM (vital, limit 1); lung: 2.9 nTPM (vital, limit 1); cerebellum: 2.8 nTPM (vital, limit 1); small intestine: 2.6 nTPM (vital, limit 1); hypothalamus: 2.5 nTPM (vital, limit 1); basal ganglia: 2.4 nTPM (vital, limit 1); pancreas: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); cerebral cortex: 2.2 nTPM (vital, limit 1); smooth muscle: 2.2 nTPM (vital, limit 1); heart muscle: 1.9 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); liver: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",cerebellum / Purkinje cells: Low (Uncertain); colon / glandular cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); kidney / cells in tubules: Low (Uncertain); rectum / glandular cells: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,EID3,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499,Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000255181,True,compatible,,True,True,True,,0.35,0.3,0.22561,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC166,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000255223,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"urinary bladder: 50.0000% (minimum 70%, Missing)",0.35,-0.2,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR5M11,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000255251,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.24945,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,PRR23D1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000255298,False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR8G5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000255346,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"smooth muscle: 55.5556% (minimum 75%, Missing); spleen: 10.6383% (minimum 65%, Missing)",-0.543617,0.209091,-0.194444,0,80,unavailable,0.8,0.1,8.4,"spleen: 8.4 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review,gallbladder; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NOX5,current_adaptive,True,False,False,False,10.1038/ncomms10499,Wang 2016,False,False,False,False,False,unchanged,
ENSG00000255359,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CCDC179,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000255378,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.178571,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,PRR23D2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000255408,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 65.0000% (minimum 75%, Missing); amygdala: 56.5217% (minimum 75%, Missing); basal ganglia: 54.1667% (minimum 75%, Missing); cerebellum: 39.3939% (minimum 75%, Missing); cerebral cortex: 50.0000% (minimum 75%, Missing); hippocampal formation: 54.1667% (minimum 75%, Missing); hypothalamus: 54.1667% (minimum 75%, Missing); kidney: 68.4211% (minimum 75%, Missing); lung: 61.9048% (minimum 75%, Missing); midbrain: 61.9048% (minimum 75%, Missing); pancreas: 54.1667% (minimum 75%, Missing); pituitary gland: 48.1481% (minimum 75%, Missing); retina: 59.0909% (minimum 75%, Missing); spinal cord: 50.0000% (minimum 75%, Missing)",0.0722222,0.0222222,-0.356061,0,80,unavailable,2,0.5,0.5,"cerebellum: 2 nTPM (vital, limit 1); pituitary gland: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); pancreas: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHA3,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000255529,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 64.2447% (minimum 65%, Missing); adrenal gland: 63.3962% (minimum 75%, Missing); amygdala: 62.4535% (minimum 75%, Missing); basal ganglia: 64.9903% (minimum 75%, Missing); bone marrow: 66.7992% (minimum 75%, Missing); cerebral cortex: 64.2447% (minimum 75%, Missing); colon: 69.1358% (minimum 70%, Missing); duodenum: 73.8462% (minimum 75%, Missing); esophagus: 69.4215% (minimum 70%, Missing); heart muscle: 54.4571% (minimum 75%, Missing); hippocampal formation: 63.2768% (minimum 75%, Missing); hypothalamus: 62.9213% (minimum 75%, Missing); kidney: 63.3962% (minimum 75%, Missing); liver: 69.2784% (minimum 75%, Missing); lung: 70.8861% (minimum 75%, Missing); lymph node: 64.2447% (minimum 70%, Missing); midbrain: 58.0311% (minimum 75%, Missing); pancreas: 68.2927% (minimum 75%, Missing); parathyroid gland: 57.6329% (minimum 70%, Missing); rectum: 69.7095% (minimum 70%, Missing); retina: 73.2026% (minimum 75%, Missing); salivary gland: 68.2927% (minimum 70%, Missing); skeletal muscle: 49.1947% (minimum 75%, Missing); small intestine: 72.4138% (minimum 75%, Missing); smooth muscle: 56.2814% (minimum 75%, Missing); spinal cord: 58.0311% (minimum 75%, Missing); spleen: 61.8785% (minimum 65%, Missing); stomach: 69.7095% (minimum 70%, Missing); thymus: 61.7647% (minimum 65%, Missing); thyroid gland: 58.9474% (minimum 65%, Missing); tongue: 47.3239% (minimum 70%, Missing); urinary bladder: 69.7095% (minimum 70%, Missing)",-0.0605263,-0.226761,-0.258053,0,80,unavailable,34.7,37.4,23.4,"tongue: 37.4 nTPM (protected, limit 3); skeletal muscle: 34.7 nTPM (vital, limit 1); heart muscle: 28.1 nTPM (vital, limit 1); smooth muscle: 26.1 nTPM (vital, limit 1); parathyroid gland: 24.7 nTPM (protected, limit 3); midbrain: 24.3 nTPM (vital, limit 1); spinal cord: 24.3 nTPM (vital, limit 1); thyroid gland: 23.4 nTPM (manageable, limit 5); thymus: 20.8 nTPM (manageable, limit 5); spleen: 20.7 nTPM (manageable, limit 5); amygdala: 20.2 nTPM (vital, limit 1); hypothalamus: 19.8 nTPM (vital, limit 1); hippocampal formation: 19.5 nTPM (vital, limit 1); kidney: 19.4 nTPM (vital, limit 1); adrenal gland: 19.4 nTPM (vital, limit 1); lymph node: 18.7 nTPM (protected, limit 3); adipose tissue: 18.7 nTPM (manageable, limit 5); cerebral cortex: 18.7 nTPM (vital, limit 1); basal ganglia: 18.1 nTPM (vital, limit 1); bone marrow: 16.7 nTPM (vital, limit 1); pancreas: 15.6 nTPM (vital, limit 1); salivary gland: 15.6 nTPM (protected, limit 3); colon: 15 nTPM (protected, limit 3); skin: 14.9 nTPM (manageable, limit 5); liver: 14.9 nTPM (vital, limit 1); esophagus: 14.8 nTPM (protected, limit 3); stomach: 14.6 nTPM (protected, limit 3); urinary bladder: 14.6 nTPM (protected, limit 3); rectum: 14.6 nTPM (protected, limit 3); lung: 13.8 nTPM (vital, limit 1); small intestine: 12.8 nTPM (vital, limit 1); retina: 12.3 nTPM (vital, limit 1); duodenum: 11.9 nTPM (vital, limit 1); cerebellum: 11.1 nTPM (vital, limit 1); choroid plexus: 9.5 nTPM (vital, limit 1); pituitary gland: 8.8 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,POLR2M,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000256061,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"choroid plexus: 40.2062% (minimum 75%, Missing); kidney: 70.0599% (minimum 75%, Missing); lung: 72.6708% (minimum 75%, Uncertain); parathyroid gland: 58.2090% (minimum 70%, Missing); retina: 28.9604% (minimum 75%, Missing); thyroid gland: 57.9208% (minimum 65%, Missing)",-0.0707921,-0.11791,-0.460396,0,3,partial,28.7,8.4,8.5,"retina: 28.7 nTPM (vital, limit 1); choroid plexus: 17.4 nTPM (vital, limit 1); thyroid gland: 8.5 nTPM (manageable, limit 5); parathyroid gland: 8.4 nTPM (protected, limit 3); kidney: 5 nTPM (vital, limit 1); lung: 4.4 nTPM (vital, limit 1); hypothalamus: 3.7 nTPM (vital, limit 1); pituitary gland: 3.5 nTPM (vital, limit 1); cerebral cortex: 3 nTPM (vital, limit 1); basal ganglia: 3 nTPM (vital, limit 1); hippocampal formation: 2.5 nTPM (vital, limit 1); amygdala: 2.4 nTPM (vital, limit 1); adrenal gland: 2.3 nTPM (vital, limit 1); smooth muscle: 2.1 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); bone marrow: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); heart muscle: 1.6 nTPM (vital, limit 1); spinal cord: 1.2 nTPM (vital, limit 1)",adrenal gland / glandular cells: Medium (Uncertain); bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: High (Uncertain); caudate / glial cells: Medium (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); colon / endothelial cells: Low (Uncertain); colon / glandular cells: Medium (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Medium (Uncertain); esophagus / squamous epithelial cells: Medium (Uncertain); heart muscle / cardiomyocytes: High (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in glomeruli: Low (Uncertain); kidney / cells in tubules: Medium (Uncertain); liver / hepatocytes: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: High (Uncertain); oral mucosa / squamous epithelial cells: Medium (Uncertain); pancreas / exocrine glandular cells: High (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Medium (Uncertain); salivary gland / glandular cells: Medium (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Low (Uncertain); skin 1 / keratinocytes: Medium (Uncertain); skin 1 / Langerhans: Medium (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Medium (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 2 / fibroblasts: Low (Uncertain); soft tissue 2 / peripheral nerve: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: High (Uncertain); urinary bladder / urothelial cells: Medium (Uncertain),51,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DNAAF4,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000256223,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 62.3978% (minimum 75%, Missing); bone marrow: 72.9299% (minimum 75%, Missing); choroid plexus: 66.1850% (minimum 75%, Missing); colon: 68.3582% (minimum 70%, Missing); heart muscle: 74.1100% (minimum 75%, Missing); kidney: 68.3582% (minimum 75%, Missing); liver: 68.7688% (minimum 75%, Missing); pancreas: 64.1457% (minimum 75%, Missing); parathyroid gland: 57.6826% (minimum 70%, Missing); pituitary gland: 34.1791% (minimum 75%, Missing); retina: 64.3258% (minimum 75%, Missing); smooth muscle: 73.3974% (minimum 75%, Missing); stomach: 69.1843% (minimum 70%, Missing); thyroid gland: 52.7650% (minimum 65%, Missing); urinary bladder: 68.7688% (minimum 70%, Missing)",-0.12235,-0.123174,-0.408209,0,80,unavailable,44.1,16.8,20.5,"pituitary gland: 44.1 nTPM (vital, limit 1); thyroid gland: 20.5 nTPM (manageable, limit 5); parathyroid gland: 16.8 nTPM (protected, limit 3); adrenal gland: 13.8 nTPM (vital, limit 1); pancreas: 12.8 nTPM (vital, limit 1); retina: 12.7 nTPM (vital, limit 1); choroid plexus: 11.7 nTPM (vital, limit 1); colon: 10.6 nTPM (protected, limit 3); kidney: 10.6 nTPM (vital, limit 1); liver: 10.4 nTPM (vital, limit 1); urinary bladder: 10.4 nTPM (protected, limit 3); stomach: 10.2 nTPM (protected, limit 3); skin: 8.6 nTPM (manageable, limit 5); bone marrow: 8.5 nTPM (vital, limit 1); smooth muscle: 8.3 nTPM (vital, limit 1); heart muscle: 8 nTPM (vital, limit 1); salivary gland: 7.7 nTPM (protected, limit 3); thymus: 7.5 nTPM (manageable, limit 5); lung: 7.4 nTPM (vital, limit 1); small intestine: 6.9 nTPM (vital, limit 1); cerebellum: 6.7 nTPM (vital, limit 1); adipose tissue: 6.5 nTPM (manageable, limit 5); hypothalamus: 6.1 nTPM (vital, limit 1); tongue: 6.1 nTPM (protected, limit 3); rectum: 6 nTPM (protected, limit 3); spleen: 5.9 nTPM (manageable, limit 5); lymph node: 5.8 nTPM (protected, limit 3); esophagus: 5.8 nTPM (protected, limit 3); cerebral cortex: 5.6 nTPM (vital, limit 1); basal ganglia: 4.9 nTPM (vital, limit 1); spinal cord: 4.8 nTPM (vital, limit 1); skeletal muscle: 4.7 nTPM (vital, limit 1); amygdala: 4.5 nTPM (vital, limit 1); hippocampal formation: 4.4 nTPM (vital, limit 1); midbrain: 4.2 nTPM (vital, limit 1); duodenum: 3.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF10,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000256294,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 64.9215% (minimum 75%, Missing)",0.0585714,0.042515,-0.100785,0,80,unavailable,6.7,4.3,5.1,"retina: 6.7 nTPM (vital, limit 1); thymus: 5.1 nTPM (manageable, limit 5); parathyroid gland: 4.3 nTPM (protected, limit 3); choroid plexus: 3.8 nTPM (vital, limit 1); lymph node: 3.6 nTPM (protected, limit 3); cerebral cortex: 3.3 nTPM (vital, limit 1); cerebellum: 3.2 nTPM (vital, limit 1); heart muscle: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 1); kidney: 2.9 nTPM (vital, limit 1); lung: 2.7 nTPM (vital, limit 1); liver: 2.7 nTPM (vital, limit 1); skeletal muscle: 2.5 nTPM (vital, limit 1); duodenum: 2.4 nTPM (vital, limit 1); pituitary gland: 2.4 nTPM (vital, limit 1); smooth muscle: 2.4 nTPM (vital, limit 1); bone marrow: 2.3 nTPM (vital, limit 1); small intestine: 2.1 nTPM (vital, limit 1); basal ganglia: 2 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); pancreas: 1.9 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); midbrain: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF225,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000256453,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.271875,0.267213,0.0472973,0,80,unavailable,3,0.4,1,"cerebellum: 3 nTPM (vital, limit 1); choroid plexus: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DND1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000256660,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"bone marrow: 70.6522% (minimum 75%, Missing)",0.101445,0.292366,-0.0434783,0,80,unavailable,5.4,0.1,4.3,"bone marrow: 5.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CLEC12B,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41388-018-0357-2,Bruggeman 2018;Chang 2019 · TGCT;Wang 2016,False,False,False,False,False,unchanged,
ENSG00000256980,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"basal ganglia: 40.0000% (minimum 75%, Missing)",0.281034,0.281818,-0.35,0,80,unavailable,8.1,0.1,0.4,"basal ganglia: 8.1 nTPM (vital, limit 1); cerebellum: 1.8 nTPM (vital, limit 1); pituitary gland: 1.5 nTPM (vital, limit 1); amygdala: 1.3 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;in_situ_inflammation_review;thymic_function_review,gallbladder; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,KHDC1L,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000257218,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 54.4601% (minimum 65%, Missing); adrenal gland: 53.7037% (minimum 75%, Missing); amygdala: 53.9535% (minimum 75%, Missing); basal ganglia: 56.0386% (minimum 75%, Missing); bone marrow: 61.3757% (minimum 75%, Missing); cerebellum: 43.6090% (minimum 75%, Missing); cerebral cortex: 50.6550% (minimum 75%, Missing); choroid plexus: 58.8832% (minimum 75%, Missing); colon: 54.2056% (minimum 70%, Missing); duodenum: 50.4348% (minimum 75%, Missing); esophagus: 57.7114% (minimum 70%, Missing); heart muscle: 64.4444% (minimum 75%, Missing); hippocampal formation: 51.3274% (minimum 75%, Missing); hypothalamus: 53.7037% (minimum 75%, Missing); kidney: 44.1065% (minimum 75%, Missing); liver: 42.3358% (minimum 75%, Missing); lung: 58.2915% (minimum 75%, Missing); lymph node: 53.9535% (minimum 70%, Missing); midbrain: 50.0000% (minimum 75%, Missing); pancreas: 24.0166% (minimum 75%, Missing); parathyroid gland: 47.9339% (minimum 70%, Missing); pituitary gland: 60.1036% (minimum 75%, Missing); rectum: 52.9680% (minimum 70%, Missing); retina: 48.3333% (minimum 75%, Missing); salivary gland: 53.4562% (minimum 70%, Missing); skeletal muscle: 58.5859% (minimum 75%, Missing); skin: 55.7692% (minimum 65%, Missing); small intestine: 53.9535% (minimum 75%, Missing); smooth muscle: 60.7330% (minimum 75%, Missing); spinal cord: 43.2836% (minimum 75%, Missing); spleen: 56.3107% (minimum 65%, Missing); stomach: 55.5024% (minimum 70%, Missing); thymus: 50.0000% (minimum 65%, Missing); thyroid gland: 50.8772% (minimum 65%, Missing); tongue: 60.1036% (minimum 70%, Missing); urinary bladder: 54.7170% (minimum 70%, Missing)",-0.15,-0.220661,-0.509834,0,80,unavailable,36.7,12.6,11.6,"pancreas: 36.7 nTPM (vital, limit 1); liver: 15.8 nTPM (vital, limit 1); spinal cord: 15.2 nTPM (vital, limit 1); cerebellum: 15 nTPM (vital, limit 1); kidney: 14.7 nTPM (vital, limit 1); parathyroid gland: 12.6 nTPM (protected, limit 3); retina: 12.4 nTPM (vital, limit 1); midbrain: 11.6 nTPM (vital, limit 1); thymus: 11.6 nTPM (manageable, limit 5); duodenum: 11.4 nTPM (vital, limit 1); cerebral cortex: 11.3 nTPM (vital, limit 1); thyroid gland: 11.2 nTPM (manageable, limit 5); hippocampal formation: 11 nTPM (vital, limit 1); rectum: 10.3 nTPM (protected, limit 3); salivary gland: 10.1 nTPM (protected, limit 3); hypothalamus: 10 nTPM (vital, limit 1); adrenal gland: 10 nTPM (vital, limit 1); lymph node: 9.9 nTPM (protected, limit 3); amygdala: 9.9 nTPM (vital, limit 1); small intestine: 9.9 nTPM (vital, limit 1); colon: 9.8 nTPM (protected, limit 3); adipose tissue: 9.7 nTPM (manageable, limit 5); urinary bladder: 9.6 nTPM (protected, limit 3); stomach: 9.3 nTPM (protected, limit 3); skin: 9.2 nTPM (manageable, limit 5); basal ganglia: 9.1 nTPM (vital, limit 1); spleen: 9 nTPM (manageable, limit 5); esophagus: 8.5 nTPM (protected, limit 3); lung: 8.3 nTPM (vital, limit 1); skeletal muscle: 8.2 nTPM (vital, limit 1); choroid plexus: 8.1 nTPM (vital, limit 1); pituitary gland: 7.7 nTPM (vital, limit 1); tongue: 7.7 nTPM (protected, limit 3); smooth muscle: 7.5 nTPM (vital, limit 1); bone marrow: 7.3 nTPM (vital, limit 1); heart muscle: 6.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GATC,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000257987,True,compatible,,True,True,True,,0.35,0.248357,0.240196,0,80,unavailable,0.2,1.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPMIP11,current_adaptive,True,False,True,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y,Chang 2019 · TGCT;Gong 2021 · reproductive coding,False,True,True,True,True,gained,selectivity_revised
ENSG00000258223,True,compatible,,True,True,True,,0.346032,0.3,0.246032,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PRSS58,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000258289,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 53.8538% (minimum 65%, Missing); adrenal gland: 57.1279% (minimum 75%, Missing); amygdala: 62.5000% (minimum 75%, Missing); basal ganglia: 65.3477% (minimum 75%, Missing); bone marrow: 56.0123% (minimum 75%, Missing); cerebellum: 74.6575% (minimum 75%, Missing); cerebral cortex: 63.2985% (minimum 75%, Missing); choroid plexus: 57.4289% (minimum 75%, Missing); colon: 56.3017% (minimum 70%, Missing); duodenum: 64.8038% (minimum 75%, Missing); esophagus: 62.5000% (minimum 70%, Missing); heart muscle: 48.9228% (minimum 75%, Missing); hippocampal formation: 63.8921% (minimum 75%, Missing); hypothalamus: 63.9671% (minimum 75%, Missing); kidney: 62.2146% (minimum 75%, Missing); liver: 51.6098% (minimum 75%, Missing); lung: 65.7419% (minimum 75%, Missing); lymph node: 56.5940% (minimum 70%, Missing); midbrain: 59.3036% (minimum 75%, Missing); pancreas: 65.0358% (minimum 75%, Missing); parathyroid gland: 55.2178% (minimum 70%, Missing); pituitary gland: 68.9001% (minimum 75%, Missing); rectum: 60.5556% (minimum 70%, Missing); retina: 60.3544% (minimum 75%, Missing); salivary gland: 67.9551% (minimum 70%, Missing); skeletal muscle: 40.5204% (minimum 75%, Missing); small intestine: 63.0787% (minimum 75%, Missing); smooth muscle: 54.8290% (minimum 75%, Missing); spinal cord: 52.6570% (minimum 75%, Missing); spleen: 57.1279% (minimum 60%, Approved); stomach: 62.5000% (minimum 70%, Missing); thymus: 47.9332% (minimum 65%, Missing); thyroid gland: 63.8921% (minimum 65%, Missing); tongue: 51.2700% (minimum 70%, Missing); urinary bladder: 59.5628% (minimum 70%, Missing)",-0.170668,-0.1873,-0.344796,0,6,partial,80,51.8,59.2,"skeletal muscle: 80 nTPM (vital, limit 1); thymus: 59.2 nTPM (manageable, limit 5); heart muscle: 56.9 nTPM (vital, limit 1); tongue: 51.8 nTPM (protected, limit 3); liver: 51.1 nTPM (vital, limit 1); spinal cord: 49 nTPM (vital, limit 1); adipose tissue: 46.7 nTPM (manageable, limit 5); smooth muscle: 44.9 nTPM (vital, limit 1); parathyroid gland: 44.2 nTPM (protected, limit 3); bone marrow: 42.8 nTPM (vital, limit 1); colon: 42.3 nTPM (protected, limit 3); lymph node: 41.8 nTPM (protected, limit 3); spleen: 40.9 nTPM (manageable, limit 10); adrenal gland: 40.9 nTPM (vital, limit 1); choroid plexus: 40.4 nTPM (vital, limit 1); midbrain: 37.4 nTPM (vital, limit 1); urinary bladder: 37 nTPM (protected, limit 3); retina: 35.8 nTPM (vital, limit 1); rectum: 35.5 nTPM (protected, limit 3); kidney: 33.1 nTPM (vital, limit 1); stomach: 32.7 nTPM (protected, limit 3); amygdala: 32.7 nTPM (vital, limit 1); esophagus: 32.7 nTPM (protected, limit 3); small intestine: 31.9 nTPM (vital, limit 1); cerebral cortex: 31.6 nTPM (vital, limit 1); hippocampal formation: 30.8 nTPM (vital, limit 1); thyroid gland: 30.8 nTPM (manageable, limit 5); hypothalamus: 30.7 nTPM (vital, limit 1); duodenum: 29.6 nTPM (vital, limit 1); pancreas: 29.3 nTPM (vital, limit 1); skin: 29.2 nTPM (manageable, limit 5); basal ganglia: 28.9 nTPM (vital, limit 1); lung: 28.4 nTPM (vital, limit 1); salivary gland: 25.7 nTPM (protected, limit 3); pituitary gland: 24.6 nTPM (vital, limit 1); cerebellum: 18.5 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / basal cells: Medium (Approved); bronchus / ciliated cells (cell body): Medium (Approved); bronchus / ciliated cells (cilia axoneme): Low (Approved); bronchus / ciliated cells (tip of cilia): Low (Approved); bronchus / goblet cells: Medium (Approved); caudate / neuronal cells: Low (Approved); cerebellum / cells in granular layer: Low (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: Low (Approved); cerebral cortex / endothelial cells: Low (Approved); cerebral cortex / neuronal cells: Low (Approved); cerebral cortex / neuropil: Low (Approved); colon / endothelial cells: Medium (Approved); colon / glandular cells: Medium (Approved); colon / peripheral nerve/ganglion: Medium (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Medium (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / neuronal cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / cholangiocytes: Low (Approved); liver / hepatocytes: Low (Approved); lung / alveolar cells: Low (Approved); lung / macrophages: Medium (Approved); lymph node / germinal center cells: Low (Approved); lymph node / non-germinal center cells: Medium (Approved); nasopharynx / basal cells: Medium (Approved); nasopharynx / ciliated cells (cell body): Medium (Approved); nasopharynx / ciliated cells (tip of cilia): Medium (Approved); nasopharynx / goblet cells: Medium (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Medium (Approved); parathyroid gland / glandular cells: Medium (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Medium (Approved); skin 1 / fibroblasts: Low (Approved); skin 1 / keratinocytes: Medium (Approved); skin 1 / Langerhans: Medium (Approved); skin 2 / epidermal cells: Medium (Approved); small intestine / glandular cells: Medium (Approved); smooth muscle / smooth muscle cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Medium (Approved); stomach 1 / glandular cells: Medium (Approved); stomach 2 / glandular cells: Medium (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Medium (Approved),62,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CHURC1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000258366,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 58.5366% (minimum 75%, Missing); bone marrow: 64.8649% (minimum 75%, Missing); cerebellum: 39.8340% (minimum 75%, Missing); cerebral cortex: 61.9355% (minimum 75%, Missing); colon: 53.6313% (minimum 70%, Missing); duodenum: 75.0000% (minimum 75%, Missing); esophagus: 68.0851% (minimum 70%, Missing); heart muscle: 71.6418% (minimum 75%, Missing); hypothalamus: 75.0000% (minimum 75%, Missing); kidney: 70.5882% (minimum 75%, Missing); liver: 67.1329% (minimum 75%, Missing); lung: 62.3377% (minimum 75%, Missing); pancreas: 61.5385% (minimum 75%, Missing); pituitary gland: 44.6512% (minimum 75%, Missing); salivary gland: 63.1579% (minimum 70%, Missing); skeletal muscle: 68.0851% (minimum 75%, Missing); small intestine: 62.7451% (minimum 75%, Missing); spleen: 61.9355% (minimum 65%, Missing); stomach: 60.0000% (minimum 70%, Missing); thyroid gland: 55.8140% (minimum 65%, Missing); urinary bladder: 60.3774% (minimum 70%, Missing)",-0.0918605,-0.163687,-0.35166,0,80,unavailable,14.5,8.3,7.6,"cerebellum: 14.5 nTPM (vital, limit 1); pituitary gland: 11.9 nTPM (vital, limit 1); colon: 8.3 nTPM (protected, limit 3); thyroid gland: 7.6 nTPM (manageable, limit 5); adrenal gland: 6.8 nTPM (vital, limit 1); stomach: 6.4 nTPM (protected, limit 3); urinary bladder: 6.3 nTPM (protected, limit 3); pancreas: 6 nTPM (vital, limit 1); cerebral cortex: 5.9 nTPM (vital, limit 1); spleen: 5.9 nTPM (manageable, limit 5); lung: 5.8 nTPM (vital, limit 1); small intestine: 5.7 nTPM (vital, limit 1); salivary gland: 5.6 nTPM (protected, limit 3); bone marrow: 5.2 nTPM (vital, limit 1); liver: 4.7 nTPM (vital, limit 1); skeletal muscle: 4.5 nTPM (vital, limit 1); esophagus: 4.5 nTPM (protected, limit 3); kidney: 4 nTPM (vital, limit 1); heart muscle: 3.8 nTPM (vital, limit 1); duodenum: 3.2 nTPM (vital, limit 1); hypothalamus: 3.2 nTPM (vital, limit 1); basal ganglia: 3.1 nTPM (vital, limit 1); choroid plexus: 2.4 nTPM (vital, limit 1); hippocampal formation: 2.3 nTPM (vital, limit 1); spinal cord: 2 nTPM (vital, limit 1); amygdala: 1.9 nTPM (vital, limit 1); midbrain: 1.8 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); smooth muscle: 1.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RTEL1,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000258405,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"retina: 68.1319% (minimum 75%, Missing)",0.13481,0.161111,-0.0686813,0,80,unavailable,2.9,1,1.7,"retina: 2.9 nTPM (vital, limit 1); cerebral cortex: 1.4 nTPM (vital, limit 1); heart muscle: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF578,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000258436,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0.2,0,0,,,50,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RNASE12,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021);da Silva 2017 · CT;da Silva 2017 · testis-biased",True,True,True,True,True,unchanged,
ENSG00000258597,False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,SERPINA2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000258713,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347636,0.3,0.23752,0,80,unavailable,1.6,0,0.3,"retina: 1.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C20orf141,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · preferential;Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000258992,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0,0,,,55,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TSPY1,current_adaptive,True,False,True,True,10.1002/cam4.2223;10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;Loriot 2025 · strict;Wang 2016;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000259060,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259060,current_adaptive,True,False,True,True,10.1038/ncomms10499,Wang 2016,True,True,True,True,True,unchanged,
ENSG00000259224,True,compatible,,True,True,True,,0.35,0.3,0.175926,0,80,unavailable,0.4,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SLC35G6,current_adaptive,True,False,True,False,10.1136/jitc-2023-007935,Carter 2023,False,True,True,True,True,gained,selectivity_revised
ENSG00000259316,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000259316,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,False,False,False,False,unchanged,
ENSG00000259571,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"choroid plexus: 33.3333% (minimum 75%, Missing); heart muscle: 50.0000% (minimum 75%, Missing)",0.35,0.3,-0.416667,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,BLID,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000260286,True,compatible,,True,True,True,,0.305882,0.284848,0.178571,0,80,unavailable,1,0.2,0.6,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ARMH2,current_adaptive,True,False,True,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,True,True,True,True,gained,selectivity_revised
ENSG00000260287,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.280695,0.153915,0,2,partial,2.7,1.2,1.4,"kidney: 2.7 nTPM (vital, limit 1); hippocampal formation: 1.1 nTPM (vital, limit 1)",kidney / cells in tubules: Low (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TBC1D3G,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000260456,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,,0.333051,0.270472,0.208212,0,10,partial,6.8,3,2.4,"liver: 6.8 nTPM (vital, limit 3); midbrain: 4.3 nTPM (vital, limit 1); skeletal muscle: 4.2 nTPM (vital, limit 3); cerebral cortex: 4.1 nTPM (vital, limit 3); amygdala: 3.9 nTPM (vital, limit 1); adrenal gland: 3.7 nTPM (vital, limit 3); basal ganglia: 3.4 nTPM (vital, limit 1); bone marrow: 3.3 nTPM (vital, limit 3); hippocampal formation: 3.1 nTPM (vital, limit 1); hypothalamus: 3.1 nTPM (vital, limit 1); pancreas: 3.1 nTPM (vital, limit 3); spinal cord: 3.1 nTPM (vital, limit 1); pituitary gland: 2.2 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); duodenum: 1.4 nTPM (vital, limit 1)",colon / endocrine cells: High (Supported); duodenum / endocrine cells: High (Supported); duodenum / glands of Brunner: Medium (Supported); rectum / endocrine cells: High (Supported); small intestine / endocrine cells: High (Supported),74,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / endocrine cells; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C16orf95,current_adaptive,True,False,False,False,10.1002/cam4.2223,Chang 2019 · TGCT,False,False,False,False,False,unchanged,
ENSG00000260596,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.25,0.118182,0,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; salivary gland; skin; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,DUX4,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000260734,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TLE7,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000261341,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.310256,0.298575,0.246209,0,80,unavailable,0.8,0.3,8.7,"skin: 8.7 nTPM (manageable, limit 5)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,SMIM47,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000261509,True,compatible,,True,True,True,,0.35,0.3,0.227273,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TP53TG3B,current_adaptive,True,False,True,False,10.1038/ncomms10499;10.18632/oncotarget.21715,Wang 2016;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000261649,True,compatible,,True,True,True,,0.34631,0.3,0.235401,0,80,unavailable,0.4,0,0.1,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GOLGA6L7,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Gong 2021 · reproductive coding;Loriot 2025 · strict,False,True,True,True,True,gained,selectivity_revised
ENSG00000261739,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.292857,0.242857,0.075,0,80,unavailable,0.7,0.2,0.2,,,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,GOLGA8S,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000261873,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,"retina: 20.4545% (minimum 75%, Missing)",0.314286,0.3,-0.545455,0,80,unavailable,10.5,0,0.1,"retina: 10.5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review,spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,SMIM36,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000261949,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"cerebellum: 72.2222% (minimum 75%, Missing); retina: 68.4211% (minimum 75%, Missing)",0.35,0.3,-0.0657895,0,80,unavailable,0.6,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GFY,current_adaptive,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict,False,False,False,False,False,unchanged,
ENSG00000262246,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"adipose tissue: 64.0288% (minimum 65%, Uncertain); adrenal gland: 63.5714% (minimum 75%, Uncertain); amygdala: 65.9259% (minimum 75%, Missing); basal ganglia: 52.5591% (minimum 75%, Missing); bone marrow: 27.9874% (minimum 75%, Missing); cerebellum: 68.2864% (minimum 75%, Uncertain); cerebral cortex: 60.4072% (minimum 75%, Uncertain); colon: 57.4194% (minimum 70%, Missing); duodenum: 64.4928% (minimum 75%, Missing); heart muscle: 70.2632% (minimum 75%, Uncertain); hippocampal formation: 56.4482% (minimum 75%, Missing); hypothalamus: 67.2544% (minimum 75%, Missing); kidney: 63.8756% (minimum 75%, Missing); lung: 50.0000% (minimum 75%, Missing); lymph node: 52.9762% (minimum 70%, Missing); midbrain: 63.2701% (minimum 75%, Missing); pancreas: 71.7742% (minimum 75%, Missing); pituitary gland: 67.0854% (minimum 75%, Missing); salivary gland: 67.2544% (minimum 70%, Uncertain); small intestine: 46.9244% (minimum 75%, Missing); spinal cord: 56.8085% (minimum 75%, Missing); spleen: 32.6007% (minimum 65%, Missing); stomach: 64.1827% (minimum 70%, Missing); urinary bladder: 65.4412% (minimum 70%, Uncertain)",-0.323993,-0.170238,-0.470126,0,2,partial,68.7,23.7,55.2,"bone marrow: 68.7 nTPM (vital, limit 1); spleen: 55.2 nTPM (manageable, limit 5); small intestine: 30.2 nTPM (vital, limit 1); lung: 26.7 nTPM (vital, limit 1); basal ganglia: 24.1 nTPM (vital, limit 1); lymph node: 23.7 nTPM (protected, limit 3); hippocampal formation: 20.6 nTPM (vital, limit 1); spinal cord: 20.3 nTPM (vital, limit 1); colon: 19.8 nTPM (protected, limit 3); cerebral cortex: 17.5 nTPM (vital, limit 1); midbrain: 15.5 nTPM (vital, limit 1); adrenal gland: 15.3 nTPM (vital, limit 1); kidney: 15.1 nTPM (vital, limit 1); adipose tissue: 15 nTPM (manageable, limit 5); stomach: 14.9 nTPM (protected, limit 3); duodenum: 14.7 nTPM (vital, limit 1); urinary bladder: 14.1 nTPM (protected, limit 3); thyroid gland: 14 nTPM (manageable, limit 5); amygdala: 13.8 nTPM (vital, limit 1); pituitary gland: 13.1 nTPM (vital, limit 1); hypothalamus: 13 nTPM (vital, limit 1); salivary gland: 13 nTPM (protected, limit 3); cerebellum: 12.4 nTPM (vital, limit 1); skin: 11.3 nTPM (manageable, limit 5); heart muscle: 11.3 nTPM (vital, limit 1); esophagus: 10.6 nTPM (protected, limit 3); thymus: 10.6 nTPM (manageable, limit 5); pancreas: 10.5 nTPM (vital, limit 1); liver: 8.6 nTPM (vital, limit 1); skeletal muscle: 6.2 nTPM (vital, limit 1); choroid plexus: 6.1 nTPM (vital, limit 1); smooth muscle: 5.3 nTPM (vital, limit 1); rectum: 4.5 nTPM (protected, limit 3); parathyroid gland: 4.4 nTPM (protected, limit 3); retina: 1.4 nTPM (vital, limit 1)",bone marrow / hematopoietic cells: Low (Uncertain); bronchus / respiratory epithelial cells: Medium (Uncertain); colon / glandular cells: High (Uncertain); duodenum / glandular cells: High (Uncertain); kidney / cells in glomeruli: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Low (Uncertain); lymph node / non-germinal center cells: Medium (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); rectum / glandular cells: High (Uncertain); skeletal muscle / myocytes: Medium (Uncertain); skin 2 / epidermal cells: Low (Uncertain); small intestine / glandular cells: High (Uncertain); smooth muscle / smooth muscle cells: Medium (Uncertain); spleen / cells in red pulp: Medium (Uncertain); stomach 1 / glandular cells: Medium (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; lymph node / non-germinal center cells; salivary gland; skin; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CORO7,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000262576,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adipose tissue: 46.8750% (minimum 65%, Missing); adrenal gland: 53.5714% (minimum 75%, Missing); amygdala: 50.0000% (minimum 75%, Missing); basal ganglia: 40.5405% (minimum 75%, Missing); cerebellum: 44.1176% (minimum 75%, Missing); cerebral cortex: 31.2500% (minimum 75%, Missing); colon: 65.2174% (minimum 70%, Missing); heart muscle: 51.7241% (minimum 75%, Missing); hippocampal formation: 55.5556% (minimum 75%, Missing); hypothalamus: 55.5556% (minimum 75%, Missing); lung: 60.0000% (minimum 75%, Missing); midbrain: 57.6923% (minimum 75%, Missing); pancreas: 42.8571% (minimum 75%, Missing); parathyroid gland: 40.5405% (minimum 70%, Missing); pituitary gland: 60.0000% (minimum 75%, Missing); retina: 50.0000% (minimum 75%, Missing); salivary gland: 68.1818% (minimum 70%, Missing); skeletal muscle: 68.1818% (minimum 75%, Missing); smooth muscle: 51.7241% (minimum 75%, Missing); spinal cord: 53.5714% (minimum 75%, Missing); tongue: 62.5000% (minimum 70%, Missing); urinary bladder: 68.1818% (minimum 70%, Missing)",-0.18125,-0.294595,-0.4375,0,80,unavailable,3.3,2.2,1.7,"cerebral cortex: 3.3 nTPM (vital, limit 1); basal ganglia: 2.2 nTPM (vital, limit 1); pancreas: 2 nTPM (vital, limit 1); cerebellum: 1.9 nTPM (vital, limit 1); amygdala: 1.5 nTPM (vital, limit 1); retina: 1.5 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1); adrenal gland: 1.3 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1); hippocampal formation: 1.2 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,PCDHGA4,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000262874,False,excluded,positive_ihc_outside_permitted,True,True,True,,0.331651,0.290741,0.222727,0,1,partial,0.6,0.2,0.4,,adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebral cortex / endothelial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); duodenum / glandular cells: Low (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / macrophages: Medium (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); small intestine / glandular cells: Low (Uncertain); spleen / cells in red pulp: Medium (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 2 / glandular cells: Low (Uncertain),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review;thymic_function_review,appendix; gallbladder; lymph node; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C19orf84,current_adaptive,True,False,False,False,10.1002/cam4.2223;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Chang 2019 · TGCT;Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000266826,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,IGBP1C,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000267631,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted,True,True,True,"duodenum: 60.0000% (minimum 70%, Approved); pancreas: 10.3448% (minimum 70%, Approved); pituitary gland: 6.8182% (minimum 75%, Missing)",0.35,0.3,-0.681818,0,2,partial,4.1,0,0,"pituitary gland: 4.1 nTPM (vital, limit 1); pancreas: 2.6 nTPM (vital, limit 2)",pituitary gland / cells in anterior : High (Approved),54,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CGB1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000267855,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adrenal gland: 38.2374% (minimum 75%, Missing); amygdala: 39.5331% (minimum 75%, Missing); basal ganglia: 37.9061% (minimum 75%, Missing); bone marrow: 60.9049% (minimum 75%, Missing); cerebellum: 58.7248% (minimum 75%, Missing); cerebral cortex: 42.3387% (minimum 75%, Missing); choroid plexus: 23.0871% (minimum 75%, Missing); colon: 53.7359% (minimum 70%, Missing); duodenum: 69.1700% (minimum 75%, Missing); esophagus: 48.3871% (minimum 70%, Missing); heart muscle: 24.3959% (minimum 75%, Missing); hippocampal formation: 46.1741% (minimum 75%, Missing); hypothalamus: 45.6919% (minimum 75%, Missing); kidney: 37.9335% (minimum 75%, Missing); liver: 39.2084% (minimum 75%, Missing); lung: 63.5593% (minimum 75%, Missing); lymph node: 64.5756% (minimum 70%, Missing); midbrain: 40.3536% (minimum 75%, Missing); pancreas: 59.3891% (minimum 75%, Missing); parathyroid gland: 34.5168% (minimum 70%, Missing); pituitary gland: 38.4334% (minimum 75%, Missing); rectum: 61.8375% (minimum 70%, Missing); retina: 62.7240% (minimum 75%, Missing); salivary gland: 55.4382% (minimum 70%, Missing); skeletal muscle: 18.1347% (minimum 75%, Missing); skin: 63.7910% (minimum 65%, Missing); small intestine: 61.4035% (minimum 75%, Missing); smooth muscle: 70.5645% (minimum 75%, Missing); spinal cord: 54.4606% (minimum 75%, Missing); spleen: 56.1497% (minimum 65%, Missing); stomach: 49.6689% (minimum 70%, Missing); thymus: 56.9414% (minimum 65%, Missing); thyroid gland: 56.6955% (minimum 65%, Missing); tongue: 18.4017% (minimum 70%, Missing); urinary bladder: 60.4143% (minimum 70%, Missing)",-0.0885027,-0.515983,-0.568653,0,6,partial,237,232.8,41,"skeletal muscle: 237 nTPM (vital, limit 1); tongue: 232.8 nTPM (protected, limit 3); choroid plexus: 174.9 nTPM (vital, limit 1); heart muscle: 162.7 nTPM (vital, limit 1); parathyroid gland: 99.6 nTPM (protected, limit 3); basal ganglia: 86 nTPM (vital, limit 1); kidney: 85.9 nTPM (vital, limit 1); adrenal gland: 84.8 nTPM (vital, limit 1); pituitary gland: 84.1 nTPM (vital, limit 1); liver: 81.4 nTPM (vital, limit 1); amygdala: 80.3 nTPM (vital, limit 1); midbrain: 77.6 nTPM (vital, limit 1); cerebral cortex: 71.5 nTPM (vital, limit 1); hypothalamus: 62.4 nTPM (vital, limit 1); hippocampal formation: 61.2 nTPM (vital, limit 1); esophagus: 56 nTPM (protected, limit 3); stomach: 53.2 nTPM (protected, limit 3); colon: 45.2 nTPM (protected, limit 3); spinal cord: 43.9 nTPM (vital, limit 1); salivary gland: 42.2 nTPM (protected, limit 3); spleen: 41 nTPM (manageable, limit 5); thyroid gland: 40.1 nTPM (manageable, limit 5); thymus: 39.7 nTPM (manageable, limit 5); adipose tissue: 38.2 nTPM (manageable, limit 30); cerebellum: 36.9 nTPM (vital, limit 1); pancreas: 35.9 nTPM (vital, limit 1); urinary bladder: 34.4 nTPM (protected, limit 3); bone marrow: 33.7 nTPM (vital, limit 1); small intestine: 33 nTPM (vital, limit 1); rectum: 32.4 nTPM (protected, limit 3); retina: 31.2 nTPM (vital, limit 1); lung: 30.1 nTPM (vital, limit 1); skin: 29.8 nTPM (manageable, limit 5); lymph node: 28.8 nTPM (protected, limit 3); duodenum: 23.4 nTPM (vital, limit 1); smooth muscle: 21.9 nTPM (vital, limit 1)",adrenal gland / glandular cells: High (Enhanced); bone marrow / hematopoietic cells: Low (Enhanced); bronchus / respiratory epithelial cells: High (Enhanced); caudate / glial cells: Low (Enhanced); caudate / neuronal cells: High (Enhanced); cerebellum / cells in granular layer: High (Enhanced); cerebellum / cells in molecular layer: Medium (Enhanced); cerebellum / Purkinje cells: High (Enhanced); cerebral cortex / glial cells: Medium (Enhanced); cerebral cortex / neuronal cells: High (Enhanced); cerebral cortex / neuropil: Medium (Enhanced); colon / endothelial cells: Medium (Enhanced); colon / glandular cells: High (Enhanced); duodenum / glandular cells: High (Enhanced); esophagus / squamous epithelial cells: Medium (Enhanced); heart muscle / cardiomyocytes: High (Enhanced); hippocampus / glial cells: Low (Enhanced); hippocampus / neuronal cells: High (Enhanced); kidney / cells in glomeruli: Medium (Enhanced); kidney / cells in tubules: High (Enhanced); liver / cholangiocytes: Medium (Enhanced); liver / hepatocytes: Medium (Enhanced); lung / alveolar cells type I: Medium (Enhanced); lung / alveolar cells type II: Medium (Enhanced); lung / macrophages: Medium (Enhanced); lymph node / germinal center cells: Medium (Enhanced); lymph node / non-germinal center cells: Low (Enhanced); nasopharynx / respiratory epithelial cells: Medium (Enhanced); oral mucosa / squamous epithelial cells: Medium (Enhanced); pancreas / exocrine glandular cells: Medium (Enhanced); pancreas / pancreatic endocrine cells: Medium (Enhanced); parathyroid gland / glandular cells: Medium (Enhanced); rectum / glandular cells: High (Enhanced); salivary gland / glandular cells: Medium (Enhanced); skeletal muscle / myocytes: Medium (Enhanced); skin 1 / cells in basal layer: Medium (Enhanced); skin 1 / cells in granular layer: Medium (Enhanced); skin 1 / cells in spinous layer: Medium (Enhanced); skin 1 / endothelial cells: Low (Enhanced); skin 1 / langerhans cells: Medium (Enhanced); skin 1 / lymphocytes: Low (Enhanced); skin 1 / vascular mural cells: Low (Enhanced); skin 2 / arrector pili muscle cells: Low (Enhanced); skin 2 / cells in basal layer: Medium (Enhanced); skin 2 / cells in granular layer: Medium (Enhanced); skin 2 / cells in spinous layer: Medium (Enhanced); skin 2 / endothelial cells: Low (Enhanced); skin 2 / langerhans cells: Medium (Enhanced); skin 2 / lymphocytes: Low (Enhanced); skin 2 / sebaceous glands: Medium (Enhanced); skin 2 / vascular mural cells: Low (Enhanced); small intestine / glandular cells: High (Enhanced); smooth muscle / smooth muscle cells: Medium (Enhanced); soft tissue 1 / fibroblasts: Medium (Enhanced); soft tissue 2 / fibroblasts: Low (Enhanced); spleen / cells in red pulp: Low (Enhanced); spleen / cells in white pulp: Low (Enhanced); stomach 1 / glandular cells: High (Enhanced); stomach 2 / glandular cells: High (Enhanced); thyroid gland / glandular cells: High (Enhanced); urinary bladder / urothelial cells: High (Enhanced),75,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / cells in basal layer; skin 1 / cells in granular layer; skin 1 / cells in spinous layer; skin 1 / endothelial cells; skin 1 / langerhans cells; skin 1 / lymphocytes; skin 1 / melanocytes; skin 1 / vascular mural cells; skin 2 / arrector pili muscle cells; skin 2 / cells in basal layer; skin 2 / cells in granular layer; skin 2 / cells in spinous layer; skin 2 / endothelial cells; skin 2 / hair follicles; skin 2 / langerhans cells; skin 2 / lymphocytes; skin 2 / melanocytes; skin 2 / sebaceous glands; skin 2 / vascular mural cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NDUFA7,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000267978,True,compatible,,True,True,True,,0.329798,0.289796,0.239796,0,80,unavailable,0.1,0.1,0.2,,,0,not_established,required,in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEA9B,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000268009,True,compatible,,True,True,True,,0.35,0.3,0.189394,0,3,partial,0.2,0.1,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SSX4,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000268223,False,excluded,reproductive_selectivity_below_threshold;existing_nomination_or_manual_review,True,True,True,"bone marrow: 40.0000% (minimum 75%, Missing); kidney: 66.6667% (minimum 75%, Missing); lung: 50.0000% (minimum 75%, Missing); lymph node: 50.0000% (minimum 70%, Missing)",0.0166667,-0.2,-0.35,0,80,unavailable,0.3,0.2,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ARL14EPL,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000268447,True,compatible,,True,True,True,,0.35,0.3,0.243976,0,2,partial,0.1,0,0.3,,,55,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SSX2B,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000268480,False,excluded,reproductive_selectivity_below_threshold;incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,"bone marrow: 66.6667% (minimum 75%, Missing)",0.15,0.142105,-0.0833333,9,80,unavailable,0.8,0.3,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,NFILZ,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive noncoding,False,False,False,False,False,unchanged,
ENSG00000268606,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MAGEA2,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000268629,True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX13A,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000268651,True,compatible,,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0.1,,,52,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CTAG1A,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000268696,False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.242857,0.220588,9,80,unavailable,0.1,0.2,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF723,current_adaptive,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict,False,False,False,False,False,unchanged,
ENSG00000268738,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.31,0.157143,0.125912,0,3,partial,1.7,2,1.1,"basal ganglia: 1.7 nTPM (vital, limit 1); choroid plexus: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.6 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1)",,54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HSFX2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000268902,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"lymph node: 50.0000% (minimum 70%, Missing); skin: 58.8235% (minimum 65%, Missing); spleen: 62.5000% (minimum 65%, Missing)",-0.0617647,-0.2,0.159091,0,80,unavailable,0.1,1,0.7,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review,lymph node; skin; spleen; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CSAG2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000268916,False,excluded,reproductive_selectivity_below_threshold,True,True,True,"spleen: 63.3333% (minimum 65%, Missing)",-0.0166667,0.045098,0.154762,0,80,unavailable,0.4,1.3,2.2,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CSAG3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000268940,False,excluded,positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.185484,0,3,partial,0.8,0,0,,skin 2 / epidermal cells: Low (Supported),53,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin 2 / epidermal cells,False,CT45A family target with HPA basal-ganglia RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,CT45A family target with HPA basal-ganglia RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,,,CT45A1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000268964,True,compatible,,True,True,True,,0.337805,0.3,0.19186,0,80,unavailable,0.5,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ERVV-2,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,True,True,True,True,gained,selectivity_revised
ENSG00000268988,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPANXN2,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000268994,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.33759,0.29791,0.23759,0,80,unavailable,1.2,0.2,1.2,"retina: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,FAM236B,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000269058,True,compatible,,True,True,True,,0.348415,0.3,0.25,0,2,partial,0.1,0,0.1,,,53,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CALR3,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000269096,False,excluded,rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.05,0,4,partial,2.3,0,0,"hippocampal formation: 2.3 nTPM (vital, limit 1); amygdala: 2.1 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); spinal cord: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); midbrain: 1.3 nTPM (vital, limit 1)",heart muscle / cardiomyocytes: Low (Supported),52,not_established,not_triggered,,,False,CT45A family target with hippocampal RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,CT45A family target with hippocampal RNA/protein signal; keep explicit clinical tier while excluding from strict defaults.,False,,,CT45A3,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000269405,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293289,0.0722222,0,80,unavailable,3.2,0.1,0,"pituitary gland: 3.2 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NXF2,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict,False,False,False,False,False,unchanged,
ENSG00000269437,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.293289,0.110465,0,80,unavailable,2.4,0.1,0,"pituitary gland: 2.4 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,NXF2B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000269502,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 73.5294% (minimum 75%, Missing); basal ganglia: 58.1395% (minimum 75%, Missing); cerebellum: 73.5294% (minimum 75%, Missing); cerebral cortex: 43.8596% (minimum 75%, Missing); hypothalamus: 69.4444% (minimum 75%, Missing); pituitary gland: 59.5238% (minimum 75%, Missing); retina: 52.0833% (minimum 75%, Missing); thyroid gland: 54.3478% (minimum 65%, Missing)",-0.106522,0.08125,-0.311404,0,80,unavailable,3.2,0.7,2.1,"cerebral cortex: 3.2 nTPM (vital, limit 1); retina: 2.3 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); pituitary gland: 1.7 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;thymic_function_review,gallbladder; lymph node; salivary gland; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,DMRTC1,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000269526,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.34359,0.287261,0.151163,0,80,unavailable,1.7,0.2,0.1,"kidney: 1.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ERVV-1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,"Gong 2021 · reproductive coding;Gong et al., Nature Communications (2021)",False,False,False,False,False,unchanged,
ENSG00000269586,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.115385,0,3,partial,1.4,0,0,"hippocampal formation: 1.4 nTPM (vital, limit 1); amygdala: 1.2 nTPM (vital, limit 1); spinal cord: 1.1 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT45A10,current_adaptive,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000269791,True,compatible,,True,True,True,,0.35,0.3,0.25,0,2,partial,0.1,0,0,,,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SSX4B,current_adaptive,True,False,True,False,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000270379,True,compatible,,True,True,True,,0.310784,0.289899,0.23,0,80,unavailable,0.2,0.1,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;lymphatic_and_immune_function_review,lymph node; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HEATR9,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000270601,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,PRAMEF5,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000270806,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.347087,0.299027,0.239403,0,80,unavailable,1.1,0.1,0.3,"basal ganglia: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_guaranteed;skin_compartment_and_extent_review;thymic_function_review,skin; spleen; thymus,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,C17orf50,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000270946,False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.35,0.3,0.138889,0,3,unreliable,0.1,0,0,,heart muscle / cardiomyocytes: Low (Supported),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT45A9,current_adaptive,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000271321,True,compatible,,True,True,True,,0.342908,0.285915,0.242908,0,80,unavailable,0.1,0.2,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CTAGE6,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000271449,True,compatible,,True,True,True,,0.35,0.3,0.25,0,3,partial,0,0,0,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT45A2,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000272804,False,excluded,rna_above_tissue_ceiling;insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0.1,0,13.8,"skin: 13.8 nTPM (manageable, limit 5)",,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,KRTAP10-7,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000272968,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.336038,0.286038,0.232609,0,80,unavailable,1,0.8,0.8,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,RBAK-RBAKDN,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000273111,True,compatible,,True,True,True,,0.35,0.29902,0.247065,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LYPD4,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000273313,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,RBAKDN,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive noncoding,False,False,False,False,False,unchanged,
ENSG00000273696,True,compatible,,True,True,True,,0.25,0.3,0.15,0,3,partial,0.1,0,0.1,,,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT45A7,current_adaptive,True,False,True,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000273976,True,compatible,,True,True,True,,0.35,0.3,0.232206,0,80,unavailable,0.5,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GOLGA6L1,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000274102,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR4M2,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,gained,admission_only
ENSG00000274183,True,compatible,,True,True,True,,0.316102,0.282759,0.2,0,80,unavailable,0.6,0.2,0.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,H2AB1,current_adaptive,True,False,True,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000274209,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.342,0.292,0.175373,0,80,unavailable,1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;persistent_salivary_dysfunction_review,salivary gland; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ANTXRL,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000274274,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.35,0.3,0.224545,0,4,partial,1.4,0,0,"retina: 1.4 nTPM (vital, limit 1)",,52,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GAGE13,current_adaptive,True,False,False,False,10.1186/s12967-024-04918-0;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;Seager 2024 · panel;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000274391,True,compatible,,True,True,True,,0.35,0.3,0.25,0,1,partial,0,0.1,0.3,,,55,not_established,required,local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TPTE,current_adaptive,True,False,True,True,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Bruggeman 2018;Gong 2021 · reproductive coding;Jamin 2021;Jamin 2021 · core;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000274419,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;existing_nomination_or_manual_review,True,True,True,"adrenal gland: 69.6078% (minimum 70%, Approved); basal ganglia: 73.9583% (minimum 75%, Missing); cerebellum: 50.3546% (minimum 70%, Approved); choroid plexus: 51.0791% (minimum 75%, Missing); esophagus: 63.9640% (minimum 65%, Approved); liver: 68.2692% (minimum 70%, Approved); pancreas: 73.1959% (minimum 75%, Missing); pituitary gland: 69.6078% (minimum 75%, Missing); small intestine: 63.3929% (minimum 70%, Approved); urinary bladder: 67.6190% (minimum 70%, Missing)",0.0339286,-0.0238095,-0.239209,0,2,partial,7,4,4.1,"cerebellum: 7 nTPM (vital, limit 2); choroid plexus: 6.8 nTPM (vital, limit 1); small intestine: 4.1 nTPM (vital, limit 2); urinary bladder: 3.4 nTPM (protected, limit 3); liver: 3.3 nTPM (vital, limit 2); pituitary gland: 3.1 nTPM (vital, limit 1); adrenal gland: 3.1 nTPM (vital, limit 2); pancreas: 2.6 nTPM (vital, limit 1); cerebral cortex: 2.5 nTPM (vital, limit 2); basal ganglia: 2.5 nTPM (vital, limit 1); kidney: 2.4 nTPM (vital, limit 2); lung: 2.2 nTPM (vital, limit 2); retina: 2.2 nTPM (vital, limit 1); hypothalamus: 2.1 nTPM (vital, limit 1); hippocampal formation: 1.8 nTPM (vital, limit 1); amygdala: 1.8 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); spinal cord: 1.3 nTPM (vital, limit 1)",pancreas / exocrine glandular cells: Low (Approved); urinary bladder / urothelial cells: Low (Approved),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,gallbladder; gallbladder / glandular cells; lymph node; salivary gland; skin; spleen; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TBC1D3D,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000274600,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.313504,0.3,0.242481,0,7,partial,0.2,0.3,0.5,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,RIMBP3B,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000274618,False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"bone marrow: 20.0000% (minimum 75%, Missing); choroid plexus: 40.0000% (minimum 75%, Missing); colon: 66.6667% (minimum 70%, Missing); esophagus: 66.6667% (minimum 70%, Missing); lymph node: 50.0000% (minimum 70%, Missing); thymus: 22.2222% (minimum 65%, Missing)",-0.427778,-0.2,-0.55,0,4,partial,0.8,0.2,0.7,,adipose tissue / adipocytes: Low (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: Medium (Supported); caudate / glial cells: High (Supported); cerebellum / cells in granular layer: Low (Supported); cerebellum / cells in molecular layer: Medium (Supported); cerebral cortex / glial cells: High (Supported); cerebral cortex / neuronal cells: Low (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: Medium (Supported); heart muscle / cardiomyocytes: Medium (Supported); hippocampus / glial cells: Medium (Supported); kidney / cells in glomeruli: Medium (Supported); kidney / cells in tubules: Medium (Supported); liver / cholangiocytes: Low (Supported); liver / hepatocytes: Medium (Supported); lung / alveolar cells: Low (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: Medium (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: Medium (Supported); parathyroid gland / glandular cells: Medium (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: Medium (Supported); skeletal muscle / myocytes: Medium (Supported); skin 1 / keratinocytes: Medium (Supported); skin 2 / epidermal cells: Medium (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Low (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 2 / peripheral nerve: Low (Supported); spleen / cells in red pulp: Low (Supported); spleen / cells in white pulp: Medium (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: Medium (Supported); thyroid gland / glandular cells: Medium (Supported); urinary bladder / urothelial cells: Medium (Supported),52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / keratinocytes; skin 2 / epidermal cells; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,H4C6,current_adaptive,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000274764,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;existing_nomination_or_manual_review,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,PRAMEF27,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000274933,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.318919,0.285507,0.181507,0,4,partial,0.9,0.4,0.6,,,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TBC1D3I,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000275004,False,excluded,rna_above_tissue_ceiling,True,True,True,,0.222483,0.221986,0.0524691,0,80,unavailable,3.2,1.1,1.9,"retina: 3.2 nTPM (vital, limit 1); hypothalamus: 3 nTPM (vital, limit 1); cerebral cortex: 2.6 nTPM (vital, limit 1); cerebellum: 2.4 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); amygdala: 1.7 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); hippocampal formation: 1.5 nTPM (vital, limit 1); midbrain: 1.4 nTPM (vital, limit 1); spinal cord: 1.4 nTPM (vital, limit 1); pituitary gland: 1.3 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF280B,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1038/s41388-018-0357-2,Bruggeman 2018;Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000275111,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 62.6866% (minimum 75%, Missing); amygdala: 72.4138% (minimum 75%, Missing); basal ganglia: 70.0000% (minimum 75%, Missing); cerebellum: 65.6250% (minimum 75%, Missing); cerebral cortex: 63.6364% (minimum 75%, Missing); colon: 64.6154% (minimum 70%, Missing); duodenum: 67.7419% (minimum 75%, Missing); esophagus: 65.6250% (minimum 70%, Missing); heart muscle: 59.1549% (minimum 75%, Missing); hippocampal formation: 71.1864% (minimum 75%, Missing); hypothalamus: 72.4138% (minimum 75%, Missing); kidney: 62.6866% (minimum 75%, Missing); liver: 70.0000% (minimum 75%, Missing); lung: 64.6154% (minimum 75%, Missing); lymph node: 59.1549% (minimum 70%, Missing); midbrain: 72.4138% (minimum 75%, Missing); pancreas: 66.6667% (minimum 75%, Missing); parathyroid gland: 53.1646% (minimum 70%, Missing); pituitary gland: 70.0000% (minimum 75%, Missing); retina: 60.8696% (minimum 75%, Missing); salivary gland: 66.6667% (minimum 70%, Missing); skeletal muscle: 59.1549% (minimum 75%, Missing); skin: 60.0000% (minimum 65%, Missing); small intestine: 71.1864% (minimum 75%, Missing); smooth muscle: 62.6866% (minimum 75%, Missing); spinal cord: 70.0000% (minimum 75%, Missing); spleen: 60.8696% (minimum 65%, Missing); stomach: 64.6154% (minimum 70%, Missing); thymus: 57.5342% (minimum 65%, Missing); thyroid gland: 58.3333% (minimum 65%, Missing); tongue: 54.5455% (minimum 70%, Missing); urinary bladder: 65.6250% (minimum 70%, Missing)",-0.0746575,-0.168354,-0.158451,0,80,unavailable,2.9,3.7,3.1,"parathyroid gland: 3.7 nTPM (protected, limit 3); tongue: 3.5 nTPM (protected, limit 3); heart muscle: 2.9 nTPM (vital, limit 1); skeletal muscle: 2.9 nTPM (vital, limit 1); retina: 2.7 nTPM (vital, limit 1); smooth muscle: 2.5 nTPM (vital, limit 1); kidney: 2.5 nTPM (vital, limit 1); adrenal gland: 2.5 nTPM (vital, limit 1); cerebral cortex: 2.4 nTPM (vital, limit 1); lung: 2.3 nTPM (vital, limit 1); cerebellum: 2.2 nTPM (vital, limit 1); pancreas: 2.1 nTPM (vital, limit 1); duodenum: 2 nTPM (vital, limit 1); pituitary gland: 1.8 nTPM (vital, limit 1); basal ganglia: 1.8 nTPM (vital, limit 1); spinal cord: 1.8 nTPM (vital, limit 1); liver: 1.8 nTPM (vital, limit 1); hippocampal formation: 1.7 nTPM (vital, limit 1); small intestine: 1.7 nTPM (vital, limit 1); hypothalamus: 1.6 nTPM (vital, limit 1); amygdala: 1.6 nTPM (vital, limit 1); midbrain: 1.6 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF2,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000275113,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"stomach: 63.0273% (minimum 65%, Approved)",0.35,-0.019727,0.163669,0,4,partial,2.4,14.9,0.2,"stomach: 14.9 nTPM (protected, limit 4); retina: 2.4 nTPM (vital, limit 1)",,52,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GAGE2E,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · preferential;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000275489,True,compatible,,True,True,True,,0.339529,0.3,0.244737,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPMAP1,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000275520,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.344726,0.287565,0.240157,0,80,unavailable,1.5,1.9,0.8,"retina: 1.5 nTPM (vital, limit 1); pancreas: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review,appendix; gallbladder; lymph node; salivary gland; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,FAM236A,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000275722,True,compatible,,True,True,True,,0.35,0.3,0.243603,0,1,partial,0.3,0.2,1.1,,,55,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,lymph node; salivary gland; skin; spleen,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,LYZL6,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000275774,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity,False,False,True,,,,,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,HNRNPCL2,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000275793,True,compatible,,True,True,True,,0.315035,0.29639,0.239247,0,7,partial,0.3,0.7,1,,,50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,RIMBP3,current_adaptive,True,False,True,False,10.1038/s41388-018-0357-2;10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.18632/oncotarget.21715,Bruggeman 2018;Carter 2023;Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,True,True,True,True,gained,selectivity_revised
ENSG00000275954,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.306522,0.270588,0.166667,0,80,unavailable,0.6,0.2,0.3,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TBC1D3F,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000275969,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA31A3,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000276040,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA31A7,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000276234,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 74.2424% (minimum 75%, Missing); amygdala: 62.8205% (minimum 75%, Missing); basal ganglia: 61.2500% (minimum 75%, Missing); cerebellum: 49.0000% (minimum 75%, Missing); cerebral cortex: 56.3218% (minimum 75%, Missing); colon: 67.1233% (minimum 70%, Missing); heart muscle: 70.5036% (minimum 75%, Missing); hippocampal formation: 64.0523% (minimum 75%, Missing); hypothalamus: 61.2500% (minimum 75%, Missing); kidney: 72.0588% (minimum 75%, Missing); liver: 68.0556% (minimum 75%, Missing); midbrain: 61.2500% (minimum 75%, Missing); pancreas: 67.1233% (minimum 75%, Missing); pituitary gland: 68.5315% (minimum 75%, Missing); retina: 67.1233% (minimum 75%, Missing); skeletal muscle: 62.0253% (minimum 75%, Missing); small intestine: 65.3333% (minimum 75%, Missing); spinal cord: 61.6352% (minimum 75%, Missing); spleen: 64.9007% (minimum 65%, Missing); thyroid gland: 64.9007% (minimum 65%, Missing); urinary bladder: 67.1233% (minimum 70%, Missing)",-0.000993377,-0.0287671,-0.26,0,80,unavailable,10.2,4.8,5.3,"cerebellum: 10.2 nTPM (vital, limit 1); cerebral cortex: 7.6 nTPM (vital, limit 1); midbrain: 6.2 nTPM (vital, limit 1); basal ganglia: 6.2 nTPM (vital, limit 1); hypothalamus: 6.2 nTPM (vital, limit 1); spinal cord: 6.1 nTPM (vital, limit 1); skeletal muscle: 6 nTPM (vital, limit 1); amygdala: 5.8 nTPM (vital, limit 1); hippocampal formation: 5.5 nTPM (vital, limit 1); thyroid gland: 5.3 nTPM (manageable, limit 5); spleen: 5.3 nTPM (manageable, limit 5); small intestine: 5.2 nTPM (vital, limit 1); urinary bladder: 4.8 nTPM (protected, limit 3); colon: 4.8 nTPM (protected, limit 3); retina: 4.8 nTPM (vital, limit 1); pancreas: 4.8 nTPM (vital, limit 1); liver: 4.6 nTPM (vital, limit 1); pituitary gland: 4.5 nTPM (vital, limit 1); heart muscle: 4.1 nTPM (vital, limit 1); stomach: 4.1 nTPM (protected, limit 3); kidney: 3.8 nTPM (vital, limit 1); salivary gland: 3.8 nTPM (protected, limit 3); esophagus: 3.7 nTPM (protected, limit 3); adrenal gland: 3.4 nTPM (vital, limit 1); lung: 3.2 nTPM (vital, limit 1); choroid plexus: 2.5 nTPM (vital, limit 1); bone marrow: 2.5 nTPM (vital, limit 1); duodenum: 1.7 nTPM (vital, limit 1); smooth muscle: 1.4 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TADA2A,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021;Jamin 2021 · core,False,False,False,False,False,unchanged,
ENSG00000276240,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0.1,0.1,0.1,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;lymphatic_and_immune_function_review,appendix; lymph node; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR4E1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000276410,False,excluded,reproductive_selectivity_below_threshold;positive_ihc_outside_permitted;unresolved_positive_anatomy;family_exclusion,True,True,True,"bone marrow: 56.5217% (minimum 75%, Missing); choroid plexus: 72.2222% (minimum 75%, Missing); thymus: 56.5217% (minimum 65%, Missing)",-0.0847826,0.166667,-0.184783,0,4,partial,1,0.2,1,,adipose tissue / adipocytes: High (Supported); adrenal gland / glandular cells: High (Supported); bone marrow / hematopoietic cells: High (Supported); bronchus / respiratory epithelial cells: High (Supported); caudate / glial cells: High (Supported); caudate / neuronal cells: High (Supported); cerebellum / cells in granular layer: High (Supported); cerebellum / cells in molecular layer: High (Supported); cerebellum / Purkinje cells: Low (Supported); cerebral cortex / endothelial cells: Medium (Supported); cerebral cortex / glial cells: Medium (Supported); cerebral cortex / neuronal cells: High (Supported); colon / glandular cells: High (Supported); duodenum / glandular cells: High (Supported); esophagus / squamous epithelial cells: High (Supported); heart muscle / cardiomyocytes: High (Supported); hippocampus / glial cells: High (Supported); hippocampus / neuronal cells: High (Supported); kidney / cells in glomeruli: High (Supported); kidney / cells in tubules: High (Supported); liver / cholangiocytes: High (Supported); liver / hepatocytes: High (Supported); lung / alveolar cells: High (Supported); lung / macrophages: High (Supported); lymph node / germinal center cells: Medium (Supported); lymph node / non-germinal center cells: Medium (Supported); nasopharynx / respiratory epithelial cells: High (Supported); oral mucosa / squamous epithelial cells: High (Supported); pancreas / exocrine glandular cells: High (Supported); pancreas / pancreatic endocrine cells: High (Supported); parathyroid gland / glandular cells: High (Supported); rectum / glandular cells: High (Supported); salivary gland / glandular cells: High (Supported); skeletal muscle / myocytes: High (Supported); skin 1 / fibroblasts: High (Supported); skin 1 / keratinocytes: High (Supported); skin 1 / Langerhans: High (Supported); skin 2 / epidermal cells: High (Supported); small intestine / glandular cells: High (Supported); smooth muscle / smooth muscle cells: Medium (Supported); soft tissue 1 / chondrocytes: Medium (Supported); soft tissue 1 / fibroblasts: High (Supported); soft tissue 1 / peripheral nerve: High (Supported); soft tissue 2 / chondrocytes: High (Supported); soft tissue 2 / fibroblasts: High (Supported); soft tissue 2 / peripheral nerve: High (Supported); spleen / cells in red pulp: High (Supported); spleen / cells in white pulp: High (Supported); stomach 1 / glandular cells: High (Supported); stomach 2 / glandular cells: High (Supported); thyroid gland / glandular cells: High (Supported); urinary bladder / urothelial cells: High (Supported),53,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix / glandular cells; appendix / lymphoid tissue; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland / glandular cells; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil / germinal center cells; tonsil / non-germinal center cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,H2BC3,current_adaptive,False,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000276430,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"esophagus: 32.7982% (minimum 70%, Missing); salivary gland: 48.9726% (minimum 70%, Missing); skin: 25.3097% (minimum 65%, Missing)",-0.396903,-0.372018,0.149371,0,80,unavailable,1.6,29.3,42.2,"skin: 42.2 nTPM (manageable, limit 5); esophagus: 29.3 nTPM (protected, limit 3); salivary gland: 14.9 nTPM (protected, limit 3); small intestine: 1.6 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,FAM25C,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,False,False,False,False,False,unchanged,
ENSG00000276581,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,SPATA31A5,current_adaptive,True,False,True,True,10.18632/oncotarget.21715,da Silva 2017 · CT;da Silva 2017 · testis-biased,True,True,True,True,True,unchanged,
ENSG00000276747,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,PADI6,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000276950,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,GSTT4,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000277322,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,GOLGA6L6,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · CT;da Silva 2017 · testis-biased;da Silva 2017 · tumor proteomics,True,True,True,True,True,unchanged,
ENSG00000277462,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;unresolved_positive_anatomy,True,True,True,"adipose tissue: 51.1111% (minimum 65%, Missing); adrenal gland: 62.1622% (minimum 75%, Missing); amygdala: 69.6970% (minimum 75%, Missing); basal ganglia: 71.8750% (minimum 75%, Missing); cerebellum: 51.1111% (minimum 75%, Missing); cerebral cortex: 58.9744% (minimum 75%, Missing); colon: 60.5263% (minimum 70%, Missing); duodenum: 69.6970% (minimum 75%, Missing); esophagus: 65.7143% (minimum 70%, Missing); heart muscle: 69.6970% (minimum 75%, Missing); hippocampal formation: 71.8750% (minimum 75%, Missing); hypothalamus: 67.6471% (minimum 75%, Missing); kidney: 57.5000% (minimum 75%, Missing); liver: 58.9744% (minimum 75%, Uncertain); lung: 60.5263% (minimum 75%, Missing); lymph node: 62.1622% (minimum 70%, Missing); midbrain: 71.8750% (minimum 75%, Missing); pancreas: 56.0976% (minimum 75%, Missing); parathyroid gland: 60.5263% (minimum 70%, Missing); pituitary gland: 69.6970% (minimum 75%, Missing); rectum: 63.8889% (minimum 70%, Missing); retina: 52.2727% (minimum 75%, Missing); salivary gland: 60.5263% (minimum 70%, Missing); skeletal muscle: 71.8750% (minimum 75%, Missing); skin: 62.1622% (minimum 65%, Missing); small intestine: 60.5263% (minimum 75%, Missing); smooth muscle: 58.9744% (minimum 75%, Missing); spinal cord: 69.6970% (minimum 75%, Missing); spleen: 62.1622% (minimum 65%, Missing); stomach: 53.4884% (minimum 70%, Missing); thymus: 56.0976% (minimum 65%, Missing); thyroid gland: 62.1622% (minimum 65%, Missing); tongue: 62.1622% (minimum 70%, Missing); urinary bladder: 58.9744% (minimum 70%, Missing)",-0.138889,-0.165116,-0.238889,0,0,routine_complete,2.2,2,2.2,"cerebellum: 2.2 nTPM (vital, limit 1); retina: 2.1 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); kidney: 1.7 nTPM (vital, limit 1); cerebral cortex: 1.6 nTPM (vital, limit 1); liver: 1.6 nTPM (vital, limit 1); smooth muscle: 1.6 nTPM (vital, limit 1); lung: 1.5 nTPM (vital, limit 1); small intestine: 1.5 nTPM (vital, limit 1); adrenal gland: 1.4 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Uncertain); adrenal gland / glandular cells: Low (Uncertain); bronchus / respiratory epithelial cells: Low (Uncertain); caudate / glial cells: Low (Uncertain); caudate / neuronal cells: Medium (Uncertain); cerebellum / cells in granular layer: Low (Uncertain); cerebellum / cells in molecular layer: Medium (Uncertain); cerebellum / Purkinje cells: Medium (Uncertain); cerebral cortex / glial cells: Low (Uncertain); cerebral cortex / neuronal cells: Medium (Uncertain); cerebral cortex / neuropil: Low (Uncertain); colon / glandular cells: Low (Uncertain); colon / peripheral nerve/ganglion: Low (Uncertain); duodenum / glandular cells: Low (Uncertain); esophagus / squamous epithelial cells: Low (Uncertain); heart muscle / cardiomyocytes: Low (Uncertain); hippocampus / glial cells: Medium (Uncertain); hippocampus / neuronal cells: Medium (Uncertain); kidney / cells in tubules: Low (Uncertain); lung / alveolar cells: Medium (Uncertain); lung / macrophages: Medium (Uncertain); lymph node / germinal center cells: Low (Uncertain); lymph node / non-germinal center cells: Low (Uncertain); nasopharynx / respiratory epithelial cells: Low (Uncertain); pancreas / exocrine glandular cells: Low (Uncertain); pancreas / pancreatic endocrine cells: Low (Uncertain); parathyroid gland / glandular cells: Low (Uncertain); rectum / glandular cells: Low (Uncertain); salivary gland / glandular cells: Low (Uncertain); skeletal muscle / myocytes: Low (Uncertain); skin 1 / fibroblasts: Medium (Uncertain); skin 1 / keratinocytes: Low (Uncertain); skin 1 / Langerhans: Low (Uncertain); skin 2 / epidermal cells: Medium (Uncertain); small intestine / glandular cells: Low (Uncertain); smooth muscle / smooth muscle cells: Low (Uncertain); soft tissue 1 / fibroblasts: Medium (Uncertain); spleen / cells in red pulp: Low (Uncertain); spleen / cells in white pulp: Low (Uncertain); stomach 1 / glandular cells: Low (Uncertain); stomach 2 / glandular cells: Medium (Uncertain); thyroid gland / glandular cells: Medium (Uncertain); urinary bladder / urothelial cells: Low (Uncertain),54,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; appendix / lymphoid tissue; gallbladder; gallbladder / glandular cells; lymph node; lymph node / germinal center cells; lymph node / non-germinal center cells; salivary gland; salivary gland / glandular cells; skin; skin 1 / Langerhans; skin 1 / fibroblasts; skin 1 / keratinocytes; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil; tonsil / germinal center cells; tonsil / non-germinal center cells; tonsil / squamous epithelial cells,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF670,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000277535,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,4,partial,0,0,0,,,51,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,CT47C1,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000277745,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.306113,0.280707,0.218254,0,80,unavailable,1,0.6,1.4,,,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,H2AB3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000277865,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.237952,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,GOLGA6L22,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000278057,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.338636,0.3,0.238636,0,80,unavailable,0.1,0,0.1,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TEX28,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000278085,False,excluded,positive_ihc_outside_permitted;reviewed_unreliable_ihc,True,True,True,,0.35,0.3,0.159091,0,3,unreliable,0.1,0,0,,heart muscle / cardiomyocytes: Low (Supported),53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT45A8,current_adaptive,True,False,False,False,10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Loriot 2025 · strict;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000278289,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 14.2857% (minimum 75%, Missing); basal ganglia: 2.5000% (minimum 75%, Missing); cerebral cortex: 33.3333% (minimum 65%, Supported); hippocampal formation: 20.0000% (minimum 75%, Missing); hypothalamus: 7.6923% (minimum 75%, Missing); midbrain: 33.3333% (minimum 75%, Missing); pituitary gland: 7.6923% (minimum 75%, Missing); retina: 33.3333% (minimum 75%, Missing); spinal cord: 20.0000% (minimum 75%, Missing)",0.35,0.3,-0.725,0,3,partial,3.9,0,0,"basal ganglia: 3.9 nTPM (vital, limit 1); hypothalamus: 1.2 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1)",,53,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CT45A6,current_adaptive,True,False,False,False,10.1002/1878-0261.12900;10.1371/journal.pgen.1011734;10.18632/oncotarget.21715,Jamin 2021;Jamin 2021 · core;Loriot 2025 · strict;da Silva 2017 · CT;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000278318,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"adrenal gland: 56.7568% (minimum 75%, Missing); amygdala: 65.6250% (minimum 75%, Missing); basal ganglia: 60.0000% (minimum 75%, Missing); cerebellum: 70.0000% (minimum 75%, Missing); cerebral cortex: 61.7647% (minimum 75%, Missing); choroid plexus: 60.0000% (minimum 75%, Missing); heart muscle: 60.0000% (minimum 75%, Missing); hippocampal formation: 70.0000% (minimum 75%, Missing); hypothalamus: 65.6250% (minimum 75%, Missing); kidney: 72.4138% (minimum 75%, Missing); midbrain: 65.6250% (minimum 75%, Missing); parathyroid gland: 44.6809% (minimum 70%, Missing); pituitary gland: 63.6364% (minimum 75%, Missing); retina: 32.8125% (minimum 75%, Missing); smooth muscle: 72.4138% (minimum 75%, Missing); spinal cord: 70.0000% (minimum 75%, Missing); thyroid gland: 52.5000% (minimum 65%, Missing); tongue: 65.6250% (minimum 70%, Missing)",-0.125,-0.253191,-0.421875,0,80,unavailable,4.3,2.6,1.9,"retina: 4.3 nTPM (vital, limit 1); adrenal gland: 1.6 nTPM (vital, limit 1); basal ganglia: 1.4 nTPM (vital, limit 1); choroid plexus: 1.4 nTPM (vital, limit 1); heart muscle: 1.4 nTPM (vital, limit 1); cerebral cortex: 1.3 nTPM (vital, limit 1); pituitary gland: 1.2 nTPM (vital, limit 1); amygdala: 1.1 nTPM (vital, limit 1); hypothalamus: 1.1 nTPM (vital, limit 1); midbrain: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ZNF229,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000278522,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.310784,0.3,0.23,0,80,unavailable,0.1,0,0.2,,,0,not_established,required,local_control_not_guaranteed;skin_compartment_and_extent_review,skin,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,POTEB3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000278685,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.227273,0,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,IQCA1L,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000279169,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,PRAMEF13,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000279408,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR4N4C,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000282419,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TEX13D,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000282815,True,compatible,,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TEX13C,current_adaptive,True,False,True,True,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935;10.1371/journal.pgen.1011734,Carter 2023;Gong 2021 · reproductive coding;Loriot 2025 · strict,True,True,True,True,True,unchanged,
ENSG00000283093,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling,True,True,True,"amygdala: 46.6667% (minimum 75%, Missing); basal ganglia: 12.9630% (minimum 75%, Missing); cerebral cortex: 53.8462% (minimum 75%, Missing); hippocampal formation: 58.3333% (minimum 75%, Missing); hypothalamus: 13.2075% (minimum 75%, Missing); midbrain: 53.8462% (minimum 75%, Missing)",0.35,0.3,-0.62037,0,80,unavailable,4.7,0,0,"basal ganglia: 4.7 nTPM (vital, limit 1); hypothalamus: 4.6 nTPM (vital, limit 1)",,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,CENPVL2,current_adaptive,True,False,False,False,10.1371/journal.pgen.1011734,Loriot 2025 · strict,False,False,False,False,False,unchanged,
ENSG00000283205,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.283051,0.25,0,80,unavailable,0,0.1,0,,,0,not_established,required,local_control_not_established;persistent_salivary_dysfunction_review,salivary gland,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,ENSG00000283205,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000283268,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.338095,0.276471,0.235488,0,80,unavailable,1.1,1.8,0.9,"pituitary gland: 1.1 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review,appendix; gallbladder; lymph node; salivary gland; skin; spleen,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TEX54,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000283434,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,CSNK2A2IP,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000283439,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,SPEM3,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000283463,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.336486,0.293197,0.0939306,0,80,unavailable,2.7,0.1,0.2,"adrenal gland: 2.7 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;local_control_not_established;local_control_not_guaranteed;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,salivary gland; skin; spleen; thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,HSFX4,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000283516,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.208333,0,80,unavailable,0.3,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,LITAFD,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000283594,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,FAM236C,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000283599,True,compatible,,True,True,True,,0.35,0.3,0.22561,0,80,unavailable,0.2,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ENSG00000283599,current_adaptive,True,False,True,False,10.1038/s41467-021-22695-y;10.1136/jitc-2023-007935,Carter 2023;Gong 2021 · reproductive coding,False,True,True,True,True,gained,selectivity_revised
ENSG00000283697,False,excluded,rna_above_tissue_ceiling;existing_nomination_or_manual_review,True,True,True,,0.329021,0.3,0.171053,0,80,unavailable,1.2,0,0.3,"adrenal gland: 1.2 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;immune_cell_distribution_review;thymic_function_review,thymus,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,HSFX3,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000283758,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,0,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,PMIS2,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000284188,True,compatible,existing_nomination_or_manual_review,True,True,True,,0.35,0.288506,0.216292,0,80,unavailable,0.3,0.1,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,C1orf202,current_adaptive,True,False,False,False,10.1038/s41467-021-22695-y,Gong 2021 · reproductive coding,False,False,False,False,False,unchanged,
ENSG00000284609,False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR8B3,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000284680,False,unresolved,incomplete_routine_rna,True,True,True,,0.35,0.3,0.25,9,80,unavailable,0,0,0,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,OR8B2,current_adaptive,True,False,False,False,10.1038/ncomms10499;10.1038/s41467-021-22695-y;10.18632/oncotarget.21715,Gong 2021 · reproductive coding;Wang 2016;da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000284701,False,unresolved,incomplete_routine_rna;existing_nomination_or_manual_review,True,True,True,,0.35,0.3,0.25,9,4,partial,0,0,0,,,50,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,TMEM247,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000284723,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna;existing_nomination_or_manual_review,False,False,True,,,,,9,80,unavailable,0.1,0,0,,,0,not_established,not_triggered,,,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,Normal reproductive-expression nomination only; no cancer-associated nomination in the imported source sets. HPA restriction alone does not establish a CTA.,False,,,OR8S1,current_adaptive,True,False,False,False,10.18632/oncotarget.21715,da Silva 2017 · testis-biased,False,False,False,False,False,unchanged,
ENSG00000284770,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;positive_ihc_outside_permitted;incomplete_routine_rna;unresolved_positive_anatomy,True,True,True,"adipose tissue: 52.5424% (minimum 65%, Missing); adrenal gland: 42.4658% (minimum 75%, Missing); bone marrow: 58.4906% (minimum 75%, Missing); cerebral cortex: 63.2653% (minimum 75%, Missing); choroid plexus: 58.4906% (minimum 75%, Missing); colon: 44.9275% (minimum 70%, Missing); duodenum: 54.3860% (minimum 75%, Missing); esophagus: 47.6923% (minimum 70%, Missing); heart muscle: 38.7500% (minimum 75%, Missing); kidney: 46.9697% (minimum 75%, Missing); liver: 36.4706% (minimum 75%, Missing); lung: 62.0000% (minimum 70%, Approved); lymph node: 59.6154% (minimum 65%, Approved); pancreas: 63.2653% (minimum 75%, Missing); parathyroid gland: 51.6667% (minimum 70%, Missing); rectum: 50.0000% (minimum 70%, Missing); retina: 41.3333% (minimum 75%, Missing); salivary gland: 47.6923% (minimum 70%, Missing); skeletal muscle: 26.9565% (minimum 75%, Missing); skin: 59.6154% (minimum 65%, Missing); small intestine: 70.4545% (minimum 75%, Missing); smooth muscle: 62.0000% (minimum 70%, Approved); spleen: 60.7843% (minimum 65%, Missing); stomach: 45.5882% (minimum 70%, Missing); thymus: 60.7843% (minimum 65%, Missing); thyroid gland: 31.9588% (minimum 65%, Missing); tongue: 67.3913% (minimum 70%, Missing); urinary bladder: 55.3571% (minimum 70%, Missing)",-0.330412,-0.250725,-0.480435,9,5,partial,8.4,3.8,6.6,"skeletal muscle: 8.4 nTPM (vital, limit 1); thyroid gland: 6.6 nTPM (manageable, limit 5); liver: 5.4 nTPM (vital, limit 1); heart muscle: 4.9 nTPM (vital, limit 1); retina: 4.4 nTPM (vital, limit 1); adrenal gland: 4.2 nTPM (vital, limit 1); colon: 3.8 nTPM (protected, limit 3); stomach: 3.7 nTPM (protected, limit 3); kidney: 3.5 nTPM (vital, limit 1); esophagus: 3.4 nTPM (protected, limit 3); salivary gland: 3.4 nTPM (protected, limit 3); rectum: 3.1 nTPM (protected, limit 3); duodenum: 2.6 nTPM (vital, limit 1); choroid plexus: 2.2 nTPM (vital, limit 1); bone marrow: 2.2 nTPM (vital, limit 1); pancreas: 1.8 nTPM (vital, limit 1); cerebral cortex: 1.8 nTPM (vital, limit 1); small intestine: 1.3 nTPM (vital, limit 1)",adipose tissue / adipocytes: Medium (Approved); adrenal gland / glandular cells: Low (Approved); bone marrow / hematopoietic cells: Medium (Approved); bronchus / respiratory epithelial cells: Medium (Approved); caudate / glial cells: Low (Approved); cerebellum / cells in granular layer: Medium (Approved); cerebellum / cells in molecular layer: Low (Approved); cerebellum / Purkinje cells: High (Approved); cerebral cortex / endothelial cells: Medium (Approved); cerebral cortex / neuropil: Low (Approved); colon / peripheral nerve/ganglion: Low (Approved); duodenum / glandular cells: Medium (Approved); esophagus / squamous epithelial cells: Low (Approved); heart muscle / cardiomyocytes: Medium (Approved); hippocampus / glial cells: Low (Approved); kidney / cells in glomeruli: Low (Approved); kidney / cells in tubules: Medium (Approved); liver / hepatocytes: Medium (Approved); nasopharynx / respiratory epithelial cells: Low (Approved); oral mucosa / squamous epithelial cells: Medium (Approved); pancreas / exocrine glandular cells: Low (Approved); pancreas / pancreatic endocrine cells: Low (Approved); rectum / glandular cells: Medium (Approved); salivary gland / glandular cells: Medium (Approved); skeletal muscle / myocytes: Low (Approved); skin 1 / fibroblasts: Low (Approved); skin 2 / epidermal cells: Low (Approved); small intestine / glandular cells: Medium (Approved); soft tissue 1 / fibroblasts: Low (Approved); soft tissue 2 / fibroblasts: Low (Approved); spleen / cells in red pulp: High (Approved); spleen / cells in white pulp: High (Approved); stomach 1 / glandular cells: Low (Approved); stomach 2 / glandular cells: Low (Approved); thyroid gland / glandular cells: Medium (Approved); urinary bladder / urothelial cells: Low (Approved),50,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_established;local_control_not_guaranteed;lymphatic_and_immune_function_review;persistent_salivary_dysfunction_review;skin_compartment_and_extent_review;thymic_function_review,appendix; appendix / glandular cells; gallbladder; gallbladder / glandular cells; lymph node; salivary gland; salivary gland / glandular cells; skin; skin 1 / fibroblasts; skin 1 / melanocytes; skin 2 / epidermal cells; spleen; spleen / cells in red pulp; spleen / cells in white pulp; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,TBCE,current_adaptive,True,False,False,False,10.1002/1878-0261.12900,Jamin 2021,False,False,False,False,False,unchanged,
ENSG00000285077,False,excluded,reproductive_selectivity_below_threshold;rna_above_tissue_ceiling;incomplete_routine_rna,True,True,True,"adipose tissue: 60.0000% (minimum 65%, Missing); bone marrow: 5.6604% (minimum 75%, Missing); colon: 60.0000% (minimum 70%, Missing); duodenum: 75.0000% (minimum 75%, Missing); liver: 75.0000% (minimum 75%, Missing); lung: 75.0000% (minimum 75%, Missing); lymph node: 17.6471% (minimum 70%, Missing); rectum: 50.0000% (minimum 70%, Missing); retina: 75.0000% (minimum 75%, Missing); skin: 37.5000% (minimum 65%, Missing); small intestine: 50.0000% (minimum 75%, Missing); smooth muscle: 60.0000% (minimum 75%, Missing); spleen: 50.0000% (minimum 65%, Missing); stomach: 42.8571% (minimum 70%, Missing); thymus: 17.6471% (minimum 65%, Missing)",-0.473529,-0.523529,-0.693396,9,80,unavailable,5,1.4,1.4,"bone marrow: 5 nTPM (vital, limit 1)",,0,not_established,required,age_and_immune_reserve_review;asplenia_infection_risk_review;immune_cell_distribution_review;in_situ_inflammation_review;local_control_not_guaranteed;lymphatic_and_immune_function_review;skin_compartment_and_extent_review;thymic_function_review,appendix; gallbladder; lymph node; skin; spleen; thymus; tonsil,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,ARHGAP11B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,
ENSG00000293137,False,excluded,insufficient_positive_reproductive_evidence;unresolved_reproductive_selectivity;incomplete_routine_rna,False,False,True,,,,,50,80,unavailable,,,,,,0,not_established,not_triggered,,,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,True,Derived from HPA reproductive-restriction filters and never-expressed rescue policy.,False,,,MSL3B,current_adaptive,True,False,False,False,10.1038/s41388-018-0357-2,Bruggeman 2018,False,False,False,False,False,unchanged,